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Christine Seidman

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Bradley M Palmer; Joachim P Schmitt; Christine E Seidman; Jonathan G Seidman; Yuan Wang; Stephen P Bell; Martin M LeWinter; David Wayne Maughan
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.
Akl C Fahed; Bruce D Gelb; Jonathan G Seidman; Christine E Seidman
Genetics of congenital heart disease: the glass half empty.
Polakit Teekakirikul; Jonathan G Seidman; Robert F Padera; Christine E Seidman
Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics.

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2013: Bradley M Palmer; Joachim P Schmitt; Christine E Seidman; Jonathan G Seidman; Yuan Wang; Stephen P Bell; Martin M LeWinter; David Wayne Maughan
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.
Journal of molecular and cellular cardiology 2013;57():23-31.
2013: Akl C Fahed; Bruce D Gelb; Jonathan G Seidman; Christine E Seidman
Genetics of congenital heart disease: the glass half empty.
Circulation research 2013;112(4):707-20.
2012: Polakit Teekakirikul; Jonathan G Seidman; Robert F Padera; Christine E Seidman
Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics.
The Journal of cell biology 2012;199(3):417-21.
2012: Neal K Lakdawala; Barbara McDonough; E John Orav; Jose Rivero; Christine E Seidman; Jonathan G Seidman; Elizabeth Sparks; Jens jakob Thune; Allison L Cirino; Steven D Colan; Faranak Farrohi; Carolyn Y Ho
Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy.
Circulation. Cardiovascular genetics 2012;5(5):503-10.
2012: Kasper Lage; Blake C Ballif; Søren Brunak; Mark J Daly; Patricia K Donahoe; Joshua M Gorham; Steven C Greenway; Sonia M Mesquita; William T Pu; Amy E Roberts; Jill A Rosenfeld; Ayellet V Segrè; Christine E Seidman; Jonathan G Seidman; Lisa G Shaffer; Leslie B Smoot; Niels Tommerup; Hiroko Wakimoto; Alexandre C Pereira; Lars A Larsen
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14035-40.
2012: Tatianna C Larman; Alexei Protopopov; Christine E Seidman; Lynda Chin; Steven R Depalma; Stacey B Gabriel; Angela G Hadjipanayis; Raju Kucherlapati; Jianhua Zhang; Jonathan G Seidman
Spectrum of somatic mitochondrial mutations in five cancers.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14087-91.
2012: Neal K Lakdawala; Nancy J Mendelsohn; Chantal Morel; Apostolos Psychogios; Heidi L Rehm; Amy E Roberts; Christine E Seidman; Jonathan G Seidman; Emily White; Samantha Baxter; Melanie Care; Wendy K Chung; Allison L Cirino; Elizabeth Duffy; Birgit Funke; Nicole Johnson; Carolyn Jones; Daniel P Judge; Carolyn Y Ho
Genetic testing for dilated cardiomyopathy in clinical practice.
Journal of cardiac failure 2012;18(4):296-303.
2012: Daniel S Herman; Carolyn Y Ho; Neal K Lakdawala; Lien Lam; Barbara McDonough; Marco Merlo; Luisa Mestroni; Richard N Mitchell; Charles E Murry; Dudley J Pennell; Michael J Ackerman; Nicholas R Banner; Paul J R Barton; J Martijn Bos; Danos Christodoulou; Allison L Cirino; Lauren Conner; Stuart A Cook; Steven R Depalma; Andrea Di Lenarda; Sharon L Graw; Jonathan G Seidman; Gianfranco Sinagra; Elizabeth Sparks; Matthew R G Taylor; Polakit Teekakirikul; Debbie Lin Teodorescu; Libin Wang; Christine E Seidman
Truncations of titin causing dilated cardiomyopathy.
The New England journal of medicine 2012;366(7):619-28.
2011: Christine E Seidman; Jonathan G Seidman
Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history.
Circulation research 2011;108(6):743-50.
2011: Ronny Alcalai; Hiroko Wakimoto; Michael Arad; David Planer; Tetsuo Konno; Libin Wang; Jon G Seidman; Christine E Seidman; Charles I Berul
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
Journal of cardiovascular electrophysiology 2011;22(3):316-24.
2011: Amanda A Fox; David A Hafler; Daniel S Herman; Kuang-Yu Liu; Jochen Muehlschlegel; Tjorvi E Perry; Mias Pretorius; Dan M Roden; Simon Body; Charles Collard; Dawood Darbar; Philip De Jager; Steven R Depalma; Brian S Donahue; Jonathan G Seidman; Stanton K Shernan; Christine E Seidman
Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.
PloS one 2011;6(9):e24593.
2010: Tetsuo Konno; Dan Chen; Libin Wang; Hiroko Wakimoto; Polakit Teekakirikul; Matthew Nayor; Masataka Kawana; Seda Eminaga; Joshua M Gorham; Kumar Pandya; Oliver Smithies; Francisco J Naya; Eric N Olson; Jonathan G Seidman; Christine E Seidman
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18097-102.
2010: Polakit Teekakirikul; Seda Eminaga; Okan Toka; Ronny Alcalai; Libin Wang; Hiroko Wakimoto; Matthew Nayor; Tetsuo Konno; Joshua M Gorham; Cordula M Wolf; Jae B Kim; Joachim P Schmitt; Jefferey D Molkentin; Russell A Norris; Andrew M Tager; Stanley R Hoffman; Roger R Markwald; Christine E Seidman; Jonathan G Seidman
Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.
The Journal of clinical investigation 2010;120(10):3520-9.
2010: Carolyn Y Ho; Begoña López; Otavio R Coelho-Filho; Neal K Lakdawala; Allison L Cirino; Petr Jarolim; Raymond Kwong; Arantxa González; Steven D Colan; Jonathan G Seidman; Javier Díez; Christine E Seidman
Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy.
The New England journal of medicine 2010;363(6):552-63.
2010: Libin Wang; Jonathan G Seidman; Christine E Seidman
Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.
Annals of internal medicine 2010;152(8):513-20, W181.
2010: Neal K Lakdawala; Lisa Dellefave; Charles S Redwood; Elizabeth Sparks; Allison L Cirino; Steven R Depalma; Steven D Colan; Birgit Funke; Rebekah S Zimmerman; Paul Robinson; Hugh Watkins; Christine E Seidman; Jonathan G Seidman; Elizabeth McNally; Carolyn Y Ho
Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.
Journal of the American College of Cardiology 2010;55(4):320-9.
2009: Li-bin Wang; J G Seidman; Christine E Seidman
[Using molecular genetics to guide the diagnosis and treatment of hypertrophic cardiomyopathy].
Zhonghua xin xue guan bing za zhi 2009;37(12):1063-8.
2009: Fayez Bahmad; Steven R Depalma; Saumil N Merchant; Roberta L Bezerra; Carlos A Oliveira; Christine E Seidman; Jonathan G Seidman
Locus for familial migrainous vertigo disease maps to chromosome 5q35.
The Annals of otology, rhinology, and laryngology 2009;118(9):670-6.
2009: Steven C Greenway; Alexandre C Pereira; Jennifer C Lin; Steven R Depalma; Samuel J Israel; Sonia M Mesquita; Emel Ergul; Jessie H Conta; Joshua M Korn; Steven A McCarroll; Joshua M Gorham; Stacey Gabriel; David Altshuler; Maria de Lourdes Quintanilla-Dieck; Maria Alexandra Artunduaga; Roland D Eavey; Robert M Plenge; Nancy A Shadick; Michael E Weinblatt; Philip De Jager; David A Hafler; Roger E Breitbart; Jonathan G Seidman; Christine E Seidman
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
Nature genetics 2009;41(8):931-5.
2009: Daniel S Herman; G Kees Hovingh; Oleg Iartchouk; Heidi L Rehm; Raju Kucherlapati; Jonathan G Seidman; Christine E Seidman
Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection.
Nature methods 2009;6(7):507-10.
2009: Teresa Santiago-Sim; Sumy Mathew-Joseph; Hariyadarshi Pannu; Dianna M Milewicz; Christine E Seidman; Jonathan G Seidman; Dong H Kim
Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.
Stroke; a journal of cerebral circulation 2009;40(5):1604-11.
2009: Lori Nyland; Bradley M Palmer; Zengyi Chen; David Wayne Maughan; Christine E Seidman; Jonathan G Seidman; Laurent Kreplak; Jim O Vigoreaux
Cardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidity.
Biophysical journal 2009;96(8):3273-80.
2008: Libin Wang; William F Sewell; Sang D Kim; Jordan T Shin; Calum A MacRae; Leonard I Zon; Jonathan G Seidman; Christine E Seidman
Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.
Development (Cambridge, England) 2008;135(20):3425-34.
2008: Hiroyuki Morita; Heidi L Rehm; Andres Menesses; Barbara McDonough; Amy E Roberts; Raju Kucherlapati; Jeffrey A Towbin; Jonathan G Seidman; Christine E Seidman
Shared genetic causes of cardiac hypertrophy in children and adults.
The New England journal of medicine 2008;358(18):1899-908.
2008: Bradley M Palmer; Yuan Wang; Polakit Teekakirikul; J Travis Hinson; Diane Fatkin; Stacy Strouse; Peter VanBuren; Christine E Seidman; Jonathan G Seidman; David Wayne Maughan
Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
American journal of physiology. Heart and circulatory physiology 2008;294(4):H1939-47.
2008: Frederic F S Depreux; Keith Darrow; David A Conner; Roland D Eavey; M Charles Liberman; Christine E Seidman; Jonathan G Seidman
Eya4-deficient mice are a model for heritable otitis media.
The Journal of clinical investigation 2008;118(2):651-8.
2008: Cordula M Wolf; Libin Wang; Ronny Alcalai; Anne Pizard; Patrick G Burgon; Ferhaan Ahmad; Megan C Sherwood; Dorothy Branco; Hiroko Wakimoto; Glenn I Fishman; Vincent See; Colin L Stewart; David A Conner; Charles I Berul; Christine E Seidman; Jonathan G Seidman
Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.
Journal of molecular and cellular cardiology 2008;44(2):293-303.
2008: Cordula M Wolf; Michael Arad; Ferhaan Ahmad; Atsushi Sanbe; Scott A Bernstein; Okan Toka; Tetsuo Konno; Gregory E Morley; Jeffrey Robbins; Jonathan G Seidman; Christine E Seidman; Charles I Berul
Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations.
Circulation 2008;117(2):144-54.
2008: Ronny Alcalai; Jonathan G Seidman; Christine E Seidman
Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics.
Journal of cardiovascular electrophysiology 2008;19(1):104-10.
2007: Lei Song; Ronny Alcalai; Michael Arad; Cordula M Wolf; Okan Toka; David A Conner; Charles I Berul; Michael Eldar; Christine E Seidman; Jonathan G Seidman
Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
The Journal of clinical investigation 2007;117(7):1814-23.
2007: Edward P Debold; Joachim P Schmitt; Joseph B Patlak; S E Beck; Jeffrey R Moore; Jonathan G Seidman; Christine E Seidman; David M Warshaw
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H284-91.
2007: Ivan P G Moskowitz; Jae B Kim; Meredith L Moore; Cordula M Wolf; Michael A Peterson; Jay Shendure; Marcelo A Nobrega; Yoshifumi Yokota; Charles I Berul; Seigo Izumo; Jonathan G Seidman; Christine E Seidman
A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Cell 2007;129(7):1365-76.
2007: Jae Bum Kim; Gregory J Porreca; Lei Song; Steven C Greenway; Joshua M Gorham; George M Church; Christine E Seidman; Jonathan G Seidman
Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy.
Science (New York, N.Y.) 2007;316(5830):1481-4.
2007: Ivan Luptak; Mei Shen; Huamei He; Michael F Hirshman; Nicolas Musi; Laurie J Goodyear; Jie Yan; Hiroko Wakimoto; Hiroyuki Morita; Michael Arad; Christine E Seidman; Jonathan G Seidman; Joanne S Ingwall; James Balschi; Rong Tian
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.
The Journal of clinical investigation 2007;117(5):1432-9.
2007: J Travis Hinson; Valeria R Fantin; Jost Schönberger; Noralv Breivik; Geir Siem; Barbara McDonough; Pankaj Sharma; Ivan J Keogh; Ricardo N Godinho; Felipe Santos; Alfonso Esparza; Yamileth Nicolau; Edgar Selvaag; Bruce Howard Cohen; Charles L Hoppel; Lisbeth Tranebjaerg; Roland D Eavey; Jonathan G Seidman; Christine E Seidman
Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome.
The New England journal of medicine 2007;356(8):809-19.
2006: Joachim P Schmitt; Edward P Debold; Ferhaan Ahmad; Amy Armstrong; Andrea Frederico; David A Conner; Ulrike Mende; Martin J Lohse; David M Warshaw; Christine E Seidman; Jonathan G Seidman
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14525-30.
2006: Alessandro Mori; Yonghong Zhu; Ilyas Vahora; Brian J Nieman; Kazuko Koshiba-Takeuchi; Lorinda Davidson; Anne Pizard; Jonathan G Seidman; Christine E Seidman; X Josette Chen; R Mark Henkelman; Benoit G Bruneau
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Developmental biology 2006;297(2):566-86.
2006: Carolyn Y Ho; Christine E Seidman
A contemporary approach to hypertrophic cardiomyopathy.
Circulation 2006;113(24):e858-62.
2006: Hiroyuki Morita; Martin G Larson; Scott C Barr; Ramachandran S Vasan; Christopher J O'Donnell; Joel N Hirschhorn; Daniel Levy; Diane Corey; Christine E Seidman; Jonathan G Seidman; Emelia Benjamin
Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Circulation 2006;113(23):2697-705.
2006: Lei Song; Steven R Depalma; Maria Kharlap; Andrey G Zenovich; Allison L Cirino; Richard Mitchell; Barbara McDonough; Barry J Maron; Christine E Seidman; Jonathan G Seidman; Carolyn Y Ho
Novel locus for an inherited cardiomyopathy maps to chromosome 7.
Circulation 2006;113(18):2186-92.
2006: Marc S Sabatine; Jonathan G Seidman; Christine E Seidman
Cardiovascular genomics.
Circulation 2006;113(11):e450-5.
2006: Mitsuhiro Kamisago; Joachim P Schmitt; Dennis McNamara; Christine E Seidman; Jonathan G Seidman
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Novartis Foundation symposium 2006;274():176-89; discussion 189-95, 272-6.
2005: Cordula M Wolf; Ivan P G Moskowitz; Scott Arno; Dorothy Branco; Christopher Semsarian; Scott A Bernstein; Michael Peterson; Michael Maida; Gregory E Morley; Glenn Fishman; Charles I Berul; Christine E Seidman; Jonathan G Seidman
Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18123-8.
2005: Ferhaan Ahmad; Michael Arad; Nicolas Musi; Huamei He; Cordula Wolf; Dorothy Branco; Antonio R Perez-Atayde; David Stapleton; Deeksha Bali; Yanqiu Xing; Rong Tian; Laurie J Goodyear; Charles I Berul; Joanne S Ingwall; Christine E Seidman; Jonathan G Seidman
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
Circulation 2005;112(20):3140-8.
2005: Michael Arad; Manuel Penas Lado; Lorenzo Monserrat; Barry J Maron; Mark Sherrid; Carolyn Y Ho; Scott Barr; Ahmad Karim; Timothy M Olson; Mitsuhiro Kamisago; Jonathan G Seidman; Christine E Seidman
Gene mutations in apical hypertrophic cardiomyopathy.
Circulation 2005;112(18):2805-11.
2005: Liqun Zou; Mei Shen; Michael Arad; Huamei He; Bo Løfgren; Joanne S Ingwall; Christine E Seidman; Jonathan G Seidman; Rong Tian
N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity.
Circulation research 2005;97(4):323-8.
2005: Anne Pizard; Patrick G Burgon; David L Paul; Benoit G Bruneau; Christine E Seidman; Jonathan G Seidman
Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.
Molecular and cellular biology 2005;25(12):5073-83.
2005: Jost Schönberger; Libin Wang; Jordan T Shin; Sang Do Kim; Frederic F S Depreux; Hao Zhu; Leonard I Zon; Anne Pizard; Jae B Kim; Calum A MacRae; Andrew Mungall; Jonathan G Seidman; Christine E Seidman
Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.
Nature genetics 2005;37(4):418-22.
2005: Hiroyuki Morita; Jonathan Seidman; Christine E Seidman
Genetic causes of human heart failure.
The Journal of clinical investigation 2005;115(3):518-26.
2005: Amy E Roberts; Britta Hult; Heidi L Rehm; Heidi L Rehm; Barbara McDonough; Scott Barr; Christine E Seidman; Jonathan G Seidman; Raju Kucherlapati
The PTPN11 gene is not implicated in nonsyndromic hypertrophic cardiomyopathy.
American journal of medical genetics. Part A 2005;132A(3):333-4.
2005: Michael Arad; Barry J Maron; Joshua M Gorham; Walter H Johnson; J Philip Saul; Antonio R Perez-Atayde; Paolo Spirito; Gregory B Wright; Ronald J Kanter; Christine E Seidman; Jonathan G Seidman
Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
The New England journal of medicine 2005;352(4):362-72.
2004: Bradley M Palmer; Bradley K McConnell; Guo Hua Li; Christine E Seidman; Jonathan G Seidman; Thomas C Irving; Norman R Alpert; David Wayne Maughan
Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C.
Molecular and cellular biochemistry 2004;263(1-2):73-80.
2004: Ivan P G Moskowitz; Anne Pizard; Vickas V Patel; Benoit G Bruneau; Jae B Kim; Sabina Kupershmidt; Dan Mark Roden; Charles I Berul; Christine E Seidman; Jonathan G Seidman
The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Development (Cambridge, England) 2004;131(16):4107-16.
2004: Ivan J Keogh; Ricardo N Godinho; T Po Wu; A M Diaz de Palacios; N Palacios; M Bello de Alford; M I De Almada; N MarPalacios; Ana E Vazquez; R Mattei; Christine E Seidman; J Seidman; Roland D Eavey
Clinical and genetic linkage analysis of a large Venezuelan kindred with Usher syndrome.
International journal of pediatric otorhinolaryngology 2004;68(8):1063-8.
2004: Bradley M Palmer; David E Fishbaugher; Joachim P Schmitt; Yuan Wang; Norman R Alpert; Christine E Seidman; Jonathan G Seidman; Peter VanBuren; David Wayne Maughan
Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H91-9.
2004: Bradley M Palmer; Teruo Noguchi; Yuan Wang; John R Heim; Norman R Alpert; Patrick G Burgon; Christine E Seidman; Jonathan G Seidman; David Wayne Maughan; Martin M LeWinter
Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardium.
Circulation research 2004;94(12):1615-22.
2004: Bradley M Palmer; Dimitrios Georgakopoulos; Paul Janssen; Yuan Wang; Norman R Alpert; Diego F Belardi; Samantha Harris; Richard L Moss; Patrick G Burgon; Christine E Seidman; Jonathan G Seidman; David Wayne Maughan; David A Kass
Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening.
Circulation research 2004;94(9):1249-55.
2004: Dolrudee Jumlongras; Jenn-Yih Lin; Anas Chapra; Christine E Seidman; Jonathan G Seidman; Richard L Maas; Bjorn R Olsen
A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia.
Human genetics 2004;114(3):242-9.
2003: Vickas V Patel; Michael Arad; Ivan P G Moskowitz; Colin T Maguire; Dorothy Branco; Jonathan G Seidman; Christine E Seidman; Charles I Berul
Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Journal of the American College of Cardiology 2003;42(5):942-51.
2003: Joachim P Schmitt; Christopher Semsarian; Michael Arad; Joseph Gannon; Ferhaan Ahmad; Catherine Duffy; Richard T Lee; Christine E Seidman; Jonathan G Seidman
Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy.
Circulation 2003;108(9):1133-8.
2003: Michael Arad; Ivan P G Moskowitz; Vickas V Patel; Ferhaan Ahmad; Antonio R Perez-Atayde; Douglas B Sawyer; Mark Walter; Guo H Li; Patrick G Burgon; Colin T Maguire; David Stapleton; Joachim P Schmitt; X X Guo; Anne Pizard; Sabina Kupershmidt; Dan Mark Roden; Charles I Berul; Christine E Seidman; Jonathan G Seidman
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Circulation 2003;107(22):2850-6.
2003: Joachim P Schmitt; Mitsuhiro Kamisago; Michio Asahi; Guo Hua Li; Ferhaan Ahmad; Ulrike Mende; Evangelia G Kranias; David H MacLennan; Jonathan G Seidman; Christine E Seidman
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.
Science (New York, N.Y.) 2003;299(5611):1410-3.
2002: Michael Arad; Jonathan G Seidman; Christine E Seidman
Phenotypic diversity in hypertrophic cardiomyopathy.
Human molecular genetics 2002;11(20):2499-506.
2002: Carolyn Y Ho; Nancy K Sweitzer; Barbara McDonough; Barry J Maron; Susan A Casey; Jonathan G Seidman; Christine E Seidman; Scott D Solomon
Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy.
Circulation 2002;105(25):2992-7.
2002: Christopher Semsarian; Imran Ahmad; Michael Giewat; Dimitrios Georgakopoulos; Joachim P Schmitt; Bradley K McConnell; Steven Reiken; Ulrike Mende; Andrew R Marks; David A Kass; Christine E Seidman; Jonathan G Seidman
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.
The Journal of clinical investigation 2002;109(8):1013-20.
2002: Jonathan G Seidman; Christine E Seidman
Transcription factor haploinsufficiency: when half a loaf is not enough.
The Journal of clinical investigation 2002;109(4):451-5.
2002: Michael Arad; D Woodrow Benson; Antonio R Perez-Atayde; William J McKenna; Elizabeth A Sparks; Ronald J Kanter; Kate McGarry; Jonathan G Seidman; Christine E Seidman
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
The Journal of clinical investigation 2002;109(3):357-62.
2002: Brenda Gerull; Michael Gramlich; John Atherton; Mark McNabb; Karoly Trombitás; Sabine Sasse-Klaassen; Jonathan G Seidman; Christine E Seidman; Henk Granzier; Siegfried Labeit; Michael Frenneaux; Ludwig Thierfelder
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Nature genetics 2002;30(2):201-4.
2002: Hideshi Niimura; Kristen Patton; William J McKenna; Johann Soults; Barry J Maron; Jonathan G Seidman; Christine E Seidman
Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Circulation 2002;105(4):446-51.
2002: Christine E Seidman; Jonathan G Seidman
The coming of age of cardiovascular science.
Cold Spring Harbor symposia on quantitative biology 2002;67():543-50.
2002: Hiroyuki Morita; Steven R Depalma; Michael Arad; Barbara McDonough; Scott Barr; Catherine Duffy; Barry J Maron; Christine E Seidman; Jonathan G Seidman
Molecular epidemiology of hypertrophic cardiomyopathy.
Cold Spring Harbor symposia on quantitative biology 2002;67():383-8.
2002: Makoto Tanaka; Charles I Berul; M Ishii; Patrick Y Jay; Hiroko Wakimoto; Pamela S Douglas; N Yamasaki; T Kawamoto; Josef Gehrmann; Colin T Maguire; M Schinke; Christine E Seidman; Jonathan G Seidman; Y Kurachi; Seigo Izumo
A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
Cold Spring Harbor symposia on quantitative biology 2002;67():317-25.
2001: Charles I Berul; Bradley K McConnell; Hiroko Wakimoto; Ivan P G Moskowitz; Colin T Maguire; Christopher Semsarian; M M Vargas; Josef Gehrmann; Christine E Seidman; Jonathan G Seidman
Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Circulation 2001;104(22):2734-9.
2001: Christopher Semsarian; M J Healey; D Fatkin; Michael Giewat; Catherine Duffy; Christine E Seidman; Jonathan G Seidman
A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2001;33(11):2055-60.
2001: Benoit G Bruneau; Georges M Nemer; Joachim P Schmitt; Frédéric Charron; Lynda Robitaille; S Caron; David A Conner; M Gessler; Mona Nemer; Christine E Seidman; Jonathan G Seidman
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.
Cell 2001;106(6):709-21.
2001: J Schönberger; Christine E Seidman
Many roads lead to a broken heart: the genetics of dilated cardiomyopathy.
American journal of human genetics 2001;69(2):249-60.
2001: D Jumlongras; Marianna Bei; J M Stimson; W F Wang; S R DePalma; Christine E Seidman; U Felbor; R Maas; Jonathan G Seidman; B R Olsen
A nonsense mutation in MSX1 causes Witkop syndrome.
American journal of human genetics 2001;69(1):67-74.
2001: Bradley K McConnell; D Fatkin; Christopher Semsarian; K A Jones; Dimitrios Georgakopoulos; Colin T Maguire; M J Healey; James OTIS Mudd; Ivan P G Moskowitz; David A Conner; Michael Giewat; Hiroko Wakimoto; Charles I Berul; Frederick J Schoen; David A Kass; Christine E Seidman; Jonathan G Seidman
Comparison of two murine models of familial hypertrophic cardiomyopathy.
Circulation research 2001;88(4):383-9.
2001: Benoit G Bruneau; Zheng-Zheng Bao; D Fatkin; José Xavier-Neto; Dimitrios Georgakopoulos; Colin T Maguire; Charles I Berul; David A Kass; Mercedes L Kuroski de Bold; Adolfo J de Bold; David A Conner; Nadia Rosenthal; Constance L Cepko; Christine E Seidman; Jonathan G Seidman
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Molecular and cellular biology 2001;21(5):1730-6.
2001: Jonathan G Seidman; Christine E Seidman
The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms.
Cell 2001;104(4):557-67.
2001: Christopher Semsarian; Christine E Seidman
Molecular medicine in the 21st century.
Internal medicine journal 2001;31(1):53-9.
2000: M Kamisago; S D Sharma; Steven R Depalma; S Solomon; P Sharma; Barbara McDonough; L Smoot; M P Mullen; P K Woolf; E D Wigle; Jonathan G Seidman; Christine E Seidman
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy.
The New England journal of medicine 2000;343(23):1688-96.
2000: D Fatkin; Bradley K McConnell; James OTIS Mudd; Christopher Semsarian; I G Moskowitz; Frederick J Schoen; Michael Giewat; Christine E Seidman; Jonathan G Seidman
An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.
The Journal of clinical investigation 2000;106(11):1351-9.
2000: Carolyn Y Ho; H M Lever; R DeSanctis; C F Farver; Jonathan G Seidman; Christine E Seidman
Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Circulation 2000;102(16):1950-5.
2000: Hideko Kasahara; B Lee; J J Schott; D Woodrow Benson; Jonathan G Seidman; Christine E Seidman; Seigo Izumo
Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.
The Journal of clinical investigation 2000;106(2):299-308.
2000: Jost Schönberger; Hara Levy; E Grünig; S Sangwatanaroj; D Fatkin; Calum A MacRae; H Stäcker; Chris Halpin; Roland D Eavey; Edward F Philbin; H Katus; Jonathan G Seidman; Christine E Seidman
Dilated cardiomyopathy and sensorineural hearing loss: a heritable syndrome that maps to 6q23-24.
Circulation 2000;101(15):1812-8.
2000: Matthew J Tyska; E Hayes; M Giewat; Christine E Seidman; Jonathan G Seidman; David M Warshaw
Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy.
Circulation research 2000;86(7):737-44.
2000: Howard Yeon; Noralane Lindor; Jonathan G Seidman; Christine E Seidman
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome maps to chromosome 15q.
American journal of human genetics 2000;66(4):1443-8.
2000: Benoit G Bruneau; Zheng-Zheng Bao; M Tanaka; J J Schott; Seigo Izumo; Constance L Cepko; Jonathan G Seidman; Christine E Seidman
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.
Developmental biology 2000;217(2):266-77.
2000: Roland D Eavey; EN Manolis; J Lubianca; S Merchant; Jonathan G Seidman; Christine E Seidman
Mutations in COCH (formerly Coch5b2) cause DFNA9.
Advances in oto-rhino-laryngology 2000;56():101-2.
1999: D Fatkin; Calum A MacRae; T Sasaki; M R Wolff; M Porcu; Michael Frenneaux; John Atherton; H J Vidaillet; S Spudich; Umberto De Girolami; Jonathan G Seidman; Christine E Seidman; F Muntoni; G Müehle; W Johnson; B McDonough
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease.
The New England journal of medicine 1999;341(23):1715-24.
1999: Bradley K McConnell; K A Jones; D Fatkin; L H Arroyo; R T Lee; Orlando Aristizabal; Daniel Turnbull; Dimitrios Georgakopoulos; David A Kass; Meredith Bond; Hideshi Niimura; Frederick J Schoen; David A Conner; D A Fischman; Christine E Seidman; Jonathan G Seidman; D H Fischman
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice.
The Journal of clinical investigation 1999;104(9):1235-44.
1999: EN Manolis; Roland D Eavey; S Sangwatanaroj; Chris Halpin; S Rosenbaum; H Watkins; J Jarcho; Christine E Seidman; Jonathan G Seidman
Hereditary postlingual sensorineural hearing loss mapping to chromosome Xq21.
The American journal of otology 1999;20(5):621-6.
1999: Benoit G Bruneau; Malcolm Logan; N Davis; T Levi; Clifford J Tabin; Jonathan G Seidman; Christine E Seidman
Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.
Developmental biology 1999;211(1):100-8.
1999: E J Gruver; D Fatkin; G A Dodds; J Kisslo; B J Maron; Jonathan G Seidman; Christine E Seidman
Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.
The American journal of cardiology 1999;83(12A):13H-18H.
1999: AA Mehdirad; D Fatkin; J P DiMarco; Calum A MacRae; Abdul Wase; Jonathan G Seidman; Christine E Seidman; D Woodrow Benson
Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome.
Journal of cardiovascular electrophysiology 1999;10(5):629-35.
1999: Laura M Bevilacqua; Colin T Maguire; Jonathan G Seidman; Christine E Seidman; Charles I Berul
QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice.
Pediatric research 1999;45(5 Pt 1):643-7.
1999: E Blanchard; Christine E Seidman; Jonathan G Seidman; Martin M LeWinter; David Wayne Maughan
Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Circulation research 1999;84(4):475-83.
1999: B L Siu; Hideshi Niimura; J A Osborne; D Fatkin; Calum A MacRae; S Solomon; D Woodrow Benson; Jonathan G Seidman; Christine E Seidman
Familial dilated cardiomyopathy locus maps to chromosome 2q31.
Circulation 1999;99(8):1022-6.
1999: Zheng-Zheng Bao; Benoit G Bruneau; Jonathan G Seidman; Christine E Seidman; Constance L Cepko
Regulation of chamber-specific gene expression in the developing heart by Irx4.
Science (New York, N.Y.) 1999;283(5405):1161-4.
1999: D Fatkin; Michael Christe; Orlando Aristizabal; Bradley K McConnell; S Srinivasan; Frederick J Schoen; Christine E Seidman; Daniel Turnbull; Jonathan G Seidman
Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.
The Journal of clinical investigation 1999;103(1):147-53.
1998: Nahid G Robertson; L Lu; Stefan Heller; Saumil N Merchant; Roland D Eavey; M McKenna; Joseph B Nadol; R T Miyamoto; F H Linthicum; JF Lubianca Neto; A J Hudspeth; Christine E Seidman; Cynthia C Morton; Jonathan G Seidman
Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction.
Nature genetics 1998;20(3):299-303.
1998: J J Schott; D Woodrow Benson; Craig T Basson; W Pease; Gary M Silberbach; J P Moak; B J Maron; Christine E Seidman; Jonathan G Seidman
Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Science (New York, N.Y.) 1998;281(5373):108-11.
1998: CS Kovacs; C L Ho-Pao; Joy Hunzelman; Beate Lanske; J Fox; Jonathan G Seidman; Christine E Seidman; Henry M Kronenberg
Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor.
The Journal of clinical investigation 1998;101(12):2812-20.
1998: D Woodrow Benson; A Sharkey; D Fatkin; P Lang; Craig T Basson; B McDonough; A W Strauss; Jonathan G Seidman; Christine E Seidman
Reduced penetrance, variable expressivity, and genetic heterogeneity of familial atrial septal defects.
Circulation 1998;97(20):2043-8.
1998: JF Lubianca Neto; L Lu; Roland D Eavey; M A Flores; R M Caldera; S Sangwatanaroj; J J Schott; Barbara McDonough; J I Santos; Christine E Seidman; Jonathan G Seidman
The Bjornstad syndrome (sensorineural hearing loss and pili torti) disease gene maps to chromosome 2q34-36.
American journal of human genetics 1998;62(5):1107-12.
1998: Hideshi Niimura; L L Bachinski; S Sangwatanaroj; H Watkins; A E Chudley; W McKenna; A Kristinsson; R Roberts; M Sole; Barry J Maron; Jonathan G Seidman; Christine E Seidman
Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy.
The New England journal of medicine 1998;338(18):1248-57.
1998: Matthias Spindler; Kurt W Saupe; Michael Christe; H L Sweeney; Christine E Seidman; Jonathan G Seidman; Joanne S Ingwall
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
The Journal of clinical investigation 1998;101(8):1775-83.
1998: Charles I Berul; M E Christe; Mark Aronovitz; Colin T Maguire; Christine E Seidman; Jonathan G Seidman; Michael Mendelsohn
Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 1998;2(1):7-14.
1998: Christine E Seidman; Jonathan G Seidman
Molecular genetic studies of familial hypertrophic cardiomyopathy.
Basic research in cardiology 1998;93 Suppl 3():13-6.
1997: D A Conner; M A Mathier; richard mortensen; Michael Christe; S F Vatner; Christine E Seidman; Jonathan G Seidman
beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation.
Circulation research 1997;81(6):1021-6.
1997: E M Blanchard; K Iizuka; Michael Christe; D A Conner; A Geisterfer-Lowrance; Frederick J Schoen; David Wayne Maughan; Christine E Seidman; Jonathan G Seidman
Targeted ablation of the murine alpha-tropomyosin gene.
Circulation research 1997;81(6):1005-10.
1997: C L Shovlin; J M Hughes; J Scott; Christine E Seidman; Jonathan G Seidman
Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia.
American journal of human genetics 1997;61(1):68-79.
1997: DA Coviello; Barry J Maron; P Spirito; H Watkins; H P Vosberg; Ludwig Thierfelder; Frederick J Schoen; Jonathan G Seidman; Christine E Seidman
Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.
Journal of the American College of Cardiology 1997;29(3):635-40.
1997: Charles I Berul; M E Christe; Mark Aronovitz; Christine E Seidman; Jonathan G Seidman; Michael Mendelsohn
Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
The Journal of clinical investigation 1997;99(4):570-6.
1997: Craig T Basson; David Bachinsky; R C Lin; T Levi; J A Elkins; J Soults; D Grayzel; E Kroumpouzou; THOMAS TRAILL; J Leblanc-Straceski; B Renault; R Kucherlapati; Jonathan G Seidman; Christine E Seidman
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.
Nature genetics 1997;15(1):30-5.
1996: J A Encinas; Marjorie B Lees; Raymond A Sobel; C Symonowicz; Judith Greer; C L Shovlin; Howard L Weiner; Christine E Seidman; Jonathan G Seidman; Vijay K Kuchroo
Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2186-92.
1996: Craig T Basson; Calum A MacRae; M Schoenberg-Fejzo; Cynthia C Morton; Nancy B Spinner; Anna Genin; E Krug; Jonathan G Seidman; Christine E Seidman
Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130.
Genomics 1996;35(3):628-31.
1996: H Vastardis; N Karimbux; S W Guthua; Jonathan G Seidman; Christine E Seidman
A human MSX1 homeodomain missense mutation causes selective tooth agenesis.
Nature genetics 1996;13(4):417-21.
1996: E N Manolis; N Yandavi; Joseph B Nadol; Roland D Eavey; M McKenna; S Rosenbaum; U Khetarpal; Chris Halpin; Saumil N Merchant; G M Duyk; C MacRae; Christine E Seidman; Jonathan G Seidman
A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13.
Human molecular genetics 1996;5(7):1047-50.
1996: D Woodrow Benson; Calum A MacRae; Mark R Vesely; Edward P Walsh; Jonathan G Seidman; Christine E Seidman; Carol Satler
Missense mutation in the pore region of HERG causes familial long QT syndrome.
Circulation 1996;93(10):1791-5.
1996: A A Geisterfer-Lowrance; Michael Christe; D A Conner; Joanne S Ingwall; Frederick J Schoen; Christine E Seidman; Jonathan G Seidman
A mouse model of familial hypertrophic cardiomyopathy.
Science (New York, N.Y.) 1996;272(5262):731-4.
1996: M R Pollak; Christine E Seidman; Edward M Brown
Three inherited disorders of calcium sensing.
Medicine 1996;75(3):115-23.
1996: B W Zhang; G Zimmer; J Chen; D Ladd; E Li; F W Alt; GJ Wiederrecht; JG Cryan; E A O'Neill; Christine E Seidman; Abul K Abbas; Jonathan G Seidman
T cell responses in calcineurin A alpha-deficient mice.
The Journal of experimental medicine 1996;183(2):413-20.
1996: Stella Mitrani-Rosenbaum; Zohar Argov; A Blumenfeld; Christine E Seidman; Jonathan G Seidman
Hereditary inclusion body myopathy maps to chromosome 9p1-q1.
Human molecular genetics 1996;5(1):159-163.
1995: B A Hendrickson; D A Conner; D J Ladd; D Kendall; J E Casanova; B Corthesy; Edward E Max; Marian R Neutra; Christine E Seidman; Jonathan G Seidman
Altered hepatic transport of immunoglobulin A in mice lacking the J chain.
The Journal of experimental medicine 1995;182(6):1905-11.
1995: H Watkins; D Conner; L Thierfelder; J A Jarcho; Calum A MacRae; W J McKenna; Barry J Maron; Jonathan G Seidman; Christine E Seidman
Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy.
Nature genetics 1995;11(4):434-7.
1995: C Ho; D A Conner; M R Pollak; D J Ladd; Olga Kifor; H B Warren; Edward M Brown; Jonathan G Seidman; Christine E Seidman
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Nature genetics 1995;11(4):389-94.
1995: Edward M Brown; M Pollak; Y H Chou; Christine E Seidman; Jonathan G Seidman; S C Hebert
Cloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney.
Bone 1995;17(2 Suppl):7S-11S.
1995: Edward M Brown; M Pollak; Christine E Seidman; Jonathan G Seidman; Y H Chou; D Riccardi; S C Hebert
Calcium-ion-sensing cell-surface receptors.
The New England journal of medicine 1995;333(4):234-40.
1995: Edward M Brown; M Pollak; Y H Chou; Christine E Seidman; Jonathan G Seidman; S C Hebert
The cloning of extracellular Ca(2+)-sensing receptors from parathyroid and kidney: molecular mechanisms of extracellular Ca(2+)-sensing.
The Journal of nutrition 1995;125(7 Suppl):1965S-1970S.
1995: V Marigo; D J Roberts; S M Lee; O Tsukurov; T Levi; Julie M Gastier-Foster; D J Epstein; D J Gilbert; N G Copeland; Christine E Seidman
Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.
Genomics 1995;28(1):44-51.
1995: H Watkins; R Anan; D A Coviello; P Spirito; Jonathan G Seidman; Christine E Seidman
A de novo mutation in alpha-tropomyosin that causes hypertrophic cardiomyopathy.
Circulation 1995;91(9):2302-5.
1995: H Watkins; Jonathan G Seidman; Christine E Seidman
Familial hypertrophic cardiomyopathy: a genetic model of cardiac hypertrophy.
Human molecular genetics 1995;4 Spec No():1721-7.
1994: H Watkins; Calum A MacRae; D A Fischman; Jonathan G Seidman; Christine E Seidman
A dinucleotide repeat polymorphism in the MYBPH gene.
Human molecular genetics 1994;3(12):2267.
1994: M R Pollak; Edward M Brown; H L Estep; P N McLaine; Olga Kifor; J Park; S C Hebert; Christine E Seidman; Jonathan G Seidman
Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation.
Nature genetics 1994;8(3):303-7.
1994: G Greve; Linda L Bachinski; D L Friedman; G Czernuzewicz; R Anan; Jeffrey A Towbin; Christine E Seidman; Robert Roberts
Isolation of a de novo mutant myocardial beta MHC protein in a pedigree with hypertrophic cardiomyopathy.
Human molecular genetics 1994;3(11):2073-5.
1994: L Thierfelder; H Watkins; Calum A MacRae; R Lamas; W McKenna; H P Vosberg; Jonathan G Seidman; Christine E Seidman
Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.
Cell 1994;77(5):701-12.
1994: Craig T Basson; G S Cowley; Scott D Solomon; B Weissman; A K Poznanski; THOMAS TRAILL; Jonathan G Seidman; Christine E Seidman
The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome)
The New England journal of medicine 1994;330(13):885-91.
1994: A J Straceski; A Geisterfer-Lowrance; Christine E Seidman; Jonathan G Seidman; Leslie A Leinwand
Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):589-93.
1994: Calum A MacRae; H C Watkins; J A Jarcho; L Thierfelder; W J McKenna; Jonathan G Seidman; Christine E Seidman
An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations.
Circulation 1994;89(1):33-5.
1993: M R Pollak; Edward M Brown; Y H Chou; S C Hebert; S J Marx; B Steinmann; T Levi; Christine E Seidman; Jonathan G Seidman
Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Cell 1993;75(7):1297-303.
1993: H Watkins; L Thierfelder; R Anan; J Jarcho; A Matsumori; W McKenna; Jonathan G Seidman; Christine E Seidman
Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy.
American journal of human genetics 1993;53(6):1180-5.
1993: M R Pollak; Y H Chou; J J Cerda; B Steinmann; B N La Du; Jonathan G Seidman; Christine E Seidman
Homozygosity mapping of the gene for alkaptonuria to chromosome 3q2.
Nature genetics 1993;5(2):201-4.
1993: Scott D Solomon; S Wolff; H Watkins; Paul M Ridker; PC Come; W J McKenna; Christine E Seidman; Richard T Lee
Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene.
Journal of the American College of Cardiology 1993;22(2):498-505.
1993: H C Watkins; Calum A MacRae; L Thierfelder; W J McKenna; Christine E Seidman; Jonathan G Seidman
A dinucleotide repeat polymorphism in the human LAMB2 gene on chromosome 1q.
Human molecular genetics 1993;2(7):1084.
1993: H Watkins; Calum A MacRae; L Thierfelder; Y H Chou; M Frenneaux; W McKenna; Jonathan G Seidman; Christine E Seidman
A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3.
Nature genetics 1993;3(4):333-7.
1992: H Watkins; L Thierfelder; D S Hwang; W McKenna; Jonathan G Seidman; Christine E Seidman
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
The Journal of clinical investigation 1992;90(5):1666-71.
1992: Y H Chou; E M Brown; T Levi; G Crowe; A B Atkinson; H J Arnqvist; Göran Toss; G E Fuleihan; Jonathan G Seidman; Christine E Seidman
The gene responsible for familial hypocalciuric hypercalcemia maps to chromosome 3q in four unrelated families.
Nature genetics 1992;1(4):295-300.
1992: H Watkins; A Rosenzweig; D S Hwang; T Levi; W McKenna; Christine E Seidman; Jonathan G Seidman
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.
The New England journal of medicine 1992;326(17):1108-14.
1992: H Watkins; Christine E Seidman; Calum A MacRae; Jonathan G Seidman; W McKenna
Progress in familial hypertrophic cardiomyopathy: molecular genetic analyses in the original family studied by Teare.
British heart journal 1992;67(1):34-8.
1991: A Rosenzweig; H Watkins; D S Hwang; M Miri; W McKenna; THOMAS TRAILL; Jonathan G Seidman; Christine E Seidman
Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes.
The New England journal of medicine 1991;325(25):1753-60.
1991: Christine E Seidman; E V Schmidt; Jonathan G Seidman
cis-dominance of rat atrial natriuretic factor gene regulatory sequences in transgenic mice.
Canadian journal of physiology and pharmacology 1991;69(10):1486-92.
1991: A Rosenzweig; Thanos D Halazonetis; Jonathan G Seidman; Christine E Seidman
Proximal regulatory domains of rat atrial natriuretic factor gene.
Circulation 1991;84(3):1256-65.
1991: Christine E Seidman; Jonathan G Seidman
Mutations in cardiac myosin heavy chain genes cause familial hypertrophic cardiomyopathy.
Molecular biology & medicine 1991;8(2):159-66.
1991: A Rosenzweig; Christine E Seidman
Atrial natriuretic factor and related peptide hormones.
Annual review of biochemistry 1991;60():229-55.
1990: G Tanigawa; J A Jarcho; S Kass; Scott D Solomon; H P Vosberg; Jonathan G Seidman; Christine E Seidman
A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene.
Cell 1990;62(5):991-8.
1990: A A Geisterfer-Lowrance; S Kass; G Tanigawa; H P Vosberg; W McKenna; Christine E Seidman; Jonathan G Seidman
A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation.
Cell 1990;62(5):999-1006.
1990: Scott D Solomon; J A Jarcho; W McKenna; A Geisterfer-Lowrance; R Germain; R Salerni; Jonathan G Seidman; Christine E Seidman
Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.
The Journal of clinical investigation 1990;86(3):993-9.
1990: Nicholas Izzo; Christine E Seidman; S Collins; Wilson S Colucci
Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6268-71.
1989: J A Jarcho; W McKenna; J A Pare; Scott D Solomon; R F Holcombe; S Dickie; T Levi; H Donis-Keller; Jonathan G Seidman; Christine E Seidman
Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1.
The New England journal of medicine 1989;321(20):1372-8.
1988: Christine E Seidman; D W Wong; J A Jarcho; Kenneth D Bloch; Jonathan G Seidman
Cis-acting sequences that modulate atrial natriuretic factor gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):4104-8.
1988: Richard T Lee; Kenneth D Bloch; J M Pfeffer; M A Pfeffer; E J Neer; Christine E Seidman
Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy.
The Journal of clinical investigation 1988;81(2):431-4.