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Dennis Selkoe

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Thomas Koeglsperger; Shaomin Li; Lior Mayo; Jessica L Saulnier; Dennis J Selkoe; Christian Brenneis; Yijun Carrier; Howard L Weiner
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Shaomin Li; Hongjun Fu; Ming Jin; Thomas Koeglsperger; Ting Yang; Dainan Zhang; Dennis J Selkoe
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.
Ting Yang; Soyon Hong; Tiernan O'Malley; Reisa A Sperling; Dominic M Walsh; Dennis J Selkoe
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

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2013: Thomas Koeglsperger; Shaomin Li; Lior Mayo; Jessica L Saulnier; Dennis J Selkoe; Christian Brenneis; Yijun Carrier; Howard L Weiner
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Glia 2013;61(6):985-1002.
2013: Shaomin Li; Hongjun Fu; Ming Jin; Thomas Koeglsperger; Ting Yang; Dainan Zhang; Dennis J Selkoe
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.
Neuron 2013;77(5):929-41.
2013: Ting Yang; Soyon Hong; Tiernan O'Malley; Reisa A Sperling; Dominic M Walsh; Dennis J Selkoe
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2013;9(2):99-112.
2012: David M Holtzman; Eckhard Mandelkow; Dennis J Selkoe
Alzheimer disease in 2020.
Cold Spring Harbor perspectives in medicine 2012;2(11):.
2012: Heather C Rice; Dennis J Selkoe; Seiyam Suth; Matthew Townsend; Jilin Bai; William Cavanaugh; Tracy L Young-Pearse
Pancortins interact with amyloid precursor protein and modulate cortical cell migration.
Development (Cambridge, England) 2012;139(21):3986-96.
2012: Dennis J Selkoe
Preventing Alzheimer's disease.
Science (New York, N.Y.) 2012;337(6101):1488-92.
2012: Lennart Mucke; Dennis J Selkoe
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.
Cold Spring Harbor perspectives in medicine 2012;2(7):a006338.
2012: Alain Koyama; Olivia I Okereke; Dennis J Selkoe; Ting Yang; Deborah Blacker; Francine Grodstein
Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis.
Archives of neurology 2012;69(7):824-31.
2012: Colin L Masters; Dennis J Selkoe
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.
Cold Spring Harbor perspectives in medicine 2012;2(6):a006262.
2012: Oliver Holmes; Swetha Paturi; Michael S Wolfe; Wenjuan Ye; Dennis J Selkoe
Effects of membrane lipids on the activity and processivity of purified γ-secretase.
Biochemistry 2012;51(17):3565-75.
2012: Eugenia Yakunin; Shlomo Yehuda; Yoel Yaari; Yoav Biala; Haya Kisos; Virginie Loeb; Dennis J Selkoe; Ronit Sharon
Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.
Brain pathology (Zurich, Switzerland) 2012;22(3):280-94.
2012: Victor L Villemagne; Michael W Weiner; David J Brooks; Bradley T Hyman; Milos D Ikonomovic; Kenji Ishii; Clifford R Jack; William J Jagust; Keith A Johnson; William E Klunk; Robert A Koeppe; Val J Lowe; Colin L Masters; Chester A Mathis; Thomas J Montine; John C Morris; Agneta Nordberg; Ronald C Petersen; Eric M Reiman; Christopher C Rowe; Dennis J Selkoe; Reisa A Sperling; Koen Van Laere; Alexander Drzezga
Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease.
European journal of nuclear medicine and molecular imaging 2012;39(2):209-19.
2012: Mary K Townsend; Weiming Xia; Ting Yang; Olivia I Okereke; Dennis J Selkoe; Francine Grodstein
Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study.
Alzheimer disease and associated disorders 2012;26(1):50-4.
2011: John C Morris; Dennis J Selkoe
Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview.
Neurobiology of aging 2011;32 Suppl 1():S1-3.
2011: Darragh B Freir; Rocio Fedriani; Darren Scully; Dennis J Selkoe; Imelda M Smith; Dominic M Walsh; Ciaran M Regan
Aβ oligomers inhibit synapse remodelling necessary for memory consolidation.
Neurobiology of aging 2011;32(12):2211-8.
2011: Soyon Hong; Beth L Ostaszewski; Daniel R Podlisny; Omar Quintero-Monzon; William T Cavanaugh; John R Cirrito; David M Holtzman; Ting Yang; Dennis J Selkoe
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(44):15861-9.
2011: Nina E Shepardson; Ganesh M Shankar; Dennis J Selkoe
Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.
Archives of neurology 2011;68(11):1385-92.
2011: Nina E Shepardson; Ganesh M Shankar; Dennis J Selkoe
Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies.
Archives of neurology 2011;68(10):1239-44.
2011: Hongliu Ding; Alice W Flaherty; John H Growdon; Michael T Hayes; Albert Y Hung; Bradley T Hyman; Adrian J Ivinson; Caroline G Kan; Nancy E Maher; Bernard M Ravina; Sarah S Roderick; Andrea Santarlasci; Alison K Sarokhan; Michael G Schlossmacher; Michael A Schwarzschild; Dennis J Selkoe; U Shivraj Sohur; Lewis R Sudarsky; Kyleen E Swords; Vivek K Unni; Anne-Marie Wills; Paymon Ashourian; Rachit Bakshi; Sunny Chang; Clemens R Scherzer
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
Movement disorders : official journal of the Movement Disorder Society 2011;26(12):2283-6.
2011: Dennis J Selkoe
Resolving controversies on the path to Alzheimer's therapeutics.
Nature medicine 2011;17(9):1060-5.
2011: Tim Bartels; Joanna G Choi; Dennis J Selkoe
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.
Nature 2011;477(7362):107-10.
2011: Dennis J Selkoe
Alzheimer's disease.
Cold Spring Harbor perspectives in biology 2011;3(7):.
2011: Cathrin Meissner; Holger Lorenz; Andreas Weihofen; Dennis J Selkoe; Marius K Lemberg
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Journal of neurochemistry 2011;117(5):856-67.
2011: Shaomin Li; Ming Jin; Thomas Koeglsperger; Nina E Shepardson; Ganesh M Shankar; Dennis J Selkoe
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(18):6627-38.
2011: Olivia I Okereke; Dennis J Selkoe; Francine Grodstein
Plasma beta-amyloid level, cognitive reserve, and cognitive decline.
JAMA : the journal of the American Medical Association 2011;305(16):1655; author reply 1655-6.
2011: Ming Jin; Nina Shepardson; Ting Yang; Gang Chen; Dominic Walsh; Dennis J Selkoe
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5819-24.
2011: Richard C Davis; I Marsden; Michael T Maloney; Laurie S Minamide; Marcia Podlisny; Dennis J Selkoe; James R Bamburg
Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation.
Molecular neurodegeneration 2011;6():10.
2011: Ganesh M Shankar; Alfred T Welzel; Jessica M McDonald; Dennis J Selkoe; Dominic M Walsh
Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain.
Methods in molecular biology (Clifton, N.J.) 2011;670():33-44.
2010: Tracy L Young-Pearse; Seiyam Suth; Eric S Luth; Akira Sawa; Dennis J Selkoe
Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(31):10431-40.
2010: Michael S Wolfe; Dennis J Selkoe
Giving Alzheimer's the old one-two.
Cell 2010;142(2):194-6.
2010: Jessica M Mc Donald; George Savva; Carol Brayne; Alfred T Welzel; Gill Forster; Ganesh M Shankar; Dennis J Selkoe; Paul Geoffrey Ince; Dominic M Walsh
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.
Brain : a journal of neurology 2010;133(Pt 5):1328-41.
2010: Allen C Chen; Lucie Y Guo; Beth L Ostaszewski; Dennis J Selkoe; Matthew J LaVoie
Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
The Journal of biological chemistry 2010;285(15):11378-91.
2010: Carlo Sala Frigerio; Julia V Fadeeva; Aedín M Minogue; Martin Citron; Fred Van Leuven; Matthias Staufenbiel; Paolo Paganetti; Dennis J Selkoe; Dominic M Walsh
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
The FEBS journal 2010;277(6):1503-18.
2010: Reisa Sperling; Bradford C Dickerson; Maija Pihlajamaki; Patrizia Vannini; Peter S LaViolette; Ottavio V Vitolo; Trey Hedden; J Alex Becker; Dorene M Rentz; Dennis J Selkoe; Keith A Johnson
Functional alterations in memory networks in early Alzheimer's disease.
Neuromolecular medicine 2010;12(1):27-43.
2010: Malcolm Leissring; Enrico Malito; Sabrine Hedouin; Lael Reinstatler; Tomoko Sahara; Samer Abdul-Hay; Shakeel Choudhry; Ghulam M Maharvi; Abdul Fauq; Malwina Huzarska; Philip S May; Sungwoon Choi; Todd P Logan; Benjamin E Turk; Lewis C Cantley; Marika Manolopoulou; Wei-Jen Tang; Ross L Stein; Gregory D Cuny; Dennis J Selkoe
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
PloS one 2010;5(5):e10504.
2010: Shaomin Li; Ganesh M Shankar; Dennis J Selkoe
How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity?
Frontiers in cellular neuroscience 2010;4():5.
2010: Ira Espuny-Camacho; Diana Dominguez; Pascal Merchiers; Luc Van Rompaey; Dennis J Selkoe; Bart De Strooper
Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance.
Journal of Alzheimer's disease : JAD 2010;20(4):1119-32.
2009: Ganesh M Shankar; Malcolm Leissring; Anthony Adame; Xiaoyan Sun; Edward Spooner; Eliezer Masliah; Dennis J Selkoe; Cynthia A Lemere; Dominic M Walsh
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Neurobiology of disease 2009;36(2):293-302.
2009: Olivia I Okereke; Weiming Xia; Dennis J Selkoe; Francine Grodstein
Ten-year change in plasma amyloid beta levels and late-life cognitive decline.
Archives of neurology 2009;66(10):1247-53.
2009: Irit Rappley; David S Myers; Stephen B Milne; Pavlina T Ivanova; Matthew J LaVoie; H Alex Brown; Dennis J Selkoe
Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.
Journal of neurochemistry 2009;111(1):15-25.
2009: Victor Zota; Anna Nemirovsky; Rona Baron; Yair Fisher; Dennis J Selkoe; Daniel M Altmann; Howard L Weiner; Alon Monsonego
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3522-30.
2009: Reisa Sperling; Peter S Laviolette; Kelly O'Keefe; Jacqueline O'Brien; Dorene M Rentz; Maija Pihlajamaki; Gad Marshall; Bradley T Hyman; Dennis J Selkoe; Trey Hedden; Randy L Buckner; J Alex Becker; Keith A Johnson
Amyloid deposition is associated with impaired default network function in older persons without dementia.
Neuron 2009;63(2):178-88.
2009: Shaomin Li; Soyon Hong; Nina E Shepardson; Dominic M Walsh; Ganesh M Shankar; Dennis J Selkoe
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.
Neuron 2009;62(6):788-801.
2009: Aedín M Minogue; Adam K Stubbs; Carlo Sala Frigerio; Barry Boland; Julia V Fadeeva; Jordan Tang; Dennis J Selkoe; Dominic M Walsh
gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.
Brain research 2009;1262():89-99.
2009: Huilin Li; Michael S Wolfe; Dennis J Selkoe
Toward structural elucidation of the gamma-secretase complex.
Structure (London, England : 1993) 2009;17(3):326-34.
2009: Andreas Weihofen; Kelly Jean Thomas; Beth L Ostaszewski; Mark Cookson; Dennis J Selkoe
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry 2009;48(9):2045-52.
2009: Irit Rappley; Aaron D Gitler; Paige E Selvy; Matthew J LaVoie; Bruce D Levy; H Alex Brown; Susan Lindquist; Dennis J Selkoe
Evidence that alpha-synuclein does not inhibit phospholipase D.
Biochemistry 2009;48(5):1077-83.
2009: Weiming Xia; Ting Yang; Ganesh Shankar; Imelda M Smith; Yong Shen; Dominic M Walsh; Dennis J Selkoe
A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Archives of neurology 2009;66(2):190-9.
2009: Tziona Ben Gedalya; Virginie Loeb; Eitan Israeli; Yoram Altschuler; Dennis J Selkoe; Ronit Sharon
Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling.
Traffic (Copenhagen, Denmark) 2009;10(2):218-34.
2009: Olivia I Okereke; Dennis J Selkoe; Michael N Pollak; Meir J Stampfer; Frank B Hu; Susan E Hankinson; Francine Grodstein
A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation.
International journal of geriatric psychiatry 2009;24(2):177-82.
2009: Pamela Osenkowski; Huilin Li; Wenjuan Ye; Dongyang Li; Lorene Aeschbach; Patrick C Fraering; Michael S Wolfe; Dennis J Selkoe; Huilin Li
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.
Journal of molecular biology 2009;385(2):642-52.
2009: Matthew L Hemming; Josh Elias; Steven P Gygi; Dennis J Selkoe
Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
PloS one 2009;4(12):e8477.
2009: Christelle Cabrol; Malwina A Huzarska; Christopher Dinolfo; Maria C Rodriguez; Lael Reinstatler; Jake Ni; Li-An Yeh; Gregory D Cuny; Ross L Stein; Dennis J Selkoe; Malcolm Leissring
Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.
PloS one 2009;4(4):e5274.
2009: Olivia I Okereke; Weiming Xia; Michael C Irizarry; Xiaoyan Sun; Wei Q Qiu; Anne M Fagan; Pankaj D Mehta; Bradley T Hyman; Dennis J Selkoe; Francine Grodstein
Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Journal of Alzheimer's disease : JAD 2009;16(2):277-85.
2008: Matthew L Hemming; Josh Elias; Steven P Gygi; Dennis J Selkoe
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.
PLoS biology 2008;6(10):e257.
2008: Vicki Betts; Malcolm Leissring; Georgia Dolios; Rong Wang; Dennis J Selkoe; Dominic M Walsh
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.
Neurobiology of disease 2008;31(3):442-50.
2008: Dennis J Selkoe
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.
Behavioural brain research 2008;192(1):106-13.
2008: Pamela Osenkowski; Wenjuan Ye; Rong Wang; Michael S Wolfe; Dennis J Selkoe
Direct and potent regulation of gamma-secretase by its lipid microenvironment.
The Journal of biological chemistry 2008;283(33):22529-40.
2008: Ganesh M Shankar; Shaomin Li; Tapan H Mehta; Amaya Garcia-Munoz; Nina E Shepardson; Imelda Smith; Francesca M Brett; Michael A Farrell; Michael J Rowan; Cynthia A Lemere; Ciaran M Regan; Dominic M Walsh; Bernardo L Sabatini; Dennis J Selkoe
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Nature medicine 2008;14(8):837-42.
2008: Marie Neant-Fery; Rubén D Garcia-Ordoñez; Todd P Logan; Dennis J Selkoe; Lilin Li; Lael Reinstatler; Malcolm Leissring
Molecular basis for the thiol sensitivity of insulin-degrading enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9582-7.
2008: Olivia I Okereke; Michael N Pollak; Frank B Hu; Susan E Hankinson; Dennis J Selkoe; Francine Grodstein
Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes.
Psychoneuroendocrinology 2008;33(4):455-61.
2008: Igor Klyubin; Vicki Betts; Alfred T Welzel; Kaj Blennow; Henrik Zetterberg; Anders Wallin; Cynthia A Lemere; William K Cullen; Ying Peng; Thomas Wisniewski; Dennis J Selkoe; Roger Anwyl; Dominic M Walsh; Michael J Rowan
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4231-7.
2008: Babak Nazer; Soyon Hong; Dennis J Selkoe
LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model.
Neurobiology of disease 2008;30(1):94-102.
2008: Andreas Weihofen; Beth L Ostaszewski; Yasufumi Minami; Dennis J Selkoe
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Human molecular genetics 2008;17(4):602-16.
2008: Dennis J Selkoe
Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease.
Handbook of clinical neurology 2008;89():245-60.
2008: Tracy L Young-Pearse; Allen C Chen; Rui Chang; Cesar Marquez; Dennis J Selkoe
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.
Neural development 2008;3():15.
2008: Matthias Cacquevel; Lorene Aeschbach; Pamela Osenkowski; Dongyang Li; Wenjuan Ye; Michael S Wolfe; Huilin Li; Dennis J Selkoe; Patrick C Fraering
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.
Journal of neurochemistry 2008;104(1):210-20.
2007: Tracy L Young-Pearse; Jilin Bai; Rui Chang; Jessica B Zheng; joe loturco; Dennis J Selkoe
A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(52):14459-69.
2007: Dennis J Selkoe
Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease.
Nutrition reviews 2007;65(12 Pt 2):S239-43.
2007: Karen Assayag; Evgenia Yakunin; Virginie Loeb; Dennis J Selkoe; Ronit Sharon
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.
The American journal of pathology 2007;171(6):2000-11.
2007: Matthew Townsend; Tapan Mehta; Dennis J Selkoe
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
The Journal of biological chemistry 2007;282(46):33305-12.
2007: Dennis J Selkoe; Michael S Wolfe
Presenilin: running with scissors in the membrane.
Cell 2007;131(2):215-21.
2007: Matthew L Hemming; Michaela Patterson; Casper Reske-Nielsen; Ling Lin; Ole Isacson; Dennis J Selkoe
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.
PLoS medicine 2007;4(8):e262.
2007: Wesley Farris; Sonja G Schütz; John R Cirrito; Ganesh M Shankar; Xiaoyan Sun; Ana George; Malcolm Leissring; Dominic M Walsh; Wei Qiao Qiu; David M Holtzman; Dennis J Selkoe
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
The American journal of pathology 2007;171(1):241-51.
2007: Dominic M Walsh; Dennis J Selkoe
A beta oligomers - a decade of discovery.
Journal of neurochemistry 2007;101(5):1172-84.
2007: Wei Qiao Qiu; Xiaoyan Sun; Dennis J Selkoe; D Mkaya Mwamburi; Tina Huang; Refeeque Bhadela; Peter Bergethon; Tammy M Scott; Paul Summergrad; Lixia Wang; Irwin Rosenberg; MARSHAL FOLSTEIN
Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.
International journal of geriatric psychiatry 2007;22(6):536-42.
2007: Dominic M Walsh; Aedín M Minogue; C Sala Frigerio; Julia V Fadeeva; Wilma Wasco; Dennis J Selkoe
The APP family of proteins: similarities and differences.
Biochemical Society transactions 2007;35(Pt 2):416-20.
2007: Matthew L Hemming; Dennis J Selkoe; Wesley Farris
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease.
Neurobiology of disease 2007;26(1):273-81.
2007: Minji Kim; Louis B Hersh; Malcolm Leissring; Martin Ingelsson; Toshifumi Matsui; Wesley Farris; Alice Lu; Bradley T Hyman; Dennis J Selkoe; Lars Bertram; Rudolph E Tanzi
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Ganesh M Shankar; Brenda L Bloodgood; Matthew Townsend; Dominic M Walsh; Dennis J Selkoe; Bernardo L Sabatini
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(11):2866-75.
2007: Allen C Chen; Dennis J Selkoe
Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554.
Neuron 2007;53(4):479-83.
2007: Christian Haass; Dennis J Selkoe
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Nature reviews. Molecular cell biology 2007;8(2):101-12.
2006: Matthew Townsend; James P Cleary; Tapan Mehta; Jacki Hofmeister; Sylvain Lesne; Eugene O'Hare; Dominic M Walsh; Dennis J Selkoe
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
Annals of neurology 2006;60(6):668-76.
2006: Malcolm Leissring; Dennis J Selkoe
Structural biology: enzyme target to latch on to.
Nature 2006;443(7113):761-2.
2006: Kim A Celone; Vince D Calhoun; Bradford C Dickerson; Alireza Atri; Elizabeth F Chua; Saul L Miller; Kristina DePeau; Dorene M Rentz; Dennis J Selkoe; Deborah Blacker; Marilyn S Albert; Reisa Sperling
Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10222-31.
2006: Dennis J Selkoe
The ups and downs of Abeta.
Nature medicine 2006;12(7):758-9; discussion 759.
2006: Vlado K Lazarov; Patrick C Fraering; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe; Huilin Li
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6889-94.
2006: Matthew Townsend; Ganesh M Shankar; Tapan Mehta; Dominic M Walsh; Dennis J Selkoe
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
The Journal of physiology 2006;572(Pt 2):477-92.
2006: Marloes Réchards; Weiming Xia; Viola Oorschot; Suzanne M van Dijk; Willem ANNAERT; Dennis J Selkoe; Judith Klumperman
Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Traffic (Copenhagen, Denmark) 2006;7(3):354-64.
2006: Dennis J Selkoe
Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):163-8.
2005: Patrick C Fraering; Wenjuan Ye; Matthew J LaVoie; Beth L Ostaszewski; Dennis J Selkoe; Michael S Wolfe
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
The Journal of biological chemistry 2005;280(51):41987-96.
2005: Matthew L Hemming; Dennis J Selkoe
Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.
The Journal of biological chemistry 2005;280(45):37644-50.
2005: Dominic M Walsh; Igor Klyubin; Ganesh M Shankar; Matthew Townsend; Julia V Fadeeva; V Betts; Marcia B Podlisny; James P Cleary; Karen K. Hsiao Ashe; Michael J Rowan; Dennis J Selkoe
The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.
Biochemical Society transactions 2005;33(Pt 5):1087-90.
2005: Brian M Whalen; Dennis J Selkoe; Dean Hartley
Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration.
Neurobiology of disease 2005;20(2):254-66.
2005: Matthew J LaVoie; Beth L Ostaszewski; Andreas Weihofen; Michael G Schlossmacher; Dennis J Selkoe
Dopamine covalently modifies and functionally inactivates parkin.
Nature medicine 2005;11(11):1214-21.
2005: Dennis J Selkoe
By the way, doctor. Is there a brain scan that can specifically diagnose Alzheimer's disease?
Harvard health letter / from Harvard Medical School 2005;30(12):8.
2005: W Taylor Kimberly; Jessica B Zheng; Terrence Town; Richard A Flavell; Dennis J Selkoe
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5533-43.
2005: Wesley Farris; Malcolm Leissring; Matthew L Hemming; Alice Y Chang; Dennis J Selkoe
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
Biochemistry 2005;44(17):6513-25.
2005: Igor Klyubin; Dominic M Walsh; Cynthia A Lemere; William K Cullen; Ganesh M Shankar; Vicki Betts; Edward T Spooner; Liying Jiang; Roger Anwyl; Dennis J Selkoe; Michael J Rowan
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
Nature medicine 2005;11(5):556-61.
2005: Dominic M Walsh; Matthew Townsend; Marcia B Podlisny; Ganesh M Shankar; Julia V Fadeeva; Omar M A El-Agnaf; Dean Hartley; Dennis J Selkoe
Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2455-62.
2005: Jay H Chyung; Daniel M Raper; Dennis J Selkoe
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
The Journal of biological chemistry 2005;280(6):4383-92.
2005: Dennis J Selkoe
Defining molecular targets to prevent Alzheimer disease.
Archives of neurology 2005;62(2):192-5.
2005: James P Cleary; Dominic M Walsh; Jacki J Hofmeister; Ganesh M Shankar; Michael A Kuskowski; Dennis J Selkoe; Karen K. Hsiao Ashe
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.
Nature neuroscience 2005;8(1):79-84.
2004: Dennis J Selkoe
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases.
Nature cell biology 2004;6(11):1054-61.
2004: Malcolm Leissring; Wesley Farris; Xining Wu; Danos C Christodoulou; Marcia Haigis; Leonard Guarente; Dennis J Selkoe
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.
The Biochemical journal 2004;383(Pt. 3):439-46.
2004: Dominic M Walsh; Dennis J Selkoe
Deciphering the molecular basis of memory failure in Alzheimer's disease.
Neuron 2004;44(1):181-93.
2004: Chianping Ye; Dominic M Walsh; Dennis J Selkoe; Dean Hartley
Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation.
Neuroscience letters 2004;366(3):320-5.
2004: Patrick C Fraering; Wenjuan Ye; Jean-Marc Strub; Georgia Dolios; Matthew J LaVoie; Beth L Ostaszewski; Alain Van Dorsselaer; Rong Wang; Dennis J Selkoe; Michael S Wolfe
Purification and characterization of the human gamma-secretase complex.
Biochemistry 2004;43(30):9774-89.
2004: Cynthia A Lemere; Amy Beierschmitt; Melitza Iglesias; Edward T Spooner; Jeanne K Bloom; Jodi F Leverone; Jessica B Zheng; Timothy Seabrook; Dora Louard; Diana Li; Dennis J Selkoe; Roberta Palmour; Frank R Ervin
Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet.
The American journal of pathology 2004;165(1):283-97.
2004: Dominic M Walsh; Dennis J Selkoe
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration.
Protein and peptide letters 2004;11(3):213-28.
2004: Hideki Hayashi; Nobuyuki Kimura; Haruyasu Yamaguchi; Kazuhiro Hasegawa; Tatsuki Yokoseki; Masao Shibata; Naoki Yamamoto; Makoto Michikawa; Yasuhiro Yoshikawa; Keiji Terao; Katsumi Matsuzaki; Cynthia A Lemere; Dennis J Selkoe; Hironobu Naiki; Katsuhiko Yanagisawa
A seed for Alzheimer amyloid in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4894-902.
2004: Igor Klyubin; Dominic M Walsh; William K Cullen; Julia V Fadeeva; Roger Anwyl; Dennis J Selkoe; Michael J Rowan
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.
The European journal of neuroscience 2004;19(10):2839-46.
2004: Dennis J Selkoe
Alzheimer disease: mechanistic understanding predicts novel therapies.
Annals of internal medicine 2004;140(8):627-38.
2004: Wesley Farris; Stefan Mansourian; Malcolm Leissring; Elizabeth A Eckman; Lars Bertram; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2004: Qinwen Wang; Dominic M Walsh; Michael J Rowan; Dennis J Selkoe; Roger Anwyl
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(13):3370-8.
2004: Patrick C Fraering; Matthew J LaVoie; Wenjuan Ye; Beth L Ostaszewski; W Taylor Kimberly; Dennis J Selkoe; Michael S Wolfe
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Biochemistry 2004;43(2):323-33.
2003: Jay H Chyung; Dennis J Selkoe
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface.
The Journal of biological chemistry 2003;278(51):51035-43.
2003: Malcolm Leissring; Wesley Farris; Alice Y Chang; Dominic M Walsh; Xining Wu; Xiaoyan Sun; Matthew P Frosch; Dennis J Selkoe
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
Neuron 2003;40(6):1087-93.
2003: Dennis J Selkoe
Folding proteins in fatal ways.
Nature 2003;426(6968):900-4.
2003: Ronit Sharon; Ifat Bar-Joseph; Gudrun E Mirick; Charles N Serhan; Dennis J Selkoe
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.
The Journal of biological chemistry 2003;278(50):49874-81.
2003: Dennis J Selkoe
Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman.
Neurochemical research 2003;28(11):1705-13.
2003: Stephanie Baulac; Matthew J LaVoie; W Taylor Kimberly; Jennifer Strahle; Michael S Wolfe; Dennis J Selkoe; Weiming Xia
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Neurobiology of disease 2003;14(2):194-204.
2003: Cynthia A Lemere; Edward T Spooner; John LaFrancois; Brian Malester; Chica Mori; Jodi F Leverone; Yasuji Matsuoka; Jennie W Taylor; Ronald B DeMattos; David M Holtzman; John Clements; Dennis J Selkoe; karen duff
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
2003: Malcolm Leissring; Alice Lu; Margaret M Condron; David B Teplow; Ross L Stein; Wesley Farris; Dennis J Selkoe
Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.
The Journal of biological chemistry 2003;278(39):37314-20.
2003: Matthew J LaVoie; Patrick C Fraering; Beth L Ostaszewski; Wenjuan Ye; W Taylor Kimberly; Michael S Wolfe; Dennis J Selkoe
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The Journal of biological chemistry 2003;278(39):37213-22.
2003: Matthew J LaVoie; Dennis J Selkoe
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
The Journal of biological chemistry 2003;278(36):34427-37.
2003: Chian P Ye; Dennis J Selkoe; Dean Hartley
Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures.
Neurobiology of disease 2003;13(3):177-90.
2003: Alon Monsonego; Victor Zota; Arnon Karni; Jeffrey I Krieger; Amit Bar-Or; Huiyuan Li; Andrew E Budson; Reisa Sperling; Dennis J Selkoe; Howard L Weiner
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.
The Journal of clinical investigation 2003;112(3):415-22.
2003: Marloes Réchards; Weiming Xia; Viola Oorschot; Dennis J Selkoe; Judith Klumperman
Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.
Traffic (Copenhagen, Denmark) 2003;4(8):553-65.
2003: Dominic M Walsh; Julia V Fadeeva; Matthew J LaVoie; Krzysztof Paliga; Simone Eggert; W Taylor Kimberly; Wilma Wasco; Dennis J Selkoe
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Biochemistry 2003;42(22):6664-73.
2003: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6382-7.
2003: Wesley Farris; Stefan Mansourian; Yang Chang; Loren Lindsley; Elizabeth A Eckman; Matthew P Frosch; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe; Suzanne Guenette
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4162-7.
2003: Ronit Sharon; Ifat Bar-Joseph; Matthew P Frosch; Dominic M Walsh; James A Hamilton; Dennis J Selkoe
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.
Neuron 2003;37(4):583-95.
2003: W Taylor Kimberly; William P Esler; Wenjuan Ye; Beth L Ostaszewski; Jun Gao; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2003: Dennis J Selkoe
Toward a remembrance of things past: deciphering Alzheimer disease.
Harvey lectures 2003;99():23-45.
2003: Dennis J Selkoe; Raphael Kopan
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
Annual review of neuroscience 2003;26():565-97.
2003: Dennis J Selkoe; Dale Schenk
Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics.
Annual review of pharmacology and toxicology 2003;43():545-84.
2002: Howard L Weiner; Dennis J Selkoe
Inflammation and therapeutic vaccination in CNS diseases.
Nature 2002;420(6917):879-84.
2002: Dennis J Selkoe
Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
The Journal of clinical investigation 2002;110(10):1375-81.
2002: Dennis J Selkoe
Alzheimer's disease is a synaptic failure.
Science (New York, N.Y.) 2002;298(5594):789-91.
2002: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
The Journal of biological chemistry 2002;277(38):35113-7.
2002: David L Craft; Lawrence M Wein; Dennis J Selkoe
A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma.
Bulletin of mathematical biology 2002;64(5):1011-31.
2002: Dennis J Selkoe
Alzheimer's disease: Conversation with an expert.
Harvard health letter / from Harvard Medical School 2002;27(11):5.
2002: Dominic M Walsh; Igor Klyubin; Julia V Fadeeva; Michael J Rowan; Dennis J Selkoe
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition.
Biochemical Society transactions 2002;30(4):552-7.
2002: John Hardy; Dennis J Selkoe
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science (New York, N.Y.) 2002;297(5580):353-6.
2002: Michael S Wolfe; Dennis J Selkoe
Biochemistry. Intramembrane proteases--mixing oil and water.
Science (New York, N.Y.) 2002;296(5576):2156-7.
2002: Chica Mori; Edward T Spooner; Krystyna E Wisniewsk; Thomas Wisniewski; Haruyasu Yamaguch; Takaom C Saido; Dean R Tolan; Dennis J Selkoe; Cynthia A Lemere
Intraneuronal Abeta42 accumulation in Down syndrome brain.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(2):88-102.
2002: Michael G Schlossmacher; Matthew P Frosch; Wei Ping Gai; Miguel Medina; Nutan Sharma; Lysia Forno; Tomoyo Ochiishi; Hideki Shimura; Ronit Sharon; Nobutaka Hattori; J William Langston; Yoshikuni Mizuno; Bradley T Hyman; Dennis J Selkoe; Kenneth S Kosik
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: William P Esler; Chittaranjan Das; William A Campbell; W Taylor Kimberly; Anna Y Kornilova; Thekla S Diehl; Wenjuan Ye; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: Jimin Zhang; Wenjuan Ye; Rong Wang; Michael S Wolfe; Barry D Greenberg; Dennis J Selkoe
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
The Journal of biological chemistry 2002;277(17):15069-75.
2002: Dominic M Walsh; Igor Klyubin; Julia V Fadeeva; William K Cullen; Roger Anwyl; Michael S Wolfe; Michael J Rowan; Dennis J Selkoe
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Nature 2002;416(6880):535-9.
2002: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2002: Dennis J Selkoe; Marcia B Podlisny
Deciphering the genetic basis of Alzheimer's disease.
Annual review of genomics and human genetics 2002;3():67-99.
2002: H Wang; H Wolosker; John F Morris; Jonathan Pevsner; Solomon H Snyder; Dennis J Selkoe
Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system.
Neuroscience 2002;109(1):1-4.
2002: Dennis J Selkoe
Introducing transglutaminase into the study of Alzheimer's disease. A personal look back.
Neurochemistry international 2002;40(1):13-6.
2001: Cynthia A Lemere; Ruth Maron; Dennis J Selkoe; Howard L Weiner
Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease.
DNA and cell biology 2001;20(11):705-11.
2001: W Taylor Kimberly; J B Zheng; S Y Guénette; Dennis J Selkoe
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
The Journal of biological chemistry 2001;276(43):40288-92.
2001: Dennis J Selkoe
Clearing the brain's amyloid cobwebs.
Neuron 2001;32(2):177-80.
2001: Dennis J Selkoe
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11039-41.
2001: Alon Monsonego; R Maron; Victor Zota; Dennis J Selkoe; Howard L Weiner
Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10273-8.
2001: Ronit Sharon; M S Goldberg; I Bar-Josef; Rebecca A Betensky; Jie Shen; Dennis J Selkoe
alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9110-5.
2001: Hideki Shimura; Michael G Schlossmacher; Nobutaka Hattori; Matthew P Frosch; A Trockenbacher; R Schneider; Yoshikuni Mizuno; Kenneth S Kosik; Dennis J Selkoe
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
Science (New York, N.Y.) 2001;293(5528):263-9.
2001: Dominic M Walsh; Dean Hartley; Margaret M Condron; Dennis J Selkoe; David B Teplow
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.
The Biochemical journal 2001;355(Pt 3):869-77.
2001: Dennis J Selkoe
Alzheimer's disease: genes, proteins, and therapy.
Physiological reviews 2001;81(2):741-66.
2000: Lars Bertram; Deborah Blacker; Kristina Mullin; D Keeney; Jennifer Jones; Sanjay Basu; S Yhu; Melvin G McInnis; Rodney C P Go; K Vekrellis; Dennis J Selkoe; Aleister J Saunders; Rudolph E Tanzi
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Science (New York, N.Y.) 2000;290(5500):2302-3.
2000: Weiming Xia; Beth L Ostaszewski; W Taylor Kimberly; T Rahmati; CL Moore; Michael S Wolfe; Dennis J Selkoe
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiology of disease 2000;7(6 Pt B):673-81.
2000: Youcef Fezoui; Dean Hartley; Dominic M Walsh; Dennis J Selkoe; John J Osterhout; David B Teplow
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
Nature structural biology 2000;7(12):1095-9.
2000: Dennis J Selkoe
The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins.
Neurologic clinics 2000;18(4):903-22.
2000: H Wang; H Wolosker; Jonathan Pevsner; Solomon H Snyder; Dennis J Selkoe
Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammals.
The Journal of endocrinology 2000;167(2):247-52.
2000: V Chesneau; K Vekrellis; Marsha Rich Rosner; Dennis J Selkoe
Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
The Biochemical journal 2000;351 Pt 2():509-16.
2000: Howard L Weiner; Cynthia A Lemere; Ruth Maron; Edward T Spooner; TJ Grenfell; Chica Mori; S Issazadeh; W W Hancock; Dennis J Selkoe
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.
Annals of neurology 2000;48(4):567-79.
2000: CL Moore; D D Leatherwood; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
Journal of medicinal chemistry 2000;43(18):3434-42.
2000: Dominic M Walsh; B P Tseng; R E Rydel; Marcia B Podlisny; Dennis J Selkoe
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain.
Biochemistry 2000;39(35):10831-9.
2000: Youcef Fezoui; Dean Hartley; JD Harper; Bhavana Shivu; Dominic M Walsh; Margaret M Condron; Dennis J Selkoe; Peter T Lansbury; Anthony L Fink; David B Teplow
An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(3):166-78.
2000: Dennis J Selkoe
Imaging Alzheimer's amyloid.
Nature biotechnology 2000;18(8):823-4.
2000: Weiming Xia; William Ray; Beth L Ostaszewski; T Rahmati; W Taylor Kimberly; Michael S Wolfe; Jimin Zhang; Alison Goate; Dennis J Selkoe
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9299-304.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; W Taylor Kimberly; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Thekla S Diehl; CL Moore; J Y Tsai; T Rahmati; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
2000: Dennis J Selkoe; Michael S Wolfe
In search of gamma-secretase: presenilin at the cutting edge.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5690-2.
2000: Dennis J Selkoe
The origins of Alzheimer disease: a is for amyloid.
JAMA : the journal of the American Medical Association 2000;283(12):1615-7.
2000: K Vekrellis; Z Ye; Wei Qiao Qiu; D Walsh; Dean Hartley; V Chesneau; Marsha Rich Rosner; Dennis J Selkoe
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(5):1657-65.
2000: W Taylor Kimberly; Weiming Xia; T Rahmati; Michael S Wolfe; Dennis J Selkoe
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
The Journal of biological chemistry 2000;275(5):3173-8.
2000: Dennis J Selkoe
Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.
Current opinion in neurobiology 2000;10(1):50-7.
2000: S E Stoltzner; TJ Grenfell; Chica Mori; K E Wisniewski; Thomas Wisniewski; Dennis J Selkoe; Cynthia A Lemere
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.
The American journal of pathology 2000;156(2):489-99.
2000: Dennis J Selkoe
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.
Annals of the New York Academy of Sciences 2000;924():17-25.
2000: Cynthia A Lemere; Ruth Maron; Edward T Spooner; TJ Grenfell; Chica Mori; R Desai; W W Hancock; Howard L Weiner; Dennis J Selkoe
Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice.
Annals of the New York Academy of Sciences 2000;920():328-31.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: CL Moore; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.
Annals of the New York Academy of Sciences 2000;920():197-205.
1999: William Ray; M Yao; Jeff S. Mumm; Eric H Schroeter; Paul Saftig; Michael S Wolfe; Dennis J Selkoe; Raphael Kopan; Alison Goate
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
The Journal of biological chemistry 1999;274(51):36801-7.
1999: Dean Hartley; Dominic M Walsh; Chian P Ye; Thekla S Diehl; S Vasquez; Peter M Vassilev; David B Teplow; Dennis J Selkoe
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8876-84.
1999: Dominic M Walsh; Dean Hartley; Y Kusumoto; Youcef Fezoui; Margaret M Condron; Aleksey Lomakin; George B. Benedek; Dennis J Selkoe; David B Teplow
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
The Journal of biological chemistry 1999;274(36):25945-52.
1999: Michael S Wolfe; Joseph E De Los Angeles; Duane D Miller; Weiming Xia; Dennis J Selkoe
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Biochemistry 1999;38(35):11223-30.
1999: Ruth G Perez; Salvador Soriano; J D Hayes; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; X Chen; Gorazd B Stokin; Edward H Koo
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
The Journal of biological chemistry 1999;274(27):18851-6.
1999: Cynthia A Lemere; TJ Grenfell; Dennis J Selkoe
The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome.
The American journal of pathology 1999;155(1):29-37.
1999: Dennis J Selkoe
Translating cell biology into therapeutic advances in Alzheimer's disease.
Nature 1999;399(6738 Suppl):A23-31.
1999: D J Watson; Dennis J Selkoe; David B Teplow
Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.
The Biochemical journal 1999;340 ( Pt 3)():703-9.
1999: Joseph F. Poduslo; Geoffry L Curran; B Sanyal; Dennis J Selkoe
Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier.
Neurobiology of disease 1999;6(3):190-9.
1999: Henry Querfurth; J Jiang; Weiming Xia; Dennis J Selkoe
Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.
Gene 1999;232(1):125-41.
1999: Michael S Wolfe; Weiming Xia; CL Moore; D D Leatherwood; Beth L Ostaszewski; T Rahmati; Isaac O Donkor; Dennis J Selkoe
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry 1999;38(15):4720-7.
1999: Michael S Wolfe; Weiming Xia; Beth L Ostaszewski; Thekla S Diehl; W Taylor Kimberly; Dennis J Selkoe
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature 1999;398(6727):513-7.
1999: P Westermark; S Araki; M D Benson; A S Cohen; Blas Frangione; Colin L Masters; M J Saraiva; J D Sipe; G Husby; R A Kyle; Dennis J Selkoe
Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(1):63-6.
1998: Wei Qiao Qiu; Dominic M Walsh; Z Ye; K Vekrellis; Jimin Zhang; Marcia B Podlisny; Marsha Rich Rosner; A Safavi; Louis B Hersh; Dennis J Selkoe
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
The Journal of biological chemistry 1998;273(49):32730-8.
1998: Harald Steiner; Anja Capell; B Pesold; Martin Citron; P M Kloetzel; Dennis J Selkoe; H Romig; Klaus Mendla; Christian Haass
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
The Journal of biological chemistry 1998;273(48):32322-31.
1998: Weiming Xia; Jimin Zhang; Beth L Ostaszewski; W Taylor Kimberly; Peter Seubert; Edward H Koo; Jie Shen; Dennis J Selkoe
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Biochemistry 1998;37(47):16465-71.
1998: Dennis J Selkoe
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Trends in cell biology 1998;8(11):447-53.
1998: Martin Citron; Christopher B Eckman; Thekla S Diehl; C Corcoran; Beth L Ostaszewski; Weiming Xia; Georges Levesque; Peter St George-Hyslop; Steven G Younkin; Dennis J Selkoe
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: MengQi Xia; Oksana Berezovska; TW Kim; W M Xia; A Liao; Rudolph E Tanzi; Dennis J Selkoe; Bradley T Hyman
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Jimin Zhang; David E Kang; Weiming Xia; M Okochi; Hiroshi Mori; Dennis J Selkoe; Edward H Koo
Subcellular distribution and turnover of presenilins in transfected cells.
The Journal of biological chemistry 1998;273(20):12436-42.
1998: Marcia B Podlisny; Dominic M Walsh; P Amarante; Beth L Ostaszewski; Evelyn R Stimson; John E Maggio; David B Teplow; Dennis J Selkoe
Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.
Biochemistry 1998;37(11):3602-11.
1998: Anja Capell; J Grünberg; B Pesold; A Diehlmann; Martin Citron; Ralph A. Nixon; Konrad Beyreuther; Dennis J Selkoe; Christian Haass
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Christian Haass; Dennis J Selkoe
Alzheimer's disease. A technical KO of amyloid-beta peptide.
Nature 1998;391(6665):339-40.
1998: Michael S Wolfe; Martin Citron; Thekla S Diehl; Weiming Xia; Isaac O Donkor; Dennis J Selkoe
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Journal of medicinal chemistry 1998;41(1):6-9.
1997: D J Watson; A D Lander; Dennis J Selkoe
Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.
The Journal of biological chemistry 1997;272(50):31617-24.
1997: Henry Querfurth; J Jiang; Jonathan D Geiger; Dennis J Selkoe
Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells.
Journal of neurochemistry 1997;69(4):1580-91.
1997: Dennis J Selkoe
Images in neuroscience. Alzheimer's disease: from genes to pathogenesis.
The American journal of psychiatry 1997;154(9):1198.
1997: Weiming Xia; Jimin Zhang; Ruth G Perez; Edward H Koo; Dennis J Selkoe
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8208-13.
1997: Jie Shen; Roderick T Bronson; D F Chen; W Xia; Dennis J Selkoe; Susumu Tonegawa
Skeletal and CNS defects in Presenilin-1-deficient mice.
Cell 1997;89(4):629-39.
1997: Jochen Walter; J Grünberg; Anja Capell; B Pesold; A Schindzielorz; Martin Citron; Klaus Mendla; Peter St George-Hyslop; Gerd Multhaup; Dennis J Selkoe; Christian Haass
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: Weiming Xia; Jimin Zhang; Dora Kholodenko; Martin Citron; Marcia B Podlisny; David B Teplow; Christian Haass; Peter Seubert; Edward H Koo; Dennis J Selkoe
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
The Journal of biological chemistry 1997;272(12):7977-82.
1997: Wei Qiao Qiu; Z Ye; Dora Kholodenko; Peter Seubert; Dennis J Selkoe
Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells.
The Journal of biological chemistry 1997;272(10):6641-6.
1997: T Yamazaki; Edward H Koo; Dennis J Selkoe
Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(3):1004-10.
1997: Dennis J Selkoe
Alzheimer's disease: genotypes, phenotypes, and treatments.
Science (New York, N.Y.) 1997;275(5300):630-1.
1997: Jochen Walter; Anja Capell; A Y Hung; H Langen; M Schnölzer; Gopal Thinakaran; Sangram S Sisodia; Dennis J Selkoe; Christian Haass
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: Joseph F. Poduslo; Geoffry L Curran; J J Haggard; A L Biere; Dennis J Selkoe
Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier.
Neurobiology of disease 1997;4(1):27-34.
1997: Marcia B Podlisny; Martin Citron; P Amarante; R Sherrington; Weiming Xia; Jimin Zhang; Thekla S Diehl; Georges Levesque; Paul E Fraser; Christian Haass; Edward H Koo; Peter Seubert; Peter St George-Hyslop; David B Teplow; Dennis J Selkoe
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1997: Martin Citron; David Westaway; Weiming Xia; G Carlson; Thekla S Diehl; Georges Levesque; Kelly Johnson-Wood; Mike Lee; Peter Seubert; A Davis; Dora Kholodenko; Ruth Motter; R Sherrington; B Perry; H Yao; R Strome; I Lieberburg; Johanna M Rommens; S Kim; Dale Schenk; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Nature medicine 1997;3(1):67-72.
1996: M Lalowski; Adam A Golabek; Cynthia A Lemere; Dennis J Selkoe; Henryk M Wisniewski; Ronald C Beavis; Blas Frangione; Thomas Wisniewski
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
The Journal of biological chemistry 1996;271(52):33623-31.
1996: A L Biere; Beth L Ostaszewski; Evelyn R Stimson; Bradley T Hyman; John E Maggio; Dennis J Selkoe
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma.
The Journal of biological chemistry 1996;271(51):32916-22.
1996: Martin Citron; Thekla S Diehl; G Gordon; Anja Leona Biere; Peter Seubert; Dennis J Selkoe
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13170-5.
1996: Jochen Walter; Anja Capell; J Grünberg; B Pesold; A Schindzielorz; R Prior; Marcia B Podlisny; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe; Christian Haass
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Molecular medicine (Cambridge, Mass.) 1996;2(6):673-91.
1996: AP Doan; Gopal Thinakaran; David R Borchelt; Hilda H Slunt; T Ratovitsky; M Podlisny; Dennis J Selkoe; M Seeger; Sam Gandy; Donald L Price; Sangram S Sisodia
Protein topology of presenilin 1.
Neuron 1996;17(5):1023-30.
1996: Cynthia A Lemere; Francisco Lopera; Kenneth S Kosik; Corinne Lendon; Jorge E Ossa; Takaomi C Saido; Haruyasu Yamaguchi; A Ruiz; A Martinez; L Madrigal; L Hincapie; JC Arango; D C Anthony; Edward H Koo; Alison Goate; Dennis J Selkoe; J C Arango
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Noel Y Calingasan; Sam Gandy; H Baker; KF Sheu; Jonathan D. Smith; Bruce Lamb; John D Gearhart; Joseph Buxbaum; C Harper; Dennis J Selkoe; Donald L Price; Sangram S Sisodia; Gary Gibson
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
The American journal of pathology 1996;149(3):1063-71.
1996: Dennis J Selkoe
Amyloid beta-protein and the genetics of Alzheimer's disease.
The Journal of biological chemistry 1996;271(31):18295-8.
1996: Donalyn Scheuner; Christopher B Eckman; M Jensen; X Song; Martin Citron; N Suzuki; Thomas D Bird; John Hardy; Michael Hutton; Walter A Kukull; Eric B Larson; Ephrat Levy-Lahad; Matti Viitanen; Elaine Peskind; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; Rudolph E Tanzi; Wilma Wasco; Lars Lannfelt; Dennis J Selkoe; Steven G Younkin
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Brian John Cummings; T Satou; Elizabeth Head; Norton W Milgram; Gregory M. Cole; Mary J Savage; M B Podlisny; Dennis J Selkoe; R Siman; Benjamin D Greenberg; Carl W Cotman
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.
Neurobiology of aging 1996;17(4):653-9.
1996: Martin Citron; Thekla S Diehl; Anja Capell; Christian Haass; David B Teplow; Dennis J Selkoe
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Neuron 1996;17(1):171-9.
1996: T Yamazaki; Edward H Koo; Dennis J Selkoe
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.
Journal of cell science 1996;109 ( Pt 5)():999-1008.
1996: Edward H Koo; Sharon Squazzo; Dennis J Selkoe; C H Koo
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.
Journal of cell science 1996;109 ( Pt 5)():991-8.
1996: Akira Tamaoka; R Endoh; Shin'ichi Shoji; H Takahashi; K Hirokawa; David B Teplow; Dennis J Selkoe; Hiroshi Mori
Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Neurobiology of aging 1996;17(3):405-14.
1996: Wei Qiao Qiu; W Borth; Z Ye; Christian Haass; David B Teplow; Dennis J Selkoe
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.
The Journal of biological chemistry 1996;271(14):8443-51.
1996: DT Stephenson; Cynthia A Lemere; Dennis J Selkoe; J A Clemens
Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain.
Neurobiology of disease 1996;3(1):51-63.
1996: Cynthia A Lemere; J K Blusztajn; Haruyasu Yamaguchi; Thomas Wisniewski; Takaomi C Saido; Dennis J Selkoe
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1996: Dennis J Selkoe; T Yamazaki; Martin Citron; Marcia B Podlisny; Edward H Koo; David B Teplow; Christian Haass
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.
Annals of the New York Academy of Sciences 1996;777():57-64.
1996: Dennis J Selkoe
Cell biology of the beta-amyloid precursor protein and the genetics of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():587-96.
1995: Christian Haass; Cynthia A Lemere; Anja Capell; Martin Citron; Peter Seubert; Dale Schenk; Lars Lannfelt; Dennis J Selkoe
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine 1995;1(12):1291-6.
1995: J S Munger; Christian Haass; Cynthia A Lemere; Guo-Ping Shi; W S Wong; David B Teplow; Dennis J Selkoe; Harold A Chapman
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
The Biochemical journal 1995;311 ( Pt 1)():299-305.
1995: Dennis J Selkoe
Alzheimer's amyloid of another flavour.
Nature medicine 1995;1(10):998-9.
1995: Steven M Greenberg; Wei Qiao Qiu; Dennis J Selkoe; A Ben-Itzhak; Kenneth S Kosik
Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.
Neuroscience letters 1995;198(1):52-6.
1995: Dennis J Selkoe
Alzheimer's disease. Missense on the membrane.
Nature 1995;375(6534):734-5.
1995: A L Biere; Beth L Ostaszewski; H Zhao; S Gillespie; Steven G Younkin; Dennis J Selkoe
Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing.
Neurobiology of disease 1995;2(3):177-87.
1995: Marcia B Podlisny; Beth L Ostaszewski; Sharon Squazzo; Edward H Koo; R E Rydell; David B Teplow; Dennis J Selkoe
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.
The Journal of biological chemistry 1995;270(16):9564-70.
1995: T Yamazaki; Dennis J Selkoe; Edward H Koo
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.
The Journal of cell biology 1995;129(2):431-42.
1995: Cynthia A Lemere; J S Munger; Guo-Ping Shi; L Natkin; Christian Haass; Harold A Chapman; Dennis J Selkoe
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
The American journal of pathology 1995;146(4):848-60.
1995: Christian Haass; Anja Capell; Martin Citron; David B Teplow; Dennis J Selkoe
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(11):6186-92.
1995: Wei Qiao Qiu; Adriana Ferreira; C Miller; Edward H Koo; Dennis J Selkoe
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(3 Pt 2):2157-67.
1995: C Haas; A Y Hung; Martin Citron; David B Teplow; Dennis J Selkoe
beta-Amyloid, protein processing and Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):398-402.
1995: Martin Citron; David B Teplow; Dennis J Selkoe
Generation of amyloid beta protein from its precursor is sequence specific.
Neuron 1995;14(3):661-70.
1995: Christian Haass; Edward H Koo; Anja Capell; David B Teplow; Dennis J Selkoe
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
The Journal of cell biology 1995;128(4):537-47.
1995: Henry Querfurth; E M Wijsman; Peter St George-Hyslop; Dennis J Selkoe
Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.
Brain research. Molecular brain research 1995;28(2):319-37.
1994: Martin Citron; C Vigo-Pelfrey; David B Teplow; C Miller; Dale Schenk; J Johnston; Bengt Winblad; N Venizelos; Lars Lannfelt; Dennis J Selkoe
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11993-7.
1994: Dennis J Selkoe
Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease.
Current opinion in neurobiology 1994;4(5):708-16.
1994: Dennis J Selkoe
Alzheimer's disease: a central role for amyloid.
Journal of neuropathology and experimental neurology 1994;53(5):438-47.
1994: Steven M Greenberg; Edward H Koo; Dennis J Selkoe; Wei Qiao Qiu; Kenneth S Kosik
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7104-8.
1994: Christian Haass; A Y Hung; Dennis J Selkoe; David B Teplow
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
The Journal of biological chemistry 1994;269(26):17741-8.
1994: Henry Querfurth; Dennis J Selkoe
Calcium ionophore increases amyloid beta peptide production by cultured cells.
Biochemistry 1994;33(15):4550-61.
1994: Nöelle Bons; N Mestre; K Ritchie; A Petter; M Podlisny; Dennis J Selkoe
Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus.
Neurobiology of aging 1994;15(2):215-20.
1994: Christian Haass; Edward H Koo; David B Teplow; Dennis J Selkoe
Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1564-8.
1994: A Y Hung; Dennis J Selkoe
Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein.
The EMBO journal 1994;13(3):534-42.
1994: Valerie Askanas; W King Engel; M Bilak; RB Alvarez; Dennis J Selkoe
Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.
The American journal of pathology 1994;144(1):177-87.
1994: Dennis J Selkoe
Normal and abnormal biology of the beta-amyloid precursor protein.
Annual review of neuroscience 1994;17():489-517.
1994: Lawrence M Maness; WA Banks; M B Podlisny; Dennis J Selkoe; Abba J Kastin
Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier.
Life sciences 1994;55(21):1643-50.
1994: Dennis J Selkoe
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.
Annual review of cell biology 1994;10():373-403.
1994: Dennis J Selkoe
Alzheimer's disease beyond 1994: the path to therapeutics.
Neurobiology of aging 1994;15 Suppl 2():S131-3.
1993: Christian Haass; Dennis J Selkoe
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.
Cell 1993;75(6):1039-42.
1993: A Y Hung; Christian Haass; Roger M Nitsch; Wei Qiao Qiu; Martin Citron; Richard Jay Wurtman; John H Growdon; Dennis J Selkoe
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
The Journal of biological chemistry 1993;268(31):22959-62.
1993: Martin Citron; Christian Haass; Dennis J Selkoe
Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Neurobiology of aging 1993;14(6):571-3.
1993: Dennis J Selkoe
Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease.
Trends in neurosciences 1993;16(10):403-9.
1993: Christian Haass; A Y Hung; Michael G Schlossmacher; Tilman Oltersdorf; David B Teplow; Dennis J Selkoe
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Annals of the New York Academy of Sciences 1993;695():109-16.
1993: Edward H Koo; L Park; Dennis J Selkoe
Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4748-52.
1993: M R Hanley; Dennis J Selkoe
Alzheimer's disease. Amyloid precursor on the G(o)
Nature 1993;362(6415):14-5.
1993: Christian Haass; A Y Hung; Michael G Schlossmacher; David B Teplow; Dennis J Selkoe
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
The Journal of biological chemistry 1993;268(5):3021-4.
1993: Marcia B Podlisny; DT Stephenson; M P Frosch; D R Tolan; I Lieberburg; JA Clemens; Dennis J Selkoe
Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.
The American journal of pathology 1993;142(1):17-24.
1992: Martin Citron; Tilman Oltersdorf; Christian Haass; Lisa McConlogue; A Y Hung; Peter Seubert; C Vigo-Pelfrey; I Lieberburg; Dennis J Selkoe
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature 1992;360(6405):672-4.
1992: Paul E Fraser; J T Nguyen; H Inouye; W K Surewicz; Dennis J Selkoe; M B Podlisny; Daniel A Kirschner
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.
Biochemistry 1992;31(44):10716-23.
1992: A Y Hung; Edward H Koo; Christian Haass; Dennis J Selkoe
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9439-43.
1992: Dennis J Selkoe
Aging brain, aging mind.
Scientific American 1992;267(3):134-42.
1992: Marcia B Podlisny; DT Stephenson; M P Frosch; I Lieberburg; JA Clemens; Dennis J Selkoe
Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex.
Neurobiology of aging 1992;13(5):561-7.
1992: Hiroshi Mori; Koji Takio; M Ogawara; Dennis J Selkoe
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
The Journal of biological chemistry 1992;267(24):17082-6.
1992: Haruyasu Yamaguchi; T Yamazaki; Cynthia A Lemere; M P Frosch; Dennis J Selkoe
Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.
The American journal of pathology 1992;141(1):249-59.
1992: Christian Haass; Edward H Koo; A Mellon; A Y Hung; Dennis J Selkoe
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Nature 1992;357(6378):500-3.
1992: Michael G Schlossmacher; Beth L Ostaszewski; L I Hecker; A Celi; Christian Haass; D Chin; I Lieberburg; B C Furie; B Furie; Dennis J Selkoe
Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Neurobiology of aging 1992;13(3):421-34.
1992: A Tamaoka; Rajesh N. Kalaria; I Lieberburg; Dennis J Selkoe
Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1345-9.
1992: todd golde; Steven Estus; Linda Younkin; Dennis J Selkoe; Steven G Younkin
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science (New York, N.Y.) 1992;255(5045):728-30.
1992: C L Joachim; Dennis J Selkoe
The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease.
Alzheimer disease and associated disorders 1992;6(1):7-34.
1991: Dennis J Selkoe
Alzheimer's disease. In the beginning...
Nature 1991;354(6353):432-3.
1991: Christian Haass; A Y Hung; Dennis J Selkoe
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(12):3783-93.
1991: Dennis J Selkoe
Amyloid protein and Alzheimer's disease.
Scientific American 1991;265(5):68-71, 74-6, 78.
1991: Marcia B Podlisny; D R Tolan; Dennis J Selkoe
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
The American journal of pathology 1991;138(6):1423-35.
1991: Dennis J Selkoe
The molecular pathology of Alzheimer's disease.
Neuron 1991;6(4):487-98.
1991: Catherine Joachim; D Games; J Morris; P Ward; D Frenkel; Dennis J Selkoe
Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.
The American journal of pathology 1991;138(2):373-84.
1990: S Bodmer; M B Podlisny; Dennis J Selkoe; I Heid; Adriano Fontana
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Biochemical and biophysical research communications 1990;171(2):890-7.
1990: Dennis J Selkoe
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
Science (New York, N.Y.) 1990;248(4959):1058-60.
1990: Hiroshi Mori; Dennis J Selkoe
[Biochemistry of Alzheimer's disease].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(7 Suppl):1353-61.
1990: Marcia B Podlisny; ANDREW MAMMEN; Michael G Schlossmacher; M R Palmert; Steven G Younkin; Dennis J Selkoe
Detection of soluble forms of the beta-amyloid precursor protein in human plasma.
Biochemical and biophysical research communications 1990;167(3):1094-101.
1990: Dennis J Selkoe; Marcia B Podlisny; A Gronbeck; ANDREW MAMMEN; Kenneth S Kosik
Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease.
Advances in neurology 1990;51():171-9.
1989: M R Palmert; Sandra L Siedlak; Marcia B Podlisny; Barry D Greenberg; Earl R Shelton; H W Chan; M Usiak; Dennis J Selkoe; George Perry; Steven G Younkin
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Biochemical and biophysical research communications 1989;165(1):182-8.
1989: S Itagaki; Patrick L McGeer; Haruhiko Akiyama; S Zhu; Dennis J Selkoe
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.
Journal of neuroimmunology 1989;24(3):173-82.
1989: Catherine Joachim; Hiroshi Mori; Dennis J Selkoe
Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease.
Nature 1989;341(6239):226-30.
1989: Dennis J Selkoe
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease.
Neurobiology of aging 1989;10(5):387-95.
1989: Dennis J Selkoe
Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease.
Cell 1989;58(4):611-2.
1989: Catherine Joachim; J H Morris; Dennis J Selkoe
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.
The American journal of pathology 1989;135(2):309-19.
1989: M R Palmert; Marcia B Podlisny; D S Witker; Tilman Oltersdorf; Linda Younkin; Dennis J Selkoe; Steven G Younkin
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6338-42.
1989: C L Joachim; Dennis J Selkoe
Amyloid protein in Alzheimer's disease.
Journal of gerontology 1989;44(4):B77-82.
1989: Dennis J Selkoe
Aging, amyloid, and Alzheimer's disease.
The New England journal of medicine 1989;320(22):1484-7.
1989: J S Whitson; Dennis J Selkoe; Carl W Cotman
Amyloid beta protein enhances the survival of hippocampal neurons in vitro.
Science (New York, N.Y.) 1989;243(4897):1488-90.
1989: Carmela Abraham; Dennis J Selkoe; H Potter; Donald L Price; L C Cork
Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits.
Neuroscience 1989;32(3):715-20.
1989: Dennis J Selkoe
Biochemistry of altered brain proteins in Alzheimer's disease.
Annual review of neuroscience 1989;12():463-90.
1989: L S Forno; L F Eng; Dennis J Selkoe
Pick bodies in the locus ceruleus.
Acta neuropathologica 1989;79(1):10-7.
1989: Dennis J Selkoe
The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease.
Annals of medicine 1989;21(2):73-6.
1988: Catherine Joachim; L K Duffy; J H Morris; Dennis J Selkoe
Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.
Brain research 1988;474(1):100-11.
1988: L C Cork; R E Powers; Dennis J Selkoe; Peter Davies; J J Geyer; Donald L Price
Neurofibrillary tangles and senile plaques in aged bears.
Journal of neuropathology and experimental neurology 1988;47(6):629-41.
1988: M R Palmert; Marcia B Podlisny; D S Witker; Tilman Oltersdorf; Linda Younkin; Dennis J Selkoe; Steven G Younkin
Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques.
Biochemical and biophysical research communications 1988;156(1):432-7.
1988: Dennis J Selkoe; Marcia B Podlisny; Catherine Joachim; E A Vickers; Gloria Lee; Lawrence C Fritz; Tilman Oltersdorf
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7341-5.
1988: Catherine Joachim; J H Morris; Dennis J Selkoe
Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases.
Annals of neurology 1988;24(1):50-6.
1988: N Nukina; Kenneth S Kosik; Dennis J Selkoe
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain.
Neuroscience letters 1988;87(3):240-6.
1988: Carmela Abraham; Dennis J Selkoe; H Potter
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
Cell 1988;52(4):487-501.
1988: David G Munoz; C Greene; Daniel P Perl; Dennis J Selkoe
Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.
Journal of neuropathology and experimental neurology 1988;47(1):9-18.
1987: Catherine Joachim; J H Morris; Dennis J Selkoe; Kenneth S Kosik
Tau epitopes are incorporated into a range of lesions in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1987;46(6):611-22.
1987: Marcia B Podlisny; Gloria Lee; Dennis J Selkoe
Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):669-71.
1987: Daniel A Kirschner; H Inouye; L K Duffy; A Sinclair; M Lind; Dennis J Selkoe
Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6953-7.
1987: Catherine Joachim; J H Morris; Kenneth S Kosik; Dennis J Selkoe
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.
Annals of neurology 1987;22(4):514-20.
1987: David Eidelberg; A Sotrel; Catherine Joachim; Dennis J Selkoe; A Forman; W W Pendlebury; Daniel P Perl
Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity.
Brain : a journal of neurology 1987;110 ( Pt 4)():993-1013.
1987: N Nukina; Kenneth S Kosik; Dennis J Selkoe
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3415-9.
1987: Dennis J Selkoe; D S Bell; M B Podlisny; Donald L Price; L C Cork
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Science (New York, N.Y.) 1987;235(4791):873-7.
1986: Dennis J Selkoe
Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?
Neurobiology of aging 1986;7(6):425-32.
1986: R L Neve; Dennis J Selkoe; D M Kurnit; Kenneth S Kosik
A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle.
Brain research 1986;387(2):193-6.
1986: C G Rasool; Clive Svendsen; Dennis J Selkoe
Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease.
Annals of neurology 1986;20(4):482-8.
1986: Dennis J Selkoe; Carmela Abraham; M B Podlisny; L K Duffy
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.
Journal of neurochemistry 1986;46(6):1820-34.
1986: Kenneth S Kosik; C L Joachim; Dennis J Selkoe
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):4044-8.
1986: George Perry; Dennis J Selkoe; B R Block; D Stewart; L Autilio-Gambetti; P Gambetti
Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments.
Journal of neuropathology and experimental neurology 1986;45(2):161-8.
1986: Dennis J Selkoe; Carmela Abraham
Isolation of paired helical filaments and amyloid fibers from human brain.
Methods in enzymology 1986;134():388-404.
1986: Daniel A Kirschner; Carmela Abraham; Dennis J Selkoe
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):503-7.
1986: Kenneth S Kosik; S Bakalis; L Galibert; Dennis J Selkoe; L K Duffy
Age-related modifications of MAP-2.
Annals of the New York Academy of Sciences 1986;466():420-2.
1986: Kenneth S Kosik; S F Bakalis; Dennis J Selkoe; M W Pierce; L K Duffy
High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions.
Journal of neuroscience research 1986;15(4):543-51.
1985: C G Rasool; Dennis J Selkoe
Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease.
The New England journal of medicine 1985;312(11):700-5.
1985: Dennis J Selkoe; Carmela Abraham; C G Rasool; A McCluskey; Kenneth S Kosik; L K Duffy
Paired helical filaments in human neurons: relationship to neurofilaments.
Annals of the New York Academy of Sciences 1985;455():583-96.
1985: Kenneth S Kosik; A H McCluskey; F X Walsh; Dennis J Selkoe
Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport.
Neurochemical pathology 1985;3(2):99-108.
1984: Kenneth S Kosik; L K Duffy; M M Dowling; Carmela Abraham; A McCluskey; Dennis J Selkoe
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7941-5.
1984: C G Rasool; Dennis J Selkoe
Alzheimer's disease: exposure of neurofilament immunoreactivity in SDS-insoluble paired helical filaments.
Brain research 1984;322(1):194-8.
1984: Kenneth S Kosik; Dennis J Selkoe; V Sapirstein
Possible modifications of vimentin following acquisition of triton insolubility.
Biochemistry international 1984;9(4):483-90.
1984: C G Rasool; Carmela Abraham; Brian H Anderton; M Haugh; J Kahn; Dennis J Selkoe
Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies.
Brain research 1984;310(2):249-60.
1984: A Bignami; Dennis J Selkoe; D Dahl
Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex.
Acta neuropathologica 1984;64(3):243-50.
1983: Yasuo Ihara; Carmela Abraham; Dennis J Selkoe
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.
Nature 1983;304(5928):727-30.
1983: Kenneth S Kosik; Walter G Bradley; Paul F Good; C G Rasool; Dennis J Selkoe
Cholinergic function in lumbar aluminum myelopathy.
Journal of neuropathology and experimental neurology 1983;42(4):365-75.
1982: Kenneth S Kosik; J M Gilbert; Dennis J Selkoe; P Strocchi
Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis.
Journal of neurochemistry 1982;39(6):1529-38.
1982: Dennis J Selkoe; Carmela Abraham; Yasuo Ihara
Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(19):6070-4.
1982: Dennis J Selkoe; F J Salazar; Carmela Abraham; Kenneth S Kosik
Huntington's disease: changes in striatal proteins reflect astrocytic gliosis.
Brain research 1982;245(1):117-25.
1982: Dennis J Selkoe; Yasuo Ihara; F J Salazar
Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.
Science (New York, N.Y.) 1982;215(4537):1243-5.
1982: D Dahl; Dennis J Selkoe; R T Pero; A Bignami
Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(1):113-9.
1981: A C Breuer; H Cuervo; Dennis J Selkoe
Hyperpathia and sensory level due to parietal lobe arteriovenous malformation.
Archives of neurology 1981;38(11):722-4.
1981: Dennis J Selkoe; B A Brown; F J Salazar; Charles Marotta
Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.
Annals of neurology 1981;10(5):429-36.
1981: L F Borges; Mark Hallett; Dennis J Selkoe; K Welch
The anterior tarsal tunnel syndrome. Report of two cases.
Journal of neurosurgery 1981;54(1):89-92.
1981: Stephen Rothenberg; Dennis J Selkoe
Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements.
Psychopharmacology 1981;74(3):237-40.
1981: Stephen Rothenberg; Dennis J Selkoe
Specific oculomotor deficit after diazepam. I. Saccadic eye movements.
Psychopharmacology 1981;74(3):232-6.
1980: Dennis J Selkoe
Altered protein composition of isolated human cortical neurons in Alzheimer disease.
Annals of neurology 1980;8(5):468-78.
1980: S Rothenberg; S Schottenfeld; Dennis J Selkoe; K Gross
Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements.
Psychopharmacology 1980;67(3):229-34.
1980: S Rothenberg; S Schottenfeld; K Gross; Dennis J Selkoe
Specific oculomotor deficit after acute methadone. I. Saccadic eye movements.
Psychopharmacology 1980;67(3):221-7.
1979: Dennis J Selkoe
Nucleotide dependence of successive cycles of tubulin assembly.
Brain research 1979;172(2):382-6.
1979: Dennis J Selkoe; R K Liem; Shu-Hui C. Yen; Michael L. Shelanski
Biochemical and immunological characterization of neurofilaments in experimental neurofibrillary degeneration induced by aluminum.
Brain research 1979;163(2):235-52.
1979: Dennis J Selkoe; R E Myers
Neurologic and cardiovascular effects of hypotension in the monkey.
Stroke; a journal of cerebral circulation 1979;10(2):147-57.
1979: R K Liem; Dennis J Selkoe; Shu-Hui C. Yen; G Salomon; Michael L. Shelanski
New insights on the composition of neurofilaments.
Research publications - Association for Research in Nervous and Mental Disease 1979;57():145-52.
1979: Dennis J Selkoe
Disease-related protein changes in purified neurons from Alzheimer's and Huntington's diseases.
Transactions of the American Neurological Association 1979;104():70-4.
1978: Dennis J Selkoe; L Luckenbill-Edds; Michael L. Shelanski
Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives.
Journal of neuropathology and experimental neurology 1978;37(6):768-89.
1975: L P Levitt; Dennis J Selkoe; B Frankenfield; W Schoene
Pure motor hemiplegia secondary to brain-stem tumour.
Journal of neurology, neurosurgery, and psychiatry 1975;38(12):1240-3.
1970: H M Shein; A Britva; H H Hess; Dennis J Selkoe
Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA.
Brain research 1970;19(3):497-501.
1969: Dennis J Selkoe
Familial hyperprolinemia and mental retardation. A second metabolic type.
Neurology 1969;19(5):494-502.