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Nabil Seidah

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Cell Line

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Minna T Jänis; Marcus E Kleber; Kim Ekroos; Reini Hurme; Terho Lehtimäki; Winfried März; Hannu Päivä; Annik Prat; Nabil G Seidah; Matti Suoniemi; Hung Xuan Ta; Kirill Tarasov; Reijo Laaksonen
Beyond LDL-C lowering: Distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency.
Dominique Julien Burri; Laura Cendron; Antonella Pasquato; Joel Ramos da Palma; Nabil G Seidah; Giuseppe Zanotti; Stefan Kunz
Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/Site 1 Protease (S1P).
Nabil G Seidah
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies.

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2013: Minna T Jänis; Marcus E Kleber; Kim Ekroos; Reini Hurme; Terho Lehtimäki; Winfried März; Hannu Päivä; Annik Prat; Nabil G Seidah; Matti Suoniemi; Hung Xuan Ta; Kirill Tarasov; Reijo Laaksonen
Beyond LDL-C lowering: Distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency.
Atherosclerosis 2013;228(2):380-5.
2013: Dominique Julien Burri; Laura Cendron; Antonella Pasquato; Joel Ramos da Palma; Nabil G Seidah; Giuseppe Zanotti; Stefan Kunz
Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/Site 1 Protease (S1P).
Journal of virology 2013;87(11):6406-14.
2013: Nabil G Seidah
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies.
Current pharmaceutical design 2013;19(17):3161-72.
2013: Emile Levy; Daniel Ménard; Alain Théophile Sane; Nabil G Seidah; Schohraya Spahis; Sabrina Yara; Jean-François Beaulieu; Ali Ben Djoudi Ouadda; Patrick Couture; Lea Emonnot; Carole Garofalo; Émilie Grenier; Mounib Elchebly
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells.
Atherosclerosis 2013;227(2):297-306.
2013: Steve Poirier; Peter Schu; Ta-Yuan Chang; William S Garver; Gaétan Mayer; Stephanie R Murphy; Nabil G Seidah
The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins.
Traffic (Copenhagen, Denmark) 2013;14(4):458-69.
2013: Bryan Krastins; Vathany Kulasingam; Kaj Blennow; Gregory Byram; Lewis Couchman; Benoit Coulombe; Bruno Darbouret; Alejandra Garces; Johan Gobom; Urban A Kiernan; Caje Moniz; Dobrin Nedelkov; Randall Nelson; Eric E Niederkofler; Josef Pannee; Joëlle R Pérusse; Scott Peterman; Erik Portelius; Amol Prakash; David A Sarracino; Nabil G Seidah; Jennifer N Sutton; Gouri Vadali; Maryann S Vogelsang; Mary F Lopez
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum.
Clinical biochemistry 2013;46(6):399-410.
2013: Maryssa Canuel; Eustache Paramithiotis; Annik Prat; Marie-Claude Asselin; Xiaowei Sun; Nabil G Seidah
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1).
PloS one 2013;8(5):e64145.
2013: Heiner K. Berthold; Suzanne Benjannet; Nabil G Seidah; Ioanna Gouni-Berthold
Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels.
PloS one 2013;8(3):e60095.
2013: Daniel Fantus; Zuhier Awan; Nabil G Seidah; Jacques Genest
Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor.
Atherosclerosis 2013;226(1):9-15.
2012: Yascara Grisel Luna Saavedra; Robert Day; Nabil G Seidah
The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.
The Journal of biological chemistry 2012;287(52):43492-501.
2012: Jérémy Besnard; G Richard Bickerton; Daniel B Constam; Ian H Gilbert; Keren Abecassis; Xi-Ping Huang; Suzanne Norval; Annik Prat; Kevin D Read; Ramona M Rodriguiz; Bryan L Roth; Gian Filippo Ruda; Maria F Sassano; Nabil G Seidah; Vincent Setola; Antony I Shin; Frederick R C Simeons; Laste Stojanovski; Lauren A Webster; William C Wetsel; Andrew L Hopkins
Automated design of ligands to polypharmacological profiles.
Nature 2012;492(7428):215-20.
2012: Xiaowei Sun; Nabil G Seidah; Robert Day; Rachid Essalmani; Abdel-Majid Khatib; Annik Prat
Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver.
Neoplasia (New York, N.Y.) 2012;14(12):1122-31.
2012: Deborah Maret; Emad Seyed Sadr; Mohamad Seyed Sadr; David R Colman; Rolando F Del Maestro; Nabil G Seidah
Opposite roles of furin and PC5A in N-cadherin processing.
Neoplasia (New York, N.Y.) 2012;14(10):880-92.
2012: Suzanne Benjannet; Michel Chrétien; Josée Hamelin; Nabil G Seidah
Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.
The Journal of biological chemistry 2012;287(40):33745-55.
2012: WooJin Kim; Anton J M Roebroek; Nabil G Seidah; Dorota Szumska; Shoumo Bhattacharya; John W M Creemers; Pedro D'Orleans-Juste; Rachid Essalmani; Annik Prat
Loss of endothelial furin leads to cardiac malformation and early postnatal death.
Molecular and cellular biology 2012;32(17):3382-91.
2012: Marianne Abifadel; Suzanne Benjannet; Dominique Bonnefont-Rousselot; Eric Bruckert; Valérie Carreau; Alain Carrié; John Chapman; Philippe Couvert; Maryse Guerin; Josée Hamelin; Zélie Julia; Wilfried Le Goff; Olivier Meilhac; Jean-Baptiste Michel; Annik Prat; Jean-Pierre Rabès; Nabil G Seidah; Laurent Tosolini; Mathilde Varret; catherine boileau
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.
Atherosclerosis 2012;223(2):394-400.
2012: Matthieu Blanchet; Nabil G Seidah; Patrick Labonté
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication.
Antiviral research 2012;95(2):159-66.
2012: Nabil G Seidah; Annik Prat
The biology and therapeutic targeting of the proprotein convertases.
Nature reviews. Drug discovery 2012;11(5):367-83.
2012: Dominique Julien Burri; Giulia Pasqual; Antonella Pasquato; Cylia Rochat; Nabil G Seidah; Stefan Kunz
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.
Journal of virology 2012;86(9):4935-46.
2012: Sarah Refaie; michel salzet; Nabil G Seidah; Donald F Steiner; Xiaorong Zhu; Roxane Desjardins; Pedro D'Orléans-Juste; Hugo Gagnon; Sandra Gagnon; Claude Lazure; François D'Anjou; Robert Day
Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
The Journal of biological chemistry 2012;287(18):14703-17.
2012: Johann Guillemot; Marc Klein; Hervé Lefebvre; M Montéro-Hadjadje; Mihaela Muresan; Aurélia Ravni; Nabil G Seidah; Erwan Thouennon; Virginie Vallet-Erdtmann; Youssef Anouar; M Guérin; Laurent Yon
Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66.
Journal of molecular endocrinology 2012;48(2):115-27.
2012: Caroline Richard; Nabil G Seidah; Alice H Lichtenstein; Suzanne Benjannet; Patrick Couture; Sophie Desroches; Benoît Lamarche
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome.
The British journal of nutrition 2012;107(5):705-11.
2012: Maxime Denis; Dany Gauthier; Claude Lazure; Jadwiga Marcinkiewicz; Steve Poirier; Nabil G Seidah; Ahmed Zaid; Annik Prat
Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice.
Circulation 2012;125(7):894-901.
2012: Nardos G Tassew; Nabil G Seidah; Jason Charish; Philippe P Monnier
SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.
Developmental cell 2012;22(2):391-402.
2012: Wesley F Zandberg; Nabil G Seidah; Ningguo Gao; Jayakanthan Kumarasamy; Mark A Lehrman; B Mario Pinto
5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation.
Chembiochem : a European journal of chemical biology 2012;13(3):392-401.
2012: Estelle Rousselet; Jasna Kriz; Nabil G Seidah
Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining.
Journal of visualized experiments : JoVE 2012;(69):.
2012: Nabil G Seidah; Hanny Wassef; Jean Davignon; Maxime Denis; Katherine A Hajjar; Claudio Mapelli; Bowman Miao; Rex Parker; Steve Poirier; Annik Prat; Gaétan Mayer
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.
PloS one 2012;7(7):e41865.
2011: Zuhier Awan; Dana Bailey; Maxime Denis; Adel Giaid; David Goltzman; Annik Prat; Nabil G Seidah; Jacques Genest
The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography.
Atherosclerosis 2011;219(2):455-62.
2011: Chiara Marchesi; Pierre Paradis; Ernesto L Schiffrin; Nabil G Seidah; Talin Ebrahimian; Rachid Essalmani; Eyal Leibovitz; Catherine A Lemarié; Annik Prat
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
Journal of molecular medicine (Berlin, Germany) 2011;89(11):1103-11.
2011: Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Nabil G Seidah; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.
Clinical chemistry 2011;57(10):1415-23.
2011: Wesley F Zandberg; Suzanne Benjannet; Josée Hamelin; B Mario Pinto; Nabil G Seidah
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1.
Glycobiology 2011;21(10):1290-300.
2011: Xiaowei Sun; Delia Susan-Resiga; Rachid Essalmani; Annik Prat; Nabil G Seidah
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
The Journal of biological chemistry 2011;286(33):29063-73.
2011: Antonella Pasquato; Nabil G Seidah; Esther Gomez-Ibarlucea Traba; Dominique Julien Burri; Layane Hanna-El-Daher; Stefan Kunz
Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease.
Virology 2011;417(1):18-26.
2011: Delia Susan-Resiga; Dorota Szumska; Marie-Claude Asselin; Suzanne Benjannet; Shoumo Bhattacharya; Ann Chamberland; Daniel Constam; Robert Day; Rachid Essalmani; Josée Hamelin; Annik Prat; Nabil G Seidah
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.
The Journal of biological chemistry 2011;286(26):22785-94.
2011: Estelle Rousselet; Ann Zhou; Mary E Hatten; Jasna Kriz; Jadwiga Marcinkiewicz; Annik Prat; Nabil G Seidah
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.
Journal of lipid research 2011;52(7):1383-91.
2011: Nicholas Denis; Heather Palmer-Smith; Fred Elisma; Alia Busuttil; Theodore Glenn Wright; Maroun Bou Khalil; Annik Prat; Nabil G Seidah; Michel Chrétien; Janice Mayne; Daniel Figeys
Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells.
Journal of proteome research 2011;10(4):2011-26.
2011: Anna Roubtsova; Mercedes Nancy Munkonda; Zuhier Awan; Jadwiga Marcinkiewicz; Ann Chamberland; Claude Lazure; Katherine Cianflone; Nabil G Seidah; Annik Prat
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):785-91.
2011: Estelle Rousselet; Suzanne Benjannet; Edwidge Marcinkiewicz; Marie-Claude Asselin; Claude Lazure; Nabil G Seidah
Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
The Journal of biological chemistry 2011;286(11):9185-95.
2011: Nabil G Seidah
What lies ahead for the proprotein convertases?
Annals of the New York Academy of Sciences 2011;1220():149-61.
2011: A Tremblay; Benoît Lamarche; Valéry Lemelin; Lizbeth Hoos; Suzanne Benjannet; Nabil G Seidah; Harry R Davis; Patrick Couture
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men.
Journal of lipid research 2011;52(3):558-65.
2011: Rachid Essalmani; Delia Susan-Resiga; Ann Chamberland; Marianne Abifadel; John W Creemers; catherine boileau; Nabil G Seidah; Annik Prat
In vivo evidence that furin from hepatocytes inactivates PCSK9.
The Journal of biological chemistry 2011;286(6):4257-63.
2011: Estelle Rousselet; Suzanne Benjannet; Josée Hamelin; Maryssa Canuel; Nabil G Seidah
The proprotein convertase PC7: unique zymogen activation and trafficking pathways.
The Journal of biological chemistry 2011;286(4):2728-38.
2011: Jeff P Gorski; Nichole Huffman; Sridar Chittur; Ronald J Midura; Claudine Black; Julie Oxford; Nabil G Seidah
Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.
The Journal of biological chemistry 2011;286(3):1836-49.
2011: Annik Prat; Ram M Sairam; Nabil G Seidah; Maik Behrendt; Sebastien Boridy; Edwige Marcinkiewicz; Dusica Maysinger
A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy.
Journal of aging research 2011;2011():251517.
2010: Suzanne Benjannet; Yascara Grisel Luna Saavedra; Josée Hamelin; Marie-Claude Asselin; Rachid Essalmani; Antonella Pasquato; Peter Lemaire; Gerald Duke; Bowman Miao; Franck Duclos; Rex Parker; Gaétan Mayer; Nabil G Seidah
Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events.
The Journal of biological chemistry 2010;285(52):40965-78.
2010: Deborah Maret; Eugenia Gruzglin; Mohamad Seyed Sadr; Vincent Siu; Weisong Shan; Alexander W Koch; Nabil G Seidah; Rolando F Del Maestro; David R Colman
Surface expression of precursor N-cadherin promotes tumor cell invasion.
Neoplasia (New York, N.Y.) 2010;12(12):1066-80.
2010: Babykumari P Chitramuthu; David C Baranowski; Benoît Cadieux; Estelle Rousselet; Nabil G Seidah; Hugh P J Bennett
Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(11):2933-46.
2010: Jean Davignon; Geneviève Dubuc; Nabil G Seidah
The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis.
Current atherosclerosis reports 2010;12(5):308-15.
2010: Bin Dong; Minhao Wu; Hai Li; Fredric B Kraemer; Khosrow Adeli; Nabil G Seidah; Sahng Wook Park; Jingwen Liu
Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters.
Journal of lipid research 2010;51(6):1486-95.
2010: Emile Levy; Geneviève Lalonde; Edgard Delvin; Mounib Elchebly; Louis P Précourt; Nabil G Seidah; Schohraya Spahis; Rémi Rabasa-Lhoret; Ehud Ziv
Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus.
Endocrinology 2010;151(3):958-70.
2010: Majambu Mbikay; Francine Sirois; Janice Mayne; Gen-Sheng Wang; Andrew Chen; Thilina Dewpura; Annik Prat; Nabil G Seidah; Michel Chretien; Fraser W Scott
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.
FEBS letters 2010;584(4):701-6.
2010: Elena Y Bryleva; Maximillian A Rogers; Catherine C Y Chang; Floyd Buen; Brent T Harris; Estelle Rousselet; Nabil G Seidah; Salvatore Oddo; Frank M LaFerla; Thomas A Spencer; William F Hickey; Ta-Yuan Chang
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3081-6.
2010: Abdel-Majid Khatib; Rachid Lahlil; Nathalie Scamuffa; Marie-Andrée Akimenko; Sylvain Ernest; Abdderahim Lomri; Claude Lalou; Nabil G Seidah; Bruno O Villoutreix; Fabien Calvo; Geraldine Siegfried
Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.
PloS one 2010;5(7):e11438.
2010: Nidhi Gupta; Niels Fisker; Marie-Claude Asselin; Marie Lindholm; Christoph Rosenbohm; Henrik Ørum; Joacim Elmén; Nabil G Seidah; Ellen Marie Straarup
A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.
PloS one 2010;5(5):e10682.
2010: Geneviève Dubuc; Michel Tremblay; Guillaume Paré; Hélène Jacques; Josée Hamelin; Suzanne Benjannet; Lucie Boulet; Jacques Genest; Lise Bernier; Nabil G Seidah; Jean Davignon
A new method for measurement of total plasma PCSK9: clinical applications.
Journal of lipid research 2010;51(1):140-9.
2009: Steve Poirier; Gaetan Mayer; Viviane Poupon; Peter S McPherson; Roxane Desjardins; Kevin Ly; Marie-Claude Asselin; Robert Day; Franck J Duclos; Mark Witmer; Rex Parker; Annik Prat; Nabil G Seidah
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.
The Journal of biological chemistry 2009;284(42):28856-64.
2009: Iulia Iatan; Zari Dastani; Ron Do; Daphna Weissglas-Volkov; Isabelle L Ruel; Jenny C Lee; Adriana Huertas-Vazquez; Marja-Riitta Taskinen; Annik Prat; Nabil G Seidah; Päivi Pajukanta; James C Engert; Jacques Genest
Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels.
Circulation. Cardiovascular genetics 2009;2(5):467-75.
2009: Patrick Labonté; Syntia Begley; Carl Guévin; Marie-Claude Asselin; Nasha Nassoury; Gaetan Mayer; Annik Prat; Nabil G Seidah
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression.
Hepatology (Baltimore, Md.) 2009;50(1):17-24.
2009: François Leblond; Nabil G Seidah; Louis-Philippe Précourt; Edgard Delvin; Michel Dominguez; Emile Levy
Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G805-15.
2009: Kulandaivelu S Vetrivel; Xavier Meckler; Ying Chen; Phuong D Nguyen; Nabil G Seidah; Robert Vassar; Philip C Wong; Masaki Fukata; Maria Z Kounnas; Gopal Thinakaran
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
The Journal of biological chemistry 2009;284(6):3793-803.
2009: Xiaowei Sun; Rachid Essalmani; Nabil G Seidah; Annik Prat
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
Molecular cancer 2009;8():73.
2009: Nabil G Seidah
PCSK9 as a therapeutic target of dyslipidemia.
Expert opinion on therapeutic targets 2009;13(1):19-28.
2009: Jeff P Gorski; Nichole Huffman; Chaoying Cui; Ellen P Henderson; Ronald J Midura; Nabil G Seidah
Potential role of proprotein convertase SKI-1 in the mineralization of primary bone.
Cells, tissues, organs 2009;189(1-4):25-32.
2008: Gaetan Mayer; Steve Poirier; Nabil G Seidah
Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.
The Journal of biological chemistry 2008;283(46):31791-801.
2008: Patrick Labonté; Nabil G Seidah
Emerging viruses: risk of pandemic.
Expert review of anti-infective therapy 2008;6(5):581-3.
2008: Michel Chrétien; Nabil G Seidah; Ajoy Basak; Majambu Mbikay
Proprotein convertases as therapeutic targets.
Expert opinion on therapeutic targets 2008;12(10):1289-300.
2008: Simona Ozden; Marianne Lucas-Hourani; Pierre-Emmanuel Ceccaldi; Ajoy Basak; Menogh Valentine; Suzanne Benjannet; Josée Hamelin; Yves Jacob; Kamel Mamchaoui; Vincent Mouly; Philippe Desprès; Antoine Gessain; Gillian Butler-Browne; Michel Chrétien; Frédéric Tangy; Pierre-Olivier Vidalain; Nabil G Seidah
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.
The Journal of biological chemistry 2008;283(32):21899-908.
2008: Ahmed Zaid; Anna Roubtsova; Rachid Essalmani; Jadwiga Marcinkiewicz; Ann Chamberland; Josée Hamelin; Michel Tremblay; Hélène Jacques; Weijun Jin; Jean Davignon; Nabil G Seidah; Annik Prat
Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.
Hepatology (Baltimore, Md.) 2008;48(2):646-54.
2008: Thilina Dewpura; Angela Raymond; Josée Hamelin; Nabil G Seidah; Majambu Mbikay; Michel Chrétien; Janice Mayne
PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.
The FEBS journal 2008;275(13):3480-93.
2008: Antonella Pasquato; Nabil G Seidah
The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains.
Journal of molecular neuroscience : MN 2008;35(3):339-43.
2008: Dorota Szumska; Guido Pieles; Rachid Essalmani; Michal Bilski; Daniel Marie Laurent Mesnard; Kulvinder Kaur; Angela Franklyn; Kamel El Omari; Joanna Jefferis; Jamie Bentham; Jennifer M Taylor; Jurgen E Schneider; Sebastian J Arnold; Paul Johnson; Zuzanna Tymowska-Lalanne; David K Stammers; Kieran Clarke; Stefan Neubauer; Andrew Morris; Steve D Brown; Charles Shaw-Smith; Armando Cama; Valeria Capra; Jiannis Ragoussis; Daniel Constam; Nabil G Seidah; Annik Prat; Shoumo Bhattacharya
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
Genes & development 2008;22(11):1465-77.
2008: Rachid Essalmani; Ahmed Zaid; Jadwiga Marcinkiewicz; Ann Chamberland; Antonella Pasquato; Nabil G Seidah; Annik Prat
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5750-5.
2008: Yong Xiao; Gang Chen; Jonathan Richard; Nicole Rougeau; Hongshan Li; Nabil G Seidah; Eric A Cohen
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.
Virology 2008;372(2):384-97.
2008: Steve Poirier; Gaetan Mayer; Suzanne Benjannet; Eric Bergeron; Jadwiga Marcinkiewicz; Nasha Nassoury; Harald Mayer; Johannes Nimpf; Annik Prat; Nabil G Seidah
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.
The Journal of biological chemistry 2008;283(4):2363-72.
2008: Gaetan Mayer; Josée Hamelin; Marie-Claude Asselin; Antonella Pasquato; Edwidge Marcinkiewicz; Meiyi Tang; Siamak Tabibzadeh; Nabil G Seidah
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.
The Journal of biological chemistry 2008;283(4):2373-84.
2008: Nabil G Seidah; Gaetan Mayer; Ahmed Zaid; Estelle Rousselet; Nasha Nassoury; Steve Poirier; Rachid Essalmani; Annik Prat
The activation and physiological functions of the proprotein convertases.
The international journal of biochemistry & cell biology 2008;40(6-7):1111-25.
2008: Nathalie Scamuffa; Geraldine Siegfried; Yannick Bontemps; Liming Ma; Ajoy Basak; Ghislaine Cherel; Fabien Calvo; Nabil G Seidah; Abdel-Majid Khatib
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
The Journal of clinical investigation 2008;118(1):352-63.
2007: Antonella Pasquato; Monica Dettin; Ajoy Basak; Roberta Gambaretto; L Tonin; Nabil G Seidah; Carlo Di Bello
Heparin enhances the furin cleavage of HIV-1 gp160 peptides.
FEBS letters 2007;581(30):5807-13.
2007: Aloys De Windt; MYRIAM RAI; Lise Bernier; Karin M Thelen; Juhani T Soini; Chantal Lefebvre; Satyan Chintawar; Jacques Lavigne; Lilli Saarinen; Leena Kytömäki; Jon Scott Munzer; Dieter Lütjohann; Massimo Pandolfo; Jean Davignon; Nabil G Seidah; Reijo Laaksonen
Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.
DNA and cell biology 2007;26(11):765-72.
2007: Marion Lapierre; Geraldine Siegfried; Nathalie Scamuffa; Yannick Bontemps; Fabien Calvo; Nabil G Seidah; Abdel-Majid Khatib
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Cancer research 2007;67(19):9030-4.
2007: Janice Mayne; Angela Raymond; Anna Chaplin; Marion Cousins; Nadine Kaefer; Charles Gyamera-Acheampong; Nabil G Seidah; Majambu Mbikay; Michel Chrétien; Teik Chye Ooi
Plasma PCSK9 levels correlate with cholesterol in men but not in women.
Biochemical and biophysical research communications 2007;361(2):451-6.
2007: Philomena Pullikotil; Suzanne Benjannet; Janice Mayne; Nabil G Seidah
The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.
The Journal of biological chemistry 2007;282(37):27402-13.
2007: Jimmy D Dikeakos; Chantal Mercure; Marie-Josée Lacombe; Nabil G Seidah; Timothy L Reudelhuber
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
The FEBS journal 2007;274(16):4094-102.
2007: Nabil G Seidah; Annik Prat
The proprotein convertases are potential targets in the treatment of dyslipidemia.
Journal of molecular medicine (Berlin, Germany) 2007;85(7):685-96.
2007: Majambu Mbikay; Gilles Croissandeau; Francine Sirois; Younes Anini; Janice Mayne; Nabil G Seidah; Michel Chrétien
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.
Developmental biology 2007;306(2):584-98.
2007: Nasha Nassoury; Daniel A Blasiole; Angie Tebon Oler; Suzanne Benjannet; Josée Hamelin; Poupon Viviane; Peter S McPherson; Alan D Attie; Annik Prat; Nabil G Seidah
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Traffic (Copenhagen, Denmark) 2007;8(6):718-32.
2007: Linda O Tremblay; Erzsebet Nagy Kovács; Eugene Daniels; Nyet Kui Wong; Mark Sutton-Smith; Howard R Morris; Anne Dell; Edwige Marcinkiewicz; Nabil G Seidah; Colin McKerlie; Annette Herscovics
Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation.
The Journal of biological chemistry 2007;282(4):2558-66.
2007: Majambu Mbikay; Janice Mayne; Nabil G Seidah; Michel Chrétien
Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.
Medical hypotheses 2007;69(5):1010-7.
2007: Jodie P Goodridge; Louise J Lathbury; Noriko K Steiner; Christine N Shulse; Philomena Pullikotil; Nabil G Seidah; Carolyn K Hurley; Frank T Christiansen; Campbell S Witt
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells.
European journal of immunology 2007;37(1):199-211.
2006: Suzanne Benjannet; David Rhainds; Josée Hamelin; Nasha Nassoury; Nabil G Seidah
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.
The Journal of biological chemistry 2006;281(41):30561-72.
2006: Gilles Croissandeau; Flora Wahnon; Kiran Yashpal; Nabil G Seidah; Terence J Coderre; Michel Chrétien; Majambu Mbikay
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.
Neuroscience letters 2006;406(1-2):71-5.
2006: Nathalie Scamuffa; Fabien Calvo; Michel Chrétien; Nabil G Seidah; Abdel-Majid Khatib
Proprotein convertases: lessons from knockouts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):1954-63.
2006: Antonella Pasquato; Philomena Pullikotil; Marie-Claude Asselin; Manuela Vacatello; Livio Paolillo; Francesca Ghezzo; Federica Basso; Carlo Di Bello; Monica Dettin; Nabil G Seidah
The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors.
The Journal of biological chemistry 2006;281(33):23471-81.
2006: Johann Guillemot; Laure Barbier; Erwan Thouennon; Virginie Vallet-Erdtmann; Maite Montero-Hadjadje; Hervé Lefebvre; Marc Klein; Mihaela Muresan; Pierre-François Plouin; Nabil G Seidah; Hubert Vaudry; Youssef Anouar; Laurent Yon
Expression and processing of the neuroendocrine protein secretogranin II in benign and malignant pheochromocytomas.
Annals of the New York Academy of Sciences 2006;1073():527-32.
2006: Steve Poirier; Annik Prat; Edwige Marcinkiewicz; Joanne Paquin; Babykumari P Chitramuthu; David Baranowski; Benoit Cadieux; Hugh P J Bennett; Nabil G Seidah
Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.
Journal of neurochemistry 2006;98(3):838-50.
2006: Nabil G Seidah; Abdel-Majid Khatib; Annik Prat
The proprotein convertases and their implication in sterol and/or lipid metabolism.
Biological chemistry 2006;387(7):871-7.
2006: Nabil G Seidah
Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases.
The Biochemical journal 2006;393(Pt 2):e1-3.
2006: Rachid Essalmani; Josée Hamelin; Jadwiga Marcinkiewicz; Ann Chamberland; Majambu Mbikay; Michel Chrétien; Nabil G Seidah; Annik Prat
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.
Molecular and cellular biology 2006;26(1):354-61.
2005: Weijun Jin; Ilia V Fuki; Nabil G Seidah; Suzanne Benjannet; Jane M Glick; Daniel J Rader
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.
The Journal of biological chemistry 2005;280(44):36551-9.
2005: Nadia Nour; Gaetan Mayer; John S Mort; Alexandre Salvas; Majambu Mbikay; Charlotte J Morrison; Christopher M Overall; Nabil G Seidah
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.
Molecular biology of the cell 2005;16(11):5215-26.
2005: Alexandre Salvas; Suzanne Benjannet; Timothy L Reudelhuber; Michel Chrétien; Nabil G Seidah
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.
FEBS letters 2005;579(25):5621-5.
2005: Geraldine Siegfried; Ajoy Basak; Wendy Prichett-Pejic; Nathalie Scamuffa; Liming Ma; Suzanne Benjannet; John P Veinot; Fabien Calvo; Nabil G Seidah; Abdel-Majid Khatib
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.
Oncogene 2005;24(46):6925-35.
2005: Mauro Costa-Mattioli; Delphine Gobert; Heather P Harding; Barbara Herdy; Mounia Azzi; Martin Bruno; Michael Bidinosti; Cyrinne Ben Mamou; Edwige Marcinkiewicz; Madoka Yoshida; Hiroaki Imataka; A Claudio Cuello; Nabil G Seidah; Wayne S Sossin; Jean-Claude Lacaille; David Ron; Karim Nader; Nahum Sonenberg
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.
Nature 2005;436(7054):1166-73.
2005: Florent Lalanne; Gilles Lambert; Marcelo J A Amar; Maud Chétiveaux; Yassine Zaïr; Anne-Laure Jarnoux; Khadija Ouguerram; José Friburg; Nabil G Seidah; H Bryan Brewer; Michel Krempf; Philippe Costet
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.
Journal of lipid research 2005;46(6):1312-9.
2005: Philipp Stawowy; Heike Meyborg; Dietger Stibenz; Núbia Borges Pereira Stawowy; Mattias Roser; Usan Thanabalasingam; John P Veinot; Michel Chrétien; Nabil G Seidah; Eckart Fleck; Kristof Graf
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Circulation 2005;111(21):2820-7.
2005: Ricardo López de Cicco; Daniel E Bassi; Stanley Zucker; Nabil G Seidah; Andres J P Klein-Szanto
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Cancer research 2005;65(10):4162-71.
2005: Alan D Attie; Nabil G Seidah
Dual regulation of the LDL receptor--some clarity and new questions.
Cell metabolism 2005;1(5):290-2.
2005: Philipp Stawowy; Heike Kallisch; Núbia Borges Pereira Stawowy; Dietger Stibenz; John P Veinot; Michael Gräfe; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
Virchows Archiv : an international journal of pathology 2005;446(4):351-9.
2005: Eric Bergeron; Martin J Vincent; Louise Wickham; Josée Hamelin; Ajoy Basak; Stuart T Nichol; Michel Chrétien; Nabil G Seidah
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus.
Biochemical and biophysical research communications 2005;326(3):554-63.
2005: George N Tzimas; Eric Chevet; Sarah Jenna; Duc Thang Nguyên; Abdel-Majid Khatib; Victoria A Marcus; Yi Zhang; Michel Chrétien; Nabil G Seidah; Peter Metrakos
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.
BMC cancer 2005;5():149.
2005: Martin J Vincent; Eric Bergeron; Suzanne Benjannet; Bobbie R Erickson; Pierre E Rollin; Thomas G Ksiazek; Nabil G Seidah; Stuart T Nichol
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.
Virology journal 2005;2():69.
2005: Louise Wickham; Suzanne Benjannet; Edwige Marcinkiewicz; Michel Chretien; Nabil G Seidah
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
Journal of neurochemistry 2005;92(1):93-102.
2004: Suzanne Benjannet; James A Cromlish; Karidia Diallo; Michel Chrétien; Nabil G Seidah
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Biochemical and biophysical research communications 2004;325(1):235-42.
2004: Suzanne Benjannet; David Rhainds; Rachid Essalmani; Janice Mayne; Louise Wickham; Weijun Jin; Marie-Claude Asselin; Josée Hamelin; Mathilde Varret; Delphine Allard; Mélanie Trillard; Marianne Abifadel; Angie Tebon; Alan D Attie; Daniel J Rader; catherine boileau; Louise Brissette; Michel Chrétien; Annik Prat; Nabil G Seidah
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
The Journal of biological chemistry 2004;279(47):48865-75.
2004: Farhad Amiri; Agostino Virdis; Mario Fritsch Neves; Marc Iglarz; Nabil G Seidah; Rhian M Touyz; Timothy L Reudelhuber; Ernesto L Schiffrin
Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.
Circulation 2004;110(15):2233-40.
2004: John P Veinot; Wendy Prichett-Pejic; Pierre Picard; William Parks; Robert Schwartz; Nabil G Seidah; Michel Chretien
Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2004;13(5):241-50.
2004: Philipp Stawowy; Heike Kallisch; Adam Kilimnik; Christian Margeta; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.
Biochemical and biophysical research communications 2004;321(3):531-8.
2004: Rania Mouchantaf; Heather L Watt; Traian Sulea; Nabil G Seidah; Haydar Alturaihi; Yogesh C Patel; Ujendra Kumar
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
Regulatory peptides 2004;120(1-3):133-40.
2004: Geneviève Dubuc; Ann Chamberland; Hanny Wassef; Jean Davignon; Nabil G Seidah; Lise Bernier; Annik Prat
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1454-9.
2004: Philipp Stawowy; Christian Margeta; Heike Kallisch; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase.
Cardiovascular research 2004;63(1):87-97.
2004: Mimoun Nejjari; Virginie Berthet; Véronique Rigot; Sullivan Laforest; Marie-France Jacquier; Nabil G Seidah; Lionel Remy; Erik Bruyneel; Jean-Yves Scoazec; Jacques Marvaldi; José Luis
Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model.
The American journal of pathology 2004;164(6):1925-33.
2004: Philomena Pullikotil; Martin Vincent; Stuart T Nichol; Nabil G Seidah
Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.
The Journal of biological chemistry 2004;279(17):17338-47.
2004: Samuel F Posner; Charles A Vaslet; Michelle Jurofcik; Alisson Lee; Nabil G Seidah; Eduardo A Nillni
Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.
Endocrine 2004;23(2-3):199-213.
2004: Philipp Stawowy; Heike Kallisch; John P Veinot; Adam Kilimnik; Wendy Prichett; Stephan Goetze; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.
Circulation 2004;109(6):770-6.
2003: Andrew P Hibbert; Stephen J Morris; Nabil G Seidah; Richard A Murphy
Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway.
The Journal of biological chemistry 2003;278(48):48129-36.
2003: Tetsuya Okada; Kyosuke Haze; Satomi Nadanaka; Hiderou Yoshida; Nabil G Seidah; Yuko Hirano; Ryuichiro Sato; Manabu Negishi; Kazutoshi Mori
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.
The Journal of biological chemistry 2003;278(33):31024-32.
2003: Martin J Vincent; Angela J Sanchez; Bobbie R Erickson; Ajoy Basak; Michel Chretien; Nabil G Seidah; Stuart T Nichol
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.
Journal of virology 2003;77(16):8640-9.
2003: Eric Bergeron; Ajoy Basak; jeff Keyser; Nabil G Seidah
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.
The Biochemical journal 2003;373(Pt 2):475-84.
2003: Geraldine Siegfried; Ajoy Basak; James A Cromlish; Suzanne Benjannet; Jadwiga Marcinkiewicz; Michel Chrétien; Nabil G Seidah; Abdel-Majid Khatib
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
The Journal of clinical investigation 2003;111(11):1723-32.
2003: Marianne Abifadel; Mathilde Varret; Jean-Pierre Rabès; Delphine Allard; Khadija Ouguerram; Martine Devillers; Corinne Cruaud; Suzanne Benjannet; Louise Wickham; Danièle Erlich; Aurélie Derré; Ludovic Villéger; Michel Farnier; Isabel Beucler; Eric Bruckert; Jean CHAMBAZ; Bernard Chanu; Jean-Michel Lecerf; Gerald Luc; Philippe Moulin; Jean Weissenbach; Annick Prat; Michel Krempf; Claudine Junien; Nabil G Seidah; catherine boileau
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
Nature genetics 2003;34(2):154-6.
2003: Geraldine Siegfried; Abdel-Majid Khatib; Suzanne Benjannet; Michel Chrétien; Nabil G Seidah
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
Cancer research 2003;63(7):1458-63.
2003: Alfred Doblinger; Alexandra Becker; Nabil G Seidah; Andrea Laslop
Proteolytic processing of chromogranin A by the prohormone convertase PC2.
Regulatory peptides 2003;111(1-3):111-6.
2003: Ina Kalus; Birthe Schnegelsberg; Nabil G Seidah; Ralf Kleene; Melitta Schachner
The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.
The Journal of biological chemistry 2003;278(12):10381-8.
2003: Philipp Stawowy; Kristof Graf; Stephan Goetze; Mattias Roser; Michel Chrétien; Nabil G Seidah; Eckart Fleck; Mieczyslaw Marcinkiewicz
Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.
Histochemistry and cell biology 2003;119(3):239-45.
2003: Magali Conesa; Annik Prat; John S Mort; Jacques Marvaldi; Jean-Claude Lissitzky; Nabil G Seidah
Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.
The Biochemical journal 2003;370(Pt 2):703-11.
2003: Nabil G Seidah; Suzanne Benjannet; Louise Wickham; Jadwiga Marcinkiewicz; Stephanie Belanger Jasmin; Stefano Stifani; Ajoy Basak; Annik Prat; Michel Chretien
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):928-33.
2003: Nadia Nour; Ajoy Basak; Michel Chrétien; Nabil G Seidah
Structure-function analysis of the prosegment of the proprotein convertase PC5A.
The Journal of biological chemistry 2003;278(5):2886-95.
2002: Véronique Hospital; Eiichiro Nishi; Michael Klagsbrun; Paul Cohen; Nabil G Seidah; Annik Prat
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).
The Biochemical journal 2002;367(Pt 1):229-38.
2002: Pierre Villeneuve; Sylvain Feliciangeli; Gilles Croissandeau; Nabil G Seidah; Majambu Mbikay; Patrick Kitabgi; Alain Beaudet
Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.
Journal of neurochemistry 2002;82(4):783-93.
2002: Majambu Mbikay; Marie-Laure Raffin-Sanson; Francine Sirois; Luaba Kalenga; Michel Chrétien; Nabil G Seidah
Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.
Brain research. Molecular brain research 2002;102(1-2):35-47.
2002: Hannele Kangas; Nabil G Seidah; Tiina Paunio
Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(2):83-7.
2002: Abdel-Majid Khatib; Geraldine Siegfried; Michel Chrétien; Peter Metrakos; Nabil G Seidah
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.
The American journal of pathology 2002;160(6):1921-35.
2002: Haidy Tadros; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(2):109-11.
2002: Aram Elagoz; Suzanne Benjannet; Aida Mammarbassi; Louise Wickham; Nabil G Seidah
Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.
The Journal of biological chemistry 2002;277(13):11265-75.
2002: Gilles Croissandeau; Ajoy Basak; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.
Journal of cell science 2002;115(Pt 6):1203-11.
2002: Ajoy Basak; Michel Chrétien; Nabil G Seidah
A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus.
FEBS letters 2002;514(2-3):333-9.
2002: Nabil G Seidah; Annik Prat
Precursor convertases in the secretory pathway, cytosol and extracellular milieu.
Essays in biochemistry 2002;38():79-94.
2001: Abdel-Majid Khatib; Geraldine Siegfried; Annik Prat; J Luis; Michel Chrétien; Peter Metrakos; Nabil G Seidah
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.
The Journal of biological chemistry 2001;276(33):30686-93.
2001: Majambu Mbikay; Nabil G Seidah; Michel Chrétien
Neuroendocrine secretory protein 7B2: structure, expression and functions.
The Biochemical journal 2001;357(Pt 2):329-42.
2001: SJ Mowla; Hooman F Farhadi; S Pareek; J K Atwal; Stephen J Morris; Nabil G Seidah; Richard A Murphy
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.
The Journal of biological chemistry 2001;276(16):12660-6.
2001: Suzanne Benjannet; A Elagoz; Louise Wickham; M Mamarbachi; JS Munzer; Ajoy Basak; Claude Lazure; James A Cromlish; Sangram S Sisodia; F Checler; Michel Chrétien; Nabil G Seidah
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
The Journal of biological chemistry 2001;276(14):10879-87.
2001: Philipp Stawowy; Jadwiga Marcinkiewicz; Kristof Graf; Nabil G Seidah; Michel Chrétien; E Fleck; Mieczyslaw Marcinkiewicz
Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(3):323-32.
2001: Ajoy Basak; M Zhong; JS Munzer; Michel Chrétien; Nabil G Seidah
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides.
The Biochemical journal 2001;353(Pt 3):537-45.
2001: Eduardo A Nillni; F Aird; Nabil G Seidah; R B Todd; James I Koenig
PreproTRH(178-199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling.
Endocrinology 2001;142(2):896-906.
2000: I Jutras; Nabil G Seidah; Timothy L Reudelhuber
A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway.
The Journal of biological chemistry 2000;275(51):40337-43.
2000: Pierre Villeneuve; Nabil G Seidah; Alain Beaudet
Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain.
Neuroreport 2000;11(16):3443-7.
2000: Mieczyslaw Marcinkiewicz; Nabil G Seidah
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
Journal of neurochemistry 2000;75(5):2133-43.
2000: C Rovère; J S Mort; Michel Chrétien; Nabil G Seidah
Cathepsin-B fusion proteins misroute secretory protein partners such as the proprotein convertase PC2-7B2 complex toward the lysosomal degradation pathways.
Biochemical and biophysical research communications 2000;276(2):594-9.
2000: Pierre Villeneuve; Louise Lafortune; Nabil G Seidah; Patrick Kitabgi; Alain Beaudet
Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain.
The Journal of comparative neurology 2000;424(3):461-75.
2000: Guillaume Lesage; A Prat; J Lacombe; David Y Thomas; Nabil G Seidah; Guy Boileau
The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function.
Molecular biology of the cell 2000;11(6):1947-57.
2000: Hooman F Farhadi; SJ Mowla; Kevin Petrecca; Stephen J Morris; Nabil G Seidah; Richard A Murphy
Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4059-68.
2000: G Ghaddar; Andréa Frota Ruchon; Mélanie Carpentier; Mieczyslaw Marcinkiewicz; Nabil G Seidah; Philippe Crine; Luc DesGroseillers; Guy Boileau
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
The Biochemical journal 2000;347(Pt 2):419-29.
2000: Jean-Claude Lissitzky; José Luis; JS Munzer; Suzanne Benjannet; Fabrice Parat; Michel Chrétien; Jacques Marvaldi; Nabil G Seidah
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.
The Biochemical journal 2000;346 Pt 1():133-8.
2000: BB Touré; JS Munzer; Ajoy Basak; Suzanne Benjannet; J Rochemont; Claude Lazure; Michel Chrétien; Nabil G Seidah
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.
The Journal of biological chemistry 2000;275(4):2349-58.
1999: Nabil G Seidah; Michel Chrétien
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Brain research 1999;848(1-2):45-62.
1999: M Zhong; JS Munzer; Ajoy Basak; Suzanne Benjannet; SJ Mowla; jeff Keyser; Michel Chrétien; Nabil G Seidah
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.
The Journal of biological chemistry 1999;274(48):33913-20.
1999: Nabil G Seidah; Suzanne Benjannet; Josée Hamelin; Aida M Mamarbachi; Ajoy Basak; Jadwiga Marcinkiewicz; Majambu Mbikay; Michel Chrétien; Mieczyslaw Marcinkiewicz
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.
Annals of the New York Academy of Sciences 1999;885():57-74.
1999: Ajoy Basak; BB Touré; Claude Lazure; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Enzymic characterization in vitro of recombinant proprotein convertase PC4.
The Biochemical journal 1999;343 Pt 1():29-37.
1999: Lucie Canaff; Hugh P J Bennett; Y Hou; Nabil G Seidah; Geoffrey N Hendy
Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3.
Endocrinology 1999;140(8):3633-42.
1999: C Rovère; José Luis; Jean-Claude Lissitzky; Ajoy Basak; Jacques Marvaldi; Michel Chrétien; Nabil G Seidah
The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.
The Journal of biological chemistry 1999;274(18):12461-7.
1999: SJ Mowla; S Pareek; Hooman F Farhadi; Kevin Petrecca; JP Fawcett; Nabil G Seidah; Stephen J Morris; Wayne S Sossin; Richard A Murphy
Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):2069-80.
1999: Nabil G Seidah; SJ Mowla; Josée Hamelin; Aida M Mamarbachi; Suzanne Benjannet; BB Touré; Ajoy Basak; JS Munzer; Jadwiga Marcinkiewicz; M Zhong; J C Barale; Claude Lazure; Richard A Murphy; Michel Chrétien; Mieczyslaw Marcinkiewicz
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1321-6.
1999: Ajoy Basak; S Cooper; A G Roberge; U K Banik; Michel Chrétien; Nabil G Seidah
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.
The Biochemical journal 1999;338 ( Pt 1)():107-13.
1999: Pierre Villeneuve; Nabil G Seidah; Alain Beaudet
Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain.
Neuroscience 1999;92(2):641-54.
1998: A Boudreault; Dany Gauthier; N Rondeau; D Savaria; Nabil G Seidah; Michel Chrétien; Claude Lazure
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells.
Protein expression and purification 1998;14(3):353-66.
1998: S E Girardin; Suzanne Benjannet; J C Barale; Michel Chrétien; Nabil G Seidah
The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells.
FEBS letters 1998;431(3):333-8.
1998: Suzanne Benjannet; Aida M Mamarbachi; Josée Hamelin; D Savaria; JS Munzer; Michel Chrétien; Nabil G Seidah
Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity.
FEBS letters 1998;428(1-2):37-42.
1998: Nabil G Seidah; R Day; Mieczyslaw Marcinkiewicz; Michel Chrétien
Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins.
Annals of the New York Academy of Sciences 1998;839():9-24.
1998: Claude Lazure; Dany Gauthier; F Jean; A Boudreault; Nabil G Seidah; H P Bennett; G N Hendy
In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor.
The Journal of biological chemistry 1998;273(15):8572-80.
1998: Andrea Laslop; C Weiss; D Savaria; C Eiter; S A Tooze; Nabil G Seidah; H Winkler
Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases.
Journal of neurochemistry 1998;70(1):374-83.
1997: Suzanne Benjannet; D Savaria; Andrea Laslop; JS Munzer; Michel Chrétien; Mieczyslaw Marcinkiewicz; Nabil G Seidah
Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway.
The Journal of biological chemistry 1997;272(42):26210-8.
1997: Nabil G Seidah; Michel Chrétien
Eukaryotic protein processing: endoproteolysis of precursor proteins.
Current opinion in biotechnology 1997;8(5):602-7.
1997: J Lusson; Suzanne Benjannet; Josée Hamelin; D Savaria; Michel Chrétien; Nabil G Seidah
The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.
The Biochemical journal 1997;326 ( Pt 3)():737-44.
1997: P Schaner; R B Todd; Nabil G Seidah; Eduardo A Nillni
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
The Journal of biological chemistry 1997;272(32):19958-68.
1997: JS Munzer; Ajoy Basak; M Zhong; Aida M Mamarbachi; Josée Hamelin; D Savaria; Claude Lazure; G N Hendy; Suzanne Benjannet; Michel Chrétien; Nabil G Seidah
In vitro characterization of the novel proprotein convertase PC7.
The Journal of biological chemistry 1997;272(32):19672-81.
1997: Majambu Mbikay; Haidy Tadros; N Ishida; Charles P Lerner; E De Lamirande; A Chen; Mohamed El-Alfy; Y Clermont; Nabil G Seidah; Michel Chrétien; C Gagnon; Elizabeth M Simpson
Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6842-6.
1997: I Jutras; Nabil G Seidah; Timothy L Reudelhuber; V Brechler
Two activation states of the prohormone convertase PC1 in the secretory pathway.
The Journal of biological chemistry 1997;272(24):15184-8.
1997: Ajoy Basak; B Ernst; D Brewer; Nabil G Seidah; JS Munzer; Claude Lazure; Gilles Lajoie
Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1.
The journal of peptide research : official journal of the American Peptide Society 1997;49(6):596-603.
1997: Hooman F Farhadi; S Pareek; R Day; W Dong; Michel Chrétien; J J Bergeron; Nabil G Seidah; Richard A Murphy
Prohormone convertases in mouse submandibular gland: co-localization of furin and nerve growth factor.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(6):795-804.
1997: jeff Keyser; Suzanne Benjannet; D Savaria; Nabil G Seidah
Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160.
FEBS letters 1997;405(1):68-72.
1997: W Dong; B Seidel; M Marcinkiewicz; Michel Chrétien; Nabil G Seidah; Robert Day
Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):563-75.
1997: Majambu Mbikay; Francine Sirois; J Yao; Nabil G Seidah; Michel Chrétien
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
British journal of cancer 1997;75(10):1509-14.
1997: M Marcinkiewicz; T Nagao; R Day; Nabil G Seidah; Michel Chrétien; Massimo Avoli
Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression.
Neuroscience 1997;76(2):425-39.
1997: M Laframboise; Timothy L Reudelhuber; I Jutras; V Brechler; Nabil G Seidah; R Day; K W Gross; Christian Deschepper
Prorenin activation and prohormone convertases in the mouse As4.1 cell line.
Kidney international 1997;51(1):104-9.
1996: jeff Keyser; S Wouters; C Di Bello; Claude Lazure; Jean-Marie Ruysschaert; Nabil G Seidah
Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.
The Journal of biological chemistry 1996;271(48):30442-50.
1996: Chantal Mercure; I Jutras; R Day; Nabil G Seidah; Timothy L Reudelhuber
Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex.
Hypertension 1996;28(5):840-6.
1996: M Zhong; Suzanne Benjannet; Claude Lazure; S Munzer; Nabil G Seidah
Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform.
FEBS letters 1996;396(1):31-6.
1996: M Santavicca; A Noel; H Angliker; Isabelle Stoll; J P Segain; Patrick Anglard; M Chretien; Nabil G Seidah; P Basset
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases.
The Biochemical journal 1996;315 ( Pt 3)():953-8.
1996: Nabil G Seidah; Josée Hamelin; M Mamarbachi; W Dong; H Tardos; Majambu Mbikay; M Chretien; R Day
cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3388-93.
1996: Nabil G Seidah; Suzanne Benjannet; S Pareek; D Savaria; Josée Hamelin; B Goulet; J Laliberte; Claude Lazure; Michel Chrétien; R A Murphy
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
The Biochemical journal 1996;314 ( Pt 3)():951-60.
1996: F Vollenweider; Suzanne Benjannet; jeff Keyser; D Savaria; Claude Lazure; Gary Thomas; Michel Chrétien; Nabil G Seidah
Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.
The Biochemical journal 1996;314 ( Pt 2)():521-32.
1996: Nabil G Seidah; Suzanne Benjannet; S Pareek; Michel Chrétien; R A Murphy
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases.
FEBS letters 1996;379(3):247-50.
1996: Mieczyslaw Marcinkiewicz; Nabil G Seidah; Michel Chrétien
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues.
Acta neurobiologiae experimentalis 1996;56(1):287-98.
1995: Ajoy Basak; A Boudreault; A Chen; Michel Chrétien; Nabil G Seidah; Claude Lazure
Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(6):385-95.
1995: Majambu Mbikay; H Tadros; Nabil G Seidah; Elizabeth M Simpson
Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse chromosome 2.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(11):818-9.
1995: Aristea S Galanopoulou; Nabil G Seidah; Yogesh C Patel
Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule.
The Biochemical journal 1995;311 ( Pt 1)():111-8.
1995: Ajoy Basak; C Schmidt; A A Ismail; Nabil G Seidah; Michel Chrétien; Claude Lazure
Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases.
International journal of peptide and protein research 1995;46(3-4):228-37.
1995: F Jean; A Boudreault; Ajoy Basak; Nabil G Seidah; Claude Lazure
Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor.
The Journal of biological chemistry 1995;270(33):19225-31.
1995: N Brakch; Monica Dettin; Claudia Scarinci; Nabil G Seidah; Carlo Di Bello
Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1.
Biochemical and biophysical research communications 1995;213(1):356-61.
1995: Moise Bendayan; Daniela Malide; Ehud Ziv; E Levy; R Ben-Sasson; R Kalman; H Bar-On; Michel Chrétien; Nabil G Seidah
Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(8):771-84.
1995: P E Milhiet; S Chevallier; D Corbeil; Nabil G Seidah; Philippe Crine; Guy Boileau
Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin.
The Biochemical journal 1995;309 ( Pt 2)():683-8.
1995: Aristea S Galanopoulou; Nabil G Seidah; Yogesh C Patel
Direct role of furin in mammalian prosomatostatin processing.
The Biochemical journal 1995;309 ( Pt 1)():33-40.
1995: D Joshi; M M Miller; Nabil G Seidah; R Day
Age-related alterations in the expression of prohormone convertase messenger ribonucleic acid (mRNA) levels in hypothalamic proopiomelanocortin mRNA neurons in the female C57BL/6J mouse.
Endocrinology 1995;136(6):2721-9.
1995: F Jean; Ajoy Basak; J DiMaio; Nabil G Seidah; Claude Lazure
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
The Biochemical journal 1995;307 ( Pt 3)():689-95.
1995: Suzanne Benjannet; D Savaria; Michel Chrétien; Nabil G Seidah
7B2 is a specific intracellular binding protein of the prohormone convertase PC2.
Journal of neurochemistry 1995;64(5):2303-11.
1995: Geoffrey N Hendy; Hugh P J Bennett; B F Gibbs; C Lazure; R Day; Nabil G Seidah
Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study.
The Journal of biological chemistry 1995;270(16):9517-25.
1995: Suzanne Benjannet; J Lusson; Josée Hamelin; D Savaria; Michel Chrétien; Nabil G Seidah
Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex.
FEBS letters 1995;362(2):151-5.
1995: N Brakch; Aristea S Galanopoulou; Yogesh C Patel; Guy Boileau; Nabil G Seidah
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
FEBS letters 1995;362(2):143-6.
1995: Michel Chrétien; Majambu Mbikay; L Gaspar; Nabil G Seidah
Proprotein convertases and the pathophysiology of human diseases: prospective considerations.
Proceedings of the Association of American Physicians 1995;107(1):47-66.
1995: J Hoflehner; Ursula Eder; Andrea Laslop; Nabil G Seidah; Reiner Fischer-Colbrie; H Winkler
Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin.
FEBS letters 1995;360(3):294-8.
1995: Majambu Mbikay; Nabil G Seidah; Michel Chrétien; Elizabeth M Simpson
Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.
Genomics 1995;26(1):123-9.
1995: G Beaubien; M K Schäfer; E Weihe; W Dong; Michel Chrétien; Nabil G Seidah; R Day
The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates.
Cell and tissue research 1995;279(3):539-49.
1995: I De Bie; D Savaria; A J Roebroek; R Day; Claude Lazure; W J Van de Ven; Nabil G Seidah
Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2.
The Journal of biological chemistry 1995;270(3):1020-8.
1995: Daniela Malide; Nabil G Seidah; Michel Chrétien; Moise Bendayan
Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(1):11-9.
1994: Nabil G Seidah; J C Barale; Mieczyslaw Marcinkiewicz; M G Mattei; R Day; Michel Chrétien
The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.
DNA and cell biology 1994;13(12):1163-80.
1994: Timothy L Reudelhuber; D Ramla; L Chiu; Chantal Mercure; Nabil G Seidah
Proteolytic processing of human prorenin in renal and non-renal tissues.
Kidney international 1994;46(6):1522-4.
1994: M Marcinkiewicz; D Ramla; Nabil G Seidah; Michel Chrétien
Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
Endocrinology 1994;135(4):1651-60.
1994: Ajoy Basak; F Jean; Nabil G Seidah; Claude Lazure
Design and synthesis of novel inhibitors of prohormone convertases.
International journal of peptide and protein research 1994;44(3):253-61.
1994: L Paquet; F Bergeron; A Boudreault; Nabil G Seidah; Michel Chrétien; Majambu Mbikay; Claude Lazure
The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.
The Journal of biological chemistry 1994;269(30):19279-85.
1994: Andrea Laslop; Sushil K Mahata; M Wolkersdorfer; Manjula Mahata; M Srivastava; Nabil G Seidah; Reiner Fischer-Colbrie; H Winkler
Large dense-core vesicles in rat adrenal after reserpine: levels of mRNAs of soluble and membrane-bound constituents in chromaffin and ganglion cells indicate a biosynthesis of vesicles with higher secretory quanta.
Journal of neurochemistry 1994;62(6):2448-56.
1994: N Ftouhi; R Day; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Gene organization of the mouse pro-hormone and pro-protein convertase PC1.
DNA and cell biology 1994;13(4):395-407.
1994: Majambu Mbikay; M L Raffin-Sanson; H Tadros; F Sirois; Nabil G Seidah; M Chretien
Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms.
Genomics 1994;20(2):231-7.
1994: A Dupuy; Iris Lindberg; Y Zhou; Huda Akil; Claude Lazure; Michel Chrétien; Nabil G Seidah; R Day
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue.
FEBS letters 1994;337(1):60-5.
1994: Nabil G Seidah; Michel Chrétien
Pro-protein convertases of subtilisin/kexin family.
Methods in enzymology 1994;244():175-88.
1993: Suzanne Benjannet; N Rondeau; L Paquet; A Boudreault; Claude Lazure; Michel Chrétien; Nabil G Seidah
Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
The Biochemical journal 1993;294 ( Pt 3)():735-43.
1993: Nabil G Seidah; Robert Day; Michel Chrétien
The family of pro-hormone and pro-protein convertases.
Biochemical Society transactions 1993;21 ( Pt 3)(3):685-91.
1993: J Lusson; D Vieau; Josée Hamelin; R Day; Michel Chrétien; Nabil G Seidah
cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6691-5.
1993: F Jean; Ajoy Basak; N Rondeau; Suzanne Benjannet; Geoffrey N Hendy; Nabil G Seidah; Michel Chrétien; Claude Lazure
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.
The Biochemical journal 1993;292 ( Pt 3)():891-900.
1993: A Basak; X W Yuan; R Harris; Nabil G Seidah; Michel Chrétien
Synthesis of the segment (11-23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328-343) to high-molecular-mass kininogen.
Journal of chromatography 1993;615(2):251-64.
1993: M Marcinkiewicz; Robert Day; Nabil G Seidah; Michel Chrétien
Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4922-6.
1993: Majambu Mbikay; Nabil G Seidah; M Chretien
From proopiomelanocortin to cancer. Possible role of convertases in neoplasia.
Annals of the New York Academy of Sciences 1993;680():13-9.
1993: Aristea S Galanopoulou; Geraldine Kent; S N Rabbani; Nabil G Seidah; Yogesh C Patel
Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2.
The Journal of biological chemistry 1993;268(8):6041-9.
1992: Nabil G Seidah; H Fournier; Guy Boileau; Suzanne Benjannet; N Rondeau; Michel Chrétien
The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC.
FEBS letters 1992;310(3):235-9.
1992: A Basak; X W Yuan; Nabil G Seidah; Michel Chrétien; C Lazure
Affinity purification of proteinases by a combination of immobilized peptidyl aldehyde and semicarbazone.
Journal of chromatography 1992;581(1):17-29.
1992: Nabil G Seidah; R Day; J Hamelin; A Gaspar; M W Collard; Michel Chrétien
Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1559-70.
1992: Suzanne Benjannet; Timothy L Reudelhuber; C Mercure; N Rondeau; Michel Chrétien; Nabil G Seidah
Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.
The Journal of biological chemistry 1992;267(16):11417-23.
1992: Nabil G Seidah; Robert Day; Suzanne Benjannet; N Rondeau; A Boudreault; Timothy L Reudelhuber; M K Schafer; S J Watson; Michel Chrétien
The prohormone and proprotein processing enzymes PC1 and PC2: structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation.
NIDA research monograph 1992;126():132-50.
1991: L Paquet; N Rondeau; Nabil G Seidah; Claude Lazure; Michel Chrétien; Majambu Mbikay
Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2.
FEBS letters 1991;294(1-2):23-6.
1991: Claude Lazure; Suzanne Benjannet; Nabil G Seidah; Michel Chrétien
Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts.
International journal of peptide and protein research 1991;38(4):392-400.
1991: Nabil G Seidah; M G Mattei; L Gaspar; Suzanne Benjannet; Majambu Mbikay; Michel Chrétien
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Genomics 1991;11(1):103-7.
1991: Suzanne Benjannet; N Rondeau; Robert Day; Michel Chrétien; Nabil G Seidah
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3564-8.
1991: N Sawyer; N Rondeau; Michel Chrétien; Nabil G Seidah
Expression and sorting of rat plasma kallikrein in POMC-producing AtT-20 cells.
DNA and cell biology 1991;10(4):259-69.
1991: G Beaubien; I Rosinski-Chupin; M G Mattei; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Gene structure and chromosomal localization of plasma kallikrein.
Biochemistry 1991;30(6):1628-35.
1991: L Paquet; Claude Lazure; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.
Biochemical and biophysical research communications 1991;174(1):156-62.
1991: Nabil G Seidah; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; L Gaspar; G Beaubien; M G Mattei; Claude Lazure; Majambu Mbikay; Michel Chrétien
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.
Molecular endocrinology (Baltimore, Md.) 1991;5(1):111-22.
1991: M Chretien; L Gasper; Suzanne Benjannet; Majambu Mbikay; Claude Lazure; Nabil G Seidah
The Jeremiah Metzger Lecture. From POMC to functional diversity of neural peptides: the key importance of convertases.
Transactions of the American Clinical and Climatological Association 1991;102():195-224.
1991: Nabil G Seidah; R Day; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; Michel Chrétien
Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases.
Enzyme 1991;45(5-6):271-84.
1990: Nabil G Seidah; L Gaspar; P Mion; Mieczyslaw Marcinkiewicz; Majambu Mbikay; Michel Chrétien
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
DNA and cell biology 1990;9(10):789.
1990: Nabil G Seidah; N Sawyer; Josée Hamelin; P Mion; G Beaubien; L Brachpapa; J Rochemont; Majambu Mbikay; Michel Chrétien
Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species.
DNA and cell biology 1990;9(10):737-48.
1990: Ajoy Basak; Y T Gong; J A Cromlish; J A Paquin; F Jean; Nabil G Seidah; Claude Lazure; Michel Chrétien
Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases.
International journal of peptide and protein research 1990;36(1):7-17.
1990: Nabil G Seidah; L Gaspar; P Mion; Mieczyslaw Marcinkiewicz; Majambu Mbikay; Michel Chrétien
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
DNA and cell biology 1990;9(6):415-24.
1990: C G Linard; Majambu Mbikay; Nabil G Seidah; M Chretien
Primary structure of mouse chromogranin B deduced from cDNA sequence.
Nucleic acids research 1990;18(5):1298.
1990: M G Mattei; Majambu Mbikay; B S Sylla; G Lenoir; J F Mattei; Nabil G Seidah; M Chretien
Assignment of the gene for neuroendocrine protein 7B2 (SGNE1 locus) to mouse chromosome region 2[E3-F3] and to human chromosome region 15q11-q15.
Genomics 1990;6(3):436-40.
1989: J Paquin; Suzanne Benjannet; N Sawyer; Claude Lazure; Michel Chrétien; Nabil G Seidah
Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay.
Biochimica et biophysica acta 1989;999(2):103-10.
1989: Puttaswamy Manjunath; Yves L Marcel; J Uma; Nabil G Seidah; Michel Chrétien; A Chapdelaine
Apolipoprotein A-I binds to a family of bovine seminal plasma proteins.
The Journal of biological chemistry 1989;264(28):16853-7.
1989: F Gilbert; J S Chan; Suzanne Benjannet; Nabil G Seidah; P Nadeau; André Duranceau; E Lafontaine; R Beaulieu; Michel Chrétien
Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(5):285-91.
1989: L Gaspar; F Gilbert; J S Chan; Nabil G Seidah; Michel Chrétien
Urinary levels of immunoreactive NH2-terminal of pro-opiomelanocortin in patients with malignant pulmonary disease.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(4):241-6.
1989: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Peptides related to the N-terminus of pro-opiomelanocortin in the human adrenal medulla.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(2):90-8.
1989: Xavier Bertagna; Nabil G Seidah; JF Massias; F Lenne; Jean Pierre Luton; F Girard; M Chretien
Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid beta-melanocyte stimulating hormone [h beta MSH(5-22)] in nonpituitary tissue.
Peptides 1989;10(1):83-7.
1989: Majambu Mbikay; S G Grant; F Sirois; H Tadros; J Skowronski; C Lazure; Nabil G Seidah; Douglas Hanahan; Michel Chrétien
cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice.
International journal of peptide and protein research 1989;33(1):39-45.
1988: C G Linard; Majambu Mbikay; Suzanne Benjannet; C Lazure; Nabil G Seidah; M Chrétien
Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli.
Gene 1988;73(2):479-87.
1988: Mieczyslaw Marcinkiewicz; R Fischer-Colbrie; Jean-Pierre Falgueyret; Suzanne Benjannet; Nabil G Seidah; Claude Lazure; H Winkler; Michel Chrétien
Two-dimensional immunoblotting analysis and immunocytochemical localization of the secretory polypeptide 7B2 in adrenal medulla.
Neuroscience letters 1988;95(1-3):81-7.
1988: K M Metters; J Rossier; J Paquin; Michel Chrétien; Nabil G Seidah
Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein.
The Journal of biological chemistry 1988;263(25):12543-53.
1988: Mieczyslaw Marcinkiewicz; Suzanne Benjannet; Jean-Pierre Falgueyret; Nabil G Seidah; W Schürch; M Verdy; M Cantin; Michel Chrétien
Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma.
Endocrinology 1988;123(2):866-73.
1988: Suzanne Benjannet; Mieczyslaw Marcinkiewicz; Jean-Pierre Falgueyret; D E Johnson; Nabil G Seidah; Michel Chrétien
Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors.
Endocrinology 1988;123(2):874-84.
1988: A Brar; Majambu Mbikay; F Sirois; S Fournier; Nabil G Seidah; Michel Chrétien
Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate.
Journal of andrology 1988;9(4):253-60.
1988: Nabil G Seidah; J Paquin; Josée Hamelin; Suzanne Benjannet; M Chretien
Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing.
Biochimie 1988;70(1):33-46.
1988: Majambu Mbikay; C G Linard; F Sirois; C Lazure; Nabil G Seidah; M Chretien
Tissue-specific expression of the prostatic secretory protein PSP94 in cynomolgus monkey (Macaca fascicularis.
Cellular and molecular biology 1988;34(4):387-98.
1987: Suzanne Benjannet; R Leduc; N Adrouche; Jean-Pierre Falgueyret; Mieczyslaw Marcinkiewicz; Nabil G Seidah; Majambu Mbikay; Claude Lazure; M Chretien
Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues.
FEBS letters 1987;224(1):142-8.
1987: Huy Ong; C Lazure; T T Nguyen; Normand McNicoll; Nabil G Seidah; M Chrétien; André De Léan
Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor.
Biochemical and biophysical research communications 1987;147(3):957-63.
1987: Jean-Pierre Falgueyret; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; M Cantin; Nabil G Seidah; Michel Chrétien
Immunocytochemical localization of a novel pituitary polypeptide "7B2" in the gastro-intestinal tract of the rat.
Cell and tissue research 1987;249(3):707-9.
1987: F Gilbert; W Walop; J S Chan; Suzanne Benjannet; Nabil G Seidah; W O Spitzer; Michel Chrétien
The role of the NH2-terminal portion of pro-opiomelanocortin as a biomarker for human lung cancer.
Clinical and investigative medicine. Médecine clinique et experimentale 1987;10(5):372-6.
1987: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid.
The Journal of clinical endocrinology and metabolism 1987;65(1):198-202.
1987: Nabil G Seidah; Geoffrey N Hendy; Josée Hamelin; J Paquin; Claude Lazure; K M Metters; J Rossier; Michel Chrétien
Chromogranin A can act as a reversible processing enzyme inhibitor. Evidence from the inhibition of the IRCM-serine protease 1 cleavage of pro-enkephalin and ACTH at pairs of basic amino acids.
FEBS letters 1987;211(2):144-50.
1987: J Michael Walker; A Ghessari; B A Peters; Stanley J Watson Jr; Nabil G Seidah; M Chretien; Huda Akil
Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products.
Pain and headache 1987;9():160-77.
1985: W H Berrettini; J I Nurnberger; J S Chan; G P Chrousos; L Gaspar; P W Gold; Nabil G Seidah; S Simmons-Alling; L R Goldin; Michel Chrétien
Pro-opiomelanocortin-related peptides in cerebrospinal fluid: a study of manic-depressive disorder.
Psychiatry research 1985;16(4):287-302.
1985: Mieczyslaw Marcinkiewicz; Suzanne Benjannet; R A Sikstrom; M Cantin; Nabil G Seidah; M Chretien
Immunoreactivity of vasopressin and a novel pituitary protein '7B2' in Long-Evans and Brattleboro rat hypothalamus and hypophysis.
Neuroscience letters 1985;60(1):7-12.
1985: Suzanne Benjannet; R Leduc; Claude Lazure; Nabil G Seidah; Mieczyslaw Marcinkiewicz; Michel Chrétien
GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.
Biochemical and biophysical research communications 1985;126(1):602-9.
1985: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Characterization of peptides derived from pro-opiomelanocortin in the biological fluids of a patient with Nelson's syndrome.
Clinical and investigative medicine. Médecine clinique et experimentale 1985;8(2):167-75.
1984: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney.
The Journal of clinical endocrinology and metabolism 1984;59(4):614-21.
1984: J S Chan; L Gaspar; H Iguchi; Nabil G Seidah; N Ling; Michel Chrétien
Synergistical effects of ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on the release of pro-opiomelanocortin (POMC) related peptides by pituitary adenoma of a patient with Nelson's syndrome in vitro.
Clinical and investigative medicine. Médecine clinique et experimentale 1984;7(4):205-8.
1983: Nabil G Seidah; K L Hsi; G De Serres; J Rochemont; Josée Hamelin; T Antakly; M Cantin; Michel Chrétien
Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus.
Archives of biochemistry and biophysics 1983;225(2):525-34.
1983: Nabil G Seidah; D Pélaprat; J Rochemont; P Lambelin; M Dennis; J S Chan; Josée Hamelin; Claude Lazure; Michel Chrétien
Enzymatic maturation of pro-opiomelanocortin by anterior pituitary granules. Methodological approach leading to definite characterization of cleavage sites by means of high-performance liquid chromatography and microsequencing.
Journal of chromatography 1983;266():213-24.
1983: Guy Boileau; F Gossard; Nabil G Seidah; Michel Chrétien
Cell-free synthesis of porcine proopiomelanocortin: two distinct primary translation products.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1983;61(6):333-9.
1982: K L Hsi; Nabil G Seidah; G De Serres; Michel Chrétien
Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.
FEBS letters 1982;147(2):261-6.
1982: Guy Boileau; N Larivière; K L Hsi; Nabil G Seidah; Michel Chrétien
Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide.
Biochemistry 1982;21(21):5341-6.
1982: Nabil G Seidah; N Larivière; Guy Boileau; F Gossard; K L Hsi; C L Lu; Michel Chrétien
Gene expression of peptides: the pro-opiomelanocortin model.
Advances in biochemical psychopharmacology 1982;33():19-26.
1981: K L Hsi; Nabil G Seidah; C L Lu; Michel Chrétien
Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands.
Biochemical and biophysical research communications 1981;103(4):1329-35.
1981: Nabil G Seidah; J Rochemont; Josée Hamelin; Suzanne Benjannet; Michel Chrétien
The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation.
Biochemical and biophysical research communications 1981;102(2):710-6.
1981: Nabil G Seidah; J Rochemont; Josée Hamelin; M Lis; Michel Chrétien
Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity.
The Journal of biological chemistry 1981;256(15):7977-84.
1980: N Larivière; Nabil G Seidah; G De Serres; J Rochemont; Michel Chrétien
Two glycosylation sites on the N-terminal segment of porcine pars distalis pro-opiomelanocortin.
FEBS letters 1980;122(2):279-82.
1980: Philippe Crine; Nabil G Seidah; R Routhier; F Gossard; Michel Chrétien
Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides.
European journal of biochemistry / FEBS 1980;110(2):387-96.
1980: Michel Chrétien; F Gossard; Philippe Crine; C Gianoulakis; Nabil G Seidah
New perspectives in neuropeptides. Biosynthesis from large precursors. The pro-opio-melanocortin model in the pars intermedia.
Acta psychiatrica Belgica 1980;80(5):699-713.
1980: Nabil G Seidah; Suzanne Benjannet; R Routhier; G De Serres; J Rochemont; M Lis; Michel Chrétien
Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence.
Biochemical and biophysical research communications 1980;95(4):1417-24.
1980: C Gianoulakis; Nabil G Seidah; R Routhier; Michel Chrétien
Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis. Further characterization.
International journal of peptide and protein research 1980;16(2):97-105.
1980: S Benjannet; Nabil G Seidah; R Routhier; Michel Chrétien
A novel human pituitary peptide containing the gamma-MSH sequence.
Nature 1980;285(5764):415-6.
1980: Nabil G Seidah; R Routhier; S Benjannet; N Larivière; F Gossard; Michel Chrétien
Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments.
Journal of chromatography 1980;193(2):291-9.
1980: F Gossard; Nabil G Seidah; Philippe Crine; R Routhier; Michel Chrétien
Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia.
Biochemical and biophysical research communications 1980;92(3):1042-51.
1980: Michel Chrétien; F Gossard; Philippe Crine; C Gianoulakis; Nabil G Seidah
Structure and maturation process of pro-opiomelanocortin: a model for other neuropeptides.
Advances in biochemical psychopharmacology 1980;22():153-66.
1980: Nabil G Seidah; F Gossard; Philippe Crine; C Gianoulakis; R Routhier; Michel Chrétien
Chemical characterization of rat alpha MSH/beta-endorphin precursor from pars intermedia.
Annals of the New York Academy of Sciences 1980;343():443-6.