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Deborah Segaloff

Research Profile

Chemicals & Drugs

Anatomy

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Rats

Genes & Molecular Sequences

Amino Acid Sequences

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Molecular Sequence Data

Disorders

Precocious Puberty

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Publications

TOP 3
Meilin Zhang; Rongbin Guan; Deborah L Segaloff
Revisiting and questioning functional rescue between dimerized LH receptor mutants.
Deborah L Segaloff
Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors.
Rongbin Guan; Xueqing Wu; Xiuyan Feng; Meilin Zhang; Terence E Hébert; Deborah L Segaloff
Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.

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All Publications

2012: Meilin Zhang; Rongbin Guan; Deborah L Segaloff
Revisiting and questioning functional rescue between dimerized LH receptor mutants.
Molecular endocrinology (Baltimore, Md.) 2012;26(4):655-68.
2012: Deborah L Segaloff
Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors.
Sub-cellular biochemistry 2012;63():113-29.
2010: Rongbin Guan; Xueqing Wu; Xiuyan Feng; Meilin Zhang; Terence E Hébert; Deborah L Segaloff
Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.
Cellular signalling 2010;22(2):247-56.
2009: Meilin Zhang; Xiuyan Feng; Rongbin Guan; Terence E Hébert; Deborah L Segaloff
A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.
Cellular signalling 2009;21(11):1663-71.
2009: Rongbin Guan; Xiuyan Feng; Xueqing Wu; Meilin Zhang; Xuesen Zhang; Terence E Hébert; Deborah L Segaloff
Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.
The Journal of biological chemistry 2009;284(12):7483-94.
2008: Xiuyan Feng; Thomas Müller; Dario Mizrachi; Francesca Fanelli; Deborah L Segaloff
An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.
Endocrinology 2008;149(4):1705-17.
2007: Meilin Zhang; Ya-Xiong Tao; Ginny L Ryan; Xiuyan Feng; Francesca Fanelli; Deborah L Segaloff
Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.
The Journal of biological chemistry 2007;282(35):25527-39.
2007: Ginny L Ryan; Xiuyan Feng; Catarina Brasil d'Alva; Meilin Zhang; Bradley J Van Voorhis; Emilia Pinto; Ana Elisa F Kubias; Sonir R Antonini; Ana Claudia Latronico; Deborah L Segaloff
Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.
The Journal of clinical endocrinology and metabolism 2007;92(6):2312-7.
2007: Karina Cocco Monteiro Freitas; Ginny Ryan; Vinicius Nahime Brito; Ya-Xiong Tao; Elaine Maria Frade Costa; Berenice B Mendonca; Deborah L Segaloff; Ana Claudia Latronico
Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism.
Fertility and sterility 2007;87(3):627-34.
2007: Ana Claudia Latronico; Deborah L Segaloff
Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor.
Molecular and cellular endocrinology 2007;260-262():287-93.
2005: Ya-Xiong Tao; Deborah L Segaloff
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.
The Journal of clinical endocrinology and metabolism 2005;90(10):5632-8.
2005: Meilin Zhang; Dario Mizrachi; Francesca Fanelli; Deborah L Segaloff
The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor.
The Journal of biological chemistry 2005;280(28):26169-76.
2004: Ya-Xiong Tao; Deborah L Segaloff
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.
The Journal of clinical endocrinology and metabolism 2004;89(8):3936-42.
2004: Dario Mizrachi; Deborah L Segaloff
Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1768-77.
2004: Ya-Xiong Tao; Nathan B Johnson; Deborah L Segaloff
Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.
The Journal of biological chemistry 2004;279(7):5904-14.
2003: Patricia A Donohoue; Ya-Xiong Tao; Malia Collins; Giles S H Yeo; Stephen O'Rahilly; Deborah L Segaloff
Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.
The Journal of clinical endocrinology and metabolism 2003;88(12):5841-5.
2003: Ya-Xiong Tao; Deborah L Segaloff
Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.
Endocrinology 2003;144(10):4544-51.
2003: Hiromitsu Shinozaki; Viktor Butnev; Ya-Xiong Tao; Kok Long Ang; Marco Conti; Deborah L Segaloff
Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.
The Journal of clinical endocrinology and metabolism 2003;88(3):1194-204.
2002: Julie Jaquette; Deborah L Segaloff
Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain.
Molecular and cellular endocrinology 2002;194(1-2):211-5.
2002: Ya-Xiong Tao; Dario Mizrachi; Deborah L Segaloff
Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1881-92.
2002: Mario Ascoli; Francesca Fanelli; Deborah L Segaloff
The lutropin/choriogonadotropin receptor, a 2002 perspective.
Endocrine reviews 2002;23(2):141-74.
2002: David P Davis; Deborah L Segaloff
N-linked carbohydrates on G protein-coupled receptors: mapping sites of attachment and determining functional roles.
Methods in enzymology 2002;343():200-12.
2001: Hiromitsu Shinozaki; Francesca Fanelli; Xiaoming Liu; Julie Jaquette; K Nakamura; Deborah L Segaloff
Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness.
Molecular endocrinology (Baltimore, Md.) 2001;15(6):972-84.
2001: S Chen; Xiaoming Liu; Deborah L Segaloff
Identification of an SAS (Sp1c adjacent site)-like element in the distal 5'-flanking region of the rat lutropin receptor gene essential for cyclic adenosine 3',5'-monophosphate responsiveness.
Endocrinology 2001;142(5):2013-21.
2001: Meilin Zhang; H Shi; Deborah L Segaloff; Bradley J Van Voorhis; M Zheng
Expression and localization of luteinizing hormone receptor in the female mouse reproductive tract.
Biology of reproduction 2001;64(1):179-87.
2000: Ana Claudia Latronico; Hiromitsu Shinozaki; G Guerra; M A Pereira; Sofia H V Lemos-Marini; Maria Tereza M Baptista; Ivo J P Arnhold; Francesca Fanelli; Berenice B Mendonca; Deborah L Segaloff
Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix.
The Journal of clinical endocrinology and metabolism 2000;85(12):4799-805.
2000: S Chen; Xiaoming Liu; Deborah L Segaloff
A novel cyclic adenosine 3',5'-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells.
Molecular endocrinology (Baltimore, Md.) 2000;14(9):1498-508.
2000: Ya-Xiong Tao; Amy N Abell; Xiaoming Liu; K Nakamura; Deborah L Segaloff
Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.
Molecular endocrinology (Baltimore, Md.) 2000;14(8):1272-82.
1999: Ana Claudia Latronico; Deborah L Segaloff
Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.
American journal of human genetics 1999;65(4):949-58.
1999: S Chen; H Shi; Xiaoming Liu; Deborah L Segaloff
Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells.
Endocrinology 1999;140(5):2100-9.
1998: Amy N Abell; D J McCormick; Deborah L Segaloff
Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs.
Molecular endocrinology (Baltimore, Md.) 1998;12(12):1857-69.
1998: Ana Claudia Latronico; Amy N Abell; Ivo J P Arnhold; Xiaoming Liu; Theresa S Soares Lins; Vinicius Nahime Brito; Ana Elisa C Billerbeck; Deborah L Segaloff; Berenice B Mendonca
A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty.
The Journal of clinical endocrinology and metabolism 1998;83(7):2435-40.
1998: T G Rozell; D P Davis; Y Chai; Deborah L Segaloff
Association of gonadotropin receptor precursors with the protein folding chaperone calnexin.
Endocrinology 1998;139(4):1588-93.
1998: Ana Claudia Latronico; Y Chai; Ivo J P Arnhold; X Liu; B B Mendonca; Deborah L Segaloff
A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor.
Molecular endocrinology (Baltimore, Md.) 1998;12(3):442-50.
1997: Amy N Abell; Deborah L Segaloff
Evidence for the direct involvement of transmembrane region 6 of the lutropin/choriogonadotropin receptor in activating Gs.
The Journal of biological chemistry 1997;272(23):14586-91.
1997: D P Davis; T G Rozell; Xiaoming Liu; Deborah L Segaloff
The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction.
Molecular endocrinology (Baltimore, Md.) 1997;11(5):550-62.
1997: Julie Jaquette; Deborah L Segaloff
Temperature sensitivity of some mutants of the lutropin/choriogonadotropin receptor.
Endocrinology 1997;138(1):85-91.
1996: D Thomas; T G Rozell; Xiaoming Liu; Deborah L Segaloff
Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucine-rich repeats 1-6 are involved in hormone binding.
Molecular endocrinology (Baltimore, Md.) 1996;10(6):760-8.
1996: Amy N Abell; Xiaoming Liu; Deborah L Segaloff
Deletions of portions of the extracellular loops of the lutropin/choriogonadotropin receptor decrease the binding affinity for ovine luteinizing hormone, but not human choriogonadotropin, by preventing the formation of mature cell surface receptor.
The Journal of biological chemistry 1996;271(8):4518-27.
1995: T G Rozzell; H Wang; Xiaoming Liu; Deborah L Segaloff
Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not of the lutropin/choriogonadotropin receptor.
Molecular endocrinology (Baltimore, Md.) 1995;9(12):1727-36.
1995: H Shi; Deborah L Segaloff
A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):734-44.
1995: D Davis; Xiaoming Liu; Deborah L Segaloff
Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function.
Molecular endocrinology (Baltimore, Md.) 1995;9(2):159-70.
1994: D M Thomas; Deborah L Segaloff
Hormone-binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor expressed in mammalian cells.
Endocrinology 1994;135(5):1902-12.
1993: H Wang; Julie Jaquette; K Collison; Deborah L Segaloff
Positive charges in a putative amphiphilic helix in the carboxyl-terminal region of the third intracellular loop of the luteinizing hormone/chorionic gonadotropin receptor are not required for hormone-stimulated cAMP production but are necessary for expression of the receptor at the plasma membrane.
Molecular endocrinology (Baltimore, Md.) 1993;7(11):1437-44.
1993: Deborah L Segaloff; Mario Ascoli
The lutropin/choriogonadotropin receptor ... 4 years later.
Endocrine reviews 1993;14(3):324-47.
1993: Xiaoming Liu; D Davis; Deborah L Segaloff
Disruption of potential sites for N-linked glycosylation does not impair hormone binding to the lutropin/choriogonadotropin receptor if Asn-173 is left intact.
The Journal of biological chemistry 1993;268(3):1513-6.
1992: Erwin F Shibata; J J Matsuda; Kenneth A Volk; K A Collison; Deborah L Segaloff
Evidence that the FSH receptor itself is not a calcium channel.
Endocrinology 1992;131(2):979-81.
1992: Jesús Sánchez-Yagüe; Marina C Rodríguez; Deborah L Segaloff; Mario Ascoli
Truncation of the cytoplasmic tail of the lutropin/choriogonadotropin receptor prevents agonist-induced uncoupling.
The Journal of biological chemistry 1992;267(11):7217-20.
1992: M C Rodriguez; Y B Xie; H Wang; K Collison; Deborah L Segaloff
Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.
Molecular endocrinology (Baltimore, Md.) 1992;6(3):327-36.
1992: H Wang; S Nelson; Mario Ascoli; Deborah L Segaloff
The 5'-flanking region of the rat luteinizing hormone/chorionic gonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by 3',5'-cyclic adenosine monophosphate.
Molecular endocrinology (Baltimore, Md.) 1992;6(3):320-6.
1991: H Wang; Mario Ascoli; Deborah L Segaloff
Multiple luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid transcripts.
Endocrinology 1991;129(1):133-8.
1991: H Wang; Deborah L Segaloff; Mario Ascoli
Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor.
Endocrinology 1991;128(5):2651-3.
1991: H Wang; Deborah L Segaloff; Mario Ascoli
Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA.
The Journal of biological chemistry 1991;266(2):780-5.
1990: Y B Xie; H Wang; Deborah L Segaloff
Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity.
The Journal of biological chemistry 1990;265(35):21411-4.
1990: Deborah L Segaloff; H Y Wang; J S Richards
Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1856-65.
1990: A L Frazier; L S Robbins; Philip J S Stork; Rolf Sprengel; Deborah L Segaloff; Roger D Cone
Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1264-76.
1990: M C Rodriguez; Deborah L Segaloff
The orientation of the lutropin/choriogonadotropin receptor in rat luteal cells as revealed by site-specific antibodies.
Endocrinology 1990;127(2):674-81.
1990: Rolf Sprengel; T Braun; K Nikolics; Deborah L Segaloff; P H Seeburg
The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA.
Molecular endocrinology (Baltimore, Md.) 1990;4(4):525-30.
1990: Deborah L Segaloff; Rolf Sprengel; K Nikolics; Mario Ascoli
Structure of the lutropin/choriogonadotropin receptor.
Recent progress in hormone research 1990;46():261-301; discussion 301-3.
1989: K C McFarland; Rolf Sprengel; Heidi S Phillips; M Köhler; N Rosemblit; K Nikolics; Deborah L Segaloff; P H Seeburg
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.
Science (New York, N.Y.) 1989;245(4917):494-9.
1989: Mario Ascoli; O P Pignataro; Deborah L Segaloff
The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin.
The Journal of biological chemistry 1989;264(12):6674-81.
1989: Mario Ascoli; Deborah L Segaloff
On the structure of the luteinizing hormone/chorionic gonadotropin receptor.
Endocrine reviews 1989;10(1):27-44.
1988: N Rosemblit; Mario Ascoli; Deborah L Segaloff
Characterization of an antiserum to the rat luteal luteinizing hormone/chorionic gonadotropin receptor.
Endocrinology 1988;123(5):2284-90.
1988: M E Pereira; Deborah L Segaloff; Mario Ascoli
Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.
The Journal of biological chemistry 1988;263(20):9761-6.
1988: M E Pereira; Deborah L Segaloff; Mario Ascoli
Ca+2 is an inhibitor of adenylate cyclase in MA-10 Leydig tumor cells.
Endocrinology 1988;122(5):2232-9.