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Frederic Seidler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Prenatal Exposure Delayed Effects

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Co-Publications
Name
258
Slotkin, Theodore
33
McCook, EC
27
Tate, Charlotte
21
Cousins, Mandy
19
Levin, Edward
17
Ryde, Ian
17
Qiao, Dan
9
Auman, Todd
9
Aldridge, Justin
8
Bartolome, Jorge
8
Mackillop, Emiko
7
Meyer, Armando
7
Abreu-Villaça, Yael
6
Kreider, Marisa
6
Trauth, JA

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Publications

TOP 3
Yanai Joseph; Pinkas Adi; Seidler Frederic J; Ryde Ian T; Van der Zee Eddy A; Slotkin Theodore A
Neurobehavioral teratogenicity of sarin in an avian model.
Slotkin Theodore A; Wrench Nicola; Ryde Ian T; Lassiter T Leon; Levin Edward D; Seidler Frederic J
Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.
Slotkin Theodore A; Seidler Frederic J
Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.

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All Publications

2009: Yanai Joseph; Pinkas Adi; Seidler Frederic J; Ryde Ian T; Van der Zee Eddy A; Slotkin Theodore A
Neurobehavioral teratogenicity of sarin in an avian model.
Neurotoxicology and teratology 2009;31(6):406-12.
2009: Slotkin Theodore A; Wrench Nicola; Ryde Ian T; Lassiter T Leon; Levin Edward D; Seidler Frederic J
Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.
Neurotoxicology and teratology 2009;31(6):390-9.
2009: Slotkin Theodore A; Seidler Frederic J
Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.
Brain research bulletin 2009;80(1-2):17-21.
2009: Slotkin Theodore A; Lassiter T Leon; Ryde Ian T; Wrench Nicola; Levin Edward D; Seidler Frederic J
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.
Environmental health perspectives 2009;117(6):916-22.
2009: Slotkin Theodore A; Ryde Ian T; Wrench Nicola; Card Jennifer A; Seidler Frederic J
Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions.
Neurotoxicology and teratology 2009;31(3):183-6.
2009: Slotkin Theodore A; Seidler Frederic J
Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.
Environmental health perspectives 2009;117(4):587-96.
2009: Slotkin Theodore A; Seidler Frederic J
Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
Brain research 2009;1263():23-32.
2009: Slotkin Theodore A; Seidler Frederic J; Wu Changlong; MacKillop Emiko A; Linden Karl G
Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.
Environmental health perspectives 2009;117(3):338-43.
2009: Lassiter T Leon; MacKillop Emiko A; Ryde Ian T; Seidler Frederic J; Slotkin Theodore A
Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.
Brain research bulletin 2009;78(6):313-22.
2009: Slotkin Theodore A; Seidler Frederic J
Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood.
Developmental neuroscience 2009;31(1-2):58-70.
2008: Slotkin Theodore A; Seidler Frederic J
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.
Toxicology and applied pharmacology 2008;233(2):211-9.
2008: Timofeeva Olga A; Sanders David; Seemann Kristen; Yang Liwei; Hermanson Daniel; Regenbogen Sam; Agoos Samantha; Kallepalli Anita; Rastogi Anit; Braddy David; Wells Corinne; Perraut Charles; Seidler Frederic J; Slotkin Theodore A; Levin Edward D
Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.
Brain research bulletin 2008;77(6):404-11.
2008: Lassiter T Leon; Ryde Ian T; Mackillop Emiko A; Brown Kathleen K; Levin Edward D; Seidler Frederic J; Slotkin Theodore A
Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood.
Environmental health perspectives 2008;116(11):1456-62.
2008: Buznikov Gennady A; Nikitina Lyudmila A; Seidler Frederic J; Slotkin Theodore A; Bezuglov Vladimir V; Milosevic Ivan; Lazarevic Lidija; Rogac Ljubica; Ruzdijic Sabera; Rakic Ljubisa M
Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.
Neurotoxicology and teratology 2008;30(6):503-9.
2008: Slotkin Theodore A; Bodwell Bethany E; Ryde Ian T; Levin Edward D; Seidler Frederic J
Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood.
Environmental health perspectives 2008;116(10):1308-14.
2008: Slotkin Theodore A; Seidler Frederic J; Ryde Ian T; Yanai Joseph
Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.
Neurotoxicology and teratology 2008;30(5):433-9.
2008: Slotkin Theodore A; Seidler Frederic J; Wood Carmen R; Lau Christopher
Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants.
Brain research bulletin 2008;76(5):531-5.
2008: Slotkin Theodore A; Ryde Ian T; Mackillop Emiko A; Bodwell Bethany E; Seidler Frederic J
Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects.
Brain research bulletin 2008;76(5):522-30.
2008: Slotkin Theodore A; Seidler Frederic J; Fumagalli Fabio
Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.
Brain research bulletin 2008;76(4):424-38.
2008: Slotkin Theodore A; MacKillop Emiko A; Melnick Ronald L; Thayer Kristina A; Seidler Frederic J
Developmental neurotoxicity of perfluorinated chemicals modeled in vitro.
Environmental health perspectives 2008;116(6):716-22.
2008: Slotkin Theodore A; Bodwell Bethany E; Ryde Ian T; Seidler Frederic J
Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood.
Brain research bulletin 2008;76(1-2):152-65.
2008: Slotkin Theodore A; Ryde Ian T; Levin Edward D; Seidler Frederic J
Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.
Brain research bulletin 2008;75(5):640-7.
2008: Slotkin Theodore A; Bodwell Bethany E; Levin Edward D; Seidler Frederic J
Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.
Environmental health perspectives 2008;116(3):340-8.
2008: Roegge Cindy S; Timofeeva Olga A; Seidler Frederic J; Slotkin Theodore A; Levin Edward D
Developmental diazinon neurotoxicity in rats: later effects on emotional response.
Brain research bulletin 2008;75(1):166-72.
2008: Timofeeva Olga A; Roegge Cindy S; Seidler Frederic J; Slotkin Theodore A; Levin Edward D
Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.
Neurotoxicology and teratology 2008;30(1):38-45.
2008: Yanai Joseph; Dotan Sharon; Goz Roman; Pinkas Adi; Seidler Frederic J; Slotkin Theodore A; Zimmerman Frederic
Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development.
Journal of toxicology and environmental health. Part A 2008;71(2):131-3.
2007: Slotkin Theodore A; MacKillop Emiko A; Ryde Ian T; Seidler Frederic J
Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
Environmental health perspectives 2007;115(9):1306-13.
2007: Slotkin Theodore A; Ryde Ian T; Seidler Frederic J
Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions.
Brain research bulletin 2007;74(1-3):91-103.
2007: Slotkin Theodore A; Seidler Frederic J
Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.
Brain research bulletin 2007;73(4-6):301-9.
2007: Slotkin Theodore A; Ryde Ian T; Tate Charlotte A; Seidler Frederic J
Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood.
Brain research bulletin 2007;73(4-6):259-72.
2007: Levin Edward D; Lawrence Susan Slade; Petro Ann; Horton Kofi; Rezvani Amir H; Seidler Frederic J; Slotkin Theodore A
Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.
Neurotoxicology and teratology 2007;29(4):458-65.
2007: Slotkin Theodore A; Seidler Frederic J; Fumagalli Fabio
Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.
Environmental health perspectives 2007;115(6):909-16.
2007: Slotkin Theodore A; Seidler Frederic J
Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems.
Brain research bulletin 2007;72(4-6):232-74.
2007: Slotkin Theodore A; MacKillop Emiko A; Rudder Charles L; Ryde Ian T; Tate Charlotte A; Seidler Frederic J
Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(5):1082-97.
2007: Slotkin Theodore A; Seidler Frederic J
Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects.
Reproductive toxicology (Elmsford, N.Y.) 2007;23(3):421-7.
2007: Slotkin Theodore A; MacKillop Emiko A; Ryde Ian T; Tate Charlotte A; Seidler Frederic J
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.
Environmental health perspectives 2007;115(1):93-101.
2007: Jameson Ruth R; Seidler Frederic J; Slotkin Theodore A
Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.
Environmental health perspectives 2007;115(1):65-70.
2007: Slotkin Theodore A; Seidler Frederic J
A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration.
Neurotoxicology and teratology 2007;29(1):10-6.
2006: Levin Edward D; Lawrence Susan; Petro Ann; Horton Kofi; Seidler Frederic J; Slotkin Theodore A
Increased nicotine self-administration following prenatal exposure in female rats.
Pharmacology, biochemistry, and behavior 2006;85(3):669-74.
2006: Slotkin Theodore A; Tate Charlotte A; Cousins Mandy M; Seidler Frederic J
Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(11):2462-75.
2006: Slotkin Theodore A; Tate Charlotte A; Ryde Ian T; Levin Edward D; Seidler Frederic J
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.
Environmental health perspectives 2006;114(10):1542-6.
2006: Slotkin Theodore A; Pinkerton Kent E; Tate Charlotte A; Seidler Frederic J
Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke.
Brain research 2006;1111(1):30-5.
2006: Jameson Ruth R; Seidler Frederic J; Qiao Dan; Slotkin Theodore A
Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(8):1647-58.
2006: Slotkin Theodore A; Levin Edward D; Seidler Frederic J
Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity.
Environmental health perspectives 2006;114(5):746-51.
2006: Jameson Ruth R; Seidler Frederic J; Qiao Dan; Slotkin Theodore A
Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.
Environmental health perspectives 2006;114(5):667-72.
2006: Slotkin Theodore A; Kreider Marisa L; Tate Charlotte A; Seidler Frederic J
Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(5):904-11.
2006: Slotkin Theodore A; Seidler Frederic J
Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat.
Brain research 2006;1077(1):54-8.
2006: Slotkin Theodore A; Pinkerton Kent E; Seidler Frederic J
Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation.
Environmental health perspectives 2006;114(1):34-9.
2006: Slotkin Theodore A; Seidler Frederic J
Cholinergic receptor subtypes in the olfactory bulbectomy model of depression.
Brain research bulletin 2006;68(5):341-5.
2006: Kreider Marisa L; Tate Charlotte A; Cousins Mandy M; Oliver Colleen A; Seidler Frederic J; Slotkin Theodore A
Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(1):12-35.
2005: Slotkin Theodore A; Tate Charlotte A; Cousins Mandy M; Seidler Frederic J
Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.
Brain research. Developmental brain research 2005;160(2):219-30.
2005: Slotkin Theodore A; Brown Kathleen K; Seidler Frederic J
Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood.
Environmental health perspectives 2005;113(10):1291-4.
2005: Kreider Marisa L; Aldridge Justin E; Cousins Mandy M; Oliver Colleen A; Seidler Frederic J; Slotkin Theodore A
Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(10):1841-55.
2005: Kreider Marisa L; Levin Edward D; Seidler Frederic J; Slotkin Theodore A
Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(9):1617-23.
2005: Aldridge Justin E; Meyer Armando; Seidler Frederic J; Slotkin Theodore A
Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.
Environmental health perspectives 2005;113(8):1027-31.
2005: Slotkin Theodore A; Seidler Frederic J
The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent.
Brain research. Developmental brain research 2005;158(1-2):115-9.
2005: Qiao Dan; Seidler Frederic J; Slotkin Theodore A
Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.
Toxicology and applied pharmacology 2005;206(1):17-26.
2005: Slotkin Theodore A; Oliver Colleen A; Seidler Frederic J
Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
Brain research. Developmental brain research 2005;157(2):172-80.
2005: Aldridge Justin E; Levin Edward D; Seidler Frederic J; Slotkin Theodore A
Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.
Environmental health perspectives 2005;113(5):527-31.
2005: Roy Tara Sankar; Sharma Vikram; Seidler Frederic J; Slotkin Theodore A
Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats.
Brain research. Developmental brain research 2005;155(1):71-80.
2005: Meyer Armando; Seidler Frederic J; Aldridge Justin E; Slotkin Theodore A
Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.
Toxicology and applied pharmacology 2005;203(2):154-66.
2005: Aldridge Justin E; Meyer Armando; Seidler Frederic J; Slotkin Theodore A
Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions.
Toxicology and applied pharmacology 2005;203(2):132-44.
2005: Abreu-Villaça Yael; Seidler Frederic J; Qiao Dan; Slotkin Theodore A
Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.
Brain research. Developmental brain research 2005;154(2):239-46.
2005: Beer Avital; Slotkin Theodore A; Seidler Frederic J; Aldridge Justin E; Yanai Joseph
Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):156-65.
2005: Slotkin Theodore A; Cousins Mandy M; Tate Charlotte A; Seidler Frederic J
Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):52-7.
2005: Slotkin Theodore A; Seidler Frederic J; Qiao Dan; Aldridge Justin E; Tate Charlotte A; Cousins Mandy M; Proskocil Becky J; Sekhon Harmanjatinder S; Clark Jennifer A; Lupo Stacie L; Spindel Eliot R
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):129-44.
2004: Slotkin Theodore A; Cousins Mandy M; Seidler Frederic J
Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors.
Brain research 2004;1030(1):159-63.
2004: Slotkin Theodore A; Southard Matthew C; Adam Stacey J; Cousins Mandy M; Seidler Frederic J
Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.
Brain research bulletin 2004;64(3):227-35.
2004: Kreider Marisa L; Seidler Frederic J; Cousins Mandy M; Tate Charlotte A; Slotkin Theodore A
Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain.
Brain research. Developmental brain research 2004;152(2):233-9.
2004: Abreu-Villaça Yael; Seidler Frederic J; Slotkin Theodore A
Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(8):1440-50.
2004: Abreu-Villaça Yael; Seidler Frederic J; Tate Charlotte A; Cousins Mandy M; Slotkin Theodore A
Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(5):879-90.
2004: Meyer Armando; Seidler Frederic J; Aldridge Justin E; Tate Charlotte A; Cousins Mandy M; Slotkin Theodore A
Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.
Environmental health perspectives 2004;112(3):295-301.
2004: Rhodes Melissa C; Seidler Frederic J; Qiao Dan; Tate Charlotte A; Cousins Mandy M; Slotkin Theodore A
Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats.
Toxicology and applied pharmacology 2004;195(2):203-17.
2004: Roy Tara Sankar; Seidler Frederic J; Slotkin Theodore A
Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia.
Brain research. Developmental brain research 2004;148(2):197-206.
2004: Meyer Armando; Seidler Frederic J; Slotkin Theodore A
Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.
Environmental health perspectives 2004;112(2):170-8.
2004: Aldridge Justin E; Seidler Frederic J; Slotkin Theodore A
Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.
Environmental health perspectives 2004;112(2):148-55.
2004: Rhodes Melissa C; Seidler Frederic J; Abdel-Rahman Ali; Tate Charlotte A; Nyska Abraham; Rincavage Heather L; Slotkin Theodore A
Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex.
The Journal of pharmacology and experimental therapeutics 2004;308(2):529-37.
2004: Icenogle Laura M; Christopher N Channelle; Blackwelder W Paul; Caldwell D Patrick; Qiao Dan; Seidler Frederic J; Slotkin Theodore A; Levin Edward D
Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.
Neurotoxicology and teratology 2004;26(1):95-101.
2004: Qiao Dan; Seidler Frederic J; Abreu-Villaça Yael; Tate Charlotte A; Cousins Mandy M; Slotkin Theodore A
Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.
Brain research. Developmental brain research 2004;148(1):43-52.
2004: Kreider Marisa L; Seidler Frederic J; Slotkin Theodore A
Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline.
Brain research bulletin 2004;62(4):305-14.
2003: Rhodes Melissa C; Nyska Abraham; Seidler Frederic J; Slotkin Theodore A
Does terbutaline damage the developing heart?
Birth defects research. Part B, Developmental and reproductive toxicology 2003;68(6):449-55.
2003: Qiao Dan; Seidler Frederic J; Violin Jonathan D; Slotkin Theodore A
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
Brain research. Developmental brain research 2003;147(1-2):183-90.
2003: Xu Zengjun; Seidler Frederic J; Tate Charlotte A; Garcia Stephanie J; Slikker William; Slotkin Theodore A
Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2003;5(6):955-60.
2003: Navarro Hernán A; Basta Patricia V; Seidler Frederic J; Slotkin Theodore A
Short-term adolescent nicotine exposure in rats elicits immediate and delayed deficits in T-lymphocyte function: critical periods, patterns of exposure, dose thresholds.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2003;5(6):859-68.
2003: Meyer Armando; Seidler Frederic J; Cousins Mandy M; Slotkin Theodore A
Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
Environmental health perspectives 2003;111(16):1871-6.
2003: Aldridge Justin E; Seidler Frederic J; Meyer Armando; Thillai Indira; Slotkin Theodore A
Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.
Environmental health perspectives 2003;111(14):1736-43.
2003: Qiao Dan; Nikitina Lyudmila A; Buznikov Gennady A; Lauder Jean M; Seidler Frederic J; Slotkin Theodore A
The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity.
Environmental health perspectives 2003;111(14):1730-5.
2003: Abreu-Villaça Yael; Seidler Frederic J; Qiao Dan; Tate Charlotte A; Cousins Mandy M; Thillai Indira; Slotkin Theodore A
Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1935-49.
2003: Abreu-Villaça Yael; Seidler Frederic J; Slotkin Theodore A
Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal.
Brain research 2003;988(1-2):164-72.
2003: Slotkin Theodore A; Seidler Frederic J; Yanai Joseph
Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity.
Brain research 2003;984(1-2):189-97.
2003: Slotkin Theodore A; Freibaum Brian D; Tate Charlotte A; Thillai Indira; Ferguson Sherry A; Cada Amy M; Seidler Frederic J
Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
Brain research 2003;981(1-2):118-25.
2003: Abreu-Villaça Yael; Seidler Frederic J; Tate Charlotte A; Slotkin Theodore A
Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations.
Brain research 2003;979(1-2):114-28.
2003: Slotkin Theodore A; Auman J Todd; Seidler Frederic J
Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs.
The Journal of pharmacology and experimental therapeutics 2003;306(1):1-7.
2003: Qiao Dan; Seidler Frederic J; Tate Charlotte A; Cousins Mandy M; Slotkin Theodore A
Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.
Environmental health perspectives 2003;111(4):536-44.
2003: Garcia Stephanie J; Seidler Frederic J; Slotkin Theodore A
Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities.
Environmental health perspectives 2003;111(3):297-303.
2003: Garofolo Melissa C; Seidler Frederic J; Cousins Mandy M; Tate Charlotte A; Qiao Dan; Slotkin Theodore A
Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver.
Brain research bulletin 2003;59(4):319-29.
2003: Dam Kristina; Seidler Frederic J; Slotkin Theodore A
Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics.
Brain research bulletin 2003;59(4):261-5.
2002: Levin Edward D; Addy Nii; Baruah Avanti; Elias Alana; Christopher N Channelle; Seidler Frederic J; Slotkin Theodore A
Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.
Neurotoxicology and teratology 2002;24(6):733-41.
2002: Qiao Dan; Seidler Frederic J; Padilla Stephanie; Slotkin Theodore A
Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?
Environmental health perspectives 2002;110(11):1097-103.
2002: Auman J T; Seidler F J; Slotkin T A
Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(5):R1236-44.
2002: Xu Z; Seidler F J; Cousins M M; Slikker W; Slotkin T A
Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase.
Brain research 2002;951(2):280-92.
2002: Auman J T; Seidler F J; Tate C A; Slotkin T A
Are developing beta-adrenoceptors able to desensitize? Acute and chronic effects of beta-agonists in neonatal heart and liver.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(1):R205-17.
2002: Garofolo M C; Seidler F J; Auman J T; Slotkin T A
beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(5):R1356-63.
2002: Slotkin T A; Pinkerton K E; Auman J T; Qiao D; Seidler F J
Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.
Brain research. Developmental brain research 2002;133(2):175-9.
2002: Slotkin T A; Tate C A; Cousins M M; Seidler F J
Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure.
Brain research. Developmental brain research 2002;133(2):163-73.
2002: Garcia Stephanie J; Seidler Frederic J; Qiao Dan; Slotkin Theodore A
Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.
Brain research. Developmental brain research 2002;133(2):151-61.
2002: Roy Tara Sankar; Seidler Frederic J; Slotkin Theodore A
Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex.
The Journal of pharmacology and experimental therapeutics 2002;300(1):124-33.
2001: Slotkin T A; Seidler F J; Yanai J
Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism.
Brain research. Developmental brain research 2001;132(1):69-79.
2001: Auman J T; Seidler F J; Tate C A; Slotkin T A
Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R1895-901.
2001: Slotkin T A; Tate C A; Cousins M M; Seidler F J
Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline.
Brain research. Developmental brain research 2001;131(1-2):113-25.
2001: Navarro H A; Basta P V; Seidler F J; Slotkin T A
Adolescent nicotine: deficits in immune function.
Brain research. Developmental brain research 2001;130(2):253-6.
2001: Navarro H A; Basta P V; Seidler F J; Slotkin T A
Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?
Brain research. Developmental brain research 2001;130(2):249-52.
2001: Auman J T; Seidler F J; Slotkin T A
Regulation of fetal cardiac and hepatic beta-adrenoceptors and adenylyl cyclase signaling: terbutaline effects.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(4):R1079-89.
2001: Qiao D; Seidler F J; Slotkin T A
Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.
Environmental health perspectives 2001;109(9):909-13.
2001: Xu Z; Seidler F J; Ali S F; Slikker W; Slotkin T A
Fetal and adolescent nicotine administration: effects on CNS serotonergic systems.
Brain research 2001;914(1-2):166-78.
2001: Levin E D; Addy N; Nakajima A; Christopher N C; Seidler F J; Slotkin T A
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.
Brain research. Developmental brain research 2001;130(1):83-9.
2001: Raines K W; Seidler F J; Slotkin T A
Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.
Brain research. Developmental brain research 2001;130(1):65-72.
2001: Slotkin T A; Cousins M M; Tate C A; Seidler F J
Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure.
Brain research 2001;902(2):229-43.
2001: Slotkin T A; Pinkerton K E; Garofolo M C; Auman J T; McCook E C; Seidler F J
Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats.
Brain research 2001;898(1):73-81.
2001: Crumpton T L; Seidler F J; Slotkin T A
Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.
Breast cancer research and treatment 2001;66(2):143-6.
2001: Trauth J A; Seidler F J; Ali S F; Slotkin T A
Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function.
Brain research 2001;892(2):269-80.
2001: Garcia S J; Seidler F J; Crumpton T L; Slotkin T A
Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
Brain research 2001;891(1-2):54-68.
2000: Slotkin T A; Seidler F J
Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells.
Breast cancer research and treatment 2000;64(3):259-67.
2000: Slotkin T A; Ferguson S A; Cada A M; McCook E C; Seidler F J
Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth.
Brain research 2000;887(1):16-22.
2000: Slotkin T A; Pinkerton K E; Seidler F J
Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.
Brain research. Developmental brain research 2000;124(1-2):53-8.
2000: Slotkin T A; Seidler F J; Ritchie J C
Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: effects of olfactory bulbectomy in young versus aged rats.
Brain research 2000;882(1-2):149-54.
2000: Trauth J A; Seidler F J; Slotkin T A
Persistent and delayed behavioral changes after nicotine treatment in adolescent rats.
Brain research 2000;880(1-2):167-72.
2000: Slotkin T A; Seidler F J; Ali S F
Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions.
Brain research 2000;879(1-2):163-73.
2000: Chow F A; Seidler F J; McCook E C; Slotkin T A
Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase.
Brain research 2000;878(1-2):119-26.
2000: Trauth J A; McCook E C; Seidler F J; Slotkin T A
Modeling adolescent nicotine exposure: effects on cholinergic systems in rat brain regions.
Brain research 2000;873(1):18-25.
2000: Crumpton T L; Seidler F J; Slotkin T A
Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
Brain research. Developmental brain research 2000;121(2):189-95.
2000: Dam K; Seidler F J; Slotkin T A
Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.
Brain research. Developmental brain research 2000;121(2):179-87.
2000: Trauth J A; Seidler F J; Slotkin T A
An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions.
Brain research 2000;867(1-2):29-39.
2000: Auman J T; Seidler F J; Slotkin T A
Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity.
Brain research. Developmental brain research 2000;121(1):19-27.
2000: Zeiders J L; Seidler F J; Slotkin T A
Ontogeny of G-protein expression: control by beta-adrenoceptors.
Brain research. Developmental brain research 2000;120(2):125-34.
2000: Slotkin T A; Zhang J; Dancel R; Garcia S J; Willis C; Seidler F J
Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.
Breast cancer research and treatment 2000;60(2):153-66.
2000: Crumpton T L; Seidler F J; Slotkin T A
Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.
Brain research 2000;857(1-2):87-98.
1999: Trauth J A; Seidler F J; McCook E C; Slotkin T A
Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions.
Brain research 1999;851(1-2):9-19.
1999: Dam K; Seidler F J; Slotkin T A
Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes.
Brain research. Developmental brain research 1999;118(1-2):129-33.
1999: Zeiders J L; Seidler F J; Slotkin T A
Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase.
The Journal of pharmacology and experimental therapeutics 1999;291(2):503-10.
1999: Dam K; Garcia S J; Seidler F J; Slotkin T A
Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.
Brain research. Developmental brain research 1999;116(1):9-20.
1999: Slotkin T A; Miller D B; Fumagalli F; McCook E C; Zhang J; Bissette G; Seidler F J
Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats.
The Journal of pharmacology and experimental therapeutics 1999;289(1):334-45.
1999: Slotkin T A; Epps T A; Stenger M L; Sawyer K J; Seidler F J
Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality.
Brain research. Developmental brain research 1999;113(1-2):1-12.
1999: Zeiders J L; Seidler F J; Iaccarino G; Koch W J; Slotkin T A
Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling.
Journal of molecular and cellular cardiology 1999;31(2):413-23.
1999: Trauth J A; Seidler F J; McCook E C; Slotkin T A
Persistent c-fos induction by nicotine in developing rat brain regions: interaction with hypoxia.
Pediatric research 1999;45(1):38-45.
1998: Roy T S; Andrews J E; Seidler F J; Slotkin T A
Nicotine evokes cell death in embryonic rat brain during neurulation.
The Journal of pharmacology and experimental therapeutics 1998;287(3):1136-44.
1998: Slotkin T A; Seidler F J; Ritchie J C
Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: therapeutic implications.
Brain research bulletin 1998;47(4):345-8.
1998: Slotkin T A; Zhang J; McCook E C; Seidler F J
Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.
Brain research. Developmental brain research 1998;111(1):11-24.
1998: Roy T S; Andrews J E; Seidler F J; Slotkin T A
Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos.
Teratology 1998;58(2):62-8.
1998: Slotkin T A; Zhang J; McCook E C; Seidler F J
Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats.
Brain research 1998;800(2):236-44.
1998: Song X; Violin J D; Seidler F J; Slotkin T A
Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.
Toxicology and applied pharmacology 1998;151(1):182-91.
1998: Dam K; Seidler F J; Slotkin T A
Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.
Brain research. Developmental brain research 1998;108(1-2):39-45.
1998: Johnson D E; Seidler F J; Slotkin T A
Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.
Brain research bulletin 1998;45(2):143-7.
1997: McGrath K E; Seidler F J; Slotkin T A
Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain.
Brain research. Developmental brain research 1997;104(1-2):209-13.
1997: Song X; Seidler F J; Saleh J L; Zhang J; Padilla S; Slotkin T A
Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.
Toxicology and applied pharmacology 1997;145(1):158-74.
1997: Tan J P; Seidler F J; Schwinn D A; Page S O; Slotkin T A
A critical period for the role of thyroid hormone in development of renal alpha-adrenergic receptors.
Pediatric research 1997;42(1):93-102.
1997: Slotkin T A; Saleh J L; McCook E C; Seidler F J
Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome.
Teratology 1997;55(3):177-84.
1997: Slotkin T A; McCook E C; Seidler F J
Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression.
Brain research 1997;750(1-2):180-8.
1997: Slotkin T A; Wang X F; Symonds H S; Seidler F J
Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain.
Brain research. Developmental brain research 1997;99(1):61-5.
1997: Renick S E; Seidler F J; McCook E C; Slotkin T A
Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy.
Pediatric research 1997;41(3):359-63.
1997: Zeiders J L; Seidler F J; Slotkin T A
Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.
Journal of molecular and cellular cardiology 1997;29(2):603-15.
1997: Slotkin T A; McCook E C; Ritchie J C; Carroll B J; Seidler F J
Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects.
Biological psychiatry 1997;41(2):172-83.
1997: Campbell C G; Seidler F J; Slotkin T A
Chlorpyrifos interferes with cell development in rat brain regions.
Brain research bulletin 1997;43(2):179-89.
1996: Slotkin T A; Saleh J L; Zhang J; Seidler F J
Ontogeny of beta-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation.
Brain research 1996;742(1-2):317-28.
1996: Slotkin T A; Thai L; McCook E C; Saleh J L; Zhang J; Seidler F J
Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase.
The Journal of pharmacology and experimental therapeutics 1996;279(2):478-91.
1996: Slotkin T A; McCook E C; Ritchie J C; Seidler F J
Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model.
Biological psychiatry 1996;40(7):576-84.
1996: Slotkin T A; Barnes G A; McCook E C; Seidler F J
Programming of brainstem serotonin transporter development by prenatal glucocorticoids.
Brain research. Developmental brain research 1996;93(1-2):155-61.
1996: Fumagalli F; Jones S R; Caron M G; Seidler F J; Slotkin T A
Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.
Brain research 1996;719(1-2):225-8.
1996: Metz L D; Seidler F J; McCook E C; Slotkin T A
Cardiac alpha-adrenergic receptor expression is regulated by thyroid hormone during a critical developmental period.
Journal of molecular and cellular cardiology 1996;28(5):1033-44.
1996: Thai L; Galluzzo J M; McCook E C; Seidler F J; Slotkin T A
Atypical regulation of hepatic adenylyl cyclase and adrenergic receptors during a critical developmental period: agonists evoke supersensitivity accompanied by failure of receptor down-regulation.
Pediatric research 1996;39(4 Pt 1):697-707.
1996: Bissette G; Seidler F J; Nemeroff C B; Slotkin T A
High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy.
Annals of the New York Academy of Sciences 1996;777():197-204.
1995: Tolson C M; Seidler F J; McCook E C; Slotkin T A
Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage?
Teratology 1995;52(5):298-305.
1995: Giannuzzi C E; Seidler F J; Slotkin T A
Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization.
Brain research 1995;694(1-2):271-8.
1995: Whitney K D; Seidler F J; Slotkin T A
Developmental neurotoxicity of chlorpyrifos: cellular mechanisms.
Toxicology and applied pharmacology 1995;134(1):53-62.
1995: Slotkin T A; Lappi S E; Seidler F J
Beta-adrenergic control of c-fos expression in fetal and neonatal rat tissues: relationship to cell differentiation and teratogenesis.
Toxicology and applied pharmacology 1995;133(2):188-95.
1995: Slotkin T A; Lorber B A; McCook E C; Barnes G A; Seidler F J
Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase.
Brain research. Developmental brain research 1995;88(1):17-29.
1995: Wagner J P; Seidler F J; Lappi S E; McCook E C; Slotkin T A
Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression.
The Journal of pharmacology and experimental therapeutics 1995;273(1):415-26.
1995: Seidler F J; Temple S W; McCook E C; Slotkin T A
Cocaine inhibits central noradrenergic and dopaminergic activity during the critical developmental period in which catecholamines influence cell development.
Brain research. Developmental brain research 1995;85(1):48-53.
1995: Rao G S; Seidler F J; Slotkin T A
Modulation of hepatic adrenergic receptor ontogeny by thyroid hormone.
Research communications in molecular pathology and pharmacology 1995;87(1):27-42.
1995: Schachat F; Seidler F J; Slotkin T A
The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP.
Reproduction, fertility, and development 1995;7(5):1361-7.
1995: Slotkin T A; Lappi S E; McCook E C; Lorber B A; Seidler F J
Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.
Brain research bulletin 1995;38(1):69-75.
1994: Slotkin T A; Lau C; Seidler F J
Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins.
Toxicology and applied pharmacology 1994;129(2):223-34.
1994: Wagner J P; Seidler F J; Lappi S E; McCook E C; Slotkin T A
Role of thyroid status in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase, ornithine decarboxylase and c-fos protooncogene expression.
The Journal of pharmacology and experimental therapeutics 1994;271(1):472-83.
1994: Seidler F J; Albright E S; Lappi S E; Slotkin T A
In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions.
Brain research. Developmental brain research 1994;82(1-2):1-8.
1994: Slotkin T A; Nemeroff C B; Bissette G; Seidler F J
Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies.
The Journal of clinical investigation 1994;94(2):696-702.
1994: Slotkin T A; Lau C; McCook E C; Lappi S E; Seidler F J
Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization?
Toxicology and applied pharmacology 1994;127(1):64-75.
1994: Wagner J P; Seidler F J; Schachat F H; Slotkin T A
beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions.
The Journal of pharmacology and experimental therapeutics 1994;269(3):1292-9.
1994: Kauffman K S; Seidler F J; Slotkin T A
Prenatal dexamethasone exposure causes loss of neonatal hypoxia tolerance: cellular mechanisms.
Pediatric research 1994;35(5):515-22.
1994: Spraggins Y R; Seidler F J; Slotkin T A
Cocaine exacerbates hypoxia-induced cell damage in the developing brain: effects on ornithine decarboxylase activity and protein synthesis.
Biology of the neonate 1994;66(5):254-66.
1993: Bian X; Seidler F J; Olsen C; Raymond J R; Slotkin T A
Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein.
Teratology 1993;48(2):169-77.
1993: Zahalka E A; Seidler F J; Slotkin T A
Dexamethasone treatment in utero enhances neonatal cholinergic nerve terminal development in rat brain.
Research communications in chemical pathology and pharmacology 1993;81(2):191-8.
1993: Wood M W; Seidler F J; Slotkin T A
Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.
Research communications in chemical pathology and pharmacology 1993;80(3):323-8.
1993: Zahalka E A; Seidler F J; Yanai J; Slotkin T A
Fetal nicotine exposure alters ontogeny of M1-receptors and their link to G-proteins.
Neurotoxicology and teratology 1993;15(2):107-15.
1993: Yanai J; Rogel-Fuchs Y; Pick C G; Slotkin T; Seidler F J; Zahalka E A; Newman M E
Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.
Neuropharmacology 1993;32(2):113-7.
1993: Bian X; Seidler F J; Slotkin T A
Fetal dexamethasone exposure interferes with establishment of cardiac noradrenergic innervation and sympathetic activity.
Teratology 1993;47(2):109-17.
1993: Zahalka E A; Seidler F J; Lappi S E; Yanai J; Slotkin T A
Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression.
Brain research 1993;601(1-2):221-9.
1993: Slotkin T A; Lappi S E; Seidler F J
Impact of fetal nicotine exposure on development of rat brain regions: critical sensitive periods or effects of withdrawal?
Brain research bulletin 1993;31(3-4):319-28.
1993: Seidler F J; Slotkin T A
Prenatal cocaine and cell development in rat brain regions: effects on ornithine decarboxylase and macromolecules.
Brain research bulletin 1993;30(1-2):91-9.
1993: Slotkin T A; Johnson D J; Seidler F J
Acute effects of cocaine on ornithine decarboxylase activity in fetal and neonatal rat heart: evidence for cardiotoxicity.
Biology of the neonate 1993;63(5):290-6.
1993: Slotkin T A; McCook E C; Seidler F J
Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure.
Brain research bulletin 1993;32(4):359-64.
1992: Zahalka E A; Seidler F J; Lappi S E; McCook E C; Yanai J; Slotkin T A
Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding.
Neurotoxicology and teratology 1992;14(6):375-82.
1992: Seidler F J; Slotkin T A
Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors.
The Journal of pharmacology and experimental therapeutics 1992;263(2):413-21.
1992: Seidler F J; Levin E D; Lappi S E; Slotkin T A
Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.
Brain research. Developmental brain research 1992;69(2):288-91.
1992: Pracyk J B; Seidler F J; McCook E C; Slotkin T A
Pituitary-thyroid axis reactivity to hyper- and hypothyroidism in the perinatal period: ontogeny of regulation of regulation and long-term programming of responses.
Journal of developmental physiology 1992;18(3):105-9.
1992: Slotkin T A; McCook E C; Lappi S E; Seidler F J
Altered development of basal and forskolin-stimulated adenylate cyclase activity in brain regions of rats exposed to nicotine prenatally.
Brain research. Developmental brain research 1992;68(2):233-9.
1992: Carlos R Q; Seidler F J; Slotkin T A
Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: a critical period for regionally selective alterations?
Teratology 1992;46(1):45-59.
1992: Bian X; Briggs M M; Schachat F H; Seidler F J; Slotkin T A
Glucocorticoids accelerate the ontogenetic transition of cardiac ventricular myosin heavy-chain isoform expression in the rat: promotion by prenatal exposure to a low dose of dexamethasone.
Journal of developmental physiology 1992;18(1):35-42.
1992: Slotkin T A; Seidler F J
Transient postnatal elevation of norepinephrine content and turnover in brain regions of rats exposed to terbutaline prenatally: evidence for autoregulation of noradrenergic development?
Research communications in chemical pathology and pharmacology 1992;76(3):269-78.
1992: Bian X P; Seidler F J; Slotkin T A
Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure.
Journal of developmental physiology 1992;17(6):289-97.
1992: Briggs M M; Seidler F J; Slotkin T A; Schachat F H
Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exposure to beta-adrenergic agonists or antagonists.
Journal of developmental physiology 1992;17(4):201-6.
1992: Lin W; Seidler F J; McCook E C; Slotkin T A
Overexpression of alpha 2-adrenergic receptors in fetal rat heart: receptors in search of a function.
Journal of developmental physiology 1992;17(4):183-7.
1992: Slotkin T A; Seidler F J; Kavlock R J; Bartolome J V
Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney.
Teratology 1992;45(3):303-12.
1992: Slotkin T A; Seidler F J; Kavlock R J; Gray J A
Fetal dexamethasone exposure accelerates development of renal function: relationship to dose, cell differentiation and growth inhibition.
Journal of developmental physiology 1992;17(2):55-61.
1992: Slotkin T A; Lappi S E; McCook E C; Tayyeb M I; Eylers J P; Seidler F J
Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity.
Biology of the neonate 1992;61(5):326-36.
1991: Carlos R Q; Seidler F J; Slotkin T A
Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis.
Brain research. Developmental brain research 1991;64(1-2):161-6.
1991: Koegler S M; Seidler F J; Spencer J R; Slotkin T A
Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat.
Brain research bulletin 1991;27(6):829-34.
1991: Nye H E; Seidler F J; Slotkin T A
Developmental shift from local to central control of norepinephrine release in the cardiac-sympathetic axis: effects of cocaine and related drugs.
The Journal of pharmacology and experimental therapeutics 1991;259(3):976-81.
1991: Bian X P; Seidler F J; Slotkin T A
Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure.
Journal of developmental physiology 1991;16(6):331-9.
1991: Smith W T; Seidler F J; Slotkin T A
Acute stimulation of ornithine decarboxylase in neonatal rat brain regions by nicotine: a central receptor-mediated process?
Brain research. Developmental brain research 1991;63(1-2):85-93.
1991: Slotkin T A; Lappi S E; Tayyeb M I; Seidler F J
Dose-dependent glucocorticoid effects on noradrenergic synaptogenesis in rat brain: ontogeny of [3H]desmethylimipramine binding sites after fetal exposure to dexamethasone.
Research communications in chemical pathology and pharmacology 1991;73(1):3-19.
1991: Slotkin T A; McCook E C; Nemeroff C B; Seidler F J
Species differences in alpha 2-adrenergic regulation of platelet adenylate cyclase.
Research communications in chemical pathology and pharmacology 1991;72(3):259-71.
1991: Wagner J P; Seidler F J; Slotkin T A
Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.
Brain research bulletin 1991;26(6):885-90.
1991: Slotkin T A; Seidler F J; Kavlock R J; Bartolome J V
Fetal dexamethasone exposure impairs cellular development in neonatal rat heart and kidney: effects on DNA and protein in whole tissues.
Teratology 1991;43(4):301-6.
1991: McFarland B J; Seidler F J; Slotkin T A
Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration.
Brain research. Developmental brain research 1991;58(2):223-9.
1991: Duncan C P; Seidler F J; Slotkin T A
Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions.
Brain research. Developmental brain research 1991;58(1):67-71.
1991: Slotkin T A; Lappi S E; Tayyeb M I; Seidler F J
Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase.
Life sciences 1991;49(9):665-70.
1991: Huff R A; Seidler F J; Slotkin T A
Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.
Life sciences 1991;48(11):1059-65.
1991: Nemeroff C B; Bissette G; Slotkin T A; Seidler F J; Miller B E; Ghanbari H
Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.
Annals of the New York Academy of Sciences 1991;640():193-6.
1990: Anderson-Brown T; Slotkin T A; Seidler F J
Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions.
Brain research 1990;537(1-2):197-202.
1990: Bian X P; Seidler F J; Bartolome J; Kavlock R J; Bartolome M; Slotkin T A
Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP.
Journal of developmental physiology 1990;14(3):125-30.
1990: Navarro H A; Mills E; Seidler F J; Baker F E; Lappi S E; Tayyeb M I; Spencer J R; Slotkin T A
Prenatal nicotine exposure impairs beta-adrenergic function: persistent chronotropic subsensitivity despite recovery from deficits in receptor binding.
Brain research bulletin 1990;25(2):233-7.
1990: Duncan C P; Seidler F J; Lappi S E; Slotkin T A
Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain.
Brain research. Developmental brain research 1990;55(1):29-33.
1990: Slotkin T A; Seidler F J; Crain B J; Bell J M; Bissette G; Nemeroff C B
Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2452-5.
1990: Seidler F J; Slotkin T A
Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover.
Brain research bulletin 1990;24(2):157-61.
1990: Seidler F J; Bell J M; Slotkin T A
Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions.
Pediatric research 1990;27(2):191-7.
1990: Slotkin T A; Kudlacz E M; Lappi S E; Tayyeb M I; Seidler F J
Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding.
Life sciences 1990;47(22):2051-7.
1990: Slotkin T A; Navarro H A; McCook E C; Seidler F J
Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.
Life sciences 1990;47(17):1561-7.
1989: Navarro H A; Seidler F J; Eylers J P; Baker F E; Dobbins S S; Lappi S E; Slotkin T A
Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain.
The Journal of pharmacology and experimental therapeutics 1989;251(3):894-900.
1989: Sylvia A L; Seidler F J; Slotkin T A
Effect of transient hypoxia on oxygenation of the developing rat brain: relationships among haemoglobin saturation, autoregulation of blood flow and mitochondrial redox state.
Journal of developmental physiology 1989;12(5):287-92.
1989: Slotkin T A; Baker F E; Dobbins S S; Eylers J P; Lappi S E; Seidler F J
Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.
Brain research bulletin 1989;23(4-5):263-5.
1989: Navarro H A; Seidler F J; Schwartz R D; Baker F E; Dobbins S S; Slotkin T A
Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.
Brain research bulletin 1989;23(3):187-92.
1989: Hou Q C; Seidler F J; Slotkin T A
Development of the linkage of beta-adrenergic receptors to cardiac hypertrophy and heart rate control: neonatal sympathectomy with 6-hydroxydopamine.
Journal of developmental physiology 1989;11(5):305-11.
1989: Hou Q C; Baker F E; Seidler F J; Bartolome M; Bartolome J; Slotkin T A
Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment.
Journal of developmental physiology 1989;11(3):139-46.
1989: Seidler F J; Mills E
Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat.
Life sciences 1989;45(5):379-81.
1988: Slotkin T A; Seidler F J; Haim K; Cameron A M; Antolick L; Lau C
Neonatal central catecholaminergic lesions with intracisternal 6-hydroxydopamine: effects on development of presynaptic and postsynaptic components of peripheral sympathetic pathways and on the ornithine decarboxylase/polyamine system in heart, lung and kidney.
The Journal of pharmacology and experimental therapeutics 1988;247(3):975-82.
1988: Slotkin T A; Windh R; Whitmore W L; Seidler F J
Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.
Brain research bulletin 1988;21(5):737-40.
1988: Lau C; Seidler F J; Cameron A M; Navarro H A; Bell J M; Bartolome J; Slotkin T A
Nutritional influences on adrenal chromaffin cell development: comparison with central neurons.
Pediatric research 1988;24(5):583-7.
1988: Navarro H A; Seidler F J; Whitmore W L; Slotkin T A
Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems.
The Journal of pharmacology and experimental therapeutics 1988;244(3):940-4.
1988: Slotkin T A; Seidler F J
Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival.
Journal of developmental physiology 1988;10(1):1-16.
1988: Slotkin T A; Seidler F J
Stress in the fetus and newborn.
Advances in experimental medicine and biology 1988;245():283-94.
1986: Bell J M; Whitmore W L; Barnes G; Seidler F J; Slotkin T A
Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1986;4(6):497-501.
1982: Slotkin T A; Weigel S J; Seidler F J; Whitmore W L
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Toxicology letters 1982;14(3-4):131-5.
1982: Grignolo A; Seidler F J; Bartolome M; Kuhn C M; Slotkin T A; Schanberg S M
Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.
Life sciences 1982;31(26):3009-16.
1982: Slotkin T A; Seidler F J; Trepanier P A; Whitmore W L; Lerea L; Barnes G A; Weigel S J; Bartolome J
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
The Journal of pharmacology and experimental therapeutics 1982;222(3):741-5.
1982: Slotkin T A; Grignolo A; Whitmore W L; Lerea L; Trepanier P A; Barnes G A; Weigel S J; Seidler F J; Bartolome J
Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
The Journal of pharmacology and experimental therapeutics 1982;222(3):746-51.
1982: Bartolome J; Trepanier P; Chait E A; Seidler F J; Deskin R; Slotkin T A
Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems.
Toxicology and applied pharmacology 1982;65(1):92-9.
1982: Slotkin T A; Barnes G; Lau C; Seidler F J; Trepanier P; Weigel S J; Whitmore W L
Development of polyamine and biogenic amine systems in brains and hearts of neonatal rats given dexamethasone: role of biochemical alterations in cellular maturation for producing deficits in ontogeny of neurotransmitter levels, uptake, storage and turnover.
The Journal of pharmacology and experimental therapeutics 1982;221(3):686-93.
1982: Slotkin T A; Weigel S J; Whitmore W L; Seidler F J
Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.
Biochemical pharmacology 1982;31(10):1899-902.
1981: Slotkin T A; Weigel S J; Barnes G A; Whitmore W L; Seidler F J
Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems.
Life sciences 1981;29(24):2519-25.

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