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Roland Seifert

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Co-Publications
Name
25
Wenzel-Seifert, Katharina
24
Schultz, Günter
17
Buschauer, Armin
13
Gille, Andreas
12
Klinker, JF
12
Kobilka, Brian
9
Gether, Ulrik
9
Dove, Stefan
9
Elz, Sigurd
8
Mou, Tung-Chung
7
Ghorai, Prasanta
7
Schunack, Walter
7
Offermanns, Stefan
6
Lushington, Gerald
6
Strasser, Andrea

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Publications

TOP 3
Suryanarayana Srividya; Pinto Cibele; Mou Tung-Chung; Richter Mark; Lushington Gerald H; Seifert Roland
The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity.
Igel Patrick; Geyer Roland; Strasser Andrea; Dove Stefan; Seifert Roland; Buschauer Armin
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
Suryanarayana Srividya; Göttle Martin; Hübner Melanie; Gille Andreas; Mou Tung-Chung; Sprang Stephen R; Richter Mark; Seifert Roland
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates.

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All Publications

2009: Suryanarayana Srividya; Pinto Cibele; Mou Tung-Chung; Richter Mark; Lushington Gerald H; Seifert Roland
The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity.
Neuroscience letters 2009;467(1):1-5.
2009: Igel Patrick; Geyer Roland; Strasser Andrea; Dove Stefan; Seifert Roland; Buschauer Armin
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
Journal of medicinal chemistry 2009;52(20):6297-313.
2009: Suryanarayana Srividya; Göttle Martin; Hübner Melanie; Gille Andreas; Mou Tung-Chung; Sprang Stephen R; Richter Mark; Seifert Roland
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates.
The Journal of pharmacology and experimental therapeutics 2009;330(3):687-95.
2009: Schneider Erich H; Seifert Roland
Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands.
Biochemical pharmacology 2009;78(6):607-16.
2009: Suryanarayana Srividya; Wang Jenna L; Richter Mark; Shen Yuequan; Tang Wei-Jen; Lushington Gerald H; Seifert Roland
Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.
Biochemical pharmacology 2009;78(3):224-30.
2009: Pinto Cibele; Hübner Melanie; Gille Andreas; Richter Mark; Mou Tung-Chung; Sprang Stephen R; Seifert Roland
Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.
Biochemical pharmacology 2009;78(1):62-9.
2009: Wittmann Hans-Joachim; Seifert Roland; Strasser Andrea
Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H(1)-receptor.
Molecular pharmacology 2009;76(1):25-37.
2009: Igel Patrick; Schneider Erich; Schnell David; Elz Sigurd; Seifert Roland; Buschauer Armin
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
Journal of medicinal chemistry 2009;52(8):2623-7.
2009: Strasser Andrea; Wittmann Hans-Joachim; Kunze Marc; Elz Sigurd; Seifert Roland
Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor.
Molecular pharmacology 2009;75(3):454-65.
2009: Schneider Erich H; Schnell David; Papa Dan; Seifert Roland
High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor.
Biochemistry 2009;48(6):1424-38.
2009: Igel Patrick; Schnell David; Bernhardt Günther; Seifert Roland; Buschauer Armin
Tritium-labeled N(1)-[3-(1H-imidazol-4-yl)propyl]-N(2)-propionylguanidine ([(3)H]UR-PI294), a high-affinity histamine H(3) and H(4) receptor radioligand.
ChemMedChem 2009;4(2):225-31.
2009: Kraus Anja; Ghorai Prasanta; Birnkammer Tobias; Schnell David; Elz Sigurd; Seifert Roland; Dove Stefan; Bernhardt Günther; Buschauer Armin
N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists.
ChemMedChem 2009;4(2):232-40.
2008: Nickl Kathrin; Gardner Eric E; Geiger Sarah; Heilmann Jörg; Seifert Roland
Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2.
Neuroscience letters 2008;447(1):68-72.
2008: Weitl Nina; Seifert Roland
Distinct interactions of human beta1- and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine.
The Journal of pharmacology and experimental therapeutics 2008;327(3):760-9.
2008: Ghorai Prasanta; Kraus Anja; Keller Max; Götte Carsten; Igel Patrick; Schneider Erich; Schnell David; Bernhardt Günther; Dove Stefan; Zabel Manfred; Elz Sigurd; Seifert Roland; Buschauer Armin
Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.
Journal of medicinal chemistry 2008;51(22):7193-204.
2008: Spangler Corinna M; Spangler Christian; Göttle Martin; Shen Yuequan; Tang Wei-Jen; Seifert Roland; Schäferling Michael
A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin.
Analytical biochemistry 2008;381(1):86-93.
2008: Strasser Andrea; Wittmann Hans-Joachim; Seifert Roland
Ligand-specific contribution of the N terminus and E2-loop to pharmacological properties of the histamine H1-receptor.
The Journal of pharmacology and experimental therapeutics 2008;326(3):783-91.
2008: Kleemann Patrick; Papa Dan; Vigil-Cruz Sandy; Seifert Roland
Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(3):261-74.
2008: Dove Stefan; Seifert Roland; Elz Sigurd; Buschauer Armin
Frontiers in medicinal chemistry in Regensburg.
ChemMedChem 2008;3(8):1181-4.
2008: Pinto Cibele; Papa Dan; Hübner Melanie; Mou Tung-Chung; Lushington Gerald H; Seifert Roland
Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.
The Journal of pharmacology and experimental therapeutics 2008;325(1):27-36.
2008: Strasser Andrea; Striegl Birgit; Wittmann Hans-Joachim; Seifert Roland
Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms.
The Journal of pharmacology and experimental therapeutics 2008;324(1):60-71.
2008: Egger Michael; Pellett Patrina; Nickl Kathrin; Geiger Sarah; Graetz Stephanie; Seifert Roland; Heilmann Jörg; König Burkhard
Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(35):10978-84.
2007: Preuss Hendrik; Ghorai Prasanta; Kraus Anja; Dove Stefan; Buschauer Armin; Seifert Roland
Point mutations in the second extracellular loop of the histamine H2 receptor do not affect the species-selective activity of guanidine-type agonists.
Naunyn-Schmiedeberg's archives of pharmacology 2007;376(4):253-64.
2007: Göttle Martin; Dove Stefan; Steindel Phillip; Shen Yuequan; Tang Wei-Jen; Geduhn Jens; König Burkhard; Seifert Roland
Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides.
Molecular pharmacology 2007;72(3):526-35.
2007: Kees F; Bucher M; Schweda F; Gschaidmeier H; Faerber L; Seifert R
Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun.
Naunyn-Schmiedeberg's archives of pharmacology 2007;375(6):393-9.
2007: Lorenz Veronika; Pinto Cibele S; Seifert Roland
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Neuroscience letters 2007;420(1):6-11.
2007: Preuss Hendrik; Ghorai Prasanta; Kraus Anja; Dove Stefan; Buschauer Armin; Seifert Roland
Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity.
The Journal of pharmacology and experimental therapeutics 2007;321(3):975-82.
2007: Preuss Hendrik; Ghorai Prasanta; Kraus Anja; Dove Stefan; Buschauer Armin; Seifert Roland
Constitutive activity and ligand selectivity of human, guinea pig, rat, and canine histamine H2 receptors.
The Journal of pharmacology and experimental therapeutics 2007;321(3):983-95.
2007: Wang Jenna L; Guo Jian-Xin; Zhang Qi-Yuan; Wu Jay J-Q; Seifert Roland; Lushington Gerald H
A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors.
Bioorganic & medicinal chemistry 2007;15(8):2993-3002.
2007: Xie Sheng-Xue; Schalkhausser Fabian; Ye Qi-Zhuang; Seifert Roland; Buschauer Armin
Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors.
Archiv der Pharmazie 2007;340(1):9-16.
2006: Pertz Heinz H; Görnemann Tilo; Schurad Björn; Seifert Roland; Strasser Andrea
Striking differences of action of lisuride stereoisomers at histamine H1 receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2006;374(3):215-22.
2006: Mou Tung-Chung; Gille Andreas; Suryanarayana Srividya; Richter Mark; Seifert Roland; Sprang Stephen R
Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.
Molecular pharmacology 2006;70(3):878-86.
2006: Xie Sheng-Xue; Petrache Georgiana; Schneider Erich; Ye Qi-Zhuang; Bernhardt Günther; Seifert Roland; Buschauer Armin
Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.
Bioorganic & medicinal chemistry letters 2006;16(15):3886-90.
2006: Xie Sheng-Xue; Kraus Anja; Ghorai Prasanta; Ye Qi-Zhuang; Elz Sigurd; Buschauer Armin; Seifert Roland
N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1262-8.
2006: Xie Sheng-Xue; Ghorai Prasanta; Ye Qi-Zhuang; Buschauer Armin; Seifert Roland
Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines.
The Journal of pharmacology and experimental therapeutics 2006;317(1):139-46.
2006: Pinto Cibele S; Seifert Roland
Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes.
Journal of neurochemistry 2006;96(2):454-9.
2005: Gille Andreas; Guo Jianxin; Mou Tung-Chung; Doughty Michael B; Lushington Gerald H; Seifert Roland
Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[gamma-thio]triphosphates and nucleoside 5'-[beta,gamma-imido]triphosphates.
Biochemical pharmacology 2005;71(1-2):89-97.
2005: Pinto Cibele S; Jinnah Hyder A; Shirley Thomas L; Nyhan William L; Seifert Roland
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Journal of neurochemistry 2005;93(6):1579-86.
2005: Mou Tung-Chung; Gille Andreas; Fancy David A; Seifert Roland; Sprang Stephen R
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
The Journal of biological chemistry 2005;280(8):7253-61.
2004: Dove Stefan; Elz Sigurd; Seifert Roland; Buschauer Armin
Structure-activity relationships of histamine H2 receptor ligands.
Mini reviews in medicinal chemistry 2004;4(9):941-54.
2004: Gille Andreas; Lushington Gerald H; Mou Tung-Chung; Doughty Michael B; Johnson Roger A; Seifert Roland
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
The Journal of biological chemistry 2004;279(19):19955-69.
2004: Gille Andreas; Seifert Roland
Xanthine nucleotide-specific G-protein alpha-subunits: a novel approach for the analysis of G-protein-mediated signal transduction.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(2):141-50.
2003: Menghin Sonja; Pertz Heinz H; Kramer Kai; Seifert Roland; Schunack Walter; Elz Sigurd
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.
Journal of medicinal chemistry 2003;46(25):5458-70.
2003: Gille Andreas; Seifert Roland
MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors.
Life sciences 2003;74(2-3):271-9.
2003: Seifert Roland; Wenzel-Seifert Katharina
The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors.
Life sciences 2003;73(18):2263-80.
2003: Gille Andreas; Seifert Roland
Low-affinity interactions of BODIPY-FL-GTPgammaS and BODIPY-FL-GppNHp with G(i)- and G(s)-proteins.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(3):210-5.
2003: Gille Andreas; Seifert Roland
Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins.
Biochimica et biophysica acta 2003;1613(1-2):101-14.
2003: Seifert Roland; Wenzel-Seifert Katharina; Burckstummer Tilmann; Pertz Heinz H; Schunack Walter; Dove Stefan; Buschauer Armin; Elz Sigurd
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1104-15.
2003: Wenzel-Seifert Katharina; Seifert Roland
Functional differences between human formyl peptide receptor isoforms 26, 98, and G6.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(5):509-15.
2003: Gille Andreas; Seifert Roland
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.
The Journal of biological chemistry 2003;278(15):12672-9.
2003: Gille Andreas; Wenzel-Seifert Katharina; Doughty Michael B; Seifert Roland
GDP affinity and order state of the catalytic site are critical for function of xanthine nucleotide-selective Galphas proteins.
The Journal of biological chemistry 2003;278(10):7822-8.
2003: Wenzel-Seifert Katharina; Seifert Roland
Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor.
Biochemical and biophysical research communications 2003;301(3):693-8.
2003: Wenzel-Seifert Katharina; Seifert Roland
Properties of Arg389-beta1-adrenoceptor-Gsalpha fusion proteins: comparison with Gly389-beta1-adrenoceptor-Gsalpha fusion proteins.
Receptors & channels 2003;9(5):315-23.
2002: Seifert Roland; Wenzel-Seifert Katharina; Arthur John M; Jose Powell O; Kobilka Brian K
Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein.
Biochemical and biophysical research communications 2002;298(5):824-8.
2002: Seifert Roland; Wenzel-Seifert Katharina
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(5):381-416.
2002: Gille Andreas; Liu Hui-Yu; Sprang Stephen R; Seifert Roland
Distinct interactions of GTP, UTP, and CTP with G(s) proteins.
The Journal of biological chemistry 2002;277(37):34434-42.
2002: Liu Hui-Yu; Seifert Roland
Distinct interactions of G(salpha-long), G(salpha-short), and G(alphaolf) with GTP, ITP, and XTP.
Biochemical pharmacology 2002;64(4):583-93.
2002: Wenzel-Seifert Katharina; Liu Hui Yu; Seifert Roland
Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.
Biochemical pharmacology 2002;64(1):9-20.
2002: Houston Christine; Wenzel-Seifert Katharina; Bürckstümmer Tilmann; Seifert Roland
The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling.
Journal of neurochemistry 2002;80(4):678-96.
2001: Kelley M T; Bürckstümmer T; Wenzel-Seifert K; Dove S; Buschauer A; Seifert R
Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists.
Molecular pharmacology 2001;60(6):1210-25.
2001: Wenzel-Seifert K; Kelley M T; Buschauer A; Seifert R
Similar apparent constitutive activity of human histamine H(2)-receptor fused to long and short splice variants of G(salpha).
The Journal of pharmacology and experimental therapeutics 2001;299(3):1013-20.
2001: Seifert R; Wenzel-Seifert K
Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis.
The Journal of biological chemistry 2001;276(45):42043-9.
2001: Seifert R
Monovalent anions differentially modulate coupling of the beta2-adrenoceptor to G(s)alpha splice variants.
The Journal of pharmacology and experimental therapeutics 2001;298(2):840-7.
2001: Liu H Y; Wenzel-Seifert K; Seifert R
The olfactory G protein G(alphaolf) possesses a lower GDP-affinity and deactivates more rapidly than G(salphashort): consequences for receptor-coupling and adenylyl cyclase activation.
Journal of neurochemistry 2001;78(2):325-38.
2001: Seifert R; Wenzel-Seifert K; Gether U; Kobilka B K
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1218-26.
2001: Seifert R; Wenzel-Seifert K
Unmasking different constitutive activity of four chemoattractant receptors using Na+ as universal stabilizer of the inactive (R) state.
Receptors & channels 2001;7(5):357-69.
2000: Wenzel-Seifert K; Seifert R
Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.
Molecular pharmacology 2000;58(5):954-66.
2000: Ghanouni P; Schambye H; Seifert R; Lee T W; Rasmussen S G; Gether U; Kobilka B K
The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.
The Journal of biological chemistry 2000;275(5):3121-7.
1999: Wenzel-Seifert K; Arthur J M; Liu H Y; Seifert R
Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3).
The Journal of biological chemistry 1999;274(47):33259-66.
1999: Lee T W; Seifert R; Guan X; Kobilka B K
Restricting the mobility of Gs alpha: impact on receptor and effector coupling.
Biochemistry 1999;38(42):13801-9.
1999: Seifert R; Wenzel-Seifert K; Kobilka B K
GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling.
Trends in pharmacological sciences 1999;20(9):383-9.
1999: Klinker J F; Seifert R
Interaction of the retinal G-protein transducin with uracil nucleotides.
Biochemical and biophysical research communications 1999;262(2):341-5.
1999: Seifert R; Gether U; Wenzel-Seifert K; Kobilka B K
Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations.
Molecular pharmacology 1999;56(2):348-58.
1999: Klinker J F; Seifert R
Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate.
European journal of biochemistry / FEBS 1999;261(1):72-80.
1999: Seifert R; Wenzel-Seifert K; Gether U; Lam V T; Kobilka B K
Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein.
European journal of biochemistry / FEBS 1999;260(3):661-6.
1999: Kobilka B; Gether U; Seifert R; Lin S; Ghanouni P
Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor.
Journal of receptor and signal transduction research 1999;19(1-4):293-300.
1998: Wenzel-Seifert K; Lee T W; Seifert R; Kobilka B K
Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity.
The Biochemical journal 1998;334 ( Pt 3)():519-24.
1998: Wenzel-Seifert K; Hurt C M; Seifert R
High constitutive activity of the human formyl peptide receptor.
The Journal of biological chemistry 1998;273(37):24181-9.
1998: Seifert R; Lee T W; Lam V T; Kobilka B K
Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein.
European journal of biochemistry / FEBS 1998;255(2):369-82.
1998: Seifert R; Wenzel-Seifert K; Lee T W; Gether U; Sanders-Bush E; Kobilka B K
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.
The Journal of biological chemistry 1998;273(18):5109-16.
1998: Seifert R; Wenzel-Seifert K; Lee T W; Gether U; Sanders-Bush E; Kobilka B K
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.
The Journal of biological chemistry 1998;273(9):5109-16.
1998: Kobilka B; Gether U; Seifert R; Lin S; Ghanouni P
Examination of ligand-induced conformational changes in the beta2 adrenergic receptor.
Life sciences 1998;62(17-18):1509-12.
1997: Klinker J F; Seifert R
Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes.
Biochemical pharmacology 1997;54(5):551-62.
1997: Klinker J F; Seifert R; Damm H; Rommelspacher H
Activation by beta-carbolines of G-proteins in HL-60 membranes and the bovine retinal G-protein transducin in a receptor-independent manner.
Biochemical pharmacology 1997;53(11):1621-6.
1997: Wenzel-Seifert K; Lentzen H; Aktories K; Seifert R
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways.
Journal of leukocyte biology 1997;61(6):703-11.
1997: Klinker J F; Seifert R
Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(2):46-50.
1997: Wenzel-Seifert K; Lentzen H; Seifert R
In U-937 promonocytes, misteltoe lectin I increases basal [Ca2+]i, enhances histamine H1- and complement C5a-receptor-mediated rises in [Ca2+]i, and induces cell death.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(2):190-7.
1997: Gether U; Ballesteros J A; Seifert R; Sanders-Bush E; Weinstein H; Kobilka B K
Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility.
The Journal of biological chemistry 1997;272(5):2587-90.
1996: Wenzel-Seifert K; Krautwurst D; Lentzen H; Seifert R
Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels.
Journal of leukocyte biology 1996;60(3):345-55.
1996: Wenzel-Seifert K; Krautwurst D; Musgrave I; Seifert R
Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway.
The Biochemical journal 1996;314 ( Pt 2)():679-86.
1996: Klinker J F; Laugwitz K L; Hagelüken A; Seifert R
Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action.
Biochemical pharmacology 1996;51(3):217-23.
1996: Klinker J F; Wenzel-Seifert K; Seifert R
G-protein-coupled receptors in HL-60 human leukemia cells.
General pharmacology 1996;27(1):33-54.
1996: Burde R; Seifert R
Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-trans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(2):123-9.
1996: Burde R; Dippel E; Seifert R
Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells.
Biochemical pharmacology 1996;51(2):125-31.
1995: Klinker J F; Hagelüken A; Grünbaum L; Seifert R
Direct and indirect receptor-independent G-protein activation by cationic-amphiphilic substances. Studies with mast cells, HL-60 human leukemic cells and purified G-proteins.
Experimental dermatology 1995;4(4 Pt 2):231-9.
1995: Klinker J F; Seifert R
Synthetic lipopeptides activate nucleoside diphosphate kinase in HL-60 membranes.
Biochemical and biophysical research communications 1995;209(2):575-81.
1995: Hagelüken A; Grünbaum L; Klinker J F; Nürnberg B; Harhammer R; Schultz G; Leschke C; Schunack W; Seifert R
Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells.
Biochemical pharmacology 1995;49(7):901-914.
1995: Hagelüken A; Burde R; Nürnberg B; Harhammer R; Buschauer A; Seifert R
Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(3):305-8.
1995: Hagelüken A; Nürnberg B; Harhammer R; Grünbaum L; Schunack W; Seifert R
The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins.
Molecular pharmacology 1995;47(2):234-40.
1995: Schwaner I; Offermanns S; Spicher K; Seifert R; Schultz G
Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.
Biochimica et biophysica acta 1995;1265(1):8-14.
1995: Musgrave I F; Seifert R
Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium.
Biochemical pharmacology 1995;49(2):187-96.
1994: Klinker J F; Schwaner I; Offermanns S; Hagelüken A; Seifert R
Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants.
Biochemical pharmacology 1994;48(10):1857-64.
1994: Walzog B; Seifert R; Zakrzewicz A; Gaehtgens P; Ley K
Cross-linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up-regulation of CD18, shedding of L-selectin, and actin polymerization.
Journal of leukocyte biology 1994;56(5):625-35.
1994: Wenzel-Seifert K; Schächtele C; Hummel R; Grünbaum L; Seifert R
Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C.
Biochemical pharmacology 1994;48(5):859-64.
1994: Musgrave I F; Seifert R; Schultz G
Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells.
The Biochemical journal 1994;301 ( Pt 2)():437-41.
1994: Berg M; Offermanns S; Seifert R; Schultz G
Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets.
The American journal of physiology 1994;266(6 Pt 1):C1684-91.
1994: Wenzel-Seifert K; Schächtele C; Seifert R
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions.
Biochemical and biophysical research communications 1994;200(3):1536-43.
1994: Hagelüken A; Grünbaum L; Nürnberg B; Harhammer R; Schunack W; Seifert R
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Biochemical pharmacology 1994;47(10):1789-95.
1994: Seifert R; Grünbaum L; Schultz G
Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(4):355-61.
1994: Seifert R; Hagelüken A; Höer A; Höer D; Grünbaum L; Offermanns S; Schwaner I; Zingel V; Schunack W; Schultz G
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
Molecular pharmacology 1994;45(4):578-86.
1994: Naim M; Seifert R; Nürnberg B; Grünbaum L; Schultz G
Some taste substances are direct activators of G-proteins.
The Biochemical journal 1994;297 ( Pt 3)():451-4.
1994: Musgrave I F; Seifert R
Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors.
Biochemical pharmacology 1994;47(2):233-9.
1993: Klinker J F; Höer A; Schwaner I; Offermanns S; Wenzel-Seifert K; Seifert R
Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.
The Biochemical journal 1993;296 ( Pt 1)():245-51.
1993: Wenzel-Seifert K; Seifert R
Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations.
Naunyn-Schmiedeberg's archives of pharmacology 1993;348(1):7-13.
1993: Wenzel-Seifert K; Seifert R
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4591-9.
1993: Musgrave I F; Genieser H G; Maronde E; Seifert R
Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine.
FEBS letters 1993;318(3):227-30.
1992: Krautwurst D; Seifert R; Hescheler J; Schultz G
Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.
The Biochemical journal 1992;288 ( Pt 3)():1025-35.
1992: Seifert R; Höer A; Schwaner I; Buschauer A
Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation.
Molecular pharmacology 1992;42(2):235-41.
1992: Seifert R; Höer A; Offermanns S; Buschauer A; Schunack W
Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue.
Molecular pharmacology 1992;42(2):227-34.
1992: Ervens J; Seifert R
Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism.
Biochemical pharmacology 1992;44(4):637-44.
1992: Klinz F J; Seifert R; Schwaner I; Gausepohl H; Frank R; Schultz G
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells.
European journal of biochemistry / FEBS 1992;207(1):207-13.
1992: Offermanns S; Seifert R; Metzger J W; Jung G; Lieberknecht A; Schmidt U; Schultz G
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
The Biochemical journal 1992;282 ( Pt 2)():551-7.
1992: Schwaner I; Seifert R; Schultz G
Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways.
The Biochemical journal 1992;281 ( Pt 2)():301-7.
1992: Seifert R; Serke S; Huhn D; Bessler W G; Hauschildt S; Metzger J; Wismüller K H; Jung G
Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation.
European journal of biochemistry / FEBS 1992;203(1-2):143-51.
1992: Schwaner I; Seifert R; Schultz G
The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins.
Eicosanoids 1992;5 Suppl():S10-2.
1991: Wenzel-Seifert K; Ervens J; Seifert R
Differential inhibition and potentiation by cell-permeant analogues of cyclic AMP and cyclic GMP and NO-containing compounds of exocytosis in human neutrophils.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(4):396-402.
1991: Wenzel-Seifert K; Grünbaum L; Seifert R
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1940-6.
1991: Ervens J; Schultz G; Seifert R
Differential inhibition and potentiation of chemoattractant-induced superoxide formation in human neutrophils by the cell-permeant analogue of cyclic GMP, N2,2'-O-dibutyryl guanosine 3':5'-cyclic monophosphate.
Naunyn-Schmiedeberg's archives of pharmacology 1991;343(4):370-6.
1991: Seifert R; Hilgenstock G; Fassbender M; Distler A
Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension.
Journal of hypertension 1991;9(2):147-53.
1991: Ervens J; Schultz G; Seifert R
Differential regulation of chemoattractant-induced superoxide formation in human neutrophils by cell-permeant analogues of cyclic AMP and cyclic GMP.
Biochemical Society transactions 1991;19(1):59-63.
1991: Ervens J; Seifert R
Differential modulation by N4, 2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate of neutrophil activation.
Biochemical and biophysical research communications 1991;174(1):258-67.
1991: Seifert R; Schultz G
The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms.
Reviews of physiology, biochemistry and pharmacology 1991;117():1-338.
1990: Seifert R; Schultz G; Richter-Freund M; Metzger J; Wiesmüller K H; Jung G; Bessler W G; Hauschildt S
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.
The Biochemical journal 1990;267(3):795-802.
1990: Burde R; Buschauer A; Seifert R
Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Are cell type-specific H2-receptors involved in the regulation of NADPH oxidase?
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(5):455-61.
1989: Burde R; Seifert R; Buschauer A; Schultz G
Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6):671-8.
1989: Seifert R; Burde R; Schultz G
Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(1):101-6.
1989: Seifert R; Jungblut P; Schultz G
Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells.
Biochemical and biophysical research communications 1989;161(3):1109-17.
1989: Seifert R; Burde R; Schultz G
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides.
The Biochemical journal 1989;259(3):813-9.
1989: Seifert R; Wenzel K; Eckstein F; Schultz G
Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins.
European journal of biochemistry / FEBS 1989;181(1):277-85.
1989: Schmidt H H; Seifert R; Böhme E
Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4.
FEBS letters 1989;244(2):357-60.
1988: Seifert R; Schächtele C; Rosenthal W; Schultz G
Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol.
Biochemical and biophysical research communications 1988;154(1):20-6.
1988: Seifert R; Rosenthal W; Schultz G; Wieland T; Gierschick P; Jakobs K H
The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides.
European journal of biochemistry / FEBS 1988;175(1):51-5.
1988: Seifert R; Schächtele C
Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase.
Biochemical and biophysical research communications 1988;152(2):585-92.
1987: Seifert R; Schächtele C; Schultz G
Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol.
Biochemical and biophysical research communications 1987;149(2):762-8.

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