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Yutaka Seino

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Shin-ichi Harashima; Shimpei Fujimoto; Toru Fukushima; Akihiro Hamasaki; Norio Harada; Kazuaki Nagashima; Yuko Nakahigashi; Yuichi Nishi; Masahito Ogura; Mayumi Sasaki; Yutaka Seino; Daisuke Tanaka; Shunsuke Yamane; Nobuya Inagaki
Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study).
Shin-ichi Harashima; Takahiko Horiuchi; Yutaka Seino; Yu Wang; Nobuya Inagaki
Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release.
Eiichi Ogawa; Masaya Hosokawa; Norio Harada; Shunsuke Yamane; Akihiro Hamasaki; Kentaro Toyoda; Shimpei Fujimoto; Yoshihito Fujita; Kazuhito Fukuda; Katsushi Tsukiyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.

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All Publications

2013: Shin-ichi Harashima; Shimpei Fujimoto; Toru Fukushima; Akihiro Hamasaki; Norio Harada; Kazuaki Nagashima; Yuko Nakahigashi; Yuichi Nishi; Masahito Ogura; Mayumi Sasaki; Yutaka Seino; Daisuke Tanaka; Shunsuke Yamane; Nobuya Inagaki
Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study).
Diabetes/metabolism research and reviews 2013;29(1):77-84.
2011: Shin-ichi Harashima; Takahiko Horiuchi; Yutaka Seino; Yu Wang; Nobuya Inagaki
Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release.
Journal of neuroscience research 2011;89(10):1519-30.
2011: Eiichi Ogawa; Masaya Hosokawa; Norio Harada; Shunsuke Yamane; Akihiro Hamasaki; Kentaro Toyoda; Shimpei Fujimoto; Yoshihito Fujita; Kazuhito Fukuda; Katsushi Tsukiyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.
Biochemical and biophysical research communications 2011;404(1):115-20.
2010: Shimpei Fujimoto; Nobuya Inagaki; Yutaka Seino
[Pancreatic polypeptide (PP)].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 7():560-2.
2010: Y Fujita; M Hosokawa; Shimpei Fujimoto; Eri Mukai; A Abudukadier; A Obara; M Ogura; Yasuyuki Nakamura; K Toyoda; K Nagashima; Yutaka Seino; Nobuya Inagaki
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice.
Diabetologia 2010;53(7):1472-81.
2010: Yukiko Kawasaki; S Harashima; M Sasaki; Eri Mukai; Yoshio Nakamura; Norio Harada; Kentaro Toyoda; Akihiro Hamasaki; S Yamane; Chizumi Yamada; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2010;42(5):311-7.
2010: Makiko Shimodahira; Shimpei Fujimoto; Eri Mukai; Yasuhiko Nakamura; Yuichi Nishi; Mayumi Sasaki; Yuichi Sato; Hiroki Sato; Masaya Hosokawa; Kazuaki Nagashima; Yutaka Seino; Nobuya Inagaki
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism.
The Journal of endocrinology 2010;204(1):37-46.
2009: Xibao Liu; Norio Harada; Shunsuke Yamane; Lisa Kitajima; Saeko Uchida; Akihiro Hamasaki; Eri Mukai; Kentaro Toyoda; Chizumi Yamada; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice.
Life sciences 2009;84(25-26):876-81.
2008: Shogo Funakoshi; Shimpei Fujimoto; Akihiro Hamasaki; Hideya Fujiwara; Yoshihito Fujita; Kaori Ikeda; Yoshiyuki Hamamoto; Masaya Hosokawa; Yutaka Seino; Nobuya Inagaki
Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure.
Diabetes research and clinical practice 2008;82(3):353-8.
2008: Rei Naitoh; Kazumasa Miyawaki; Norio Harada; Wataru Mizunoya; Kentaro Toyoda; Tohru Fushiki; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice.
Biochemical and biophysical research communications 2008;376(1):21-5.
2008: Yabe Daisuke; Akira Kuroe; Michihiro Ohya; Koin Watanabe; Naomi Kitatani; Masayuki Oku; Takeshi Kurose; Yutaka Seino
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion.
Diabetes research and clinical practice 2008;82(2):e1-4.
2008: Norio Harada; Mitsuo Fukushima; Kentaro Toyoda; Ryoji Mitsui; Tomoyo Izuka; Ataru Taniguchi; Yoshikatsu Nakai; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Factors responsible for elevation of 1-h postchallenge plasma glucose levels in Japanese men.
Diabetes research and clinical practice 2008;81(3):284-9.
2008: Mariko Sassa; Yuichiro Yamada; Masaya Hosokawa; Kazuhito Fukuda; Shimpei Fujimoto; Kentaro Toyoda; Katsushi Tsukiyama; Yutaka Seino; Nobuya Inagaki
Glycemic instability in type 1 diabetic patients: Possible role of ketosis or ketoacidosis at onset of diabetes.
Diabetes research and clinical practice 2008;81(2):190-5.
2008: Rieko Kominato; Shimpei Fujimoto; Eri Mukai; Yasuyuki Nakamura; Koichiro Nabe; Makiko Shimodahira; Yuichi Nishi; Shogo Funakoshi; Yutaka Seino; Nobuya Inagaki
Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets.
Diabetologia 2008;51(7):1226-35.
2008: Hideya Fujiwara; Masaya Hosokawa; Xiaorong Zhou; Shimpei Fujimoto; Kazuhito Fukuda; Kentaro Toyoda; Yuichi Nishi; Yoshihito Fujita; Kotaro Yamada; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Curcumin inhibits glucose production in isolated mice hepatocytes.
Diabetes research and clinical practice 2008;80(2):185-91.
2008: Kotaro Yamada; Masaya Hosokawa; Chizumi Yamada; Rie Watanabe; Shimpei Fujimoto; Hideya Fujiwara; Masaru Kunitomo; Toshihiro Miura; Tetsuo Kaneko; Kinsuke Tsuda; Yutaka Seino; Nobuya Inagaki
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
Biological & pharmaceutical bulletin 2008;31(4):651-5.
2008: Yoshihito Fujita; Mitsuo Fukushima; Haruhiko Suzuki; Ataru Taniguchi; Yoshikatsu Nakai; Akira Kuroe; Koichiro Yasuda; Masaya Hosokawa; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Short-term intensive glycemic control improves vibratory sensation in type 2 diabetes.
Diabetes research and clinical practice 2008;80(1):e16-9.
2008: Kotaro Yamada; Masaya Hosokawa; Shimpei Fujimoto; Hideya Fujiwara; Yoshihito Fujita; Norio Harada; Chizumi Yamada; Mitsuo Fukushima; Naoya Ueda; Tetsuo Kaneko; Futoshi Matsuyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Effect of corosolic acid on gluconeogenesis in rat liver.
Diabetes research and clinical practice 2008;80(1):48-55.
2008: Kentaro Toyoda; Teru Okitsu; Shunsuke Yamane; Taeko Uonaga; Xibao Liu; Norio Harada; Shinji Uemoto; Yutaka Seino; Nobuya Inagaki
GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis.
Biochemical and biophysical research communications 2008;367(4):793-8.
2008: Kentaro Toyoda; Mitsuo Fukushima; Ryoji Mitsui; Norio Harada; Hidehiko Suzuki; Tomomi Takeda; Ataru Taniguchi; Yoshikatsu Nakai; Toshiko Kawakita; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men.
Metabolism: clinical and experimental 2008;57(2):299-303.
2008: Chizumi Yamada; Yuichiro Yamada; Katsushi Tsukiyama; Kotaro Yamada; Nobuyuki Udagawa; Naoyuki Takahashi; Kiyoshi Tanaka; Daniel J Drucker; Yutaka Seino; Nobuya Inagaki
The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.
Endocrinology 2008;149(2):574-9.
2008: Norio Harada; Yuichiro Yamada; Katsushi Tsukiyama; Chizumi Yamada; Yasuhiko Nakamura; Eri Mukai; Akihiro Hamasaki; Xibao Liu; Kentaro Toyoda; Yutaka Seino; Nobuya Inagaki
A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E61-8.
2007: Hiroki Ikeda; Qing Yong; Takeshi Kurose; Takeshi Todo; Wataru Mizunoya; Tohru Fushiki; Yutaka Seino; Yuichiro Yamada
Clock gene defect disrupts light-dependency of autonomic nerve activity.
Biochemical and biophysical research communications 2007;364(3):457-63.
2007: Chizumi Yamada; Yuichiro Yamada; Katsushi Tsukiyama; Kotaro Yamada; Shunsuke Yamane; Norio Harada; Kazumasa Miyawaki; Yutaka Seino; Nobuya Inagaki
Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes.
Biochemical and biophysical research communications 2007;364(1):175-80.
2007: Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Akira Kuroe; Michihiro Ohya; Minako Ohgushi; Yutaka Seino
Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: association with atherosclerosis.
Diabetes research and clinical practice 2007;77 Suppl 1():S213-9.
2007: Shimpei Fujimoto; Koichiro Nabe; Mihoko Takehiro; Makiko Shimodahira; Mariko Kajikawa; Tomomi Takeda; Eri Mukai; Nobuya Inagaki; Yutaka Seino
Impaired metabolism-secretion coupling in pancreatic beta-cells: role of determinants of mitochondrial ATP production.
Diabetes research and clinical practice 2007;77 Suppl 1():S2-10.
2007: Akira Takahashi; Kazuaki Nagashima; Akihiro Hamasaki; Naomitsu Kuwamura; Yukiko Kawasaki; Hiroki Ikeda; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase.
Diabetes research and clinical practice 2007;77(3):343-50.
2007: Akira Kuroe; Ataru Taniuguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Minako Ohgushi; Michihiro Ohya; Yutaka Seino
Early and late onset side effects of short-acting insulin analogue in seven Japanese diabetic patients.
Diabetes research and clinical practice 2007;77(3):412-3.
2007: Akari Inada; Hidenori Arai; Kojiro Nagai; Jun-ichi Miyazaki; Yuichiro Yamada; Yutaka Seino; Atsushi Fukatsu
Gender difference in ICER Igamma transgenic diabetic mouse.
Bioscience, biotechnology, and biochemistry 2007;71(8):1920-6.
2007: Ataru Taniguchi; Mitsuo Fukushima; Akira Kuroe; Kenji Sakaguchi; Hiroko Hashimoto; Ikuko Yoshioka; Naomi Kitatani; Tomoko Tsuji; Michihiro Ohya; Minako Ohgushi; Shoichiro Nagasaka; Okihisa Isogai; Yoshikatsu Nakai; Nobuya Inagaki; Yutaka Seino
Metabolic syndrome, insulin resistance, and atherosclerosis in Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2007;56(8):1099-103.
2007: N Kitatani; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Shoichiro Nagasaka; Minako Ohgushi; Michihiro Ohya; Akira Kuroe; Nobuya Inagaki; Yutaka Seino
Association of serum resistin with TNF system activity in Japanese type 2 diabetic patients.
Diabetes & metabolism 2007;33(2):156-7.
2007: Minako Ohgushi; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Akira Kuroe; Michihiro Ohya; Shoichiro Nagasaka; Yoshiro Taki; Satoru Yoshii; Kazunari Matsumoto; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Soluble tumor necrosis factor receptor 2 is independently associated with pulse wave velocity in nonobese Japanese patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2007;56(4):571-7.
2007: Akihiro Hamasaki; Yuichiro Yamada; Takeshi Kurose; Nobuhiro Ban; Kazuaki Nagashima; Akira Takahashi; Shimpei Fujimoto; Dai Shimono; Michio Fujiwara; Shinya Toyokuni; Yutaka Seino; Nobuya Inagaki
Adult pancreatic islets require differential pax6 gene dosage.
Biochemical and biophysical research communications 2007;353(1):40-6.
2007: D Nabeya; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; K Matsumoto; Akira Kuroe; Minako Ohgushi; Michihiro Ohya; Shoichiro Nagasaka; Nobuya Inagaki; Yutaka Seino
Soluble vascular cell adhesion molecule-1 is independently associated with soluble tumor necrosis factor receptor 2 in Japanese type 2 diabetic patients.
Diabetes & metabolism 2007;33(1):81-2.
2007: Kotaro Yamada; Masaya Hosokawa; Shimpei Fujimoto; Kazuaki Nagashima; Kazuhito Fukuda; Hideya Fujiwara; Eiichi Ogawa; Yoshihito Fujita; Naoya Ueda; Futoshi Matsuyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
The spontaneously diabetic Torii rat with gastroenteropathy.
Diabetes research and clinical practice 2007;75(2):127-34.
2007: Takiko Yanagawa; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Shoichiro Nagasaka; Minako Ohgushi; Kazunari Matsumoto; Akira Kuroe; Michihiro Ohya; Yutaka Seino
Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients.
Diabetes research and clinical practice 2007;75(1):2-6.
2006: Chizumi Yamada; Kazuaki Nagashima; Akira Takahashi; Hiroyuki Ueno; Yukiko Kawasaki; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis.
European journal of pharmacology 2006;553(1-3):67-72.
2006: Yuichiro Yamada; Kazuhito Fukuda; Shimpei Fujimoto; Masaya Hosokawa; Katsushi Tsukiyama; Kazuaki Nagashima; Mitsuo Fukushima; Haruhiko Suzuki; Kentaro Toyoda; Mariko Sassa; Shogo Funakoshi; Nobuya Inagaki; Ataru Taniguchi; T Shun Sato; Shinichi Matsumoto; Koichi Tanaka; Yutaka Seino
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes.
Diabetes research and clinical practice 2006;74(3):222-6.
2006: Y Nomura; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Fusanori Nishimura; Akira Kuroe; Minako Ohgushi; Michihiro Ohya; Y Murayama; Yutaka Seino
Soluble TNF receptor and periodontal disease in non-obese Japanese type 2 diabetic patients.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(10):688-9.
2006: Mariko Sassa; Kazuhito Fukuda; Shimpei Fujimoto; Kentaro Toyoda; Yoshihito Fujita; Shinichi Matsumoto; Teru Okitsu; Yasuhiro Iwanaga; Hirofumi Noguchi; Hideo Nagata; Yukihide Yonekawa; Takeshi Ohara; Masahiko Okamoto; Koichi Tanaka; Yutaka Seino; Nobuya Inagaki; Yuichiro Yamada
A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.
Diabetes research and clinical practice 2006;73(3):235-40.
2006: Fusanori Nishimura; Ataru Taniguchi; M Yamaguchi-Morimoto; Yoshihiko Soga; Yoshihiro Iwamoto; Susumu Kokeguchi; Akira Kuroe; Mitsuo Fukushima; Yoshikatsu Nakai; Yutaka Seino
Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(8):530-5.
2006: Mitsuo Fukushima; F Matsuyama; Naoya Ueda; K Egawa; J Takemoto; Y Kajimoto; N Yonaha; T Miura; T Kaneko; Yuichi Nishi; Ryoji Mitsui; Yoshihito Fujita; Yuichiro Yamada; Yutaka Seino
Effect of corosolic acid on postchallenge plasma glucose levels.
Diabetes research and clinical practice 2006;73(2):174-7.
2006: Katsushi Tsukiyama; Yuichiro Yamada; Chizumi Yamada; Norio Harada; Yukiko Kawasaki; Masahito Ogura; Kazuhisa Bessho; Minqi Li; Norio Amizuka; Masahiro Sato; Nobuyuki Udagawa; Naoyuki Takahashi; Kiyoshi Tanaka; Yutaka Oiso; Yutaka Seino
Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1644-51.
2006: Minako Ohgushi; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Akira Kuroe; Michihiro Ohya; Yutaka Seino
Soluble tumor necrosis factor receptor 2 is independently associated with brachial-ankle pulse-wave velocity in nonobese Japanese type 2 diabetic patients.
Diabetes care 2006;29(6):1459-60.
2006: Koichiro Nabe; Shimpei Fujimoto; Makiko Shimodahira; Rieko Kominato; Yuichi Nishi; Shogo Funakoshi; Eri Mukai; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic H+ concentration in pancreatic islets.
Endocrinology 2006;147(6):2717-27.
2006: Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Minako Ohgushi; Akira Kuroe; Michihiro Ohya; Yutaka Seino
Soluble tumor necrosis factor receptor 1 is strongly and independently associated with serum homocysteine in nonobese Japanese type 2 diabetic patients.
Diabetes care 2006;29(4):949-50.
2006: Ataru Taniguchi; Mitsuo Fukushima; Michihiro Ohya; Yoshikatsu Nakai; Satoru Yoshii; Shoichiro Nagasaka; Kazunari Matsumoto; Yoshiro Taki; Akira Kuroe; Fusanori Nishimura; Yutaka Seino
Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2006;55(2):258-62.
2006: Ryoji Mitsui; Mitsuo Fukushima; Yuichi Nishi; Naoya Ueda; Haruhiko Suzuki; Ataru Taniguchi; Yoshikatsu Nakai; Toshiko Kawakita; Takeshi Kurose; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men.
Metabolism: clinical and experimental 2006;55(1):53-8.
2005: Hidehiko Suzuki; Mitsuo Fukushima; Shigeru Okamoto; Osamu Takahashi; Takuro Shimbo; Takeshi Kurose; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino; Tsuguya Fukui
Effects of thorough mastication on postprandial plasma glucose concentrations in nonobese Japanese subjects.
Metabolism: clinical and experimental 2005;54(12):1593-9.
2005: Y Kawasaki; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Akira Kuroe; Michihiro Ohya; Shoichiro Nagasaka; Yuichiro Yamada; Nobuya Inagaki; Yutaka Seino
Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(10):617-21.
2005: Michihiro Ohya; Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Yukiko Kawasaki; Shoichiro Nagasaka; Akira Kuroe; Yoshiro Taki; Satoru Yoshii; Masaya Hosokawa; Nobuya Inagaki; Yutaka Seino
Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2005;54(10):1297-301.
2005: Yuichi Nishi; Mitsuo Fukushima; Haruhiko Suzuki; Ryoji Mitsui; Naoya Ueda; Ataru Taniguchi; Yoshikatsu Nakai; Toshiko Kawakita; Takeshi Kurose; Yutaka Seino; Yuichiro Yamada
Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia.
Diabetes research and clinical practice 2005;70(1):46-52.
2005: Heying Zhou; Yuichiro Yamada; Katsushi Tsukiyama; Kazumasa Miyawaki; Masaya Hosokawa; Kazuaki Nagashima; Kentaro Toyoda; Rei Naitoh; Wataru Mizunoya; Tohru Fushiki; Takashi Kadowaki; Yutaka Seino
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.
Biochemical and biophysical research communications 2005;335(3):937-42.
2005: Dai Shimono; Shimpei Fujimoto; Eri Mukai; Mihoko Takehiro; Koichiro Nabe; Razvan Gheorghe Radu; Makiko Shimodahira; Rieko Kominato; Yo Aramaki; Yuichi Nishi; Shogo Funakoshi; Yuichiro Yamada; Yutaka Seino
ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca2+-depleted condition.
Diabetes research and clinical practice 2005;69(3):216-23.
2005: Kazuhito Fukuda; Nobuya Inagaki; Yutaka Seino
[Pancreatic polypeptide].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():521-3.
2005: Akari Inada; Kojiro Nagai; Hidenori Arai; Jun-ichi Miyazaki; Keiko Nomura; Hiroshi Kanamori; Shinya Toyokuni; Yuichiro Yamada; Susan Bonner-Weir; Gordon C Weir; Atsushi Fukatsu; Yutaka Seino
Establishment of a diabetic mouse model with progressive diabetic nephropathy.
The American journal of pathology 2005;167(2):327-36.
2005: Hiroyuki Ueno; Yuichiro Yamada; Rie Watanabe; Eri Mukai; Masaya Hosokawa; Akira Takahashi; Akihiro Hamasaki; Hideya Fujiwara; Shinya Toyokuni; Masahiro Yamaguchi; Jun Takeda; Yutaka Seino
Nestin-positive cells in adult pancreas express amylase and endocrine precursor Cells.
Pancreas 2005;31(2):126-31.
2005: Ataru Taniguchi; Mitsuo Fukushima; Yoshikatsu Nakai; Akira Kuroe; Gen Yamano; Takiko Yanagawa; Minako Ohgushi; Michihiro Ohya; Satoru Yoshii; Yoshiro Taki; Yutaka Seino
Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2005;54(3):376-80.
2005: Masahito Ogura; Yutaka Seino
[Diet therapy for impaired glucose tolerance].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():503-8.
2005: Yuichi Nishi; Yuichiro Yamada; Mitsuo Fukushima; Yutaka Seino
[Insulin secretion and insulin sensitivity in subjects with impaired fasting glucose].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():151-4.
2005: Mihoko Takehiro; Shimpei Fujimoto; Makiko Shimodahira; Dai Shimono; Eri Mukai; Koichiro Nabe; Razvan Gheorghe Radu; Rieko Kominato; Yo Aramaki; Yutaka Seino; Yuichiro Yamada
Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E372-80.
2005: Razvan Gheorghe Radu; Shimpei Fujimoto; Eri Mukai; Mihoko Takehiro; Dai Shimono; Koichiro Nabe; Makiko Shimodahira; Rieko Kominato; Yo Aramaki; Yuichi Nishi; Shogo Funakoshi; Yuichiro Yamada; Yutaka Seino
Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E365-71.
2004: Kazuaki Nagashima; Akira Takahashi; Hiroki Ikeda; Akihiro Hamasaki; Naomitsu Kuwamura; Yuichiro Yamada; Yutaka Seino
Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity.
Diabetes research and clinical practice 2004;66 Suppl 1():S75-8.
2004: Mitsuo Fukushima; Haruhiko Suzuki; Yutaka Seino
Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes.
Diabetes research and clinical practice 2004;66 Suppl 1():S37-43.
2004: Yuichiro Yamada; Yutaka Seino
Physiology of GIP--a lesson from GIP receptor knockout mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2004;36(11-12):771-4.
2004: Eri Mukai; Noriaki Kume; Kazutaka Hayashida; Manabu Minami; Yuichiro Yamada; Yutaka Seino; Toru Kita
Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells.
Atherosclerosis 2004;176(2):289-96.
2004: Katsushi Tsukiyama; Yuichiro Yamada; Kazumasa Miyawaki; Akihiro Hamasaki; Kazuaki Nagashima; Masaya Hosokawa; Shimpei Fujimoto; Akira Takahashi; Kentaro Toyoda; Shinya Toyokuni; Yutaka Oiso; Yutaka Seino
Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(3):407-12.
2004: Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Yoshikatsu Nakai; Ataru Taniguchi; Toshifumi Matsuura; Hidehiko Suzuki; Takeshi Kurose; Yuichiro Yamada; Yutaka Seino
Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes.
Metabolism: clinical and experimental 2004;53(7):831-5.
2004: Haruhiko Suzuki; Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Ataru Taniguchi; Yoshikatsu Nakai; Toshifumi Matsuura; Koichiro Yasuda; Masaya Hosokawa; Yutaka Seino; Yuichiro Yamada
IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.
Diabetes research and clinical practice 2004;64(3):213-9.
2004: Akari Inada; Yoshiyuki Hamamoto; Yoshiyuki Tsuura; Jun-ichi Miyazaki; Shinya Toyokuni; Yu Ihara; Koichiro Nagai; Yuichiro Yamada; Susan Bonner-Weir; Yutaka Seino
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells.
Molecular and cellular biology 2004;24(7):2831-41.
2004: Hiroyuki Koshiyama; Kiyoshi Tanaka; Yutaka Seino
[Obesity and bone metabolism].
Clinical calcium 2004;14(2):248-54.
2004: Akira Kuroe; Ataru Taniguchi; A Sekiguchi; Masahito Ogura; Yoji Murayama; Fusanori Nishimura; Yoshihiro Iwamoto; Yutaka Seino; Shoichiro Nagasaka; Mitsuo Fukushima; Yoshihiko Soga; Yoshikatsu Nakai
Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: relationship with C-reactive protein and albuminuria.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2004;36(2):116-8.
2003: M Oya; Masaya Hosokawa; H Tsukada; Kazuhito Fukuda; H Nakamura; Katsushi Tsukiyama; Kazuaki Nagashima; Shimpei Fujimoto; Yuichiro Yamada; Yutaka Seino
Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Diabetes research and clinical practice 2003;62(2):69-77.
2003: Ataru Taniguchi; Mitsuo Fukushima; Yutaka Seino; Masahiko Sakai; Satoru Yoshii; Shoichiro Nagasaka; Ichizoh Yamauchi; Takahide Okumura; Kazuko Nin; Kumpei Tokuyama; Noriko Yamadori; Masahito Ogura; Akira Kuroe; Yoshikatsu Nakai
Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2003;52(10):1246-9.
2003: Yoshiyuki Hamamoto; Shimpei Fujimoto; Akari Inada; Mihoko Takehiro; Koichiro Nabe; Dai Shimono; Mariko Kajikawa; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(8):460-5.
2003: Fumiaki Sugawara; Yuichiro Yamada; Rie Watanabe; Nobuhiro Ban; Kazumasa Miyawaki; Akira Kuroe; Akihiro Hamasaki; Hiroki Ikeda; Takeshi Kurose; Masaru Usami; Masaki Ikeda; Yutaka Seino
The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.
Diabetes research and clinical practice 2003;60(3):191-7.
2003: Haruhiko Suzuki; Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Ataru Taniguchi; Yosikatsu Nakai; Toshifumi Matsuura; Akira Kuroe; Koichiro Yasuda; Takeshi Kurose; Yutaka Seino; Yuichiro Yamada
Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia.
Diabetes care 2003;26(4):1211-5.
2003: Shimpei Fujimoto; Aki Matsushima; Kazuyasu Yoshitani; Michihiro Oya; Dai Shimono; Tomomi Takeda; Takeshi Kurose; Yuichiro Yamada; Yutaka Seino
Type-1 diabetes mellitus with insufficient serum immunoreactive insulin elevation after subcutaneous NPH-insulin injection.
Diabetes research and clinical practice 2003;60(1):69-73.
2003: Naoko Suzuki; Tetsuro Matsunaga; Kae Nagasumi; Tsubasa Yamamura; Nobuyuki Shihara; Toshio Moritani; Hidetoshi Ue; Mitsuo Fukushima; Akiko Tamon; Yutaka Seino; Kinsuke Tsuda; Koichiro Yasuda
Alpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese.
The Journal of clinical endocrinology and metabolism 2003;88(3):1184-7.
2003: Ataru Taniguchi; Fusanori Nishimura; Yoji Murayama; Shoichiro Nagasaka; Mitsuo Fukushima; Masahiko Sakai; Satoru Yoshii; Akira Kuroe; Haruhiko Suzuki; Yoshihiro Iwamoto; Yoshihiko Soga; Takahide Okumura; Masahito Ogura; Yuichiro Yamada; Yutaka Seino; Yoshikatsu Nakai
Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2003;52(2):142-5.
2003: Koichiro Yasuda; K Shimowada; Mika Uno; H Odaka; Tetsuya Adachi; Nobuyuki Shihara; Naoko Suzuki; Akiko Tamon; Kazuaki Nagashima; Masaya Hosokawa; Kinsuke Tsuda; Yutaka Seino
Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats.
Diabetes research and clinical practice 2003;59(2):113-22.
2003: Akira Kuroe; Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Yoshikatsu Nakai; Ataru Taniguchi; Toshifumi Matsuura; Haruhiko Suzuki; Takeshi Kurose; Koichiro Yasuda; Yuichiro Yamada; Yutaka Seino
Impaired beta-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance.
Diabetes research and clinical practice 2003;59(1):71-7.
2002: Ataru Taniguchi; Shoichiro Nagasaka; Mitsuo Fukushima; Masahiko Sakai; Takahide Okumura; Satoru Yoshii; Toshiki Watanabe; Masahito Ogura; Noriko Yamadori; Kazuko Nin; Akira Kuroe; Yuichiro Yamada; Yutaka Seino; Yoshikatsu Nakai
C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.
Metabolism: clinical and experimental 2002;51(12):1578-81.
2002: Koichiro Yasuda; Waka Nishikawa; Nobumasa Iwanaka; Eitaro Nakamura; Yutaka Seino; Kinsuke Tsuda; Akihiko Ishihara
Abnormality in fibre type distribution of soleus and plantaris muscles in non-obese diabetic Goto-Kakizaki rats.
Clinical and experimental pharmacology & physiology 2002;29(11):1001-8.
2002: Mariko Kajikawa; Shimpei Fujimoto; Yoshiyuki Tsuura; Eri Mukai; Tomomi Takeda; Yoshiyuki Hamamoto; Mihoko Takehiro; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets.
Diabetes 2002;51(8):2522-9.
2002: Koichiro Nabe; Yutaka Seino
[Hexokinase].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():542-7.
2002: Rei Naitoh; Yutaka Seino
[Oxidative stress and development of type 1 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():395-8.
2002: Kazuhito Fukuda; Yutaka Seino
[The other gastrointestinal hormones in diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():291-7.
2002: Hiroyuki Ueno; Takeshi Kurose; Yutaka Seino
[History and perspective of classification for diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():28-35.
2002: Kazuhito Fukuda; Yutaka Seino
[Gastrointestinal hormones in diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():259-64.
2002: Akari Inada; Yutaka Seino
[The regulation of insulin gene transcription by transcription factors].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():159-64.
2002: Yuichiro Yamada; Yutaka Seino
[Review: regulation of glucose metabolism].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():153-8.
2002: Kazumasa Miyawaki; Yuichiro Yamada; Nobuhiro Ban; Yu Ihara; Katsushi Tsukiyama; Heying Zhou; Shimpei Fujimoto; Akira Oku; Kinsuke Tsuda; Shinya Toyokuni; Hiroshi Hiai; Wataru Mizunoya; Tohru Fushiki; Jens Juul Holst; Mitsuhiro Makino; Akira Tashita; Yukari Kobara; Yoshiharu Tsubamoto; Takayoshi Jinnouchi; Takahito Jomori; Yutaka Seino
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Nature medicine 2002;8(7):738-42.
2002: Nobuhiro Ban; Yuichiro Yamada; Yoshimichi Someya; Kazumasa Miyawaki; Yu Ihara; Masaya Hosokawa; Shinya Toyokuni; Kinsuke Tsuda; Yutaka Seino
Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter.
Diabetes 2002;51(5):1409-18.
2002: Koichiro Yasuda; Yoshimasa Okamoto; Kumiko Nunoi; Tetsuya Adachi; Nobuyuki Shihara; Akiko Tamon; Naoko Suzuki; Eri Mukai; Shimpei Fujimoto; Akira Oku; Kinsuke Tsuda; Yutaka Seino
Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(4):217-21.
2002: Shimpei Fujimoto; Eri Mukai; Yoshiyuki Hamamoto; Tomomi Takeda; Mihoko Takehiro; Yuichiro Yamada; Yutaka Seino
Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets.
Endocrinology 2002;143(1):213-21.
2001: F Sugawara; Yuichiro Yamada; Akira Kuroe; Yoshimichi Someya; A Kubota; Yu Ihara; K Takahashi; Yutaka Seino
Human TSC-22 gene: no association with type 2 diabetes.
Internal medicine (Tokyo, Japan) 2001;40(10):993-7.
2001: Yoshiyuki Hamamoto; Yoshiyuki Tsuura; Shimpei Fujimoto; M Nagata; Tomomi Takeda; Eri Mukai; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Recovery of function and mass of endogenous beta-cells in streptozotocin-induced diabetic rats treated with islet transplantation.
Biochemical and biophysical research communications 2001;287(1):104-9.
2001: Mitsuo Fukushima; Ataru Taniguchi; Yoshikatsu Nakai; Masahiko Sakai; K Doi; Kazuko Nin; T Oguma; Shoichiro Nagasaka; Kumpei Tokuyama; Yutaka Seino
Remnant-like particle cholesterol and insulin resistance in nonobese nonhypertensive Japanese glucose-tolerant relatives of type 2 diabetic patients.
Diabetes care 2001;24(9):1691-4.
2001: ZP Shen; M Nishimura; Yoshiyuki Tsuura; Shimpei Fujimoto; Eri Mukai; Yuichiro Yamada; Yutaka Seino
Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.
Diabetes research and clinical practice 2001;53(1):9-16.
2001: Nobuyuki Shihara; Koichiro Yasuda; Toshio Moritani; Hidetoshi Ue; Mika Uno; Tetsuya Adachi; Kumiko Nunoi; Yutaka Seino; Yuichiro Yamada; Kinsuke Tsuda
Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(6):761-6.
2001: Tomomi Takeda; Yoshiyuki Tsuura; Jun Fujita; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; Yoshiyuki Hamamoto; Makoto Kume; Yoshie Yamamoto; Yoshio Yamaoka; Yuichiro Yamada; Yutaka Seino
Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets.
Biochemical and biophysical research communications 2001;284(1):20-5.
2001: Yuichiro Yamada; Akira Kuroe; Q Li; Yoshimichi Someya; A Kubota; Yu Ihara; Yoshiyuki Tsuura; Yutaka Seino
Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients.
Diabetes/metabolism research and reviews 2001;17(3):213-6.
2001: A Shiraishi; Yuichiro Yamada; Yoshiyuki Tsuura; S Fijimoto; Katsushi Tsukiyama; Eri Mukai; Y Toyoda; I Miwa; Yutaka Seino
A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activity.
The Journal of biological chemistry 2001;276(4):2325-8.
2001: Minoru Horie; N Mizuno; Keiko Tsuji; Tetsuya Haruna; Tomonori Ninomiya; H Ishida; Yutaka Seino; Shigetake Sasayama
Disopyramide and its metabolite enhance insulin release from clonal pancreatic beta-cells by blocking K(ATP) channels.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2001;15(1):31-9.
2000: Shimpei Fujimoto; Yoshiyuki Tsuura; H Ishida; K Tsuji; Eri Mukai; Mariko Kajikawa; Yoshiyuki Hamamoto; Tomomi Takeda; Yuichiro Yamada; Yutaka Seino
Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E927-40.
2000: M Onomura; H Tsukada; Kazuhiko Fukuda; M Kodama; Md. Kaimul Ahsan; Masaya Hosokawa; Michihiro Ohya; Yutaka Seino
Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis.
Journal of gastroenterology and hepatology 2000;15(8):931-8.
2000: Tetsuya Adachi; Koichiro Yasuda; Yoshimasa Okamoto; Nobuyuki Shihara; Akira Oku; Kiichiro Ueta; K Kitamura; Aya Saito; I Iwakura; Yuichiro Yamada; H Yano; Yutaka Seino; Kinsuke Tsuda
T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats.
Metabolism: clinical and experimental 2000;49(8):990-5.
2000: Nobuhiro Ban; Yuichiro Yamada; Yoshimichi Someya; Yu Ihara; Tetsuya Adachi; A Kubota; Rie Watanabe; Akira Kuroe; Akari Inada; Kazumasa Miyawaki; Yasuhiro Sunaga; ZP Shen; T Iwakura; Katsushi Tsukiyama; Shinya Toyokuni; Kinsuke Tsuda; Yutaka Seino
Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.
Diabetes 2000;49(7):1142-8.
2000: T Iwakura; Shimpei Fujimoto; S Kagimoto; Akari Inada; A Kubota; Yoshimichi Someya; Yu Ihara; Yuichiro Yamada; Yutaka Seino
Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells.
Biochemical and biophysical research communications 2000;271(2):422-8.
2000: Yu Ihara; Yuichiro Yamada; Shinya Toyokuni; Kazumasa Miyawaki; Nobuhiro Ban; Tetsuya Adachi; Akira Kuroe; T Iwakura; A Kubota; Hiroshi Hiai; Yutaka Seino
Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes.
FEBS letters 2000;473(1):24-6.
2000: K Ajiro; M Sawamura; Katsumi Ikeda; Y Nara; M Nishimura; H Ishida; Yutaka Seino; Yukio Yamori
Beneficial effects of fish oil on glucose metabolism in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 2000;27(5-6):412-5.
2000: Masaya Hosokawa; H Tsukada; F Fukuda; M Oya; M Onomura; Md. Kaimul Ahsan; M Kodama; J Fujita; Yutaka Seino
Therapeutic effect of basic fibroblast growth factor on experimental pancreatitis in rat.
Pancreas 2000;20(4):373-7.
2000: Kumiko Nunoi; Koichiro Yasuda; H Tanaka; A Kubota; Yoshimasa Okamoto; Tetsuya Adachi; Nobuyuki Shihara; Mika Uno; L M Xu; S Kagimoto; Yutaka Seino; Yuichiro Yamada; Kinsuke Tsuda
Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway.
Biochemical and biophysical research communications 2000;270(3):798-805.
2000: M Kodama; H Tsukada; M Ooya; M Onomura; Takatoshi Saito; Kazuhiko Fukuda; Md. Kaimul Ahsan; T Taniguchi; M Tominaga; Masaya Hosokawa; J Fujita; Yutaka Seino
Gastric mucosal damage caused by monochloramine in the rat and protective effect of taurine: endoscopic observation through gastric fistula.
Endoscopy 2000;32(4):294-9.
2000: Minoru Horie; Masato Watanuki; Keiko Tsuji; H Ishida; A Ishida-Takahashi; Y Yuzuki; Yutaka Seino; Shigetake Sasayama
Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit.
Journal of cardiovascular pharmacology 2000;35(3):434-42.
2000: Eri Mukai; H Ishida; Shimpei Fujimoto; Mariko Kajikawa; Yasuo Okamoto; Jun Fujita; Yoshiyuki Hamamoto; Yoshiyuki Tsuura; Yuichiro Yamada; N Furukawa; T Ohta; Yutaka Seino
The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608: direct enhancement of Ca(2+) efficacy and increase of Ca(2+) influx by phosphodiesterase inhibition.
British journal of pharmacology 2000;129(5):901-8.
2000: Yuichiro Yamada; Yutaka Seino
[Genetic factors and insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(2):315-9.
1999: Kazumasa Miyawaki; Yuichiro Yamada; H Yano; Hitoshi Niwa; Nobuhiro Ban; Yu Ihara; A Kubota; Shimpei Fujimoto; M Kajikawa; Akira Kuroe; Kinsuke Tsuda; Hisashi Hashimoto; Takahiro Yamashita; Takahito Jomori; Fumi Tashiro; Jun-ichi Miyazaki; Yutaka Seino
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14843-7.
1999: Kazuhiko Fukuda; M Oya; Yutaka Seino
[Pancreatic polypeptide (PP)].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():353-6.
1999: M M Naruse; I Ohara; T Kobayashi; Yoshimi Itokawa; Yutaka Seino
Effects of taste stimulation on the behavior of serum amino acid concentrations and amylase and trypsin activities in fasting rats.
Journal of nutritional science and vitaminology 1999;45(6):733-46.
1999: Yu Ihara; Yuichiro Yamada; Yutaka Seino
[Multiple risk factor syndrome].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(12):2801-5.
1999: Md. Kaimul Ahsan; H Tsukada; M Oya; M Onomura; Takatoshi Saito; Kazuhiko Fukuda; M Kodama; T Taniguchi; M Tominaga; Masaya Hosokawa; Yutaka Seino
Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells.
Scandinavian journal of gastroenterology 1999;34(11):1117-22.
1999: Mariko Kajikawa; H Ishida; Shimpei Fujimoto; Eri Mukai; M Nishimura; Jun Fujita; Yoshiyuki Tsuura; Yasuo Okamoto; A W Norman; Yutaka Seino
An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction.
Endocrinology 1999;140(10):4706-12.
1999: Yasuhiro Sunaga; Nobuya Inagaki; Tohru Gonoi; Yuichiro Yamada; H Ishida; Yutaka Seino; Susumu Seino
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
European journal of pharmacology 1999;381(1):71-6.
1999: Masaya Hosokawa; H Tsukada; Kazuhiko Fukuda; M Oya; M Onomura; Md. Kaimul Ahsan; M Kodama; Yuichiro Yamada; Yutaka Seino
Troglitazone inhibits bicarbonate secretion in rat and human duodenum.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1080-4.
1999: Yoshiyuki Tsuura; Shimpei Fujimoto; Mariko Kajikawa; H Ishida; Yutaka Seino
Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets.
Biochemical and biophysical research communications 1999;261(2):439-44.
1999: Akari Inada; Yoshimichi Someya; Yuichiro Yamada; Yu Ihara; A Kubota; Nobuhiro Ban; Rie Watanabe; Kinsuke Tsuda; Yutaka Seino
The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID.
The Journal of biological chemistry 1999;274(30):21095-103.
1999: Yoshikatsu Nakai; S Hamagaki; S Kato; Yutaka Seino; R Takagi; F Kurimoto
Role of leptin in women with eating disorders.
The International journal of eating disorders 1999;26(1):29-35.
1999: Jun Fujita; Kinsuke Tsuda; Tomomi Takeda; L Yu; Shimpei Fujimoto; Mariko Kajikawa; M Nishimura; N Mizuno; Yoshiyuki Hamamoto; Eri Mukai; T Adachi; Yutaka Seino
Nisoldipine improves the impaired erythrocyte deformability correlating with elevated intracellular free calcium-ion concentration and poor glycaemic control in NIDDM.
British journal of clinical pharmacology 1999;47(5):499-506.
1999: Nobuyuki Shihara; Koichiro Yasuda; Toshio Moritani; Hidetoshi Ue; Tetsuya Adachi; H Tanaka; Kinsuke Tsuda; Yutaka Seino
The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity.
The Journal of clinical endocrinology and metabolism 1999;84(5):1623-7.
1999: Yu Ihara; Shinya Toyokuni; Kazushige Uchida; H Odaka; Tomoyuki Tanaka; Hiroki Ikeda; Hiroshi Hiai; Yutaka Seino; Yuichiro Yamada
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.
Diabetes 1999;48(4):927-32.
1999: Yuichiro Yamada; Yutaka Seino
[Pathogenesis of impaired insulin secretion in NIDDM].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):534-8.
1999: Yoshikatsu Nakai; S Hamagaki; S Kato; Yutaka Seino; R Takagi; F Kurimoto
Leptin in women with eating disorders.
Metabolism: clinical and experimental 1999;48(2):217-20.
1999: Rie Watanabe; Yuichiro Yamada; Yu Ihara; Yoshimichi Someya; A Kubota; S Kagimoto; Akira Kuroe; T Iwakura; ZP Shen; Akari Inada; Tetsuya Adachi; Nobuhiro Ban; Kazumasa Miyawaki; Yasuhiro Sunaga; Kinsuke Tsuda; Yutaka Seino
The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals.
Biochemical and biophysical research communications 1999;254(3):707-12.
1999: M Onomura; H Tsukada; Kazuhiko Fukuda; Masaya Hosokawa; Md. Kaimul Ahsan; M Kodama; Michihiro Ohya; Yutaka Seino
Effects of ginseng radix on sugar absorption in the small intestine.
The American journal of Chinese medicine 1999;27(3-4):347-54.
1999: Kazuhiko Fukuda; H Tsukada; M Oya; M Onomura; M Kodama; Md. Kaimul Ahsan; Masaya Hosokawa; Yutaka Seino
Adrenomedullin promotes epithelial restitution of rat and human gastric mucosa in vitro.
Peptides 1999;20(1):127-32.
1998: Akari Inada; Yuichiro Yamada; Yoshimichi Someya; A Kubota; Koichiro Yasuda; Yu Ihara; S Kagimoto; Akira Kuroe; Kinsuke Tsuda; Yutaka Seino
Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats.
Biochemical and biophysical research communications 1998;253(3):712-8.
1998: Yoshiyuki Tsuura; H Ishida; T Shinomura; M Nishimura; Yutaka Seino
Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets.
Biochemical and biophysical research communications 1998;252(1):34-8.
1998: H Ishida; Shigeaki Kato; M Nishimura; N Mizuno; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; Yuichiro Yamada; H Odaka; Hiroki Ikeda; Yutaka Seino
Beneficial effect of long-term combined treatment with voglibose and pioglitazone on pancreatic islet function of genetically diabetic GK rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(11):673-8.
1998: Masaya Hosokawa; H Tsukada; T Saitou; M Kodama; M Onomura; Md. Kaimul Ahsan; Kazuhiko Fukuda; Yutaka Seino
Effects of okadaic acid on rat colon.
Digestive diseases and sciences 1998;43(11):2526-35.
1998: Eri Mukai; H Ishida; Minoru Horie; Akinori Noma; Yutaka Seino; Makoto Takano
The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2.
Biochemical and biophysical research communications 1998;251(2):477-81.
1998: T Taniguchi; H Tsukada; Md. Kaimul Ahsan; M Kodama; Kazuhiko Fukuda; T Saito; M Miyasaka; Yutaka Seino
Effects of the anti-ICAM-1 monoclonal antibody on dextran sodium sulphate-induced colitis in rats.
Journal of gastroenterology and hepatology 1998;13(9):945-9.
1998: Yoshiyuki Tsuura; H Ishida; M Nishimura; Shimpei Fujimoto; Mariko Kajikawa; Yutaka Seino
Ouabain suppresses ATP elevation in response to fuel secretagogues in pancreatic islets.
Biochemical and biophysical research communications 1998;249(3):853-7.
1998: K Suzuki; H Ishida; N Takeshita; Y Taguchi; C Sugimoto; K Nosaka; Yutaka Seino
Circulating levels of tartrate-resistant acid phosphatase in rat models of non-insulin-dependent diabetes mellitus.
Journal of diabetes and its complications 1998;12(3):176-80.
1998: N Mizuno; Hideyuki Yoshitomi; H Ishida; H Kuromi; J Kawaki; Yutaka Seino; S Seino
Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion.
Endocrinology 1998;139(3):1429-39.
1998: Shimpei Fujimoto; H Ishida; Shigeaki Kato; Yasuo Okamoto; K Tsuji; N Mizuno; S Ueda; Eri Mukai; Yutaka Seino
The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.
Endocrinology 1998;139(3):1133-40.
1998: M Nishimura; H Ishida; Yoshiyuki Tsuura; Shigeaki Kato; N Mizuno; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; M Usami; Yutaka Seino
Necessity of endogenous GTP derived from glucose-6-phosphate for insulin secretion augmented by glucose under protein kinase A activation.
Biochemical and biophysical research communications 1998;243(1):253-7.
1998: Kazuhiko Fukuda; H Tsukada; M Onomura; Takatoshi Saito; M Kodama; Md. Kaimul Ahsan; T Taniguchi; M Tominaga; Masaya Hosokawa; Yutaka Seino
Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon.
Peptides 1998;19(6):1043-7.
1998: Jun Fujita; Yutaka Seino; Kinsuke Tsuda
[Erythrocyte Na+/Li+ countertransport activity].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():251-7.
1998: Eri Mukai; H Ishida; Shinichi Kato; Yoshiyuki Tsuura; Shimpei Fujimoto; A Ishida-Takahashi; Minoru Horie; K Tsuda; Yutaka Seino
Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic beta-cells.
The American journal of physiology 1998;274(1 Pt 1):E38-44.
1997: M Nishimura; Yutaka Seino
[Secondary forms of diabetes].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():519-27.
1997: A Kubota; Yutaka Seino
[Hexokinase gene].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():478-81.
1997: Kazuhiko Fukuda; H Tsukada; Yutaka Seino
[Gastrointestinal hormones in diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():149-54.
1997: Yoshimichi Someya; H Ishida; Yutaka Seino
[Insulin gene: gene organization and its regulatory mechanism of transcription].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():73-8.
1997: Yutaka Seino; Yoshimichi Someya
[Review: regulatory factors of glucose metabolism].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():67-72.
1997: A Kubota; Yuichiro Yamada; Koichiro Yasuda; Yoshimichi Someya; Yu Ihara; S Kagimoto; Rie Watanabe; Akira Kuroe; H Ishida; Yutaka Seino
Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways.
Biochemical and biophysical research communications 1997;235(1):171-5.
1997: Jun Fujita; Kinsuke Tsuda; H Obayashi; I Fukui; H Ishida; Yutaka Seino
Nisoldipine blocks the increase of intracellular free calcium-ion concentration associated with elevated sodium-lithium countertransport activity in erythrocytes in patients with NIDDM.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(6):499-502.
1997: Minoru Horie; A Ishida-Takahashi; Tomohiko Ai; T Nishimoto; Yoshiyuki Tsuura; H Ishida; Yutaka Seino; Shigetake Sasayama
Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs.
Cardiovascular research 1997;34(1):69-72.
1997: Yuichiro Yamada; Yutaka Seino
[Sulfonylurea receptor].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 2():590-3.
1997: T Taniguchi; H Tsukada; Md. Kaimul Ahsan; M Kodama; Kazuhiko Fukuda; M Tominaga; Yutaka Seino
Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease.
Digestion 1997;58(5):476-8.
1996: A Kubota; Y Yamada; Tadashi Hayami; Koichiro Yasuda; Yoshimichi Someya; Yu Ihara; S Kagimoto; Rie Watanabe; T Taminato; Kinsuke Tsuda; Yutaka Seino
Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects.
Diabetes 1996;45(12):1701-5.
1996: N Okada; A Kubota; T Imamura; H Suwa; Y Kawaguchi; Gakuji Ohshio; Yutaka Seino; Masayuki Imamura
Evaluation of cholecystokinin, gastrin, CCK-A receptor, and CCK-B/gastrin receptor gene expressions in gastric cancer.
Cancer letters 1996;106(2):257-62.
1996: A Kubota; Y Yamada; S Kagimoto; S Seino; Yutaka Seino
Effector coupling of somatostatin receptor subtypes on human endocrine tumors.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):42-5.
1996: S Kato; H Ishida; Yoshiyuki Tsuura; K Tsuji; M Nishimura; Minoru Horie; T Taminato; S Ikehara; H Odaka; I Ikeda; Y Okada; Yutaka Seino
Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats.
The Journal of clinical investigation 1996;97(11):2417-25.
1996: Y Yamada; Yutaka Seino
[Somatostatin and its receptors].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(4):1109-14.
1996: Koichiro Yasuda; Yutaka Seino
[Gastric inhibitory polypeptide (GIP) and GIP receptor (GIPR)].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(4):1078-82.
1996: Kazuaki Miyamoto; Yuichiro Ogura; Hirokazu Nishiwaki; N Matsuda; Yoshihito Honda; S Kato; H Ishida; Yutaka Seino
Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes.
Investigative ophthalmology & visual science 1996;37(5):898-905.
1996: Takuya Inomoto; A Tanaka; Masaaki Awane; M Kanai; H Shinohara; S Hatano; S Sato; T Gomi; K Masuda; Yoshimichi Someya; K Honda; Yutaka Seino; Yoshio Yamaoka
Changes in glucose transporter 2 and carbohydrate-metabolizing enzymes in the liver during cold preservation and warm ischemia.
Transplantation 1996;61(6):869-74.
1996: Jun Fujita; Kinsuke Tsuda; M Seno; H Obayashi; I Fukui; Yutaka Seino
Elevated erythrocyte sodium-lithium countertransport activity correlates with increased intracellular sodium and free calcium-ion concentration in type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(1):53-8.
1995: K Suzuki; H Ishida; C Sugimoto; Y Taguchi; H Matsuda; K Nosaka; Yoshimichi Someya; S Kadowaki; Yutaka Seino
The urinary concentration of sialic acid is increased in non-insulin-dependent diabetic patients with microangiopathy: a possible useful marker for diabetic microangiopathy.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(12):1092-6.
1995: S Kato; H Ishida; Yoshiyuki Tsuura; Yutaka Seino
Altered functions of ion channels in diabetic beta cells.
Obesity research 1995;3 Suppl 5():637S-638S.
1995: Y Yamada; Tadashi Hayami; K Nakamura; P J Kaisaki; Yoshimichi Someya; C Z Wang; S Seino; Yutaka Seino
Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.
Genomics 1995;29(3):773-6.
1995: Yasuo Okamoto; H Ishida; Yoshiyuki Tsuura; K Yasuda; S Kato; H Matsubara; M Nishimura; N Mizuno; H Ikeda; Yutaka Seino
Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.
Diabetologia 1995;38(7):772-8.
1995: Kinsuke Tsuda; Yutaka Seino
[Genetic syndrome with obesity].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Suppl():436-40.
1995: Y Yamada; K Masuda; Q Li; Y Ihara; A Kubota; T Miura; K Nakamura; Y Fujii; S Seino; Yutaka Seino
The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.
Genomics 1995;27(2):312-9.
1995: Yutaka Seino; H Ishida
Diabetic osteopenia: pathophysiology and clinical aspects.
Diabetes/metabolism reviews 1995;11(1):21-35.
1995: Yutaka Seino
[Pancreatic polypeptide (PP)].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 2():648-50.
1995: Yu Ihara; Y Yamada; Y Fujii; T Gonoi; H Yano; K Yasuda; N Inagaki; Yutaka Seino; S Seino
Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(1):121-30.
1995: K Masuda; Yasuo Okamoto; Yoshiyuki Tsuura; S Kato; T Miura; Kinsuke Tsuda; H Horikoshi; H Ishida; Yutaka Seino
Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide.
Diabetologia 1995;38(1):24-30.
1994: Koichiro Yasuda; N Inagaki; Y Yamada; A Kubota; S Seino; Yutaka Seino
Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secreting cells: its structure and functional properties.
Biochemical and biophysical research communications 1994;205(3):1556-62.
1994: Yoshiyuki Tsuura; H Ishida; S Hayashi; K Sakamoto; Minoru Horie; Yutaka Seino
Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells.
The Journal of general physiology 1994;104(6):1079-98.
1994: Yoshiyuki Tsuura; H Ishida; Yasuo Okamoto; S Kato; Minoru Horie; H Ikeda; Yutaka Seino
Reduced sensitivity of dihydroxyacetone on ATP-sensitive K+ channels of pancreatic beta cells in GK rats.
Diabetologia 1994;37(11):1082-7.
1994: S Kato; H Ishida; Yoshiyuki Tsuura; Yasuo Okamoto; K Tsuji; Minoru Horie; Y Okada; Yutaka Seino
Increased calcium-channel currents of pancreatic beta cells in neonatally streptozocin-induced diabetic rats.
Metabolism: clinical and experimental 1994;43(11):1395-400.
1994: A Kubota; Y Yamada; S Kagimoto; Koichiro Yasuda; Yoshimichi Someya; Yu Ihara; Yasuo Okamoto; T Kozasa; S Seino; Yutaka Seino
Multiple effector coupling of somatostatin receptor subtype SSTR1.
Biochemical and biophysical research communications 1994;204(1):176-86.
1994: Koichiro Yasuda; Yutaka Seino
[Candidate gene approach in Japanese NIDDM: liver/pancreatic beta cell type glucose transporter (GLUT2)].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2693-6.
1994: Yutaka Seino; Y Yamada
[Heterogeneity in pathogenesis of NIDDM and recent advances in research of diabetogenic genes].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2686-92.
1994: K Masuda; Q Li; Y Yamada; Yutaka Seino
[The alpha 1 subunit of voltage-dependent calcium channel expressed in pancreatic beta cells].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2593-8.
1994: T Miura; Y Yamada; Yoshimichi Someya; A Kubota; Yutaka Seino
[The detection of GLUT2 gene mutation by polymerase-chain reaction single stranded conformation polymorphism (PCR-SSCP) method].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2568-71.
1994: Yoshimichi Someya; H Fukumoto; Yutaka Seino
[Organization of the human GLUT2 gene and regulation of the GLUT2 gene expression].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2562-7.
1994: Yutaka Seino; Hiroshi Imura
Endocrine disorders and diabetes in Japan.
Diabetes research and clinical practice 1994;24 Suppl():S129-33.
1994: Jun Fujita; Kinsuke Tsuda; M Seno; H Obayashi; I Fukui; Yutaka Seino
Erythrocyte sodium-lithium countertransport activity as a marker of predisposition to hypertension and diabetic nephropathy in NIDDM.
Diabetes care 1994;17(9):977-82.
1994: S Kagimoto; Y Yamada; A Kubota; Yoshimichi Someya; Yu Ihara; Koichiro Yasuda; T Kozasa; Hiroshi Imura; S Seino; Yutaka Seino
Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.
Biochemical and biophysical research communications 1994;202(2):1188-95.
1994: Q Li; Y Yamada; Koichiro Yasuda; Yu Ihara; Yasuo Okamoto; P J Kaisaki; Rie Watanabe; H Ikeda; Kinsuke Tsuda; Yutaka Seino
A cloned rat CD38-homologous protein and its expression in pancreatic islets.
Biochemical and biophysical research communications 1994;202(1):629-36.
1994: A Kubota; Y Yamada; S Kagimoto; Akira Shimatsu; Masayuki Imamura; Kinsuke Tsuda; Hiroshi Imura; S Seino; Yutaka Seino
Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors.
The Journal of clinical investigation 1994;93(3):1321-5.
1994: K Masuda; H Yano; T Miura; M Morimoto; N Kitano; Yutaka Seino
Hind III site causing Proinsulin Kyoto and Pst I site polymorphism of the insulin gene in Japanese: its lack of association with either IDDM or NIDDM.
Endocrine journal 1994;41(1):71-4.
1994: Hitoshi Takagi; Hidenobu Tanihara; Yutaka Seino; Norio Yoshimura
Characterization of glucose transporter in cultured human retinal pigment epithelial cells: gene expression and effect of growth factors.
Investigative ophthalmology & visual science 1994;35(1):170-7.
1993: K Tsuji; T Taminato; H Ishida; Yasuo Okamoto; Yoshiyuki Tsuura; S Kato; Takeshi Kurose; Y Okada; Hiroshi Imura; Yutaka Seino
Selective impairment of the cytoplasmic Ca2+ response to glucose in pancreatic beta cells of streptozocin-induced non-insulin-dependent diabetic rats.
Metabolism: clinical and experimental 1993;42(11):1424-8.
1993: Yoshiyuki Tsuura; H Ishida; Yasuo Okamoto; S Kato; K Sakamoto; Minoru Horie; H Ikeda; Y Okada; Yutaka Seino
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
Diabetes 1993;42(10):1446-53.
1993: S Hayashi; Minoru Horie; Yoshiyuki Tsuura; H Ishida; Y Okada; Yutaka Seino; Shigetake Sasayama
Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release.
The American journal of physiology 1993;265(2 Pt 1):C337-42.
1993: Yoshimichi Someya; N Inagaki; T Maekawa; Yutaka Seino; S Ishii
Two 3',5'-cyclic-adenosine monophosphate response elements in the promoter region of the human gastric inhibitory polypeptide gene.
FEBS letters 1993;317(1-2):67-73.
1993: N Takeshita; H Ishida; T Yamamoto; G Koh; Takeshi Kurose; K Tsuji; Yasuo Okamoto; H Ikeda; Yutaka Seino
Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein in rat models of non-insulin-dependent diabetes mellitus.
Acta endocrinologica 1993;128(1):69-73.
1993: X H Gu; Takeshi Kurose; S Kato; K Masuda; Kinsuke Tsuda; H Ishida; Yutaka Seino
Suppressive effect of GABA on insulin secretion from the pancreatic beta-cells in the rat.
Life sciences 1993;52(8):687-94.
1993: Yutaka Seino; T Yamamoto; K Inoue; Masayuki Imamura; S Kadowaki; H Kojima; J Fujikawa; Hiroshi Imura
Abnormal facilitative glucose transporter gene expression in human islet cell tumors.
The Journal of clinical endocrinology and metabolism 1993;76(1):75-8.
1992: Yasuo Okamoto; H Ishida; T Taminato; K Tsuji; Takeshi Kurose; Yoshiyuki Tsuura; S Kato; Hiroshi Imura; Yutaka Seino
Role of cytosolic Ca2+ in impaired sensitivity to glucose of rat pancreatic islets exposed to high glucose in vitro.
Diabetes 1992;41(12):1555-61.
1992: Y Yamada; T Reisine; S F Law; Yu Ihara; A Kubota; S Kagimoto; M Seino; Yutaka Seino; Graeme I Bell; S Seino
Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2136-42.
1992: Takeshi Kurose; Kinsuke Tsuda; H Ishida; K Tsuji; Yasuo Okamoto; Yoshiyuki Tsuura; S Kato; M Usami; Hiroshi Imura; Yutaka Seino
Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro.
Diabetologia 1992;35(11):1035-41.
1992: Yoshiyuki Tsuura; H Ishida; Yasuo Okamoto; K Tsuji; Takeshi Kurose; Minoru Horie; Hiroshi Imura; Y Okada; Yutaka Seino
Impaired glucose sensitivity of ATP-sensitive K+ channels in pancreatic beta-cells in streptozotocin-induced NIDDM rats.
Diabetes 1992;41(7):861-5.
1992: H Ishida; Yutaka Seino; N Takeshita; Takeshi Kurose; K Tsuji; Yasuo Okamoto; Yoshimichi Someya; K Hara; Y Akiyama; Hiroshi Imura
Effect of pancreas transplantation on decreased levels of circulating bone gamma-carboxyglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes.
Acta endocrinologica 1992;127(1):81-5.
1992: H Yano; N Kitano; M Morimoto; Kenneth S Polonsky; Hiroshi Imura; Yutaka Seino
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
The Journal of clinical investigation 1992;89(6):1902-7.
1992: Yutaka Seino; T Yamamoto; G Koh
Insulin and glucose transporter gene expression in obesity and diabetes.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(2):210-3.
1992: N Inagaki; T Maekawa; T Sudo; S Ishii; Yutaka Seino; H Imura
c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1045-9.
1992: Koichiro Yasuda; Y Yamada; N Inagaki; H Yano; Yasuo Okamoto; K Tsuji; H Fukumoto; Hiroshi Imura; Susumu Seino; Yutaka Seino
Expression of GLUT1 and GLUT2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose.
Diabetes 1992;41(1):76-81.
1991: Yutaka Seino; H Ishida
The pathophysiology and etiology of diabetic osteopenia.
Japanese journal of medicine 1991;30(6):624-6.
1991: Yutaka Seino; H Ishida
[Diabetes mellitus and its complications in Japan. The pathophysiology and etiology of diabetic osteopenia].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1991;80(9):1446-50.
1991: T Yamamoto; H Fukumoto; G Koh; H Yano; Koichiro Yasuda; K Masuda; H Ikeda; Hiroshi Imura; Yutaka Seino
Liver and muscle-fat type glucose transporter gene expression in obese and diabetic rats.
Biochemical and biophysical research communications 1991;175(3):995-1002.
1991: Hiroshi Imura; Hideshi Kuzuya; Yutaka Seino
[MHC class II antigen and other genes in NIDDM].
Nihon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():531-6.
1991: H Yano; Yutaka Seino; N Inagaki; Y Hinokio; T Yamamoto; Koichiro Yasuda; K Masuda; Yoshimichi Someya; Hiroshi Imura
Tissue distribution and species difference of the brain type glucose transporter (GLUT3).
Biochemical and biophysical research communications 1991;174(2):470-7.
1990: Hiroshi Imura; Yutaka Seino; H Fukumoto
[Glucose transporters].
Nihon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():39-47.
1990: Kinsuke Tsuda; Yutaka Seino
[Secondary diabetes].
Nihon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():203-8.
1990: Yutaka Seino; H Yano; N Inagaki
[Gastrointestinal hormones in diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():113-9.
1990: G Koh; Yutaka Seino; M Usami; T Matsuo; H Ikeda; T Yamamoto; Kinsuke Tsuda; T Taminato; Hiroshi Imura
Importance of imparied insulin-gene expression in occurrence of diabetes in obese rats.
Diabetes 1990;39(9):1050-6.
1990: T Yamamoto; Yutaka Seino; H Fukumoto; G Koh; H Yano; N Inagaki; Y Yamada; K Inoue; T Manabe; Hiroshi Imura
Over-expression of facilitative glucose transporter genes in human cancer.
Biochemical and biophysical research communications 1990;170(1):223-30.
1990: Y Yamada; Yutaka Seino; J Takeda; H Fukumoto; H Yano; N Inagaki; Y Fukuda; S Seino; Hiroshi Imura
Increase in liver glucose transporter mRNA levels during rat liver regeneration.
Biochemical and biophysical research communications 1990;168(3):1274-9.
1990: H Yano; Yutaka Seino
[Motilin--structure and tissue specific expression of the human motilin gene and motilin receptor].
Nihon rinsho. Japanese journal of clinical medicine 1990;48(5):1005-10.
1990: Yutaka Seino
[Plasma pancreatic polypeptide assay and the clinical significance].
Nihon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():40-2.
1990: Takeshi Kurose; Yutaka Seino; S Nishi; K Tsuji; T Taminato; Kinsuke Tsuda; Hiroshi Imura
Mechanism of sympathetic neural regulation of insulin, somatostatin, and glucagon secretion.
The American journal of physiology 1990;258(1 Pt 1):E220-7.
1989: H Yano; Yutaka Seino; J Fujita; Y Yamada; N Inagaki; J Takeda; Graeme I Bell; R L Eddy; Yao-Shan Fan; M G Byers
Exon-intron organization, expression, and chromosomal localization of the human motilin gene.
FEBS letters 1989;249(2):248-52.
1989: N Inagaki; Yutaka Seino; J Takeda; H Yano; Y Yamada; Graeme I Bell; R L Eddy; Y Fukushima; M G Byers; T B Shows
Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.
Molecular endocrinology (Baltimore, Md.) 1989;3(6):1014-21.
1989: J Takeda; S Ishii; Yutaka Seino; F Imamoto; Hiroshi Imura
Negative regulation of human insulin gene expression by the 5'-flanking region in non-pancreatic cells.
FEBS letters 1989;247(1):41-5.
1989: G Koh; Yutaka Seino; J Takeda; H Fukumoto; Takeshi Kurose; K Tsuji; Kinsuke Tsuda; T Taminato; Hiroshi Imura
Short term effects of glucose and arginine on the preproinsulin messenger ribonucleic acid level in the perfused rat pancreas: comparison with insulin secretion.
Endocrinology 1989;124(2):707-11.
1989: N Takeshita; Y Seino; H Ishida; Yutaka Seino; H Tanaka; C Tsutsumi; K Ogata; K Kiyohara; H Kato; M Nozawa
Increased circulating levels of gamma-carboxyglutamic acid-containing protein and decreased bone mass in children on anticonvulsant therapy.
Calcified tissue international 1989;44(2):80-5.
1988: A Kosaki; Hideshi Kuzuya; Yasunao Yoshimasa; Kenneth M Yamada; M Okamoto; Haruo Nishimura; T Kakehi; J Takeda; Yutaka Seino; Hiroshi Imura
Regulation of glucose-transporter gene expression by insulin in cultured human fibroblasts.
Diabetes 1988;37(11):1583-6.
1988: H Ishida; Y Seino; T Taminato; M Usami; N Takeshita; Yutaka Seino; C Tsutsumi; S Moriuchi; Y Akiyama; K Hara
Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein are decreased in streptozocin-induced diabetes. Possible marker for diabetic osteopenia.
Diabetes 1988;37(6):702-6.
1988: M Seno; Yutaka Seino; T Taminato; Kinsuke Tsuda; N Kitano; J Takeda; H Fukumoto; G Koh; Hiroshi Imura
Comparative effect of somatostatin-14 and somatostatin-28 on glucagon-induced glycogenolysis from the perfused rat liver.
Metabolism: clinical and experimental 1988;37(6):587-90.
1988: N Kitano; T Taminato; T Ida; M Seno; Yutaka Seino; S Matsukura; S Kuno; Hiroshi Imura
Detection of antibodies against wheat germ agglutinin bound glycoproteins on the islet-cell membrane.
Diabetic medicine : a journal of the British Diabetic Association 1988;5(2):139-44.
1988: M Usami; Yutaka Seino; T Taminato; M Seno; G Koh; M Ohno; M Ikeda; Hiroshi Imura
Effect of DG5128 on epinephrine and glucagon induced glucose output from the isolated perfused rat liver.
Life sciences 1988;42(2):129-36.
1988: M Seno; Kinsuke Tsuda; N Kitano; J Takeda; H Fukumoto; G Koh; Hiroshi Imura; T Taminato; Yutaka Seino
Degradation and conversion of somatostatin in normal and diabetic rats in vivo and in vitro.
Canadian journal of physiology and pharmacology 1988;66(1):55-60.
1988: Takeshi Kurose; Yutaka Seino; H Ishida; K Tsuji; H Fukumoto; G Koh; J Takeda; N Kitano; N Inagaki; Kinsuke Tsuda
Effect of vitamin D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach.
Life sciences 1988;42(20):1995-2001.
1987: Yutaka Seino; K Tanaka; J Takeda; H Takahashi; T Mitani; M Kurono; T Kayano; G Koh; H Fukumoto; H Yano
Sequence of an intestinal cDNA encoding human motilin precursor.
FEBS letters 1987;223(1):74-6.
1987: S Nishi; Yutaka Seino; N Kitano; M Seno; K Tsuji; Takeshi Kurose; T Taminato; Kinsuke Tsuda; C Yanaihara; N Yanaihara
Effects of naloxone on basal and vagus nerve-induced secretions of GRP, gastrin, and somatostatin from the isolated perfused rat stomach.
Life sciences 1987;41(15):1787-93.
1987: J Takeda; Yutaka Seino; K Tanaka; H Fukumoto; T Kayano; H Takahashi; T Mitani; M Kurono; T Suzuki; T Tobe
Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7005-8.
1986: H Fukumoto; Yutaka Seino; G Koh; J Takeda; K Tsuji; Takeshi Kurose; N Kitano; Kinsuke Tsuda; T Taminato; Hiroshi Imura
Effects of oral glucose administration on preproinsulin mRNA in rats in vivo.
Biochemical and biophysical research communications 1986;141(3):1201-6.
1985: M Shima; Yutaka Seino; Y Tanaka; H Yabuuchi; C Tsutsumi; S Moriuchi
Bone gamma-carboxyglutamic acid containing protein in the perinatal period.
Acta paediatrica Scandinavica 1985;74(5):674-7.
1985: H Ishida; Yutaka Seino; S Nishi; N Kitano; M Seno; T Taminato; S Matsukura; S Ishizuka; Hiroshi Imura
Effects of insulin on altered mineral and vitamin D metabolism in streptozotocin-induced diabetes.
Acta endocrinologica 1985;108(2):231-6.
1985: M Seno; Yutaka Seino; Y Takemura; S Nishi; H Ishida; N Kitano; Hiroshi Imura; T Taminato; S Matsukura
Comparison of somatostatin-28 and somatostatin-14 clearance by the perfused rat liver.
Canadian journal of physiology and pharmacology 1985;63(1):62-7.
1984: Takeshi Kurose; Yutaka Seino; H Ishida; J Fujita; T Taminato; M Matsukura; Hiroshi Imura
Successful treatment of metastatic glucagonoma with dacarbazine.
Lancet 1984;1(8377):621-2.