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Jonathan Seckl

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Pregnancy

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Disorders

Prenatal Exposure Delayed Effects

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Co-Publications
Name
29
Chapman, Karen
24
Mullins, John
24
Walker, Brian
23
Holmes, Megan
21
Yau, Joyce
19
Morton, Nicholas
14
Noble, June
14
Kenyon, Christopher
9
Kotelevtsev, Yuri
9
Andrew, Ruth
9
Paterson, Janice
8
MacLullich, Alasdair
7
Lyons, Val
7
Deary, Ian
6
Hibberd, Carina

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Publications

TOP 3
Sai Shuji; Nakagawa Yuichi; Sakaguchi Kimiyoshi; Okada Shuichi; Takahashi Hiroyoshi; Hongo Teruaki; Seckl Jonathan R; Chapman Karen E; Ohzeki Takehiko
Differential regulation of 11beta-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia.
Drake Amanda J; van den Driesche Sander; Scott Hayley M; Hutchison Gary R; Seckl Jonathan R; Sharpe Richard M
Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.
Räikkönen Katri; Pesonen Anu-Katriina; Heinonen Kati; Lahti Jari; Komsi Niina; Eriksson Johan G; Seckl Jonathan R; Järvenpää Anna-Liisa; Strandberg Timo E
Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children.

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All Publications

2009: Sai Shuji; Nakagawa Yuichi; Sakaguchi Kimiyoshi; Okada Shuichi; Takahashi Hiroyoshi; Hongo Teruaki; Seckl Jonathan R; Chapman Karen E; Ohzeki Takehiko
Differential regulation of 11beta-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia.
Leukemia research 2009;33(12):1696-8.
2009: Drake Amanda J; van den Driesche Sander; Scott Hayley M; Hutchison Gary R; Seckl Jonathan R; Sharpe Richard M
Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.
Endocrinology 2009;150(11):5055-64.
2009: Räikkönen Katri; Pesonen Anu-Katriina; Heinonen Kati; Lahti Jari; Komsi Niina; Eriksson Johan G; Seckl Jonathan R; Järvenpää Anna-Liisa; Strandberg Timo E
Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children.
American journal of epidemiology 2009;170(9):1137-46.
2009: Carter R N; Paterson J M; Tworowska U; Stenvers D J; Mullins J J; Seckl J R; Holmes M C
Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent.
Journal of neuroendocrinology 2009;21(11):879-87.
2009: Yehuda Rachel; Bierer Linda M; Sarapas Casey; Makotkine Iouri; Andrew Ruth; Seckl Jonathan R
Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001.
Psychoneuroendocrinology 2009;34(9):1304-13.
2009: Goedecke Julia H; Levitt Naomi S; Lambert Estelle V; Utzschneider Kristina M; Faulenbach Mirjam V; Dave Joel A; West Sacha; Victor Hendriena; Evans Juliet; Olsson Tommy; Walker Brian R; Seckl Jonathan R; Kahn Steven E
Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women.
Obesity (Silver Spring, Md.) 2009;17(8):1506-12.
2009: Kang Peng; Rogalska Justyna; Walker Catherine A; Burke Matthew; Seckl Jonathan R; Macleod Malcolm R; Lai Maggie
Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant.
Molecular and cellular endocrinology 2009;305(1-2):56-62.
2009: Yehuda Rachel; Bierer Linda M; Andrew Ruth; Schmeidler James; Seckl Jonathan R
Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors.
Journal of psychiatric research 2009;43(9):877-83.
2009: Goedecke Julia H; Dave Joel A; Faulenbach Mirjam V; Utzschneider Kristina M; Lambert Estelle V; West Sacha; Collins Malcolm; Olsson Tommy; Walker Brian R; Seckl Jonathan R; Kahn Steven E; Levitt Naomi S
Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African women.
Diabetes care 2009;32(5):860-5.
2009: de Vries A; Hazlewood L; Fitch P M; Seckl J R; Foster P; Howie S E M
High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(5):731-9.
2009: Lai M; Bae S-E; Bell J E; Seckl J R; Macleod M R
Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia.
Neuropathology and applied neurobiology 2009;35(2):156-64.
2009: Chapman Karen E; Coutinho Agnes E; Gray Mohini; Gilmour James S; Savill John S; Seckl Jonathan R
The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response.
Molecular and cellular endocrinology 2009;301(1-2):123-31.
2009: Wyrwoll Caitlin S; Seckl Jonathan R; Holmes Megan C
Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice.
Endocrinology 2009;150(3):1287-93.
2009: Nyirenda Moffat J; Tang Justin I; Padfield Paul L; Seckl Jonathan R
Hyperkalaemia.
BMJ (Clinical research ed.) 2009;339():b4114.
2009: Cottrell Elizabeth C; Seckl Jonathan R
Prenatal stress, glucocorticoids and the programming of adult disease.
Frontiers in behavioral neuroscience 2009;3():19.
2008: Wamil Malgorzata; Andrew Ruth; Chapman Karen E; Street Jonathan; Morton Nicholas M; Seckl Jonathan R
7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.
Endocrinology 2008;149(12):5909-18.
2008: Michailidou Z; Carter R N; Marshall E; Sutherland H G; Brownstein D G; Owen E; Cockett K; Kelly V; Ramage L; Al-Dujaili E A S; Ross M; Maraki I; Newton K; Holmes M C; Seckl J R; Morton N M; Kenyon C J; Chapman K E
Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(11):3896-907.
2008: Sai Shuji; Esteves Cristina L; Kelly Val; Michailidou Zoi; Anderson Karen; Coll Anthony P; Nakagawa Yuichi; Ohzeki Takehiko; Seckl Jonathan R; Chapman Karen E
Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta.
Molecular endocrinology (Baltimore, Md.) 2008;22(9):2049-60.
2008: MacLullich Alasdair M J; Seckl Jonathan R
Diabetes and cognitive decline: are steroids the missing link?
Cell metabolism 2008;7(4):286-7.
2008: De Sousa Peixoto R A; Turban S; Battle J H; Chapman K E; Seckl J R; Morton N M
Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.
Endocrinology 2008;149(4):1861-8.
2008: Chapman Karen E; Seckl Jonathan R
11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function.
Neurochemical research 2008;33(4):624-36.
2008: O'Regan David; Kenyon Christopher J; Seckl Jonathan R; Holmes Megan C
Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring.
The Journal of endocrinology 2008;196(2):343-52.
2008: Ye Ping; Kenyon Christopher J; Mackenzie Scott M; Nichol Katherine; Seckl Jonathan R; Fraser Robert; Connell John M C; Davies Eleanor
Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system.
The Journal of endocrinology 2008;196(2):305-11.
2008: Bailey Matthew A; Paterson Janice M; Hadoke Patrick W F; Wrobel Nicola; Bellamy Christopher O C; Brownstein David G; Seckl Jonathan R; Mullins John J
A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.
Journal of the American Society of Nephrology : JASN 2008;19(1):47-58.
2008: Morton Nicholas M; Seckl Jonathan R
11beta-hydroxysteroid dehydrogenase type 1 and obesity.
Frontiers of hormone research 2008;36():146-64.
2008: Seckl Jonathan R
Glucocorticoids, developmental 'programming' and the risk of affective dysfunction.
Progress in brain research 2008;167():17-34.
2007: Yau Joyce L W; Noble June; Thomas Sarah; Kerwin Robert; Morgan Phillip E; Lightman Stafford; Seckl Jonathan R; Pariante Carmine M
The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(12):2520-9.
2007: Yau Joyce L W; McNair Kara M; Noble June; Brownstein David; Hibberd Carina; Morton Nik; Mullins John J; Morris Richard G M; Cobb Stuart; Seckl Jonathan R
Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10487-96.
2007: Wamil Malgorzata; Seckl Jonathan R
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target.
Drug discovery today 2007;12(13-14):504-20.
2007: Michailidou Zoi; Coll Anthony P; Kenyon Christopher J; Morton Nicholas M; O'Rahilly Stephen; Seckl Jonathan R; Chapman Karen E
Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.
The Journal of endocrinology 2007;194(1):161-70.
2007: Seckl Jonathan R; Holmes Megan C
Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology.
Nature clinical practice. Endocrinology & metabolism 2007;3(6):479-88.
2007: Michailidou Zoi; Jensen Michael D; Dumesic Daniel A; Chapman Karen E; Seckl Jonathan R; Walker Brian R; Morton Nicholas M
Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.
Obesity (Silver Spring, Md.) 2007;15(5):1155-63.
2007: Webster Scott P; Ward Peter; Binnie Margaret; Craigie Eilidh; McConnell Kirsty M M; Sooy Karen; Vinter Andy; Seckl Jonathan R; Walker Brian R
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2838-43.
2007: Sheward W John; Maywood Elizabeth S; French Karen L; Horn Jacqueline M; Hastings Michael H; Seckl Jonathan R; Holmes Megan C; Harmar Anthony J
Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4351-8.
2007: de Vries Annick; Holmes Megan C; Heijnis Areke; Seier Jürgen V; Heerden Joritha; Louw Johan; Wolfe-Coote Sonia; Meaney Michael J; Levitt Naomi S; Seckl Jonathan R
Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function.
The Journal of clinical investigation 2007;117(4):1058-67.
2007: Lai Maggie; Horsburgh Karen; Bae Sung-Eun; Carter Roderick N; Stenvers Dirk J; Fowler Jill H; Yau Joyce L; Gomez-Sanchez Celso E; Holmes Megan C; Kenyon Christopher J; Seckl Jonathan R; Macleod Malcolm R
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.
The European journal of neuroscience 2007;25(6):1832-42.
2007: Paterson Janice M; Holmes Megan C; Kenyon Christopher J; Carter Roderick; Mullins John J; Seckl Jonathan R
Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Endocrinology 2007;148(3):961-6.
2006: Chapman Karen E; Coutinho Agnes; Gray Mohini; Gilmour James S; Savill John S; Seckl Jonathan R
Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response.
Annals of the New York Academy of Sciences 2006;1088():265-73.
2006: Yau Joyce L W; Noble June; Graham Mags; Seckl Jonathan R
Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):11034-40.
2006: Densmore Valerie S; Morton Nicholas M; Mullins John J; Seckl Jonathan R
11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
Endocrinology 2006;147(9):4486-95.
2006: Seckl Jonathan R; Meaney Michael J
Glucocorticoid "programming" and PTSD risk.
Annals of the New York Academy of Sciences 2006;1071():351-78.
2006: Goedecke J H; Wake D J; Levitt N S; Lambert E V; Collins M R; Morton N M; Andrew R; Seckl J R; Walker B R
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women.
Clinical endocrinology 2006;65(1):81-7.
2006: Raubenheimer Peter J; Young Elizabeth A; Andrew Ruth; Seckl Jonathan R
The role of corticosterone in human hypothalamic-pituitary-adrenal axis feedback.
Clinical endocrinology 2006;65(1):22-6.
2006: Gilmour James S; Coutinho Agnes E; Cailhier Jean-François; Man Tak Yung; Clay Michael; Thomas Graham; Harris Hayley J; Mullins John J; Seckl Jonathan R; Savill John S; Chapman Karen E
Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7605-11.
2006: Nyirenda M J; Dean S; Lyons V; Chapman K E; Seckl J R
Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'?
Diabetologia 2006;49(6):1412-20.
2006: Bruley Charlotte; Lyons Val; Worsley Alan G F; Wilde Margaret D; Darlington Gretchen D; Morton Nik M; Seckl Jonathan R; Chapman Karen E
A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent.
Endocrinology 2006;147(6):2879-85.
2006: Holmes Megan C; Abrahamsen Christian T; French Karen L; Paterson Janice M; Mullins John J; Seckl Jonathan R
The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3840-4.
2006: MacLullich Alasdair M J; Ferguson Karen J; Wardlaw Joanna M; Starr John M; Deary Ian J; Seckl Jonathan R
Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men.
The Journal of clinical endocrinology and metabolism 2006;91(4):1591-4.
2006: Reynolds Rebecca M; Padfield Paul L; Seckl Jonathan R
Disorders of sodium balance.
BMJ (Clinical research ed.) 2006;332(7543):702-5.
2006: Hadoke P W F; Lindsay R S; Seckl J R; Walker B R; Kenyon C J
Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure.
The Journal of endocrinology 2006;188(3):435-42.
2006: Holmes Megan C; Seckl Jonathan R
The role of 11beta-hydroxysteroid dehydrogenases in the brain.
Molecular and cellular endocrinology 2006;248(1-2):9-14.
2006: Chapman Karen E; Gilmour James S; Coutinho Agnes E; Savill John S; Seckl Jonathan R
11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation?
Molecular and cellular endocrinology 2006;248(1-2):3-8.
2006: Holmes M C; Sangra M; French K L; Whittle I R; Paterson J; Mullins J J; Seckl J R
11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids.
Neuroscience 2006;137(3):865-73.
2006: Reynolds Rebecca M; Stewart Paul M; Seckl Jonathan R; Padfield Paul L
Assessing the HPA axis in patients with pituitary disease: a UK survey.
Clinical endocrinology 2006;64(1):82-5.
2006: Deary Ian J; Hayward Caroline; Permana Paska A; Nair Saraswathy; Whalley Lawrence J; Starr John M; Chapman Karen E; Walker Brian R; Seckl Jonathan R
Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change.
Neuroscience letters 2006;393(1):74-7.
2005: Morton Nicholas M; Densmore Valerie; Wamil Malgorzata; Ramage Lynne; Nichol Katherine; Bünger Lutz; Seckl Jonathan R; Kenyon Christopher J
A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action.
Diabetes 2005;54(12):3371-8.
2005: Reynolds Rebecca M; Seckl Jonathan R
Hyponatraemia for the clinical endocrinologist.
Clinical endocrinology 2005;63(4):366-74.
2005: Paterson Janice M; Seckl Jonathan R; Mullins John J
Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(3):R642-52.
2005: Padfield P L; Seckl J R; Walker B R; Gleeson H K
Letter re: HPA axis testing after pituitary surgery.
The Journal of clinical endocrinology and metabolism 2005;90(8):4981-2.
2005: Levitt N S; Lambert E V; Woods D; Seckl J R; Hales C N
Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans.
Diabetologia 2005;48(6):1118-25.
2005: MacLullich Alasdair M J; Deary Ian J; Starr John M; Ferguson Karen J; Wardlaw Joanna M; Seckl Jonathan R
Plasma cortisol levels, brain volumes and cognition in healthy elderly men.
Psychoneuroendocrinology 2005;30(5):505-15.
2005: Kershaw Erin E; Morton Nicholas M; Dhillon Harveen; Ramage Lynne; Seckl Jonathan R; Flier Jeffrey S
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.
Diabetes 2005;54(4):1023-31.
2005: Drake Amanda J; Livingstone Dawn E W; Andrew Ruth; Seckl Jonathan R; Morton Nicholas M; Walker Brian R
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.
Endocrinology 2005;146(2):913-9.
2005: McAulay Vincent; Seckl Jonathan R; Strachan Mark W J
Recurrent dizzy spells: all in the head!
Annals of clinical biochemistry 2005;42(Pt 1):78-9.
2005: Drake Amanda J; Walker Brian R; Seckl Jonathan R
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(1):R34-8.
2004: Seckl Jonathan R; Meaney Michael J
Glucocorticoid programming.
Annals of the New York Academy of Sciences 2004;1032():63-84.
2004: Seckl Jonathan R
11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.
Current opinion in pharmacology 2004;4(6):597-602.
2004: MacLullich Alasdair M J; Edmond C Louise; Ferguson Karen J; Wardlaw Joanna M; Starr John M; Seckl Jonathan R; Deary Ian J
Size of the neocerebellar vermis is associated with cognition in healthy elderly men.
Brain and cognition 2004;56(3):344-8.
2004: Seckl Jonathan R
Prenatal glucocorticoids and long-term programming.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151 Suppl 3():U49-62.
2004: Freeman Alistair I; Munn Helen L; Lyons Val; Dammermann Alexander; Seckl Jonathan R; Chapman Karen E
Glucocorticoid down-regulation of rat glucocorticoid receptor does not involve differential promoter regulation.
The Journal of endocrinology 2004;183(2):365-74.
2004: Seckl Jonathan R; Walker Brian R
11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory.
Trends in endocrinology and metabolism: TEM 2004;15(9):418-24.
2004: O'Regan D; Kenyon C J; Seckl J R; Holmes M C
Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E863-70.
2004: Yau Joyce L W; Noble June; Chapman Karen E; Seckl Jonathan R
Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine.
Brain research. Molecular brain research 2004;129(1-2):189-92.
2004: Morton Nicholas M; Ramage Lynne; Seckl Jonathan R
Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease.
Endocrinology 2004;145(6):2707-12.
2004: Paterson Janice M; Morton Nicholas M; Fievet Catherine; Kenyon Christopher J; Holmes Megan C; Staels Bart; Seckl Jonathan R; Mullins John J
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7088-93.
2004: Somponpun S J; Holmes M C; Seckl J R; Russell J A
Modulation of oestrogen receptor-beta mRNA expression in rat paraventricular and supraoptic nucleus neurones following adrenal steroid manipulation and hyperosmotic stimulation.
Journal of neuroendocrinology 2004;16(5):472-82.
2004: Speirs H J L; Seckl J R; Brown R W
Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development.
The Journal of endocrinology 2004;181(1):105-16.
2004: Sandeep Thekkepat C; Yau Joyce L W; MacLullich Alasdair M J; Noble June; Deary Ian J; Walker Brian R; Seckl Jonathan R
11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6734-9.
2004: Morton Nicholas M; Paterson Janice M; Masuzaki Hiroaki; Holmes Megan C; Staels Bart; Fievet Catherine; Walker Brian R; Flier Jeffrey S; Mullins John J; Seckl Jonathan R
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: Seckl Jonathan R; Morton Nik M; Chapman Karen E; Walker Brian R
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.
Recent progress in hormone research 2004;59():359-93.
2003: Holmes Megan C; Yau Joyce L W; Kotelevtsev Yuri; Mullins John J; Seckl Jonathan R
11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles.
Annals of the New York Academy of Sciences 2003;1007():357-66.
2003: Stokes John; Walker Brian R; Campbell Jill C; Seckl Jonathan R; O'Brien Colm; Andrew Ruth
Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma.
Investigative ophthalmology & visual science 2003;44(12):5163-7.
2003: Westerbacka Jukka; Yki-Järvinen Hannele; Vehkavaara Satu; Häkkinen Anna-Maija; Andrew Ruth; Wake Deborah J; Seckl Jonathan R; Walker Brian R
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
The Journal of clinical endocrinology and metabolism 2003;88(10):4924-31.
2003: Christy Clare; Hadoke Patrick W F; Paterson Janice M; Mullins John J; Seckl Jonathan R; Walker Brian R
11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids.
Hypertension 2003;42(4):580-7.
2003: Lavery Gareth G; Ronconi Vanessa; Draper Nicole; Rabbitt Elizabeth H; Lyons Val; Chapman Karen E; Walker Elizabeth A; McTernan Claire L; Giacchetti Gilberta; Mantero Franco; Seckl Jonathan R; Edwards Christopher R W; Connell John M C; Hewison Martin; Stewart Paul M
Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene.
Hypertension 2003;42(2):123-9.
2003: Masuzaki Hiroaki; Yamamoto Hiroshi; Kenyon Christopher J; Elmquist Joel K; Morton Nicholas M; Paterson Janice M; Shinyama Hiroshi; Sharp Matthew G F; Fleming Stewart; Mullins John J; Seckl Jonathan R; Flier Jeffrey S
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
The Journal of clinical investigation 2003;112(1):83-90.
2003: Mattsson Cecilia; Lai Maggie; Noble June; McKinney Eoin; Yau Joyce L; Seckl Jonathan R; Walker Brian R
Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity.
Endocrinology 2003;144(7):2997-3003.
2003: Gleeson Helena K; Walker Brian R; Seckl Jonathan R; Padfield Paul L
Ten years on: Safety of short synacthen tests in assessing adrenocorticotropin deficiency in clinical practice.
The Journal of clinical endocrinology and metabolism 2003;88(5):2106-11.
2003: Macleod Malcolm R; Johansson Inga-Maj; Söderström Ingegerd; Lai Maggie; Gidö Gunilla; Wieloch Tadeusz; Seckl Jonathan R; Olsson Tommy
Mineralocorticoid receptor expression and increased survival following neuronal injury.
The European journal of neuroscience 2003;17(8):1549-55.
2003: Brown Pamela; Scobie Graeme A; Townsend Julie; Bayne Rosemary A L; Seckl Jonathan R; Saunders Philippa T K; Anderson Richard A
Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation.
The Journal of clinical endocrinology and metabolism 2003;88(3):1341-9.
2003: Cleasby Mark E; Kelly Paul A T; Walker Brian R; Seckl Jonathan R
Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids.
Endocrinology 2003;144(3):999-1007.
2003: Macleod Malcolm R; Ramage Lynne; McGregor Ailsa; Seckl Jonathan R
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein.
Neuroreport 2003;14(2):215-7.
2003: Cleasby Mark E; Livingstone Dawn E W; Nyirenda Moffat J; Seckl Jonathan R; Walker Brian R
Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(1):129-38.
2003: Yau J L W; Rasmuson S; Andrew R; Graham M; Noble J; Olsson T; Fuchs E; Lathe R; Seckl J R
Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.
Neuroscience 2003;121(2):307-14.
2003: Lai M; McCormick J A; Chapman K E; Kelly P A T; Seckl J R; Yau J L W
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.
Neuroscience 2003;118(4):975-84.
2002: Ferguson Karen J; MacLullich Alasdair M J; Marshall Ian; Deary Ian J; Starr John M; Seckl Jonathan R; Wardlaw Joanna M
Magnetic resonance spectroscopy and cognitive function in healthy elderly men.
Brain : a journal of neurology 2002;125(Pt 12):2743-9.
2002: Seckl Jonathan R; Yau Joyce; Holmes Megan
11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain.
Endocrine research 2002;28(4):701-7.
2002: Hundertmark S; Dill A; Ebert A; Zimmermann B; Kotelevtsev Y V; Mullins J J; Seckl J R
Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(10):545-9.
2002: Hundertmark S; Dill A; Bühler H; Stevens P; Looman K; Ragosch V; Seckl J R; Lipka C
11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(10):537-44.
2002: Yau Joyce L W; Hibberd Carina; Noble June; Seckl Jonathan R
The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats.
Brain research. Molecular brain research 2002;106(1-2):117-23.
2002: MacLullich A M J; Ferguson K J; Deary I J; Seckl J R; Starr J M; Wardlaw J M
Intracranial capacity and brain volumes are associated with cognition in healthy elderly men.
Neurology 2002;59(2):169-74.
2002: Hou Jianghui; Speirs Helen J L; Seckl Jonathan R; Brown Roger W
Sgk1 gene expression in kidney and its regulation by aldosterone: spatio-temporal heterogeneity and quantitative analysis.
Journal of the American Society of Nephrology : JASN 2002;13(5):1190-8.
2002: Yau Joyce L W; Noble June; Hibberd Carina; Rowe Wayne B; Meaney Michael J; Morris Richard G M; Seckl Jonathan R
Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(4):1436-42.
2001: Masuzaki H; Paterson J; Shinyama H; Morton N M; Mullins J J; Seckl J R; Flier J S
A transgenic model of visceral obesity and the metabolic syndrome.
Science (New York, N.Y.) 2001;294(5549):2166-70.
2001: Seckl J R
Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms.
Molecular and cellular endocrinology 2001;185(1-2):61-71.
2001: Hadoke P W; Christy C; Kotelevtsev Y V; Williams B C; Kenyon C J; Seckl J R; Mullins J J; Walker B R
Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase.
Circulation 2001;104(23):2832-7.
2001: Yau J L; Seckl J R
11beta-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup.
Molecular psychiatry 2001;6(6):611-4.
2001: Morton N M; Holmes M C; Fiévet C; Staels B; Tailleux A; Mullins J J; Seckl J R
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.
The Journal of biological chemistry 2001;276(44):41293-300.
2001: Nyirenda M J; Welberg L A; Seckl J R
Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence?
The Journal of endocrinology 2001;170(3):653-60.
2001: Yau J L; Noble J; Seckl J R
Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus.
Neuroscience letters 2001;309(3):141-4.
2001: Yau J L; Noble J; Hibberd C; Seckl J R
Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus.
Neuroscience letters 2001;306(3):161-4.
2001: Rose K; Allan A; Gauldie S; Stapleton G; Dobbie L; Dott K; Martin C; Wang L; Hedlund E; Seckl J R; Gustafsson J A; Lathe R
Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.
The Journal of biological chemistry 2001;276(26):23937-44.
2001: Martin C; Bean R; Rose K; Habib F; Seckl J
cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate.
The Biochemical journal 2001;355(Pt 2):509-15.
2001: Yau J L; Noble J; Kenyon C J; Hibberd C; Kotelevtsev Y; Mullins J J; Seckl J R
Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4716-21.
2001: Seckl J R; Walker B R
Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action.
Endocrinology 2001;142(4):1371-6.
2001: Bean R; Seckl J R; Lathe R; Martin C
Ontogeny of the neurosteroid enzyme Cyp7b in the mouse.
Molecular and cellular endocrinology 2001;174(1-2):137-44.
2001: Gray G A; Sharif I; Webb D J; Seckl J R
Oestrogen and the cardiovascular system: the good, the bad and the puzzling.
Trends in pharmacological sciences 2001;22(3):152-6.
2001: Hundertmark S; Bühler H; Fromm M; Kruner-Gareis B; Kruner M; Ragosch V; Kuhlmann K; Seckl J R
Ontogeny of 11beta-hydroxysteroid dehydrogenase: activity in the placenta, kidney, colon of fetal rats and rabbits.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(2):78-83.
2001: Welberg L A; Seckl J R
Prenatal stress, glucocorticoids and the programming of the brain.
Journal of neuroendocrinology 2001;13(2):113-28.
2001: Holmes M C; Kotelevtsev Y; Mullins J J; Seckl J R
Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes.
Molecular and cellular endocrinology 2001;171(1-2):15-20.
2001: Harris H J; Kotelevtsev Y; Mullins J J; Seckl J R; Holmes M C
Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice.
Endocrinology 2001;142(1):114-20.
2001: Welberg L A; Seckl J R; Holmes M C
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour.
Neuroscience 2001;104(1):71-9.
2000: Levitt N S; Lambert E V; Woods D; Hales C N; Andrew R; Seckl J R
Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: early programming of cortisol axis.
The Journal of clinical endocrinology and metabolism 2000;85(12):4611-8.
2000: Hibberd C; Yau J L; Seckl J R
Glucocorticoids and the ageing hippocampus.
Journal of anatomy 2000;197 Pt 4():553-62.
2000: Marshall I; Bruce S D; Higinbotham J; MacLullich A; Wardlaw J M; Ferguson K J; Seckl J
Choice of spectroscopic lineshape model affects metabolite peak areas and area ratios.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(4):646-9.
2000: Williams L J; Lyons V; MacLeod I; Rajan V; Darlington G J; Poli V; Seckl J R; Chapman K E
C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.
The Journal of biological chemistry 2000;275(39):30232-9.
2000: Seckl J R
Glucocorticoids, ageing and nerve cell damage.
Journal of neuroendocrinology 2000;12(8):709-10.
2000: Stokes J; Noble J; Brett L; Phillips C; Seckl J R; O'Brien C; Andrew R
Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.
Investigative ophthalmology & visual science 2000;41(7):1629-38.
2000: Jamieson P M; Walker B R; Chapman K E; Andrew R; Rossiter S; Seckl J R
11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver.
The Journal of endocrinology 2000;165(3):685-92.
2000: Seckl J R; Cleasby M; Nyirenda M J
Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming.
Kidney international 2000;57(4):1412-7.
2000: MacDonald P; MacKenzie S; Ramage L E; Seckl J R; Brown R W
Corticosteroid regulation of amiloride-sensitive sodium-channel subunit mRNA expression in mouse kidney.
The Journal of endocrinology 2000;165(1):25-37.
2000: Welberg L A; Seckl J R; Holmes M C
Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring.
The European journal of neuroscience 2000;12(3):1047-54.
1999: Yau J L; Noble J; Seckl J R
Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats.
Neuroscience letters 1999;277(1):45-8.
1999: Yau J L; Olsson T; Noble J; Seckl J R
Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment.
Brain research. Molecular brain research 1999;70(2):282-7.
1999: Jamieson P M; Chapman K E; Seckl J R
Tissue- and temporal-specific regulation of 11beta-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo.
The Journal of steroid biochemistry and molecular biology 1999;68(5-6):245-50.
1999: Kotelevtsev Y; Brown R W; Fleming S; Kenyon C; Edwards C R; Seckl J R; Mullins J J
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.
The Journal of clinical investigation 1999;103(5):683-9.
1999: Seckl J R; Nyirenda M J; Walker B R; Chapman K E
Glucocorticoids and fetal programming.
Biochemical Society transactions 1999;27(2):74-8.
1999: Yau J L; Kelly P A; Olsson T; Noble J; Seckl J R
Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats.
Neuroscience letters 1999;261(3):183-5.
1999: Jamieson P M; Nyirenda M J; Walker B R; Chapman K E; Seckl J R
Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1.
The Journal of endocrinology 1999;160(1):103-9.
1998: Seckl J R
Physiologic programming of the fetus.
Clinics in perinatology 1998;25(4):939-62, vii.
1998: Nyirenda M J; Seckl J R
Intrauterine events and the programming of adulthood disease: the role of fetal glucocorticoid exposure (Review).
International journal of molecular medicine 1998;2(5):607-14.
1998: Leckie C M; Welberg L A; Seckl J R
11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells.
The Journal of endocrinology 1998;159(2):233-8.
1998: Robson A C; Leckie C M; Seckl J R; Holmes M C
11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain.
Brain research. Molecular brain research 1998;61(1-2):1-10.
1998: McCormick J A; Lyons V; Noble J; Ester W; Meaney M J; Seckl J R; Chapman K E
Tissue-specific differences in rat glucocorticoid receptor gene transcriptional regulation.
Biochemical Society transactions 1998;26(3):S207.
1998: Martin C; Chapman K E; Seckl J R; Ashley R H
Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.
Neuroscience 1998;85(1):205-16.
1998: Nyirenda M J; Lindsay R S; Kenyon C J; Burchell A; Seckl J R
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring.
The Journal of clinical investigation 1998;101(10):2174-81.
1998: Diaz R; Brown R W; Seckl J R
Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(7):2570-80.
1998: Napolitano A; Voice M W; Edwards C R; Seckl J R; Chapman K E
11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):251-60.
1997: Kotelevtsev Y; Holmes M C; Burchell A; Houston P M; Schmoll D; Jamieson P; Best R; Brown R; Edwards C R; Seckl J R; Mullins J J
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14924-9.
1997: Benediktsson R; Magnusdottir E M; Seckl J R
Lack of effect of nicotine or ethanol on the activity of 11beta-hydroxysteroid dehydrogenase type 2.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):303-7.
1997: Holmes M C; French K L; Seckl J R
Dysregulation of diurnal rhythms of serotonin 5-HT2C and corticosteroid receptor gene expression in the hippocampus with food restriction and glucocorticoids.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4056-65.
1997: Williams L J; Lyons V; Wallace R; Seckl J R; Chapman K E
CCAAT/enhancer binding protein positively regulates the rat 11 beta-hydroxysteroid dehydrogenase type 1 promoter in liver cells.
Biochemical Society transactions 1997;25(2):235S.
1997: Chapman K E; Kotelevtsev Y V; Jamieson P M; Williams L J; Mullins J J; Seckl J R
Tissue-specific modulation of glucocorticoid action by the 11 beta-hydroxysteroid dehydrogenases.
Biochemical Society transactions 1997;25(2):583-7.
1997: Rose K A; Stapleton G; Dott K; Kieny M P; Best R; Schwarz M; Russell D W; Björkhem I; Seckl J; Lathe R
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):4925-30.
1997: Yau J L; Noble J; Widdowson J; Seckl J R
Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus.
Brain research. Molecular brain research 1997;45(1):182-6.
1997: Seckl J R; Miller W L
How safe is long-term prenatal glucocorticoid treatment?
JAMA : the journal of the American Medical Association 1997;277(13):1077-9.
1997: Benediktsson R; Calder A A; Edwards C R; Seckl J R
Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure.
Clinical endocrinology 1997;46(2):161-6.
1997: Seckl J R
Glucocorticoids, feto-placental 11 beta-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease.
Steroids 1997;62(1):89-94.
1997: Seckl J R
11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?
Frontiers in neuroendocrinology 1997;18(1):49-99.
1990: Moisan M P; Seckl J R; Brett L P; Monder C; Agarwal A K; White P C; Edwards C R
11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression, Bioactivity and Immunoreactivity in Rat Cerebellum.
Journal of neuroendocrinology 1990;2(6):853-8.

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