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Mark Seielstad

Research Profile

Genes & Molecular Sequences

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Asian Continental Ancestry Group

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TOP 3
Eileen Png; Edhyana Sahiratmadja; Reinout van Crevel; Esther van de Vosse; Iskandar Adnan; Alisjahbana Bachti; Martin Hibberd; Sangkot Marzuki; Ron Nelwan; Tom H M Ottenhoff; Mark Seielstad
Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.
Tom H M Ottenhoff; Edhyana Sahiratmadja; Mark Seielstad; Reinout van Crevel; Esther van de Vosse; Hazel E E Wong; Ninghan Yang; Mingzi M Zhang; Alisjahbana Bachti; Ranjeeta Hari Dass; Chiea Chuen Khor; Sangkot Marzuki; Martin L Hibberd
Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.
Qiao Fan; Liang-Kee Goh; Felicia Hawthorne; Candice E H Ho; Hidetoshi Inoko; Chiea C Khor; Yi-Ju Li; Wan'e Lim; Fumihiko Matsuda; Keitaro Matsuo; Akira Meguro; Nobuhisa Mizuki; Isao Nakata; Kyoko Ohno-Matsui; Mark Seielstad; E Shyong Tai; Yik-Ying Teo; Eranga N Vithana; Tien Yin Wong; Kenji Yamashiro; Nagahisa Yoshimura; Terri L Young; Yingfeng Zheng; Xin Zhou; Tin Aung; Veluchamy A Barathi; Roger W Beuerman; Ching-Yu Cheng; Daniel Chua; Seang-Mei Saw
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.

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All Publications

2012: Eileen Png; Edhyana Sahiratmadja; Reinout van Crevel; Esther van de Vosse; Iskandar Adnan; Alisjahbana Bachti; Martin Hibberd; Sangkot Marzuki; Ron Nelwan; Tom H M Ottenhoff; Mark Seielstad
Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2012;12(6):1319-23.
2012: Tom H M Ottenhoff; Edhyana Sahiratmadja; Mark Seielstad; Reinout van Crevel; Esther van de Vosse; Hazel E E Wong; Ninghan Yang; Mingzi M Zhang; Alisjahbana Bachti; Ranjeeta Hari Dass; Chiea Chuen Khor; Sangkot Marzuki; Martin L Hibberd
Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.
PloS one 2012;7(9):e45839.
2012: Qiao Fan; Liang-Kee Goh; Felicia Hawthorne; Candice E H Ho; Hidetoshi Inoko; Chiea C Khor; Yi-Ju Li; Wan'e Lim; Fumihiko Matsuda; Keitaro Matsuo; Akira Meguro; Nobuhisa Mizuki; Isao Nakata; Kyoko Ohno-Matsui; Mark Seielstad; E Shyong Tai; Yik-Ying Teo; Eranga N Vithana; Tien Yin Wong; Kenji Yamashiro; Nagahisa Yoshimura; Terri L Young; Yingfeng Zheng; Xin Zhou; Tin Aung; Veluchamy A Barathi; Roger W Beuerman; Ching-Yu Cheng; Daniel Chua; Seang-Mei Saw
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.
PLoS genetics 2012;8(6):e1002753.
2012: Eileen Png; Edhyana Sahiratmadja; Reinout van Crevel; Esther van de Vosse; Iskandar Adnan; Alisjahbana Bachti; Yanina Balabanova; Francis Drobniewski; Martin L Hibberd; Sangkot Marzuki; Sergey Nejentsev; Ron Nelwan; Vladyslav Nikolayevskyy; Tom H M Ottenhoff; Mark Seielstad
A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.
BMC medical genetics 2012;13():5.
2011: Qiao Fan; Liang-Kee Goh; Mohammad Kamran Ikram; Chiea C Khor; Yi-Ju Li; Jianjun Liu; Rick Twee-Hee Ong; Mark Seielstad; Xueling Sim; Chen Suo; E Shyong Tai; Wan-Ting Tay; Yik-Ying Teo; Eranga N Vithana; Tien Yin Wong; Terri L Young; Xin Zhou; Tin Aung; Ching-Yu Cheng; Kee-Seng Chia; Belinda Cornes; Seang-Mei Saw
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
PLoS genetics 2011;7(12):e1002402.
2011: Haiyan Xu; Tien Yin Wong; Tin Aung; Kee-Seng Chia; Chiea C Khor; Jianjun Liu; Rick Twee-Hee Ong; Wan-Ting Poh; Mark Seielstad; Xueling Sim; Chen Suo; E Shyong Tai; Wan-Ting Tay; Yik-Ying Teo
SgD-CNV, a database for common and rare copy number variants in three Asian populations.
Human mutation 2011;32(12):1341-9.
2011: Eileen Png; Greet J Boland; Rick T H Ong; Harm Snippe; Anbupalam Thalamuthu; Mark Seielstad
A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.
Human molecular genetics 2011;20(19):3893-8.
2011: Siyu Han; Chiea-Chuen Khor; Raghavan Lavanya; Jeannette Jen-Mai Lee; Jianjun Liu; Rick Twee-Hee Ong; Tin Aung; Peng Chen; Kee-Seng Chia; Qiao Fan; Liang-Kee Goh; Mark Seielstad; Xueling Sim; Chen Suo; E Shyong Tai; Wan-Ting Tay; Yik-Ying Teo; Eranga N Vithana; Tien Yin Wong; Renyi Wu; Yingfeng Zheng; Seang-Mei Saw
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
Human molecular genetics 2011;20(18):3693-8.
2011: Chee-Seng Ku; Nasheen Naidoo; Yudi Pawitan; Mark Seielstad; Xueling Sim; Shu-Mei Teo; Yik-Ying Teo; Kee-Seng Chia; Agus Salim
Copy number polymorphisms in new HapMap III and Singapore populations.
Journal of human genetics 2011;56(8):552-60.
2011: Shu Mei Teo; Yudi Pawitan; Vikrant Kumar; Anbupalam Thalamuthu; Mark Seielstad; Kee-Seng Chia; Agus Salim
Multi-platform segmentation for joint detection of copy number variants.
Bioinformatics (Oxford, England) 2011;27(11):1555-61.
2011: Chiea Chuen Khor; Wishal D Ramdas; Eranga N Vithana; Belinda K Cornes; Xueling Sim; Wan-Ting Tay; Seang-Mei Saw; Yingfeng Zheng; Raghavan Lavanya; Renyi Wu; Jie Jin Wang; Paul Mitchell; André G Uitterlinden; Fernando Rivadeneira; Yik-Ying Teo; Kee-Seng Chia; Mark Seielstad; Martin Hibberd; Johannes Vingerling; Caroline C W Klaver; Nomdo M Jansonius; E Shyong Tai; Tien Yin Wong; Cornelia M van Duijn; Tin Aung
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
Human molecular genetics 2011;20(9):1864-72.
2011: Xueling Sim; Rick Twee-Hee Ong; Chen Suo; Wan-Ting Tay; Jianjun Liu; Daniel P K Ng; Michael Boehnke; Kee-Seng Chia; Tien Yin Wong; Mark Seielstad; Yik-Ying Teo; E Shyong Tai
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
PLoS genetics 2011;7(4):e1001363.
2011: Eranga N Vithana; Tin Aung; Chiea Chuen Khor; Belinda K Cornes; Wan-Ting Tay; Xueling Sim; Raghavan Lavanya; Renyi Wu; Yingfeng Zheng; Martin L Hibberd; Kee-Seng Chia; Mark Seielstad; Liang Kee Goh; Seang-Mei Saw; E Shyong Tai; Tien Y Wong
Collagen-related genes influence the glaucoma risk factor, central corneal thickness.
Human molecular genetics 2011;20(4):649-58.
2011: Leonid Padyukov; Mark Seielstad; Rick T H Ong; Bo Ding; Johan Rönnelid; Maria Seddighzadeh; Lars Alfredsson; Lars Klareskog
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Annals of the rheumatic diseases 2011;70(2):259-65.
2011: Wibhu Kutanan; Jatupol Kampuansai; Vincenza Colonna; Supaporn Nakbunlung; Pornpilai Lertvicha; Mark Seielstad; Giorgio Bertorelle; Daoroong Kangwanpong
Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci.
Journal of human genetics 2011;56(2):130-7.
2011: Yi-Ju Li; Liang Goh; Chiea-Chuen Khor; Qiao Fan; Miao Yu; Siyu Han; Xueling Sim; Rick Twee-Hee Ong; Tien Yin Wong; Eranga Nishanthie Vithana; Eric Yap; Hideo Nakanishi; Fumihiko Matsuda; Kyoko Ohno-Matsui; Nagahisa Yoshimura; Mark Seielstad; E Shyong Tai; Terri L Young; Seang-Mei Saw
Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.
Ophthalmology 2011;118(2):368-75.
2011: Wibhu Kutanan; Supaporn Nakbunlung; Mark Seielstad; Giorgio Bertorelle; Silvia Fuselli; Jatupol Kampuansai; Daoroong Kangwanpong
Genetic structure of the Mon-Khmer speaking groups and their affinity to the neighbouring Tai populations in Northern Thailand.
BMC genetics 2011;12():56.
2011: Jingyuan Zhao; Simone Gupta; Mark Seielstad; Jianjun Liu; Anbupalam Thalamuthu
Pathway-based analysis using reduced gene subsets in genome-wide association studies.
BMC bioinformatics 2011;12():17.
2010: Xiao-Ou Shu; Jirong Long; Qiuyin Cai; Lu Qi; Yong-Bing Xiang; Yoon Shin Cho; E Shyong Tai; Xiangyang Li; Xu Lin; Wong-Ho Chow; Min Jin Go; Mark Seielstad; Wei Bao; Huaixing Li; Marilyn C Cornelis; Kai Yu; Wanqing Wen; Jiajun Shi; Bok Ghee Han; Xue Ling Sim; Liegang Liu; Qibin Qi; Hyung-Lae Kim; Daniel P K Ng; Jong-Young Lee; Young Jin Kim; Chun Li; Yu-Tang Gao; Wei Zheng; Frank B Hu
Identification of new genetic risk variants for type 2 diabetes.
PLoS genetics 2010;6(9):.
2010: Chiea C Khor; Qiao Fan; Liang Goh; Donald Tan; Terri L Young; Yi-Ju Li; Mark Seielstad; Denise L M Goh; Seang-Mei Saw
Support for TGFB1 as a susceptibility gene for high myopia in individuals of Chinese descent.
Archives of ophthalmology 2010;128(8):1081-4.
2010: Chee-Seng Ku; Yudi Pawitan; Xueling Sim; Rick T H Ong; Mark Seielstad; Edmund J D Lee; Yik-Ying Teo; Kee-Seng Chia; Agus Salim
Genomic copy number variations in three Southeast Asian populations.
Human mutation 2010;31(7):851-7.
2010: Leif Törkvist; Jonas Halfvarson; Rick T H Ong; Mikael Lördal; Urban Sjöqvist; Francesca Bresso; Jan Björk; Ragnar Befrits; Robert Löfberg; Johannes Blom; Marie Carlson; Leonid Padyukov; Mauro D'Amato; Mark Seielstad; Sven Pettersson
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
Inflammatory bowel diseases 2010;16(6):907-9.
2010: Andrew E Dellinger; Seang-Mei Saw; Liang K Goh; Mark Seielstad; Terri L Young; Yi-Ju Li
Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays.
Nucleic acids research 2010;38(9):e105.
2010: Chiea C Khor; Qiao Fan; Liang-Kee Goh; Tien Y Wong; Yi-Ju Li; Ning Cheung; Mark Seielstad; Denise L M Goh; Terri L Young; E Shyong Tai; Seang-Mei Saw
Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese.
Ophthalmology 2010;117(5):939-45.
2010: Jonathan T Tan; Daniel P K Ng; Siti Nurbaya; Sandra Ye; Xiu Li Lim; Helen Leong; Lin Tze Seet; Wei Fong Siew; Winston Kon; Tien Yin Wong; Seang-Mei Saw; Tin Aung; Kee-Seng Chia; Jeannette Lee; Suok Kai Chew; Mark Seielstad; E Shyong Tai
Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.
The Journal of clinical endocrinology and metabolism 2010;95(1):390-7.
2009: Jieming Chen; Houfeng Zheng; Jin-Xin Bei; Liangdan Sun; Wei-hua Jia; Tao Li; Furen Zhang; Mark Seielstad; Yi-Xin Zeng; Xuejun Zhang; Jianjun Liu
Genetic structure of the Han Chinese population revealed by genome-wide SNP variation.
American journal of human genetics 2009;85(6):775-85.
2009: Yik-Ying Teo; Xueling Sim; Rick T H Ong; Adrian K S Tan; Jieming Chen; Erwin Tantoso; Kerrin S Small; Chee-Seng Ku; Edmund J D Lee; Mark Seielstad; Kee-Seng Chia
Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations.
Genome research 2009;19(11):2154-62.
2009: Laurence S Lim; E Shyong Tai; Tin Aung; Wan Ting Tay; Seang-Mei Saw; Mark Seielstad; Tien Yin Wong
Relation of age-related cataract with obesity and obesity genes in an Asian population.
American journal of epidemiology 2009;169(10):1267-74.
2009: Yvonne C Lee; Soumya Raychaudhuri; Jing Cui; Immaculata DeVivo; Bo Ding; Lars Alfredsson; Leonid Padyukov; Karen H Costenbader; Mark Seielstad; Robert R Graham; Lars Klareskog; Peter K Gregersen; Robert M Plenge; Elizabeth W Karlson
The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
Arthritis and rheumatism 2009;60(5):1250-4.
2009: E Shyong Tai; Xue Ling Sim; Twee Hee Ong; Tien Yin Wong; Seang-Mei Saw; Tin Aung; Sekar Kathiresan; Marju Orho-Melander; Jose Ordovas; Jonathan T Tan; Mark Seielstad
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
Journal of lipid research 2009;50(3):514-20.
2009: Huijia Chen; Terry K L Toh; Ildiko Szeverenyi; Rick T H Ong; Colin T S Theng; W H Irwin McLean; Mark Seielstad; E Birgitte Lane
Association of skin barrier genes within the PSORS4 locus is enriched in Singaporean Chinese with early-onset psoriasis.
The Journal of investigative dermatology 2009;129(3):606-14.
2009: Bo Ding; Leonid Padyukov; Emeli Lundström; Mark Seielstad; Robert M Plenge; Jorge R Oksenberg; Peter K Gregersen; Lars Alfredsson; Lars Klareskog
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
Arthritis and rheumatism 2009;60(1):30-8.
2008: N T T Thuong; Sarah J Dunstan; Tran Thi Hong Chau; Vesteinn Thorsson; Cameron P Simmons; Nguyen Than Ha Quyen; Guy E Thwaites; Nguyen Thi Ngoc Lan; Martin Hibberd; Yik Y Teo; Mark Seielstad; Alan Aderem; Jeremy J Farrar; Thomas R Hawn
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.
PLoS pathogens 2008;4(12):e1000229.
2008: Sonia Davila; Martin L Hibberd; Ranjeeta Hari Dass; Hazel E E Wong; Edhyana Sahiratmadja; Carine Bonnard; Alisjahbana Bachti; Jeffrey S Szeszko; Yanina Balabanova; Francis Drobniewski; Reinout van Crevel; Esther van de Vosse; Sergey Nejentsev; Tom H M Ottenhoff; Mark Seielstad
Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.
PLoS genetics 2008;4(10):e1000218.
2008: Jonathan T Tan; Rajkumar Dorajoo; Mark Seielstad; Xue Ling Sim; Rick Twee-Hee Ong; Kee-Seng Chia; Tien Yin Wong; Seang-Mei Saw; Suok Kai Chew; Tin Aung; E Shyong Tai
FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
Diabetes 2008;57(10):2851-7.
2008: Yik Y Teo; Michael Inouye; Kerrin S Small; Andrew E Fry; Simon C Potter; Sarah J Dunstan; Mark Seielstad; Inês Barroso; Nicholas J Wareham; Kirk A Rockett; Dominic P Kwiatkowski; Panos Deloukas
Whole genome-amplified DNA: insights and imputation.
Nature methods 2008;5(4):279-80.
2008: Sergey Nejentsev; Thorsten Thye; Jeffrey S Szeszko; Helen Stevens; Yanina Balabanova; Amanua M Chinbuah; Martin Hibberd; Esther van de Vosse; Alisjahbana Bachti; Reinout van Crevel; Tom H M Ottenhoff; Eileen Png; Francis Drobniewski; John A Todd; Mark Seielstad; Rolf D Horstmann
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
Nature genetics 2008;40(3):261-2; author reply 262-3.
2007: Robert M Plenge; Mark Seielstad; Leonid Padyukov; Annette T Lee; Elaine F Remmers; Bo Ding; Anthony Liew; Houman Khalili; Alamelu Chandrasekaran; Leela R L Davies; Wentian Li; Adrian K S Tan; Carine Bonnard; Rick T H Ong; Anbupalam Thalamuthu; Sven Pettersson; Chunyu Liu; Chao Tian; Wei V Chen; John P Carulli; Evan M Beckman; David Altshuler; Lars Alfredsson; Lindsey A Criswell; Christopher I Amos; Michael F Seldin; Daniel Kastner; Lars Klareskog; Peter K Gregersen
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
The New England journal of medicine 2007;357(12):1199-209.
2007: Yik Y Teo; Andrew E Fry; Taane G Clark; E S Tai; Mark Seielstad
On the usage of HWE for identifying genotyping errors.
Annals of human genetics 2007;71(Pt 5):701-3; author reply 704.
2007: Davide Besaggio; Silvia Fuselli; Metawee Srikummool; Jatupol Kampuansai; Loredana Castrì; Chris Tyler-Smith; Mark Seielstad; Daoroong Kangwanpong; Giorgio Bertorelle
Genetic variation in Northern Thailand Hill Tribes: origins and relationships with social structure and linguistic differences.
BMC evolutionary biology 2007;7 Suppl 2():S12.
2007: Mark Seielstad
HIV, stigma, and rates of infection: absence of evidence.
PLoS medicine 2007;4(1):e54; author reply e44.
2006: Chun Zhang; Dione K Bailey; Tarif Awad; Guoying Liu; Guoliang Xing; Manqiu Cao; Venu Valmeekam; Jacques Retief; Hajime Matsuzaki; Margaret Taub; Mark Seielstad; Giulia C Kennedy
A whole genome long-range haplotype (WGLRH) test for detecting imprints of positive selection in human populations.
Bioinformatics (Oxford, England) 2006;22(17):2122-8.
2003: Mark Seielstad; Nadira Yuldasheva; Nadia Singh; Peter A Underhill; Peter Oefner; Peidong Shen; R Spencer Wells
A novel Y-chromosome variant puts an upper limit on the timing of first entry into the Americas.
American journal of human genetics 2003;73(3):700-5.
2002: Kristin G Ardlie; Kathryn L Lunetta; Mark Seielstad
Testing for population subdivision and association in four case-control studies.
American journal of human genetics 2002;71(2):304-11.
2002: Kristin G Ardlie; Leonid Kruglyak; Mark Seielstad
Patterns of linkage disequilibrium in the human genome.
Nature reviews. Genetics 2002;3(4):299-309.
2001: T Niu; Mark Seielstad; X Zeng; A Apffel; G Li; KM Hahnenberger; X Xu
Detection of novel ALAD gene polymorphisms using denaturing high-performance liquid chromatography.
Human biology 2001;73(3):429-42.
2001: Y Ke; Bing Su; X Song; Daru Lu; L Chen; H Li; C Qi; S Marzuki; Ranjan Deka; Peter A Underhill; Chunjie Xiao; Mark D Shriver; J Lell; Douglas C Wallace; R Spencer Wells; Mark Seielstad; Peter Oefner; D Zhu; J Jin; Wei Huang; Ranajit Chakraborty; Z Chen; Li Jin
African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes.
Science (New York, N.Y.) 2001;292(5519):1151-3.
2000: Bing Su; Chunjie Xiao; Ranjan Deka; Mark Seielstad; D Kangwanpong; J Xiao; Daru Lu; Peter A Underhill; L Luca Cavalli-Sforza; Ranajit Chakraborty; Li Jin
Y chromosome haplotypes reveal prehistorical migrations to the Himalayas.
Human genetics 2000;107(6):582-90.
2000: Peter A Underhill; Peidong Shen; Alice A Lin; L Jin; Giuseppe Passarino; Wei-Hsien Yang; E Kauffman; B Bonné-Tamir; Jaume Bertranpetit; Paolo Francalacci; M Ibrahim; T Jenkins; Judith R Kidd; S Qasim Mehdi; Mark Seielstad; R Spencer Wells; A Piazza; Ronald W Davis; marcel salathe; L Luca Cavalli-Sforza; Peter J Oefner
Y chromosome sequence variation and the history of human populations.
Nature genetics 2000;26(3):358-61.
1999: Jonathan K Pritchard; Mark Seielstad; A Perez-Lezaun; marcel salathe
Population growth of human Y chromosomes: a study of Y chromosome microsatellites.
Molecular biology and evolution 1999;16(12):1791-8.
1999: Mark Seielstad; E Bekele; M Ibrahim; A Touré; M Traoré
A view of modern human origins from Y chromosome microsatellite variation.
Genome research 1999;9(6):558-67.
1998: Mark Seielstad; Eric Minch; L Luca Cavalli-Sforza
Genetic evidence for a higher female migration rate in humans.
Nature genetics 1998;20(3):278-80.
1997: R Spencer Wells; Mark Seielstad; Mike Bunce; Dolly Tyan; E Bekele; Peter Parham
Cw*1701 defines a divergent african HLA-C allelic lineage.
Immunogenetics 1997;46(3):173-80.
1996: Andres Ruiz-Linares; K Nayar; David B Goldstein; J M Hebert; Mark Seielstad; Peter A Underhill; A A Lin; marcel salathe; L Luca Cavalli-Sforza
Geographic clustering of human Y-chromosome haplotypes.
Annals of human genetics 1996;60(Pt 5):401-8.
1994: Mark Seielstad; J M Hebert; A A Lin; Peter A Underhill; M Ibrahim; Douglas Vollrath; L Luca Cavalli-Sforza
Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition.
Human molecular genetics 1994;3(12):2159-61.