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Frank Seela

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TOP 3
Sachin A Ingale; Frank Seela
Stepwise click functionalization of DNA through a bifunctional azide with a chelating and a nonchelating azido group.
Hui Mei; Simone Budow; Frank Seela
Construction and assembly of chimeric DNA: oligonucleotide hybrid molecules composed of parallel or antiparallel duplexes and tetrameric i-motifs.
Sachin A Ingale; Frank Seela
A ratiometric fluorescent on-off Zn2+ chemosensor based on a tripropargylamine pyrene azide click adduct.

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All Publications

2013: Sachin A Ingale; Frank Seela
Stepwise click functionalization of DNA through a bifunctional azide with a chelating and a nonchelating azido group.
The Journal of organic chemistry 2013;78(7):3394-9.
2012: Hui Mei; Simone Budow; Frank Seela
Construction and assembly of chimeric DNA: oligonucleotide hybrid molecules composed of parallel or antiparallel duplexes and tetrameric i-motifs.
Biomacromolecules 2012;13(12):4196-204.
2012: Sachin A Ingale; Frank Seela
A ratiometric fluorescent on-off Zn2+ chemosensor based on a tripropargylamine pyrene azide click adduct.
The Journal of organic chemistry 2012;77(20):9352-6.
2012: Frank Seela; Hai Xiong; Simone Budow; Henning Eickmeier; Hui Mei; Hans Reuter
5-Ethynyl-2'-deoxycytidine: a DNA building block with a 'clickable' side chain.
Acta crystallographica. Section C, Crystal structure communications 2012;68(Pt 10):o395-8.
2012: Xin Ming; Frank Seela
A nucleobase-discriminating pyrrolo-dC click adduct designed for DNA fluorescence mismatch sensing.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(31):9590-600.
2012: Suresh S Pujari; Frank Seela
Cross-linked DNA: propargylated ribonucleosides as "click" ligation sites for bifunctional azides.
The Journal of organic chemistry 2012;77(9):4460-5.
2012: Hai Xiong; Peter Leonard; Frank Seela
Construction and assembly of branched Y-shaped DNA: "click" chemistry performed on dendronized 8-aza-7-deazaguanine oligonucleotides.
Bioconjugate chemistry 2012;23(4):856-70.
2012: Dorith Wunnicke; Ping Ding; Frank Seela; Heinz-Jürgen Steinhoff
Site-directed spin labeling of DNA reveals mismatch-induced nanometer distance changes between flanking nucleotides.
The journal of physical chemistry. B 2012;116(14):4118-23.
2012: Frank Seela; Hai Xiong; Simone Budow; Henning Eickmeier; Hans Reuter
A 2'-deoxycytidine long-linker click adduct forming two conformers in the asymmetric unit.
Acta crystallographica. Section C, Crystal structure communications 2012;68(Pt 4):o174-8.
2012: Xin Ming; Simone Budow; Ping Ding; Peter Leonard; Frank Seela
Parallel-stranded DNA: enhancing duplex stability by the 'G-clamp' and a pyrrolo-dC derivative.
Organic & biomolecular chemistry 2012;10(9):1861-9.
2011: Hai Xiong; Frank Seela
Stepwise "click" chemistry for the template independent construction of a broad variety of cross-linked oligonucleotides: influence of linker length, position, and linking number on DNA duplex stability.
The Journal of organic chemistry 2011;76(14):5584-97.
2011: Frank Seela; Ping Ding; Simone Budow
DNA gold nanoparticle conjugates incorporating thiooxonucleosides: 7-deaza-6-thio-2'-deoxyguanosine as gold surface anchor.
Bioconjugate chemistry 2011;22(4):794-807.
2011: Frank Seela; Ping Ding; Peter Leonard; Henning Eickmeier; Hans Reuter
1,N6-etheno-2'-deoxytubercidin hemihydrate.
Acta crystallographica. Section C, Crystal structure communications 2011;67(Pt 3):o111-4.
2010: Ping Ding; Dorith Wunnicke; Heinz-Jürgen Steinhoff; Frank Seela
Site-directed spin-labeling of DNA by the azide-alkyne 'click' reaction: nanometer distance measurements on 7-deaza-2'-deoxyadenosine and 2'-deoxyuridine nitroxide conjugates spatially separated or linked to a 'dA-dT' base pair.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(48):14385-96.
2010: Suresh S Pujari; Hai Xiong; Frank Seela
Cross-linked DNA generated by "bis-click" reactions with bis-functional azides: site independent ligation of oligonucleotides via nucleobase alkynyl chains.
The Journal of organic chemistry 2010;75(24):8693-6.
2010: Guangyan Qing; Hai Xiong; Frank Seela; Taolei Sun
Spatially controlled DNA nanopatterns by "click" chemistry using oligonucleotides with different anchoring sites.
Journal of the American Chemical Society 2010;132(43):15228-32.
2010: Dawei Jiang; Yang He; Simone Budow; Zygmunt Kazimierczuk; Henning Eickmeier; Hans Reuter; Frank Seela
7-Amino-1-(2-deoxy-β-erythro-pentofuranosyl)-1H-1,2,3-triazolo[4,5-d]pyrimidine: an 8-azaadenine nucleoside with the nucleobase in a syn conformation.
Acta crystallographica. Section C, Crystal structure communications 2010;66(Pt 11):o561-4.
2010: Xin Ming; Frank Seela
Efficient synthesis of the tRNA nucleoside preQ0, 7-cyano-7-deazaguanosine, via microwave-assisted iodo→carbonitrile exchange.
Chemistry & biodiversity 2010;7(10):2616-21.
2010: Frank Seela; Suresh S Pujari
Azide-alkyne "click" conjugation of 8-aza-7-deazaadenine-DNA: synthesis, duplex stability, and fluorogenic dye labeling.
Bioconjugate chemistry 2010;21(9):1629-41.
2010: Simone Budow; Frank Seela
2-azapurine nucleosides: synthesis, properties, and base pairing of oligonucleotides.
Chemistry & biodiversity 2010;7(9):2145-90.
2010: Frank Seela; Dawei Jiang; Simone Budow
Triplexes with 8-Aza-2'-deoxyisoguanosine replacing protonated dC: probing third strand stability with a fluorescent nucleobase targeting duplex DNA.
Chembiochem : a European journal of chemical biology 2010;11(10):1443-50.
2010: Dawei Jiang; Simone Budow; Virginie Glaçon; Henning Eickmeier; Hans Reuter; Yang He; Frank Seela
2-Amino-8-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)imidazo[1,2-a][1,3,5]triazin-4(8H)-one monohydrate, a 2'-deoxyguanosine analogue with an altered Watson-Crick recognition site.
Acta crystallographica. Section C, Crystal structure communications 2010;66(Pt 4):o194-7.
2010: Dawei Jiang; Frank Seela
Oligonucleotide duplexes and multistrand assemblies with 8-aza-2'-deoxyisoguanosine: a fluorescent isoG(d) shape mimic expanding the genetic alphabet and forming ionophores.
Journal of the American Chemical Society 2010;132(11):4016-24.
2010: Frank Seela; Sachin A Ingale
"Double click" reaction on 7-deazaguanine DNA: synthesis and excimer fluorescence of nucleosides and oligonucleotides with branched side chains decorated with proximal pyrenes.
The Journal of organic chemistry 2010;75(2):284-95.
2009: Simone Budow; Henning Eickmeier; Hans Reuter; Frank Seela
2'-Deoxy-5-propynyluridine: a nucleoside with two conformations in the asymmetric unit.
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 12):o645-8.
2009: Frank Seela; Dawei Jiang; Kuiying Xu
8-Aza-2'-deoxyguanosine: base pairing, mismatch discrimination and nucleobase anion fluorescence sensing in single-stranded and duplex DNA.
Organic & biomolecular chemistry 2009;7(17):3463-73.
2009: Frank Seela; Sachin A Ingale; Peter Leonard; Henning Eickmeier; Hans Reuter
A toyocamycin analogue with the sugar moiety in a syn conformation.
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 9):o431-4.
2009: Peter Leonard; Sachin A Ingale; Ping Ding; Xin Ming; Frank Seela
Studies on the glycosylation of pyrrolo[2,3-d] pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose: the formation of regioisomers during toyocamycin and 7-deazainosine syntheses.
Nucleosides, nucleotides & nucleic acids 2009;28(5):678-94.
2009: Frank Seela; Hai Xiong; Peter Leonard; Simone Budow
8-Aza-7-deazaguanine nucleosides and oligonucleotides with octadiynyl side chains: synthesis, functionalization by the azide-alkyne 'click' reaction and nucleobase specific fluorescence quenching of coumarin dye conjugates.
Organic & biomolecular chemistry 2009;7(7):1374-87.
2009: Simone Budow; Peter Leonard; Henning Eickmeier; Hans Reuter; Frank Seela
The N(1)-(2'-deoxyribofuranoside) of 3-iodo-5-nitroindole: a universal nucleoside forming nitro-iodo interactions.
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 3):o100-2.
2008: Venkata Ramana Sirivolu; Padmaja Chittepu; Frank Seela
DNA with branched internal side chains: synthesis of 5-tripropargylamine-dU and conjugation by an azide-alkyne double click reaction.
Chembiochem : a European journal of chemical biology 2008;9(14):2305-16.
2008: Padmaja Chittepu; Venkata Ramana Sirivolu; Frank Seela
Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: synthesis via the azide-alkyne 'click' reaction.
Bioorganic & medicinal chemistry 2008;16(18):8427-39.
2008: Frank Seela; Xin Ming; Henning Eickmeier; Hans Reuter
7-Deaza-2'-deoxyinosine: a nucleoside showing ambiguous base-pairing properties against the four canonical DNA constituents.
Acta crystallographica. Section C, Crystal structure communications 2008;64(Pt 8):o417-9.
2008: Frank Seela; Venkata Ramana Sirivolu
Pyrrolo-dC oligonucleotides bearing alkynyl side chains with terminal triple bonds: synthesis, base pairing and fluorescent dye conjugates prepared by the azide-alkyne "click" reaction.
Organic & biomolecular chemistry 2008;6(9):1674-87.
2008: Frank Seela; Xin Ming; Simone Budow; Henning Eickmeier; Hans Reuter
7-Fluorotubercidin: a halogenated derivative of a naturally occurring nucleoside antimetabolite.
Acta crystallographica. Section C, Crystal structure communications 2008;64(Pt 5):o293-5.
2008: Frank Seela; Xin Ming
2'-Deoxyimmunosine: stereoselective synthesis, base pairing and duplex stability of oligonucleotides containing 8-oxo-7-thiaguanine.
Organic & biomolecular chemistry 2008;6(8):1450-61.
2008: Frank Seela; Simone Budow
Mismatch formation in solution and on DNA microarrays: how modified nucleosides can overcome shortcomings of imperfect hybridization caused by oligonucleotide composition and base pairing.
Molecular bioSystems 2008;4(3):232-45.
2008: Frank Seela; Padmaja Chittepu
6-Azauracil or 8-aza-7-deazaadenine nucleosides and oligonucleotides: the effect of 2'-fluoro substituents and nucleobase nitrogens on conformation and base pairing.
Organic & biomolecular chemistry 2008;6(3):596-607.
2008: Xin Ming; Peter Leonard; Dieter Heindl; Frank Seela
Azide-alkyne "click" reaction performed on oligonucleotides with the universal nucleoside 7-octadiynyl-7-deaza-2'-deoxyinosine.
Nucleic acids symposium series (2004) 2008;(52):471-2.
2008: Frank Seela; Venkata Ramana Sirivolu; Padmaja Chittepu
Modification of DNA with octadiynyl side chains: synthesis, base pairing, and formation of fluorescent coumarin dye conjugates of four nucleobases by the alkyne--azide "click" reaction.
Bioconjugate chemistry 2008;19(1):211-24.
2007: Natalya Ramzaeva; Elisabeth Michalek; Zygmunt Kazimierczuk; Frank Seela; Helmut Rosemeyer
Hoogsteen vs. Watson-Crick base pairing: incorporation of 2-substituted adenine- and 7-deazaadenine 2'-deoxy-beta-D-ribonucleosides into oligonucleotides.
Chemistry & biodiversity 2007;4(12):2725-44.
2007: Frank Seela; Ping Ding; Xiaohua Peng; Henning Eickmeier; Hans Reuter
The 7-bromo derivative of 2-amino-2'-deoxytubercidin fluorinated at the sugar moiety.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 10):o600-2.
2007: Frank Seela; Kuiying Xu
Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism.
Organic & biomolecular chemistry 2007;5(18):3034-45.
2007: Frank Seela; Xin Ming; Simone Budow; Henning Eickmeier; Hans Reuter
2'-Deoxyimmunosine: a thiazolo[4,5-d]pyrimidine nucleoside adopting the syn conformation.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 9):o549-51.
2007: Frank Seela; Simone Budow; Peter Leonard
Oligonucleotides forming an i-motif: the pH-dependent assembly of individual strands and branched structures containing 2'-deoxy-5-propynylcytidine.
Organic & biomolecular chemistry 2007;5(12):1858-72.
2007: Frank Seela; Padmaja Chittepu
Oligonucleotides containing 6-aza-2'-deoxyuridine: synthesis, nucleobase protection, pH-dependent duplex stability, and metal-DNA formation.
The Journal of organic chemistry 2007;72(12):4358-66.
2007: Frank Seela; Padmaja Chittepu; Yang He; Henning Eickmeier; Hans Reuter
6-Aza-2'-deoxyuridine and N(3)-anisoyl-6-aza-2'-deoxyuridine.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 3):o173-6.
2007: Bernd Beermann; Ernesto Carrillo-Nava; Andy Scheffer; Wolfgang Buscher; Anup M Jawalekar; Frank Seela; Hans-Jürgen Hinz
Association temperature governs structure and apparent thermodynamics of DNA-gold nanoparticles.
Biophysical chemistry 2007;126(1-3):124-31.
2007: Frank Seela; Xiaohua Peng; Henning Eickmeier; Hans Reuter
2'-Deoxy-2-fluorotubercidin.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 2):o96-8.
2007: Frank Seela; Simone Budow
pH-dependent assembly of DNA-gold nanoparticles based on the i-motif.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):755-9.
2007: Khalil I Shaikh; Peter Leonard; Frank Seela
7-deaza-2'-deoxyxanthosine: nucleobase protection and base pairing of oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):737-41.
2007: Frank Seela; Kuiying Xu; Padmaja Chittepu; Xin Ming
Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):607-10.
2007: Xiaohua Peng; Frank Seela
An efficient synthesis of 7-functionalized 7-deazapurine beta-D- Or beta-L-ribonucleosides: glycosylation of pyrrolo[2,3-D]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-Or L-ribofuranose.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):603-6.
2007: Frank Seela; Venkata Ramana Sirivolu
Nucleosides and oligonucleotides with diynyl side chains: the huisgen-sharpless cycloaddition "click reaction" performed on DNA and their constituents.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):597-601.
2007: Frank Seela; Xiaohua Peng; Kuiying Xu
Mismatch discrimination of base-modified nucleic acids and their constituents: non-Watson-Crick base pairing induced by tautomerization.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1569-72.
2007: Helmut Rosemeyer; Martina Anders; Frank Seela
Symmetrically and unsymmetrically bridged methylenebis(allopurinols): synthesis of dimeric potential anti-gout drugs.
Molecules (Basel, Switzerland) 2007;12(3):563-75.
2007: Frank Seela; Simone Budow; Henning Eickmeier; Hans Reuter
2'-Deoxy-5-propynylcytidine: a nucleoside forming two solid-state conformations.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 1):o54-7.
2006: Frank Seela; Khalil I Shaikh
pH-Independent triplex formation: hairpin DNA containing isoguanine or 9-deaza-9-propynylguanine in place of protonated cytosine.
Organic & biomolecular chemistry 2006;4(21):3993-4004.
2006: Frank Seela; Xiaohua Peng; Henning Eickmeier; Hans Reuter
2-Amino-7-chloro-2'-deoxytubercidin.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 10):o593-5.
2006: Wen Qing Lin; Xin Ming; Henning Eickmeier; Frank Seela
7-Deaza-2,8-diazaadenosine.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 7):o379-81.
2006: Hong Li; Xiaohua Peng; Peter Leonard; Frank Seela
Binding of actinomycin C1 (D) and actinomin to base-modified oligonucleotide duplexes with parallel chain orientation.
Bioorganic & medicinal chemistry 2006;14(12):4089-100.
2006: Frank Seela; Venkata Ramana Sirivolu
DNA containing side chains with terminal triple bonds: Base-pair stability and functionalization of alkynylated pyrimidines and 7-deazapurines.
Chemistry & biodiversity 2006;3(5):509-14.
2006: Frank Seela; Khalil I Shaikh; Simone Budow; Henning Eickmeier
2'-Deoxy-7-propynyl-7-deazaadenosine: a DNA duplex-stabilizing nucleoside.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 5):o246-8.
2006: Frank Seela; Padmaja Chittepu; Henning Eickmeier
4-Amino-7-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine: a bis-fluorinated analogue of 2'-deoxytubercidin.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 4):o231-3.
2006: Xiaomei Zhang; Simone Budow; Peter Leonard; Henning Eickmeier; Frank Seela
N8-(2'-O-methylribofuranosyl)-8-aza-7-deazaadenine monohydrate.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 2):o79-81.
2006: Frank Seela; Xiaohua Peng
7-Functionalized 7-deazapurine ribonucleosides related to 2-aminoadenosine, guanosine, and xanthosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose.
The Journal of organic chemistry 2006;71(1):81-90.
2006: Xiaohua Peng; Hong Li; Frank Seela
pH-Dependent mismatch discrimination of oligonucleotide duplexes containing 2'-deoxytubercidin and 2- or 7-substituted derivatives: protonated base pairs formed between 7-deazapurines and cytosine.
Nucleic acids research 2006;34(20):5987-6000.
2006: Frank Seela; Xiaohua Peng
Progress in 7-deazapurine - pyrrolo[2,3-d]pyrimidine - ribonucleoside synthesis.
Current topics in medicinal chemistry 2006;6(9):867-92.
2005: Frank Seela; Simone Budow; Khalil I Shaikh; Anup M Jawalekar
Stabilization of tandem dG-dA base pairs in DNA-hairpins: replacement of the canonical bases by 7-deaza-7-propynylpurines.
Organic & biomolecular chemistry 2005;3(23):4221-6.
2005: Frank Seela; Anup M Jawalekar; Simone Budow; Henning Eickmeier
8-Aza-7-deaza-2'-deoxy-2-(methylsulfanyl)adenosine.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 9):o562-4.
2005: Frank Seela; Xiaohua Peng
Synthesis and properties of 7-substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2005;Chapter 1():Unit 1.10.
2005: Frank Seela; Kuiying Xu; Henning Eickmeier
2'-Deoxy-5-fluorotubercidin.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 6):o408-10.
2005: Frank Seela; Xiaohua Peng; Hong Li
Base-pairing, tautomerism, and mismatch discrimination of 7-halogenated 7-deaza-2'-deoxyisoguanosine: oligonucleotide duplexes with parallel and antiparallel chain orientation.
Journal of the American Chemical Society 2005;127(21):7739-51.
2005: Wenqing Lin; Hong Li; Xin Ming; Frank Seela
1,N6-Etheno-7-deaza-2,8-diazaadenosine: syntheses, properties and conversion to 7-deaza-2,8-diazaadenosine.
Organic & biomolecular chemistry 2005;3(9):1714-8.
2005: Frank Seela; Xiaohua Peng
Base-modified oligodeoxyribonucleotides: using pyrrolo[2,3-d]pyrimidines to replace purines.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2005;Chapter 4():Unit 4.25.
2005: Wenqing Lin; Kuiying Xu; Henning Eickmeier; Frank Seela
8-Aza-7-deaza-7-propynyladenosine methanol solvate.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 4):o195-7.
2005: Frank Seela; Khalil I Shaikh; Henning Eickmeier
7-Deaza-2'-deoxyguanosine.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 3):o151-3.
2005: Frank Seela; Venkata Ramana Sirivolu; Junlin He; Henning Eickmeier
3-Bromo-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine: a nucleoside which strongly enhances DNA duplex stability.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 2):o67-9.
2005: Frank Seela; Anup M Jawalekar; Lifeng Chi; Dingyong Zhong
Ion-specific aggregation of gold-DNA nanoparticles using the dG quartet hairpin 5'-d(G4T4G4).
Chemistry & biodiversity 2005;2(1):84-91.
2005: Frank Seela; Anup M Jawalekar; Lijuan Sun; Peter Leonard
Oligonucleotides containing pyrazolo[3,4-d]pyrimidines: 8-Aza-7-deazaadenines with bulky substituents in the 2- or 7-position.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1485-505.
2005: Wenqing Lin; Kuiying Xu; Frank Seela
7-substituted 8-aza-7-deazapurines and 2,8-diaza-7-deaza-purines: synthesis of nucleosides and oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):869-73.
2005: Hong Li; Frank Seela
Parallel and antiparallel DNA: fluorescence quenching of ethidium bromide by 7-deazapurines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):865-8.
2005: Frank Seela; Wenqing Lin; Zygmunt Kazimierczuk; Helmut Rosemeyer; V Glaron; Xiaohua Peng; Yang He; Xin Ming; Mariola Andrzejewska; A Gorska; X Zhang; Henning Eickmeier; P La Colla
L-nucleosides containing modified nucleobases.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):859-63.
2005: Frank Seela; Anup M Jawalekar; Venkata Ramana Sirivolu; Helmut Rosemeyer; Yang He; Peter Leonard
Novel DNA nanoparticles and networks.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):855-8.
2005: Frank Seela; Khalil I Shaikh; Simone Budow; Anup M Jawalekar
Propynyl groups in duplex, hairpin and triplex DNA: 7-deazapurines and 9-deazapurines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):851-4.
2005: Frank Seela; Padmaja Chittepu; Yang He; Junlin He; Kuiying Xu
6-azapyrimidine and 7-deazapurine 2'-deoxy-2'-fluoroarabinonucleosides: synthesis, conformation and properties of oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):847-50.
2005: Frank Seela; Anup M Jawalekar; Lifeng Chi; Dingyong Zhong; Harald Fuchs
Gold DNA-conjugates: ion specific self-assembly of gold nanoparticles via the dG-quartet.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):843-6.
2005: Frank Seela; Xiaohua Peng; Xin Ming
7-deazapurin-2,6-diamine and 7-deazaguanine: synthesis and property of 7-substituted nucleosides and oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):839-41.
2005: Igor Mikhailopulo; Yuri A Sokolov; Junlin He; Padmaja Chittepu; Helmut Rosemeyer; Frank Seela
Comparative conformational analysis of nucleosides by NMR, X-ray, and semi-empirical (PM3 VS. AM1) methods.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):701-5.
2005: Frank Seela; Yunlong Zhang; Kuiying Xu; Henning Eickmeier
7-Vinyl-8-aza-7-deaza-2'-deoxyadenosine monohydrate.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 1):o60-2.
2005: Frank Seela; Yang He; Junlin He; Georg Becher; Rita Kröschel; Matthias Zulauf; Peter Leonard
Base-modified oligonucleotides with increased duplex stability: pyrazolo[3,4-d] pyrimidines replacing purines.
Methods in molecular biology (Clifton, N.J.) 2005;288():165-86.
2004: Hong Li; Xiaohua Peng; Frank Seela
Fluorescence quenching of parallel-stranded DNA bound ethidium bromide: the effect of 7-deaza-2'-deoxyisoguanosine and 7-halogenated derivatives.
Bioorganic & medicinal chemistry letters 2004;14(24):6031-4.
2004: Frank Seela; Padmaja Chittepu; Junlin He; Henning Eickmeier
6-Aza-2'-deoxy-2'-arabinofluorouridine, a 2'-deoxyribonucleoside with an N-sugar conformation in the solid state and in solution.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 12):o884-6.
2004: Xiaohua Peng; Frank Seela
Halogenated 7-deazapurine nucleosides: stereoselective synthesis and conformation of 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides.
Organic & biomolecular chemistry 2004;2(19):2838-46.
2004: Wenqing Lin; Frank Seela; Henning Eickmeier; Hans Reuter
1,N6-Etheno derivative of 7-deaza-2,8-diazaadenosine.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 8):o566-8.
2004: Frank Seela; Meike Lindner; Virginie Glaçon; Wenqing Lin
Pyrazolo[3,4-d][1,2,3]triazine DNA: synthesis and base pairing of 7-deaza-2,8-diaza-2'-deoxyadenosine.
The Journal of organic chemistry 2004;69(14):4695-700.
2004: Frank Seela; Khalil I Shaikh; Henning Eickmeier
7-Deaza-2'-deoxy-7-propynylguanosine.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 7):o489-91.
2004: Elena N Kalinichenko; Tatiana L Podkopaeva; Elena V Budko; Frank Seela; Beihua Dong; Robert Silverman; Jouko Vepsäläinen; Paul F Torrence; Igor Mikhailopulo
3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L.
Bioorganic & medicinal chemistry 2004;12(13):3637-47.
2004: Frank Seela; Anup M Jawalekar; Henning Eickmeier
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-4-nitro-1H-indazole.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 6):o387-9.
2004: Frank Seela; Xiaohua Peng
Regioselective synthesis of indazole N1- and N2-(beta-D-ribonucleosides).
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):227-37.
2004: Frank Seela; Xiaohua Peng; Henning Eickmeier; Hans Reuter
Regioisomeric 4-nitroindazole N1- and N2-(beta-D-ribonucleosides).
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o94-7.
2003: Frank Seela; Rita Kröschel
The base pairing properties of 8-aza-7-deaza-2'-deoxyisoguanosine and 7-halogenated derivatives in oligonucleotide duplexes with parallel and antiparallel chain orientation.
Nucleic acids research 2003;31(24):7150-8.
2003: Frank Seela; Rita Kröschel
Oligonucleotide duplexes containing N8-glycosylated 8-aza-7-deazaguanine and self-assembly of 8-aza-7-deazapurines on the nucleoside and the oligomeric level.
Organic & biomolecular chemistry 2003;1(22):3900-8.
2003: Junlin He; Igor Mikhailopulo; Frank Seela
3-Bromopyrazolo[3,4-d]pyrimidine 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides: modified DNA constituents with an unusually rigid sugar N-conformation.
The Journal of organic chemistry 2003;68(14):5519-24.
2003: Junlin He; Henning Eickmeier; Frank Seela
6-amino-3-bromo-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one-acetone-water (1/1/1): a fluorinated 2'-deoxyguanosine analogue with the sugar conformation of a ribonucleoside.
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 7):o406-8.
2003: Junlin He; Frank Seela
Oligonucleotides incorporating 8-aza-7-deazapurines: synthesis and base pairing of nucleosides with nitrogen-8 as a glycosylation position.
Organic & biomolecular chemistry 2003;1(11):1873-83.
2003: Frank Seela; Khalil I Shaikh; T Wiglenda
Synthesis and properties of halogenated 7-deaza-2'-deoxyxanthosine and protected derivatives for oligonucleotide synthesis.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1239-41.
2003: Peter Leonard; Rita Kröschel; Frank Seela
Oligonucleotides incorporating N7-(2'-deoxy-beta-D-erythro-pentofuranosyl)isoguanine.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1235-7.
2003: Helmut Rosemeyer; Natalya Ramzaeva; E M Becker; Elisabeth Feiling; Frank Seela
Oligonucleotides incorporating 7-(aminoalkyn-1-yl)-7-deaza-2'-deoxyguanosines: duplex stability and phosphodiester hydrolysis by exonucleases.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1231-4.
2003: Junlin He; Georg Becher; Simone Budow; Frank Seela
Pyrazolo[3,4-d]pyrimidine nucleic acids: adjustment of the dA-dT to the dG-dC base pair stability.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):573-6.
2003: Frank Seela; Yang He; Henning Eickmeier
5-Methyl-6-aza-2'-deoxyisocytidine.
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 4):O194-6.
2003: Frank Seela; Yang He
6-aza-2'-deoxyisocytidine: synthesis, properties of oligonucleotides, and base-pair stability adjustment of DNA with parallel strand orientation.
The Journal of organic chemistry 2003;68(2):367-77.
2002: Junlin He; Frank Seela
Propynyl groups in duplex DNA: stability of base pairs incorporating 7-substituted 8-aza-7-deazapurines or 5-substituted pyrimidines.
Nucleic acids research 2002;30(24):5485-96.
2002: Helmut Rosemeyer; Natalya Ramzaeva; Eva-Maria Becker; Elisabeth Feiling; Frank Seela
Oligonucleotides incorporating 7-(aminoalkynyl)-7-deaza-2'-deoxyguanosines: duplex stability and phosphodiester hydrolysis by exonucleases.
Bioconjugate chemistry 2002;13(6):1274-85.
2002: Junlin He; Frank Seela; Henning Eickmeier; Hans Reuter
The regioisomeric 1H(2H)-pyrazolo[3,4-d]pyrimidine N1- and N2-(2'-deoxy-beta-D-ribofuranosides).
Acta crystallographica. Section C, Crystal structure communications 2002;58(Pt 10):o593-5.
2002: Frank Seela; Helmut Rosemeyer; Alexander Melenewski; Eva-Maria Heithoff; Henning Eickmeier; Hans Reuter
The alpha-D anomer of 5-aza-7-deaza-2'-deoxyguanosine.
Acta crystallographica. Section C, Crystal structure communications 2002;58(Pt 3):o142-4.
2001: Matheus Froeyen; Eveline Lescrinier; Luk Kerremans; Helmut Rosemeyer; Frank Seela; Birgit Verbeure; Irene M Lagoja; Jef Rozenski; Arthur Van Aerschot; Roger Busson; Piet Herdewijn
Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(23):5183-94.
2001: Frank Seela; Rita Kröschel
Quadruplex and pentaplex self-assemblies of oligonucleotides containing short runs of 8-aza-7-deaza-2'-deoxyisoguanosine or 2'-deoxyisoguanosine.
Bioconjugate chemistry 2001;12(6):1043-50.
2001: Frank Seela; H Debelak
The C(8)-(2'-deoxy-beta-D-ribofuranoside) of 7-deazaguanine: synthesis and base pairing of oligonucleotides with unusually linked nucleobases.
The Journal of organic chemistry 2001;66(10):3303-12.
2001: Frank Seela; Georg Becher
Pyrazolo[3,4-d]pyrimidine nucleic acids: adjustment of dA-dT to dG-dC base pair stability.
Nucleic acids research 2001;29(10):2069-78.
2001: Frank Seela; Yang He; Hans Reuter; Eva-Maria Heithoff
The high-anti conformation of 8-aza-1,3-dideaza-2'-deoxyadenosine.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 5):660-2.
2001: Frank Seela; Elisabeth Feiling; J Gross; F Hillenkamp; Natalya Ramzaeva; Helmut Rosemeyer; Matthias Zulauf
Fluorescent DNA: the development of 7-deazapurine nucleoside triphosphates applicable for sequencing at the single molecule level.
Journal of biotechnology 2001;86(3):269-79.
2001: Jing Wang; Birgit Verbeure; I Luyten; Matheus Froeyen; C Hendrix; Helmut Rosemeyer; Frank Seela; Arthur Van Aerschot; Piet Herdewijn
Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):785-8.
2001: Frank Seela; H Debelak
8-aza-7-deazaadenine and 7-deazaguanine: synthesis and properties of nucleosides and oligonucleotides with nucleobases linked at position-8.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):577-85.
2001: Frank Seela; Natalya Ramzaeva; Peter Leonard; Y Chen; H Debelak; Elisabeth Feiling; Rita Kröschel; Matthias Zulauf; Thomas Wenzel; T Fröhlich; Markus Kostrzewa
Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1421-4.
2001: Frank Seela; Rita Kröschel; Yang He
Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1283-6.
2001: Peter Leonard; T Wiglenda; Frank Seela
Synthesis and base pairing properties of 9-deazapurine N7-nucleosides in oligonucleotide duplexes and triplexes.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1279-82.
2000: Igor Mikhailopulo; T I Kulak; O V Tkachenko; S L Sentyureva; L S Victorova; Helmut Rosemeyer; Frank Seela
Pyrophosphoryl derivatives of 1-(2-deoxy-3-O-phosphono-methyl-beta- and -alpha-D-erythro-pentofuranosyl)thymine: synthesis and substrate properties towards some DNA polymerases.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1885-909.
2000: Frank Seela; Georg Becher; Y Chen
Fluorescence properties and base pair stability of oligonucleotides containing 8-aza-7-deaza-2'-deoxyisoinosine or 2'-deoxyisoinosine.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1581-98.
2000: Frank Seela; H Debelak
The N(8)-(2'-deoxyribofuranoside) of 8-aza-7-deazaadenine: a universal nucleoside forming specific hydrogen bonds with the four canonical DNA constituents.
Nucleic acids research 2000;28(17):3224-32.
2000: Frank Seela; Yang He; Hans Reuter; Eva-Maria Heithoff
2'-Deoxy-5-methylisocytidine.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 8)():989-91.
2000: Frank Seela; Matthias Zulauf; Hans Reuter; G Kastner
7-Iodo-8-aza-7-deaza-2'-deoxyadenosine and 7-bromo-8-aza-7-deaza-2'-deoxyadenosine.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 4)():489-91.
2000: Frank Seela; C Wei; Georg Becher; Matthias Zulauf; Peter Leonard
The influence of modified purine bases on the stability of parallel DNA.
Bioorganic & medicinal chemistry letters 2000;10(3):289-92.
2000: T Sugiyama; E Schweinberger; Zygmunt Kazimierczuk; Natalya Ramzaeva; Helmut Rosemeyer; Frank Seela
2-aza-2'-deoxyadenosine: synthesis, base-pairing selectivity, and stacking properties of oligonucleotides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(2):369-78.
2000: Frank Seela; Matthias Zulauf; S F Chen
Pyrrolo[2,3-d]pyrimidine nucleosides: synthesis and antitumor activity of 7-substituted 7-deaza-2'-deoxyadenosines.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):237-51.
1998: MR Player; Elena N Kalinichenko; Tatiana L Podkopaeva; Igor Mikhailopulo; Frank Seela; Paul F Torrence
Dissection of the roles of adenine ring nitrogen (N-1) and exocyclic amino (N-6) moieties in the interaction of 2-5A with RNase L.
Biochemical and biophysical research communications 1998;245(2):430-4.
1998: Frank Seela; H Debelak; N Usman; Alex Burgin; Leonid Beigelman
1-Deazaadenosine: synthesis and activity of base-modified hammerhead ribozymes.
Nucleic acids research 1998;26(4):1010-8.
1997: Frank Seela; C Wei; Alexander Melenewski
Four-stranded DNA formed by isoguanine quartets: complex stoichiometry, thermal stability and resistance against exonucleases.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 1997;27(5-6):597-608.
1997: Frank Seela; C Wei; Alexander Melenewski; P Leonard
Parallel-stranded duplexes and quartet assemblies formed by oligonucleotides containing isoguanine.
Nucleic acids symposium series 1997;(37):149-50.
1996: Frank Seela; C Wei; A Melenewski
Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability.
Nucleic acids research 1996;24(24):4940-5.
1996: A Schöppe; Hans-Jürgen Hinz; H Rosemeyer; Frank Seela
Xylose-DNA: comparison of the thermodynamic stability of oligo(2'-deoxyxylonucleotide) and oligo(2'-deoxyribonucleotide) duplexes.
European journal of biochemistry / FEBS 1996;239(1):33-41.
1996: Frank Seela; Y Chen; A Melenewski; H Rosemeyer; C Wei
Synthesis and application of novel nucleoside phosphonates and phosphoramidites modified at the base moiety.
Acta biochimica Polonica 1996;43(1):45-52.
1995: Frank Seela; Y Chen
Oligonucleotides containing fluorescent 2'-deoxyisoinosine: solid-phase synthesis and duplex stability.
Nucleic acids research 1995;23(13):2499-505.
1994: N Ramzaeva; Frank Seela
Photochemical conversion of oligonucleotides containing 2-chloro-2'-deoxyadenosine: enhanced UV sensitivity of a modified purine base induced by the nearest neighbor.
Chemical research in toxicology 1994;7(5):643-9.
1992: Frank Seela; T Grein
7-Deaza-2'-deoxyadenosine and 3-deaza-2'-deoxyadenosine replacing dA within d(A6)-tracts: differential bending at 3'- and 5'-junctions of d(A6).d(T6) and B-DNA.
Nucleic acids research 1992;20(13):2297-306.
1992: Frank Seela; A Röling
7-Deazapurine containing DNA: efficiency of c7GdTP, c7AdTP and c7IdTP incorporation during PCR-amplification and protection from endodeoxyribonuclease hydrolysis.
Nucleic acids research 1992;20(1):55-61.
1991: Frank Seela; H Rosemeyer; M Krecmerova; A Röling
Solid-phase synthesis of oligo(2'-deoxyxylonucleotides) and PCR amplification of base-modified DNA fragments.
Nucleic acids symposium series 1991;(24):87-90.
1989: Frank Seela; H Berg; H Rosemeyer
Bending of oligonucleotides containing an isosteric nucleobase: 7-deaza-2'-deoxyadenosine replacing dA within d(A)6 tracts.
Biochemistry 1989;28(15):6193-8.
1989: Frank Seela; H Driller
Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG.
Nucleic acids research 1989;17(3):901-10.
1987: B Golankiewicz; W Folkman; H Rosemeyer; Frank Seela
15N NMR spectra of wyosine and related ribonucleosides.
Nucleic acids research 1987;15(21):9075.
1987: Frank Seela; W Bourgeois
2'-Deoxy-3,7-dideazaadenosine--synthesis and NMR assignment.
Nucleic acids research 1987;15(17):7208.
1987: Frank Seela; H Rosemeyer; W Bourgeois
Synthesis of 5-aza-7-deazapurine and 3,7-dideazapurine 2'-deoxyribofuranosides by solid-liquid phase-transfer glycosylation.
Nucleic acids symposium series 1987;(18):49-52.
1986: Frank Seela; H Driller
Palindromic oligonucleotides containing 7-deaza-2'-deoxyguanosine: solid-phase synthesis of d[(p)GG*AATTCC] octamers and recognition by the endodeoxyribonuclease EcoRI.
Nucleic acids research 1986;14(5):2319-32.
1985: Frank Seela; H Driller
Solid-phase synthesis of the self-complementary hexamer d(c7GpCpc7GpCpc7GpC) via the O-3'-phosphoramidite of 7-deaza-2'-deoxyguanosine.
Nucleic acids research 1985;13(3):911-26.
1984: Frank Seela; W Bussmann; A Götze; H Rosemeyer
Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase.
Journal of medicinal chemistry 1984;27(8):981-5.
1983: H Rosemeyer; Frank Seela
Methylated 7-deazahypoxanthines as regiochemical probes of xanthine oxidase.
European journal of biochemistry / FEBS 1983;134(3):513-5.
1982: H Rosemeyer; E Körnig; Frank Seela
Dextran-linked purine nucleosides as substrates and inhibitors of adenosine deaminase.
European journal of biochemistry / FEBS 1982;127(1):185-91.
1982: H Rosemeyer; E Körnig; Frank Seela
Adenosine deaminase covalently linked to soluble dextran. The effect of immobilization on thermodynamic and kinetic parameters.
European journal of biochemistry / FEBS 1982;122(2):375-80.
1981: H Rosemeyer; Frank Seela
Quantitative affinity chromatography of adenosine deaminase on polymer-bound inosine: the assessment of binding constants by biospecific elution.
Analytical biochemistry 1981;115(2):339-46.
1981: H Rosemeyer; Frank Seela
Agarose-linked xanthosine: a biospecific resin for guanine aminohydrolase.
Carbohydrate research 1981;90(1):53-60.