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Thomas Seebeck

Research Profile

Concepts & Ideas

Molecular Sequence Data

Chemicals & Drugs

Genes & Molecular Sequences

Disorders

Trypanosomiasis, African

Procedures

Cloning, Molecular

Anatomy

Living Beings

Mouse

Co-author Network

Publications

TOP 3
Lucia Kuhn-Nentwig; Benjamin P Lüscher; Irina M Fedorova; Lukas S Kopp; Wolfgang Nentwig; Johann Schaller; Thomas Seebeck; Erwin Sigel; Kathrin Streitberger; Christian Trachsel; Xuan Lan Vu; Lev G Magazanik
A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities.
Harry P De Koning; Matthew K Gould; Stefan Kunz; Edith Luginbuehl; Geert Jan Sterk; Hermann Tenor; Thomas Seebeck
Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.
Huanchen Wang; Gong Chen; Stefan Kunz; Sibylla Martinelli; Howard Robinson; Thomas Seebeck; Yiqian Wan; Hengming Ke
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.

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All Publications

2012: Lucia Kuhn-Nentwig; Benjamin P Lüscher; Irina M Fedorova; Lukas S Kopp; Wolfgang Nentwig; Johann Schaller; Thomas Seebeck; Erwin Sigel; Kathrin Streitberger; Christian Trachsel; Xuan Lan Vu; Lev G Magazanik
A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities.
The Journal of biological chemistry 2012;287(30):25640-9.
2012: Harry P De Koning; Matthew K Gould; Stefan Kunz; Edith Luginbuehl; Geert Jan Sterk; Hermann Tenor; Thomas Seebeck
Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.
The Journal of infectious diseases 2012;206(2):229-37.
2012: Huanchen Wang; Gong Chen; Stefan Kunz; Sibylla Martinelli; Howard Robinson; Thomas Seebeck; Yiqian Wan; Hengming Ke
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
The Journal of biological chemistry 2012;287(15):11788-97.
2011: Thomas Seebeck; Geert Jan Sterk; Hengming Ke
Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite.
Future medicinal chemistry 2011;3(10):1289-306.
2011: Yasmin Shakur; Harry P de Koning; Junichi Kambayashi; Hengming Ke; Thomas Seebeck
Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases.
Handbook of experimental pharmacology 2011;(204):487-510.
2011: Edith Luginbuehl; Stefan Kunz; Laurent Wentzinger; Florian Freimoser; Thomas Seebeck
The exopolyphosphatase TbrPPX1 of Trypanosoma brucei.
BMC microbiology 2011;11():4.
2011: Lucia Kuhn-Nentwig; Jean Willems; Thomas Seebeck; Tarek Shalaby; Marcel Kaiser; Wolfgang Nentwig
Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells.
Amino acids 2011;40(1):69-76.
2010: Marina Cristodero; Thomas Seebeck; André Schneider
Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei.
Molecular microbiology 2010;78(3):757-69.
2010: Edith Luginbuehl; Damaris Ryter; Judith Schranz-Zumkehr; Michael Oberholzer; Stefan Kunz; Thomas Seebeck
The N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton.
Eukaryotic cell 2010;9(10):1466-75.
2009: Stefan Kunz; Edith Luginbuehl; Thomas Seebeck
Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei.
PLoS neglected tropical diseases 2009;3(6):e455.
2008: Laurent Wentzinger; Selina Elisabeth Ruth Bopp; Hermann Tenor; Juergen Klar; Reto Brun; Hans Peter Beck; Thomas Seebeck
Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein.
International journal for parasitology 2008;38(14):1625-37.
2008: Matthew K Gould; Xuan Lan Vu; Thomas Seebeck; Harry P De Koning
Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay.
Analytical biochemistry 2008;382(2):87-93.
2007: Huanchen Wang; Zier Yan; Jie Geng; Stefan Kunz; Thomas Seebeck; Hengming Ke
Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors.
Molecular microbiology 2007;66(4):1029-38.
2007: Michael Oberholzer; Gabriela Marti; Mario Baresic; Stefan Kunz; Andrew Hemphill; Thomas Seebeck
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(3):720-31.
2007: Michael Oberholzer; Patrick Bregy; Gabriela Marti; Mihaela Minca; Martin Peier; Thomas Seebeck
Trypanosomes and mammalian sperm: one of a kind?
Trends in parasitology 2007;23(2):71-7.
2006: Vincent P Alibu; Christina Richter; Frank Voncken; Gabriela Marti; Sanjay Shahi; Christina Kunz Renggli; Thomas Seebeck; Reto Brun; Christine Clayton
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
Molecular and biochemical parasitology 2006;146(1):38-44.
2006: Andrea Johner; Stefan Kunz; Markus Linder; Yasmin Shakur; Thomas Seebeck
Cyclic nucleotide specific phosphodiesterases of Leishmania major.
BMC microbiology 2006;6():25.
2006: Stefan Kunz; Joseph A Beavo; Maximiliano A D'Angelo; Mirtha M Flawia; Sharron H Francis; Andrea Johner; Sunil Laxman; Michael Oberholzer; Ana Rascon; Yasmin Shakur; Laurent Wentzinger; Roya Zoraghi; Thomas Seebeck
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.
Molecular and biochemical parasitology 2006;145(1):133-5.
2006: Michael Oberholzer; Sabine Morand; Stefan Kunz; Thomas Seebeck
A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes.
Molecular and biochemical parasitology 2006;145(1):117-20.
2005: Stefan Kunz; Michael Oberholzer; Thomas Seebeck
A FYVE-containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi.
The FEBS journal 2005;272(24):6412-22.
2005: Federico Geiser; Alexandra Lüscher; Harry P De Koning; Thomas Seebeck; Pascal Mäser
Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.
Molecular pharmacology 2005;68(3):589-95.
2004: Thomas Seebeck; R Schaub; Andrea Johner
cAMP signalling in the kinetoplastid protozoa.
Current molecular medicine 2004;4(6):585-99.
2004: Stefan Kunz; Thomas Kloeckner; Lars-Oliver Essen; Thomas Seebeck; Michael Boshart
TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei.
European journal of biochemistry / FEBS 2004;271(3):637-47.
2003: Enock Matovu; Mhairi L Stewart; Federico Geiser; Reto Brun; Pascal Mäser; Lynsey J M Wallace; Richard J S Burchmore; John C K Enyaru; Michael P Barrett; Ronald Kaminsky; Thomas Seebeck; Harry P De Koning
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Eukaryotic cell 2003;2(5):1003-8.
2002: Roya Zoraghi; Thomas Seebeck
The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4343-8.
2001: Tarek Shalaby; Matthias Liniger; Thomas Seebeck
The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei.
European journal of biochemistry / FEBS 2001;268(23):6197-206.
2001: Enock Matovu; Federico Geiser; V Schneider; Pascal Mäser; John C K Enyaru; Ronald Kaminsky; Sabina Gallati; Thomas Seebeck
Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy.
Molecular and biochemical parasitology 2001;117(1):73-81.
2001: KW Gong; Stefan Kunz; Roya Zoraghi; Christina Kunz Renggli; Reto Brun; Thomas Seebeck
cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies.
Molecular and biochemical parasitology 2001;116(2):229-32.
2001: Enock Matovu; Thomas Seebeck; John C K Enyaru; Ronald Kaminsky
Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle.
Microbes and infection / Institut Pasteur 2001;3(9):763-70.
2001: Enock Matovu; John C K Enyaru; Dominique Legros; Caecilia Schmid; Thomas Seebeck; Ronald Kaminsky
Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Tropical medicine & international health : TM & IH 2001;6(5):407-11.
2001: Thomas Seebeck; KW Gong; Stefan Kunz; R Schaub; Tarek Shalaby; Roya Zoraghi
cAMP signalling in Trypanosoma brucei.
International journal for parasitology 2001;31(5-6):491-8.
2001: Roya Zoraghi; Stefan Kunz; KW Gong; Thomas Seebeck
Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei.
The Journal of biological chemistry 2001;276(15):11559-66.
2001: C Naula; R Schaub; Vanessa Leech; Sara E Melville; Thomas Seebeck
Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B.
Molecular and biochemical parasitology 2001;112(1):19-28.
2000: I Hunger-Glaser; Andrew Hemphill; Tarek Shalaby; M Hänni; Thomas Seebeck
Nucleoside diphosphate kinase of Trypanosoma brucei.
Gene 2000;257(2):251-7.
2000: C Naula; Thomas Seebeck
Cyclic AMP signaling in trypanosomatids.
Parasitology today (Personal ed.) 2000;16(1):35-8.
1999: Peter Bütikofer; Erik Vassella; S Ruepp; Monika Boschung; G Civenni; Thomas Seebeck; Andrew Hemphill; N Mookherjee; Terry W Pearson; Isabel Roditi
Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane.
Journal of cell science 1999;112 ( Pt 11)():1785-95.
1999: I Hunger-Glaser; Reto Brun; Markus Linder; Thomas Seebeck
Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems.
Molecular and biochemical parasitology 1999;100(1):53-9.
1999: I Hunger-Glaser; Markus Linder; Thomas Seebeck
Histidine-phosphorylation of succinyl CoA synthetase from Trypanosoma brucei.
Molecular and biochemical parasitology 1999;100(1):43-52.
1997: I Hunger-Glaser; Thomas Seebeck
Deletion of the genes for the paraflagellar rod protein PFR-A in Trypanosoma brucei is probably lethal.
Molecular and biochemical parasitology 1997;90(1):347-51.
1997: E Detmer; Andrew Hemphill; N Müller; Thomas Seebeck
The Trypanosoma brucei autoantigen I/6 is an internally repetitive cytoskeletal protein.
European journal of cell biology 1997;72(4):378-84.
1997: W Wilson; Thomas Seebeck
Identification of a profilin homologue in Trypanosoma brucei by complementation screening.
Gene 1997;187(2):201-9.
1996: Norbert Müller; J M Mansfield; Thomas Seebeck
Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts.
Infection and immunity 1996;64(11):4593-7.
1995: Claus Wedekind; Thomas Seebeck; F Bettens; A J Paepke
MHC-dependent mate preferences in humans.
Proceedings. Biological sciences / The Royal Society 1995;260(1359):245-9.
1995: M Imboden; Norbert Müller; Andrew Hemphill; R Mattioli; Thomas Seebeck
Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens.
Parasitology 1995;110 ( Pt 3)():249-58.
1994: J Deflorin; M Rudolf; Thomas Seebeck
The major components of the paraflagellar rod of Trypanosoma brucei are two similar, but distinct proteins which are encoded by two different gene loci.
The Journal of biological chemistry 1994;269(46):28745-51.
1994: M Affolter; Andrew Hemphill; Isabel Roditi; Norbert Müller; Thomas Seebeck
The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei.
Journal of structural biology 1994;112(3):241-51.
1993: Norbert Müller; M Imboden; E Detmer; J M Mansfield; Thomas Seebeck
Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice.
Parasitology 1993;107 ( Pt 4)():411-7.
1993: L Rindisbacher; Andrew Hemphill; Thomas Seebeck
A repetitive protein from Trypanosoma brucei which caps the microtubules at the posterior end of the cytoskeleton.
Molecular and biochemical parasitology 1993;58(1):83-96.
1992: Andrew Hemphill; M Affolter; Thomas Seebeck
A novel microtubule-binding motif identified in a high molecular weight microtubule-associated protein from Trypanosoma brucei.
The Journal of cell biology 1992;117(1):95-103.
1992: Norbert Müller; Andrew Hemphill; M Imboden; Gerard Duvallet; R H Dwinger; Thomas Seebeck
Identification and characterization of two repetitive non-variable antigens from African trypanosomes which are recognized early during infection.
Parasitology 1992;104 Pt 1():111-20.
1991: Andrew Hemphill; Thomas Seebeck; D Lawson
The Trypanosoma brucei cytoskeleton: ultrastructure and localization of microtubule-associated and spectrin-like proteins using quick-freeze, deep-etch, immunogold electron microscopy.
Journal of structural biology 1991;107(3):211-20.
1991: Andrew Hemphill; D Lawson; Thomas Seebeck
The cytoskeletal architecture of Trypanosoma brucei.
The Journal of parasitology 1991;77(4):603-12.
1991: Thomas Seebeck
Molecular biology and parasites.
Experientia 1991;47(2):163-6.
1990: M Vogel; N Müller; Bruno Gottstein; K Flury; Johannes Eckert; Thomas Seebeck
Echinococcus multilocularis: characterization of a DNA probe.
Acta tropica 1990;48(2):109-16.
1989: K Schlaeppi; J Deflorin; Thomas Seebeck
The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes.
The Journal of cell biology 1989;109(4 Pt 1):1695-709.
1989: N Müller; Bruno Gottstein; M Vogel; K Flury; Thomas Seebeck
Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis.
Molecular and biochemical parasitology 1989;36(2):151-9.
1989: K Schlaeppi; Thomas Seebeck
A silent open reading frame of Trypanosoma brucei coding for a protein which shares epitopes with the major structural protein of the paraflagellar rod.
Nucleic acids research 1989;17(13):5399.
1989: V Kueng; K Schlaeppi; A Schneider; Thomas Seebeck
A glycosomal protein (p60) which is predominantly expressed in procyclic Trypanosoma brucei. Characterization and DNA sequence.
The Journal of biological chemistry 1989;264(9):5203-9.
1989: N Müller; M Vogel; Bruno Gottstein; A Scholle; Thomas Seebeck
Plasmid vector for overproduction and export of recombinant protein in Escherichia coli: efficient one-step purification of a recombinant antigen from Echinococcus multilocularis (Cestoda).
Gene 1989;75(2):329-34.
1988: M Vogel; Bruno Gottstein; N Müller; Thomas Seebeck
Production of a recombinant antigen of Echinococcus multilocularis with high immunodiagnostic sensitivity and specificity.
Molecular and biochemical parasitology 1988;31(2):117-25.
1988: A Schneider; Andrew Hemphill; T Wyler; Thomas Seebeck
Large microtubule-associated protein of T. brucei has tandemly repeated, near-identical sequences.
Science (New York, N.Y.) 1988;241(4864):459-62.
1988: A Schneider; H U Lutz; R Marugg; P Gehr; Thomas Seebeck
Spectrin-like proteins in the paraflagellar rod structure of Trypanosoma brucei.
Journal of cell science 1988;90 ( Pt 2)():307-15.
1988: A Schneider; W Eichenberger; Thomas Seebeck
A microtubule-binding protein of Trypanosoma brucei which contains covalently bound fatty acid.
The Journal of biological chemistry 1988;263(14):6472-5.
1988: Thomas Seebeck; V Küng; T Wyler; M Müller
A 60-kDa cytoskeletal protein from Trypanosoma brucei brucei can interact with membranes and with microtubules.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1101-4.
1987: M A Imboden; P W Laird; M Affolter; Thomas Seebeck
Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryote.
Nucleic acids research 1987;15(18):7357-68.
1986: J Stieger; Thomas Seebeck
Monoclonal antibodies against a 60 kDa phenothiazine-binding protein from Trypanosoma brucei can discriminate between different trypanosome species.
Molecular and biochemical parasitology 1986;21(1):37-45.
1986: B Blum; G Pierron; Thomas Seebeck; R Braun
Processing in the external transcribed spacer of ribosomal RNA from Physarum polycephalum.
Nucleic acids research 1986;14(8):3153-66.
1986: M Imboden; B Blum; T DeLange; R Braun; Thomas Seebeck
Tubulin mRNAs of Trypanosoma brucei.
Journal of molecular biology 1986;188(3):393-402.
1984: J Stieger; T Wyler; Thomas Seebeck
Partial purification and characterization of microtubular protein from Trypanosoma brucei.
The Journal of biological chemistry 1984;259(7):4596-602.
1983: B Blum; Thomas Seebeck; R Braun; P Ferris; V Vogt
Localization and DNA sequence around the initiation site of ribosomal RNA transcription in Physarum polycephalum.
Nucleic acids research 1983;11(23):8519-33.
1983: Thomas Seebeck; P Gehr
Trypanocidal action of neuroleptic phenothiazines in Trypanosoma brucei.
Molecular and biochemical parasitology 1983;9(3):197-208.
1983: Thomas Seebeck; P A Whittaker; M A Imboden; N Hardman; R Braun
Tubulin genes of Trypanosoma brucei: a tightly clustered family of alternating genes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(15):4634-8.
1980: U Gubler; T Wyler; Thomas Seebeck; R Braun
Processing of ribosomal precursor RNAs in Physarum polycephalum.
Nucleic acids research 1980;8(12):2647-64.