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Yuichi Sekine

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Yuichi Sekine; Y Ueno; Akihiko Yoshimura; Osamu Ikeda; Y Kanakura; A Mizushima; Ryuta Muromoto; Kenji Oritani; Tadashi Matsuda
STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
Yuichi Sekine; Chikako Yamamoto; Akihiko Yoshimura; Ryuta Muromoto; Kenji Oritani; Dai Ashitomi; Natsuko Fujita; Michinori Kakisaka; Shigeyuki Kon; Tadashi Matsuda
Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
Shinya Kamitani; Osamu Ikeda; Ryuta Muromoto; Misa Nakasuji; Kenji Oritani; Asuka Sakauchi; Yuichi Sekine; Sumihito Togi; Tadashi Matsuda
Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65.

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All Publications

2012: Yuichi Sekine; Y Ueno; Akihiko Yoshimura; Osamu Ikeda; Y Kanakura; A Mizushima; Ryuta Muromoto; Kenji Oritani; Tadashi Matsuda
STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
Oncogene 2012;31(40):4384-96.
2012: Yuichi Sekine; Chikako Yamamoto; Akihiko Yoshimura; Ryuta Muromoto; Kenji Oritani; Dai Ashitomi; Natsuko Fujita; Michinori Kakisaka; Shigeyuki Kon; Tadashi Matsuda
Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6194-204.
2011: Shinya Kamitani; Osamu Ikeda; Ryuta Muromoto; Misa Nakasuji; Kenji Oritani; Asuka Sakauchi; Yuichi Sekine; Sumihito Togi; Tadashi Matsuda
Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2476-83.
2011: Masayuki Ishizaki; Hiroaki Maeda; Toshihiko Akimoto; Ryuta Muromoto; Yuya Ohshiro; Kenji Oritani; Yuichi Sekine; Kazuya Shimoda; Miki Takahashi; Tadashi Matsuda
Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
International immunology 2011;23(9):575-82.
2011: Masayuki Ishizaki; Hiroaki Maeda; Toshihiko Akimoto; Ryuta Muromoto; Yuya Ohshiro; Kenji Oritani; Yuichi Sekine; Kazuya Shimoda; Mika Yokoyama; Tadashi Matsuda
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):181-9.
2011: Osamu Ikeda; Akihiro Mizushima; Yuichi Sekine; Chikako Yamamoto; Ryuta Muromoto; Asuka Nanbo; Kenji Oritani; Akihiko Yoshimura; Tadashi Matsuda
Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Cancer science 2011;102(4):756-61.
2010: Ryuta Muromoto; Makoto Kuroda; Sumihito Togi; Yuichi Sekine; Asuka Nanbo; Kazuya Shimoda; Kenji Oritani; Tadashi Matsuda
Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells.
European journal of immunology 2010;40(12):3570-80.
2010: Yuichi Sekine
[Novel adaptor protein, STAP-2 functions as a signal modulator in immune system].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(6):769-75.
2010: Osamu Ikeda; Yuto Miyasaka; Ryuji Yoshida; Akihiro Mizushima; Kenji Oritani; Yuichi Sekine; Makoto Kuroda; Teruhito Yasui; Masahiro Fujimuro; Ryuta Muromoto; Asuka Nanbo; Tadashi Matsuda
BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
FEBS letters 2010;584(5):865-72.
2009: Yuichi Sekine; Osamu Ikeda; Satoshi Tsuji; Chikako Yamamoto; Ryuta Muromoto; Asuka Nanbo; Kenji Oritani; Akihiko Yoshimura; Tadashi Matsuda
Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7966-74.
2009: Osamu Ikeda; Sumihito Togi; Shinya Kamitani; Ryuta Muromoto; Yuichi Sekine; Asuka Nanbo; Masahiro Fujimuro; Tadashi Matsuda
Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.
Biological & pharmaceutical bulletin 2009;32(7):1283-5.
2009: Yuichi Sekine; Chikako Yamamoto; Osamu Ikeda; Ryuta Muromoto; Asuka Nanbo; Kenji Oritani; Akihiko Yoshimura; Tadashi Matsuda
The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
Biochemical and biophysical research communications 2009;384(2):187-92.
2009: Osamu Ikeda; Yuto Miyasaka; Yuichi Sekine; Akihiro Mizushima; Ryuta Muromoto; Asuka Nanbo; Akihiko Yoshimura; Tadashi Matsuda
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.
Biochemical and biophysical research communications 2009;384(1):71-5.
2009: Osamu Ikeda; Yuichi Sekine; Akihiro Mizushima; Kenji Oritani; Teruhito Yasui; Masahiro Fujimuro; Ryuta Muromoto; Asuka Nanbo; Tadashi Matsuda
BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1.
FEBS letters 2009;583(10):1567-74.
2009: Ryuta Muromoto; Naohisa Taira; Osamu Ikeda; Kaname Shiga; Shinya Kamitani; Sumihito Togi; Shiho Kawakami; Yuichi Sekine; Asuka Nanbo; Kenji Oritani; Tadashi Matsuda
The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.
Biochemical and biophysical research communications 2009;382(1):63-8.
2008: Osamu Ikeda; Yuichi Sekine; Ryuta Muromoto; Norihiko Ohbayashi; Akihiko Yoshimura; Tadashi Matsuda
Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice.
Biological & pharmaceutical bulletin 2008;31(9):1790-3.
2008: Norihiko Ohbayashi; Katsuya Okada; Shiho Kawakami; Sumihito Togi; Noriko Sato; Osamu Ikeda; Shinya Kamitani; Ryuta Muromoto; Yuichi Sekine; Taro Kawai; Shizuo Akira; Tadashi Matsuda
Physical and functional interactions between ZIP kinase and UbcH5.
Biochemical and biophysical research communications 2008;372(4):708-12.
2008: Osamu Ikeda; Yuichi Sekine; Teruhito Yasui; Kenji Oritani; Kenji Sugiyma; Ryuta Muromoto; Norihiko Ohbayashi; Akihiko Yoshimura; Tadashi Matsuda
STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.
Molecular and cellular biology 2008;28(16):5027-42.
2008: Norihiko Ohbayashi; Naohisa Taira; Shiho Kawakami; Sumihito Togi; Noriko Sato; Osamu Ikeda; Shinya Kamitani; Ryuta Muromoto; Yuichi Sekine; Tadashi Matsuda
An RNA biding protein, Y14 interacts with and modulates STAT3 activation.
Biochemical and biophysical research communications 2008;372(3):475-9.
2008: Norihiko Ohbayashi; Shiho Kawakami; Ryuta Muromoto; Sumihito Togi; Osamu Ikeda; Shinya Kamitani; Yuichi Sekine; Tsutomu Honjoh; Tadashi Matsuda
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.
Biochemical and biophysical research communications 2008;371(4):823-8.
2008: Seiyu Imoto; Norihiko Ohbayashi; Osamu Ikeda; Shinya Kamitani; Ryuta Muromoto; Yuichi Sekine; Tadashi Matsuda
Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.
Biochemical and biophysical research communications 2008;370(2):359-65.
2008: Shinya Kamitani; Norihiko Ohbayashi; Osamu Ikeda; Sumihito Togi; Ryuta Muromoto; Yuichi Sekine; Kazuhide Ohta; Hironobu Ishiyama; Tadashi Matsuda
KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression.
Biochemical and biophysical research communications 2008;370(2):366-70.
2008: R Tsuruma; Norihiko Ohbayashi; S Kamitani; Osamu Ikeda; Noriko Sato; Ryuta Muromoto; Yuichi Sekine; Kenji Oritani; Tadashi Matsuda
Physical and functional interactions between STAT3 and KAP1.
Oncogene 2008;27(21):3054-9.
2008: Ryuta Muromoto; Yuichi Sekine; Seiyu Imoto; Osamu Ikeda; Taichiro Okayama; Noriko Sato; Tadashi Matsuda
BART is essential for nuclear retention of STAT3.
International immunology 2008;20(3):395-403.
2007: Norihiko Ohbayashi; Osamu Ikeda; Naohisa Taira; Yu Yamamoto; Ryuta Muromoto; Yuichi Sekine; Kenji Sugiyama; Tsutomu Honjoh; Tadashi Matsuda
LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.
Biological & pharmaceutical bulletin 2007;30(10):1860-4.
2007: Yuichi Sekine; Osamu Ikeda; Y Hayakawa; Satoshi Tsuji; S Imoto; Naohito Aoki; Kenji Sugiyama; Tadashi Matsuda
DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.
Oncogene 2007;26(41):6038-49.
2007: Yuichi Sekine; Satoshi Tsuji; Osamu Ikeda; Kenji Sugiyma; Kenji Oritani; Kazuya Shimoda; Ryuta Muromoto; Norihiko Ohbayashi; Akihiko Yoshimura; Tadashi Matsuda
Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2397-407.
2007: Osamu Ikeda; Yuichi Sekine; Michinori Kakisaka; Satoshi Tsuji; Ryuta Muromoto; Norihiko Ohbayashi; Kenji Oritani; Akihiko Yoshimura; Tadashi Matsuda
STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells.
Biochemical and biophysical research communications 2007;358(3):931-7.
2007: Yuichi Sekine; Satoshi Tsuji; Osamu Ikeda; Michinori Kakisaka; Kenji Sugiyama; Akihiko Yoshimura; Tadashi Matsuda
Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity.
Biochemical and biophysical research communications 2007;356(2):517-22.
2006: Yuichi Sekine; Satoshi Tsuji; Osamu Ikeda; Noriko Sato; Naohito Aoki; K Aoyama; Kenji Sugiyama; Tadashi Matsuda
Regulation of STAT3-mediated signaling by LMW-DSP2.
Oncogene 2006;25(42):5801-6.
2006: Ryuta Muromoto; Masato Ishida; Kenji Sugiyama; Yuichi Sekine; Kenji Oritani; Kazuya Shimoda; Tadashi Matsuda
Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1160-70.
2006: Ryuta Muromoto; K Nakao; T Watanabe; Noriko Sato; Yuichi Sekine; Kenji Sugiyama; Kenji Oritani; Kazuya Shimoda; Tadashi Matsuda
Physical and functional interactions between Daxx and STAT3.
Oncogene 2006;25(14):2131-6.
2006: Noriko Sato; Nobuyuki Kamada; Ryuta Muromoto; Taro Kawai; Kenji Sugiyama; Tadashi Watanabe; Seiyu Imoto; Yuichi Sekine; Norihiko Ohbayashi; Masato Ishida; Shizuo Akira; Tadashi Matsuda
Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.
Immunology letters 2006;103(2):127-34.
2006: Yuichi Sekine; Taro Yumioka; Tetsuya Yamamoto; Ryuta Muromoto; Seiyu Imoto; Kenji Sugiyma; Kenji Oritani; Kazuya Shimoda; Mayu Minoguchi; Shizuo Akira; Akihiko Yoshimura; Tadashi Matsuda
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):380-9.
2005: Noriko Sato; Taro Kawai; Kenji Sugiyama; Ryuta Muromoto; Seiyu Imoto; Yuichi Sekine; Masato Ishida; Shizuo Akira; Tadashi Matsuda
Physical and functional interactions between STAT3 and ZIP kinase.
International immunology 2005;17(12):1543-52.
2005: Noriko Sato; Rieko Tsuruma; Seiyu Imoto; Yuichi Sekine; Ryuta Muromoto; Kenji Sugiyama; Tadashi Matsuda
Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
Biochemical and biophysical research communications 2005;336(2):617-24.
2005: Toshihiro Yokoyama; Seiichi Okamura; Yoshinobu Asano; Kenjirou Kamezaki; Akihiko Numata; Haruko Kakumitsu; Kotaro Shide; Hitoshi Nakashima; Kanaji Taisuke; Yuichi Sekine; Yumi Mizuno; Jun Okamura; Tadashi Matsuda; Mine Harada; Niho Yoshiyuki; Kazuya Shimoda
A novel mutation in the juxtamembrane intracellular sequence of the granulocyte colony-stimulating factor (G-CSF) receptor gene in a patient with severe congenital neutropenia augments GCSF proliferation activity but not through the MAP kinase cascade.
International journal of hematology 2005;82(1):28-34.
2005: Seiyu Imoto; Kenji Sugiyama; Yuichi Sekine; Tadashi Matsuda
Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.
FEBS letters 2005;579(13):2853-62.
2005: Yuichi Sekine; Tetsuya Yamamoto; Taro Yumioka; Kenji Sugiyama; Satoshi Tsuji; Kenji Oritani; Kazuya Shimoda; Mayu Minoguchi; Akihiko Yoshimura; Tadashi Matsuda
Physical and functional interactions between STAP-2/BKS and STAT5.
The Journal of biological chemistry 2005;280(9):8188-96.
2004: Tadashi Matsuda; Jian Feng; bruce witthuhn; Yuichi Sekine; James N Ihle
Determination of the transphosphorylation sites of Jak2 kinase.
Biochemical and biophysical research communications 2004;325(2):586-94.
2004: Takashi Haro; Kazuya Shimoda; Haruko Kakumitsu; Kenjirou Kamezaki; Akihiko Numata; Fumihiko Ishikawa; Yuichi Sekine; Ryuta Muromoto; Tadashi Matsuda; Mine Harada
Tyrosine kinase 2 interacts with and phosphorylates receptor for activated C kinase-1, a WD motif-containing protein.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1151-7.
2004: Yuichi Sekine; Tetsuya Yamamoto; Taro Yumioka; Seiyu Imoto; Hiroyuki Kojima; Tadashi Matsuda
Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
Biochemical and biophysical research communications 2004;315(3):692-8.
2004: Tetsuya Yamamoto; Seiyu Imoto; Yuichi Sekine; Kenji Sugiyama; Toshihiko Akimoto; Atsushi Muraguchi; Tadashi Matsuda
Involvement of NF-kappaB in TGF-beta-mediated suppression of IL-4 signaling.
Biochemical and biophysical research communications 2004;313(3):627-34.
2003: Tetsuya Yamamoto; Taro Yumioka; Yuichi Sekine; Noriko Sato; Mayu Minoguchi; Akihiko Yoshimura; Tadashi Matsuda
Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.
Biochemical and biophysical research communications 2003;306(3):767-73.
2003: Tetsuya Yamamoto; Noriko Sato; Yuichi Sekine; Taro Yumioka; Seiyu Imoto; Akira Junicho; Hideki Fuse; Tadashi Matsuda
Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor.
Biochemical and biophysical research communications 2003;306(2):610-5.
2003: Ryuta Muromoto; Tetsuya Yamamoto; Taro Yumioka; Yuichi Sekine; Kenji Sugiyama; Kazuya Shimoda; Kenji Oritani; Tadashi Matsuda
Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.
FEBS letters 2003;540(1-3):223-8.
2003: Noriko Sato; Tetsuya Yamamoto; Yuichi Sekine; Taro Yumioka; Akira Junicho; Hideki Fuse; Tadashi Matsuda
Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
Biochemical and biophysical research communications 2003;300(4):847-52.
2002: Tetsuya Yamamoto; Yuichi Sekine; Keiichi Kashima; Atsuko Kubota; Noriko Sato; Naohito Aoki; Tadashi Matsuda
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
Biochemical and biophysical research communications 2002;297(4):811-7.