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Christof Seidl

Research Profile

Chemicals & Drugs

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Tumor Cell Line

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Physiology

Gene Expression Regulation, Neoplastic

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Publications

TOP 3
Christof Seidl; Markus Essler
Radioimmunotherapy for peritoneal cancers.
Benedikt Feuerecker; Sabine Pirsig; Christof Seidl; Michaela Aichler; Gernot Bruchelt; Annette Feuchtinger; Reingard Senekowitsch-Schmidtke
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo.
Mario Vallon; Axel K Walch; Michaela Aichler; Anja Baumgart; Birgit Blechert; Frank Bruchertseifer; Annette Feuchtinger; Florian C Gaertner; Klaus-Peter Gilbertz; Zhoulei Li; Alfred Morgenstern; Christof Seidl; Reingard Senekowitsch-Schmidtke; Markus Essler
Enhanced efficacy of combined 213Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest.

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All Publications

2013: Christof Seidl; Markus Essler
Radioimmunotherapy for peritoneal cancers.
Immunotherapy 2013;5(4):395-405.
2012: Benedikt Feuerecker; Sabine Pirsig; Christof Seidl; Michaela Aichler; Gernot Bruchelt; Annette Feuchtinger; Reingard Senekowitsch-Schmidtke
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo.
Cancer biology & therapy 2012;13(14):1425-35.
2012: Mario Vallon; Axel K Walch; Michaela Aichler; Anja Baumgart; Birgit Blechert; Frank Bruchertseifer; Annette Feuchtinger; Florian C Gaertner; Klaus-Peter Gilbertz; Zhoulei Li; Alfred Morgenstern; Christof Seidl; Reingard Senekowitsch-Schmidtke; Markus Essler
Enhanced efficacy of combined 213Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest.
European journal of nuclear medicine and molecular imaging 2012;39(12):1886-97.
2012: Christian Rauch; Martin Schlapschy; Christof Seidl; Frank Bruchertseifer; Alfred Morgenstern; Arne Skerra; Reingard Senekowitsch-Schmidtke
High molecular mass radioimmunoconjugates are promising for intraperitoneal α-emitter immunotherapy due to prolonged retention in the peritoneum.
Nuclear medicine and biology 2012;39(5):617-27.
2012: Markus Essler; Florian C Gärtner; Alfred Morgenstern; Frauke Neff; Birgit Blechert; Frank Bruchertseifer; Reingard Senekowitsch-Schmidtke; Christof Seidl
Therapeutic efficacy and toxicity of 225Ac-labelled vs. 213Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis.
European journal of nuclear medicine and molecular imaging 2012;39(4):602-12.
2011: Christof Seidl; Christine Zöckler; Roswitha Beck; Leticia Quintanilla-Martinez; Frank Bruchertseifer; Reingard Senekowitsch-Schmidtke
177Lu-immunotherapy of experimental peritoneal carcinomatosis shows comparable effectiveness to 213Bi-immunotherapy, but causes toxicity not observed with 213Bi.
European journal of nuclear medicine and molecular imaging 2011;38(2):312-22.
2010: Christof Seidl; Matthias Port; Christos Apostolidis; Frank Bruchertseifer; Markus Schwaiger; Reingard Senekowitsch-Schmidtke; Michael Abend
Differential gene expression triggered by highly cytotoxic alpha-emitter-immunoconjugates in gastric cancer cells.
Investigational new drugs 2010;28(1):49-60.
2009: Birgit Pfost; Christof Seidl; Michael Autenrieth; Dieter Saur; Frank Bruchertseifer; Alfred Morgenstern; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(10):1700-8.
2009: Sebastian A Müller; Korbinian Holzapfel; Christof Seidl; Uwe Treiber; Bernd J Krause; Reingard Senekowitsch-Schmidtke
Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment.
European journal of nuclear medicine and molecular imaging 2009;36(9):1434-42.
2009: Enken Drecoll; Florian C Gaertner; Matthias Miederer; Birgit Blechert; Mario Vallon; Jan M Müller; Andrea Alke; Christof Seidl; Frank Bruchertseifer; Alfred Morgenstern; Reingard Senekowitsch-Schmidtke; Markus Essler
Treatment of peritoneal carcinomatosis by targeted delivery of the radio-labeled tumor homing peptide bi-DTPA-[F3]2 into the nucleus of tumor cells.
PloS one 2009;4(5):e5715.
2008: Korbinian Holzapfel; Sebastian A Müller; Christof Seidl; Anca L Grosu; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Effects of irradiation on the [Methyl-3H]choline uptake in the human prostate cancer cell lines LNCaP and PC3.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2008;184(6):319-24.
2008: Sebastian Knör; Sumito Sato; Timo Huber; Alfred Morgenstern; Frank Bruchertseifer; Manfred Schmitt; Horst Kessler; Reingard Senekowitsch-Schmidtke; Viktor Magdolen; Christof Seidl
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer.
European journal of nuclear medicine and molecular imaging 2008;35(1):53-64.
2007: Christof Seidl; Matthias Port; Klaus-Peter Gilbertz; Alfred Morgenstern; Frank Bruchertseifer; Markus Schwaiger; Barbara Röper; Reingard Senekowitsch-Schmidtke; Michael Abend
213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe.
Molecular cancer therapeutics 2007;6(8):2346-59.
2007: Roswitha Beck; Christof Seidl; Birgit Pfost; Alfred Morgenstern; Frank Bruchertseifer; Hannsjörg Baum; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
213Bi-radioimmunotherapy defeats early-stage disseminated gastric cancer in nude mice.
Cancer science 2007;98(8):1215-22.
2007: H Matthias Buchhorn; Christof Seidl; Roswitha Beck; Dieter Saur; Christos Apostolidis; Alfred Morgenstern; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Non-invasive visualisation of the development of peritoneal carcinomatosis and tumour regression after 213Bi-radioimmunotherapy using bioluminescence imaging.
European journal of nuclear medicine and molecular imaging 2007;34(6):841-9.
2006: Barbara Stöber; Ursula Tanase; Michael Herz; Christof Seidl; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Differentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells.
European journal of nuclear medicine and molecular imaging 2006;33(8):932-9.
2006: U Rössler; Sabine Hornhardt; Christof Seidl; E Müller-Laue; Linda Walsh; Werner Panzer; Ernst Schmid; Reingard Senekowitsch-Schmidtke; Maria Gomolka
The sensitivity of the alkaline comet assay in detecting DNA lesions induced by X rays, gamma rays and alpha particles.
Radiation protection dosimetry 2006;122(1-4):154-9.
2005: Stefanie Bloechl; Roswitha Beck; Christof Seidl; Alfred Morgenstern; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Fractionated locoregional low-dose radioimmunotherapy improves survival in a mouse model of diffuse-type gastric cancer using a 213Bi-conjugated monoclonal antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 2):7070s-7074s.
2005: Christof Seidl; Hedwig Schröck; Sabine Seidenschwang; Roswitha Beck; Ernst Schmid; Michael Abend; Karl-Friedrich Becker; Christos Apostolidis; Tuomo K Nikula; Elisabeth Kremmer; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death.
European journal of nuclear medicine and molecular imaging 2005;32(3):274-85.
2003: Roswitha Huber; Christof Seidl; Ernst Schmid; Sabine Seidenschwang; Karl-Friedrich Becker; Christoph Schuhmacher; Christos Apostolidis; Tuomo K Nikula; Elisabeth Kremmer; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Locoregional alpha-radioimmunotherapy of intraperitoneal tumor cell dissemination using a tumor-specific monoclonal antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 2):3922S-8S.
2003: Miederer Matthias; Christof Seidl; Gerd-Jürgen Beyer; David E Charlton; Sanja Vranjes-Duric; Jozef J Comor; Roswitha Huber; Tuomo K Nikula; Christos Apostolidis; Christoph Schuhmacher; Karl-Friedrich Becker; Reingard Senekowitsch-Schmidtke
Comparison of the radiotoxicity of two alpha-particle-emitting immunoconjugates, terbium-149 and bismuth-213, directed against a tumor-specific, exon 9 deleted (d9) E-cadherin adhesion protein.
Radiation research 2003;159(5):612-20.
2001: Reingard Senekowitsch-Schmidtke; Christoph Schuhmacher; Karl-Friedrich Becker; Tuomo K Nikula; Christof Seidl; I Becker; Miederer Matthias; Christos Apostolidis; C Adam; Roswitha Huber; Elisabeth Kremmer; K Fischer; Markus Schwaiger
Highly specific tumor binding of a 213Bi-labeled monoclonal antibody against mutant E-cadherin suggests its usefulness for locoregional alpha-radioimmunotherapy of diffuse-type gastric cancer.
Cancer research 2001;61(7):2804-8.