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Per Seglen

Research Profile

Physiology

Living Beings

Anatomy

Chemicals & Drugs

Disorders

Liver Neoplasms, Experimental

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Publications

TOP 3
Anders Øverbye; Linda Korseberg Hagen; HT Johansen; Frank Sætre; Per O Seglen
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Eeva-Liisa Eskelinen; Attila L Kovacs; Fulvio Reggiori; Misuzu Baba; Per O Seglen
Seeing is believing: the impact of electron microscopy on autophagy research.
Daniel J Klionsky; Per O Seglen
The Norse god of autophagy. Interviewed by Daniel J Klionsky.

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All Publications

2011: Anders Øverbye; Linda Korseberg Hagen; HT Johansen; Frank Sætre; Per O Seglen
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Autophagy 2011;7(9):1011-27.
2011: Eeva-Liisa Eskelinen; Attila L Kovacs; Fulvio Reggiori; Misuzu Baba; Per O Seglen
Seeing is believing: the impact of electron microscopy on autophagy research.
Autophagy 2011;7(9):935-56.
2010: Daniel J Klionsky; Per O Seglen
The Norse god of autophagy. Interviewed by Daniel J Klionsky.
Autophagy 2010;6(8):1017-31.
2010: Per O Seglen; Monica Fengsrud Brinchmann
Purification of autophagosomes from rat hepatocytes.
Autophagy 2010;6(4):542-7.
2009: Per O Seglen; Anders Øverbye; Frank Saetre
Sequestration assays for mammalian autophagy.
Methods in enzymology 2009;452():63-83.
2008: Daniel J Klionsky; Zvulun Elazar; Per O Seglen; David C Rubinsztein
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
Autophagy 2008;4(7):849-950.
2007: Daniel J Klionsky; Ana Maria Cuervo; William A Dunn; Beth Levine; Ida Van der klei; Per O Seglen
How shall I eat thee?
Autophagy 2007;3(5):413-6.
2007: Anders Øverbye; Monica Fengsrud; Per O Seglen
Proteomic analysis of membrane-associated proteins from rat liver autophagosomes.
Autophagy 2007;3(4):300-22.
2007: Daniel J Klionsky; Ana Maria Cuervo; Per O Seglen
Methods for monitoring autophagy from yeast to human.
Autophagy 2007;3(3):181-206.
2005: Marianne Lunde Sneve; Anders Øverbye; Monica Fengsrud; Per O Seglen
Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels.
Autophagy 2005;1(3):157-62.
2005: Rune I Lindstad; Ingebrigt Sylte; Svein-Ole Mikalsen; Per O Seglen; Eli Berg; Jan-Olof Winberg
Pancreatic trypsin activates human promatrix metalloproteinase-2.
Journal of molecular biology 2005;350(4):682-98.
2005: Hamid R Samari; Michael T N Møller; Lise Holden; Tonje Asmyhr; Per O Seglen
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins.
The Biochemical journal 2005;386(Pt 2):237-44.
2004: Michael T N Møller; Hamid R Samari; Per O Seglen
Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):628-37.
2004: Tor Erik Rusten; Karine Lindmo; Gábor Juhász; Miklós Sass; Per O Seglen; Andreas Brech; Harald Stenmark
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.
Developmental cell 2004;7(2):179-92.
2003: Michael T N Møller; Hamid R Samari; Monica Fengsrud; Per E Strømhaug; Anne C øStvold; Per O Seglen
Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
The Biochemical journal 2003;373(Pt 2):505-13.
2002: Ann-Kristin Ruud Larsen; Michael T N Møller; Henrietta Blankson; Hamid R Samari; Lise Holden; Per O Seglen
Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes.
The Journal of biological chemistry 2002;277(38):34826-35.
2001: Seyed Ali Mousavi; Rune Kjeken; T O Berg; Per O Seglen; Trond Berg; Andreas Brech
Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy.
Biochimica et biophysica acta 2001;1510(1-2):243-57.
2001: G Berven; F Saetre; K Halvorsen; Per O Seglen
Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells.
Toxicon : official journal of the International Society on Toxinology 2001;39(2-3):349-62.
2000: Monica Fengsrud; Camilla Raiborg; TO Berg; Per E Strømhaug; T Ueno; E S Erichsen; Per O Seglen
Autophagosome-associated variant isoforms of cytosolic enzymes.
The Biochemical journal 2000;352 Pt 3():773-81.
2000: Monica Fengsrud; E S Erichsen; TO Berg; Camilla Raiborg; Per O Seglen
Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy.
European journal of cell biology 2000;79(12):871-82.
2000: H Blankson; E M Grotterød; Per O Seglen
Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin.
Cell death and differentiation 2000;7(8):739-46.
1998: A L Kovács; P B Gordon; E M Grotterød; Per O Seglen
Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP.
Biological chemistry 1998;379(11):1341-7.
1998: Per E Strømhaug; TO Berg; Monica Fengsrud; Per O Seglen
Purification and characterization of autophagosomes from rat hepatocytes.
The Biochemical journal 1998;335 ( Pt 2)():217-24.
1998: E Rundén; Per O Seglen; Finn-Mogens Haug; Ole Petter Ottersen; Tadeusz Wieloch; Mehrdad Shamloo; JH Laake
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7296-305.
1998: Hamid R Samari; Per O Seglen
Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase.
The Journal of biological chemistry 1998;273(37):23758-63.
1998: T O Berg; Monica Fengsrud; Per E Strømhaug; TO Berg; Per O Seglen
Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes.
The Journal of biological chemistry 1998;273(34):21883-92.
1997: Per O Seglen
DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival.
Cell biology and toxicology 1997;13(4-5):301-15.
1997: Per E Strømhaug; TO Berg; T Gjøen; Per O Seglen
Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes.
European journal of cell biology 1997;73(1):28-39.
1997: Per E Strømhaug; TO Berg; Kristian Berg; Per O Seglen
A novel method for the study of autophagy: destruction of hepatocytic lysosomes, but not autophagosomes, by the photosensitizing porphyrin tetra(4-sulphonatophenyl)porphine.
The Biochemical journal 1997;321 ( Pt 1)():217-25.
1996: I Holen; P B Gordon; Per E Strømhaug; Per O Seglen
Role of cAMP in the regulation of hepatocytic autophagy.
European journal of biochemistry / FEBS 1996;236(1):163-70.
1996: Per O Seglen; T O Berg; H Blankson; Monica Fengsrud; I Holen; Per E Strømhaug
Structural aspects of autophagy.
Advances in experimental medicine and biology 1996;389():103-11.
1995: Monica Fengsrud; N Roos; T Berg; W Liou; Jan W Slot; Per O Seglen
Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions.
Experimental cell research 1995;221(2):504-19.
1995: I Holen; P B Gordon; Per E Strømhaug; T O Berg; Monica Fengsrud; Andreas Brech; N Roos; T Berg; Per O Seglen
Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors.
The Biochemical journal 1995;311 ( Pt 1)():317-26.
1995: H Blankson; I Holen; Per O Seglen
Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid.
Experimental cell research 1995;218(2):522-30.
1995: I Holen; Per E Strømhaug; P B Gordon; Monica Fengsrud; T O Berg; Per O Seglen
Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins).
The Journal of biological chemistry 1995;270(21):12823-31.
1995: M Fosse; T O Berg; D S O'Reilly; Per O Seglen
Vanadate inhibition of hepatocytic autophagy. Calcium-modulated and osmolality-modulated antagonism by asparagine.
European journal of biochemistry / FEBS 1995;230(1):17-24.
1995: P B Gordon; I Holen; Per O Seglen
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid.
The Journal of biological chemistry 1995;270(11):5830-8.
1994: L Mossin; H Blankson; H Huitfeldt; Per O Seglen
Ploidy-dependent growth and binucleation in cultured rat hepatocytes.
Experimental cell research 1994;214(2):551-60.
1994: T O Berg; Per E Strømhaug; T Berg; Per O Seglen
Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate.
European journal of biochemistry / FEBS 1994;221(1):595-602.
1994: T S Jonassen; Per O Seglen; Trond Stokke
The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle.
Cell proliferation 1994;27(2):95-104.
1994: P Gerlyng; T Grotmol; Per O Seglen
Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation.
Carcinogenesis 1994;15(2):371-9.
1994: P Gerlyng; T Grotmol; Trond Stokke; Bjørn Erikstein; Per O Seglen
Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver.
Carcinogenesis 1994;15(1):53-9.
1993: P B Gordon; I Holen; M Fosse; J S Røtnes; Per O Seglen
Dependence of hepatocytic autophagy on intracellularly sequestered calcium.
The Journal of biological chemistry 1993;268(35):26107-12.
1993: G O Kisen; Luciana Tessitore; Paola Costelli; P B Gordon; P E Schwarze; Francesco M Baccino; Per O Seglen
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.
Carcinogenesis 1993;14(12):2501-5.
1993: P Gerlyng; A Abyholm; T Grotmol; Bjørn Erikstein; H S Huitfeldt; Trond Stokke; Per O Seglen
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth.
Cell proliferation 1993;26(6):557-65.
1993: I Holen; P B Gordon; Per O Seglen
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors.
European journal of biochemistry / FEBS 1993;215(1):113-22.
1993: Per E Strømhaug; Per O Seglen
Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes).
The Biochemical journal 1993;291 ( Pt 1)():115-21.
1992: P Gerlyng; T Grotmol; Bjørn Erikstein; Trond Stokke; Per O Seglen
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma.
Carcinogenesis 1992;13(10):1795-801.
1992: I Holen; P B Gordon; Per O Seglen
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.
The Biochemical journal 1992;284 ( Pt 3)():633-6.
1992: P B Gordon; H Høyvik; Per O Seglen
Prelysosomal and lysosomal connections between autophagy and endocytosis.
The Biochemical journal 1992;283 ( Pt 2)():361-9.
1992: Per O Seglen; P Bohley
Autophagy and other vacuolar protein degradation mechanisms.
Experientia 1992;48(2):158-72.
1992: P Bohley; Per O Seglen
Proteases and proteolysis in the lysosome.
Experientia 1992;48(2):151-7.
1992: P Gerlyng; Trond Stokke; H S Huitfeldt; T Stenersen; Håvard E Danielsen; T Grotmol; Per O Seglen
Analytical methods for the study of liver cell proliferation.
Cytometry 1992;13(4):404-15.
1991: H Høyvik; P B Gordon; T O Berg; Per E Strømhaug; Per O Seglen
Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine.
The Journal of cell biology 1991;113(6):1305-12.
1991: P E Schwarze; Gunnar Saeter; D Armstrong; R G Cameron; Ezio Laconi; Dittakavi S R Sarma; V Préat; Per O Seglen
Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments.
Carcinogenesis 1991;12(2):325-7.
1991: P B Gordon; I Holen; Per O Seglen
Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells.
Biomedica biochimica acta 1991;50(4-6):383-7.
1991: I Holen; P B Gordon; Per O Seglen
Role of cyclic nucleotides in the control of hepatic autophagy.
Biomedica biochimica acta 1991;50(4-6):389-92.
1991: Per O Seglen; P B Gordon; I Holen; H Høyvik
Hepatocytic autophagy.
Biomedica biochimica acta 1991;50(4-6):373-81.
1990: Per O Seglen; P B Gordon; I Holen
Non-selective autophagy.
Seminars in cell biology 1990;1(6):441-8.
1990: J Kopitz; G O Kisen; P B Gordon; P Bohley; Per O Seglen
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.
The Journal of cell biology 1990;111(3):941-53.
1990: Per O Seglen; P Gerlyng
Growth-related alterations during liver carcinogenesis: effect of promoters.
Environmental health perspectives 1990;88():197-205.
1990: Per O Seglen; Gunnar Saeter; P E Schwarze
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Hepatology (Baltimore, Md.) 1990;12(2):295-300.
1990: G Pichiri-Coni; P Coni; Ezio Laconi; P E Schwarze; Per O Seglen; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture.
Carcinogenesis 1990;11(6):981-4.
1990: P Gerlyng; Per O Seglen
Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth.
Bulletin du cancer 1990;77(5):461-6.
1990: Gunnar Saeter; Per O Seglen
Cell biology of hepatocarcinogenesis.
Critical reviews in oncogenesis 1990;1(4):437-66.
1989: P J Plomp; P B Gordon; Alfred J Meijer; H Høyvik; Per O Seglen
Energy dependence of different steps in the autophagic-lysosomal pathway.
The Journal of biological chemistry 1989;264(12):6699-704.
1989: Gunnar Saeter; P E Schwarze; Jahn M Nesland; Per O Seglen
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
British journal of cancer 1989;59(2):198-205.
1989: Per O Seglen; Hanne Skomedal; Gunnar Saeter; P E Schwarze; Jahn M Nesland
Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours.
Carcinogenesis 1989;10(1):21-5.
1989: P B Gordon; G O Kisen; A L Kovács; Per O Seglen
Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes.
Biochemical Society symposium 1989;55():129-43.
1988: Gunnar Saeter; Cha-Ze Lee; P E Schwarze; S Ous; D S Chen; J L Sung; Per O Seglen
Changes in ploidy distributions in human liver carcinogenesis.
Journal of the National Cancer Institute 1988;80(18):1480-5.
1988: Gunnar Saeter; P E Schwarze; Jahn M Nesland; N Juul; E O Pettersen; Per O Seglen
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.
Carcinogenesis 1988;9(6):939-45.
1988: Gunnar Saeter; P E Schwarze; Jahn M Nesland; Per O Seglen
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Carcinogenesis 1988;9(4):581-7.
1988: P B Gordon; Per O Seglen
Prelysosomal convergence of autophagic and endocytic pathways.
Biochemical and biophysical research communications 1988;151(1):40-7.
1987: P B Gordon; H Høyvik; Per O Seglen
Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes.
The Biochemical journal 1987;243(3):655-60.
1987: P J Plomp; E J Wolvetang; A K Groen; Alfred J Meijer; P B Gordon; Per O Seglen
Energy dependence of autophagic protein degradation in isolated rat hepatocytes.
European journal of biochemistry / FEBS 1987;164(1):197-203.
1987: Gunnar Saeter; P E Schwarze; Jahn M Nesland; Per O Seglen
Transplantation of preneoplastic rat hepatocytes by intraportal injection.
Toxicologic pathology 1987;15(1):78-81.
1986: H Høyvik; P B Gordon; Per O Seglen
Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway.
Experimental cell research 1986;166(1):1-14.
1986: Per O Seglen; P B Gordon; H Tolleshaug; H Høyvik
Use of [3H]raffinose as a specific probe of autophagic sequestration.
Experimental cell research 1986;162(1):273-7.
1986: Per O Seglen; P E Schwarze; Gunnar Saeter
Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis.
Toxicologic pathology 1986;14(3):342-8.
1986: Per O Seglen; P B Gordon; H Høyvik
Radiolabelled sugars as probes of hepatocytic autophagy.
Biomedica biochimica acta 1986;45(11-12):1647-56.
1985: P B Gordon; H Tolleshaug; Per O Seglen
Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes.
The Biochemical journal 1985;232(3):773-80.
1985: Per O Seglen; P B Gordon; H Tolleshaug; H Høyvik
Autophagy and protein degradation in isolated rat hepatocytes.
Biochemical Society transactions 1985;13(6):1007-10.
1985: P B Gordon; H Tolleshaug; Per O Seglen
Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods.
Experimental cell research 1985;160(2):449-58.
1985: P B Gordon; H Høyvik; Per O Seglen
Sequestration and hydrolysis of electroinjected [14C]lactose as a means of investigating autophagosome-lysosome fusion in isolated rat hepatocytes.
Progress in clinical and biological research 1985;180():475-7.
1985: Per O Seglen; P B Gordon; H Tolleshaug; H Høyvik
Pathways of intracellular sequestration and protein degradation in isolated rat hepatocytes.
Progress in clinical and biological research 1985;180():437-46.
1984: H Tolleshaug; P B Gordon; A E Solheim; Per O Seglen
Trapping of electro-injected [14C]sucrose by hepatocyte mitochondria: a mechanism for cellular autofiltration?
Biochemical and biophysical research communications 1984;119(3):955-61.
1981: A L Kovács; B Grinde; Per O Seglen
Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes.
Experimental cell research 1981;133(2):431-6.
1981: Per O Seglen; P B Gordon; B Grinde; A Solheim; A L Kovács; A Poli
Inhibitors and pathways of hepatocytic protein degradation.
Acta biologica et medica Germanica 1981;40(10-11):1587-98.