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Michael Blanton

Research Profile

Chemicals & Drugs

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Torpedo

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Jonathan M Labriola; Akash Pandhare; Michael P Blanton; Pierre-Jean Corringer; Michaela Jansen; John E Baenziger
Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment.
Akash Pandhare; Brandon Staggs; Shaili Aggarwal; jonathan cohen; Phaneendra K Duddempudi; Ayman K Hamouda; Michaela Jansen; David J Lapinsky; John R Lever; Michael P Blanton
Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72.
Corrie J B daCosta; R Michel Sturgeon; Ayman K Hamouda; Michael P Blanton; John E Baenziger
Structural characterization and agonist binding to human α4β2 nicotinic receptors.

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All Publications

2013: Jonathan M Labriola; Akash Pandhare; Michael P Blanton; Pierre-Jean Corringer; Michaela Jansen; John E Baenziger
Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment.
The Journal of biological chemistry 2013;288(16):11294-303.
2012: Akash Pandhare; Brandon Staggs; Shaili Aggarwal; jonathan cohen; Phaneendra K Duddempudi; Ayman K Hamouda; Michaela Jansen; David J Lapinsky; John R Lever; Michael P Blanton
Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72.
Biochemistry 2012;51(12):2425-35.
2011: Corrie J B daCosta; R Michel Sturgeon; Ayman K Hamouda; Michael P Blanton; John E Baenziger
Structural characterization and agonist binding to human α4β2 nicotinic receptors.
Biochemical and biophysical research communications 2011;407(3):456-60.
2009: Mitesh Sanghvi; Ayman K Hamouda; Margaret I Davis; Russell A Morton; Shouryadeep Srivastava; Akash Pandhare; Phaneendra K Duddempudi; Tina K Machu; David M Lovinger; jonathan cohen; Michael P Blanton
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor.
Biochemistry 2009;48(39):9278-86.
2009: Shouryadeep Srivastava; Ayman K Hamouda; Akash Pandhare; Phaneendra K Duddempudi; Mitesh Sanghvi; jonathan cohen; Michael P Blanton
[(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors.
The Journal of biological chemistry 2009;284(37):24939-47.
2009: Ayman K Hamouda; Xiaochun Jin; Mitesh Sanghvi; Shouryadeep Srivastava; Akash Pandhare; Phaneendra K Duddempudi; Joe Henry Steinbach; Michael P Blanton
Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380.
Biochimica et biophysica acta 2009;1788(9):1987-95.
2009: Hugo R Arias; H Xing; K Macdougall; Michael P Blanton; F Soti; William R Kem
Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors.
British journal of pharmacology 2009;157(2):320-30.
2008: Mitesh Sanghvi; Ayman K Hamouda; Krzysztof Jozwiak; Michael P Blanton; James R Trudell; Hugo R Arias
Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies.
Biochimica et biophysica acta 2008;1778(12):2690-9.
2007: Ayman K Hamouda; Mitesh Sanghvi; David C Chiara; jonathan cohen; Michael P Blanton
Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine.
Biochemistry 2007;46(48):13837-46.
2006: Ayman K Hamouda; Mitesh Sanghvi; Daniel Sauls; Tina K Machu; Michael P Blanton
Assessing the lipid requirements of the Torpedo californica nicotinic acetylcholine receptor.
Biochemistry 2006;45(13):4327-37.
2006: Ayman K Hamouda; David C Chiara; Daniel Sauls; jonathan cohen; Michael P Blanton
Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol.
Biochemistry 2006;45(3):976-86.
2003: Hugo R Arias; James R Trudell; Erin Z Bayer; Brent Hester; Elizabeth A McCardy; Michael P Blanton
Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives.
Biochemistry 2003;42(24):7358-70.
2003: Hugo R Arias; William R Kem; James R Trudell; Michael P Blanton
Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor.
International review of neurobiology 2003;54():1-50.
2002: Hugo R Arias; Michael P Blanton
Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.
Mini reviews in medicinal chemistry 2002;2(4):385-410.
2002: Hugo R Arias; Elizabeth A McCardy; Erin Z Bayer; Martin J Gallagher; Michael P Blanton
Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel.
Archives of biochemistry and biophysics 2002;403(1):121-31.
2002: Corrie J B daCosta; Andrei A Ogrel; Elizabeth A McCardy; Michael P Blanton; John E Baenziger
Lipid-protein interactions at the nicotinic acetylcholine receptor. A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers.
The Journal of biological chemistry 2002;277(1):201-8.
2001: Hugo R Arias; Elizabeth A McCardy; Martin J Gallagher; Michael P Blanton
Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel.
Molecular pharmacology 2001;60(3):497-506.
2001: N Méthot; B D Ritchie; Michael P Blanton; John E Baenziger
Structure of the pore-forming transmembrane domain of a ligand-gated ion channel.
The Journal of biological chemistry 2001;276(26):23726-32.
2001: Michael P Blanton; A K Lala; jonathan cohen
Identification and characterization of membrane-associated polypeptides in Torpedo nicotinic acetylcholine receptor-rich membranes by hydrophobic photolabeling.
Biochimica et biophysica acta 2001;1512(2):215-24.
2001: Hugo R Arias; Elizabeth A McCardy; Michael P Blanton
Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor.
Molecular pharmacology 2001;59(5):1051-60.
2001: Stephen E Ryan; Michael P Blanton; John E Baenziger
A conformational intermediate between the resting and desensitized states of the nicotinic acetylcholine receptor.
The Journal of biological chemistry 2001;276(7):4796-803.
2000: Michael P Blanton; Elizabeth A McCardy
Identifying the lipid-protein interface and transmembrane structural transitions of the Torpedo Na,K-ATPase using hydrophobic photoreactive probes.
Biochemistry 2000;39(44):13534-44.
2000: Hugo R Arias; Michael P Blanton
Alpha-conotoxins.
The international journal of biochemistry & cell biology 2000;32(10):1017-28.
2000: Michael P Blanton; Elizabeth A McCardy; John D Fryer; M Liu; Ronald J. Lukas
5-hydroxytryptamine interaction with the nicotinic acetylcholine receptor.
European journal of pharmacology 2000;389(2-3):155-63.
2000: Michael P Blanton; Elizabeth A McCardy; Martin J Gallagher
Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state.
The Journal of biological chemistry 2000;275(5):3469-78.
1999: H Sun; Elizabeth A McCardy; Tina K Machu; Michael P Blanton
Characterization of interaction of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester with Torpedo californica nicotinic acetylcholine receptor and 5-hydroxytryptamine3 receptor.
The Journal of pharmacology and experimental therapeutics 1999;290(1):129-35.
1999: Michael P Blanton; Y Xie; Lawrence J Dangott; jonathan cohen
The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface.
Molecular pharmacology 1999;55(2):269-78.
1998: J Corbin; H H Wang; Michael P Blanton
Identifying the cholesterol binding domain in the nicotinic acetylcholine receptor with [125I]azido-cholesterol.
Biochimica et biophysica acta 1998;1414(1-2):65-74.
1998: Michael P Blanton; Elizabeth A McCardy; A Huggins; D Parikh
Probing the structure of the nicotinic acetylcholine receptor with the hydrophobic photoreactive probes [125I]TID-BE and [125I]TIDPC/16.
Biochemistry 1998;37(41):14545-55.
1998: Michael P Blanton; Lawrence J Dangott; S K Raja; A K Lala; jonathan cohen
Probing the structure of the nicotinic acetylcholine receptor ion channel with the uncharged photoactivable compound -3H-diazofluorene.
The Journal of biological chemistry 1998;273(15):8659-68.
1998: J Corbin; N Méthot; H H Wang; John E Baenziger; Michael P Blanton
Secondary structure analysis of individual transmembrane segments of the nicotinic acetylcholine receptor by circular dichroism and Fourier transform infrared spectroscopy.
The Journal of biological chemistry 1998;273(2):771-7.
1994: Michael P Blanton; Yueming Li; Evelyn R Stimson; John E Maggio; jonathan cohen
Agonist-induced photoincorporation of a p-benzoylphenylalanine derivative of substance P into membrane-spanning region 2 of the Torpedo nicotinic acetylcholine receptor delta subunit.
Molecular pharmacology 1994;46(6):1048-55.
1994: Michael P Blanton; jonathan cohen
Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications.
Biochemistry 1994;33(10):2859-72.
1991: Michael P Blanton; H H Wang
Localization of regions of the Torpedo californica nicotinic acetylcholine receptor labeled with an aryl azide derivative of phosphatidylserine.
Biochimica et biophysica acta 1991;1067(1):1-8.
1990: Michael P Blanton; H H Wang
Photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor with an aryl azide derivative of phosphatidylserine.
Biochemistry 1990;29(5):1186-94.
1988: Michael P Blanton; E McCardy; T Gallaher; H H Wang
Noncompetitive inhibitors reach their binding site in the acetylcholine receptor by two different paths.
Molecular pharmacology 1988;33(6):634-42.