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Werner Seeger

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Anatomy

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Physiology

Pulmonary Circulation

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Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Moritz Beck-Broichsitter; Tobias Gessler; Regina Reul; Monika Rieger; Werner Seeger; Thomas Schmehl
Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations.
Rio Dumitrascu; Jan Eckermann; Hossein Ardeschir Ghofrani; Jörg Heitmann; Konstantin Mayer; Frank Reichenberger; Werner Seeger; Henning Tiede; Richard Schulz
Sleep apnea in precapillary pulmonary hypertension.

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2013: Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Histology and histopathology 2013;28(6):691-9.
2013: Moritz Beck-Broichsitter; Tobias Gessler; Regina Reul; Monika Rieger; Werner Seeger; Thomas Schmehl
Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2013;84(1):106-14.
2013: Rio Dumitrascu; Jan Eckermann; Hossein Ardeschir Ghofrani; Jörg Heitmann; Konstantin Mayer; Frank Reichenberger; Werner Seeger; Henning Tiede; Richard Schulz
Sleep apnea in precapillary pulmonary hypertension.
Sleep medicine 2013;14(3):247-51.
2013: Soni Pullamsetti; Gamal-Andre Banat; T Braun; Friedrich Grimminger; Jörg Hänze; E Kolosionek; D Pomagruk; Ralph Theo Schermuly; A Schmall; Werner Seeger; M Szibor; Jochen Wilhelm; Rajkumar Savai
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.
Oncogene 2013;32(9):1121-34.
2013: Katrin Högner; Ulrich Kalinke; Peter Lewe-Schlosser; Juergen Lohmeyer; Mikhail Matrosovich; Stephan Pleschka; Stephanie Plog; Werner Seeger; Hans-Dieter Walmrath; Thorsten Wolff; Johannes Bodner; Stefan Gattenlöhner; Achim D Gruber; Susanne Herold
Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.
PLoS pathogens 2013;9(2):e1003188.
2013: Katja Hattar; Dagmar S Lang; Rajkumar Savai; Ralph Theo Schermuly; Anja Schmall; Werner Seeger; Ulf Sibelius; Florentine S B Subtil; Ekkehard Vollmer; Jochen Wilhelm; Gamal-Andre Banat; Gabriele Dahlem; Bastian Eul; Ludger Fink; Torsten Goldmann; Friedrich Grimminger; Ulrich Grandel
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Cancer immunology, immunotherapy : CII 2013;62(2):309-20.
2013: Werner Seeger; Soni S Pullamsetti
Mechanics and mechanisms of pulmonary hypertension-Conference summary and translational perspectives.
Pulmonary circulation 2013;3(1):128-36.
2013: Rio Dumitrascu; Joerg Heitmann; Werner Seeger; Norbert Weissmann; Richard Schulz
Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies.
Oxidative medicine and cellular longevity 2013;2013():234631.
2013: Moritz Beck-Broichsitter; Marie-Christine Knuedeler; Thomas Schmehl; Werner Seeger
Following the concentration of polymeric nanoparticles during nebulization.
Pharmaceutical research 2013;30(1):16-24.
2012: Moritz Beck-Broichsitter; Julia Gauss; Marian Kampschulte; Alexander C Langheinrich; Susanne Roesler; Thomas Schmehl; Christoph Schweiger; Werner Seeger
Micro-computed tomography imaging of composite nanoparticle distribution in the lung.
International journal of pharmaceutics 2012;439(1-2):230-3.
2012: Grazyna Kwapiszewska; Leigh M Marsh; Andrea Olschewski; Sarah L Osswald; Ralph T Schermuly; Werner Seeger; Friederike C Weisel; Norbert Weissmann; Jochen Wilhelm; Malgorzata Wygrecka; Johannes Best; Karolina Chwalek; Bakytbek Egemnazarov; Oliver Eickelberg; Ludger Fink
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
The American journal of pathology 2012;181(6):2018-29.
2012: Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;186(9):897-908.
2012: Yasmin Buchäckert; Nieves M Gabrielli; Benno A Grzesik; Susanne Herold; Konstantin Mayer; Rory Morty; Sebastian Rummel; Werner Seeger; Christine U Vohwinkel; István Vadász
Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs.
The Journal of physiology 2012;590(Pt 20):5167-81.
2012: Michael J Belly; Hossein A Ghofrani; Rory E Morty; Horst Olschewski; Richard Schulz; Werner Seeger; Christian Tanislav; Henning Tiede; Robert Voswinckel; Frank Reichenberger
HbA1c in pulmonary arterial hypertension: a marker of prognostic relevance?
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012;31(10):1109-14.
2012: Moritz Beck-Broichsitter; Thomas Betz; Thomas Kissel; Pia Kleimann; Thomas Schmehl; Udo Bakowsky; Werner Seeger
Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet, ultrasonic, and vibrating-mesh nebulizers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;82(2):272-80.
2012: Anna Bouka; Rio Dumitrascu; Cornelia Hecker; Linda Liebich; Konstantin Mayer; Frank Reichenberger; Werner Seeger; Henning Tiede; Richard Schulz
Quality of life in clinically stable adult cystic fibrosis out-patients: associations with daytime sleepiness and sleep quality.
Respiratory medicine 2012;106(9):1244-9.
2012: Prakash Chelladurai; Werner Seeger; Soni Pullamsetti
Matrix metalloproteinases and their inhibitors in pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(3):766-82.
2012: Nefertiti El-Nikhely; Leyre Larzabal; Alfonso Calvo; Werner Seeger; Rajkumar Savai
Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention.
Expert opinion on investigational drugs 2012;21(8):1107-22.
2012: Soni Pullamsetti; Stephan Rosenkranz; Rajkumar Savai; Werner Seeger; Aleksandra Tretyn; Norbert Weissmann; Eva Maria Berghausen; Ralf P Brandes; Elsa Butrous; Ghazwan Butrous; Swati Dabral; Bhola Kumar Dahal; Hossein A Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1354-65.
2012: Konstantin Mayer; Werner Seeger
[Pneumological intensive care medicine].
Der Internist 2012;53(5):533.
2012: Grazyna Kwapiszewska; Philipp Markart; Leigh Matthew Marsh; Andreas Meinhardt; Andrea Olschewski; Klaus Theo Preissner; Ralph Theo Schermuly; Werner Seeger; Martin Steinhoff; Christian Taube; Norbert Weissmann; Bhola Kumar Dahal; Hossein A Ghofrani; Baktybek Kojonazarov; Malgorzata Wygrecka
PAR-2 inhibition reverses experimental pulmonary hypertension.
Circulation research 2012;110(9):1179-91.
2012: Manish Mittal; Oleg Pak; Matthew E Pamenter; Ralph Theo Schermuly; Werner Seeger; Ralf P Brandes; D Beate Fuchs; H A Ghofrani; Friedrich Grimminger; Xiang Q Gu; Daniela Haag; Gabriel G Haddad; Norbert Weissmann
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
Free radical biology & medicine 2012;52(6):1033-42.
2012: Moritz Beck-Broichsitter; Tobias Gessler; Thomas Schmehl; Christoph Schweiger; Werner Seeger; Thomas Kissel
Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2012;158(2):329-35.
2012: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Andreas M Zeiher; Angelika Bonauer; Bhola K Dahal; Stefanie Dimmeler; Carmen Doebele; Ariane Fischer; Hossein A Ghofrani; Friedrich Grimminger; Baktybek Kojonazarov; Ralph Theo Schermuly
Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2012;185(4):409-19.
2012: Moritz Beck-Broichsitter; Tobias Gessler; Thomas Schmehl; Werner Seeger; Thomas Kissel
Development of a biodegradable nanoparticle platform for sildenafil: formulation optimization by factorial design analysis combined with application of charge-modified branched polyesters.
Journal of controlled release : official journal of the Controlled Release Society 2012;157(3):469-77.
2012: István Vadász; Lynn C Welch; Greg J Beitel; Arturo Briva; G R Scott Budinger; Laura A Dada; Yosef Gruenbaum; Benno A Grzesik; Iiro Taneli Helenius; Aileen M Kelly; Jing Liu; Werner Seeger; Kfir Sharabi; Jacob I Sznajder
Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.
PloS one 2012;7(10):e46696.
2012: Michaela Lang; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Anuar Kalymbetov; Baktybek Kojonazarov; Axel Kretschmer; Werner Seeger; Johannes-Peter Stasch; Xia Tian; Norbert Weissmann; Ralph Theo Schermuly
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
PloS one 2012;7(8):e43433.
2012: Norbert Weissmann; Michael Mederos y Schnitzler; Ralf P Brandes; Alison C Brewer; Marc Freichel; Beate Fuchs; Hossein A Ghofrani; Friedrich Grimminger; Thomas Gudermann; Hermann Kalwa; Karl-Heinz Krause; Marcel Meissner; Stefan Offermanns; Oleg Pak; Ralph Theo Schermuly; Harald H H W Schmidt; Werner Seeger; Ajay M Shah; Ursula Storch; Akylbek Sydykov; Florian Veit; Alexander Dietrich
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Nature communications 2012;3():649.
2012: Farzaneh Ketabchi; Ralph T Schermuly; Werner Seeger; S Mostafa Shid-Moosavi; Gholam A Dehghani; Bakytbek Egemnazarov; Hossein A Ghofrani; Friedrich Grimminger; Norbert Weissmann; Natascha Sommer
Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.
Respiratory research 2012;13():7.
2011: Michael Seimetz; Akylbek Sydykov; Agnieszka Turowska; Florian Veit; Robert Voswinckel; Friederike C Weisel; Rio Dumitrascu; Bakytbek Egemnazarov; Beate Fuchs; Holger Garn; Hossein A Ghofrani; Friedrich Grimminger; Peter Jaksch; Walter Klepetko; Sawa Kostin; Grazyna Kwapiszewska; Thomas Medebach; Katrin Milger; Sandeep Nikam; Nirmal Parajuli; Alexandra Pichl; Markus Roth; Ralph T Schermuly; Werner Seeger; Norbert Weissmann
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
Cell 2011;147(2):293-305.
2011: Sibel Avcuoglu; Ludger Fink; Andreas Günther; Leigh M Marsh; Rory Morty; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Grazyna Kwapiszewska
Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2011;45(4):768-80.
2011: Vandana S Nikam; Ulf Rapp; Ralph Schermuly; Werner Seeger; Kirsten Szelepusa; Gesa Wecker; Robert Voswinckel
Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase.
American journal of respiratory cell and molecular biology 2011;45(4):692-703.
2011: Malgorzata Wygrecka; Dariusz Zakrzewicz; Andreas Guenther; Ewa Jablonska; Klaus T Preissner; Werner Seeger; Jochen Wilhelm; Philipp Markart
Shedding of low-density lipoprotein receptor–related protein-1 in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2011;184(4):438-48.
2011: Florentine Kamlah; Michael Scholz; Ulrike Seay; Werner Seeger; Gisela Taucher-Scholz; Andrea Arenz; Birgit Bischoff; Rita Engenhart-Cabillic; Claudia Fournier; Oana R Gottschald; Jörg Hänze; Diya Hasan; Janko Juricko; Frank Rose
Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells.
International journal of radiation oncology, biology, physics 2011;80(5):1541-9.
2011: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Dariusz Zakrzewicz; Bhola Kumar Dahal; Rio Dumitrascu; Oliver Eickelberg; Hossein A Ghofrani; Friedrich Grimminger; Andreas Guenther; Melanie Konigshoff; James Leiper; Ralph Theo Schermuly
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Science translational medicine 2011;3(87):87ra53.
2011: Tobias Gessler; Werner Seeger; Thomas Schmehl
The potential for inhaled treprostinil in the treatment of pulmonary arterial hypertension.
Therapeutic advances in respiratory disease 2011;5(3):195-206.
2011: Moritz Beck-Broichsitter; Clemens Ruppert; Thomas Schmehl; Andreas Guenther; Thomas Betz; Udo Bakowsky; Werner Seeger; Thomas Kissel; Tobias Gessler
Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro.
Nanomedicine : nanotechnology, biology, and medicine 2011;7(3):341-50.
2011: Susanne Herold; Katrin Hoegner; Hermann Janssen; Peter Lewe-Schlosser; Werner Seeger; Mirko Steinmueller; Tannaz Shafiei Tabar; Istvan Vadasz; Jens Albrecht; Maciej Cabanski; Frank Driever; Jürgen Lohmeyer
Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.
American journal of respiratory and critical care medicine 2011;183(10):1380-90.
2011: Martina Korfei; Günter Lochnit; Benjamin Loeh; Poornima Mahavadi; Philipp Markart; Klaus T Preissner; Clemens Ruppert; Liliana Schaefer; Sigrid Schmitt; Werner Seeger; Malgorzata Wygrecka; Philippe Bonniaud; Ludger Fink; Ingrid Henneke; Walter Klepetko; Andreas Guenther
Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs.
Journal of proteome research 2011;10(5):2185-205.
2011: R Dumitrascu; C Kulcke; M Königshoff; F Kouri; X Yang; N Morrell; Hossein A Ghofrani; Norbert Weissmann; R Reiter; Werner Seeger; Friedrich Grimminger; O Eickelberg; Ralph Theo Schermuly; S S Pullamsetti
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(5):1104-18.
2011: Bhola K Dahal; Hossein A Ghofrani; Friedrich Grimminger; Rainer Heuchel; Soni Pullamsetti; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Ralph Theo Schermuly
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.
Pulmonary circulation 2011;1(2):259-68.
2011: Melanie Thamm; Henning Tiede; Robert Voswinckel; Friedrich Grimminger; Friederike Lendeckel; Werner Seeger; Hossein A Ghofrani
Air travel can be safe and well tolerated in patients with clinically stable pulmonary hypertension.
Pulmonary circulation 2011;1(2):239-43.
2011: Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation 2011;123(11):1194-204.
2011: Susanne Roesler; Felix P V Koch; Thomas Schmehl; Norbert Weissmann; Werner Seeger; Tobias Gessler; Thomas Kissel
Amphiphilic, low molecular weight poly(ethylene imine) derivatives with enhanced stability for efficient pulmonary gene delivery.
The journal of gene medicine 2011;13(2):123-33.
2011: Djuro Kosanovic; Himal Luitel; Werner Seeger; Akylbek Sydykov; Norbert Weissmann; Ralf P Brandes; Teodora Cornitescu; Bhola K Dahal; Neil Davie; Hossein A Ghofrani; Friedrich Grimminger; Wiebke Janssen; Baktybek Kojonazarov; Ralph Theo Schermuly
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Respiratory research 2011;12():87.
2011: Bhola K Dahal; Djuro Kosanovic; Christina Kaulen; Teodora Cornitescu; Rajkumar Savai; Julia Hoffmann; Irwin Reiss; Hossein A Ghofrani; Norbert Weissmann; Wolfgang M Kuebler; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Respiratory research 2011;12():60.
2011: Piotr Sklepkiewicz; Ralph Theo Schermuly; Xia Tian; Hossein Ardeschir Ghofrani; Norbert Weissmann; Daniel Sedding; Tarek Kashour; Werner Seeger; Friedrich Grimminger; Soni Savai Pullamsetti
Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.
PloS one 2011;6(4):e18883.
2011: Xia Tian; Christina Vroom; Hossein Ardeschir Ghofrani; Norbert Weissmann; Ewa Bieniek; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Soni Savai Pullamsetti
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
PloS one 2011;6(4):e18136.
2011: Beate Fuchs; Markus Rupp; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Thomas Gudermann; Alexander Dietrich; Norbert Weissmann
Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
Respiratory research 2011;12():20.
2011: S S Pullamsetti; Rajkumar Savai; W Janssen; B K Dahal; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly
Inflammation, immunological reaction and role of infection in pulmonary hypertension.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(1):7-14.
2011: Mike Althaus; Alexandra Pichl; Wolfgang Clauss; Werner Seeger; Martin Fronius; Rory Morty
Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells.
American journal of respiratory cell and molecular biology 2011;44(1):53-65.
2010: Beate Fuchs; Natascha Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Thomas Gudermann; Norbert Weissmann
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction.
Respiratory physiology & neurobiology 2010;174(3):282-91.
2010: Moritz Beck-Broichsitter; Marcel Thieme; Juliane Nguyen; Thomas Schmehl; Tobias Gessler; Werner Seeger; Seema Agarwal; Andreas Greiner; Thomas Kissel
Novel 'nano in nano' composites for sustained drug delivery: biodegradable nanoparticles encapsulated into nanofiber non-wovens.
Macromolecular bioscience 2010;10(12):1527-35.
2010: Oana R Gottschald; Viktor Malec; Gabriela Krasteva; Diya Hasan; Florentine Kamlah; Susanne Herold; Frank Rose; Werner Seeger; Jörg Hänze
TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.
Journal of molecular cell biology 2010;2(6):345-56.
2010: Juliane Nguyen; Regina Reul; Susanne Roesler; Eyas Dayyoub; Thomas Schmehl; Tobias Gessler; Werner Seeger; Thomas H Kissel
Amine-modified poly(vinyl alcohol)s as non-viral vectors for siRNA delivery: effects of the degree of amine substitution on physicochemical properties and knockdown efficiency.
Pharmaceutical research 2010;27(12):2670-82.
2010: V S Nikam; Ralph Theo Schermuly; R Dumitrascu; Norbert Weissmann; G Kwapiszewska; N Morrell; W Klepetko; L Fink; Werner Seeger; Robert Voswinckel
Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(6):1302-14.
2010: Melanie Königshoff; Rio Dumitrascu; Sergey Udalov; Oana Veronica Amarie; Rudolf Reiter; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention.
Thorax 2010;65(11):949-55.
2010: N Sommer; O Pak; S Schörner; T Derfuss; A Krug; E Gnaiger; Hossein A Ghofrani; Ralph Theo Schermuly; C Huckstorf; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1056-66.
2010: Ladislau Kiss; Hartwig Schütte; Winfried Padberg; Norbert Weissmann; Konstantin Mayer; Tobias Gessler; Robert Voswinckel; Werner Seeger; Friedrich Grimminger
Epoxyeicosatrienoates are the dominant eicosanoids in human lungs upon microbial challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1088-98.
2010: Karsten grosse Kreymborg; Shizuka Uchida; Pascal Gellert; André Schneider; Thomas Boettger; Robert Voswinckel; Astrid Wietelmann; Marten Szibor; Norbert Weissmann; Ardeschir Hossein Ghofrani; Ralph Schermuly; Dietmar Schranz; Werner Seeger; Thomas Braun
Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.
Journal of molecular and cellular cardiology 2010;49(4):598-605.
2010: B K Dahal; D Kosanovic; P K Pamarthi; A Sydykov; Y-J Lai; R Kast; H Schirok; J-P Stasch; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):808-18.
2010: Matthias Hecker; Zbigniew Zaslona; Grazyna Kwapiszewska; Gero Niess; Anna Zakrzewicz; Eduard Hergenreider; Jochen Wilhelm; Leigh M Marsh; Daniel G Sedding; Walter Klepetko; Jürgen Lohmeyer; Stefanie Dimmeler; Werner Seeger; Norbert Weissmann; Ralph Theo Schermuly; Nikolaus Kneidinger; Oliver Eickelberg; Rory Morty
Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2010;182(6):805-18.
2010: Hans Joachim Eisele; Frank Reichenberger; Konstantin Mayer; Norbert Weissmann; Werner Seeger; Richard Schulz
Obstructive sleep apnea in a patient with the Melkersson-Rosenthal syndrome.
Sleep & breathing = Schlaf & Atmung 2010;14(3):245-7.
2010: Poornima Mahavadi; Martina Korfei; Ingrid Henneke; Gerhard Liebisch; Gerd Schmitz; Bernadette R Gochuico; Philipp Markart; Saverio Bellusci; Werner Seeger; Clemens Ruppert; Andreas Guenther
Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.
American journal of respiratory and critical care medicine 2010;182(2):207-19.
2010: Katja Hattar; S Oppermann; C Ankele; Norbert Weissmann; Ralph Theo Schermuly; Rainer M Bohle; R Moritz; B Krögel; Werner Seeger; Friedrich Grimminger; Ulf Sibelius; Ulrich Grandel
c-ANCA-induced neutrophil-mediated lung injury: a model of acute Wegener's granulomatosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(1):187-95.
2010: Viktor Malec; Oana R Gottschald; Shu Li; Frank Rose; Werner Seeger; Jörg Hänze
HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells.
Free radical biology & medicine 2010;48(12):1626-35.
2010: Philipp Markart; Robert Nass; Clemens Ruppert; Lukas Hundack; Malgorzata Wygrecka; Martina Korfei; Rolf H Boedeker; Gerd Staehler; Hartmut Kroll; Gerhard Scheuch; Werner Seeger; Andreas Guenther
Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis.
Journal of aerosol medicine and pulmonary drug delivery 2010;23(3):161-72.
2010: Vallerie V McLaughlin; Raymond L Benza; Lewis J Rubin; Richard N Channick; Robert Voswinckel; Victor F Tapson; Ivan M Robbins; Horst Olschewski; Melvyn Rubenfire; Werner Seeger
Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial.
Journal of the American College of Cardiology 2010;55(18):1915-22.
2010: Horst Olschewski; Marius M Hoeper; Jürgen Behr; Ralf Ewert; Andreas Meyer; Mathias M Borst; Jörg Winkler; Michael Pfeifer; Heinrike Wilkens; Hossein A Ghofrani; Sylvia Nikkho; Werner Seeger
Long-term therapy with inhaled iloprost in patients with pulmonary hypertension.
Respiratory medicine 2010;104(5):731-40.
2010: Ingrid Henneke; Susanne Greschus; Rajkumar Savai; Martina Korfei; Philipp Markart; Poornima Mahavadi; Ralph Theo Schermuly; Malgorzata Wygrecka; Jörg Stürzebecher; Werner Seeger; Andreas Günther; Clemens Ruppert
Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.
American journal of respiratory and critical care medicine 2010;181(6):611-9.
2010: Hossein-Ardeschir Ghofrani; Robert Voswinckel; Henning Gall; Ralph Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Riociguat for pulmonary hypertension.
Future cardiology 2010;6(2):155-66.
2010: J-C Wolff; J Wilhelm; L Fink; Werner Seeger; Robert Voswinckel
Comparative gene expression profiling of post-natal and post-pneumonectomy lung growth.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(3):655-66.
2010: Moritz Beck-Broichsitter; Julia Gauss; Tobias Gessler; Werner Seeger; Thomas Kissel; Thomas Schmehl
Pulmonary targeting with biodegradable salbutamol-loaded nanoparticles.
Journal of aerosol medicine and pulmonary drug delivery 2010;23(1):47-57.
2010: Ming Hua Bi; Juliane Ott; Tobias Fischer; Matthias Hecker; Hartmut Dietrich; Martina Barbara Schaefer; Philipp Markart; Bao En Wang; Werner Seeger; Konstantin Mayer
Induction of lymphocyte apoptosis in a murine model of acute lung injury--modulation by lipid emulsions.
Shock (Augusta, Ga.) 2010;33(2):179-88.
2010: Bhola Kumar Dahal; Teodora Cornitescu; Aleksandra Tretyn; Soni Savai Pullamsetti; Djuro Kosanovic; Rio Dumitrascu; Hossein A Ghofrani; Norbert Weissmann; Robert Voswinckel; Gamal-Andre Banat; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2010;181(2):158-67.
2010: Sevdalina Nikolova; Andreas Guenther; Rajkumar Savai; Norbert Weissmann; Hossein A Ghofrani; Melanie Konigshoff; Oliver Eickelberg; Walter Klepetko; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly; Soni Pullamsetti
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Respiratory research 2010;11():146.
2010: Bakytbek Egemnazarov; Ralph Theo Schermuly; Bhola K Dahal; Garry T Elliott; Niel C Hoglen; Mark W Surber; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.
Respiratory research 2010;11():81.
2010: Sergey Udalov; Rio Dumitrascu; Soni Pullamsetti; Hamza M Al-tamari; Norbert Weissmann; Hossein A Ghofrani; Andreas Guenther; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.
BMC pulmonary medicine 2010;10():26.
2010: Konstantin Mayer; Werner Seeger
Fish oil-containing lipid emulsions in patients with sepsis.
Critical care (London, England) 2010;14(2):128.
2009: Arun Kumarasamy; Isabelle Schmitt; Alexander H Nave; Irwin Reiss; Irene van der Horst; Eva Dony; Jesse D Roberts; Ronald R de Krijger; Dick Tibboel; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg; Rory Morty
Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs.
American journal of respiratory and critical care medicine 2009;180(12):1239-52.
2009: Mike Althaus; Martin Fronius; Yasmin Buchäckert; István Vadász; Wolfgang Clauss; Werner Seeger; Roberto Motterlini; Rory Morty
Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels.
American journal of respiratory cell and molecular biology 2009;41(6):639-50.
2009: Juliane Nguyen; Regina Reul; Thomas Betz; Eyas Dayyoub; Thomas Schmehl; Tobias Gessler; Udo Bakowsky; Werner Seeger; Thomas Kissel
Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(1):47-54.
2009: Ewa Kolosionek; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Andreas Guenther; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat; Ralph Theo Schermuly; Soni Pullamsetti
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
Molecular biology of the cell 2009;20(22):4751-65.
2009: Frank Reichenberger; Robert Voswinckel; R Schulz; O Mensch; Hossein A Ghofrani; H Olschewski; Werner Seeger
Noninvasive detection of early pulmonary vascular dysfunction in scleroderma.
Respiratory medicine 2009;103(11):1713-8.
2009: Ulrich Grandel; Diana Heygster; Ulf Sibelius; Ludger Fink; Stefanie Sigel; Werner Seeger; Friedrich Grimminger; Katja Hattar
Amplification of lipopolysaccharide-induced cytokine synthesis in non-small cell lung cancer/neutrophil cocultures.
Molecular cancer research : MCR 2009;7(10):1729-35.
2009: Norbert Weissmann; Sascha Hackemack; Bhola Kumar Dahal; Soni Savai Pullamsetti; Rajkumar Savai; Manish Mittal; Beate Fuchs; Thomas Medebach; Rio Dumitrascu; Martin van Eickels; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L658-65.
2009: Lidija Cakarova; Leigh M Marsh; Jochen Wilhelm; Konstantin Mayer; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer; Susanne Herold
Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
American journal of respiratory and critical care medicine 2009;180(6):521-32.
2009: Robert Voswinckel; Frank Reichenberger; H Gall; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[Therapy of pulmonary arterial hypertension].
Der Internist 2009;50(9):1101-2, 1104-9.
2009: Martin Roderfeld; Timo Rath; Richard Schulz; Werner Seeger; Annette Tschuschner; Jürgen Graf; Elke Roeb
Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2009;8(5):338-47.
2009: Elke Kleemann; Norman Jekel; Lea Ann Dailey; Susanne Roesler; Ludger Fink; Norbert Weissmann; Ralph Schermuly; Tobias Gessler; Thomas Schmehl; Clive J Roberts; Werner Seeger; Thomas Kissel
Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery.
Journal of drug targeting 2009;17(8):638-51.
2009: Markus Roth; Markus Rupp; Simone Hofmann; Manish Mittal; Beate Fuchs; Natascha Sommer; Nirmal Parajuli; Karin Quanz; Dominic Schubert; Eva Dony; Ralph Theo Schermuly; Hossein A Ghofrani; Ulrike Sausbier; Katrin Rutschmann; Sarah Wilhelm; Werner Seeger; Peter Ruth; Friedrich Grimminger; Matthias Sausbier; Norbert Weissmann
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
American journal of respiratory and critical care medicine 2009;180(4):353-64.
2009: Vallerie V McLaughlin; David B Badesch; Marion Delcroix; Thomas R Fleming; Sean Gaine; Nazzareno Galiè; J Simon R Gibbs; Nick H Kim; Ronald J Oudiz; Andrew Peacock; Steeve Provencher; Olivier Sitbon; Victor F Tapson; Werner Seeger
End points and clinical trial design in pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S97-107.
2009: Isabel P Laumanns; Ludger Fink; Jochen Wilhelm; Jens-C Wolff; Rita Mitnacht-Kraus; Sabine Graef-Hoechst; Maria M Stein; Rainer M Bohle; Walter Klepetko; Mir A R Hoda; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger; Robert Voswinckel
The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.
American journal of respiratory cell and molecular biology 2009;40(6):683-91.
2009: Melanie Königshoff; Monika Kramer; Nisha Balsara; Jochen Wilhelm; Oana Veronica Amarie; Andreas Jahn; Frank Rose; Ludger Fink; Werner Seeger; Liliana Schaefer; Andreas Günther; Oliver Eickelberg
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis.
The Journal of clinical investigation 2009;119(4):772-87.
2009: K Woyda; S Koebrich; Irwin Reiss; Silvia Rudloff; Soni Pullamsetti; A Rühlmann; Norbert Weissmann; Hossein A Ghofrani; Andreas Günther; Werner Seeger; Friedrich Grimminger; Rory Morty; Ralph Theo Schermuly
Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):861-70.
2009: Konstantin Mayer; Almuth Kiessling; Juliane Ott; Martina Barbara Schaefer; Matthias Hecker; Ingrid Henneke; Richard Schulz; Andreas Günther; Jingdong Wang; Lijun Wu; Joachim Roth; Werner Seeger; Jing X Kang
Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids.
American journal of respiratory and critical care medicine 2009;179(6):474-83.
2009: Frank Reichenberger; Werner Seeger; S Nitschmann
[Therapy of mild, but symptomatic pulmonary hypertension].
Der Internist 2009;50(3):374-6.
2009: Leigh M Marsh; Lidija Cakarova; Grazyna Kwapiszewska; Werner von Wulffen; Susanne Herold; Werner Seeger; Jürgen Lohmeyer
Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L442-52.
2009: Bakytbek Egemnazarov; Akylbek Sydykov; Ralph Theo Schermuly; Norbert Weissmann; Johannes-Peter Stasch; Akpai S Sarybaev; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L462-9.
2009: F Kamlah; Bastian Eul; S Li; N Lang; Leigh M Marsh; Werner Seeger; Friedrich Grimminger; Frank Rose; Jörg Hänze
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.
Cancer gene therapy 2009;16(3):195-205.
2009: Moritz Beck-Broichsitter; Julia Gauss; Claudia B Packhaeuser; Kerstin Lahnstein; Thomas Schmehl; Werner Seeger; Thomas Kissel; Tobias Gessler
Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model.
International journal of pharmaceutics 2009;367(1-2):169-78.
2009: Robert Voswinckel; Frank Reichenberger; Henning Gall; Thomas Schmehl; Tobias Gessler; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Hossein A Ghofrani; Horst Olschewski
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2009;22(1):50-6.
2009: Philipp Markart; Thomas Luboeinski; Martina Korfei; Reinhold Schmidt; Malgorzata Wygrecka; Poornima Mahavadi; Konstantin Mayer; Jochen Wilhelm; Werner Seeger; Andreas Guenther; Clemens Ruppert
Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases.
Antioxidants & redox signaling 2009;11(2):227-40.
2009: Zbigniew Zasłona; Jochen Wilhelm; Lidija Cakarova; Leigh M Marsh; Werner Seeger; Jürgen Lohmeyer; Werner von Wulffen
Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking.
Respiratory research 2009;10():2.
2008: Clemens Ruppert; Poornima Mahavadi; Malgorzata Wygrecka; Timothy E Weaver; Viktor Magdolen; Steven Idell; Klaus T Preissner; Werner Seeger; Andreas Günther; Philipp Markart
Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase.
Thrombosis and haemostasis 2008;100(6):1185-92.
2008: N Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein A Ghofrani; Thomas Gudermann; Rainer Schulz; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(6):1639-51.
2008: Martina Barbara Schaefer; A Pose; J Ott; Matthias Hecker; A Behnk; Richard Schulz; Norbert Weissmann; Andreas Günther; Werner Seeger; Konstantin Mayer
Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(5):1344-53.
2008: Martina Korfei; Clemens Ruppert; Poornima Mahavadi; Ingrid Henneke; Philipp Markart; Miriam Koch; Gyoergy Lang; Ludger Fink; Rainer-Maria Bohle; Werner Seeger; Timothy E Weaver; Andreas Guenther
Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2008;178(8):838-46.
2008: Ladislau Kiss; Jens Bier; Yasmin Röder; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection.
Analytical and bioanalytical chemistry 2008;392(4):717-26.
2008: Robert Voswinckel; Frank Reichenberger; Beate Enke; Andre Kreckel; Stefanie Krick; Henning Gall; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Horst Olschewski; Werner Seeger; Hossein A Ghofrani
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2008;21(5):824-32.
2008: Shu Li; Sarvenaz Shafiei Tabar; Viktor Malec; Bastian G Eul; Walter Klepetko; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Frank Rose; Jörg Hänze
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.
Antioxidants & redox signaling 2008;10(10):1687-98.
2008: J Sevilla-Pérez; Melanie Königshoff; Grazyna Kwapiszewska; Oana V Amarie; Werner Seeger; Norbert Weissmann; Ralph Theo Schermuly; Rory Morty; Oliver Eickelberg
Shroom expression is attenuated in pulmonary arterial hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):871-80.
2008: Ralph Theo Schermuly; J-P Stasch; Soni Pullamsetti; Ralf Middendorff; D Müller; Klaus-Dieter Schlüter; A Dingendorf; S Hackemack; E Kolosionek; C Kaulen; Rio Dumitrascu; Norbert Weissmann; J Mittendorf; Walter Klepetko; Werner Seeger; Hossein A Ghofrani; Friedrich Grimminger
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):881-91.
2008: Grazyna Kwapiszewska; Malgorzata Wygrecka; Leigh M Marsh; Sigrid Schmitt; Roger Trösser; Jochen Wilhelm; Katja Helmus; Bastian Eul; Anna Zakrzewicz; Hossein A Ghofrani; Ralph Theo Schermuly; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Oliver Eickelberg; Ludger Fink; Norbert Weissmann
Fhl-1, a new key protein in pulmonary hypertension.
Circulation 2008;118(11):1183-94.
2008: Stefanie Lis; Stephan Krieger; Dorothee Hennig; Christian Röder; Peter Kirsch; Werner Seeger; Bernd Gallhofer; Richard Schulz
Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea.
Journal of sleep research 2008;17(3):271-80.
2008: Katrin Ahlbrecht; Judith Schmitz; Ulrike Seay; Christine Schwarz; Rita Mittnacht-Kraus; Andreas Gaumann; Rainer V Haberberger; Susanne Herold; Georg Breier; Friedrich Grimminger; Werner Seeger; Robert Voswinckel
Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.
American journal of respiratory cell and molecular biology 2008;39(2):163-70.
2008: Ying-Ju Lai; Soni Pullamsetti; Eva Dony; Norbert Weissmann; Ghazwan Butrous; Gamal-Andre Banat; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2008;178(2):188-96.
2008: Haiying Yu; Melanie Königshoff; Aparna Jayachandran; Dan Handley; Werner Seeger; Naftali Kaminski; Oliver Eickelberg
Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1778-89.
2008: István Vadász; Ralph Theo Schermuly; Hossein A Ghofrani; Sebastian Rummel; Susan Wehner; Inge Mühldorfer; Klaus P Schäfer; Werner Seeger; Rory Morty; Friedrich Grimminger; Norbert Weissmann
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.
Critical care medicine 2008;36(5):1543-50.
2008: Kerstin Lahnstein; Thomas Schmehl; Ute Rüsch; Monika Rieger; Werner Seeger; Tobias Gessler
Pulmonary absorption of aerosolized fluorescent markers in the isolated rabbit lung.
International journal of pharmaceutics 2008;351(1-2):158-64.
2008: Tobias Gessler; Werner Seeger; Thomas Schmehl
Inhaled prostanoids in the therapy of pulmonary hypertension.
Journal of aerosol medicine and pulmonary drug delivery 2008;21(1):1-12.
2008: Konstantin Mayer; Werner Seeger
Fish oil in critical illness.
Current opinion in clinical nutrition and metabolic care 2008;11(2):121-7.
2008: Eva Dony; Y-J Lai; Rio Dumitrascu; Soni Pullamsetti; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; D Flockerzi; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(3):599-610.
2008: Richard Schulz; Hans Joachim Eisele; Frank Reichenberger; Werner Seeger
[Obstructive sleep apnoea and metabolic syndrome].
Pneumologie (Stuttgart, Germany) 2008;62(2):88-91.
2008: István Vadász; Laura A Dada; Arturo Briva; Humberto Trejo; Lynn C Welch; Jiwang Chen; Péter T Tóth; Emilia Lecuona; Lee A Witters; Paul T Schumacker; Navdeep S Chandel; Werner Seeger; Jacob I Sznajder
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
The Journal of clinical investigation 2008;118(2):752-62.
2008: Rio Dumitrascu; Silke Koebrich; Eva Dony; Norbert Weissmann; Rajkumar Savai; Soni Pullamsetti; Hossein A Ghofrani; Arun Samidurai; Heiko Traupe; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
BMC pulmonary medicine 2008;8():25.
2008: Melanie Königshoff; Nisha Balsara; Eva-Maria Pfaff; Monika Kramer; Izabella Chrobak; Werner Seeger; Oliver Eickelberg
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis.
PloS one 2008;3(5):e2142.
2008: Fotini M Kouri; Markus A Queisser; Melanie Königshoff; Izabella Chrobak; Klaus T Preissner; Werner Seeger; Oliver Eickelberg
Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension.
The international journal of biochemistry & cell biology 2008;40(9):1872-82.
2008: Miguel A Alejandre-Alcázar; Matthias Michiels-Corsten; Alfin Vicencio IV; Irwin Reiss; Julie Ryu; Ronald R de Krijger; Gabriel G Haddad; Dick Tibboel; Werner Seeger; Oliver Eickelberg; Rory Morty
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(1):259-69.
2008: Ladislau Kiss; Yasmin Röder; Jens Bier; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection.
Analytical and bioanalytical chemistry 2008;390(2):697-714.
2008: Kamila Kitowska; Dariusz Zakrzewicz; Melanie Königshoff; Izabella Chrobak; Friedrich Grimminger; Werner Seeger; Patrick Bulau; Oliver Eickelberg
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L34-45.
2008: Maciej Cabanski; Mirko Steinmüller; Leigh M Marsh; Ewa Surdziel; Werner Seeger; Jürgen Lohmeyer
PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.
American journal of respiratory cell and molecular biology 2008;38(1):26-31.
2007: Melanie Königshoff; Anke Wilhelm; Andreas Jahn; Daniel G Sedding; Oana V Amarie; Bastian Eul; Werner Seeger; Ludger Fink; Andreas Günther; Oliver Eickelberg; Frank Rose
The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis.
American journal of respiratory cell and molecular biology 2007;37(6):640-50.
2007: Frank Reichenberger; Markus G Kohstall; Timon Seeger; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.
Respiratory physiology & neurobiology 2007;159(2):196-201.
2007: Werner von Wulffen; Mirko Steinmueller; Susanne Herold; Leigh M Marsh; Patrick Bulau; Werner Seeger; Tobias Welte; Jürgen Lohmeyer; Ulrich A Maus
Lung dendritic cells elicited by Fms-like tyrosine 3-kinase ligand amplify the lung inflammatory response to lipopolysaccharide.
American journal of respiratory and critical care medicine 2007;176(9):892-901.
2007: Frank Reichenberger; Robert Voswinckel; Beate Enke; M Rutsch; E El Fechtali; Thomas Schmehl; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; E Mayer; Werner Seeger
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(5):922-7.
2007: Miguel A Alejandre-Alcázar; Petar D Shalamanov; Oana V Amarie; Julia Sevilla-Pérez; Werner Seeger; Oliver Eickelberg; Rory Morty
Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(10):2825-35.
2007: Norbert Weissmann; Boris Gerigk; Ozlem Kocer; Matthias Nollen; Sascha Hackemack; Hossein A Ghofrani; Ralph Theo Schermuly; Ghazwan Butrous; Andreas Schulz; Markus Roth; Werner Seeger; Friedrich Grimminger
Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.
Respiratory medicine 2007;101(10):2125-32.
2007: Manish Mittal; Markus Roth; Peter König; Simone Hofmann; Eva Dony; Parag Goyal; Anne-Christin Selbitz; Ralph Theo Schermuly; Hossein A Ghofrani; Grazyna Kwapiszewska; Wolfgang Kummer; Walter Klepetko; Mir Ali Reza Hoda; Ludger Fink; Jörg Hänze; Werner Seeger; Friedrich Grimminger; Harald Schmidt; Norbert Weissmann
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Circulation research 2007;101(3):258-67.
2007: Rory Morty; Oliver Eickelberg; Werner Seeger
Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?
Intensive care medicine 2007;33(7):1229-40.
2007: Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Thorsten Colaris; Bhola Dahal; Dieter Walmrath; Heinz-W Harbach; Jochen Wilhelm; Werner Seeger; Reinhold Schmidt; Andreas Guenther
Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids.
Thorax 2007;62(7):588-94.
2007: Anna Zakrzewicz; Matthias Hecker; Leigh M Marsh; Grazyna Kwapiszewska; Bozena Nejman; Lu Long; Werner Seeger; Ralph Theo Schermuly; Nicholas W Morrell; Rory Morty; Oliver Eickelberg
Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
Circulation 2007;115(23):2957-68.
2007: H G Lasch; Werner Seeger
[The development of internal medicine. Observations within the context of all medicine and future prospects].
Der Internist 2007;48 Suppl 1():S13-6.
2007: Anna Zakrzewicz; Fotini M Kouri; Bozena Nejman; Grazyna Kwapiszewska; Matthias Hecker; R Sandu; Eva Dony; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg; Rory Morty
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(6):1094-104.
2007: Malgorzata Wygrecka; Philipp Markart; Clemens Ruppert; K Petri; Klaus T Preissner; Werner Seeger; Andreas Guenther
Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(6):1105-14.
2007: Jörg Hänze; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Frank Rose
Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.
Thrombosis and haemostasis 2007;97(5):774-87.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Grazyna Kwapiszewska; Rio Dumitrascu; Xia Tian; Norbert Weissmann; Hossein A Ghofrani; Christina Kaulen; Torsten R Dunkern; Christian Schudt; Robert Voswinckel; Jiang Zhou; Arun Samidurai; Walter Klepetko; Renate Paddenberg; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2007: Rory Morty; Bozena Nejman; Grazyna Kwapiszewska; Matthias Hecker; Anna Zakrzewicz; Fotini M Kouri; Dorothea M Peters; Rio Dumitrascu; Werner Seeger; Petra Knaus; Ralph Theo Schermuly; Oliver Eickelberg
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1072-8.
2007: Ulrich A Maus; Myriam Backi; Christine Winter; manjita srivastava; Matthias K Schwarz; Thomas Rückle; James C Paton; David E Briles; Matthias Mack; Tobias Welte; Regina Maus; Rainer M Bohle; Werner Seeger; Christian Rommel; Emilio Hirsch; Jürgen Lohmeyer; Klaus T Preissner
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.
American journal of respiratory and critical care medicine 2007;175(9):958-66.
2007: Susanne Greschus; Rajkumar Savai; Joachim Claudius Wolf; Frank Rose; Werner Seeger; Paul Fitzgerald; Heiko Traupe
Non-invasive screening of lung nodules in mice comparing a novel volumetric computed tomography with a clinical multislice CT.
Oncology reports 2007;17(4):707-12.
2007: Andreas Günther; Beate Enke; Philipp Markart; P Hammerl; Harald Morr; Jürgen Behr; Gerd Stähler; Werner Seeger; Friedrich Grimminger; I Leconte; S Roux; Hossein A Ghofrani
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):713-9.
2007: Martina Barbara Schaefer; Juliane Ott; Andrea Mohr; Ming Hua Bi; Andrea Grosz; Norbert Weissmann; Satoshi Ishii; Friedrich Grimminger; Werner Seeger; Konstantin Mayer
Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury--role of platelet-activating factor receptor.
Critical care medicine 2007;35(2):544-54.
2007: Miguel A Alejandre-Alcázar; Grazyna Kwapiszewska; Irwin Reiss; Oana V Amarie; Leigh M Marsh; Julia Sevilla-Pérez; Malgorzata Wygrecka; Bastian Eul; Silke Köbrich; Mareike Hesse; Ralph Theo Schermuly; Werner Seeger; Oliver Eickelberg; Rory Morty
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia.
American journal of physiology. Lung cellular and molecular physiology 2007;292(2):L537-49.
2007: Reinhold Schmidt; Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Tim Kuchenbuch; Dieter Walmrath; Werner Seeger; Andreas Guenther
Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration.
Respiratory research 2007;8():55.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Susanne C Breitenbach; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; Sigrid M Nilius; Karsten Schrör; Jutta M Kirchrath; Werner Seeger; Frank Rose
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Respiratory research 2007;8():4.
2007: Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Reinhold Schmidt; Martina Korfei; Heinz-W Harbach; I Theruvath; Ulrich Pison; Werner Seeger; Andreas Guenther; H Witt
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(1):134-7.
2006: manda krishnaveni; Jakob Lerche Hansen; Werner Seeger; Rory Morty; Søren P Sheikh; Oliver Eickelberg
Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor.
Biochemical and biophysical research communications 2006;351(3):651-7.
2006: Norbert Weissmann; Alexander Dietrich; Beate Fuchs; Hermann Kalwa; Mahmut Ay; Rio Dumitrascu; Andrea Olschewski; Ursula Storch; Michael Mederos y Schnitzler; Hossein A Ghofrani; Ralph Theo Schermuly; Olaf Pinkenburg; Werner Seeger; Friedrich Grimminger; Thomas Gudermann
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19093-8.
2006: Robert Voswinckel; Beate Enke; Frank Reichenberger; Markus G Kohstall; André Kreckel; Stefanie Krick; Henning Gall; Tobias Gessler; Thomas Schmehl; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Horst Olschewski
Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology 2006;48(8):1672-81.
2006: Clemens Ruppert; Ariane Bagheri; Philipp Markart; Reinhold Schmidt; Werner Seeger; Andreas Günther
Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.
Biochemical and biophysical research communications 2006;348(4):1449-54.
2006: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Norbert Weissmann; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.
Cardiovascular research 2006;72(1):30-40.
2006: Reinhold Schmidt; Philipp Markart; Clemens Ruppert; Bettina Temmesfeld; Robert Nass; Jürgen Lohmeyer; Werner Seeger; Andreas Günther
Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome.
Critical care medicine 2006;34(9):2370-6.
2006: Frank Reichenberger; Robert Voswinckel; E Steveling; Beate Enke; André Kreckel; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Sildenafil treatment for portopulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):563-7.
2006: Norbert Weissmann; Natascha Sommer; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Cardiovascular research 2006;71(4):620-9.
2006: Susanne Herold; Werner von Wulffen; Mirko Steinmueller; Stephan Pleschka; William Kuziel; Matthias Mack; manjita srivastava; Werner Seeger; Ulrich A Maus; Jürgen Lohmeyer
Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1817-24.
2006: Ulrich A Maus; Simeon Janzen; Gerhard Wall; manjita srivastava; Timothy S Blackwell; John W Christman; Werner Seeger; Tobias Welte; Jürgen Lohmeyer
Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation.
American journal of respiratory cell and molecular biology 2006;35(2):227-35.
2006: Philipp Markart; Werner Seeger; A Günther
[Differential therapy of pulmonary fibrosis].
Der Internist 2006;47 Suppl 1():S26-32.
2006: Jochen Wilhelm; Jai Prakash Muyal; Johannes Best; Grazyna Kwapiszewska; Maria Magdalena Stein; Werner Seeger; Rainer M Bohle; Ludger Fink
Systematic comparison of the T7-IVT and SMART-based RNA preamplification techniques for DNA microarray experiments.
Clinical chemistry 2006;52(6):1161-7.
2006: Andrea Olschewski; Yingji Li; Bi Tang; Jörg Hanze; Bastian Eul; Rainer M Bohle; Jochen Wilhelm; Rory Morty; Michael E Brau; E Kenneth Weir; Grazyna Kwapiszewska; Walter Klepetko; Werner Seeger; Horst Olschewski
Impact of TASK-1 in human pulmonary artery smooth muscle cells.
Circulation research 2006;98(8):1072-80.
2006: Hossein A Ghofrani; R T Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
[Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(16):871-4.
2006: Robert Voswinckel; K Ahlbrecht; J C Wolff; Norbert Weissmann; Heinz Fehrenbach; A O Yildirim; Friedrich Grimminger; Werner Seeger
[Pulmonary tissue regeneration -- a hope for the future].
Deutsche medizinische Wochenschrift (1946) 2006;131(16):865-8.
2006: Richard Schulz; Mathias Grebe; Hans Joachim Eisele; Konstantin Mayer; Norbert Weissmann; Werner Seeger
[Obstructive sleep apnea-related cardiovascular disease].
Medizinische Klinik (Munich, Germany : 1983) 2006;101(4):321-7.
2006: Andreas Günther; Philipp Markart; Oliver Eickelberg; Werner Seeger
[Pulmonary fibrosis--a therapeutic dilemma?].
Medizinische Klinik (Munich, Germany : 1983) 2006;101(4):308-12.
2006: Mathias Grebe; Hans Joachim Eisele; Norbert Weissmann; Claudia Schaefer; Harald Tillmanns; Werner Seeger; Richard Schulz
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2006;173(8):897-901.
2006: Soni Pullamsetti; Daniel Maring; Hossein A Ghofrani; Konstantin Mayer; Norbert Weissmann; Bernhard Rosengarten; Martin Lehner; Christian Schudt; Rainer Boer; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2006: Konstantin Mayer; M Schaefer; H Walmrath; Friedrich Grimminger; Werner Seeger
[Nutrition and immunonutrition in septic patients].
Der Internist 2006;47(4):374, 376-82.
2006: Norbert Weissmann; Stefanie Zeller; Rolf Schäfer; Carmen Turowski; Mahmut Ay; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Friedrich Grimminger
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
American journal of respiratory cell and molecular biology 2006;34(4):505-13.
2006: Aparna Renigunta; Gabriela Krasteva; Peter König; Frank Rose; Walter Klepetko; Friedrich Grimminger; Werner Seeger; Jörg Hänze
DNA transfer into human lung cells is improved with Tat-RGD peptide by caveoli-mediated endocytosis.
Bioconjugate chemistry 2006;17(2):327-34.
2006: Rajkumar Savai; Ralph Theo Schermuly; Michael Schneider; Soni Pullamsetti; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat
Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):175-87.
2006: Katja Hattar; Ulrich Grandel; Alexander Moeller; Ludger Fink; Julia Iglhaut; Thomas Hartung; Siegfried Morath; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.
Critical care medicine 2006;34(3):835-41.
2006: Richard Schulz; Christiane Flötotto; Andreas Jahn; Hans Joachim Eisele; Norbert Weissmann; Werner Seeger; Frank Rose
Circulating adrenomedullin in obstructive sleep apnoea.
Journal of sleep research 2006;15(1):89-95.
2006: Konstantin Mayer; Martina Barbara Schaefer; Werner Seeger
Fish oil in the critically ill: from experimental to clinical data.
Current opinion in clinical nutrition and metabolic care 2006;9(2):140-8.
2006: Aparna Renigunta; Christiane Hild; Frank Rose; Walter Klepetko; Friedrich Grimminger; Werner Seeger; Jörg Hänze
Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia.
FEBS letters 2006;580(3):900-3.
2006: Rio Dumitrascu; Norbert Weissmann; Hossein A Ghofrani; Eva Dony; Knut Beuerlein; Harald Schmidt; Johannes-Peter Stasch; Mark J Gnoth; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Circulation 2006;113(2):286-95.
2006: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Christina Susanne Breitenbach; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Werner Seeger
Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):353-63.
2006: Norbert Weissmann; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Parag Goyal; Friedrich Grimminger; Werner Seeger
Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
Novartis Foundation symposium 2006;272():196-208; discussion 208-17.
2006: Mirko Steinmüller; manjita srivastava; William Kuziel; John W Christman; Werner Seeger; Tobias Welte; Jürgen Lohmeyer; Ulrich A Maus
Endotoxin induced peritonitis elicits monocyte immigration into the lung: implications on alveolar space inflammatory responsiveness.
Respiratory research 2006;7():30.
2006: Bernhard Rosengarten; Ralph Theo Schermuly; Robert Voswinckel; Markus G Kohstall; Horst Olschewski; Norbert Weissmann; Werner Seeger; Manfred Kaps; Friedrich Grimminger; Hossein A Ghofrani
Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(3):194-200.
2006: Ulrich Grandel; Robin Benkelmann; Michael Buerke; Ladislau Kiss; Katja Hattar; Konstantin Mayer; Martina Heep; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Free arachidonic versus eicosapentaenoic acid differentially influences the potency of bacterial exotoxins to provoke myocardial depression in isolated rat hearts.
Critical care medicine 2006;34(1):118-26.
2006: Bastian Eul; Frank Rose; Stefanie Krick; Rajkumar Savai; Parag Goyal; Walter Klepetko; Friedrich Grimminger; Norbert Weissmann; Werner Seeger; Jörg Hänze
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):163-5.
2005: Ulrike Seay; Daniel G Sedding; Stefanie Krick; Matthias Hecker; Werner Seeger; Oliver Eickelberg
Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1005-12.
2005: Rory Morty; István Vadász; Patrick Bulau; Vincent Dive; Vitor Oliveira; Werner Seeger; Luiz Juliano
Tropolysin, a new oligopeptidase from African trypanosomes.
Biochemistry 2005;44(44):14658-69.
2005: Ralph Theo Schermuly; Eva Dony; Hossein A Ghofrani; Soni Pullamsetti; Rajkumar Savai; Markus Roth; Akylbek Sydykov; Ying Ju Lai; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Reversal of experimental pulmonary hypertension by PDGF inhibition.
The Journal of clinical investigation 2005;115(10):2811-21.
2005: Rajkumar Savai; Joachim C Wolf; Susanne Greschus; Bastian Eul; Ralph Theo Schermuly; Jörg Hänze; Robert Voswinckel; Alexander C Langheinrich; Friedrich Grimminger; Heiko Traupe; Werner Seeger; Frank Rose
Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography.
The American journal of pathology 2005;167(4):937-46.
2005: István Vadász; Rory Morty; Andrea Olschewski; Melanie Königshoff; Markus G Kohstall; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase.
American journal of respiratory cell and molecular biology 2005;33(4):343-54.
2005: Katja Hattar; Sandra van Bürck; Annette Bickenbach; Ulrich Grandel; Ulrich A Maus; Jürgen Lohmeyer; Elena Csernok; Thomas Hartung; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Journal of leukocyte biology 2005;78(4):992-1000.
2005: Norbert Weissmann; Daniel Manz; Daniela Buchspies; Stephan Keller; Tanja Mehling; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Max Gassmann; Friedrich Grimminger
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Thrombosis and haemostasis 2005;94(3):630-8.
2005: Georg Friese; Jürgen Lohmeyer; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[HIV-associated pulmonary hypertension ].
Herz 2005;30(6):481-5.
2005: Ulrich Grandel; Michael Hopf; Michael Buerke; Katja Hattar; Martina Heep; Ludger Fink; Rainer M Bohle; Siegfried Morath; Thomas Hartung; Soni Pullamsetti; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.
Circulation 2005;112(5):691-8.
2005: Philipp Markart; L Hundack; Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Andreas Günther
[Idiopathic interstitial pneumonias: pathomechanisms and therapeutic options].
Pneumologie (Stuttgart, Germany) 2005;59(8):554-61.
2005: manjita srivastava; Steffen Jung; Jochen Wilhelm; Ludger Fink; Frank Bühling; Tobias Welte; Rainer M Bohle; Werner Seeger; Jürgen Lohmeyer; Ulrich A Maus
The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1884-93.
2005: Rajkumar Savai; Ralph Theo Schermuly; Robert Voswinckel; Aparna Renigunta; Bernd Reichmann; Bastian Eul; Friedrich Grimminger; Werner Seeger; Frank Rose; Jörg Hänze
HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model.
International journal of oncology 2005;27(2):393-400.
2005: Ralph Theo Schermuly; Hüseyin Yilmaz; Hossein A Ghofrani; Kathrin Woyda; Soni Pullamsetti; Andreas Schulz; Tobias Gessler; Rio Dumitrascu; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(3):358-63.
2005: Oliver Eickelberg; Werner Seeger
[Pulmonary hypertension: pathophysiology, genetics and functional genomics].
Der Internist 2005;46(7):759-68.
2005: Soni Pullamsetti; Ladislau Kiss; Hossein A Ghofrani; Robert Voswinckel; Peter Haredza; Walter Klepetko; Clemens Aigner; Ludger Fink; Jai Prakash Muyal; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1175-7.
2005: Werner Seeger
[Pneumology -- from phthisiology to regenerative medicine].
Deutsche medizinische Wochenschrift (1946) 2005;130(25-26):1543-6.
2005: Stefanie Krick; Jörg Hänze; Bastian Eul; Rajkumar Savai; Ulrike Seay; Friedrich Grimminger; Jürgen Lohmeyer; Walter Klepetko; Werner Seeger; Frank Rose
Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):857-9.
2005: Stefanie Krick; Bastian Eul; Jörg Hänze; Rajkumar Savai; Friedrich Grimminger; Werner Seeger; Frank Rose
Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.
American journal of respiratory cell and molecular biology 2005;32(5):395-403.
2005: Richard Schulz; Hans Joachim Eisele; Norbert Weissmann; Werner Seeger
[Pulmonary hypertension and sleep-related breathing disorders].
Pneumologie (Stuttgart, Germany) 2005;59(4):270-4.
2005: Parag Goyal; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Hans J Schäfers; Werner Seeger; Jörg Hänze
Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.
Biochemical and biophysical research communications 2005;329(1):32-9.
2005: Rory Morty; Roger Pellé; István Vadász; Graciela L Uzcanga; Werner Seeger; José Bubis
Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts.
The Journal of biological chemistry 2005;280(12):10925-37.
2005: Horst Olschewski; Ardeschir Ghofrani; Beate Enke; Frank Reichenberger; Robert Voswinckel; André Kreckel; Stefanie Ghofrani; Ralph Wiedemann; R Schulz; Friedrich Grimminger; Werner Seeger
[Therapy of pulmonary arterial hypertension].
Der Internist 2005;46(3):341-9.
2005: István Vadász; Rory Morty; Markus G Kohstall; Andrea Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
American journal of respiratory and critical care medicine 2005;171(5):469-79.
2005: Richard Schulz; Hans Joachim Eisele; Werner Seeger
Nocturnal atrial fibrillation in a patient with obstructive sleep apnoea.
Thorax 2005;60(2):174.
2005: Ulrich A Maus; Sandra Wellmann; Christine Hampl; William Kuziel; manjita srivastava; Matthias Mack; M Brett Everhart; Timothy S Blackwell; John W Christman; Detlef Schlöndorff; Rainer M Bohle; Werner Seeger; Jürgen Lohmeyer
CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels.
American journal of physiology. Lung cellular and molecular physiology 2005;288(2):L350-8.
2005: Soni Pullamsetti; Stefanie Krick; Hüseyin Yilmaz; Hossein A Ghofrani; Christian Schudt; Norbert Weissmann; Beate Fuchs; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Grazyna Kwapiszewska; Jochen Wilhelm; Stephanie Wolff; Isabel Laumanns; Inke R Koenig; Andreas Ziegler; Werner Seeger; Rainer M Bohle; Norbert Weissmann; Ludger Fink
Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension.
Respiratory research 2005;6():109.
2005: Norbert Weissmann; Nermin Kuzkaya; Beate Fuchs; Vedat Tiyerili; Rolf Schäfer; Hartwig Schütte; Hossein A Ghofrani; Ralph Theo Schermuly; Christian Schudt; Akylbek Sydykov; Bakytbek Egemnazarow; Werner Seeger; Friedrich Grimminger
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2005: Ralph Theo Schermuly; Christiane Inholte; Hossein A Ghofrani; Henning Gall; Norbert Weissmann; Andreas Weidenbach; Werner Seeger; Friedrich Grimminger
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Respiratory research 2005;6():76.
2005: Richard Schulz; Werner Seeger; Christine Fegbeutel; H Hüsken; Rolf-Hasso Bödeker; Harald Tillmanns; Mathias Grebe
Changes in extracranial arteries in obstructive sleep apnoea.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(1):69-74.
2004: Grazyna Kwapiszewska; Markus Meyer; Ralf Bogumil; Rainer M Bohle; Werner Seeger; Norbert Weissmann; Ludger Fink
Identification of proteins in laser-microdissected small cell numbers by SELDI-TOF and Tandem MS.
BMC biotechnology 2004;4():30.
2004: Lars Bode; Clemens Kunz; Marion Muhly-Reinholz; Konstantin Mayer; Werner Seeger; Silvia Rudloff
Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides.
Thrombosis and haemostasis 2004;92(6):1402-10.
2004: Reinhold Schmidt; T Luboeinski; Philipp Markart; Clemens Ruppert; C Daum; Friedrich Grimminger; Werner Seeger; Andreas Günther
Alveolar antioxidant status in patients with acute respiratory distress syndrome.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(6):994-9.
2004: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Horst Olschewski; Peter Haredza; Burcu Karadaş; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Journal of the American College of Cardiology 2004;44(7):1488-96.
2004: Robert Voswinckel; V Motejl; Antonia Fehrenbach; Michael Wegmann; Tanja Mehling; Heinz Fehrenbach; Werner Seeger
Characterisation of post-pneumonectomy lung growth in adult mice.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(4):524-32.
2004: Malgorzata Wygrecka; Philipp Markart; Clemens Ruppert; Tim Kuchenbuch; Ludger Fink; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Andreas Günther
Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.
Thrombosis and haemostasis 2004;92(3):529-40.
2004: Hossein A Ghofrani; Frank Reichenberger; Markus G Kohstall; Eike Mrosek; Timon Seeger; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial.
Annals of internal medicine 2004;141(3):169-77.
2004: Ulrich A Maus; manjita srivastava; James C Paton; Matthias Mack; M Brett Everhart; Timothy S Blackwell; John W Christman; Detlef Schlöndorff; Werner Seeger; Jürgen Lohmeyer
Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1307-12.
2004: Werner Seeger; R Schulz
[Inhalation combination therapy in chronic obstructive lung disease. TRISTAN-study].
Der Internist 2004;45(6):727-8.
2004: Parag Goyal; Norbert Weissmann; Friedrich Grimminger; Cornelia Hegel; Lucius Bader; Frank Rose; Ludger Fink; Hossein A Ghofrani; Ralph Theo Schermuly; Harald Schmidt; Werner Seeger; Jörg Hänze
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
Free radical biology & medicine 2004;36(10):1279-88.
2004: Horst Olschewski; Frank Rose; Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Andrea Olschewski; Werner Seeger
Prostacyclin and its analogues in the treatment of pulmonary hypertension.
Pharmacology & therapeutics 2004;102(2):139-53.
2004: Ralph Theo Schermuly; Klaus Peter Kreisselmeier; Hossein A Ghofrani; Arun Samidurai; Soni Pullamsetti; Norbert Weissmann; Christian Schudt; Leander Ermert; Werner Seeger; Friedrich Grimminger
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2004: Norbert Weissmann; Henrik Vogels; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Ludger Fink; Frank Rose; Werner Seeger; Friedrich Grimminger
Measurement of exhaled hydrogen peroxide from rabbit lungs.
Biological chemistry 2004;385(3-4):259-64.
2004: Reinhold Schmidt; Clemens Ruppert; Philipp Markart; Norbert Lübke; Leander Ermert; Norbert Weissmann; Andreas Breithecker; Monika Ermert; Werner Seeger; Andreas Günther
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.
Toxicology and applied pharmacology 2004;195(2):218-31.
2004: Hossein A Ghofrani; Georg Friese; Thomas Discher; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(2):321-6.
2004: Andreas Günther; Markus Balser; Reinhold Schmidt; Philipp Markart; Alexander Olk; Jochen Börgermann; Fred H Splittgerber; Werner Seeger; Ivar Friedrich
Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration.
The Journal of thoracic and cardiovascular surgery 2004;127(2):344-54.
2004: Ivar Friedrich; Jochen Börgermann; Fred H Splittgerber; Matthias Brinkmann; Jürgen Christoph Reidemeister; Rolf-Edgar Silber; Werner Seeger; Reinhold Schmidt; Andreas Günther
Bronchoscopic surfactant administration preserves gas exchange and pulmonary compliance after single lung transplantation in dogs.
The Journal of thoracic and cardiovascular surgery 2004;127(2):335-43.
2004: Norbert Weissmann; Ercan Akkayagil; Karin Quanz; Ralph Theo Schermuly; Hossein A Ghofrani; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Basic features of hypoxic pulmonary vasoconstriction in mice.
Respiratory physiology & neurobiology 2004;139(2):191-202.
2004: Reinhold Schmidt; Christoph Schäfer; Thomas Luboeinski; Alexander Löckinger; Gerd Hermle; Friedrich Grimminger; Werner Seeger; Ardeschir Ghofrani; Hartwig Schütte; Andreas Günther
Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia.
Free radical biology & medicine 2004;36(1):78-89.
2004: Richard Schulz; Christine Fegbeutel; Horst Olschewski; Frank Rose; Hans-Joachim Schäfers; Werner Seeger
Reversal of nocturnal periodic breathing in primary pulmonary hypertension after lung transplantation.
Chest 2004;125(1):344-7.
2004: Heidrun Muth; Ulrich A Maus; Malgorzata Wygrecka; Jürgen Lohmeyer; Friedrich Grimminger; Werner Seeger; Andreas Günther
Pro- and antifibrinolytic properties of human pulmonary microvascular versus artery endothelial cells: impact of endotoxin and tumor necrosis factor-alpha.
Critical care medicine 2004;32(1):217-26.
2004: Ralph Theo Schermuly; Klaus P Kreisselmeier; Hossein A Ghofrani; Hüseyin Yilmaz; Ghazwan Butrous; Leander Ermert; Monika Ermert; Norbert Weissmann; Frank Rose; Andreas Guenther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):39-45.
2003: Jörg Hänze; Bastian Eul; Rajkumar Savai; Stefanie Krick; Parag Goyal; Friedrich Grimminger; Werner Seeger; Frank Rose
RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation.
Biochemical and biophysical research communications 2003;312(3):571-7.
2003: Andreas Günther; Norbert Lübke; Monika Ermert; Ralph Theo Schermuly; Norbert Weissmann; Andreas Breithecker; Philipp Markart; Clemens Ruppert; Karin Quanz; Leander Ermert; Friedrich Grimminger; Werner Seeger
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.
American journal of respiratory and critical care medicine 2003;168(11):1358-65.
2003: Norbert Weissmann; Nadine Ebert; Marit Ahrens; Hossein A Ghofrani; Ralph Theo Schermuly; Jörg Hänze; Ludger Fink; Frank Rose; Jörg Conzen; Werner Seeger; Friedrich Grimminger
Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2003;29(6):721-32.
2003: Konstantin Mayer; Sandra Meyer; Marion Reinholz-Muhly; Ulrich A Maus; Martina Merfels; Jürgen Lohmeyer; Friedrich Grimminger; Werner Seeger
Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4837-43.
2003: Konstantin Mayer; Christine Fegbeutel; Katja Hattar; Ulf Sibelius; Hans-Joachim Krämer; Kai-Uwe Heuer; Bettina Temmesfeld-Wollbrück; Stephanie Gokorsch; Friedrich Grimminger; Werner Seeger
Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation.
Intensive care medicine 2003;29(9):1472-81.
2003: Robert Voswinckel; Tibor Ziegelhoeffer; Matthias Heil; Sawa Kostin; Georg Breier; Tanja Mehling; Rainer V Haberberger; Matthias Clauss; Andreas Gaumann; Wolfgang Schaper; Werner Seeger
Circulating vascular progenitor cells do not contribute to compensatory lung growth.
Circulation research 2003;93(4):372-9.
2003: Ralph Theo Schermuly; H Leuchte; Hossein A Ghofrani; Norbert Weissmann; Frank Rose; Markus G Kohstall; Horst Olschewski; Christian Schudt; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(2):342-7.
2003: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; André Kreckel; Norbert Weissmann; Stefanie Ghofrani; Beate Enke; Werner Seeger; Friedrich Grimminger
Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension.
Journal of the American College of Cardiology 2003;42(1):158-64.
2003: Konstantin Mayer; Stephanie Gokorsch; Christine Fegbeutel; Katja Hattar; Simone Rosseau; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis.
American journal of respiratory and critical care medicine 2003;167(10):1321-8.
2003: Monika Ermert; C Pantazis; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger; Leander Ermert
In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue.
Cytokine 2003;22(3-4):89-100.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Kerstin Seibold; Ariane Bagheri; Friedrich Grimminger; Werner Seeger; Andreas Günther
Impact of surface tension on the conversion rate of large to small surfactant aggregates.
Biophysical chemistry 2003;104(1):229-38.
2003: Hossein A Ghofrani; Ralph Theo Schermuly; Frank Rose; Ralph Wiedemann; Markus G Kohstall; André Kreckel; Horst Olschewski; Norbert Weissmann; Beate Enke; Stefanie Ghofrani; Werner Seeger; Friedrich Grimminger
Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.
American journal of respiratory and critical care medicine 2003;167(8):1139-41.
2003: Richard Schulz; Christine Fegbeutel; Andre Althoff; Heiko Traupe; Friedrich Grimminger; Werner Seeger
Central sleep apnoea and unilateral diaphragmatic paralysis associated with vertebral artery compression of the medulla oblongata.
Journal of neurology 2003;250(4):503-5.
2003: Hartwig Schütte; Alexander Schell; Christoph Schäfer; Ardeschir Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Subthreshold doses of nebulized prostacyclin and rolipram synergistaically protect against lung ischemia-reperfusion.
Transplantation 2003;75(6):814-21.
2003: Ulrich A Maus; Katharina Waelsch; William Kuziel; Tim Delbeck; Matthias Mack; Timothy S Blackwell; John W Christman; Detlef Schlöndorff; Werner Seeger; Jürgen Lohmeyer
Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3273-8.
2003: Monika Ermert; Daniel Kuttner; Nils Eisenhardt; Christian Dierkes; Werner Seeger; Leander Ermert
Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs.
Laboratory investigation; a journal of technical methods and pathology 2003;83(3):333-47.
2003: Ulf Sibelius; Ulrich Grandel; Michael Buerke; Ladislau Kiss; Pascal Klingenberger; Martina Heep; Emmanoyil Bournelis; Werner Seeger; Friedrich Grimminger
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Critical care medicine 2003;31(3):683-8.
2003: Norbert Weissmann; Matthias Nollen; Boris Gerigk; Hossein Ardeschir Ghofrani; Ralph Theo Schermuly; Andreas Gunther; Karin Quanz; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H931-8.
2003: Bernd Friedrich; Reinhold Schmidt; Irwin Reiss; Andreas Günther; Werner Seeger; Matthias Müller; Josef Thul; Dietmar Schranz; Ludwig Gortner
Changes in biochemical and biophysical surfactant properties with cardiopulmonary bypass in children.
Critical care medicine 2003;31(1):284-90.
2003: Clemens Ruppert; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Claus-Michael Lehr; Andreas Günther
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.
Thrombosis and haemostasis 2003;89(1):53-64.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Jörg Stürzebecher; Andreas Günther
Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type.
American journal of respiratory cell and molecular biology 2003;28(1):95-102.
2003: Philipp Markart; Clemens Ruppert; Friedrich Grimminger; Werner Seeger; Andreas Günther
Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L69-76.
2002: Horst Olschewski; Ardeschir Ghofrani; Ralph Wiedemann; Frank Rose; Beate Enke; Tobias Gessler; Robert Voswinckel; Markus G Kohstall; Friedrich Grimminger; Werner Seeger
[Pulmonary hypertension].
Der Internist 2002;43(12):1498, 1501-9.
2002: Ulrich A Maus; S Henning; H Wenschuh; Konstantin Mayer; Werner Seeger; Jürgen Lohmeyer
Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flow.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2584-91.
2002: Hossein A Ghofrani; Horst Olschewski; Werner Seeger; Friedrich Grimminger
[Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure].
Pneumologie (Stuttgart, Germany) 2002;56(11):665-72.
2002: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; Norbert Weissmann; Christian Schudt; Hermann Tenor; Werner Seeger; Friedrich Grimminger
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Arne Meidow; Frank Rose; Axel Roehl; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs.
The Journal of pharmacology and experimental therapeutics 2002;303(2):741-5.
2002: Reinhold Schmidt; U Meier; Philipp Markart; Friedrich Grimminger; Hans-Georg Velcovsky; Harald Morr; Werner Seeger; Andreas Günther
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L1079-85.
2002: Ulf Sibelius; Katja Hattar; Sabine Hoffmann; Konstantin Mayer; Ulrich Grandel; Angelika Schenkel; Werner Seeger; Friedrich Grimminger
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Critical care medicine 2002;30(10):2306-12.
2002: Frank Rose; Friedrich Grimminger; Jutta Appel; Mathias Heller; Volker Pies; Norbert Weissmann; Ludger Fink; Sebastian Schmidt; Stefanie Krick; Gieri Camenisch; Max Gassmann; Werner Seeger; Jörg Hänze
Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1660-1.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Norbert Weissmann; Andreas Gunther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.
Lancet 2002;360(9337):895-900.
2002: Ulrich A Maus; Karen von Grote; William Kuziel; Matthias Mack; Edmund Miller; Josef Cihak; Manfred Stangassinger; Regina Maus; Detlef Schlöndorff; Werner Seeger; Jürgen Lohmeyer
The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice.
American journal of respiratory and critical care medicine 2002;166(3):268-73.
2002: Frank Rose; Bernd Guthmann; Tobias Tenenbaum; Ludger Fink; Ardeschir Ghofrani; Norbert Weissmann; Peter König; Leander Ermert; Gabriele Dahlem; Joerg Haenze; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Apical, but not basolateral, endotoxin preincubation protects alveolar epithelial cells against hydrogen peroxide-induced loss of barrier function: the role of nitric oxide synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1474-81.
2002: Konstantin Mayer; Martina Merfels; Marion Muhly-Reinholz; Stephanie Gokorsch; Simone Rosseau; Jürgen Lohmeyer; Nicole Schwarzer; Matthias Krüll; Norbert Suttorp; Friedrich Grimminger; Werner Seeger
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H811-8.
2002: Clemens Ruppert; Reinhold Schmidt; Friedrich Grimminger; Yasuhiro Suzuki; Werner Seeger; Claus-Michael Lehr; Andreas Günther
Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.
Bioconjugate chemistry 2002;13(4):804-11.
2002: Katja Hattar; Annette Bickenbach; Elena Csernok; Simone Rosseau; Ulrich Grandel; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation.
Journal of leukocyte biology 2002;71(6):996-1004.
2002: Konstantin Mayer; Reinhold Schmidt; Marion Muhly-Reinholz; Tina Bögeholz; Stephanie Gokorsch; Friedrich Grimminger; Werner Seeger
In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFalpha impact of omega-3 versus omega-6 fatty acids.
Journal of lipid research 2002;43(6):944-51.
2002: Ulrich A Maus; M Audrey Koay; Tim Delbeck; Matthias Mack; Monika Ermert; Leander Ermert; Timothy S Blackwell; John W Christman; Detlef Schlöndorff; Werner Seeger; Jürgen Lohmeyer
Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.
American journal of physiology. Lung cellular and molecular physiology 2002;282(6):L1245-52.
2002: Dieter Walmrath; Friedrich Grimminger; D Pappert; C Knothe; U Obertacke; Albert Benzing; Andreas Günther; Thomas Schmehl; H Leuchte; Werner Seeger
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):805-10.
2002: Andreas Günther; Reinhold Schmidt; J Harodt; Thomas Schmehl; Dieter Walmrath; Clemens Ruppert; Friedrich Grimminger; Werner Seeger
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):797-804.
2002: Peter Mayser; Konstantin Mayer; Mojgan Mahloudjian; Steffen Benzing; Hans-Joachim Krämer; Wolf-Bernhard Schill; Werner Seeger; Friedrich Grimminger
A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis.
JPEN. Journal of parenteral and enteral nutrition 2002;26(3):151-8.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.
Annals of internal medicine 2002;136(7):515-22.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):664-71.
2002: Richard Schulz; G Baseler; Hossein A Ghofrani; Friedrich Grimminger; Horst Olschewski; Werner Seeger
Nocturnal periodic breathing in primary pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):658-63.
2002: Monika Ermert; Clemens Ruppert; Andreas Günther; Hans-Rainer Duncker; Werner Seeger; Leander Ermert
Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs.
Laboratory investigation; a journal of technical methods and pathology 2002;82(4):425-41.
2002: Katja Hattar; Ulrich Grandel; Annette Bickenbach; Andreas Schwarting; Werner-Johannes Mayet; Juergen Bux; Sönke Jessen; Claus Fischer; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):3057-64.
2002: Jörg Hänze; David A Groneberg; Frank Rose; Anika Hanisch; Jörg Dötsch; Christian Peiser; Werner Seeger; Wolfgang Rascher; Axel Fischer; Friedrich Grimminger
Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.
Biochemical and biophysical research communications 2002;291(5):1160-5.
2002: Ulrich Grandel; Mathias Reutemann; Ladislau Kiss; Michael Buerke; Ludger Fink; Emmanoyil Bournelis; Martina Heep; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1157-65.
2002: Reinhold Schmidt; Wolfram Steinhilber; Clemens Ruppert; Christina Daum; Friedrich Grimminger; Werner Seeger; Andreas Günther
An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.
American journal of respiratory and critical care medicine 2002;165(4):470-4.
2002: Frank Rose; Gabriele Dahlem; Bernd Guthmann; Friedrich Grimminger; Ulrich A Maus; Jörg Hänze; Nils Duemmer; Ulrich Grandel; Werner Seeger; Hossein A Ghofrani
Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus alpha-toxin.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L207-14.
2002: Tobias Gessler; Thomas Schmehl; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Aerosolized vasodilators in pulmonary hypertension.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):117-22.
2002: Konstantin Mayer; Helmut Grimm; Friedrich Grimminger; Werner Seeger
Parenteral nutrition with n-3 lipids in sepsis.
The British journal of nutrition 2002;87 Suppl 1():S69-75.
2002: Ludger Fink; Stephanie Kohlhoff; Maria Magdalena Stein; Jörg Hänze; Norbert Weissmann; Frank Rose; Ercan Akkayagil; Daniel Manz; Friedrich Grimminger; Werner Seeger; Rainer M Bohle
cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue.
The American journal of pathology 2002;160(1):81-90.
2002: Ulrich A Maus; Julia Huwe; Leander Ermert; Monika Ermert; Werner Seeger; Jürgen Lohmeyer
Molecular pathways of monocyte emigration into the alveolar air space of intact mice.
American journal of respiratory and critical care medicine 2002;165(1):95-100.
2002: Richard Schulz; Christoph Hummel; Sabine Heinemann; Werner Seeger; Friedrich Grimminger
Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia.
American journal of respiratory and critical care medicine 2002;165(1):67-70.
2001: Horst Olschewski; Frank Rose; Ekkehard Grünig; H A Ghofrani; Dieter Walmrath; R Schulz; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Cellular pathophysiology and therapy of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(6):367-77.
2001: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; H Leuchte; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1361-8.
2001: Ralph Theo Schermuly; E Krupnik; Hermann Tenor; Christian Schudt; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Werner Seeger; Dieter Walmrath; Hossein A Ghofrani
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Horst Olschewski; Andrea Olschewski; Frank Rose; Ralph Theo Schermuly; Hartwig Schütte; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Physiologic basis for the treatment of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(5):287-97.
2001: Hartwig Schütte; Martin Witzenrath; Konstantin Mayer; Simone Rosseau; Werner Seeger; Friedrich Grimminger
Short-term "preconditioning" with inhaled nitric oxide protects rabbit lungs against ischemia-reperfusion injury.
Transplantation 2001;72(8):1363-70.
2001: Ralph Wiedemann; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.
Journal of the American College of Cardiology 2001;38(4):1130-6.
2001: Ralph Theo Schermuly; Norbert Weissmann; Beate Enke; Hossein A Ghofrani; W G Forssmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.
American journal of respiratory cell and molecular biology 2001;25(2):219-25.
2001: Hartwig Schütte; Konstantin Mayer; H Burger; Martin Witzenrath; Tobias Gessler; Werner Seeger; Friedrich Grimminger
Endogenous nitric oxide synthesis and vascular leakage in ischemic-reperfused rabbit lungs.
American journal of respiratory and critical care medicine 2001;164(3):412-8.
2001: Ulrich A Maus; J Huwe; Regina Maus; Werner Seeger; Jürgen Lohmeyer
Alveolar JE/MCP-1 and endotoxin synergize to provoke lung cytokine upregulation, sequential neutrophil and monocyte influx, and vascular leakage in mice.
American journal of respiratory and critical care medicine 2001;164(3):406-11.
2001: Hartwig Schütte; Alexander Löckinger; Werner Seeger; Friedrich Grimminger
Aerosolized PGE1, PGI2 and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(1):15-22.
2001: Richard Schulz; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[Obstructive sleep apnea and cardiovascular diseases--hypothesis on the pathophysiological interlinks].
Pneumologie (Stuttgart, Germany) 2001;55(6):295-301.
2001: Katja Hattar; Ludger Fink; K Fietzner; B Himmel; Friedrich Grimminger; Werner Seeger; Ulf Sibelius
Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6287-93.
2001: Hossein A Ghofrani; Markus G Kohstall; Norbert Weissmann; Thomas Schmehl; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Alveolar epithelial barrier functions in ventilated perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L896-904.
2001: Ralph Theo Schermuly; Andreas Günther; Monika Ermert; Leander Ermert; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L792-800.
2001: Norbert Weissmann; S Winterhalder; Matthias Nollen; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L638-45.
2001: Ulrich A Maus; Werner Seeger; Jürgen Lohmeyer
Impact of a phosphorothioate oligodeoxynucleotide MCP-1 on NF-kappaB, AP-1, SP1 and NF-kappaB, and AP-1 subunit composition in human pulmonary endothelial cells.
Antisense & nucleic acid drug development 2001;11(1):59-64.
2001: Frank Rose; S A Zeller; Trinad Chakraborty; Eugen Domann; thomas machleidt; M Kronke; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Human endothelial cell activation and mediator release in response to Listeria monocytogenes virulence factors.
Infection and immunity 2001;69(2):897-905.
2001: Leander Ermert; Andreas C Hocke; Hans-Rainer Duncker; Werner Seeger; Monika Ermert
Comparison of different detection methods in quantitative microdensitometry.
The American journal of pathology 2001;158(2):407-17.
2001: Alexander Löckinger; Hartwig Schütte; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Protection against gas exchange abnormalities by pre-aerosolized PGE1, iloprost and nitroprusside in lung ischemia-reperfusion.
Transplantation 2001;71(2):185-93.
2001: Andreas Günther; Clemens Ruppert; Reinhold Schmidt; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Surfactant alteration and replacement in acute respiratory distress syndrome.
Respiratory research 2001;2(6):353-64.
2001: Tobias Gessler; Thomas Schmehl; M M Hoeper; Frank Rose; Hossein A Ghofrani; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9.
2001: Reinhold Schmidt; U Meier; M Yabut-Perez; Dieter Walmrath; Friedrich Grimminger; Werner Seeger; Andreas Günther
Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia.
American journal of respiratory and critical care medicine 2001;163(1):95-100.
2001: Katja Hattar; Ulf Sibelius; Annette Bickenbach; Elena Csernok; Werner Seeger; Friedrich Grimminger
Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis.
Journal of leukocyte biology 2001;69(1):89-97.
2001: Ulrich Grandel; Ulf Sibelius; J Schrickel; D Schmidt; Michael Buerke; Ludger Fink; Emmanoyil Bournelis; Martina Heep; Konstantin Mayer; Rainer M Bohle; Werner Seeger; Friedrich Grimminger
Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin.
Critical care medicine 2001;29(1):1-7.
2001: Ulrich A Maus; Susanne Herold; Heidrun Muth; Regina Maus; Leander Ermert; Monika Ermert; Norbert Weissmann; Simone Rosseau; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.
American journal of physiology. Lung cellular and molecular physiology 2001;280(1):L58-68.
2000: Richard Schulz; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[Prevalence of stroke and transitory ischemic attacks in obstructive sleep apnea: a retrospective analyis so f 187 consecutive patients].
Pneumologie (Stuttgart, Germany) 2000;54(12):575-9.
2000: Richard Schulz; D Schmidt; A Blum; X Lopes-Ribeiro; C Lücke; Konstantin Mayer; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy.
Thorax 2000;55(12):1046-51.
2000: Ulrich Grandel; Ludger Fink; A Blum; Martina Heep; Michael Buerke; H J Kraemer; Konstantin Mayer; Rainer M Bohle; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production.
Circulation 2000;102(22):2758-64.
2000: Ludger Fink; T Kinfe; Werner Seeger; Leander Ermert; Wolfgang Kummer; Rainer M Bohle
Immunostaining for cell picking and real-time mRNA quantitation.
The American journal of pathology 2000;157(5):1459-66.
2000: Norbert Weissmann; A Tadic; Jörg Hänze; Frank Rose; S Winterhalder; Matthias Nollen; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L683-90.
2000: Hartwig Schütte; Martin Witzenrath; Konstantin Mayer; Norbert Weissmann; A Schell; Simone Rosseau; Werner Seeger; Friedrich Grimminger
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L496-502.
2000: Richard Schulz; S Mahmoudi; Katja Hattar; Ulf Sibelius; Horst Olschewski; Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):566-70.
2000: Annette Klemm; Thomas Tschernig; Leander Ermert; André Althoff; M Merkle; Andreas Gebert; Monika Ermert; Werner Seeger; Reinhard Pabst
Blockade of leucocyte function-associated antigen-1 (LFA-1) decreases lymphocyte trapping in the normal pulmonary vasculature: studies in the isolated buffer-perfused rat lung.
Clinical and experimental immunology 2000;121(2):375-83.
2000: Norbert Weissmann; Robert Voswinckel; A Tadic; T Hardebusch; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2000;23(2):222-7.
2000: Frank Rose; Ladislau Kiss; Friedrich Grimminger; Konstantin Mayer; Ulrich Grandel; Werner Seeger; E Bieniek; Ulf Sibelius
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L100-9.
2000: Simone Rosseau; P Hammerl; Ulrich A Maus; H D Walmrath; Hartwig Schütte; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L25-35.
2000: Frank Rose; K U Heuer; Ulf Sibelius; S Hombach-Klonisch; L Kiss; Werner Seeger; Friedrich Grimminger
Targeting lipopolysaccharides by the nontoxic polymyxin B nonapeptide sensitizes resistant Escherichia coli to the bactericidal effect of human neutrophils.
The Journal of infectious diseases 2000;182(1):191-9.
2000: Horst Olschewski; Werner Seeger
[Treatment of pulmonary artery hypertension].
Pneumologie (Stuttgart, Germany) 2000;54(6):222-4.
2000: Ulrich A Maus; Susanne Herold; Karl-Hermann Schlingensiepen; Reimar Schlingensiepen; T Dormayr; Simone Rosseau; Regina Maus; Werner Seeger; Jürgen Lohmeyer
Antisense oligomers for selective suppression of MCP-1 synthesis in human pulmonary endothelial cells.
Antisense & nucleic acid drug development 2000;10(3):185-93.
2000: Andreas Günther; P Mosavi; Clemens Ruppert; Sabine Heinemann; Bettina Temmesfeld; Hans-Georg Velcovsky; Harald Morr; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease.
Thrombosis and haemostasis 2000;83(6):853-60.
2000: Ladislau Kiss; Hartwig Schütte; Konstantin Mayer; Helmut Grimm; Winfried Padberg; Werner Seeger; Friedrich Grimminger
Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P450 products in the intact human lung vasculature.
American journal of respiratory and critical care medicine 2000;161(6):1917-23.
2000: Monika Ermert; M Merkle; R Mootz; Friedrich Grimminger; Werner Seeger; Leander Ermert
Endotoxin priming of the cyclooxygenase-2-thromboxane axis in isolated rat lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1195-203.
2000: Leander Ermert; Monika Ermert; M Merkle; M Goppelt-Struebe; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger
Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung.
The American journal of pathology 2000;156(4):1275-87.
2000: Leander Ermert; Monika Ermert; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger
In situ localization and regulation of thromboxane A(2) synthase in normal and LPS-primed lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L744-53.
2000: Horst Olschewski; Hossein A Ghofrani; Thomas Schmehl; J Winkler; Heinrike Wilkens; M M Höper; Jürgen Behr; F X Kleber; Werner Seeger
Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group.
Annals of internal medicine 2000;132(6):435-43.
2000: Ludger Fink; T Kinfe; Maria Magdalena Stein; Leander Ermert; Jörg Hänze; Wolfgang Kummer; Werner Seeger; Rainer M Bohle
Immunostaining and laser-assisted cell picking for mRNA analysis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(3):327-33.
2000: Andreas Günther; P Mosavi; Sabine Heinemann; Clemens Ruppert; Heidrun Muth; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Werner Seeger
Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):454-62.
2000: Friedrich Grimminger; Konstantin Mayer; Ladislau Kiss; Dieter Walmrath; Werner Seeger
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L268-75.
2000: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; Christian Schudt; Hermann Tenor; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
2000: Ulf Sibelius; Ulrich Grandel; Michael Buerke; D Mueller; Ladislau Kiss; H J Kraemer; Ruediger C Braun-Dullaeus; Werner Haberbosch; Werner Seeger; Friedrich Grimminger
Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation.
Circulation 2000;101(1):78-85.
2000: Rainer M Bohle; E Hartmann; T Kinfe; Leander Ermert; Werner Seeger; Ludger Fink
Cell type-specific mRNA quantitation in non-neoplastic tissues after laser-assisted cell picking.
Pathobiology : journal of immunopathology, molecular and cellular biology 2000;68(4-5):191-5.
2000: Ralph Theo Schermuly; Andreas Günther; Norbert Weissmann; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Dieter Walmrath
Differential impact of ultrasonically nebulized versus tracheal-instilled surfactant on ventilation-perfusion (VA/Q) mismatch in a model of acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):152-9.
2000: Simone Rosseau; J Selhorst; K Wiechmann; K Leissner; Ulrich A Maus; Konstantin Mayer; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Monocyte migration through the alveolar epithelial barrier: adhesion molecule mechanisms and impact of chemokines.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):427-35.
1999: Werner Seeger
[Pneumology. From the diagnosis of pulmonary functions to molecular medicine].
Deutsche medizinische Wochenschrift (1946) 1999;124(51-52):1566-9.
1999: Andreas Günther; Philipp Markart; M Kalinowski; Clemens Ruppert; Friedrich Grimminger; Werner Seeger
Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents. Kinetics of lysis and rescue of surface activity.
American journal of respiratory cell and molecular biology 1999;21(6):738-45.
1999: Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Christian Schudt; Dieter Walmrath
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Simone Rosseau; P Hammerl; Ulrich A Maus; Andreas Günther; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Surfactant protein A down-regulates proinflammatory cytokine production evoked by Candida albicans in human alveolar macrophages and monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4495-502.
1999: Gerd Hermle; Hartwig Schütte; Dieter Walmrath; Klaus K Geiger; Werner Seeger; Friedrich Grimminger
Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide.
American journal of respiratory and critical care medicine 1999;160(4):1179-87.
1999: Konstantin Mayer; Bettina Temmesfeld-Wollbrück; A Friedland; Horst Olschewski; M Reich; Werner Seeger; A F Grimminger
Severe microcirculatory abnormalities elicited by E. coli hemolysin in the rabbit ileum mucosa.
American journal of respiratory and critical care medicine 1999;160(4):1171-8.
1999: Andreas Günther; Reinhold Schmidt; F Nix; M Yabut-Perez; C Guth; Simone Rosseau; C Siebert; Friedrich Grimminger; Harald Morr; Hans-Georg Velcovsky; Werner Seeger
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(3):565-73.
1999: Frank Rose; K Zwick; Hossein A Ghofrani; Ulf Sibelius; Werner Seeger; Dieter Walmrath; Friedrich Grimminger
Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;160(3):846-51.
1999: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; B Temmesfeld-Wollbruck; Friedrich Grimminger; Werner Seeger
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.
American journal of respiratory and critical care medicine 1999;160(2):600-7.
1999: Friedrich Grimminger; Horst Olschewski; Werner Seeger
[Vasotropic therapy and artificial respiration for pulmonary hypertension].
Der Internist 1999;40(7):747-55.
1999: Horst Olschewski; Werner Seeger; Friedrich Grimminger
[Physiology and physiopathology of the pulmonary circulation].
Der Internist 1999;40(7):696-709.
1999: Jürgen Lohmeyer; J Friedrich; Friedrich Grimminger; Ulrich A Maus; R Tenter; Harald Morr; Hans-Georg Velcovsky; Werner Seeger; Simone Rosseau
Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases.
Clinical and experimental immunology 1999;116(2):340-6.
1999: Werner Seeger
[Pneumology].
Der Internist 1999;40(4):391-400.
1999: Ludger Fink; U Stahl; Leander Ermert; Wolfgang Kummer; Werner Seeger; Rainer M Bohle
Rat porphobilinogen deaminase gene: a pseudogene-free internal standard for laser-assisted cell picking.
BioTechniques 1999;26(3):510-6.
1999: Ulf Sibelius; E C Schulz; Frank Rose; Katja Hattar; T Jacobs; S Weiss; Trinad Chakraborty; Werner Seeger; Friedrich Grimminger
Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils.
Infection and immunity 1999;67(3):1125-30.
1999: Ulrich A Maus; Simone Rosseau; N Mandrakas; Reimar Schlingensiepen; Regina Maus; Heidrun Muth; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Cationic lipids employed for antisense oligodeoxynucleotide transport may inhibit vascular cell adhesion molecule-1 expression in human endothelial cells: a word of caution.
Antisense & nucleic acid drug development 1999;9(1):71-80.
1999: Norbert Weissmann; Robert Voswinckel; T Hardebusch; Simone Rosseau; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
The American journal of physiology 1999;276(1 Pt 1):L90-5.
1999: Andreas Günther; Reinhold Schmidt; Andreas Feustel; U Meier; Carolin Pucker; Monika Ermert; Werner Seeger
Surfactant subtype conversion is related to loss of surfactant apoprotein B and surface activity in large surfactant aggregates. Experimental and clinical studies.
American journal of respiratory and critical care medicine 1999;159(1):244-51.
1998: Helmut Grimm; Friedrich Grimminger; Stephan Korom; Werner Seeger
Use of fish oil to prevent graft rejection.
The Proceedings of the Nutrition Society 1998;57(4):577-85.
1998: Norbert Weissmann; Werner Seeger; Jörg Conzen; Ladislau Kiss; Friedrich Grimminger
Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs.
European journal of pharmacology 1998;356(2-3):231-7.
1998: Leander Ermert; Monika Ermert; André Althoff; M Merkle; Friedrich Grimminger; Werner Seeger
Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1309-14.
1998: Ladislau Kiss; E Bieniek; Norbert Weissmann; H Schutte; Ulf Sibelius; Andreas Gunther; J Bier; Konstantin Mayer; K Henneking; Winfried Padberg; Helmut Grimm; Werner Seeger; Friedrich Grimminger
Simultaneous analysis of 4- and 5-series lipoxygenase and cytochrome P450 products from different biological sources by reversed-phase high-performance liquid chromatographic technique.
Analytical biochemistry 1998;261(1):16-28.
1998: Franz-Xaver Glocker; Joachim K Krauss; Günther Deuschl; Werner Seeger; Carl Hermann Lücking
Hemifacial spasm due to posterior fossa tumors: the impact of tumor location on electrophysiological findings.
Clinical neurology and neurosurgery 1998;100(2):104-11.
1998: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; Werner Seeger
Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.
Intensive care medicine 1998;24(6):631-4.
1998: Norbert Weissmann; Friedrich Grimminger; Robert Voswinckel; Jörg Conzen; Werner Seeger
Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs.
The American journal of physiology 1998;274(5 Pt 1):L721-7.
1998: Bettina Temmesfeld-Wollbrück; A Szalay; Konstantin Mayer; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine.
American journal of respiratory and critical care medicine 1998;157(5 Pt 1):1586-92.
1998: Peter Mayser; U Mrowietz; P Arenberger; P Bartak; J Buchvald; E Christophers; S Jablonska; W Salmhofer; Wolf-Bernhard Schill; Hans-Joachim Krämer; E Schlotzer; Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial.
Journal of the American Academy of Dermatology 1998;38(4):539-47.
1998: Leander Ermert; Monika Ermert; M Goppelt-Struebe; Dieter Walmrath; Friedrich Grimminger; W Steudel; Hossein A Ghofrani; C Homberger; Hans-Rainer Duncker; Werner Seeger
Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs.
American journal of respiratory cell and molecular biology 1998;18(4):479-88.
1998: Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Clinical use of lipids to control inflammatory disease.
Current opinion in clinical nutrition and metabolic care 1998;1(2):179-84.
1998: Ulrich A Maus; Simone Rosseau; U Knies; Werner Seeger; Jürgen Lohmeyer
Expression of pro-inflammatory cytokines by flow-sorted alveolar macrophages in severe pneumonia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(3):534-41.
1998: Ulf Sibelius; Katja Hattar; A Schenkel; Thomas Noll; Elena Csernok; W L Gross; Werner-Johannes Mayet; Hans Michael Piper; Werner Seeger; Friedrich Grimminger
Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.
The Journal of experimental medicine 1998;187(4):497-503.
1998: Hartwig Schütte; Konstantin Mayer; Tobias Gessler; M Rühl; J Schlaudraff; H Burger; Werner Seeger; Friedrich Grimminger
Nitric oxide biosynthesis in an exotoxin-induced septic lung model: role of cNOS and impact on pulmonary hemodynamics.
American journal of respiratory and critical care medicine 1998;157(2):498-504.
1998: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension].
Pneumologie (Stuttgart, Germany) 1998;52(1):3-7.
1998: Hartwig Schütte; Gerd Hermle; Werner Seeger; Friedrich Grimminger
Vascular distension and continued ventilation are protective in lung ischemia/reperfusion.
American journal of respiratory and critical care medicine 1998;157(1):171-7.
1997: Hartwig Schütte; Simone Rosseau; R Czymek; Leander Ermert; Dieter Walmrath; Hans-Joachim Krämer; Werner Seeger; Friedrich Grimminger
Synergism between endotoxin priming and exotoxin challenge in provoking severe vascular leakage in rabbit lungs.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):819-24.
1997: Friedrich Grimminger; Frank Rose; Ulf Sibelius; M Meinhardt; Bernd Pötzsch; R Spriestersbach; Sucharit Bhakdi; Norbert Suttorp; Werner Seeger
Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1909-16.
1997: Ralph Theo Schermuly; Thomas Schmehl; Andreas Günther; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):445-53.
1997: Hartwig Schütte; Friedrich Grimminger; J Otterbein; R Spriestersbach; Konstantin Mayer; Dieter Walmrath; Werner Seeger
Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation.
The Journal of pharmacology and experimental therapeutics 1997;282(2):985-94.
1997: W Steudel; Hans-Joachim Krämer; D Degner; Simone Rosseau; Hartwig Schütte; Dieter Walmrath; Werner Seeger
Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(1):18-24.
1997: Friedrich Grimminger; Konstantin Mayer; Werner Seeger
[Is there a reliable immunotherapy in infection?].
Der Internist 1997;38(6):541-52.
1997: Dieter Walmrath; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[NO and alternative inhalational therapy approaches in pulmonary hypertension].
Der Internist 1997;38(5):453-60.
1997: Dieter Walmrath; Ralph Theo Schermuly; J Pilch; Friedrich Grimminger; Werner Seeger
Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(5):1084-92.
1997: Joachim K Krauss; Werner Seeger; Joseph Jankovic
Cervical dystonia associated with tumors of the posterior fossa.
Movement disorders : official journal of the Movement Disorder Society 1997;12(3):443-7.
1997: B Temmesfeld-Wollbrueck; CM Heinrichs; A Szalay; Werner Seeger
Granulomatous gastritis in Wegener's disease: differentiation from Crohn's disease supported by a positive test for antineutrophil antibodies.
Gut 1997;40(4):550-3.
1997: Bettina Temmesfeld-Wollbrück; A Szalay; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Advantage of buffered solutions or automated capnometry in air-filled balloons for use in gastric tonometry.
Intensive care medicine 1997;23(4):423-7.
1997: Ulrich A Maus; Simone Rosseau; Werner Seeger; Jürgen Lohmeyer
Separation of human alveolar macrophages by flow cytometry.
The American journal of physiology 1997;272(3 Pt 1):L566-71.
1997: Friedrich Grimminger; Konstantin Mayer; Ladislau Kiss; H Wahn; Dieter Walmrath; Werner Seeger
Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply.
American journal of respiratory cell and molecular biology 1997;16(3):317-24.
1997: Simone Rosseau; Andreas Guenther; Werner Seeger; Jürgen Lohmeyer
Phagocytosis of viable Candida albicans by alveolar macrophages: lack of opsonin function of surfactant protein A.
The Journal of infectious diseases 1997;175(2):421-8.
1997: Leander Ermert; Hans-Rainer Duncker; Hans Brückner; Friedrich Grimminger; T Hansen; R Rössig; K Aktories; Werner Seeger
Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(2):382-8.
1997: Friedrich Grimminger; H Wahn; Konstantin Mayer; Ladislau Kiss; Dieter Walmrath; Werner Seeger
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
American journal of respiratory and critical care medicine 1997;155(2):513-9.
1996: Ulf Sibelius; Trinad Chakraborty; B Krögel; J Wolf; Frank Rose; Reinhold Schmidt; Jürgen Wehland; Werner Seeger; Friedrich Grimminger
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4055-60.
1996: Hans-Joachim Krämer; J Stevens; Friedrich Grimminger; Werner Seeger
Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation.
Biochemical pharmacology 1996;52(8):1211-7.
1996: Friedrich Grimminger; Katja Hattar; C Papavassilis; B Temmesfeld; E Csernok; W L Gross; Werner Seeger; Ulf Sibelius
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
The Journal of experimental medicine 1996;184(4):1567-72.
1996: Hartwig Schütte; Jürgen Lohmeyer; Simone Rosseau; S Ziegler; C Siebert; H Kielisch; H Pralle; Friedrich Grimminger; Harald Morr; Werner Seeger
Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(9):1858-67.
1996: Joachim K Krauss; DW Droste; W Vach; JP Regel; M Orszagh; JJ Borremans; A Tietz; Werner Seeger
Cerebrospinal fluid shunting in idiopathic normal-pressure hydrocephalus of the elderly: effect of periventricular and deep white matter lesions.
Neurosurgery 1996;39(2):292-9; discussion 299-300.
1996: Dieter Walmrath; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Synergism of alveolar endotoxin "priming" and intravascular exotoxin challenge in lung injury.
American journal of respiratory and critical care medicine 1996;154(2 Pt 1):460-8.
1996: JJ Borremans; Joachim K Krauss; R V Fanardjian; Werner Seeger
Hemichorea-hemiballism associated with an ipsilateral intraventricular cyst after resection of a meningioma.
Parkinsonism & related disorders 1996;2(3):155-9.
1996: Dieter Walmrath; Andreas Günther; Hossein A Ghofrani; Ralph Theo Schermuly; T Schneider; Friedrich Grimminger; Werner Seeger
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis.
American journal of respiratory and critical care medicine 1996;154(1):57-62.
1996: Juergen Bux; F Becker; Werner Seeger; D Kilpatrick; J Chapman; A Waters
Transfusion-related acute lung injury due to HLA-A2-specific antibodies in recipient and NB1-specific antibodies in donor blood.
British journal of haematology 1996;93(3):707-13.
1996: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; A Ghofrani; Friedrich Grimminger; Werner Seeger
Aerosolized prostacyclin and iloprost in severe pulmonary hypertension.
Annals of internal medicine 1996;124(9):820-4.
1996: Dieter Walmrath; T Schneider; Ralph Theo Schermuly; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1996;153(3):991-6.
1996: Ulf Sibelius; Frank Rose; Trinad Chakraborty; Ayub Darji; Jürgen Wehland; S Weiss; Werner Seeger; Friedrich Grimminger
Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.
Infection and immunity 1996;64(2):674-6.
1996: Friedrich Grimminger; Helmut Grimm; D Führer; C Papavassilis; G Lindemann; C Blecher; Konstantin Mayer; F Tabesch; Hans-Joachim Krämer; J Stevens; Werner Seeger
Omega-3 lipid infusion in a heart allotransplant model. Shift in fatty acid and lipid mediator profiles and prolongation of transplant survival.
Circulation 1996;93(2):365-71.
1996: T Schmehl; J Gebhart; Hartwig Schütte; A Scharmann; Werner Seeger
On-line laser-photometric monitoring of aerosol deposition in ventilated rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;80(1):351-6.
1996: Leander Ermert; R Rössig; T Hansen; Hartwig Schütte; Klaus Aktories; Werner Seeger
Differential role of actin in lung endothelial and epithelial barrier properties in perfused rabbit lungs.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(1):93-9.
1996: Hossein A Ghofrani; Simone Rosseau; Dieter Walmrath; W Kaddus; A Kramer; Friedrich Grimminger; Jürgen Lohmeyer; Werner Seeger
Compartmentalized lung cytokine release in response to intravascular and alveolar endotoxin challenge.
The American journal of physiology 1996;270(1 Pt 1):L62-8.
1996: Helmut Bertalanffy; Joachim M Gilsbach; Lothar Mayfrank; HM Klein; T Kawase; Werner Seeger
Microsurgical management of ventral and ventrolateral foramen magnum meningiomas.
Acta neurochirurgica. Supplement 1996;65():82-5.
1996: Andreas Günther; C Siebert; Reinhold Schmidt; S Ziegler; Friedrich Grimminger; M Yabut; B Temmesfeld; Dieter Walmrath; Harald Morr; Werner Seeger
Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema.
American journal of respiratory and critical care medicine 1996;153(1):176-84.
1995: Joachim K Krauss; Ajay K Wakhloo; F Nobbe; R Tränkle; F Mundinger; Werner Seeger
Lesion of dentatothalamic pathways in severe post-traumatic tremor.
Neurological research 1995;17(6):409-16.
1995: Werner Seeger; Dieter Walmrath; Friedrich Grimminger
[New supportive therapy measures in acute lung failure].
Der Internist 1995;36(12):1139-49.
1995: Andreas Günther; M Kalinowski; Simone Rosseau; Werner Seeger
Surfactant incorporation markedly alters mechanical properties of a fibrin clot.
American journal of respiratory cell and molecular biology 1995;13(6):712-8.
1995: Hans-Joachim Krämer; Reinhold Schmidt; Andreas Günther; G Becker; Y Suzuki; Werner Seeger
ELISA technique for quantification of surfactant protein B (SP-B) in bronchoalveolar lavage fluid.
American journal of respiratory and critical care medicine 1995;152(5 Pt 1):1540-4.
1995: Werner Seeger; Dieter Walmrath; Friedrich Grimminger
[ARDS. Intensive therapy of acute lung failure].
Der Internist 1995;36(8):785-801.
1995: Werner Seeger; T Hansen; R Rössig; T Schmehl; Hartwig Schütte; Hans-Joachim Krämer; Dieter Walmrath; Norbert Weissmann; Friedrich Grimminger; Norbert Suttorp
Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition.
Microvascular research 1995;50(1):1-17.
1995: Friedrich Grimminger; H Wahn; H J Kramer; J Stevens; Konstantin Mayer; Dieter Walmrath; Werner Seeger
Differential influence of arachidonic vs. eicosapentaenoic acid on experimental pulmonary hypertension.
The American journal of physiology 1995;268(6 Pt 2):H2252-9.
1995: Leander Ermert; Hans Brückner; Dieter Walmrath; Friedrich Grimminger; Klaus Aktories; Norbert Suttorp; Hans-Rainer Duncker; Werner Seeger
Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L753-61.
1995: Friedrich Grimminger; Norbert Weissmann; R Spriestersbach; E Becker; Simone Rosseau; Werner Seeger
Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L747-52.
1995: Norbert Weissmann; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Respiration physiology 1995;100(2):159-69.
1995: Werner Seeger; H G Lasch
[Respiratory insufficiency].
Der Internist 1995;36(4):318-26.
1995: Friedrich Grimminger; R Spriestersbach; Norbert Weissmann; Dieter Walmrath; Werner Seeger
Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1509-15.
1995: R Spriestersbach; Friedrich Grimminger; Norbert Weissmann; Dieter Walmrath; Werner Seeger
On-line measurement of nitric oxide generation in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1502-8.
1995: Dieter Walmrath; T Schneider; J Pilch; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):724-30.
1995: Jan Schmolling; Werner Seeger; A Jensen
Liquid movements in ventilated and perfused isolated lungs of fetal sheep at 0.87, 0.90, and 0.95 of term.
Reproduction, fertility, and development 1995;7(5):1345-50.
1995: Joachim K Krauss; DW Droste; Martin Bohus; JP Regel; R Scheremet; Dieter Riemann; Werner Seeger
The relation of intracranial pressure B-waves to different sleep stages in patients with suspected normal pressure hydrocephalus.
Acta neurochirurgica 1995;136(3-4):195-203.
1995: Ulrich Sure; Helmut Bertalanffy; S Isenmann; Sebastian Brandner; W J Berghorn; Werner Seeger; Adriano Aguzzi
Secondary manifestation of medulloblastoma: metastases and local recurrences in 66 patients.
Acta neurochirurgica 1995;136(3-4):117-26.
1995: Joachim K Krauss; T Paduch; F Mundinger; Werner Seeger
Parkinsonism and rest tremor secondary to supratentorial tumours sparing the basal ganglia.
Acta neurochirurgica 1995;133(1-2):22-9.
1995: Ulrich Sure; W J Berghorn; Helmut Bertalanffy; T Wakabayashi; J Yoshida; K Sugita; Werner Seeger
Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute.
Acta neurochirurgica 1995;132(1-3):59-65.
1995: Bettina Temmesfeld-Wollbrück; Dieter Walmrath; Friedrich Grimminger; Werner Seeger
Prevention and therapy of the adult respiratory distress syndrome.
Lung 1995;173(3):139-64.
1994: Andreas Günther; M Kalinowski; A Elssner; Werner Seeger
Clot-embedded natural surfactant: kinetics of fibrinolysis and surface activity.
The American journal of physiology 1994;267(5 Pt 1):L618-24.
1994: Dieter Walmrath; Hossein A Ghofrani; Simone Rosseau; Hartwig Schütte; A Cramer; W Kaddus; Friedrich Grimminger; Sucharit Bhakdi; Werner Seeger
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
The Journal of experimental medicine 1994;180(4):1437-43.
1994: Simone Rosseau; Werner Seeger; H Pralle; Jürgen Lohmeyer
Phagocytosis of viable Candida albicans by alveolar macrophages: flow cytometric quantification.
The American journal of physiology 1994;267(2 Pt 1):L211-7.
1994: Leander Ermert; Hans-Rainer Duncker; Simone Rosseau; Hartwig Schütte; Werner Seeger
Morphometric analysis of pulmonary intracapillary leukocyte pools in ex vivo-perfused rabbit lungs.
The American journal of physiology 1994;267(1 Pt 1):L64-70.
1994: Jürgen Lohmeyer; J Friedrich; Simone Rosseau; H Pralle; Werner Seeger
Multiparameter flow cytometric analysis of inflammatory cells contained in bronchoalveolar lavage fluid.
Journal of immunological methods 1994;172(1):59-70.
1994: Dieter Walmrath; J Pilch; M Scharmann; Friedrich Grimminger; Werner Seeger
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1020-30.
1994: Werner Seeger; Dieter Walmrath; Friedrich Grimminger; Simone Rosseau; Hartwig Schütte; Hans-Joachim Krämer; Leander Ermert; Ladislau Kiss
Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs.
Methods in enzymology 1994;233():549-84.
1993: Dieter Walmrath; M Griebner; B Kolb; Friedrich Grimminger; C Galanos; U Schade; Werner Seeger
Endotoxin primes perfused rabbit lungs for enhanced vasoconstrictor response to staphylococcal alpha-toxin.
The American review of respiratory disease 1993;148(5):1179-86.
1993: Dieter Walmrath; T Schneider; J Pilch; Friedrich Grimminger; Werner Seeger
Aerosolised prostacyclin in adult respiratory distress syndrome.
Lancet 1993;342(8877):961-2.
1993: Bettina Temmesfeld-Wollbrück; Harald Morr; N Suttorp; M Altmannsberger; Werner Seeger
[Three cases of a fulminant course of idiopathic pulmonary fibrosis (Hamman-Rich syndrome)].
Pneumologie (Stuttgart, Germany) 1993;47(10):573-8.
1993: Friedrich Grimminger; Konstantin Mayer; Hans-Joachim Krämer; J Stevens; Dieter Walmrath; Werner Seeger
Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2-versus 3-series prostanoid generation.
The Journal of pharmacology and experimental therapeutics 1993;267(1):259-65.
1993: Werner Seeger; C Grube; Andreas Günther
Proteolytic cleavage of fibrinogen: amplification of its surfactant inhibitory capacity.
American journal of respiratory cell and molecular biology 1993;9(3):239-47.
1993: Andreas Günther; H Bleyl; Werner Seeger
Apoprotein-based synthetic surfactants inhibit plasmic cleavage of fibrinogen in vitro.
The American journal of physiology 1993;265(2 Pt 1):L186-92.
1993: Werner Seeger; A Elssner; Andreas Günther; Hans-Joachim Krämer; H O Kalinowski
Lung surfactant phospholipids associate with polymerizing fibrin: loss of surface activity.
American journal of respiratory cell and molecular biology 1993;9(2):213-20.
1993: Werner Seeger; C Grube; Andreas Günther; Reinhold Schmidt
Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(7):971-7.
1993: Joachim K Krauss; Ajay K Wakhloo; R Scheremet; Werner Seeger
Facial myokymia and spastic paretic facial contracture as the result of anaplastic pontocerebellar glioma.
Neurosurgery 1993;32(6):1031-4.
1993: H Bertalanffy; S Bechtel; Werner Seeger
Regional exposure of cerebral convexity lesions.
Neurochirurgia 1993;36(3):81-6.
1993: Werner Seeger
[Prevention of acute lung failure (ARDS)].
Medizinische Klinik (Munich, Germany : 1983) 1993;88(4):231-46.
1993: Dieter Walmrath; M Scharmann; R König; J Pilch; Friedrich Grimminger; Werner Seeger
Staphylococcal alpha-toxin induced ventilation-perfusion mismatch in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1972-80.
1993: Joachim K Krauss; H Bertalanffy; K Schwechheimer; A Müller; Werner Seeger
Ventral brain stem schwannoma at the entry zone of the hypoglossal nerve.
Neurochirurgia 1993;36(2):66-9.
1993: Werner Seeger; Andreas Günther; H D Walmrath; Friedrich Grimminger; H G Lasch
Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects.
The Clinical investigator 1993;71(3):177-90.
1993: Leander Ermert; Werner Seeger; Hans-Rainer Duncker
Computer-assisted morphometry of the intracapillary leukocyte pool in the rabbit lung.
Cell and tissue research 1993;271(3):469-76.
1992: Werner Seeger; Friedrich Grimminger; Dieter Walmrath
[ARDS: possible role of bacterial exotoxin].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 1992;27(5):310-4.
1992: H Bertalanffy; G Kühn; R Scheremet; Werner Seeger
Indications for surgery and prognosis in patients with cerebral cavernous angiomas.
Neurologia medico-chirurgica 1992;32(9):659-66.
1992: Friedrich Grimminger; U Dürr; Werner Seeger
Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply.
Molecular pharmacology 1992;41(4):757-66.
1992: Werner Seeger; Andreas Günther; C Thede
Differential sensitivity to fibrinogen inhibition of SP-C- vs. SP-B-based surfactants.
The American journal of physiology 1992;262(3 Pt 1):L286-91.
1992: Leander Ermert; S Rousseau; Hartwig Schütte; R G Birkemeyer; Friedrich Grimminger; Sucharit Bhakdi; Hans-Rainer Duncker; Werner Seeger
Induction of severe vascular leakage by low doses of Escherichia coli hemolysin in perfused rabbit lungs.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):362-9.
1992: Friedrich Grimminger; I von Kürten; Dieter Walmrath; Werner Seeger
Type II alveolar epithelial eicosanoid metabolism: predominance of cyclooxygenase pathways and transcellular lipoxygenase metabolism in co-culture with neutrophils.
American journal of respiratory cell and molecular biology 1992;6(1):9-16.
1992: G Laborde; Joachim M Gilsbach; Albrecht Harders; Werner Seeger
Experience with the infratentorial supracerebellar approach in lesions of the quadrigeminal region, posterior third ventricle, culmen cerebelli, and cerebellar peduncle.
Acta neurochirurgica 1992;114(3-4):135-8.
1992: Dieter Walmrath; R König; C Ernst; Hans Brückner; Friedrich Grimminger; Werner Seeger
Ventilation-perfusion relationships in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(1):374-82.
1991: H Bertalanffy; Werner Seeger
The dorsolateral, suboccipital, transcondylar approach to the lower clivus and anterior portion of the craniocervical junction.
Neurosurgery 1991;29(6):815-21.
1991: Dieter Walmrath; U Schneider; B Kreusler; Friedrich Grimminger; M Ennis; Werner Seeger
Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2499-506.
1991: Friedrich Grimminger; Ulf Sibelius; Sucharit Bhakdi; Norbert Suttorp; Werner Seeger
Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils.
The Journal of clinical investigation 1991;88(5):1531-9.
1991: Friedrich Grimminger; Ulf Sibelius; Klaus Aktories; Ingo Just; Werner Seeger
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
The Journal of biological chemistry 1991;266(29):19276-82.
1991: Hartwig Schütte; Simone Rosseau; Dieter Walmrath; Friedrich Grimminger; C Ernst; Werner Seeger
Neutrophil passage through isolated perfused rabbit lungs.
The American journal of physiology 1991;261(4 Pt 2):H1317-23.
1991: Friedrich Grimminger; Ulf Sibelius; Klaus Aktories; Norbert Suttorp; Werner Seeger
Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils.
Molecular pharmacology 1991;40(4):563-71.
1991: Friedrich Grimminger; C Scholz; Sucharit Bhakdi; Werner Seeger
Subhemolytic doses of Escherichia coli hemolysin evoke large quantities of lipoxygenase products in human neutrophils.
The Journal of biological chemistry 1991;266(22):14262-9.
1991: Friedrich Grimminger; Ulf Sibelius; Werner Seeger
Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism.
The American journal of physiology 1991;261(2 Pt 1):L195-203.
1991: Norbert Suttorp; M Polley; J Seybold; Hans-Joachim Schnittler; Werner Seeger; Friedrich Grimminger; Klaus Aktories
Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.
The Journal of clinical investigation 1991;87(5):1575-84.
1991: Werner Seeger; R Obernitz; M Thomas; Dieter Walmrath; N Suttorn; I B Holland; Friedrich Grimminger; B Eberspächer; F Hugo; Sucharit Bhakdi
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
The American review of respiratory disease 1991;143(4 Pt 1):797-805.
1991: Friedrich Grimminger; B Kreusler; U Schneider; E von Witzleben; Dieter Walmrath; Juergen Neppert; Werner Seeger
Human leukoagglutinating antibody evokes cooperative leukotriene synthesis in pulmonary microvasculature. Model of transfusion-related acute lung injury.
Circulation research 1991;68(2):503-12.
1991: Friedrich Grimminger; Dieter Walmrath; H Walter; F Lutz; Werner Seeger
Induction of vascular injury by Pseudomonas aeruginosa cytotoxin in rabbit lungs is associated with the generation of different leukotrienes and hydroxyeicosatetraenoic acids.
The Journal of infectious diseases 1991;163(2):362-70.
1991: Werner Seeger; C Thede; Andreas Günther; C Grube
Surface properties and sensitivity to protein-inhibition of a recombinant apoprotein C-based phospholipid mixture in vitro--comparison to natural surfactant.
Biochimica et biophysica acta 1991;1081(1):45-52.
1991: H Bertalanffy; Joachim M Gilsbach; H R Eggert; Werner Seeger
Microsurgery of deep-seated cavernous angiomas: report of 26 cases.
Acta neurochirurgica 1991;108(3-4):91-9.
1991: Werner Seeger; J Hübel; K Klapettek; U Pison; Udo Obertacke; T Joka; L Roka
Procoagulant activity in bronchoalveolar lavage of severely traumatized patients--relation to the development of acute respiratory distress.
Thrombosis research 1991;61(1):53-64.
1991: J de Vries; J Gilsbach; Werner Seeger
Technical improvements in the lateral suboccipital approach for neurovascular decompression of the trigeminal and facial nerves.
Acta neurochirurgica 1991;111(1-2):64-7.
1991: Werner Seeger; Friedrich Grimminger; M Barden; G Becker; Jürgen Lohmeyer; D Heinrich; H G Lasch
Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema.
Intensive care medicine 1991;17(1):1-6.
1990: Norbert Suttorp; B Flöer; Hans-Joachim Schnittler; Werner Seeger; Sucharit Bhakdi
Effects of Escherichia coli hemolysin on endothelial cell function.
Infection and immunity 1990;58(11):3796-801.
1990: Werner Seeger; U Schneider; B Kreusler; E von Witzleben; Dieter Walmrath; Friedrich Grimminger; Juergen Neppert
Reproduction of transfusion-related acute lung injury in an ex vivo lung model.
Blood 1990;76(7):1438-44.
1990: Friedrich Grimminger; M Thomas; R Obernitz; Dieter Walmrath; Sucharit Bhakdi; Werner Seeger
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
The Journal of experimental medicine 1990;172(4):1115-25.
1990: Werner Seeger; R G Birkemeyer; Leander Ermert; Norbert Suttorp; Sucharit Bhakdi; Hans-Rainer Duncker
Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs.
Laboratory investigation; a journal of technical methods and pathology 1990;63(3):341-9.
1990: Friedrich Grimminger; Dieter Walmrath; R G Birkemeyer; Sucharit Bhakdi; Werner Seeger
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Infection and immunity 1990;58(8):2659-63.
1990: Friedrich Grimminger; B Kreusler; U Schneider; G Becker; Werner Seeger
Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1866-72.
1990: Werner Seeger; U Pison; R Buchhorn; Udo Obertacke; T Joka
Surfactant abnormalities and adult respiratory failure.
Lung 1990;168 Suppl():891-902.
1989: Norbert Suttorp; T Fuchs; Werner Seeger; A Wilke; D Drenckhahn
Role of Ca2+ and Mg2+ for endothelial permeability of water and albumin in vitro.
Laboratory investigation; a journal of technical methods and pathology 1989;61(2):183-91.
1989: Werner Seeger; H Walter; Norbert Suttorp; M Muhly; Sucharit Bhakdi
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs.
The Journal of clinical investigation 1989;84(1):220-7.
1989: Werner Seeger; H Walter; H Neuhof; Norbert Suttorp; Sucharit Bhakdi
Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs.
Progress in clinical and biological research 1989;308():67-72.
1989: Werner Seeger; R Hartmann; H Neuhof; Sucharit Bhakdi
In-situ complement activation, pulmonary hypertension and vascular leakage in rabbit lungs--the role of the terminal complement complex.
Progress in clinical and biological research 1989;308():283-9.
1989: S M Chiou; H R Eggert; G Laborde; Werner Seeger
Microsurgical unilateral approaches for spinal tumour surgery: eight years' experience in 256 primary operated patients.
Acta neurochirurgica 1989;100(3-4):127-33.
1989: Norbert Suttorp; Werner Seeger; H Neuhof
Stimulation of arachidonate metabolism by endotoxin and the terminal complement complex C5b-8.
Progress in clinical and biological research 1989;301():217-21.
1989: Norbert Suttorp; Werner Seeger; H Neuhof
Effects of bacterial exo- and endotoxins on endothelial arachidonate metabolism.
Progress in clinical and biological research 1989;308():119-25.
1989: H Neuhof; C Hoffmann; Werner Seeger; Norbert Suttorp; H Fritz
Proteases as mediators of pulmonary vascular permeability.
Progress in clinical and biological research 1989;308():305-14.
1989: Norbert Suttorp; T Hessz; T Fuchs; Werner Seeger; D Drenckhahn; H Neuhof
Effects of bacterial toxins and calcium-ionophores on endothelial permeability in vitro.
Progress in clinical and biological research 1989;308():127-31.
1989: Werner Seeger; R Hartmann; H Neuhoff; Sucharit Bhakdi
Local complement activation, thromboxane-mediated vasoconstriction, and vascular leakage in isolated lungs. Role of the terminal complement sequence.
The American review of respiratory disease 1989;139(1):88-99.
1988: Friedrich Grimminger; M Menger; G Becker; Werner Seeger
Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer.
Blood 1988;72(5):1687-92.
1988: Friedrich Grimminger; G Becker; Werner Seeger
High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(7):2431-6.
1988: Norbert Suttorp; T Hessz; Werner Seeger; A Wilke; R Koob; F Lutz; D Drenckhahn
Bacterial exotoxins and endothelial permeability for water and albumin in vitro.
The American journal of physiology 1988;255(3 Pt 1):C368-76.
1988: Werner Seeger; U Moser; L Roka
Effects of alpha-tocopherol, its carboxylic acid chromane compound and two novel antioxidant isoflavanones on prostaglandin H synthase activity and autodeactivation.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(1):74-81.
1988: Werner Seeger; N E Remy; H Neuhof
A highly sensitive gas chromatographic method does not detect exhalation of volatile hydrocarbons from isolated ventilated lungs under massive peroxidative stress.
Experimental lung research 1988;14(3):387-401.
1988: Werner Seeger; H Neuhof; J Hall; L Roka
Pulmonary vasoconstrictor response to soluble fibrin in isolated lungs: possible role of thromboxane generation.
Circulation research 1988;62(4):651-9.
1987: Werner Seeger; M Menger; Dieter Walmrath; G Becker; Friedrich Grimminger; H Neuhof
Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs.
The American review of respiratory disease 1987;136(4):964-72.
1987: Werner Seeger; H G Lasch
Septic lung.
Reviews of infectious diseases 1987;9 Suppl 5():S570-9.
1987: Werner Seeger; A Ziegler; H R Wolf
Serum alpha-tocopherol levels after high-dose enteral vitamin E administration in patients with acute respiratory failure.
Intensive care medicine 1987;13(6):395-400.
1986: H Neuhof; Werner Seeger; H R Wolf
Generation of mediators by limited proteolysis during blood coagulation and fibrinolysis--its pathogenetic role in the adult respiratory distress syndrome (ARDS).
Resuscitation 1986;14(1-2):23-32.
1985: Werner Seeger; C Ernst; D Walmrath; H Neuhof; L Roka
Influence of the thromboxane antagonist BM 13.177 on the arachidonic acid-induced increase in pulmonary vascular resistance and permeability in rabbit lungs.
Thrombosis research 1985;40(6):793-805.
1985: Werner Seeger; H Lepper; H R Wolf; H Neuhof
Alteration of alveolar surfactant function after exposure to oxidative stress and to oxygenated and native arachidonic acid in vitro.
Biochimica et biophysica acta 1985;835(1):58-67.
1985: Werner Seeger; G Stöhr; H R Wolf; H Neuhof
Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;58(2):326-38.
1983: Werner Seeger; H R Wolf; H Neuhof
[Disorder of alveolar surface tension in relation to the development of edema in isolated rabbit lungs].
Praxis und Klinik der Pneumologie 1983;37 Suppl 1():753-6.
1983: Werner Seeger; H R Wolf; H Neuhof; L Ròka
[Arachidonic acid metabolites as mediators of an increase in resistance and a barrier disorder in pulmonary microcirculation].
Praxis und Klinik der Pneumologie 1983;37 Suppl 1():728-31.
1983: H R Eggert; R Scheremet; Werner Seeger; J Gaitzsch
Unilateral microsurgical approaches to extramedullary spinal tumours. Operative technique and results.
Acta neurochirurgica 1983;67(3-4):245-53.
1983: Werner Seeger; H R Wolf; G Stähler; H Neuhof
Alteration of pressure-volume characteristics due to different types of edema induction in isolated rabbit lungs.
Respiration; international review of thoracic diseases 1983;44(4):273-81.
1983: Werner Seeger; H Neuhof; E Graubert; H Wolf; L Roka
Comparative influence of the Ca-ionophore A 23187, bradykinin, kallidin and eledoisin on the rabbit pulmonary vasculature with special reference to arachidonate metabolism.
Advances in experimental medicine and biology 1983;156():533-51.
1983: Werner Seeger; H R Wolf; H Neuhof; L Roka
Release and oxygenation of arachidonic acid: nonspecific triggering and pathophysiological consequences in isolated rabbit lungs.
Advances in prostaglandin, thromboxane, and leukotriene research 1983;12():99-105.
1983: Werner Seeger; H Wolf; E Graubert; U Moser; H Neuhof; L Roka
Influence of aprotinin and gabexate mesilate on arachidonic acid release by the Ca-ionophore A 23187 in the lung.
Advances in experimental medicine and biology 1983;156():553-67.
1982: H Neuhof; Werner Seeger; H Wolf; L Róka; H G Lasch
[Consumptive coagulopathy and lung function].
Der Internist 1982;23(8):457-62.
1982: Werner Seeger; H Wolf; G Stähler; H Neuhof; L Róka
Influence of tocopherol, its chromane compound, phytyl chains and superoxide dismutase on increased vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lung.
Prostaglandins 1982;23(2):175-84.
1982: Werner Seeger; H Wolf; G Stähler; H Neuhof; L Róka
Increased pulmonary vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lungs.
Prostaglandins 1982;23(2):157-73.
1981: Werner Seeger; H Wolf; G Stähler; H Neuhof; L Róka
[Increase of pulmonary vascular resistance and permeability due to the metabolism of free arachidonic acid (author's transl)].
Klinische Wochenschrift 1981;59(9):459-61.
1981: H Wolf; Werner Seeger; G Stähler; H Neuhof; L Róka
[The antioxidative chromane structure of alpha-tocopherol protects against the consequences of arachidonic acid release in the pulmonary vascular bed (author's transl)].
Klinische Wochenschrift 1981;59(9):463-5.