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Said Sebti

Research Profile

Chemicals & Drugs

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TOP 3
Deniz A Ucar; Maria Zajac-Kaye; Jianliang Zhang; Di-Hua He; Elena Kurenova; Nicholas J Lawrence; Andrew T Magis; Said M Sebti; Steven N Hochwald
Inhibiting the Interaction of cMET and IGF-1R with FAK Effectively Reduces Growth of Pancreatic Cancer Cells in vitro and in vivo.
Kazim Husain; Noreen Luetteke; Marta Perez; Said M Sebti; Guo Zhang Lee; Barbara A Centeno; Dung-Tsa Chen; William J Fulp; Sunil R Hingorani; Mokenge P Malafa
Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol.
Pamela J Hodul; Kazim Husain; Dung-Tsa Chen; Jiandong Chen; Domenico Coppola; Yanbin Dong; Rony Francois; Jose M Pimiento; Warren J Pledger; Said M Sebti; Anying Zhang; Mokenge P Malafa
Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.

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2013: Deniz A Ucar; Maria Zajac-Kaye; Jianliang Zhang; Di-Hua He; Elena Kurenova; Nicholas J Lawrence; Andrew T Magis; Said M Sebti; Steven N Hochwald
Inhibiting the Interaction of cMET and IGF-1R with FAK Effectively Reduces Growth of Pancreatic Cancer Cells in vitro and in vivo.
Anti-cancer agents in medicinal chemistry 2013;13(4):595-602.
2013: Kazim Husain; Noreen Luetteke; Marta Perez; Said M Sebti; Guo Zhang Lee; Barbara A Centeno; Dung-Tsa Chen; William J Fulp; Sunil R Hingorani; Mokenge P Malafa
Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol.
Carcinogenesis 2013;34(4):858-63.
2013: Pamela J Hodul; Kazim Husain; Dung-Tsa Chen; Jiandong Chen; Domenico Coppola; Yanbin Dong; Rony Francois; Jose M Pimiento; Warren J Pledger; Said M Sebti; Anying Zhang; Mokenge P Malafa
Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.
PloS one 2013;8(2):e52526.
2012: Deniz A Ucar; Maria Zajac-Kaye; William G Cance; Audrey Cox; Timothy J Garrett; Elena Kurenova; Nicholas Lawrence; Nicole A Massoll; Carl Nyberg; David A Ostrov; Said M Sebti; Steven N Hochwald
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
Cell cycle (Georgetown, Tex.) 2012;11(17):3250-9.
2012: Gisela Caceres; Justine Clark; Nicholas J Lawrence; Kathy L McGraw; Robert W Robey; Said M Sebti; Lubomir Sokol; Michael Wiese; Alan F List
HG-829 is a potent noncompetitive inhibitor of the ATP-binding cassette multidrug resistance transporter ABCB1.
Cancer research 2012;72(16):4204-13.
2012: Hla Win-Piazza; Liwei Chen; Harshani R Lawrence; Nicholas J Lawrence; Daniele Pernazza; Valentina E Schneeberger; Said M Sebti; Jie Wu
Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2.
Cancer letters 2012;320(1):81-5.
2012: Mathew P Martin; Sevil Ozcan; Roberta Pireddu; Riazul Alam; Harshani R Lawrence; Nicholas J Lawrence; Yunting Luo; Said M Sebti; Jin-Yi Zhu; Ernst Schönbrunn
A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.
ACS chemical biology 2012;7(4):698-706.
2012: Rongshi Li; Yan Liu; Mathew P Martin; Ronil A Patel; Roberta Pireddu; Ernst Schonbrunn; Wayne C Guida; Eric B Haura; Nicholas J Lawrence; Jiannong Li; Nan Sun; Shen-Shu Sung; Binglin Wang; Jin-Yi Zhu; Said M Sebti
Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.
Journal of medicinal chemistry 2012;55(5):2474-8.
2012: Yiyu Ge; Wayne C Guida; Sanjula Jain; Aslamuzzaman Kazi; Wesley Brooks; Kenyon G Daniel; Yunting Luo; Frank Marsilio; Said M Sebti; Harshani R Lawrence
Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.
Journal of medicinal chemistry 2012;55(5):1978-98.
2012: Jackie L Johnson; Nicholas J Lawrence; Daniele Pernazza; Smitha Pillai; Said M Sebti; Srikumar Chellappan
Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.
Cancer research 2012;72(2):516-26.
2012: Thomas F Gajewski; Frank Haluska; Jeffrey Johnson; Gerald Linette; Donna Niedzwiecki; April K S Salama; Said M Sebti; Michelle A Blaskovich; Cynthia Bucher
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
Journal of translational medicine 2012;10():246.
2011: Bert O Neil; Said M Sebti; Jonathan R Strosberg; Tanios Bekaii-Saab; Laura W Goff; John Sae Wook Kauh; Aslamuzzaman Kazi; Maria Learoyd; Ruey-Min Lee; Richard M Lush; Dominic T Moore; Daniel M Sullivan
Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(17):2350-6.
2011: Yaogang Hu; Xiaolong Li; Said M Sebti; Jiandong Chen; Jianfeng Cai
Design and synthesis of AApeptides: a new class of peptide mimics.
Bioorganic & medicinal chemistry letters 2011;21(5):1469-71.
2011: Latanya M Scott; Liwei Chen; Kenyon G Daniel; Wesley H Brooks; Wayne C Guida; Harshani R Lawrence; Said M Sebti; Nicholas J Lawrence; Jie Wu
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
Bioorganic & medicinal chemistry letters 2011;21(2):730-3.
2010: Stephen Fletcher; Erin Pusateri Keaney; Christopher G Cummings; Michelle A Blaskovich; Michael A Hast; Matthew Glenn; Sung-Youn Chang; Cynthia J Bucher; Ryan J Floyd; William P Katt; Michael H Gelb; Wesley C Van Voorhis; Lorena S Beese; Said M Sebti; Andrew D Hamilton
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Journal of medicinal chemistry 2010;53(19):6867-88.
2010: Liwei Chen; Daniele Pernazza; Latanya M Scott; Harshani R Lawrence; Yuan Ren; Yunting Luo; Xin Wu; Shen-Shu Sung; Wayne C Guida; Said M Sebti; Nicholas J Lawrence; Jie Wu
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.
Biochemical pharmacology 2010;80(6):801-10.
2010: Donghwa Kim; Mei Sun; Lili He; Qing-Hua Zhou; Jun Chen; Xiameng SUN; Gerold Bepler; Said M Sebti; Jin Q Cheng
A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
The Journal of biological chemistry 2010;285(11):8383-94.
2010: Kiran N Mahajan; Domenico Coppola; Sridevi Challa; Bin Fang; Y Ann Chen; Weiwei Zhu; Alexis S Lopez; John Koomen; Robert W Engelman; Charlene Rivera; Rebecca S Muraoka-Cook; Jin Q Cheng; Ernst Schönbrunn; Said M Sebti; H Shelton Earp; Nupam P Mahajan
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
PloS one 2010;5(3):e9646.
2009: David S Hong; Said M Sebti; Robert A Newman; Michelle A Blaskovich; Lei Ye; Robert F Gagel; Stacy Moulder; Jennifer J Wheler; Aung Naing; Nizar M Tannir; Chaan S Ng; Steven I Sherman; Adel K El-Naggar; Rabia Khan; Jonathan Trent; John J Wright; Razelle Kurzrock
Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):7061-8.
2009: Joseph A Sparano; Stacy Moulder; Aslamuzzaman Kazi; Domenico Coppola; Abdissa Negassa; Linda Vahdat; Tianhong Li; Christine Pellegrino; Susan Fineberg; Pam Munster; Mokenge Malafa; David Lee; Shira Hoschander; Una Hopkins; Dawn Hershman; John J Wright; Celina G Kleer; Sofia D Merajver; Said M Sebti
Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2942-8.
2009: Aslamuzzaman Kazi; Adam Carie; Michelle A Blaskovich; Cynthia Bucher; Van Thai; Stacy Moulder; Hairuo Peng; Dora Carrico; Erin Pusateri; Warren Pledger; Norbert Berndt; Andrew Hamilton; Said M Sebti
Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.
Molecular and cellular biology 2009;29(8):2254-63.
2009: Michael A Hast; Stephen Fletcher; Christopher G Cummings; Erin E Pusateri; Michelle A Blaskovich; Kasey Rivas; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton; Lorena S Beese
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Chemistry & biology 2009;16(2):181-92.
2009: Katherine J Kayser-Bricker; Matthew P Glenn; Sang Hoon Lee; Said M Sebti; Jin Q Cheng; Andrew D Hamilton
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.
Bioorganic & medicinal chemistry 2009;17(4):1764-71.
2008: Stephen Fletcher; Christopher G Cummings; Kasey Rivas; William P Katt; Carrie Hornéy; Frederick S Buckner; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Journal of medicinal chemistry 2008;51(17):5176-97.
2008: Sigrun Gustafsdottir; Stefan Wennström; Simon Fredriksson; Edith Schallmeiner; Andrew D Hamilton; Said M Sebti; Ulf Landegren
Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors.
Clinical chemistry 2008;54(7):1218-25.
2008: Rebecca Kinkade; Piyali Dasgupta; Adam Carie; Daniele Pernazza; Melanie A Carless; Smitha Pillai; Nicholas Lawrence; Said M Sebti; Srikumar Chellappan
A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.
Cancer research 2008;68(10):3810-8.
2008: Razelle Kurzrock; Hagop M Kantarjian; Michelle A Blascovich; Cindy Bucher; Srdan Verstovsek; John J Wright; Susan R Pilat; Jorge E Cortes; Elihu H Estey; Francis Giles; Miloslav Beran; Said M Sebti
Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):509-14.
2007: Khandaker Siddiquee; Patrick T Gunning; Matthew Glenn; William P Katt; Shumin Zhang; Christopher Schrock; Christopher Schroeck; Said M Sebti; Richard Jove; Andrew D Hamilton; James Turkson
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.
ACS chemical biology 2007;2(12):787-98.
2007: Samuel C Falsetti; De-an Wang; Hairuo Peng; Dora Carrico; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Said M Sebti
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Molecular and cellular biology 2007;27(22):8003-14.
2007: Adam Carie; Said M Sebti
A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway.
Oncogene 2007;26(26):3777-88.
2007: Khandaker Siddiquee; Shumin Zhang; Wayne C Guida; Michelle A Blaskovich; Benjamin Greedy; Harshani R Lawrence; M L Richard Yip; Richard Jove; Mark M McLaughlin; Nicholas J Lawrence; Said M Sebti; James Turkson
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7391-6.
2007: Francesco Epifano; Massimo Curini; Salvatore Genovese; Michelle A Blaskovich; Andrew Hamilton; Said M Sebti
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
Bioorganic & medicinal chemistry letters 2007;17(9):2639-42.
2007: Patrick T Gunning; William P Katt; Matthew Glenn; Khandaker Siddiquee; Khandaker Siddique; Joon S Kim; Richard Jove; Said M Sebti; James Turkson; Andrew D Hamilton
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.
Bioorganic & medicinal chemistry letters 2007;17(7):1875-8.
2007: Katherine J Kayser; Matthew Glenn; Said M Sebti; Jin Q Cheng; Andrew D Hamilton
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
Bioorganic & medicinal chemistry letters 2007;17(7):2068-73.
2007: Frederic Delarue; Jalila Adnane; Bharat Joshi; Michelle A Blaskovich; De-an Wang; J Hawker; Francisco Bizouarn; Junko Ohkanda; K Zhu; Andrew D Hamilton; Srikumar Chellappan; Said M Sebti
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene 2007;26(5):633-40.
2006: Baoli Hu; Daniele M Gilkes; Bilal Farooqi; Said M Sebti; Jiandong Chen
MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.
The Journal of biological chemistry 2006;281(44):33030-5.
2006: Matthew Glenn; Sung-Youn Chang; Carrie Hornéy; Kasey Rivas; Kohei Yokoyama; Erin E Pusateri; Stephen Fletcher; Christopher G Cummings; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
2006: Dongjiang Tang; Ho-Jin Park; Serban P Georgescu; Said M Sebti; Andrew D Hamilton; Jonas B Galper
Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
Life sciences 2006;79(15):1484-92.
2006: Liwei Chen; Shen-Shu Sung; M L Richard Yip; Harshani R Lawrence; Yuan Ren; Wayne C Guida; Said M Sebti; Nicholas J Lawrence; Jie Wu
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Molecular pharmacology 2006;70(2):562-70.
2006: Joseph A Sparano; Stacy Moulder; Aslamuzzaman Kazi; Linda Vahdat; Tianhong Li; Christine Pellegrino; Pamela N Munster; Mokenge Malafa; David Lee; Shira Hoschander; Una Hopkins; Dawn Hershman; John J Wright; Said M Sebti
Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(19):3013-8.
2006: Huchen Zhou; De-an Wang; Laura Baldini; Eileen Ennis; Rishi Jain; Adam Carie; Said M Sebti; Andrew D Hamilton
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.
Organic & biomolecular chemistry 2006;4(12):2376-86.
2006: Hairuo Peng; Dora Carrico; Van Thai; Michelle A Blaskovich; Cynthia J Bucher; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Organic & biomolecular chemistry 2006;4(9):1768-84.
2006: Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2006: Sreenivasa Donapaty; Somaja Louis; Elizabeth Horvath; Jiang Kun; Said M Sebti; Mokenge P Malafa
RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
Molecular cancer therapeutics 2006;5(2):309-16.
2005: Wayne C Guida; Andrew D Hamilton; Justin W Crotty; Said M Sebti
Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.
Journal of computer-aided molecular design 2005;19(12):871-85.
2005: Yoshinori Takahashi; Mariusz Karbowski; Hirohito Yamaguchi; Aslamuzzaman Kazi; Jie Wu; Said M Sebti; Richard J Youle; Hong-Gang Wang
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.
Molecular and cellular biology 2005;25(21):9369-82.
2005: Yulia Nefedova; Srinivas Nagaraj; Amsler Rosenbauer; Carlos Muro-Cacho; Said M Sebti; Dmitry I Gabrilovich
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.
Cancer research 2005;65(20):9525-35.
2005: Yulia Nefedova; Pingyan Cheng; Daniele Gilkes; Michelle A Blaskovich; Amer A Beg; Said M Sebti; Dmitry I Gabrilovich
Activation of dendritic cells via inhibition of Jak2/STAT3 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4338-46.
2005: Timothy F Cloughesy; John Kuhn; H Ian Robins; Lauren E Abrey; Patrick Y Wen; Karen Fink; Frank S Lieberman; Minesh Mehta; Susan Chang; Alfred Yung; Lisa De Angelis; David Schiff; Larry Junck; Morris Groves; Steve Paquette; John Wright; Kathleen R Lamborn; Said M Sebti; Michael Prados
Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6647-56.
2005: Matthew Glenn; Sung-Youn Chang; Oliver Hucke; Christophe Verlinde; Kasey Rivas; Carrie Hornéy; Kohei Yokoyama; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
2005: Hang Yin; Gui-in Lee; Kristine A Sedey; Olaf Kutzki; Hyung Soon Park; Brendan P Orner; Justin T Ernst; Hong-Gang Wang; Said M Sebti; Andrew D Hamilton
Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
Journal of the American Chemical Society 2005;127(29):10191-6.
2005: Jiazhi Sun; De-an Wang; Rishi Jain; Adam Carie; Steve Paquette; Eileen Ennis; Michelle A Blaskovich; Laura Baldini; Domenico Coppola; Andrew D Hamilton; Said M Sebti
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
Oncogene 2005;24(29):4701-9.
2005: Kuichun Zhu; Elvira Gerbino; Darrin M Beaupre; Paul A Mackley; Carlos Muro-Cacho; Craig Beam; Andrew D Hamilton; Mathias G Lichtenheld; William G Kerr; William Dalton; Melissa Alsina; Said M Sebti
Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.
Blood 2005;105(12):4759-66.
2005: De-An Wang; Said M Sebti
Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.
The Journal of biological chemistry 2005;280(19):19243-9.
2005: Jiazhi Sun; Michelle A Blaskovich; Richard Jove; Sandra K Livingston; Domenico Coppola; Said M Sebti
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.
Oncogene 2005;24(20):3236-45.
2005: Hang Yin; Gui-in Lee; Hyung Soon Park; Gregory A Payne; Johanna Rodriguez; Said M Sebti; Andrew D Hamilton
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Angewandte Chemie (International ed. in English) 2005;44(18):2704-7.
2005: Hang Yin; Gui-in Lee; Kristine A Sedey; Johanna Rodriguez; Hong-Gang Wang; Said M Sebti; Andrew D Hamilton
Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction.
Journal of the American Chemical Society 2005;127(15):5463-8.
2005: Said M Sebti
Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy.
Cancer cell 2005;7(4):297-300.
2005: Julien Mazières; Vanessa Tillement; Cuider Allal; Carine Clanet; Lisbeth Bobin; Zhi Chen; Said M Sebti; Gilles FAVRE; Anne Pradines
Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells.
Experimental cell research 2005;304(2):354-64.
2005: Dora Carrico; Michelle A Blaskovich; Cynthia J Bucher; Said M Sebti; Andrew D Hamilton
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry 2005;13(3):677-88.
2005: Je-Tae Woo; Hiroshi Nakagawa; Annette M Krecic; Kazuo Nagai; Andrew D Hamilton; Said M Sebti; Paula H Stern
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha).
Biochemical pharmacology 2005;69(1):87-95.
2004: Dora Carrico; Junko Ohkanda; Howard Kendrick; Kohei Yokoyama; Michelle A Blaskovich; Cynthia J Bucher; Frederick S Buckner; Wesley C Van Voorhis; Debopam Chakrabarti; Simon L Croft; Michael H Gelb; Said M Sebti; Andrew D Hamilton
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Piyali Dasgupta; Jiazhi Sun; Sheng Wang; Gina Fusaro; Vicki Betts; Jaya Padmanabhan; Said M Sebti; Srikumar Chellappan
Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.
Molecular and cellular biology 2004;24(21):9527-41.
2004: Lin Yang; Han C Dan; Mei Sun; Qiyuan Liu; Xiameng SUN; Richard I Feldman; Andrew D Hamilton; Mark A Polokoff; Santo V Nicosia; Meenhard Herlyn; Said M Sebti; Jin Q Cheng
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
Cancer research 2004;64(13):4394-9.
2004: Jiazhi Sun; Michelle A Blaskovich; Rishi Jain; Frederic Delarue; Daniel Paris; Steven Brem; Marguerite Wotoczek-Obadia; Qing Lin; Domenico Coppola; Kihang Choi; Michael Mullan; Andrew D Hamilton; Said M Sebti
Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Cancer research 2004;64(10):3586-92.
2004: Melissa Alsina; Rafael Fonseca; Edward F Wilson; A Nelida Belle; Elvira Gerbino; Tammy Price-Troska; Rose M Overton; Gregory J Ahmann; Laura M Bruzek; Alex A. Adjei; Scott H Kaufmann; John J Wright; Daniel Sullivan; Benjamin Djulbegovic; Alan B Cantor; Philip R Greipp; William S Dalton; Said M Sebti
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma.
Blood 2004;103(9):3271-7.
2004: Kun Jiang; Frederic L Delarue; Said M Sebti
EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
Oncogene 2004;23(5):1136-45.
2004: Said M Sebti; Alex A. Adjei
Farnesyltransferase inhibitors.
Seminars in oncology 2004;31(1 Suppl 1):28-39.
2004: Han C Dan; Kun Jiang; Domenico Coppola; Andrew Hamilton; Santo V Nicosia; Said M Sebti; Jin Q Cheng
Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.
Oncogene 2004;23(3):706-15.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2004: Daniel Paris; Kirk Townsend; Amita Quadros; James Humphrey; Jiazhi Sun; Steven Brem; Marguerite Wotoczek-Obadia; Anthony DelleDonne; Nikunj Patel; Demian Obregon; Robert Crescentini; Laila Abdullah; Domenico Coppola; Amyn M Rojiani; Fiona Crawford; Said M Sebti; Michael Mullan
Inhibition of angiogenesis by Abeta peptides.
Angiogenesis 2004;7(1):75-85.
2003: Jiazhi Sun; Junko Ohkanda; Domenico Coppola; Hang Yin; Mohit Kothare; Brian Busciglio; Andrew D Hamilton; Said M Sebti
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Cancer research 2003;63(24):8922-9.
2003: Razelle Kurzrock; Hagop M Kantarjian; Jorge E Cortes; Neil Singhania; Deborah A Thomas; Edward F Wilson; John J Wright; Emil J Freireich; Moshe Talpaz; Said M Sebti
Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting.
Blood 2003;102(13):4527-34.
2003: Kuichun Zhu; Andrew D Hamilton; Said M Sebti
Farnesyltransferase inhibitors as anticancer agents: current status.
Current opinion in investigational drugs (London, England : 2000) 2003;4(12):1428-35.
2003: Said M Sebti; Channing J Der
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors.
Nature reviews. Cancer 2003;3(12):945-51.
2003: Maria Forsberg; Robert Blomgran; Maria Lerm; Eva Särndahl; Said M Sebti; Andrew Hamilton; Olle Stendahl; Limin Zheng
Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt.
Journal of leukocyte biology 2003;74(4):620-9.
2003: Zhongqiu Zhang; Yian Wang; Laura E Lantry; Elizabeth Kastens; Gongjie Liu; Andrew D Hamilton; Said M Sebti; Ronald A Lubet; Ming You
Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf.
Oncogene 2003;22(40):6257-65.
2003: Bruno B Bordier; Junko Ohkanda; Ping Liu; So-Young Lee; F H Salazar; Patricia L Marion; Kazuo Ohashi; Leonard Meuse; Mark A Kay; John L Casey; Said M Sebti; Andrew D Hamilton; Jeffrey S Glenn
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
The Journal of clinical investigation 2003;112(3):407-14.
2003: Michelle A Blaskovich; Jiazhi Sun; Alan Cantor; James Turkson; Richard Jove; Said M Sebti
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
Cancer research 2003;63(6):1270-9.
2003: Sophie F Doisneau-Sixou; Philippe Cestac; Sarah Chouini; Jason S Carroll; Andrew D Hamilton; Said M Sebti; Marc Poirot; Patrick Balaguer; Jean-Charles Faye; Robert L Sutherland; Gilles FAVRE
Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.
Endocrinology 2003;144(3):989-98.
2003: Said M Sebti
Blocked pathways: FTIs shut down oncogene signals.
The oncologist 2003;8 Suppl 3():30-8.
2003: Junko Ohkanda; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Progress in cell cycle research 2003;5():211-7.
2003: Antonio Mazzocca; Sabrina Giusti; Andrew D Hamilton; Said M Sebti; Pietro Pantaleo; Vinicio Carloni
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
Molecular pharmacology 2003;63(1):159-66.
2002: Rosalind J Jackson; Jalila Adnane; Domenico Coppola; Alan Cantor; Said M Sebti; Warren Pledger
Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models.
Oncogene 2002;21(55):8486-97.
2002: Cuider Allal; Anne Pradines; Andrew D Hamilton; Said M Sebti; Gilles FAVRE
Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298.
Cell cycle (Georgetown, Tex.) 2002;1(6):430-7.
2002: Jalila Adnane; Carlos Muro-Cacho; Linda Mathews; Said M Sebti; Teresita Muñoz-Antonia
Suppression of rho B expression in invasive carcinoma from head and neck cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2225-32.
2002: N C Crespo; Frederic Delarue; Junko Ohkanda; Dora Carrico; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Cell death and differentiation 2002;9(7):702-9.
2002: Xianwu Li; Li Liu; Joan C Tupper; Douglas D Bannerman; Robert K Winn; Said M Sebti; Andrew D Hamilton; John M Harlan
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
The Journal of biological chemistry 2002;277(18):15309-16.
2002: Claire E Walters; Gareth Pryce; Deborah J R Hankey; Said M Sebti; Andrew D Hamilton; David Baker; John Greenwood; Peter Adamson
Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4087-94.
2002: Jalila Adnane; Edward Seijo; Zhi Chen; Francisco Bizouarn; Martha Leal; Said M Sebti; Teresita Muñoz-Antonia
RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.
The Journal of biological chemistry 2002;277(10):8500-7.
2002: Junko Ohkanda; David B Knowles; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Current topics in medicinal chemistry 2002;2(3):303-23.
2002: Junko Ohkanda; Jeffrey W Lockman; Mohit A Kothare; Yimin Qian; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
2001: Umberto Kucich; J C Rosenbloom; David J Herrick; William Abrams; Andrew D Hamilton; Said M Sebti; Joel Rosenbloom
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts.
Archives of biochemistry and biophysics 2001;395(1):103-12.
2001: Frederic Delarue; Bradley Taylor; Said M Sebti
Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells.
Oncogene 2001;20(45):6531-7.
2001: Jonathan D Finder; J L Petrus; Andrew Hamilton; Raphael T Villavicencio; Bruce R Pitt; Said M Sebti
Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L816-23.
2001: N C Crespo; Junko Ohkanda; T J Yen; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
The Journal of biological chemistry 2001;276(19):16161-7.
2001: Junko Ohkanda; Jeffrey W Lockman; Kohei Yokoyama; Michael H Gelb; Simon L Croft; H Kendrick; M I Harrell; JE Feagin; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
2001: Jiazhi Sun; S Nam; C S Lee; B Li; Domenico Coppola; Andrew D Hamilton; Qingping Dou; Said M Sebti
CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice.
Cancer research 2001;61(4):1280-4.
2000: Said M Sebti; Andrew D Hamilton
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.
Expert opinion on investigational drugs 2000;9(12):2767-82.
2000: Jalila Adnane; Francisco Bizouarn; Zhi Chen; Junko Ohkanda; Andrew D Hamilton; T Munoz-Antonia; Said M Sebti
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Oncogene 2000;19(48):5525-33.
2000: Jalila Adnane; Rosalind J Jackson; Santo V Nicosia; Alan B Cantor; Warren Pledger; Said M Sebti
Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model.
Oncogene 2000;19(47):5338-47.
2000: Cuider Allal; Gilles FAVRE; Bettina Couderc; S Salicio; S Sixou; Andrew D Hamilton; Said M Sebti; Isabelle Lajoie-Mazenc; Anne Pradines
RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.
The Journal of biological chemistry 2000;275(40):31001-8.
2000: Michelle A Blaskovich; Q Lin; Frederic Delarue; Jiazhi Sun; H S Park; Domenico Coppola; Andrew D Hamilton; Said M Sebti
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
Nature biotechnology 2000;18(10):1065-70.
2000: Elizabeth Cohen-Jonathan; Ruth J Muschel; W Gillies McKenna; Sydney Evans; george cerniglia; Rosemarie Mick; D Kusewitt; Said M Sebti; Andrew D Hamilton; Allen Oliff; Nancy E Kohl; Jackson B Gibbs; Eric J Bernhard
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
Radiation research 2000;154(2):125-32.
2000: Joel Rosenbloom; Biagio Saitta; Svetlana Gaidarova; Nora Sandorfi; J C Rosenbloom; William Abrams; Andrew D Hamilton; Said M Sebti; Umberto Kucich; Sergio A Jimenez
Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I.
Arthritis and rheumatism 2000;43(7):1624-32.
2000: Zhi Chen; Jiazhi Sun; Anne Pradines; Gilles FAVRE; Jalila Adnane; Said M Sebti
Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice.
The Journal of biological chemistry 2000;275(24):17974-8.
2000: Umberto Kucich; J C Rosenbloom; G Shen; William Abrams; Andrew D Hamilton; Said M Sebti; Joel Rosenbloom
TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2.
Archives of biochemistry and biophysics 2000;374(2):313-24.
2000: A Boota; B Johnson; K L Lee; Michelle A Blaskovich; Shang-Xi Liu; Valerian E Kagan; Andrew Hamilton; Bruce R Pitt; Said M Sebti; P Davies
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L329-34.
2000: Said M Sebti; Andrew D Hamilton
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.
Methods in enzymology 2000;325():381-8.
2000: Vinicio Carloni; Massimo Pinzani; Sabrina Giusti; Roberto Giulio Romanelli; Maurizio Parola; Giorgio Bellomo; Paola Failli; A D Hamilton; Said M Sebti; Giacomo Laffi; Paolo Gentilini
Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.
Hepatology (Baltimore, Md.) 2000;31(1):131-40.
2000: Laura E Lantry; Zhongqiu Zhang; R Yao; Keith Crist; Yian Wang; J Ohkanda; A D Hamilton; Said M Sebti; Ronald A Lubet; Ming You
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis 2000;21(1):113-6.
1999: Yimin Qian; J J Marugan; R D Fossum; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):3011-24.
1999: J Sun; Michelle A Blaskovich; D Knowles; Y Qian; Junko Ohkanda; Ratna D Bailey; Andrew D Hamilton; Said M Sebti
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer research 1999;59(19):4919-26.
1999: Elizabeth Cohen-Jonathan; Christine Toulas; Isabelle Ader; S Monteil; Cuider Allal; Jacques Bonnet; Andrew D Hamilton; Said M Sebti; Nicolas Daly-Schveitzer; Gilles FAVRE
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS.
Radiation research 1999;152(4):404-11.
1999: A Vasudevan; Yimin Qian; Andreas Vogt; Michelle A Blaskovich; Junko Ohkanda; Said M Sebti; Andrew D Hamilton
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
1999: Jiazhi Sun; Y Qian; Zhi Chen; J Marfurt; Andrew D Hamilton; Said M Sebti
The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.
The Journal of biological chemistry 1999;274(11):6930-4.
1998: Jalila Adnane; Francisco Bizouarn; Y Qian; Andrew D Hamilton; Said M Sebti
p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
Molecular and cellular biology 1998;18(12):6962-70.
1998: Umberto Kucich; J C Rosenbloom; G Shen; William Abrams; Michelle A Blaskovich; Andrew D Hamilton; Junko Ohkanda; Said M Sebti; Joel Rosenbloom
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochemical and biophysical research communications 1998;252(1):111-6.
1998: W W Stark; Michelle A Blaskovich; B A Johnson; Yimin Qian; A Vasudevan; Bruce R Pitt; Andrew D Hamilton; Said M Sebti; P Davies
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The American journal of physiology 1998;275(1 Pt 1):L55-63.
1998: Eric J Bernhard; W Gillies McKenna; Andrew D Hamilton; Said M Sebti; Y Qian; J M Wu; Ruth J Muschel
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Cancer research 1998;58(8):1754-61.
1998: Yimin Qian; Andreas Vogt; A Vasudevan; Said M Sebti; Andrew D Hamilton
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.
Bioorganic & medicinal chemistry 1998;6(3):293-9.
1997: Said M Sebti; Andrew D Hamilton
Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.
Expert opinion on investigational drugs 1997;6(11):1711-4.
1997: Andreas Vogt; J Sun; Yimin Qian; Andrew D Hamilton; Said M Sebti
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
The Journal of biological chemistry 1997;272(43):27224-9.
1997: Edwina C Lerner; TT Zhang; D B Knowles; Yimin Qian; Andrew D Hamilton; Said M Sebti
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Oncogene 1997;15(11):1283-8.
1997: Jonathan D Finder; J L Litz; Michelle A Blaskovich; Terence F Mcguire; Yimin Qian; Andrew D Hamilton; P Davies; Said M Sebti
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(21):13484-8.
1997: K Miquel; Anne Pradines; J Sun; Y Qian; Andrew D Hamilton; Said M Sebti; Gilles FAVRE
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Cancer research 1997;57(10):1846-50.
1997: Terence F Mcguire; Said M Sebti
Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity.
Oncogene 1997;14(3):305-12.
1997: Said M Sebti; Andrew D Hamilton
Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.
Pharmacology & therapeutics 1997;74(1):103-14.
1997: Yimin Qian; Said M Sebti; Andrew D Hamilton
Farnesyltransferase as a target for anticancer drug design.
Biopolymers 1997;43(1):25-41.
1996: Andreas Vogt; Yimin Qian; Terence F Mcguire; Andrew D Hamilton; Said M Sebti
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Oncogene 1996;13(9):1991-9.
1996: Terence F Mcguire; Yimin Qian; Andreas Vogt; Andrew D Hamilton; Said M Sebti
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
The Journal of biological chemistry 1996;271(44):27402-7.
1996: Z Pei; Said M Sebti
Cys102 and His398 are required for bleomycin-inactivating activity but not for hexamer formation of yeast bleomycin hydrolase.
Biochemistry 1996;35(33):10751-6.
1996: Said M Sebti; Andrew D Hamilton
Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs.
Biochemical Society transactions 1996;24(3):692-9.
1996: Eric J Bernhard; Gary D Kao; Adrienne D Cox; Said M Sebti; Andrew D Hamilton; Ruth J Muschel; W Gillies McKenna
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
Cancer research 1996;56(8):1727-30.
1996: X Q Xu; Terence F Mcguire; Michelle A Blaskovich; Said M Sebti; Guillermo Romero
Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts.
Archives of biochemistry and biophysics 1996;326(2):233-7.
1996: Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Journal of medicinal chemistry 1996;39(1):217-23.
1996: John Lazo; Said M Sebti; J H Schellens
Bleomycin.
Cancer chemotherapy and biological response modifiers 1996;16():39-47.
1995: R C Kauffmann; Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton; Richard W Carthew
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10919-23.
1995: E C Lerner; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andreas Vogt; J Sun; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Said M Sebti
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
1995: E C Lerner; Yimin Qian; Andrew D Hamilton; Said M Sebti
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
The Journal of biological chemistry 1995;270(45):26770-3.
1995: J Sun; Yimin Qian; Andrew D Hamilton; Said M Sebti
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
Cancer research 1995;55(19):4243-7.
1995: Z Pei; T P Calmels; C E Creutz; Said M Sebti
Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells.
Molecular pharmacology 1995;48(4):676-81.
1995: Andreas Vogt; J Sun; Yimin Qian; E Tan-Chiu; Andrew D Hamilton; Said M Sebti
Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.
Biochemistry 1995;34(38):12398-403.
1995: Andreas Vogt; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andrew D Hamilton; Said M Sebti
A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
The Journal of biological chemistry 1995;270(2):660-4.
1994: Terence F Mcguire; X Q Xu; Seth J Corey; Guillermo G Romero; Said M Sebti
Lovastatin disrupts early events in insulin signaling: a potential mechanism of lovastatin's anti-mitogenic activity.
Biochemical and biophysical research communications 1994;204(1):399-406.
1994: WEILI WENG; I J Reynolds; J P Jani; Michelle A Blaskovich; Said M Sebti; P Davies; Bruce R Pitt
Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture.
Microcirculation (New York, N.Y. : 1994) 1994;1(2):129-35.
1994: Yimin Qian; Michelle A Blaskovich; M Saleem; C M Seong; S P Wathen; Andrew D Hamilton; Said M Sebti
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.
The Journal of biological chemistry 1994;269(17):12410-3.
1994: John Lazo; Said M Sebti
Bleomycin.
Cancer chemotherapy and biological response modifiers 1994;15():44-50.
1993: Terence F Mcguire; Seth J Corey; Said M Sebti
Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor.
The Journal of biological chemistry 1993;268(30):22227-30.
1993: M Nigam; C M Seong; Yimin Qian; Andrew D Hamilton; Said M Sebti
Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.
The Journal of biological chemistry 1993;268(28):20695-8.
1993: John Lazo; Said M Sebti
Bleomycins.
Cancer chemotherapy and biological response modifiers 1993;14():37-44.
1992: G Morris; J S Mistry; J P Jani; J E Mignano; Said M Sebti; John Lazo
Neutralization of bleomycin hydrolase by an epitope-specific antibody.
Molecular pharmacology 1992;42(1):57-62.
1992: J P Jani; J S Mistry; G Morris; P Davies; John Lazo; Said M Sebti
In vivo circumvention of human colon carcinoma resistance to bleomycin.
Cancer research 1992;52(10):2931-7.
1992: J S Mistry; J P Jani; G Morris; R B Mujumdar; I J Reynolds; Said M Sebti; John Lazo
Synthesis and evaluation of fluoromycin: a novel fluorescence-labeled derivative of talisomycin S10b.
Cancer research 1992;52(3):709-18.
1992: J P Jani; J S Mistry; G Morris; John Lazo; Said M Sebti
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64.
Oncology research 1992;4(2):59-63.
1991: G Morris; J S Mistry; J P Jani; Said M Sebti; John Lazo
Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells.
Biochemical pharmacology 1991;41(11):1559-66.
1991: Said M Sebti; G T Tkalcevic; J P Jani
Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
Cancer communications 1991;3(5):141-7.
1991: Said M Sebti; J P Jani; J S Mistry; Elieser Gorelik; John Lazo
Metabolic inactivation: a mechanism of human tumor resistance to bleomycin.
Cancer research 1991;51(1):227-32.
1990: J S Mistry; Said M Sebti; John Lazo
Separation of bleomycins and their deamido metabolites by high-performance cation-exchange chromatography.
Journal of chromatography 1990;514(1):86-90.
1990: John Lazo; DG Hoyt; Said M Sebti; Bruce R Pitt
Bleomycin: a pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis.
Pharmacology & therapeutics 1990;47(3):347-58.
1989: Said M Sebti; J E Mignano; J P Jani; S Srimatkandada; John Lazo
Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family.
Biochemistry 1989;28(16):6544-8.
1989: Said M Sebti; J C DeLeon; L T Ma; Sidney Hecht; John Lazo
Substrate specificity of bleomycin hydrolase.
Biochemical pharmacology 1989;38(1):141-7.
1988: Said M Sebti; John Lazo
Metabolic inactivation of bleomycin analogs by bleomycin hydrolase.
Pharmacology & therapeutics 1988;38(3):321-9.
1987: Said M Sebti; J C DeLeon; John Lazo
Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase.
Biochemistry 1987;26(14):4213-9.