Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Miguel Seabra

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Anatomy

Disorders

Choroideremia

Living Beings

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequence

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
17
Hume, Alistair
12
Goldstein, Joseph
12
Brown, Michael
12
Ramalho, José
8
Tolmachova, Tanya
7
Wasmeier, Christina
7
Barral, Duarte
6
Huxley, Clare
5
Ali, Bassam
5
Armstrong, Scott
5
Mules, Emilie
5
Futter, Clare
5
Pereira-Leal, Jose
5
Tarafder, Abul
4
Raposo, Graça

Sign-in to see all Coauthors

Publications

TOP 3
Ramalho José S; Lopes Vanda S; Tarafder Abul K; Seabra Miguel C; Hume Alistair N
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.
Moosajee Mariya; Tulloch Merrin; Baron Rudi A; Gregory-Evans Cheryl Y; Pereira-Leal José B; Seabra Miguel C
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia.
Nightingale Thomas D; Pattni Krupa; Hume Alistair N; Seabra Miguel C; Cutler Daniel F
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Miguel Seabra (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Ramalho José S; Lopes Vanda S; Tarafder Abul K; Seabra Miguel C; Hume Alistair N
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.
Pigment cell & melanoma research 2009;22(4):461-73.
2009: Moosajee Mariya; Tulloch Merrin; Baron Rudi A; Gregory-Evans Cheryl Y; Pereira-Leal José B; Seabra Miguel C
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia.
Investigative ophthalmology & visual science 2009;50(6):3009-16.
2009: Nightingale Thomas D; Pattni Krupa; Hume Alistair N; Seabra Miguel C; Cutler Daniel F
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.
Blood 2009;113(20):5010-8.
2009: Baron Rudi A; Tavaré Richard; Figueiredo Ana C; Blazewska Katarzyna M; Kashemirov Boris A; McKenna Charles E; Ebetino Frank H; Taylor Adam; Rogers Michael J; Coxon Fraser P; Seabra Miguel C
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.
The Journal of biological chemistry 2009;284(11):6861-8.
2008: Wasmeier Christina; Hume Alistair N; Bolasco Giulia; Seabra Miguel C
Melanosomes at a glance.
Journal of cell science 2008;121(Pt 24):3995-9.
2008: Moosajee Mariya; Gregory-Evans Kevin; Ellis Charles D; Seabra Miguel C; Gregory-Evans Cheryl Y
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.
Human molecular genetics 2008;17(24):3987-4000.
2008: Baron Rudi A; Seabra Miguel C
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.
The Biochemical journal 2008;415(1):67-75.
2008: Figueiredo Ana C; Wasmeier Christina; Tarafder Abul K; Ramalho José S; Baron Rudi A; Seabra Miguel C
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.
The Journal of biological chemistry 2008;283(34):23209-16.
2007: Lopes Vanda S; Wasmeier Christina; Seabra Miguel C; Futter Clare E
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.
Molecular biology of the cell 2007;18(10):3914-27.
2007: Hume Alistair N; Ushakov Dmitry S; Tarafder Abul K; Ferenczi Michael A; Seabra Miguel C
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes.
Journal of cell science 2007;120(Pt 17):3111-22.
2007: Mizuno Kouichi; Tolmachova Tanya; Ushakov Dmitry S; Romao Maryse; Abrink Magnus; Ferenczi Michael A; Raposo Graça; Seabra Miguel C
Rab27b regulates mast cell granule dynamics and secretion.
Traffic (Copenhagen, Denmark) 2007;8(7):883-92.
2007: Lopes Vanda S; Ramalho José S; Owen Dylan M; Karl Mike O; Strauss Olaf; Futter Clare E; Seabra Miguel C
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.
Traffic (Copenhagen, Denmark) 2007;8(5):486-99.
2007: Tolmachova Tanya; Abrink Magnus; Futter Clare E; Authi Kalwant S; Seabra Miguel C
Rab27b regulates number and secretion of platelet dense granules.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5872-7.
2007: Jancic Carolina; Savina Ariel; Wasmeier Christina; Tolmachova Tanya; El-Benna Jamel; Dang Pham My-Chan; Pascolo Steve; Gougerot-Pocidalo Maire-Anne; Raposo Graça; Seabra Miguel C; Amigorena Sebastian
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.
Nature cell biology 2007;9(4):367-78.
2007: Leung Ka Fai; Baron Rudi; Ali Bassam R; Magee Anthony I; Seabra Miguel C
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.
The Journal of biological chemistry 2007;282(2):1487-97.
2006: Onfelt Björn; Nedvetzki Shlomo; Benninger Richard K P; Purbhoo Marco A; Sowinski Stefanie; Hume Alistair N; Seabra Miguel C; Neil Mark A A; French Paul M W; Davis Daniel M
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8476-83.
2006: Hume Alistair N; Tarafder Abul K; Ramalho José S; Sviderskaya Elena V; Seabra Miguel C
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.
Molecular biology of the cell 2006;17(11):4720-35.
2006: Wasmeier Christina; Romao Maryse; Plowright Lynn; Bennett Dorothy C; Raposo Graça; Seabra Miguel C
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.
The Journal of cell biology 2006;175(2):271-81.
2006: Savina Ariel; Jancic Carolina; Hugues Stephanie; Guermonprez Pierre; Vargas Pablo; Moura Ivan Cruz; Lennon-Duménil Ana-Maria; Seabra Miguel C; Raposo Graça; Amigorena Sebastian
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.
Cell 2006;126(1):205-18.
2006: Leung Ka Fai; Baron Rudi; Seabra Miguel C
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
Journal of lipid research 2006;47(3):467-75.
2006: Tolmachova Tanya; Anders Ross; Abrink Magnus; Bugeon Laurence; Dallman Margaret J; Futter Clare E; Ramalho José S; Tonagel Felix; Tanimoto Naoyuki; Seeliger Mathias W; Huxley Clare; Seabra Miguel C
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.
The Journal of clinical investigation 2006;116(2):386-94.
2005: Johnson Jennifer L; Ellis Beverly A; Noack Deborah; Seabra Miguel C; Catz Sergio D
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.
The Biochemical journal 2005;391(Pt 3):699-710.
2005: Chen Ying; Bellamy William P; Seabra Miguel C; Field Mark C; Ali Bassam R
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome.
Human molecular genetics 2005;14(17):2559-69.
2005: Coxon Fraser P; Ebetino Frank H; Mules Emilie H; Seabra Miguel C; McKenna Charles E; Rogers Michael J
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.
Bone 2005;37(3):349-58.
2005: Ali B R; Seabra M C
Targeting of Rab GTPases to cellular membranes.
Biochemical Society transactions 2005;33(Pt 4):652-6.
2005: Magee Tony; Seabra Miguel C
Fatty acylation and prenylation of proteins: what's hot in fat.
Current opinion in cell biology 2005;17(2):190-6.
2004: Ali Bassam R; Wasmeier Christina; Lamoreux Lynn; Strom Molly; Seabra Miguel C
Multiple regions contribute to membrane targeting of Rab GTPases.
Journal of cell science 2004;117(Pt 26):6401-12.
2004: Westbroek Wendy; Lambert Jo; De Schepper Sofie; Kleta Robert; Van Den Bossche Karolien; Seabra Miguel C; Huizing Marjan; Mommaas Mieke; Naeyaert Jean Marie
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(5):498-505.
2004: Seabra Miguel C; Wasmeier Christina
Controlling the location and activation of Rab GTPases.
Current opinion in cell biology 2004;16(4):451-7.
2004: Seabra Miguel C; Coudrier Evelyne
Rab GTPases and myosin motors in organelle motility.
Traffic (Copenhagen, Denmark) 2004;5(6):393-9.
2004: Futter Clare E; Ramalho José S; Jaissle Gesine B; Seeliger Mathias W; Seabra Miguel C
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells.
Molecular biology of the cell 2004;15(5):2264-75.
2004: Barral Duarte C; Seabra Miguel C
The melanosome as a model to study organelle motility in mammals.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(2):111-8.
2004: Ramalho J S; Gregory-Evans K; Huxley C; Seabra M C
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.
The British journal of ophthalmology 2004;88(3):428-32.
2004: Tolmachova Tanya; Anders Ross; Stinchcombe Jane; Bossi Giovanna; Griffiths Gillian M; Huxley Clare; Seabra Miguel C
A general role for Rab27a in secretory cells.
Molecular biology of the cell 2004;15(1):332-44.
2003: Magee Anthony I; Seabra Miguel C
Are prenyl groups on proteins sticky fingers or greasy handles?
The Biochemical journal 2003;376(Pt 2):e3-4.
2003: Tiwari Sanjay; Italiano Joseph E; Barral Duarte C; Mules Emilie H; Novak Edward K; Swank Richard T; Seabra Miguel C; Shivdasani Ramesh A
A role for Rab27b in NF-E2-dependent pathways of platelet formation.
Blood 2003;102(12):3970-9.
2003: Larijani Banafshé; Hume Alistair N; Tarafder Abul K; Seabra Miguel C
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.
The Journal of biological chemistry 2003;278(47):46798-804.
2003: Hannah Matthew J; Hume Alistair N; Arribas Monica; Williams Ross; Hewlett Lindsay J; Seabra Miguel C; Cutler Daniel F
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type.
Journal of cell science 2003;116(Pt 19):3939-48.
2003: Gomes Anita Q; Ali Bassam R; Ramalho Jose S; Godfrey Richard F; Barral Duarte C; Hume Alistair N; Seabra Miguel C
Membrane targeting of Rab GTPases is influenced by the prenylation motif.
Molecular biology of the cell 2003;14(5):1882-99.
2003: Anand Vibha; Barral Duarte C; Zeng Yong; Brunsmann Frank; Maguire Albert M; Seabra Miguel C; Bennett Jean
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus.
Vision research 2003;43(8):919-26.
2003: Pereira-Leal José B; Strom Molly; Godfrey Richard F; Seabra Miguel C
Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface.
Biochemical and biophysical research communications 2003;301(1):92-7.
2002: Ramalho José S; Anders Ross; Jaissle Gesine B; Seeliger Mathias W; Huxley Clare; Seabra Miguel C
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.
BMC cell biology 2002;3():26.
2002: Barral Duarte C; Ramalho José S; Anders Ross; Hume Alistair N; Knapton Holly J; Tolmachova Tanya; Collinson Lucy M; Goulding David; Authi Kalwant S; Seabra Miguel C
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome.
The Journal of clinical investigation 2002;110(2):247-57.
2002: Strom Molly; Hume Alistair N; Tarafder Abul K; Barkagianni Eleni; Seabra Miguel C
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.
The Journal of biological chemistry 2002;277(28):25423-30.
2002: Hume Alistair N; Collinson Lucy M; Hopkins Colin R; Strom Molly; Barral Duarte C; Bossi Giovanna; Griffiths Gillian M; Seabra Miguel C
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.
Traffic (Copenhagen, Denmark) 2002;3(3):193-202.
2002: Seabra Miguel C; Mules Emilie H; Hume Alistair N
Rab GTPases, intracellular traffic and disease.
Trends in molecular medicine 2002;8(1):23-30.
2002: Pereira-Leal José B; Gomes Anita Q; Seabra Miguel C
Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase.
Methods in molecular biology (Clifton, N.J.) 2002;189():157-65.
2001: Coxon F P; Helfrich M H; Larijani B; Muzylak M; Dunford J E; Marshall D; McKinnon A D; Nesbitt S A; Horton M A; Seabra M C; Ebetino F H; Rogers M J
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
The Journal of biological chemistry 2001;276(51):48213-22.
2001: Pereira-Leal J B; Seabra M C
Evolution of the Rab family of small GTP-binding proteins.
Journal of molecular biology 2001;313(4):889-901.
2001: Marks M S; Seabra M C
The melanosome: membrane dynamics in black and white.
Nature reviews. Molecular cell biology 2001;2(10):738-48.
2001: Pereira-Leal J B; Hume A N; Seabra M C
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.
FEBS letters 2001;498(2-3):197-200.
2001: Syed N; Smith J E; John S K; Seabra M C; Aguirre G D; Milam A H
Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia.
Ophthalmology 2001;108(4):711-20.
2001: Stinchcombe J C; Barral D C; Mules E H; Booth S; Hume A N; Machesky L M; Seabra M C; Griffiths G M
Rab27a is required for regulated secretion in cytotoxic T lymphocytes.
The Journal of cell biology 2001;152(4):825-34.
2001: Hume A N; Collinson L M; Rapak A; Gomes A Q; Hopkins C R; Seabra M C
Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
The Journal of cell biology 2001;152(4):795-808.
2001: Bergo M O; Leung G K; Ambroziak P; Otto J C; Casey P J; Gomes A Q; Seabra M C; Young S G
Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
The Journal of biological chemistry 2001;276(8):5841-5.
2001: Ramalho J S; Tolmachova T; Hume A N; McGuigan A; Gregory-Evans C Y; Huxley C; Seabra M C
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.
BMC genetics 2001;2():2.
2000: Pereira-Leal J B; Seabra M C
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.
Journal of molecular biology 2000;301(4):1077-87.
2000: Detter J C; Zhang Q; Mules E H; Novak E K; Mishra V S; Li W; McMurtrie E B; Tchernev V T; Wallace M R; Seabra M C; Swank R T; Kingsmore S F
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4144-9.
2000: Zhang H; Seabra M C; Deisenhofer J
Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure (London, England : 1993) 2000;8(3):241-51.
1999: Tolmachova T; Ramalho J S; Anant J S; Schultz R A; Huxley C M; Seabra M C
Cloning, mapping and characterization of the human RAB27A gene.
Gene 1999;239(1):109-16.
1998: Desnoyers L; Seabra M C
Single prenyl-binding site on protein prenyl transferases.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12266-70.
1998: Anant J S; Desnoyers L; Machius M; Demeler B; Hansen J C; Westover K D; Deisenhofer J; Seabra M C
Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.
Biochemistry 1998;37(36):12559-68.
1998: Seabra M C
Membrane association and targeting of prenylated Ras-like GTPases.
Cellular signalling 1998;10(3):167-72.
1998: Seabra M C; James G L
Prenylation assays for small GTPases.
Methods in molecular biology (Clifton, N.J.) 1998;84():251-60.
1996: van Bokhoven H; Rawson R B; Merkx G F; Cremers F P; Seabra M C
cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter.
Genomics 1996;38(2):133-40.
1996: Desnoyers L; Anant J S; Seabra M C
Geranylgeranylation of Rab proteins.
Biochemical Society transactions 1996;24(3):699-703.
1996: Seabra M C
Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab.
The Journal of biological chemistry 1996;271(24):14398-404.
1996: Wyne K L; Pathak K; Seabra M C; Hobbs H H
Expression of the VLDL receptor in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(3):407-15.
1996: Shen F; Seabra M C
Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein.
The Journal of biological chemistry 1996;271(7):3692-8.
1996: Mooser V; Seabra M C; Abedin M; Landschulz K T; Marcovina S; Hobbs H H
Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a).
The Journal of clinical investigation 1996;97(3):858-64.
1995: Seabra M C; Ho Y K; Anant J S
Deficient geranylgeranylation of Ram/Rab27 in choroideremia.
The Journal of biological chemistry 1995;270(41):24420-7.
1995: Armstrong S A; Brown M S; Goldstein J L; Seabra M C
Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins.
Methods in enzymology 1995;257():30-41.
1994: Smeland T E; Seabra M C; Goldstein J L; Brown M S
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10712-6.
1994: Cremers F P; Armstrong S A; Seabra M C; Brown M S; Goldstein J L
REP-2, a Rab escort protein encoded by the choroideremia-like gene.
The Journal of biological chemistry 1994;269(3):2111-7.
1993: Andres D A; Seabra M C; Brown M S; Armstrong S A; Smeland T E; Cremers F P; Goldstein J L
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Cell 1993;73(6):1091-9.
1993: Armstrong S A; Seabra M C; Südhof T C; Goldstein J L; Brown M S
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.
The Journal of biological chemistry 1993;268(16):12221-9.
1993: Seabra M C; Brown M S; Goldstein J L
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.
Science (New York, N.Y.) 1993;259(5093):377-81.
1992: Seabra M C; Brown M S; Slaughter C A; Südhof T C; Goldstein J L
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Cell 1992;70(6):1049-57.
1992: Seabra M C; Goldstein J L; Südhof T C; Brown M S
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.
The Journal of biological chemistry 1992;267(20):14497-503.
1992: Reiss Y; Seabra M C; Brown M S; Goldstein J L
p21ras farnesyltransferase: purification and properties of the enzyme.
Biochemical Society transactions 1992;20(2):487-8.
1991: Reiss Y; Seabra M C; Armstrong S A; Slaughter C A; Goldstein J L; Brown M S
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.
The Journal of biological chemistry 1991;266(16):10672-7.
1991: Seabra M C; Reiss Y; Casey P J; Brown M S; Goldstein J L
Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.
Cell 1991;65(3):429-34.
1990: Reiss Y; Goldstein J L; Seabra M C; Casey P J; Brown M S
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
Cell 1990;62(1):81-8.

Sign-in to see more