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Mineaki Seki

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Matthew Hogg; Mineaki Seki; Richard D Wood; Sylvie Doublié; Susan S Wallace
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
Shinsuke Ito; Li Jing Tan; Daisuke Andoh; Takashi Narita; Mineaki Seki; Yasuhiro Hirano; Keiko Narita; Isao Kuraoka; Yasushi Hiraoka; Kiyoji Tanaka
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

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All Publications

2011: Matthew Hogg; Mineaki Seki; Richard D Wood; Sylvie Doublié; Susan S Wallace
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
Journal of molecular biology 2011;405(3):642-52.
2010: Shinsuke Ito; Li Jing Tan; Daisuke Andoh; Takashi Narita; Mineaki Seki; Yasuhiro Hirano; Keiko Narita; Isao Kuraoka; Yasushi Hiraoka; Kiyoji Tanaka
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Molecular cell 2010;39(4):632-40.
2010: Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13390-5.
2010: Kei-ichi Takata; Mercedes E Arana; Mineaki Seki; Thomas A Kunkel; Richard D Wood
Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity.
Nucleic acids research 2010;38(10):3233-44.
2009: Julie P Goff; Donna S Shields; Mineaki Seki; Serah Choi; Michael W Epperly; Tracy Dixon; Hong Wang; Christopher J Bakkenist; Stephen D Dertinger; Dorothea K Torous; John Wittschieben; Richard D Wood; Joel S Greenberger
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
Radiation research 2009;172(2):165-74.
2008: Mercedes E Arana; Mineaki Seki; Richard D Wood; Igor Rogozin; Thomas A Kunkel
Low-fidelity DNA synthesis by human DNA polymerase theta.
Nucleic acids research 2008;36(11):3847-56.
2008: Mineaki Seki; Richard D Wood
DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct.
DNA repair 2008;7(1):119-27.
2007: Keiji Masuda; Rika Ouchida; Masaki Hikida; Tomohiro Kurosaki; Masayuki Yokoi; Chikahide Masutani; Mineaki Seki; Richard D Wood; Fumio Hanaoka; Jiyang O-Wang
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.
The Journal of biological chemistry 2007;282(24):17387-94.
2006: Michio Yoshimura; Masaoki Kohzaki; Jun Nakamura; Kenjiro Asagoshi; Eiichiro Sonoda; Esther W Hou; Rajendra Prasad; Samuel H Wilson; Keizo Tano; Akira Yasui; Li Lan; Mineaki Seki; Richard D Wood; Hiroshi Arakawa; Jean-Marie Buerstedde; Helfrid Hochegger; Takashi Okada; Masahiro Hiraoka; Shunichi Takeda
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.
Molecular cell 2006;24(1):115-25.
2005: Mineaki Seki; Patricia J Gearhart; Richard D Wood
DNA polymerases and somatic hypermutation of immunoglobulin genes.
EMBO reports 2005;6(12):1143-8.
2004: Mineaki Seki; Chikahide Masutani; Lee-Wei Yang; Anthony Schuffert; Shigenori Iwai; Ivet Bahar; Richard D Wood
High-efficiency bypass of DNA damage by human DNA polymerase Q.
The EMBO journal 2004;23(22):4484-94.
2003: Mineaki Seki; Federica Marini; Richard D Wood
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.
Nucleic acids research 2003;31(21):6117-26.