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Motoharu Seiki

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
36
Sato, Hiroshi
20
Itoh, Yoshifumi
13
Yana, Ikuo
10
Okada, Yasunori
9
Uekita, Takamasa
9
Koshikawa, Naohiko
8
Miyamori, Hisashi
8
Kajita, Masahiro
7
Kinoh, Hiroaki
7
Takino, Takahisa
7
Okada, Atsushi
6
Tojo, Hideaki
6
Mori, Hidetoshi
5
Mai, Masayoshi
5
Suenaga, Naoko

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Publications

TOP 3
Sakamoto Takeharu; Seiki Motoharu
Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.
Niiya Daigo; Egawa Nagayasu; Sakamoto Takeharu; Kikkawa Yamato; Shinkawa Takashi; Isobe Toshiaki; Koshikawa Naohiko; Seiki Motoharu
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.
Hoshino Daisuke; Tomari Taizo; Nagano Makoto; Koshikawa Naohiko; Seiki Motoharu
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.

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All Publications

2009: Sakamoto Takeharu; Seiki Motoharu
Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.
The Journal of biological chemistry 2009;284(44):30350-9.
2009: Niiya Daigo; Egawa Nagayasu; Sakamoto Takeharu; Kikkawa Yamato; Shinkawa Takashi; Isobe Toshiaki; Koshikawa Naohiko; Seiki Motoharu
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.
The Journal of biological chemistry 2009;284(40):27360-9.
2009: Hoshino Daisuke; Tomari Taizo; Nagano Makoto; Koshikawa Naohiko; Seiki Motoharu
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.
The Journal of biological chemistry 2009;284(40):27315-26.
2009: Tomari Taizo; Koshikawa Naohiko; Uematsu Takayuki; Shinkawa Takashi; Hoshino Daisuke; Egawa Nagayasu; Isobe Toshiaki; Seiki Motoharu
High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells.
Cancer science 2009;100(7):1284-90.
2009: Sakamoto Takeharu; Seiki Motoharu
Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(5):617-26.
2009: Miller Mary-Clare; Manning Hugh B; Jain Abhilash; Troeberg Linda; Dudhia Jayesh; Essex David; Sandison Ann; Seiki Motoharu; Nanchahal Jagdeep; Nagase Hideaki; Itoh Yoshifumi
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis.
Arthritis and rheumatism 2009;60(3):686-97.
2008: Itoh Yoshifumi; Ito Noriko; Nagase Hideaki; Seiki Motoharu
The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.
The Journal of biological chemistry 2008;283(19):13053-62.
2008: Koshikawa Naohiko; Minegishi Tomoko; Nabeshima Kazuki; Seiki Motoharu
Development of a new tracking tool for the human monomeric laminin-gamma 2 chain in vitro and in vivo.
Cancer research 2008;68(2):530-6.
2008: Imai Misa; Muraki Miho; Takamatsu Kiyoshi; Saito Hidekazu; Seiki Motoharu; Takahashi Yuji
Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line.
BMC cancer 2008;8():319.
2007: Rikimaru Akiko; Komori Kiyoshi; Sakamoto Takeharu; Ichise Hirotake; Yoshida Nobuaki; Yana Ikuo; Seiki Motoharu
Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(9):1091-100.
2007: Taniwaki Kaori; Fukamachi Hiroshi; Komori Kiyoshi; Ohtake Yohei; Nonaka Takahiro; Sakamoto Takeharu; Shiomi Takayuki; Okada Yasunori; Itoh Takeshi; Itohara Shigeyoshi; Seiki Motoharu; Yana Ikuo
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.
Cancer research 2007;67(9):4311-9.
2007: Yana Ikuo; Sagara Hiroshi; Takaki Satoshi; Takatsu Kiyoshi; Nakamura Kenji; Nakao Kazuki; Katsuki Motoya; Taniguchi Shun-ichiro; Aoki Takanori; Sato Hiroshi; Weiss Stephen J; Seiki Motoharu
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.
Journal of cell science 2007;120(Pt 9):1607-14.
2007: Gotoh Isamu; Uekita Takamasa; Seiki Motoharu
Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(1):105-17.
2006: Itoh Yoshifumi; Ito Noriko; Nagase Hideaki; Evans Richard D; Bird Sarah A; Seiki Motoharu
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.
Molecular biology of the cell 2006;17(12):5390-9.
2006: Egawa Nagayasu; Koshikawa Naohiko; Tomari Taizo; Nabeshima Kazuki; Isobe Toshiaki; Seiki Motoharu
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.
The Journal of biological chemistry 2006;281(49):37576-85.
2006: Hikita Atsuhiko; Yana Ikuo; Wakeyama Hidetoshi; Nakamura Masaki; Kadono Yuho; Oshima Yasushi; Nakamura Kozo; Seiki Motoharu; Tanaka Sakae
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand.
The Journal of biological chemistry 2006;281(48):36846-55.
2006: Ohtake Yohei; Tojo Hideaki; Seiki Motoharu
Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscle.
Journal of cell science 2006;119(Pt 18):3822-32.
2006: Takino Takahisa; Watanabe Yumi; Matsui Miyuki; Miyamori Hisashi; Kudo Tomoya; Seiki Motoharu; Sato Hiroshi
Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration.
Experimental cell research 2006;312(8):1381-9.
2006: Lafleur Marc A; Mercuri Francesca A; Ruangpanit Neeracha; Seiki Motoharu; Sato Hiroshi; Thompson Erik W
Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain.
The Journal of biological chemistry 2006;281(10):6826-40.
2006: Itoh Yoshifumi; Seiki Motoharu
MT1-MMP: a potent modifier of pericellular microenvironment.
Journal of cellular physiology 2006;206(1):1-8.
2005: Nonaka Takahiro; Nishibashi Kunika; Itoh Yoshifumi; Yana Ikuo; Seiki Motoharu
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Molecular cancer therapeutics 2005;4(8):1157-66.
2005: Anilkumar Narayanapanicker; Uekita Takamasa; Couchman John R; Nagase Hideaki; Seiki Motoharu; Itoh Yoshifumi
Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1326-8.
2005: Hirano Wakako; Gotoh Isamu; Uekita Takamasa; Seiki Motoharu
Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(6):565-74.
2005: Bai Shan; Thummel Ryan; Godwin Alan R; Nagase Hideaki; Itoh Yoshifumi; Li Li; Evans Richard; McDermott Jeffrey; Seiki Motoharu; Sarras Michael P
Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(4):247-60.
2005: Irie Kazuharu; Komori Kiyoshi; Seiki Motoharu; Tsuruga Eichi; Sakakura Yasunori; Kaku Tohru; Yajima Toshihiko
Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP).
Medical molecular morphology 2005;38(1):43-6.
2005: Suenaga Naoko; Mori Hidetoshi; Itoh Yoshifumi; Seiki Motoharu
CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase.
Oncogene 2005;24(5):859-68.
2005: Koshikawa Naohiko; Minegishi Tomoko; Sharabi Andrew; Quaranta Vito; Seiki Motoharu
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain.
The Journal of biological chemistry 2005;280(1):88-93.
2004: Uekita T; Yamanouchi K; Sato H; Tojo H; Seiki M; Tachi C
Expression and localization of matrix metalloproteinases (MT1-MMP, MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) during synepitheliochorial placentation of goats (Capra hircus).
Placenta 2004;25(10):810-9.
2004: Murai Shinji; Umemiya Toshifumi; Seiki Motoharu; Harigaya Kenichi
Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.
Virchows Archiv : an international journal of pathology 2004;445(3):271-8.
2004: Funato Yosuke; Terabayashi Takeshi; Suenaga Naoko; Seiki Motoharu; Takenawa Tadaomi; Miki Hiroaki
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.
Cancer research 2004;64(15):5237-44.
2004: Itoh Yoshifumi; Seiki Motoharu
MT1-MMP: an enzyme with multidimensional regulation.
Trends in biochemical sciences 2004;29(6):285-9.
2004: Oh Junseo; Takahashi Rei; Adachi Eijiro; Kondo Shunya; Kuratomi Shinobu; Noma Akinori; Alexander David B; Motoda Hirotoshi; Okada Akiko; Seiki Motoharu; Itoh Takeshi; Itohara Shigeyoshi; Takahashi Chiaki; Noda Makoto
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.
Oncogene 2004;23(29):5041-8.
2004: Kayano Kaori; Shimada Taketoshi; Shinomiya Takashi; Nakai Shigeru; Hisa Yasuo; Aoki Takanori; Seiki Motoharu; Okada Yasunori
Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: possible regulation of pro-MMP-2 activation by TIMP-2.
The Journal of pathology 2004;202(4):403-11.
2004: Uekita Takamasa; Gotoh Isamu; Kinoshita Takeshi; Itoh Yoshifumi; Sato Hiroshi; Shiomi Takayuki; Okada Yasunori; Seiki Motoharu
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors.
The Journal of biological chemistry 2004;279(13):12734-43.
2004: Takino Takahisa; Miyamori Hisashi; Watanabe Yumi; Yoshioka Katsuji; Seiki Motoharu; Sato Hiroshi
Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration.
Cancer research 2004;64(3):1044-9.
2004: Nakamura Hiroyuki; Suenaga Naoko; Taniwaki Kaori; Matsuki Hirokazu; Yonezawa Kayoko; Fujii Masato; Okada Yasunori; Seiki Motoharu
Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase.
Cancer research 2004;64(3):876-82.
2004: Komori Kiyoshi; Nonaka Takahiro; Okada Akiko; Kinoh Hiroaki; Hayashita-Kinoh Hiromi; Yoshida Nobuaki; Yana Ikuo; Seiki Motoharu
Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase.
FEBS letters 2004;557(1-3):125-8.
2004: Yokoyama Takeyoshi; Nakamura Hiroyuki; Otani Yoshihide; Kubota Tetsuro; Fujimoto Noboru; Seiki Motoharu; Kitajima Masaki; Okada Yasunori
Differences between scirrhous and non-scirrhous human gastric carcinomas from the aspect of proMMP-2 activation regulated by TIMP-3.
Clinical & experimental metastasis 2004;21(3):223-33.
2003: Matsuki Hirokazu; Yonezawa Kayoko; Obata Ken'ichi; Iwata Kazushi; Nakamura Hiroyuki; Okada Yasunori; Seiki Motoharu
Monoclonal antibodies with defined recognition sequences in the stem region of CD44: detection of differential glycosylation of CD44 between tumor and stromal cells in tissue.
Cancer research 2003;63(23):8278-83.
2003: Fujita Masaki; Nakao Yoichi; Matsunaga Shigeki; Seiki Motoharu; Itoh Yoshifumi; Yamashita Jun; Van Soest Rob W M; Fusetani Nobuhiro
Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai.
Journal of the American Chemical Society 2003;125(51):15700-1.
2003: Ueda Junko; Kajita Masahiro; Suenaga Naoko; Fujii Katsuyuki; Seiki Motoharu
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors.
Oncogene 2003;22(54):8716-22.
2003: Matsuda Akira; Itoh Yoshifumi; Koshikawa Naohiko; Akizawa Toshifumi; Yana Ikuo; Seiki Motoharu
Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils.
The Journal of biological chemistry 2003;278(38):36350-7.
2003: Takino Takahisa; Koshikawa Naohiko; Miyamori Hisashi; Tanaka Motohiro; Sasaki Takuma; Okada Yasunori; Seiki Motoharu; Sato Hiroshi
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.
Oncogene 2003;22(30):4617-26.
2003: Seiki Motoharu; Yana Ikuo
Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis.
Cancer science 2003;94(7):569-74.
2003: Seiki Motoharu; Koshikawa Naohiko; Yana Ikuo
Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis.
Cancer metastasis reviews 2003;22(2-3):129-43.
2003: Seiki Motoharu
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.
Cancer letters 2003;194(1):1-11.
2003: Fujita Masaki; Nakao Yoichi; Matsunaga Shigeki; van Soest Rob W M; Itoh Yoshifumi; Seiki Motoharu; Fusetani Nobuhiro
Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata.
Journal of natural products 2003;66(4):569-71.
2003: Takino Takahisa; Miyamori Hisashi; Kawaguchi Noriko; Uekita Takamasa; Seiki Motoharu; Sato Hiroshi
Tetraspanin CD63 promotes targeting and lysosomal proteolysis of membrane-type 1 matrix metalloproteinase.
Biochemical and biophysical research communications 2003;304(1):160-6.
2003: Yana Ikuo; Seiki Motoharu
[Matrix metalloproteinases; the past, present, and future]
Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 2003;100(2):144-51.
2003: Seiki Motoharu; Mori Hidetoshi; Kajita Masahiro; Uekita Takamasa; Itoh Yoshifumi
Membrane-type 1 matrix metalloproteinase and cell migration.
Biochemical Society symposium 2003;(70):253-62.
2002: Seiki Motoharu
The cell surface: the stage for matrix metalloproteinase regulation of migration.
Current opinion in cell biology 2002;14(5):624-32.
2002: Sancéau Josiane; Boyd Douglas D; Seiki Motoharu; Bauvois Brigitte
Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B.
The Journal of biological chemistry 2002;277(38):35766-75.
2002: Takahashi Meiko; Tsunoda Tatsuhiko; Seiki Motoharu; Nakamura Yusuke; Furukawa Yoichi
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
Oncogene 2002;21(38):5861-7.
2002: Mori Hidetoshi; Tomari Taizo; Koshikawa Naohiko; Kajita Masahiro; Itoh Yoshifumi; Sato Hiroshi; Tojo Hideaki; Yana Ikuo; Seiki Motoharu
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.
The EMBO journal 2002;21(15):3949-59.
2002: Yana Ikuo; Seiki Motoharu
MT-MMPs play pivotal roles in cancer dissemination.
Clinical & experimental metastasis 2002;19(3):209-15.
2002: Aoki Takanori; Yonezawa Kayoko; Ohuchi Eiko; Fujimoto Noboru; Iwata Kazushi; Shimada Taketoshi; Shiomi Takayuki; Okada Yasunori; Seiki Motoharu
Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinase.
Journal of immunoassay & immunochemistry 2002;23(1):49-68.
2001: Uekita T; Itoh Y; Yana I; Ohno H; Seiki M
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity.
The Journal of cell biology 2001;155(7):1345-56.
2001: Oh J; Takahashi R; Kondo S; Mizoguchi A; Adachi E; Sasahara R M; Nishimura S; Imamura Y; Kitayama H; Alexander D B; Ide C; Horan T P; Arakawa T; Yoshida H; Nishikawa S; Itoh Y; Seiki M; Itohara S; Takahashi C; Noda M
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.
Cell 2001;107(6):789-800.
2001: Hayashita-Kinoh H; Kinoh H; Okada A; Komori K; Itoh Y; Chiba T; Kajita M; Yana I; Seiki M
Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(11):573-80.
2001: Uekita T; Tanaka S S; Sato H; Seiki M; Tojo H; Tachi C
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus).
Archives of histology and cytology 2001;64(4):411-24.
2001: Itoh Y; Takamura A; Ito N; Maru Y; Sato H; Suenaga N; Aoki T; Seiki M
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
The EMBO journal 2001;20(17):4782-93.
2001: Miyamori H; Takino T; Kobayashi Y; Tokai H; Itoh Y; Seiki M; Sato H
Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases.
The Journal of biological chemistry 2001;276(30):28204-11.
2001: Kajita M; Itoh Y; Chiba T; Mori H; Okada A; Kinoh H; Seiki M
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
The Journal of cell biology 2001;153(5):893-904.
2001: Hiratsuka S; Maru Y; Okada A; Seiki M; Noda T; Shibuya M
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.
Cancer research 2001;61(3):1207-13.
2000: Yamanaka H; Makino K; Takizawa M; Nakamura H; Fujimoto N; Moriya H; Nemori R; Sato H; Seiki M; Okada Y
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in rheumatoid synovium.
Laboratory investigation; a journal of technical methods and pathology 2000;80(5):677-87.
2000: Kim K R; Yoshizaki T; Miyamori H; Hasegawa K; Horikawa T; Furukawa M; Harada S; Seiki M; Sato H
Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth.
Oncogene 2000;19(14):1764-71.
2000: Miyamori H; Takino T; Seiki M; Sato H
Human membrane type-2 matrix metalloproteinase is defective in cell-associated activation of progelatinase A.
Biochemical and biophysical research communications 2000;267(3):796-800.
2000: Cha H J; Okada A; Kim K W; Sato H; Seiki M
Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells.
Clinical & experimental metastasis 2000;18(8):675-81.
2000: Shimada T; Nakamura H; Yamashita K; Kawata R; Murakami Y; Fujimoto N; Sato H; Seiki M; Okada Y
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Clinical & experimental metastasis 2000;18(2):179-88.
1999: Itoh Y; Kajita M; Kinoh H; Mori H; Okada A; Seiki M
Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.
The Journal of biological chemistry 1999;274(48):34260-6.
1999: Takahashi Y; Kawahara F; Noguchi M; Miwa K; Sato H; Seiki M; Inoue H; Tanabe T; Yoshimoto T
Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2.
FEBS letters 1999;460(1):145-8.
1999: Harayama T; Ohuchi E; Aoki T; Sato H; Seiki M; Okada Y
Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line.
Japanese journal of cancer research : Gann 1999;90(9):942-50.
1999: Kajita M; Kinoh H; Ito N; Takamura A; Itoh Y; Okada A; Sato H; Seiki M
Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts.
FEBS letters 1999;457(3):353-6.
1999: Shimada T; Nakamura H; Ohuchi E; Fujii Y; Murakami Y; Sato H; Seiki M; Okada Y
Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.
European journal of biochemistry / FEBS 1999;262(3):907-14.
1999: Noritake H; Miyamori H; Goto C; Seiki M; Sato H
Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in metastatic MDCK cells transformed by v-src.
Clinical & experimental metastasis 1999;17(2):105-10.
1999: Nakada M; Nakamura H; Ikeda E; Fujimoto N; Yamashita J; Sato H; Seiki M; Okada Y
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors.
The American journal of pathology 1999;154(2):417-28.
1999: Seiki M
Membrane-type matrix metalloproteinases.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):137-43.
1999: Seiki M
[Outline of tumor invasion and metastasis]
Gan to kagaku ryoho. Cancer & chemotherapy 1999;26(1):157-61.
1999: Nakamura H; Ueno H; Yamashita K; Shimada T; Yamamoto E; Noguchi M; Fujimoto N; Sato H; Seiki M; Okada Y
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.
Cancer research 1999;59(2):467-73.
1999: Kinoh H; Hayashita H; Kajita M; Okada A; Seiki M
Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->q12, respectively, by radiation hybrid and in situ hybridization.
Cytogenetics and cell genetics 1999;87(1-2):97-8.
1998: Yoshiyama Y; Sato H; Seiki M; Shinagawa A; Takahashi M; Yamada T
Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues.
Acta neuropathologica 1998;96(4):347-50.
1998: Kadono Y; Shibahara K; Namiki M; Watanabe Y; Seiki M; Sato H
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cells.
Biochemical and biophysical research communications 1998;251(3):681-7.
1998: Kitagawa Y; Kunimi K; Ito H; Sato H; Uchibayashi T; Okada Y; Seiki M; Namiki M
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.
The Journal of urology 1998;160(4):1540-5.
1998: Kinoshita T; Sato H; Okada A; Ohuchi E; Imai K; Okada Y; Seiki M
TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads.
The Journal of biological chemistry 1998;273(26):16098-103.
1998: Kadono Y; Okada Y; Namiki M; Seiki M; Sato H
Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness.
Cancer research 1998;58(10):2240-4.
1998: Wada K; Sato H; Kinoh H; Kajita M; Yamamoto H; Seiki M
Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases.
Gene 1998;211(1):57-62.
1998: Harada T; Arii S; Mise M; Imamura T; Higashitsuji H; Furutani M; Niwano M; Ishigami S; Fukumoto M; Seiki M; Sato H; Imamura M
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.
Journal of hepatology 1998;28(2):231-9.
1998: Tanaka S S; Togooka Y; Sato H; Seiki M; Tojo H; Tachi C
Expression and localization of membrane type matrix metalloproteinase-1 (MT1-MMP) in trophoblast cells of cultured mouse blastocysts and ectoplacental cones.
Placenta 1998;19(1):41-8.
1998: Imamura T; Ohshio G; Mise M; Harada T; Suwa H; Okada N; Wang Z; Yoshitomi S; Tanaka T; Sato H; Arii S; Seiki M; Imamura M
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Journal of cancer research and clinical oncology 1998;124(2):65-72.
1997: Imai K; Ohta S; Matsumoto T; Fujimoto N; Sato H; Seiki M; Okada Y
Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage.
The American journal of pathology 1997;151(1):245-56.
1997: Sato H; Okada Y; Seiki M
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
Thrombosis and haemostasis 1997;78(1):497-500.
1997: Tanaka S S; Mariko Y; Mori H; Ishijima J; Tachi S; Sato H; Seiki M; Yamanouchi K; Tojo H; Tachi C
Cell-cell contact down-regulates expression of membrane type metalloproteinase-1 (MT1-MMP) in a mouse mammary gland epithelial cell line.
Zoological science 1997;14(1):95-9.
1997: Tanaka M; Sato H; Takino T; Iwata K; Inoue M; Seiki M
Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product.
FEBS letters 1997;402(2-3):219-22.
1997: Ohuchi E; Imai K; Fujii Y; Sato H; Seiki M; Okada Y
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.
The Journal of biological chemistry 1997;272(4):2446-51.
1997: Yoshizaki T; Sato H; Maruyama Y; Murono S; Furukawa M; Park C S; Seiki M
Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma.
Cancer 1997;79(1):139-44.
1996: Sato H; Kinoshita T; Takino T; Nakayama K; Seiki M
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2.
FEBS letters 1996;393(1):101-4.
1996: Imai K; Ohuchi E; Aoki T; Nomura H; Fujii Y; Sato H; Seiki M; Okada Y
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.
Cancer research 1996;56(12):2707-10.
1996: Kinoshita T; Sato H; Takino T; Itoh M; Akizawa T; Seiki M
Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.
Cancer research 1996;56(11):2535-8.
1996: Fujii M; Minamino T; Nomura M; Miyamoto K I; Tanaka J; Seiki M
Selective activation of the proto-oncogene c-jun promoter by the transforming protein v-Rel.
Oncogene 1996;12(10):2193-202.
1996: Sato H; Takino T; Kinoshita T; Imai K; Okada Y; Stetler Stevenson W G; Seiki M
Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP).
FEBS letters 1996;385(3):238-40.
1996: Tatsuka M; Ota T; Yamagishi N; Kashihara Y; Wada M; Matsuda N; Mitsui H; Seiki M; Odashima S
Different metastatic potentials of ras- and src-transformed BALB/c 3T3 A31 variant cells.
Molecular carcinogenesis 1996;15(4):300-8.
1996: Watanabe M; Takahashi Y; Ohta T; Mai M; Sasaki T; Seiki M
Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice.
Cancer 1996;77(8 Suppl):1676-80.
1996: Sato H; Seiki M
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.
Journal of biochemistry 1996;119(2):209-15.
1996: Nomura H; Fujimoto N; Seiki M; Mai M; Okada Y
Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas.
International journal of cancer. Journal international du cancer 1996;69(1):9-16.
1996: Seiki M
Membrane type-matrix metalloproteinase and tumor invasion.
Current topics in microbiology and immunology 1996;213 ( Pt 1)():23-32.
1995: Takino T; Sato H; Shinagawa A; Seiki M
Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family.
The Journal of biological chemistry 1995;270(39):23013-20.
1995: Nomura H; Sato H; Seiki M; Mai M; Okada Y
Expression of membrane-type matrix metalloproteinase in human gastric carcinomas.
Cancer research 1995;55(15):3263-6.
1995: Takino T; Sato H; Seiki M
[Molecular biology of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), and the regulation of these genes in tumor tissues]
Nippon rinsho. Japanese journal of clinical medicine 1995;53(7):1791-7.
1995: Fujii M; Chuhjo T; Minamino T; Masaaki N; Miyamoto K; Seiki M
Identification of the Tax interaction region of serum response factor that mediates the aberrant induction of immediate early genes through CArG boxes by HTLV-I Tax.
Oncogene 1995;11(1):7-14.
1995: Cao J; Sato H; Takino T; Seiki M
The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation.
The Journal of biological chemistry 1995;270(2):801-5.
1995: Fujii M; Tsuchiya H; Meng X B; Seiki M
c-Jun, c-Fos and their family members activate the transcription mediated by three 21-bp repetitive sequences in the HTLV-I long terminal repeat.
Intervirology 1995;38(3-4):221-8.
1994: Fujii M; Tsuchiya H; Chuhjo T; Minamino T; Miyamoto K; Seiki M
Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.
Journal of virology 1994;68(11):7275-83.
1994: Sato H; Takino T; Okada Y; Cao J; Shinagawa A; Yamamoto E; Seiki M
A matrix metalloproteinase expressed on the surface of invasive tumour cells.
Nature 1994;370(6484):61-5.
1994: Uchijima M; Sato H; Fujii M; Seiki M
Tax proteins of human T-cell leukemia virus type 1 and 2 induce expression of the gene encoding erythroid-potentiating activity (tissue inhibitor of metalloproteinases-1, TIMP-1).
The Journal of biological chemistry 1994;269(21):14946-50.
1994: Tsuchiya H; Fujii M; Tanaka Y; Tozawa H; Seiki M
Two distinct regions form a functional activation domain of the HTLV-1 trans-activator Tax1.
Oncogene 1994;9(1):337-40.
1994: Yoshizaki T; Takimoto T; Takeshita H; Tanaka S; Furukawa M; Seiki M; Sato H
Epstein-Barr virus lytic cycle spreads via cell fusion in a nasopharyngeal carcinoma hybrid cell line.
The Laryngoscope 1994;104(1 Pt 1):91-4.
1993: Tsuchiya H; Fujii M; Niki T; Tokuhara M; Matsui M; Seiki M
Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals.
Journal of virology 1993;67(12):7001-7.
1993: Sato H; Kita M; Seiki M
v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.
The Journal of biological chemistry 1993;268(31):23460-8.
1993: Tsuchiya Y; Sato H; Endo Y; Okada Y; Mai M; Sasaki T; Seiki M
Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.
Cancer research 1993;53(6):1397-402.
1993: Seiki M
[Expression of matrix metalloproteinases in tumor cells]
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(3):387-92.
1993: Sato H; Seiki M
Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.
Oncogene 1993;8(2):395-405.
1992: Fujii M; Tsuchiya H; Chuhjo T; Akizawa T; Seiki M
Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.
Genes & development 1992;6(11):2066-76.
1992: Sato H; Takeshita H; Furukawa M; Seiki M
Epstein-Barr virus BZLF1 transactivator is a negative regulator of Jun.
Journal of virology 1992;66(8):4732-6.
1992: Endo Y; Seiki M; Uchida H; Noguchi M; Kida Y; Sato H; Mai M; Sasaki T
Experimental metastasis of oncogene-transformed NIH 3T3 cells in chick embryo.
Japanese journal of cancer research : Gann 1992;83(3):274-80.
1992: Sato H; Kida Y; Mai M; Endo Y; Sasaki T; Tanaka J; Seiki M
Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.
Oncogene 1992;7(1):77-83.
1991: Seiki M; Sato H; Liotta L A; Schiffmann E
Comparison of autocrine mechanisms promoting motility in two metastatic cell lines: human melanoma and ras-transfected NIH3T3 cells.
International journal of cancer. Journal international du cancer 1991;49(5):717-20.
1990: Okada Y; Tsuchiya H; Shimizu H; Tomita K; Nakanishi I; Sato H; Seiki M; Yamashita K; Hayakawa T
Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor alpha.
Biochemical and biophysical research communications 1990;171(2):610-7.
1989: Seiki M
[Regulation of HTLV-1 gene expression and its relevance to proliferation of the infected cells]
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):516-21.

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