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Christopher Secombes

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Ronggai Li; Steve Bird; Helen Dooley; Tiehui Wang; Jun Zou; Christopher J Secombes
B cell receptor accessory molecule CD79α: Characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).
D Pacitti; M M Page; J Feldmann; S A M Martin; J Sweetman; Tiehui Wang; Christopher J Secombes
Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure.
Tiehui Wang; Maria M Costa; Mansourah Husain; Tomoya Kono; Hiroki Korenaga; Haruka Kuse; Tanja Maehr; Milena M Monte; Masahiro Sakai; Christopher J Secombes
Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor.

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All Publications

2013: Ronggai Li; Steve Bird; Helen Dooley; Tiehui Wang; Jun Zou; Christopher J Secombes
B cell receptor accessory molecule CD79α: Characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).
Fish & shellfish immunology 2013;34(6):1404-15.
2013: D Pacitti; M M Page; J Feldmann; S A M Martin; J Sweetman; Tiehui Wang; Christopher J Secombes
Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure.
Aquatic toxicology (Amsterdam, Netherlands) 2013;130-131():97-111.
2013: Tiehui Wang; Maria M Costa; Mansourah Husain; Tomoya Kono; Hiroki Korenaga; Haruka Kuse; Tanja Maehr; Milena M Monte; Masahiro Sakai; Christopher J Secombes
Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor.
Molecular immunology 2013;53(4):398-409.
2013: Elisa Casadei; Simon Wadsworth; Jose L González Vecino; Steve Bird; Christopher J Secombes
The effect of peptidoglycan enriched diets on antimicrobial peptide gene expression in rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2013;34(2):529-37.
2013: Ryusuke Nagamine; Masahiro Sakai; Christopher J Secombes; Hiroki Korenaga; Tomoya Kono
Characterization and expression analysis of Th-POK from the Japanese pufferfish, Takifugu rubripes.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2013;164(2):124-32.
2013: Tanja Maehr; Samuel A M Martin; Simon Wadsworth; Tiehui Wang; Jose L González Vecino; Maria M Costa; Christopher J Secombes
Transforming growth factor-β1b: a second TGF-β1 paralogue in the rainbow trout (Oncorhynchus mykiss) that has a lower constitutive expression but is more responsive to immune stimulation.
Fish & shellfish immunology 2013;34(2):420-32.
2013: Milena M Monte; Tiehui Wang; Jun Zou; Jason W Holland; Christopher J Secombes
Cloning and characterization of rainbow trout interleukin-17A/F2 (IL-17A/F2) and IL-17 receptor A: expression during infection and bioactivity of recombinant IL-17A/F2.
Infection and immunity 2013;81(1):340-53.
2012: Luca Tacchi; Christopher J Secombes; Ralph Bickerdike; Elisa Casadei; Samuel A M Martin
MULAN related gene (MRG): a potential novel ubiquitin ligase activator of NF-kB involved in immune response in Atlantic salmon (Salmo salar).
Developmental and comparative immunology 2012;38(4):545-53.
2012: Mansourah Husain; Christopher J Secombes; Steve Bird; Ruthger van Zwieten; Tiehui Wang
Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish.
Developmental and comparative immunology 2012;38(3):431-46.
2012: Irene de Bruijn; Marcia Saraiva; Vicky L Anderson; Rodrigo Belmonte; Pieter van West; Tiehui Wang; Christopher J Secombes
Immune gene expression in trout cell lines infected with the fish pathogenic oomycete Saprolegnia parasitica.
Developmental and comparative immunology 2012;38(1):44-54.
2012: Petronella Johansson; Christopher J Secombes; Tiehui Wang; Bertrand Collet; Y Corripio-Miyar; Jun Zou
Characterisation and expression analysis of the rainbow trout (Oncorhynchus mykiss) homologue of the human dendritic cell marker CD208/lysosomal associated membrane protein 3.
Developmental and comparative immunology 2012;37(3-4):402-13.
2012: Tanja Maehr; Simon Wadsworth; Tiehui Wang; Jose L González Vecino; Christopher J Secombes
Cloning and expression analysis of the transforming growth factor-beta receptors type 1 and 2 in the rainbow trout Oncorhynchus mykiss.
Developmental and comparative immunology 2012;37(1):115-26.
2012: Ronggai Li; Christopher J Secombes; Tiehui Wang; Helen Dooley; Steve Bird
Characterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): cartilaginous fish BAFF has a unique extra exon that may impact receptor binding.
Developmental and comparative immunology 2012;36(4):707-17.
2012: Maria M Costa; Milena M Monte; Tiehui Wang; Christopher J Secombes
Molecular characterization and expression analysis of the putative interleukin 6 receptor (IL-6Rα and glycoprotein-130) in rainbow trout (Oncorhynchus mykiss): salmonid IL-6Rα possesses a polymorphic N-terminal Ig domain with variable numbers of two repeats.
Immunogenetics 2012;64(3):229-44.
2012: Luca Tacchi; Harald Takle; Claudia Venegas; Michael A Adler; Ralph Bickerdike; Christopher J Secombes; Samuel A M Martin
Transcriptomic and physiological responses to fishmeal substitution with plant proteins in formulated feed in farmed Atlantic salmon (Salmo salar).
BMC genomics 2012;13():363.
2012: Andrew F Rowley; Jason W Holland; Elizabeth L Morgan; Graham W Taylor; Claire L Vogan; J Oriol Sunyer; Christopher J Secombes
Interaction between eicosanoids and the complement system in salmonid fish.
Developmental and comparative immunology 2012;36(1):1-9.
2011: Luca Tacchi; Christopher J Secombes; Ralph Bickerdike; Elisa Casadei; Samuel A M Martin
Cloning and expression analysis of the mitochondrial ubiquitin ligase activator of NF-κB (MULAN) in Atlantic salmon (Salmo salar).
Molecular immunology 2011;49(3):558-65.
2011: Luca Tacchi; John B Taggart; Harald Takle; Christopher J Secombes; Michael A Adler; Ralph Bickerdike; James Bron; Samuel A M Martin
Multiple tissue transcriptomic responses to Piscirickettsia salmonis in Atlantic salmon (Salmo salar).
Physiological genomics 2011;43(21):1241-54.
2011: Tiehui Wang; Maria M Costa; Wenshu Huang; Christopher J Secombes
The gamma-chain cytokine/receptor system in fish: more ligands and receptors.
Fish & shellfish immunology 2011;31(5):673-87.
2011: Luca Tacchi; Christopher J Secombes; Ralph Bickerdike; Alex Douglas; Samuel A M Martin
Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar).
Fish & shellfish immunology 2011;31(5):704-15.
2011: Maria M Costa; Patricia Diaz-Rosales; Tanja Maehr; Christopher J Secombes; Tiehui Wang
Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression.
Molecular immunology 2011;48(15-16):1903-16.
2011: Mingxian Chang; Bertrand Collet; Katherine Lester; Pin Nie; Christopher J Secombes; Scott Campbell; Jun Zou
Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss).
Journal of virology 2011;85(16):8403-12.
2011: Nor Omaima Harun; Maria M Costa; Christopher J Secombes; Tiehui Wang
Sequencing of a second interleukin-10 gene in rainbow trout Oncorhynchus mykiss and comparative investigation of the expression and modulation of the paralogues in vitro and in vivo.
Fish & shellfish immunology 2011;31(1):107-17.
2011: Tiehui Wang; Wenshu Huang; Maria M Costa; Samuel A M Martin; Christopher J Secombes
Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Rα, IL-13Rα1 and IL-13Rα2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation.
Immunogenetics 2011;63(4):235-53.
2011: D M Shewring; Jun Zou; Y Corripio-Miyar; Christopher J Secombes
Analysis of the cathelicidin 1 gene locus in Atlantic cod (Gadus morhua).
Molecular immunology 2011;48(5):782-7.
2011: Tiehui Wang; Patricia Diaz-Rosales; Maria M Costa; Scott Campbell; Michael Snow; Bertrand Collet; Samuel A M Martin; Christopher J Secombes
Functional characterization of a nonmammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-gamma, IL-10, and IL-22.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):708-21.
2011: S Campbell; A McBeath; Christopher J Secombes; M Snow; Bertrand Collet
Interferon response following infection with genetically similar isolates of viral haemorrhagic septicaemia virus (VHSV) exhibiting contrasting virulence in rainbow trout.
Fish & shellfish immunology 2011;30(1):287-94.
2011: Rosario Castro; Jun Zou; Christopher J Secombes; Samuel A M Martin
Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line.
Fish & shellfish immunology 2011;30(1):215-23.
2011: Mingxian Chang; Tiehui Wang; Pin Nie; Jun Zou; Christopher J Secombes
Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains.
Fish & shellfish immunology 2011;30(1):118-27.
2010: Luca Tacchi; Ralph Bickerdike; Christopher J Secombes; Nicholas J Pooley; Katy L Urquhart; Bertrand Collet; Samuel A M Martin
Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar): sequence analysis, genomic structure and modulation of expression.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2010;157(4):364-73.
2010: Tiehui Wang; Jason W Holland; Sam A M Martin; Christopher J Secombes
Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection.
Fish & shellfish immunology 2010;29(5):705-15.
2010: Tiehui Wang; Milena M Monte; Wenshu Huang; pierre boudinot; Samuel A M Martin; Christopher J Secombes
Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) with differential induction patterns.
Molecular immunology 2010;47(16):2563-74.
2010: Tiehui Wang; Qian Gao; Pin Nie; Christopher J Secombes
Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS.
Fish & shellfish immunology 2010;29(4):656-67.
2010: Jason W Holland; Asma Karim; Tiehui Wang; Ayham Alnabulsi; Jamie Scott; Bertrand Collet; Muhammad S Mughal; Christopher J Secombes; Steve Bird
Molecular cloning and characterization of interferon regulatory factors 4 and 8 (IRF-4 and IRF-8) in rainbow trout, Oncorhynchus mykiss.
Fish & shellfish immunology 2010;29(1):157-66.
2010: Tiehui Wang; Samuel A M Martin; Christopher J Secombes
Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated.
Developmental and comparative immunology 2010;34(5):491-500.
2010: Rosario Castro; Samuel A M Martin; Jun Zou; Christopher J Secombes
Establishment of an IFN-gamma specific reporter cell line in fish.
Fish & shellfish immunology 2010;28(2):312-9.
2010: Tiehui Wang; Patricia Díaz-Rosales; Sam A M Martin; Christopher J Secombes
Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family.
Developmental and comparative immunology 2010;34(2):158-67.
2010: Anders E Ostergaard; Krzysztof P Lubieniecki; Samuel A M Martin; René J M Stet; William S Davidson; Christopher J Secombes
Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family.
BMC genomics 2010;11():697.
2010: Samuel A M Martin; Alex Douglas; Dominic F Houlihan; Christopher J Secombes
Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar).
BMC genomics 2010;11():418.
2010: Suman Mitra; Ayham Alnabulsi; Christopher J Secombes; Steve Bird
Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio.
The FEBS journal 2010;277(1):128-47.
2009: Serena Ferraresso; Heiner Kuhl; Massimo Milan; David W Ritchie; Christopher J Secombes; Richard Reinhardt; Luca Bargelloni
Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection.
Immunogenetics 2009;61(11-12):773-88.
2009: S Campbell; Bertrand Collet; K Einer-Jensen; Christopher J Secombes; M Snow
Identifying potential virulence determinants in viral haemorrhagic septicaemia virus (VHSV) for rainbow trout.
Diseases of aquatic organisms 2009;86(3):205-12.
2009: Elisa Casadei; Tiehui Wang; Jun Zou; Jose L González Vecino; Simon Wadsworth; Christopher J Secombes
Characterization of three novel beta-defensin antimicrobial peptides in rainbow trout (Oncorhynchus mykiss).
Molecular immunology 2009;46(16):3358-66.
2009: P Díaz-Rosales; Steve Bird; T H Wang; K Fujiki; W S Davidson; Jun Zou; Christopher J Secombes
Rainbow trout interleukin-2: cloning, expression and bioactivity analysis.
Fish & shellfish immunology 2009;27(3):414-22.
2009: Q Gao; Pin Nie; K D Thompson; A Adams; Tiehui Wang; Christopher J Secombes; Jun Zou
The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss.
Developmental and comparative immunology 2009;33(8):920-31.
2009: Tiehui Wang; Steve Bird; Antonis Koussounadis; Jason W Holland; Allison C Carrington; Jun Zou; Christopher J Secombes
Identification of a novel IL-1 cytokine family member in teleost fish.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):962-74.
2009: Tiehui Wang; Christopher J Secombes
Identification and expression analysis of two fish-specific IL-6 cytokine family members, the ciliary neurotrophic factor (CNTF)-like and M17 genes, in rainbow trout Oncorhynchus mykiss.
Molecular immunology 2009;46(11-12):2290-8.
2009: Y Corripio-Miyar; Jun Zou; Heather Richmond; Christopher J Secombes
Identification of interleukin-22 in gadoids and examination of its expression level in vaccinated fish.
Molecular immunology 2009;46(10):2098-106.
2009: Mingxian Chang; Pin Nie; Bertrand Collet; Christopher J Secombes; Jun Zou
Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts.
Immunogenetics 2009;61(4):315-25.
2009: Anders E Østergaard; Samuel A M Martin; Tiehui Wang; René J M Stet; Christopher J Secombes
Rainbow trout (Oncorhynchus mykiss) possess multiple novel immunoglobulin-like transcripts containing either an ITAM or ITIMs.
Developmental and comparative immunology 2009;33(4):525-32.
2009: Daniela Casani; Elisa Randelli; Susan Costantini; Angelo M Facchiano; Jun Zou; Sam Martin; Christopher J Secombes; Giuseppe Scapigliati; Francesco Buonocore
Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.).
Molecular immunology 2009;46(5):943-52.
2008: Jason W Holland; Steve Bird; B Williamson; C Woudstra; A Mustafa; Tiehui Wang; Jun Zou; SC Blaney; Bertrand Collet; Christopher J Secombes
Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: functional analysis and transcriptional modulation.
Molecular immunology 2008;46(2):269-85.
2008: Christopher J Secombes
Will advances in fish immunology change vaccination strategies?
Fish & shellfish immunology 2008;25(4):409-16.
2008: Tiehui Wang; Patrick Hanington; Miodrag Belosevic; Christopher J Secombes
Two macrophage colony-stimulating factor genes exist in fish that differ in gene organization and are differentially expressed.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3310-22.
2008: Rosario Castro; S A M Martin; Steve Bird; Jesús Lamas; Christopher J Secombes
Characterisation of gamma-interferon responsive promoters in fish.
Molecular immunology 2008;45(12):3454-62.
2008: Francesco Buonocore; Elisa Randelli; Daniela Casani; Laura Guerra; Simona Picchietti; Susan Costantini; Angelo M Facchiano; Jun Zou; Christopher J Secombes; Giuseppe Scapigliati
A CD4 homologue in sea bass (Dicentrarchus labrax): molecular characterization and structural analysis.
Molecular immunology 2008;45(11):3168-77.
2008: Tomoya Kono; Steve Bird; Kohei Sonoda; Ram Savan; Christopher J Secombes; Masahiro Sakai
Characterization and expression analysis of an interleukin-7 homologue in the Japanese pufferfish, Takifugu rubripes.
The FEBS journal 2008;275(6):1213-26.
2008: Tiehui Wang; Christopher J Secombes
Rainbow trout suppressor of cytokine signalling (SOCS)-1, 2 and 3: molecular identification, expression and modulation.
Molecular immunology 2008;45(5):1449-57.
2008: Nor Omaima Harun; Jun Zou; Yong-An Zhang; Pin Nie; Christopher J Secombes
The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8.
Developmental and comparative immunology 2008;32(6):673-81.
2007: S A M Martin; John B Taggart; P Seear; James Bron; R Talbot; Alan J Teale; G E Sweeney; Bjørn Høyheim; Dominic F Houlihan; D R Tocher; J Zou; Christopher J Secombes
Interferon type I and type II responses in an Atlantic salmon (Salmo salar) SHK-1 cell line by the salmon TRAITS/SGP microarray.
Physiological genomics 2007;32(1):33-44.
2007: Jorunn B Jørgensen; Audny Johansen; Marit N Hegseth; Jun Zou; Børre Robertsen; Bertrand Collet; Christopher J Secombes
A recombinant CHSE-214 cell line expressing an Mx1 promoter-reporter system responds to both interferon type I and type II from salmonids and represents a versatile tool to study the IFN-system in teleost fish.
Fish & shellfish immunology 2007;23(6):1294-303.
2007: Patrick Hanington; Tiehui Wang; Christopher J Secombes; Miodrag Belosevic
Growth factors of lower vertebrates: characterization of goldfish (Carassius auratus L.) macrophage colony-stimulating factor-1.
The Journal of biological chemistry 2007;282(44):31865-72.
2007: Allison C Carrington; Christopher J Secombes
CpG oligodeoxynucleotides up-regulate antibacterial systems and induce protection against bacterial challenge in rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2007;23(4):781-92.
2007: I E Mulder; S Wadsworth; Christopher J Secombes
Cytokine expression in the intestine of rainbow trout (Oncorhynchus mykiss) during infection with Aeromonas salmonicida.
Fish & shellfish immunology 2007;23(4):747-59.
2007: Jun Zou; Carolina Tafalla; Jonathan Truckle; Christopher J Secombes
Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3859-71.
2007: Diana Nascimento; Pedro J B Pereira; Marta I R Reis; Ana do Vale; Jun Zou; Manuel T Silva; Christopher J Secombes; Nuno M S dos Santos
Molecular cloning and expression analysis of sea bass (Dicentrarchus labrax L.) tumor necrosis factor-alpha (TNF-alpha).
Fish & shellfish immunology 2007;23(3):701-10.
2007: Tiehui Wang; Jason W Holland; Allison C Carrington; Jun Zou; Christopher J Secombes
Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-gamma expression in spleen leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1475-88.
2007: Y Corripio-Miyar; C Mazorra de Quero; J W Treasurer; L Ford; P D Smith; Christopher J Secombes
Vaccination experiments in the gadoid haddock, Melanogrammus aeglefinus L., against the bacterial pathogen Vibrio anguillarum.
Veterinary immunology and immunopathology 2007;118(1-2):147-53.
2007: Y Corripio-Miyar; Steve Bird; J W Treasurer; Christopher J Secombes
RAG-1 and IgM genes, markers for early development of the immune system in the gadoid haddock, Melanogrammus aeglefinus, L.
Fish & shellfish immunology 2007;23(1):71-85.
2007: S A M Martin; Bimal P Mohanty; Phillip Cash; Dominic F Houlihan; Christopher J Secombes
Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-gamma stimulation.
Proteomics 2007;7(13):2275-86.
2007: Diana Nascimento; Ana do Vale; Ana M Tomás; Jun Zou; Christopher J Secombes; Nuno M S dos Santos
Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits.
Molecular immunology 2007;44(9):2277-91.
2007: A J A McBeath; Michael Snow; Christopher J Secombes; Anthony E Ellis; Bertrand Collet
Expression kinetics of interferon and interferon-induced genes in Atlantic salmon (Salmo salar) following infection with infectious pancreatic necrosis virus and infectious salmon anaemia virus.
Fish & shellfish immunology 2007;22(3):230-41.
2007: Y Corripio-Miyar; Steve Bird; K Tsamopoulos; Christopher J Secombes
Cloning and expression analysis of two pro-inflammatory cytokines, IL-1 beta and IL-8, in haddock (Melanogrammus aeglefinus).
Molecular immunology 2007;44(6):1361-73.
2007: S A M Martin; Jun Zou; Dominic F Houlihan; Christopher J Secombes
Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling.
BMC genomics 2007;8():150.
2007: Bertrand Collet; Eann S Munro; Suresh Gahlawat; Felix Acosta; Jose Garcia; Christina Roemelt; Jun Zou; Christopher J Secombes; Anthony E Ellis
Infectious pancreatic necrosis virus suppresses type I interferon signalling in rainbow trout gonad cell line but not in Atlantic salmon macrophages.
Fish & shellfish immunology 2007;22(1-2):44-56.
2007: Francisco J Roca; María L Cayuela; Christopher J Secombes; José Meseguer; Victoriano Mulero
Post-transcriptional regulation of cytokine genes in fish: A role for conserved AU-rich elements located in the 3'-untranslated region of their mRNAs.
Molecular immunology 2007;44(4):472-8.
2007: Jun Zou; Claire Mercier; Antonis Koussounadis; Christopher J Secombes
Discovery of multiple beta-defensin like homologues in teleost fish.
Molecular immunology 2007;44(4):638-47.
2007: Cui-Ying Shao; Christopher J Secombes; Andrew J Porter
Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library.
Molecular immunology 2007;44(4):656-65.
2006: Kerry Laing; Jun J Zou; Maureen K Purcell; Ruth Phillips; Christopher J Secombes; John D Hansen
Evolution of the CD4 family: teleost fish possess two divergent forms of CD4 in addition to lymphocyte activation gene-3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3939-51.
2006: Allison C Carrington; Christopher J Secombes
A review of CpGs and their relevance to aquaculture.
Veterinary immunology and immunopathology 2006;112(3-4):87-101.
2006: Stefania Benedetti; Elisa Randelli; Francesco Buonocore; Jun Zou; Christopher J Secombes; Giuseppe Scapigliati
Evolution of cytokine responses: IL-1beta directly affects intracellular Ca2+ concentration of teleost fish leukocytes through a receptor-mediated mechanism.
Cytokine 2006;34(1-2):9-16.
2006: S A M Martin; SC Blaney; Dominic F Houlihan; Christopher J Secombes
Transcriptome response following administration of a live bacterial vaccine in Atlantic salmon (Salmo salar).
Molecular immunology 2006;43(11):1900-11.
2006: Francesco Buonocore; Elisa Randelli; Steve Bird; Christopher J Secombes; Susan Costantini; Angelo M Facchiano; Massimo Mazzini; Giuseppe Scapigliati
The CD8alpha from sea bass (Dicentrarchus labrax L.): Cloning, expression and 3D modelling.
Fish & shellfish immunology 2006;20(4):637-46.
2006: Tomoya Kono; Jun Zou; Steve Bird; Ram Savan; Masahiro Sakai; Christopher J Secombes
Identification and expression analysis of lymphotoxin-beta like homologues in rainbow trout Oncorhynchus mykiss.
Molecular immunology 2006;43(9):1390-401.
2006: A J A McBeath; Bertrand Collet; Richard Paley; Sophie Duraffour; Vidar Aspehaug; Eirik Biering; Christopher J Secombes; Michael Snow
Identification of an interferon antagonist protein encoded by segment 7 of infectious salmon anaemia virus.
Virus research 2006;115(2):176-84.
2006: S Bird; J Zou; Christopher J Secombes
Advances in fish cytokine biology give clues to the evolution of a complex network.
Current pharmaceutical design 2006;12(24):3051-69.
2006: Jennifer I Reddick; Anna Goostrey; Christopher J Secombes
Cloning of iNOS in the small spotted catshark (Scyliorhinus canicula).
Developmental and comparative immunology 2006;30(11):1009-22.
2006: Børre Robertsen; Jun Zou; Christopher J Secombes; Jo-Ann Leong
Molecular and expression analysis of an interferon-gamma-inducible guanylate-binding protein from rainbow trout (Oncorhynchus mykiss).
Developmental and comparative immunology 2006;30(11):1023-33.
2006: Chin-I Chang; Yong-An Zhang; Jun Zou; Pin Nie; Christopher J Secombes
Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and atlantic salmon (Salmo salar).
Antimicrobial agents and chemotherapy 2006;50(1):185-95.
2005: Elgar Susanne Quabius; Guido Krupp; Christopher J Secombes
Polychlorinated biphenyl 126 affects expression of genes involved in stress-immune interaction in primary cultures of rainbow trout anterior kidney cells.
Environmental toxicology and chemistry / SETAC 2005;24(12):3053-60.
2005: Francesco Buonocore; Maria Forlenza; Elisa Randelli; Stefania Benedetti; Paola Bossù; Sabrina Meloni; Christopher J Secombes; Massimo Mazzini; Giuseppe Scapigliati
Biological activity of sea bass (Dicentrarchus labrax L.) recombinant interleukin-1beta.
Marine biotechnology (New York, N.Y.) 2005;7(6):609-17.
2005: Jun Zou; Allison C Carrington; Bertrand Collet; Johannes Martinus Dijkstra; Yasutoshi Yoshiura; Niels Bols; Christopher J Secombes
Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2484-94.
2005: Hani Boshra; Tiehui Wang; Leif Hove-Madsen; John Hansen; Jun Li; Anjun Matlapudi; Christopher J Secombes; Lluis Tort; J Oriol Sunyer
Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2427-37.
2005: Chin-I Chang; Olga Pleguezuelos; Yong-An Zhang; Jun Zou; Christopher J Secombes
Identification of a novel cathelicidin gene in the rainbow trout, Oncorhynchus mykiss.
Infection and immunity 2005;73(8):5053-64.
2005: Christine Stansberg; Sumathi Subramaniam; Bertrand Collet; Christopher J Secombes; Charles Cunningham
Cloning of the Atlantic salmon (Salmo salar) IL-1 receptor associated protein.
Fish & shellfish immunology 2005;19(1):53-65.
2005: Irene S Taylor; Berit Adam; Marie Veverková; Mary F Tatner; Carol Low; Christopher J Secombes; T Harry Birkbeck
T-cell antigen receptor genes in turbot (Scophthalmus maximus L.).
Fish & shellfish immunology 2005;18(5):445-8.
2005: Tiehui Wang; Jason W Holland; Niels Bols; Christopher J Secombes
Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss.
The FEBS journal 2005;272(5):1136-47.
2005: Steve Bird; Jun Zou; Tomoya Kono; Masahiro Sakai; Johannes Martinus Dijkstra; Christopher J Secombes
Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny.
Immunogenetics 2005;56(12):909-23.
2005: Bertrand Collet; Christopher J Secombes
Construction and analysis of a secreting expression vector for fish cells.
Vaccine 2005;23(13):1534-9.
2005: Christopher J Secombes; Steve Bird; Jun Zou
Adaptive immunity in teleosts: cellular immunity.
Developments in biologicals 2005;121():25-32.
2005: Steve Bird; Jun Zou; Ram Savan; Tomoya Kono; Masahiro Sakai; Janet Woo; Christopher J Secombes
Characterisation and expression analysis of an interleukin 6 homologue in the Japanese pufferfish, Fugu rubripes.
Developmental and comparative immunology 2005;29(9):775-89.
2005: Carolina Tafalla; Julio Coll; Christopher J Secombes
Expression of genes related to the early immune response in rainbow trout (Oncorhynchus mykiss) after viral haemorrhagic septicemia virus (VHSV) infection.
Developmental and comparative immunology 2005;29(7):615-26.
2005: Anna Goostrey; Gareth Jones; Christopher J Secombes
Isolation and characterization of CXC receptor genes in a range of elasmobranchs.
Developmental and comparative immunology 2005;29(3):229-42.
2004: Yuko Ota; Eric D Landis; Thomas Boulay; Ruth B Phillips; Bertrand Collet; Christopher J Secombes; Martin F Flajnik; John D Hansen
Homologs of CD83 from elasmobranch and teleost fish.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4553-60.
2004: Yong-An Zhang; Jun Zou; Chin-I Chang; Christopher J Secombes
Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout.
Veterinary immunology and immunopathology 2004;101(3-4):259-69.
2004: Allison C Carrington; Bertrand Collet; Jason W Holland; Christopher J Secombes
CpG oligodeoxynucleotides stimulate immune cell proliferation but not specific antibody production in rainbow trout (Oncorhynchus mykiss).
Veterinary immunology and immunopathology 2004;101(3-4):211-22.
2004: Jun Zou; Yasutoshi Yoshiura; Johannes Martinus Dijkstra; Masahiro Sakai; Mitsuru Ototake; Christopher J Secombes
Identification of an interferon gamma homologue in Fugu, Takifugu rubripes.
Fish & shellfish immunology 2004;17(4):403-9.
2004: I Salinas; K Lockhart; TJ Bowden; Bertrand Collet; Christopher J Secombes; Anthony E Ellis
An assessment of immunostimulants as Mx inducers in Atlantic salmon (Salmo salar L.) parr and the effect of temperature on the kinetics of Mx responses.
Fish & shellfish immunology 2004;17(2):159-70.
2004: Kerry Laing; Christopher J Secombes
Trout CC chemokines: comparison of their sequences and expression patterns.
Molecular immunology 2004;41(8):793-808.
2004: Bertrand Collet; pierre boudinot; Abdenour Benmansour; Christopher J Secombes
An Mx1 promoter-reporter system to study interferon pathways in rainbow trout.
Developmental and comparative immunology 2004;28(7-8):793-801.
2004: Kerry Laing; Christopher J Secombes
Chemokines.
Developmental and comparative immunology 2004;28(5):443-60.
2004: Giuseppe Scapigliati; Susan Costantini; Giovanni Colonna; Angelo M Facchiano; Francesco Buonocore; Paola Bossù; Charles Cunningham; Jason W Holland; Christopher J Secombes
Modelling of fish interleukin-1 and its receptor.
Developmental and comparative immunology 2004;28(5):429-41.
2004: Christopher J Secombes; Charlie Cunningham
Cytokines: an evolutionary perspective.
Developmental and comparative immunology 2004;28(5):373-4.
2004: Jun Zou; Steve Bird; Jonathan Truckle; Niels Bols; Mike Horne; Christopher J Secombes
Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss).
European journal of biochemistry / FEBS 2004;271(10):1913-23.
2004: Suhee Hong; Jun Zou; Bertrand Collet; Niels Bols; Christopher J Secombes
Analysis and characterisation of IL-1beta processing in rainbow trout, Oncorhynchus mykiss.
Fish & shellfish immunology 2004;16(3):453-9.
2004: Tiehui Wang; Niel Johnson; Jun Zou; Niels Bols; Christopher J Secombes
Sequencing and expression of the second allele of the interleukin-1beta1 gene in rainbow trout (Oncorhynchus mykiss): identification of a novel SINE in the third intron.
Fish & shellfish immunology 2004;16(3):335-58.
2004: Audny Johansen; Bertrand Collet; Elin Sandaker; Christopher J Secombes; Jorunn B Jørgensen
Quantification of Atlantic salmon type-I interferon using an Mx1 promoter reporter gene assay.
Fish & shellfish immunology 2004;16(2):173-84.
2004: Thomas Lindenstrøm; Christopher J Secombes; Kurt Buchmann
Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections.
Veterinary immunology and immunopathology 2004;97(3-4):137-48.
2004: Antonis Koussounadis; David W Ritchie; Graham J L Kemp; Christopher J Secombes
Analysis of fish IL-1beta and derived peptide sequences indicates conserved structures with species-specific IL-1 receptor binding: implications for pharmacological design.
Current pharmaceutical design 2004;10(31):3857-71.
2004: Carolina Tafalla; Raquel Aranguren; Christopher J Secombes; Antonio Figueras; Beatriz Novoa
Cloning and analysis of expression of a gilthead sea bream (Sparus aurata) Mx cDNA.
Fish & shellfish immunology 2004;16(1):11-24.
2004: Francesco Buonocore; Massimo Mazzini; Maria Forlenza; Elisa Randelli; Christopher J Secombes; Jun Zou; Giuseppe Scapigliati
Expression in Escherchia coli and purification of sea bass (Dicentrarchus labrax) interleukin 1beta, a possible immunoadjuvant in aquaculture.
Marine biotechnology (New York, N.Y.) 2004;6(1):53-9.
2003: Tiehui Wang; Christopher J Secombes
Complete sequencing and expression of three complement components, C1r, C4 and C1 inhibitor, of the classical activation pathway of the complement system in rainbow trout Oncorhynchus mykiss.
Immunogenetics 2003;55(9):615-28.
2003: Jun Zou; Christopher J Secombes; S Long; N Miller; L William Clem; V Gregory Chinchar
Molecular identification and expression analysis of tumor necrosis factor in channel catfish (Ictalurus punctatus).
Developmental and comparative immunology 2003;27(10):845-58.
2003: Bertrand Collet; Colin McDonald; Christopher J Secombes
The promoter for the Interferon Regulatory Factor (IRF)-2 in the rainbow trout Oncorhynchus mykiss: cloning and reporter gene activity.
Fish & shellfish immunology 2003;15(5):473-7.
2003: Scott Peddie; Pamela E McLauchlan; Anthony E Ellis; Christopher J Secombes
Effect of intraperitoneally administered IL-1beta-derived peptides on resistance to viral haemorrhagic septicaemia in rainbow trout Oncorhynchus mykiss.
Diseases of aquatic organisms 2003;56(3):195-200.
2003: Jun Zou; Scott Peddie; G Scapigliati; Y Zhang; Niels Bols; Anthony E Ellis; Christopher J Secombes
Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss.
Developmental and comparative immunology 2003;27(9):813-22.
2003: Suhee Hong; Scott Peddie; Juan J Campos-Pérez; Jun Zou; Christopher J Secombes
The effect of intraperitoneally administered recombinant IL-1beta on immune parameters and resistance to Aeromonas salmonicida in the rainbow trout (Oncorhynchus mykiss).
Developmental and comparative immunology 2003;27(9):801-12.
2003: Christine Stansberg; Sumathi Subramaniam; Litta Olsen; Christopher J Secombes; Charles Cunningham
Cloning and characterisation of a putative ST2L homologue from Atlantic salmon (Salmo salar).
Fish & shellfish immunology 2003;15(3):211-24.
2003: Jun Zou; Melody S Clark; Christopher J Secombes
Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes.
Immunogenetics 2003;55(5):325-35.
2003: Thomas Lindenstrøm; Kurt Buchmann; Christopher J Secombes
Gyrodactylus derjavini infection elicits IL-1beta expression in rainbow trout skin.
Fish & shellfish immunology 2003;15(2):107-15.
2003: Pamela E McLauchlan; Bertrand Collet; E Ingerslev; Christopher J Secombes; N Lorenzen; Anthony E Ellis
DNA vaccination against viral haemorrhagic septicaemia (VHS) in rainbow trout: size, dose, route of injection and duration of protection-early protection correlates with Mx expression.
Fish & shellfish immunology 2003;15(1):39-50.
2003: Giuseppe Scapigliati; Sabrina Meloni; Francesco Buonocore; Paola Bossù; Daniela Prugnoli; Christopher J Secombes
Immunopurification of B lymphocytes from sea bass Dicentrarchus labrax (L.).
Marine biotechnology (New York, N.Y.) 2003;5(3):214-21.
2003: Carolina Tafalla; Raquel Aranguren; Christopher J Secombes; Jose Luis Castrillo; Beatriz Novoa; Antonio Figueras
Molecular characterisation of sea bream (Sparus aurata) transforming growth factor beta1.
Fish & shellfish immunology 2003;14(5):405-21.
2003: Francesco Buonocore; Daniela Prugnoli; Cinzia Falasca; Christopher J Secombes; Giuseppe Scapigliati
Peculiar gene organisation and incomplete splicing of sea bass (Dicentrarchus labrax L) interleukin-1beta.
Cytokine 2003;21(6):257-64.
2003: Bertrand Collet; Guido C J Hovens; David Mazzoni; Ikuo Hirono; Takashi Aoki; Christopher J Secombes
Cloning and expression analysis of rainbow trout Oncorhynchus mykiss interferon regulatory factor 1 and 2 (IRF-1 and IRF-2).
Developmental and comparative immunology 2003;27(2):111-26.
2003: Jason W Holland; C R W Gould; Catherine S Jones; Leslie R Noble; Christopher J Secombes
The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD).
Parasitology 2003;126 Suppl():S95-102.
2002: Steve Bird; Jun Zou; Tiehui Wang; Barry Munday; Charlie Cunningham; Christopher J Secombes
Evolution of interleukin-1beta.
Cytokine & growth factor reviews 2002;13(6):483-502.
2002: Kerry Laing; Niels Bols; Christopher J Secombes
A CXC chemokine sequence isolated from the rainbow trout Oncorhynchus mykiss resembles the closely related interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11.
European cytokine network 2002;13(4):462-73.
2002: Jason W Holland; T G Pottinger; Christopher J Secombes
Recombinant interleukin-1 beta activates the hypothalamic-pituitary-interrenal axis in rainbow trout, Oncorhynchus mykiss.
The Journal of endocrinology 2002;175(1):261-7.
2002: Catherine S Jones; Anne E Lockyer; Eric Verspoor; Christopher J Secombes; Leslie R Noble
Towards selective breeding of Atlantic salmon for sea louse resistance: approaches to identify trait markers.
Pest management science 2002;58(6):559-68.
2002: Kerry Laing; Jun J Zou; Tiehui Wang; Niels Bols; Ikuo Hirono; Takashi Aoki; Christopher J Secombes
Identification and analysis of an interleukin 8-like molecule in rainbow trout Oncorhynchus mykiss.
Developmental and comparative immunology 2002;26(5):433-44.
2002: Sumathi Subramaniam; Christine Stansberg; Litta Olsen; Jun Zou; Christopher J Secombes; Charles Cunningham
Cloning of a Salmo salar interleukin-1 receptor-like cDNA.
Developmental and comparative immunology 2002;26(5):415-31.
2002: Tiehui Wang; Jun Zou; Charles Cunningham; Christopher J Secombes
Cloning and functional characterisation of the interleukin-1 beta 1 promoter of rainbow trout (Oncorhynchus mykiss).
Biochimica et biophysica acta 2002;1575(1-3):108-16.
2002: Bertrand Collet; Christopher J Secombes
Type I-interferon signalling in fish.
Fish & shellfish immunology 2002;12(5):389-97.
2002: Scott Peddie; Jun Zou; Christopher J Secombes
Immunostimulation in the rainbow trout (Oncorhynchus mykiss) following intraperitoneal administration of Ergosan.
Veterinary immunology and immunopathology 2002;86(1-2):101-13.
2002: Steve Bird; Tiehui Wang; Jun Zou; Charlie Cunningham; Christopher J Secombes
The first cytokine sequence within cartilaginous fish: IL-1 beta in the small spotted catshark (Scyliorhinus canicula).
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3329-40.
2002: Jun Zou; Tiehui Wang; Ikuo Hirono; Takashi Aoki; Hiroyuki Inagawa; T Honda; Gen-Ichiro Soma; Mitsuru Ototake; T Nakanishi; Anthony E Ellis; Christopher J Secombes
Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss.
Developmental and comparative immunology 2002;26(2):161-72.
2002: Giuseppe Scapigliati; Nicla Romano; Francesco Buonocore; Simona Picchietti; MR Baldassini; Daniela Prugnoli; A Galice; Sabrina Meloni; Christopher J Secombes; Massimo Mazzini; luigi abelli
The immune system of sea bass, Dicentrarchus labrax, reared in aquaculture.
Developmental and comparative immunology 2002;26(2):151-60.
2001: Pauline M Cupit; Niels Lorenzen; G Strachan; G J Kemp; Christopher J Secombes; Charles Cunningham
Neutralisation and binding of VHS virus by monovalent antibody fragments.
Virus research 2001;81(1-2):47-56.
2001: Giuseppe Scapigliati; Francesco Buonocore; Steve Bird; Jun Zou; Pablo Pelegrin; C Falasca; Daniela Prugnoli; Christopher J Secombes
Phylogeny of cytokines: molecular cloning and expression analysis of sea bass Dicentrarchus labrax interleukin-1beta.
Fish & shellfish immunology 2001;11(8):711-26.
2001: Scott Peddie; Jun Zou; Charles Cunningham; Christopher J Secombes
Rainbow trout (Oncorhynchus mykiss) recombinant IL-1beta and derived peptides induce migration of head-kidney leucocytes in vitro.
Fish & shellfish immunology 2001;11(8):697-709.
2001: Jorunn B Jørgensen; Jun Zou; Audny Johansen; Christopher J Secombes
Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1beta and interferon-like cytokines in rainbow trout macrophages via a chloroquine-sensitive mechanism.
Fish & shellfish immunology 2001;11(8):673-82.
2001: Christopher J Secombes; Tiehui Wang; Suhee Hong; Scott Peddie; M Crampe; Kerry Laing; Charles Cunningham; Jun Zou
Cytokines and innate immunity of fish.
Developmental and comparative immunology 2001;25(8-9):713-23.
2001: Tiehui Wang; M Ward; Peter Stanislaw Grabowski; Christopher J Secombes
Molecular cloning, gene organization and expression of rainbow trout (Oncorhynchus mykiss) inducible nitric oxide synthase (iNOS) gene.
The Biochemical journal 2001;358(Pt 3):747-55.
2001: Suhee Hong; Jun Zou; M Crampe; Scott Peddie; G Scapigliati; Niels Bols; Charles Cunningham; Christopher J Secombes
The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta.
Veterinary immunology and immunopathology 2001;81(1-2):1-14.
2001: Anne E Lockyer; Catherine S Jones; Leslie R Noble; Eric Verspoor; J Holland; Christopher J Secombes
Isolation and characterisation of a putative interleukin 13 receptor a2 sequence from rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2001;11(6):541-6.
2001: James L Stafford; Pamela E McLauchlan; Christopher J Secombes; Anthony E Ellis; Miodrag Belosevic
Generation of primary monocyte-like cultures from rainbow trout head kidney leukocytes.
Developmental and comparative immunology 2001;25(5-6):447-59.
2001: Kerry Laing; J Holland; S Bonilla; Charles Cunningham; Christopher J Secombes
Cloning and sequencing of caspase 6 in rainbow trout, Oncorhynchus mykiss, and analysis of its expression under conditions known to induce apoptosis.
Developmental and comparative immunology 2001;25(4):303-12.
2001: Tiehui Wang; Christopher J Secombes
Cloning and expression of a putative common cytokine receptor gamma chain (gammaC) gene in rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2001;11(3):233-44.
2001: Bertrand Collet; Christopher J Secombes
The rainbow trout (Oncorhynchus mykiss) Mx1 promoter. Structural and functional characterization.
European journal of biochemistry / FEBS 2001;268(6):1577-84.
2001: Kerry Laing; Tiehui Wang; Jun Zou; J Holland; Suhee Hong; Niels Bols; Ikuo Hirono; Takashi Aoki; Christopher J Secombes
Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumour necrosis factor-alpha.
European journal of biochemistry / FEBS 2001;268(5):1315-22.
2001: Christopher J Secombes; S Bird; Suhee Hong; Kerry Laing; Jun Zou
Phylogeny of vertebrate cytokines.
Advances in experimental medicine and biology 2001;484():89-94.
2000: Niels Lorenzen; Pauline M Cupit; Katja Einer-Jensen; Ellen Lorenzen; Peter Ahrens; Christopher J Secombes; Charles Cunningham
Immunoprophylaxis in fish by injection of mouse antibody genes.
Nature biotechnology 2000;18(11):1177-80.
2000: M A Henry; Christopher J Secombes
The A-layer influences the susceptibility of Aeromonas salmonicida to antibacterial peptides.
Fish & shellfish immunology 2000;10(7):637-42.
2000: Olga Pleguezuelos; Jun Zou; Charles Cunningham; Christopher J Secombes
Cloning, sequencing, and analysis of expression of a second IL-1beta gene in rainbow trout (Oncorhynchus mykiss).
Immunogenetics 2000;51(12):1002-11.
2000: Giuseppe Scapigliati; S Bird; Christopher J Secombes
Invertebrate and fish cytokines.
European cytokine network 2000;11(3):354-61.
2000: Jun Zou; J Holland; Olga Pleguezuelos; Charles Cunningham; Christopher J Secombes
Factors influencing the expression of interleukin-1 beta in cultured rainbow trout (Oncorhynchus mykiss) leucocytes.
Developmental and comparative immunology 2000;24(6-7):575-82.
2000: Giuseppe Scapigliati; Nicla Romano; luigi abelli; Sabrina Meloni; A G Ficca; Francesco Buonocore; Steve Bird; Christopher J Secombes
Immunopurification of T-cells from sea bass Dicentrarchus labrax (L.).
Fish & shellfish immunology 2000;10(4):329-41.
2000: Kerry Laing; Charles Cunningham; Christopher J Secombes
Genes for three different isoforms of transforming growth factor-beta are present in plaice (Pleuronectes platessa) DNA.
Fish & shellfish immunology 2000;10(3):261-71.
2000: Jun Zou; Steve Bird; Ralph Minter; J Horton; Charles Cunningham; Christopher J Secombes
Molecular cloning of the gene for interleukin-1beta from Xenopus laevis and analysis of expression in vivo and in vitro.
Immunogenetics 2000;51(4-5):332-8.
2000: Christopher J Secombes; L Pilström
Evolution of adaptive immunity.
Biologist (London, England) 2000;47(1):44-8.
2000: Niels Lorenzen; Pauline M Cupit; Christopher J Secombes; Charles Cunningham
Three monoclonal antibodies to the VHS virus glycoprotein: comparison of reactivity in relation to differences in immunoglobulin variable domain gene sequences.
Fish & shellfish immunology 2000;10(2):129-42.
2000: J J Campos-Perez; M Ward; Peter Stanislaw Grabowski; Anthony E Ellis; Christopher J Secombes
The gills are an important site of iNOS expression in rainbow trout Oncorhynchus mykiss after challenge with the gram-positive pathogen Renibacterium salmoninarum.
Immunology 2000;99(1):153-61.
1999: Kerry Laing; L Pilström; Charles Cunningham; Christopher J Secombes
TGF-beta3 exists in bony fish.
Veterinary immunology and immunopathology 1999;72(1-2):45-53.
1999: Jun Zou; Peter Stanislaw Grabowski; Charles Cunningham; Christopher J Secombes
Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site.
Cytokine 1999;11(8):552-60.
1999: Jun Zou; Norman F Neumann; Jason W Holland; Miodrag Belosevic; C Cunningham; Christopher J Secombes; Andrew F Rowley
Fish macrophages express a cyclo-oxygenase-2 homologue after activation.
The Biochemical journal 1999;340 ( Pt 1)():153-9.
1999: GD Daniels; Jun Zou; Jacques Charlemagne; S Partula; Charles Cunningham; Christopher J Secombes
Cloning of two chemokine receptor homologs (CXC-R4 and CC-R7) in rainbow trout Oncorhynchus mykiss.
Journal of leukocyte biology 1999;65(5):684-90.
1999: GD Daniels; Christopher J Secombes
Genomic organisation of rainbow trout, Oncorhynchus mykiss TGF-beta.
Developmental and comparative immunology 1999;23(2):139-47.
1999: Jun Zou; Charles Cunningham; Christopher J Secombes
The rainbow trout Oncorhynchus mykiss interleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing.
European journal of biochemistry / FEBS 1999;259(3):901-8.
1999: Kerry Laing; L J Hardie; W Aartsen; Peter Stanislaw Grabowski; Christopher J Secombes
Expression of an inducible nitric oxide synthase gene in rainbow trout Oncorhynchus mykiss.
Developmental and comparative immunology 1999;23(1):71-85.
1998: Christopher J Secombes; Jun Zou; G Daniels; Charles Cunningham; Antonis Koussounadis; G Kemp
Rainbow trout cytokine and cytokine receptor genes.
Immunological reviews 1998;166():333-40.
1998: L J Hardie; Kerry Laing; GD Daniels; Peter Stanislaw Grabowski; Charles Cunningham; Christopher J Secombes
Isolation of the first piscine transforming growth factor beta gene: analysis reveals tissue specific expression and a potential regulatory sequence in rainbow trout (Oncorhynchus mykiss).
Cytokine 1998;10(8):555-63.
1998: M J Marsden; L M Vaughan; R M Fitzpatrick; T J Foster; Christopher J Secombes
Potency testing of a live, genetically attenuated vaccine for salmonids.
Vaccine 1998;16(11-12):1087-94.
1998: S H Hamdani; D N McMillan; E F Pettersen; Heidrun I Wergeland; C Endresen; Anthony E Ellis; Christopher J Secombes
Isolation of rainbow trout neutrophils with an anti-granulocyte monoclonal antibody.
Veterinary immunology and immunopathology 1998;63(4):369-80.
1997: G A Davidson; S H Lin; Christopher J Secombes; A E Ellis
Detection of specific and 'constitutive' antibody secreting cells in the gills, head kidney and peripheral blood leucocytes of dab (Limanda limanda).
Veterinary immunology and immunopathology 1997;58(3-4):363-74.
1997: L A Bowden; G Ed Rainger; Jason W Holland; J Knight; Christopher J Secombes; Andrew F Rowley
Generation and characterisation of monoclonal antibodies against rainbow trout, Oncorhynchus mykiss, leucocytes.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997;117(3):291-8.
1996: E M Riley; S C Young; Christopher J Secombes
Immunisation of rainbow trout Oncorhynchus mykiss with a multiple antigen peptide system (MAPS).
Veterinary immunology and immunopathology 1996;55(1-3):243-53.
1996: M J Marsden; L M Vaughan; T J Foster; Christopher J Secombes
A live (delta aroA) Aeromonas salmonicida vaccine for furunculosis preferentially stimulates T-cell responses relative to B-cell responses in rainbow trout (Oncorhynchus mykiss).
Infection and immunity 1996;64(9):3863-9.
1996: Kerry Laing; Peter Stanislaw Grabowski; Miodrag Belosevic; Christopher J Secombes
A partial sequence for nitric oxide synthase from a goldfish (Carassius auratus) macrophage cell line.
Immunology and cell biology 1996;74(4):374-9.
1996: Beatriz Novoa; Antonio Figueras; Christopher J Secombes
Effects of in vitro addition of infectious pancreatic necrosis virus (IPNV) on rainbow trout Oncorhynchus mykiss leucocyte responses.
Veterinary immunology and immunopathology 1996;51(3-4):365-76.
1996: Beatriz Novoa; Antonio Figueras; I Ashton; Christopher J Secombes
In vitro studies on the regulation of rainbow trout (Oncorhynchus mykiss) macrophage respiratory burst activity.
Developmental and comparative immunology 1996;20(3):207-16.
1996: J Gordon Bell; I Ashton; Christopher J Secombes; B R Weitzel; James R Dick; John R Sargent
Dietary lipid affects phospholipid fatty acid compositions, eicosanoid production and immune function in Atlantic salmon (Salmo salar).
Prostaglandins, leukotrienes, and essential fatty acids 1996;54(3):173-82.
1995: A Tahir; Christopher J Secombes
The effects of diesel oil-based drilling mud extracts on immune responses of rainbow trout.
Archives of environmental contamination and toxicology 1995;29(1):27-32.
1995: S I Jang; L J Hardie; Christopher J Secombes
Elevation of rainbow trout Oncorhynchus mykiss macrophage respiratory burst activity with macrophage-derived supernatants.
Journal of leukocyte biology 1995;57(6):943-7.
1994: I Ashton; K Clements; S E Barrow; Christopher J Secombes; Andrew F Rowley
Effects of dietary fatty acids on eicosanoid-generating capacity, fatty acid composition and chemotactic activity of rainbow trout (Oncorhynchus mykiss) leucocytes.
Biochimica et biophysica acta 1994;1214(3):253-62.
1994: Christopher J Secombes; K Clements; I Ashton; Andrew F Rowley
The effect of eicosanoids on rainbow trout, Oncorhynchus mykiss, leucocyte proliferation.
Veterinary immunology and immunopathology 1994;42(3-4):367-78.
1994: M J Marsden; D Cox; Christopher J Secombes
Antigen-induced release of macrophage activating factor from rainbow trout Oncorhynchus mykiss leucocytes.
Veterinary immunology and immunopathology 1994;42(2):199-208.
1994: L A Bowden; B Weitzel; I P Ashton; Christopher J Secombes; C J Restall; Terence J Walton; Andrew F Rowley
Effect of dietary cholesterol on membrane properties and immune functions in rainbow trout.
Biochemical Society transactions 1994;22(3):339S.
1994: S I Jang; L J Hardie; Christopher J Secombes
Effects of transforming growth factor beta 1 on rainbow trout Oncorhynchus mykiss macrophage respiratory burst activity.
Developmental and comparative immunology 1994;18(4):315-23.
1994: L J Hardie; LH Chappell; Christopher J Secombes
Human tumor necrosis factor alpha influences rainbow trout Oncorhynchus mykiss leucocyte responses.
Veterinary immunology and immunopathology 1994;40(1):73-84.
1994: L J Hardie; T C Fletcher; Christopher J Secombes
Effect of temperature on macrophage activation and the production of macrophage activating factor by rainbow trout (Oncorhynchus mykiss) leucocytes.
Developmental and comparative immunology 1994;18(1):57-66.
1993: G A Davidson; A E Ellis; Christopher J Secombes
Route of immunization influences the generation of antibody secreting cells in the gut of rainbow trout (Oncorhynchus mykiss).
Developmental and comparative immunology 1993;17(4):373-6.
1992: Christopher J Secombes; A R Cross; G J Sharp; R Garcia
NADPH oxidase-like activity in rainbow trout Oncorhynchus mykiss (Walbaum) macrophages.
Developmental and comparative immunology 1992;16(5):405-13.
1992: G J Sharp; Alan Pike; Christopher J Secombes
Sequential development of the immune response in rainbow trout [Oncorhynchus mykiss (Walbaum, 1792)] to experimental plerocercoid infections of Diphyllobothrium dendriticum (Nitzsch, 1824).
Parasitology 1992;104 Pt 1():169-78.
1992: G J Sharp; T R Pettitt; Andrew F Rowley; Christopher J Secombes
Lipoxin-induced migration of fish leukocytes.
Journal of leukocyte biology 1992;51(2):140-5.
1991: S K Whyte; Christopher J Secombes; LH Chappell
Studies on the infectivity of Diplostomum spathaceum in rainbow trout (Oncorhynchus mykiss).
Journal of helminthology 1991;65(3):169-78.
1991: T R Pettitt; Andrew F Rowley; S E Barrow; A I Mallet; Christopher J Secombes
Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss.
The Journal of biological chemistry 1991;266(14):8720-6.
1991: Andrew F Rowley; T R Pettitt; Christopher J Secombes; G J Sharp; S E Barrow; A I Mallet
Generation and biological activities of lipoxins in the rainbow trout--an overview.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21B():557-60.
1991: G J Sharp; Alan Pike; Christopher J Secombes
Leucocyte migration in rainbow trout (Oncorhynchus mykiss [Walbaum]): optimization of migration conditions and responses to host and pathogen (Diphyllobothrium dendriticum [Nitzsch]) derived chemoattractants.
Developmental and comparative immunology 1991;15(4):295-305.
1991: Christopher J Secombes; T C Fletcher; J A O'Flynn; M J Costello; R Stagg; Dominic F Houlihan
Immunocompetence as a measure of the biological effects of sewage sludge pollution in fish.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;100(1-2):133-6.
1990: G J Sharp; Christopher J Secombes; Alan Pike
The laboratory maintenance of Diphyllobothrium dendriticum (Nitzsch, 1824).
Parasitology 1990;101 Pt 1():153-61.
1990: S Graham; Christopher J Secombes
Cellular requirements for lymphokine secretion by rainbow trout Salmo gairdneri leucocytes.
Developmental and comparative immunology 1990;14(1):59-68.
1989: T R Pettitt; Andrew F Rowley; Christopher J Secombes
Lipoxins are major lipoxygenase products of rainbow trout macrophages.
FEBS letters 1989;259(1):168-70.
1988: S Graham; Christopher J Secombes
The production of a macrophage-activating factor from rainbow trout Salmo gairdneri leucocytes.
Immunology 1988;65(2):293-7.
1988: Christopher J Secombes; S Chung; A H Jeffries
Superoxide anion production by rainbow trout macrophages detected by the reduction of ferricytochrome C.
Developmental and comparative immunology 1988;12(1):201-6.
1987: Christopher J Secombes
Lymphokine-release from rainbow trout leucocytes stimulated with concanavalin A. Effects upon macrophage spreading and adherence.
Developmental and comparative immunology 1987;11(3):513-20.
1982: Christopher J Secombes; M J Manning; A E Ellis
Localization of immune complexes and heat-aggregated immunoglobulin in the carp Cyprinus carpio L.
Immunology 1982;47(1):101-5.
1982: Christopher J Secombes; M J Manning; A E Ellis
The effect of primary and secondary immunization on the lymphoid tissues of the carp, Cyprinus carpio L.
The Journal of experimental zoology 1982;220(3):277-87.