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David Segal

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Istvan Botos; David M Segal; David R Davies
The structural biology of Toll-like receptors.
Ivett Jelinek; Joshua N Leonard; Graeme E Price; Kevin N Brown; Anna Meyer-Manlapat; Paul K Goldsmith; Yan Wang; David Venzon; Suzanne L Epstein; David M Segal
TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
Istvan Botos; Lin Liu; Yan Wang; David M Segal; David R Davies
The toll-like receptor 3:dsRNA signaling complex.

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All Publications

2011: Istvan Botos; David M Segal; David R Davies
The structural biology of Toll-like receptors.
Structure (London, England : 1993) 2011;19(4):447-59.
2011: Ivett Jelinek; Joshua N Leonard; Graeme E Price; Kevin N Brown; Anna Meyer-Manlapat; Paul K Goldsmith; Yan Wang; David Venzon; Suzanne L Epstein; David M Segal
TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2422-9.
2009: Istvan Botos; Lin Liu; Yan Wang; David M Segal; David R Davies
The toll-like receptor 3:dsRNA signaling complex.
Biochimica et biophysica acta 2009;1789(9-10):667-74.
2009: Joshua N Leonard; Jessica K Bell; David M Segal
Predicting Toll-like receptor structures and characterizing ligand binding.
Methods in molecular biology (Clifton, N.J.) 2009;517():55-67.
2008: Lin Liu; Istvan Botos; Yan Wang; Joshua N Leonard; Joseph Shiloach; David M Segal; David Davies
Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science (New York, N.Y.) 2008;320(5874):379-81.
2008: Joshua N Leonard; Rodolfo Ghirlando; Janine Askins; Jessica K Bell; David Margulies; David Davies; David M Segal
The TLR3 signaling complex forms by cooperative receptor dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):258-63.
2007: Can Kocabas; Nora Katsenelson; Sunita Kanswal; Margaret N Kennedy; Xinle Cui; Milan S Blake; David M Segal; Mustafa Akkoyunlu
Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14.
Cellular microbiology 2007;9(5):1297-310.
2006: Cynthia A Leifer; James C Brooks; Karin Hoelzer; Jody Lopez; Margaret N Kennedy; Alessandra Mazzoni; David M Segal
Cytoplasmic targeting motifs control localization of toll-like receptor 9.
The Journal of biological chemistry 2006;281(46):35585-92.
2006: Alessandra Mazzoni; Reuben P Siraganian; Cynthia A Leifer; David M Segal
Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3577-81.
2006: Zhao Yuan Wang; De Yang; Qian Chen; Cynthia A Leifer; David M Segal; Shao Bo Su; Rachel R Caspi; Zack O M Howard; Joost J Oppenheim
Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Experimental hematology 2006;34(8):1115-24.
2006: Jessica K Bell; Janine Askins; Pamela R Hall; David Davies; David M Segal
The dsRNA binding site of human Toll-like receptor 3.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8792-7.
2006: Jessica K Bell; Istvan Botos; Pamela R Hall; Janine Askins; Joseph Shiloach; David Davies; David M Segal
The molecular structure of the TLR3 extracellular domain.
Journal of endotoxin research 2006;12(6):375-8.
2005: Jaya Talreja; Kavitha Dileepan; Sanjeev Puri; Mohammad H Kabir; David M Segal; Daniel J Stechschulte; Kottarappat N Dileepan
Human conjunctival epithelial cells lack lipopolysaccharide responsiveness due to deficient expression of MD2 but respond after interferon-gamma priming or soluble MD2 supplementation.
Inflammation 2005;29(4-6):170-81.
2005: Jessica K Bell; Istvan Botos; Pamela R Hall; Janine Askins; Joseph Shiloach; David M Segal; David Davies
The molecular structure of the Toll-like receptor 3 ligand-binding domain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10976-80.
2004: Margaret N Kennedy; Gregory E D Mullen; Cynthia A Leifer; ChangWoo Lee; Alessandra Mazzoni; Kottarappat N Dileepan; David M Segal
A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.
The Journal of biological chemistry 2004;279(33):34698-704.
2004: Cynthia A Leifer; Margaret N Kennedy; Alessandra Mazzoni; ChangWoo Lee; Michael J Kruhlak; David M Segal
TLR9 is localized in the endoplasmic reticulum prior to stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1179-83.
2004: Alessandra Mazzoni; David M Segal
Controlling the Toll road to dendritic cell polarization.
Journal of leukocyte biology 2004;75(5):721-30.
2003: Jessica K Bell; Gregory E D Mullen; Cynthia A Leifer; Alessandra Mazzoni; David Davies; David M Segal
Leucine-rich repeats and pathogen recognition in Toll-like receptors.
Trends in immunology 2003;24(10):528-33.
2003: Li-Yun Huang; Julio Aliberti; Cynthia A Leifer; David M Segal; Alan Sher; Douglas T Golenbock; Basil Golding
Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1441-6.
2003: Vincenzo Bronte; paolo serafini; Alessandra Mazzoni; David M Segal; Paola Zanovello
L-arginine metabolism in myeloid cells controls T-lymphocyte functions.
Trends in immunology 2003;24(6):302-6.
2003: Gregory E D Mullen; Margaret N Kennedy; Alberto Visintin; Alessandra Mazzoni; Cynthia A Leifer; David Davies; David M Segal
The role of disulfide bonds in the assembly and function of MD-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3919-24.
2003: Alessandra Mazzoni; Cynthia A Leifer; Gregory E D Mullen; Margaret N Kennedy; Dennis M Klinman; David M Segal
Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2269-73.
2003: Vincenzo Bronte; paolo serafini; Carmela De Santo; Ilaria Marigo; Valeria Tosello; Alessandra Mazzoni; David M Segal; Caroline Staib; Marianne Lowel; Gerd Sutter; Mario P Colombo; Paola Zanovello
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):270-8.
2002: Arya Biragyn; Pier Adelchi Ruffini; Cynthia A Leifer; Elena N Klyushnenkova; Alexander N Shakhov; Oleg Chertov; Aiko K Shirakawa; Joshua M Farber; David M Segal; Joost J Oppenheim; Larry W Kwak
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.
Science (New York, N.Y.) 2002;298(5595):1025-9.
2002: Jessica H Spitzer; Alberto Visintin; Alessandra Mazzoni; Margaret N Kennedy; David M Segal
Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells.
European journal of immunology 2002;32(4):1182-7.
2002: Alessandra Mazzoni; Vincenzo Bronte; Alberto Visintin; Jessica H Spitzer; Elisa Apolloni; paolo serafini; Paola Zanovello; David M Segal
Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):689-95.
2001: Alessandra Mazzoni; H A Young; Jessica H Spitzer; Alberto Visintin; David M Segal
Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.
The Journal of clinical investigation 2001;108(12):1865-73.
2001: Alberto Visintin; Alessandra Mazzoni; J A Spitzer; David M Segal
Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12156-61.
2001: David M Segal
Measurement of intercellular conjugates by flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 5():Unit 5.6.
2001: David M Segal; bert bast
Production of bispecific antibodies.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 2():Unit 2.13.
2001: David M Segal; G J Weiner; L M Weiner
Introduction: bispecific antibodies.
Journal of immunological methods 2001;248(1-2):1-6.
2001: Alberto Visintin; Alessandra Mazzoni; Jessica H Spitzer; David H Wyllie; Steven K Dower; David M Segal
Regulation of Toll-like receptors in human monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):249-55.
2000: David H Wyllie; Endre Kiss-Toth; Alberto Visintin; S C Smith; S Boussouf; David M Segal; Gordon W Duff; Steven K Dower
Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7125-32.
2000: Elisa Apolloni; Vincenzo Bronte; Alessandra Mazzoni; paolo serafini; Anna Cabrelle; David M Segal; H A Young; Paola Zanovello
Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6723-30.
1999: G Sconocchia; J A Titus; Alessandra Mazzoni; Alberto Visintin; Federica Pericle; S W Hicks; F Malavasi; David M Segal
CD38 triggers cytotoxic responses in activated human natural killer cells.
Blood 1999;94(11):3864-71.
1999: David M Segal; G J Weiner; L M Weiner
Bispecific antibodies in cancer therapy.
Current opinion in immunology 1999;11(5):558-62.
1999: Olivier A Harari; T J Wickham; CJ Stocker; Imre Kovesdi; David M Segal; T Y Huehns; C Sarraf; Dorian O Haskard
Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin.
Gene therapy 1999;6(5):801-7.
1998: Federica Pericle; Ligia A Pinto; S Hicks; Robert A Kirken; G Sconocchia; J Rusnak; Matthew J Dolan; Gene M Shearer; David M Segal
HIV-1 infection induces a selective reduction in STAT5 protein expression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):28-31.
1997: T J Wickham; G M Lee; J A Titus; G Sconocchia; T Bakács; Imre Kovesdi; David M Segal
Targeted adenovirus-mediated gene delivery to T cells via CD3.
Journal of virology 1997;71(10):7663-9.
1997: Federica Pericle; Robert A Kirken; Vincenzo Bronte; G Sconocchia; L DaSilva; David M Segal
Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2580-5.
1997: Barbara A Vance; W Wu; RK Ribaudo; David M Segal; Kelly P Kearse
Multiple dimeric forms of human CD69 result from differential addition of N-glycans to typical (Asn-X-Ser/Thr) and atypical (Asn-X-cys) glycosylation motifs.
The Journal of biological chemistry 1997;272(37):23117-22.
1997: G Sconocchia; J A Titus; David M Segal
Signaling pathways regulating CD44-dependent cytolysis in natural killer cells.
Blood 1997;90(2):716-25.
1996: Barbara A Vance; C M Zacharchuk; David M Segal
Recombinant mouse Bcl-2(1-203). Two domains connected by a long protease-sensitive linker.
The Journal of biological chemistry 1996;271(48):30811-5.
1996: Federica Pericle; G Sconocchia; J A Titus; David M Segal
CD44 is a cytotoxic triggering molecule on human polymorphonuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4657-63.
1996: T J Wickham; David M Segal; Peter W Roelvink; M E Carrion; Alena Lizonova; G M Lee; Imre Kovesdi
Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies.
Journal of virology 1996;70(10):6831-8.
1996: C R Jost; J A Titus; I Kurucz; David M Segal
A single-chain bispecific Fv2 molecule produced in mammalian cells redirects lysis by activated CTL.
Molecular immunology 1996;33(2):211-9.
1995: I Kurucz; J A Titus; C R Jost; David M Segal
Correct disulfide pairing and efficient refolding of detergent-solubilized single-chain Fv proteins from bacterial inclusion bodies.
Molecular immunology 1995;32(17-18):1443-52.
1995: David M Segal; G Sconocchia; J A Titus; C R Jost; I Kurucz
Alternative triggering molecules and single chain bispecific antibodies.
Journal of hematotherapy 1995;4(5):377-82.
1995: Andrew J T George; J A Titus; C R Jost; I Kurucz; P Perez; S M Andrew; P J Nicholls; J S Huston; David M Segal
Redirection of cellular cytotoxicity. A two-step approach using recombinant single-chain Fv molecules.
Cell biophysics 1995;26(3):153-65.
1995: T Bakács; J Lee; M B Moreno; C M Zacharchuk; MS Cole; JY Tso; Chang H Paik; J M Ward; David M Segal
A bispecific antibody prolongs survival in mice bearing lung metastases of syngeneic mammary adenocarcinoma.
International immunology 1995;7(6):947-55.
1995: I Kurucz; J A Titus; C R Jost; C M Jacobus; David M Segal
Retargeting of CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4576-82.
1995: M B Moreno; J A Titus; MS Cole; JY Tso; Nhat Le; Chang H Paik; T Bakács; C M Zacharchuk; David M Segal; John R Wunderlich
Bispecific antibodies retarget murine T cell cytotoxicity against syngeneic breast cancer in vitro and in vivo.
Cancer immunology, immunotherapy : CII 1995;40(3):182-90.
1995: Yoram Reiter; I Kurucz; Ulrich Brinkmann; S H Jung; Byungkook Lee; David M Segal; Ira Pastan
Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure.
Immunity 1995;2(3):281-7.
1994: G Sconocchia; J A Titus; David M Segal
CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5473-81.
1994: C R Jost; I Kurucz; C M Jacobus; J A Titus; Andrew J T George; David M Segal
Mammalian expression and secretion of functional single-chain Fv molecules.
The Journal of biological chemistry 1994;269(42):26267-73.
1994: Andrew J T George; J A Titus; C R Jost; I Kurucz; P Perez; S M Andrew; P J Nicholls; J S Huston; David M Segal
Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1802-11.
1993: I Kurucz; C R Jost; Andrew J T George; S M Andrew; David M Segal
A bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3830-4.
1992: David M Segal; J H Qian; Delia Mezzanzanica; M A Garrido; J A Titus; S M Andrew; Andrew J T George; C R Jost; P Perez; John R Wunderlich
Targeting of anti-tumor responses with bispecific antibodies.
Immunobiology 1992;185(2-4):390-402.
1992: John R Wunderlich; Delia Mezzanzanica; M A Garrido; D S Neblock; P E Daddona; S M Andrew; V R Zurawski; S Canevari; M I Colnaghi; David M Segal
Bispecific antibodies and retargeted cellular cytotoxicity: novel approaches to cancer therapy.
International journal of clinical & laboratory research 1992;22(1):17-20.
1992: David M Segal; J H Qian; J A Titus; M B Moreno; Andrew J T George; C R Jost; I Kurucz; M el-Gamil; John R Wunderlich
Targeted cytokine production.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1992;7():36-8.
1991: David M Segal; J H Qian; S M Andrew; J A Titus; Delia Mezzanzanica; M A Garrido; John R Wunderlich
Cytokine release by peripheral blood lymphocytes targeted with bispecific antibodies, and its role in blocking tumor growth.
Annals of the New York Academy of Sciences 1991;636():288-94.
1991: Delia Mezzanzanica; M A Garrido; D S Neblock; P E Daddona; S M Andrew; V R Zurawski; David M Segal; John R Wunderlich
Human T-lymphocytes targeted against an established human ovarian carcinoma with a bispecific F(ab')2 antibody prolong host survival in a murine xenograft model.
Cancer research 1991;51(20):5716-21.
1991: D P Snider; I K Uppenkamp; J A Titus; David M Segal
Processing fate of protein antigen attached to IgD or MHC molecules on normal B lymphocytes using heterocrosslinked bispecific antibodies.
Molecular immunology 1991;28(7):779-88.
1991: J H Qian; J A Titus; S M Andrew; Delia Mezzanzanica; M A Garrido; John R Wunderlich; David M Segal
Human peripheral blood lymphocytes targeted with bispecific antibodies release cytokines that are essential for inhibiting tumor growth.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):3250-6.
1990: David M Segal; M A Garrido; J H Qian; Delia Mezzanzanica; S Andrew; P Perez; I Kurucz; M J Valdayo; J A Titus; D Mezzananica
Effectors of targeted cellular cytotoxicity.
Molecular immunology 1990;27(12):1339-42.
1990: M A Garrido; M J Valdayo; D F Winkler; J A Titus; T T Hecht; P Perez; David M Segal; John R Wunderlich
Targeting human T-lymphocytes with bispecific antibodies to react against human ovarian carcinoma cells growing in nu/nu mice.
Cancer research 1990;50(14):4227-32.
1990: D P Snider; Andreas Kaubisch; David M Segal
Enhanced antigen immunogenicity induced by bispecific antibodies.
The Journal of experimental medicine 1990;171(6):1957-63.
1990: M A Garrido; P Perez; J A Titus; M J Valdayo; D F Winkler; S A Barbieri; John R Wunderlich; David M Segal
Targeted cytotoxic cells in human peripheral blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):2891-8.
1990: M A Garrido; M J Valdayo; D F Winkler; J A Titus; T T Hecht; P Perez; David M Segal; John R Wunderlich
Refocusing the immune system to react with human tumors by targeting human lymphocytes with bispecific antibodies.
Developments in biological standardization 1990;71():33-42.
1989: D P Snider; David M Segal
Efficiency of antigen presentation after antigen targeting to surface IgD, IgM, MHC, Fc gamma RII, and B220 molecules on murine splenic B cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):59-65.
1989: Karen S Hathcock; David M Segal; Richard J Hodes
Activation of Lyt-2+ (CD8+) and L3T4+ (CD4+) T cell subsets by anti-receptor antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2181-6.
1989: R R Quinones; David M Segal; Pierre A Henkart; P Perez; Ronald E Gress
Inhibition of cytotoxic T cell lysis by anti-CD8 monoclonal antibodies: studies with CD3-targeted cytolysis of nominal antigen-negative targets.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2200-6.
1988: David M Segal; M A Garrido; P Perez; J A Titus; D A Winkler; D B Ring; Andreas Kaubisch; John R Wunderlich
Targeted cytotoxic cells as a novel form of cancer immunotherapy.
Molecular immunology 1988;25(11):1099-103.
1988: David M Segal; John R Wunderlich
Targeting of cytotoxic cells with heterocrosslinked antibodies.
Cancer investigation 1988;6(1):83-92.
1988: David M Segal; J H Qian; M A Garrido; P Perez; D F Winkler; John R Wunderlich; D P Snider; M J Valdayo; J A Titus
Targeting of cytotoxic cells against tumors with heterocrosslinked, bispecific antibodies.
Princess Takamatsu symposia 1988;19():323-31.
1987: O Leo; M Foo; Pierre A Henkart; P Perez; N Shinohara; David M Segal; J A Bluestone
Role of accessory molecules in signal transduction of cytolytic T lymphocyte by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3556-63.
1987: J A Titus; P Perez; Andreas Kaubisch; M A Garrido; David M Segal
Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):3153-8.
1987: J A Titus; M A Garrido; T T Hecht; D F Winkler; John R Wunderlich; David M Segal
Human T cells targeted with anti-T3 cross-linked to antitumor antibody prevent tumor growth in nude mice.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):4018-22.