FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Mutsuo Sekiguchi

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Physiology

Genes & Molecular Sequences

Procedures

Cloning, Molecular

Co-author Network

Publications

TOP 3
Takeshi Sekiguchi; Hiroshi Hayakawa; Riyoko Ito; Mutsuo Sekiguchi
Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors.
Teik How Lim; Yoshimichi Nakatsu; Ryuji Sakagami; Shiori Sano; Mutsuo Sekiguchi; Teruhisa Tsuzuki; Ryosuke Fujikane; Masumi Hidaka
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
Hiroshi Hayakawa; Mutsuo Sekiguchi
Human polynucleotide phosphorylase protein in response to oxidative stress.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Mutsuo Sekiguchi (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Takeshi Sekiguchi; Hiroshi Hayakawa; Riyoko Ito; Mutsuo Sekiguchi
Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors.
The Journal of biological chemistry 2013;288(12):8128-35.
2012: Teik How Lim; Yoshimichi Nakatsu; Ryuji Sakagami; Shiori Sano; Mutsuo Sekiguchi; Teruhisa Tsuzuki; Ryosuke Fujikane; Masumi Hidaka
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
DNA repair 2012;11(3):259-66.
2006: Hiroshi Hayakawa; Mutsuo Sekiguchi
Human polynucleotide phosphorylase protein in response to oxidative stress.
Biochemistry 2006;45(21):6749-55.
2003: Kunihiko Sakumi; Yohei Tominaga; Masato Furuichi; Ping Xu; Teruhisa Tsuzuki; Mutsuo Sekiguchi; Yusaku Nakabeppu
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Cancer research 2003;63(5):902-5.
2002: Akinori Egashira; Kazumi Yamauchi; Kaoru Yoshiyama; Hisaya Kawate; Motoya Katsuki; Mutsuo Sekiguchi; Keizo Sugimachi; Hisaji Maki; Teruhisa Tsuzuki
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.
DNA repair 2002;1(11):881-93.
2002: Hiroshi Hayakawa; Takeshi Uchiumi; Takao Fukuda; Megumi Ashizuka; Kimitoshi Kohno; Michihiko Kuwano; Mutsuo Sekiguchi
Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine.
Biochemistry 2002;41(42):12739-44.
2002: Masayuki Takahashi; Fabrice Maraboeuf; Yasunari Sakai; Hiroyuki Yakushiji; Masaki Mishima; Masahiro Shirakawa; Shigenori Iwai; Hiroshi Hayakawa; Mutsuo Sekiguchi; Yusaku Nakabeppu
Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein.
Journal of molecular biology 2002;319(1):129-39.
2001: Teruhisa Tsuzuki; Akinori Egashira; H Igarashi; Tomoo Iwakuma; Y Nakatsuru; Yohei Tominaga; Hisaya Kawate; Kazuwa Nakao; Kozo Nakamura; F Ide; Shinobu Kura; Yusaku Nakabeppu; Motoya Katsuki; T Ishikawa; Mutsuo Sekiguchi
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11456-61.
2001: Hiroshi Hayakawa; Michihiko Kuwano; Mutsuo Sekiguchi
Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein.
Biochemistry 2001;40(33):9977-82.
2000: A Shiraishi; Kunihiko Sakumi; Mutsuo Sekiguchi
Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.
Carcinogenesis 2000;21(10):1879-83.
2000: Kenichi Miyako; Chihiro Takamatsu; Shuyo Umeda; T Tajiri; Masato Furuichi; Yusaku Nakabeppu; Mutsuo Sekiguchi; Naotaka Hamasaki; Koichiro Takeshige; Dongchon Kang
Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA.
The Journal of biological chemistry 2000;275(16):12326-30.
2000: Hisaya Kawate; R Itoh; Kunihiko Sakumi; Yusaku Nakabeppu; Teruhisa Tsuzuki; F Ide; T Ishikawa; T Noda; Hajime Nawata; Mutsuo Sekiguchi
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Carcinogenesis 2000;21(2):301-5.
1999: Y Fujii; H Shimokawa; Mutsuo Sekiguchi; Yusaku Nakabeppu
Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins.
The Journal of biological chemistry 1999;274(53):38251-9.
1999: Hisanobu Oda; A Taketomi; R Maruyama; R Itoh; Kenichi Nishioka; Hiroyuki Yakushiji; T Suzuki; Mutsuo Sekiguchi; Yusaku Nakabeppu
Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.
Nucleic acids research 1999;27(22):4335-43.
1999: Hiroshi Hayakawa; A Hofer; L Thelander; S Kitajima; Y Cai; S Oshiro; Hiroyuki Yakushiji; Yusaku Nakabeppu; Michihiko Kuwano; Mutsuo Sekiguchi
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells.
Biochemistry 1999;38(12):3610-4.
1998: Toshio Ohtsubo; Osamu Matsuda; Koh Iba; isamu terashima; Mutsuo Sekiguchi; Yusaku Nakabeppu
Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product.
Molecular & general genetics : MGG 1998;259(6):577-90.
1998: Hisaya Kawate; Kunihiko Sakumi; Teruhisa Tsuzuki; Y Nakatsuru; T Ishikawa; S Takahashi; H Takano; T Noda; Mutsuo Sekiguchi
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5116-20.
1997: Hiroyuki Yakushiji; Fabrice Maraboeuf; Masayuki Takahashi; Z S Deng; S Kawabata; Yusaku Nakabeppu; Mutsuo Sekiguchi
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Mutation research 1997;384(3):181-94.
1997: Tomoo Iwakuma; Kunihiko Sakumi; Y Nakatsuru; Hisaya Kawate; H Igarashi; A Shiraishi; Teruhisa Tsuzuki; T Ishikawa; Mutsuo Sekiguchi
High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.
Carcinogenesis 1997;18(8):1631-5.
1997: Hisanobu Oda; Yusaku Nakabeppu; Masato Furuichi; Mutsuo Sekiguchi
Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products.
The Journal of biological chemistry 1997;272(28):17843-50.
1997: Kunihiko Sakumi; A Shiraishi; Shuji Shimizu; Teruhisa Tsuzuki; T Ishikawa; Mutsuo Sekiguchi
Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.
Cancer research 1997;57(12):2415-8.
1997: Y Tominaga; Teruhisa Tsuzuki; A Shiraishi; Hisaya Kawate; Mutsuo Sekiguchi
Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.
Carcinogenesis 1997;18(5):889-96.
1997: J P Cai; Hisaya Kawate; Kenji Ihara; Hiroyuki Yakushiji; Yusaku Nakabeppu; Teruhisa Tsuzuki; Mutsuo Sekiguchi
Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity.
Nucleic acids research 1997;25(6):1170-6.
1997: H Igarashi; T Tsuzuki; T Kakuma; Yohei Tominaga; Mutsuo Sekiguchi
Organization and expression of the mouse MTH1 gene for preventing transversion mutation.
The Journal of biological chemistry 1997;272(6):3766-72.
1996: Tomoo Iwakuma; A Shiraishi; M Fukuhara; Hisaya Kawate; Mutsuo Sekiguchi
Organization and expression of the mouse gene for DNA repair methyltransferase.
DNA and cell biology 1996;15(10):863-72.
1996: Teruhisa Tsuzuki; Y Fujii; Kunihiko Sakumi; Y Tominaga; Kazuwa Nakao; Mutsuo Sekiguchi; A Matsushiro; Y Yoshimura
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6236-40.
1996: A Taketomi; Yusaku Nakabeppu; K Ihara; D J Hart; Masato Furuichi; Mutsuo Sekiguchi
Requirement for two conserved cysteine residues in the Ada protein of Escherichia coli for transactivation of the ada promoter.
Molecular & general genetics : MGG 1996;250(5):523-32.
1996: Mutsuo Sekiguchi
MutT-related error avoidance mechanism for DNA synthesis.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(2):139-45.
1996: Mutsuo Sekiguchi; Yusaku Nakabeppu; Kunihiko Sakumi; T Tuzuki
DNA-repair methyltransferase as a molecular device for preventing mutation and cancer.
Journal of cancer research and clinical oncology 1996;122(4):199-206.
1995: T Kakuma; J Nishida; Teruhisa Tsuzuki; Mutsuo Sekiguchi
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution.
The Journal of biological chemistry 1995;270(43):25942-8.
1995: J P Cai; T Kakuma; Teruhisa Tsuzuki; Mutsuo Sekiguchi
cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.
Carcinogenesis 1995;16(10):2343-50.
1995: Hisaya Kawate; K Ihara; Kohfuku Kohda; Kunihiko Sakumi; Mutsuo Sekiguchi
Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.
Carcinogenesis 1995;16(7):1595-602.
1995: Dongchon Kang; J Nishida; A Iyama; Yusaku Nakabeppu; Masato Furuichi; T Fujiwara; Mutsuo Sekiguchi; Koichiro Takeshige
Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.
The Journal of biological chemistry 1995;270(24):14659-65.
1995: T Tajiri; H Maki; Mutsuo Sekiguchi
Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli.
Mutation research 1995;336(3):257-67.
1995: H Hayakawa; A Taketomi; Kunihiko Sakumi; M Kuwano; Mutsuo Sekiguchi
Generation and elimination of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, a mutagenic substrate for DNA synthesis, in human cells.
Biochemistry 1995;34(1):89-95.
1994: Masato Furuichi; M C Yoshida; Hisanobu Oda; T Tajiri; Yusaku Nakabeppu; Teruhisa Tsuzuki; Mutsuo Sekiguchi
Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.
Genomics 1994;24(3):485-90.
1994: T Ishibashi; Yusaku Nakabeppu; Hisaya Kawate; Kunihiko Sakumi; H Hayakawa; Mutsuo Sekiguchi
Intracellular localization and function of DNA repair methyltransferase in human cells.
Mutation research 1994;315(3):199-212.
1994: K Ihara; Hisaya Kawate; L L Chueh; H Hayakawa; Mutsuo Sekiguchi
Requirement of the Pro-Cys-His-Arg sequence for O6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening.
Molecular & general genetics : MGG 1994;243(4):379-89.
1994: T Ito; T Nakamura; H Maki; Mutsuo Sekiguchi
Roles of transcription and repair in alkylation mutagenesis.
Mutation research 1994;314(3):273-85.
1994: A Iyama; Kunihiko Sakumi; Yusaku Nakabeppu; Mutsuo Sekiguchi
A unique structural feature of rabbit DNA repair methyltransferase as revealed by cDNA cloning.
Carcinogenesis 1994;15(4):627-33.
1994: T Ishibashi; Yusaku Nakabeppu; Mutsuo Sekiguchi
Artificial control of nuclear translocation of DNA repair methyltransferase.
The Journal of biological chemistry 1994;269(10):7645-50.
1993: Kunihiko Sakumi; Masato Furuichi; Teruhisa Tsuzuki; T Kakuma; Shun-ichiro Kawabata; H Maki; Mutsuo Sekiguchi
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
The Journal of biological chemistry 1993;268(31):23524-30.
1993: Kunihiko Sakumi; K Igarashi; Mutsuo Sekiguchi; A Ishihama
The Ada protein is a class I transcription factor of Escherichia coli.
Journal of bacteriology 1993;175(8):2455-7.
1993: Y Nakatsu; K Hattori; H Hayakawa; K Shimizu; Mutsuo Sekiguchi
Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase.
Mutation research 1993;293(2):119-32.
1992: Masato Furuichi; C G Yu; M Anai; Kunihiko Sakumi; Mutsuo Sekiguchi
Regulatory elements for expression of the alkA gene in response to alkylating agents.
Molecular & general genetics : MGG 1992;236(1):25-32.
1992: J Y Mo; H Maki; Mutsuo Sekiguchi
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11021-5.
1992: K Takahashi; M Suzuki; Mutsuo Sekiguchi; Y Kawazoe
Effect of metal ions on transcription of the ada gene which encodes O6-methylguanine-DNA methyltransferase of Escherichia coli.
Chemical & pharmaceutical bulletin 1992;40(9):2483-6.
1992: L L Chueh; T Nakamura; Y Nakatsu; Kunihiko Sakumi; H Hayakawa; Mutsuo Sekiguchi
Specific amino acid sequences required for O6-methylguanine-DNA methyltransferase activity: analyses of three residues at or near the methyl acceptor site.
Carcinogenesis 1992;13(5):837-43.
1992: A Shiraishi; Kunihiko Sakumi; Y Nakatsu; H Hayakawa; Mutsuo Sekiguchi
Isolation and characterization of cDNA and genomic sequences for mouse O6-methylguanine-DNA methyltransferase.
Carcinogenesis 1992;13(2):289-96.
1992: H Maki; Mutsuo Sekiguchi
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.
Nature 1992;355(6357):273-5.
1992: M Fukuhara; H Hayakawa; Kunihiko Sakumi; Mutsuo Sekiguchi
Induced synthesis of O6-methylguanine-DNA methyltransferase in rat hepatoma cells exposed to DNA-damaging agents.
Japanese journal of cancer research : Gann 1992;83(1):72-7.
1992: Mutsuo Sekiguchi; J Y Mo; H Maki
Molecular mechanisms for controlling spontaneous and induced mutagenesis.
Nucleic acids symposium series 1992;(27):101-2.
1991: J Y Mo; H Maki; Mutsuo Sekiguchi
Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli.
Journal of molecular biology 1991;222(4):925-36.
1991: Kunihiko Sakumi; A Shiraishi; H Hayakawa; Mutsuo Sekiguchi
Cloning and expresion of cDNA for rat O6-methylguanine-DNA methyltransferase.
Nucleic acids research 1991;19(20):5597-601.
1991: M Suzuki; K Takahashi; Y Kawazoe; Kunihiko Sakumi; Mutsuo Sekiguchi
Inhibitory effect of cadmium and mercury ions on transcription of the ada gene.
Biochemical and biophysical research communications 1991;179(3):1517-21.
1991: Yoshimitsu Mizunoe; T Matsumoto; Kazunobu Amako; Mutsuo Sekiguchi; J Kumazawa
Identification and nucleotide sequence of the gene determining the adhesion capacity of Serratia marcescens.
Journal of bacteriology 1991;173(10):3257-60.
1991: H Maki; J Y Mo; Mutsuo Sekiguchi
A strong mutator effect caused by an amino acid change in the alpha subunit of DNA polymerase III of Escherichia coli.
The Journal of biological chemistry 1991;266(8):5055-61.
1991: K Takano; T Nakamura; Mutsuo Sekiguchi
Roles of two types of O6-methylguanine-DNA methyltransferases in DNA repair.
Mutation research 1991;254(1):37-44.
1990: H Akimaru; Kunihiko Sakumi; T Yoshikai; M Anai; Mutsuo Sekiguchi
Positive and negative regulation of transcription by a cleavage product of Ada protein.
Journal of molecular biology 1990;216(2):261-73.
1990: G Koike; H Maki; H Takeya; H Hayakawa; Mutsuo Sekiguchi
Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.
The Journal of biological chemistry 1990;265(25):14754-62.
1990: Kunihiko Sakumi; Mutsuo Sekiguchi
Structures and functions of DNA glycosylases.
Mutation research 1990;236(2-3):161-72.
1990: H Hayakawa; G Koike; Mutsuo Sekiguchi
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.
Journal of molecular biology 1990;213(4):739-47.
1990: K Takahashi; Mutsuo Sekiguchi; Y Kawazoe
Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli.
Mutation research 1990;230(2):127-34.
1990: H Maki; M Akiyama; T Horiuchi; Mutsuo Sekiguchi
Molecular mechanisms of replicational fidelity in Escherichia coli.
Basic life sciences 1990;52():299-308.
1989: K I Kodama; Yusaku Nakabeppu; Mutsuo Sekiguchi
Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells.
Mutation research 1989;218(2):153-63.
1989: K Takahashi; Mutsuo Sekiguchi; Y Kawazoe
A specific inhibition of induction of adaptive response by o-vanillin, a potent comutagen.
Biochemical and biophysical research communications 1989;162(3):1376-81.
1989: M Akiyama; H Maki; Mutsuo Sekiguchi; T Horiuchi
A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3949-52.
1989: Mutsuo Sekiguchi; H Hayakawa; K Kodama; K Ishizaki; M Ikenaga
[Role of O6-methylguanine-DNA methyltransferase in repair of DNA damaged by alkylating agents].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):466-72.
1989: Kunihiko Sakumi; Mutsuo Sekiguchi
Regulation of expression of the ada gene controlling the adaptive response. Interactions with the ada promoter of the Ada protein and RNA polymerase.
Journal of molecular biology 1989;205(2):373-85.
1988: T Yoshikai; Yusaku Nakabeppu; Mutsuo Sekiguchi
Proteolytic cleavage of Ada protein that carries methyltransferase and transcriptional regulator activities.
The Journal of biological chemistry 1988;263(35):19174-80.
1988: K Takahashi; Kohfuku Kohda; T Oh-hara; Mutsuo Sekiguchi; Y Kawazoe
Structural requirement for the induction of the adaptive response in Escherichia coli among N-(substituted alkyl)-N-nitrosoureas.
Mutation research 1988;202(1):193-201.
1988: K Takahashi; Y Kawazoe; Kunihiko Sakumi; Yusaku Nakabeppu; Mutsuo Sekiguchi
Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents.
The Journal of biological chemistry 1988;263(27):13490-2.
1988: T Nakamura; Y Tokumoto; Kunihiko Sakumi; G Koike; Yusaku Nakabeppu; Mutsuo Sekiguchi
Expression of the ada gene of Escherichia coli in response to alkylating agents. Identification of transcriptional regulatory elements.
Journal of molecular biology 1988;202(3):483-94.
1988: Yoshimitsu Mizunoe; Y Nakabeppu; Mutsuo Sekiguchi; Shun-ichiro Kawabata; T Moriya; Kazunobu Amako
Cloning and sequence of the gene encoding the major structural component of mannose-resistant fimbriae of Serratia marcescens.
Journal of bacteriology 1988;170(8):3567-74.
1988: K Takano; Yusaku Nakabeppu; Mutsuo Sekiguchi
Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions.
Journal of molecular biology 1988;201(2):261-71.
1987: T Horiuchi; M Hidaka; M Akiyama; H Nishitani; Mutsuo Sekiguchi
Replication intermediate of a hybrid plasmid carrying the replication terminus (ter) site of R 6K as revealed by agarose gel electrophoresis.
Molecular & general genetics : MGG 1987;210(3):394-8.
1987: M Ohtsubo; R Kai; Nobuaki Furuno; Takeshi Sekiguchi; Mutsuo Sekiguchi; H Hayashida; K Kuma; T Miyata; S Fukushige; T Murotsu
Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.
Genes & development 1987;1(6):585-93.
1986: K Shimizu; Y Nakatsu; S Nomoto; Mutsuo Sekiguchi
Structure of the activated c-raf-1 gene from human stomach cancer.
Princess Takamatsu symposia 1986;17():85-91.