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Dennis Selkoe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Alzheimer Disease

Chemicals & Drugs

Anatomy

Living Beings

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Molecular Sequence Data

Physiology

Transfection

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Co-Publications
Name
33
Walsh, Dominic
33
Wolfe, Michael
29
Haass, Christian
26
Xia, Weiming
25
Teplow, David
25
Ostaszewski, Beth
21
Podlisny, Marcia
21
Kosik, Kenneth
20
Koo, Edward
20
Lemere, Cynthia
20
Citron, Martin
18
Kimberly, Taylor
14
Diehl, Thekla
14
Ye, Wenjuan
12
LaVoie, Matthew

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Publications

TOP 3
Shankar Ganesh M; Leissring Malcolm A; Adame Anthony; Sun Xiaoyan; Spooner Edward; Masliah Eliezer; Selkoe Dennis J; Lemere Cynthia A; Walsh Dominic M
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Okereke Olivia I; Xia Weiming; Selkoe Dennis J; Grodstein Francine
Ten-year change in plasma amyloid beta levels and late-life cognitive decline.
Rappley Irit; Myers David S; Milne Stephen B; Ivanova Pavlina T; Lavoie Matthew J; Brown H Alex; Selkoe Dennis J
Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.

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All Publications

2009: Shankar Ganesh M; Leissring Malcolm A; Adame Anthony; Sun Xiaoyan; Spooner Edward; Masliah Eliezer; Selkoe Dennis J; Lemere Cynthia A; Walsh Dominic M
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Neurobiology of disease 2009;36(2):293-302.
2009: Okereke Olivia I; Xia Weiming; Selkoe Dennis J; Grodstein Francine
Ten-year change in plasma amyloid beta levels and late-life cognitive decline.
Archives of neurology 2009;66(10):1247-53.
2009: Rappley Irit; Myers David S; Milne Stephen B; Ivanova Pavlina T; Lavoie Matthew J; Brown H Alex; Selkoe Dennis J
Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.
Journal of neurochemistry 2009;111(1):15-25.
2009: Zota Victor; Nemirovsky Anna; Baron Rona; Fisher Yair; Selkoe Dennis J; Altmann Daniel M; Weiner Howard L; Monsonego Alon
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3522-30.
2009: Sperling Reisa A; Laviolette Peter S; O'Keefe Kelly; O'Brien Jacqueline; Rentz Dorene M; Pihlajamaki Maija; Marshall Gad; Hyman Bradley T; Selkoe Dennis J; Hedden Trey; Buckner Randy L; Becker J Alex; Johnson Keith A
Amyloid deposition is associated with impaired default network function in older persons without dementia.
Neuron 2009;63(2):178-88.
2009: Li Shaomin; Hong Soyon; Shepardson Nina E; Walsh Dominic M; Shankar Ganesh M; Selkoe Dennis
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.
Neuron 2009;62(6):788-801.
2009: Minogue Aedín M; Stubbs Adam K; Frigerio Carlo Sala; Boland Barry; Fadeeva Julia V; Tang Jordan; Selkoe Dennis J; Walsh Dominic M
gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.
Brain research 2009;1262():89-99.
2009: Li Huilin; Wolfe Michael S; Selkoe Dennis J
Toward structural elucidation of the gamma-secretase complex.
Structure (London, England : 1993) 2009;17(3):326-34.
2009: Weihofen Andreas; Thomas Kelly Jean; Ostaszewski Beth L; Cookson Mark R; Selkoe Dennis J
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry 2009;48(9):2045-52.
2009: Okereke Olivia I; Xia Weiming; Irizarry Michael C; Sun Xiaoyan; Qiu Wei Q; Fagan Anne M; Mehta Pankaj D; Hyman Bradley T; Selkoe Dennis J; Grodstein Francine
Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Journal of Alzheimer's disease : JAD 2009;16(2):277-85.
2009: Xia Weiming; Yang Ting; Shankar Ganesh; Smith Imelda M; Shen Yong; Walsh Dominic M; Selkoe Dennis J
A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Archives of neurology 2009;66(2):190-9.
2009: Rappley Irit; Gitler Aaron D; Selvy Paige E; LaVoie Matthew J; Levy Bruce D; Brown H Alex; Lindquist Susan; Selkoe Dennis J
Evidence that alpha-synuclein does not inhibit phospholipase D.
Biochemistry 2009;48(5):1077-83.
2009: Ben Gedalya Tziona; Loeb Virginie; Israeli Eitan; Altschuler Yoram; Selkoe Dennis J; Sharon Ronit
Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling.
Traffic (Copenhagen, Denmark) 2009;10(2):218-34.
2009: Okereke Olivia I; Selkoe Dennis J; Pollak Michael N; Stampfer Meir J; Hu Frank B; Hankinson Susan E; Grodstein Francine
A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation.
International journal of geriatric psychiatry 2009;24(2):177-82.
2009: Osenkowski Pamela; Li Hua; Ye Wenjuan; Li Dongyang; Aeschbach Lorene; Fraering Patrick C; Wolfe Michael S; Selkoe Dennis J; Li Huilin
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.
Journal of molecular biology 2009;385(2):642-52.
2009: Cabrol Christelle; Huzarska Malwina A; Dinolfo Christopher; Rodriguez Maria C; Reinstatler Lael; Ni Jake; Yeh Li-An; Cuny Gregory D; Stein Ross L; Selkoe Dennis J; Leissring Malcolm A
Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.
PloS one 2009;4(4):e5274.
2008: Hemming Matthew L; Elias Joshua E; Gygi Steven P; Selkoe Dennis J
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.
PLoS biology 2008;6(10):e257.
2008: Betts Vicki; Leissring Malcolm A; Dolios Georgia; Wang Rong; Selkoe Dennis J; Walsh Dominic M
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.
Neurobiology of disease 2008;31(3):442-50.
2008: Selkoe Dennis J
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.
Behavioural brain research 2008;192(1):106-13.
2008: Shankar Ganesh M; Li Shaomin; Mehta Tapan H; Garcia-Munoz Amaya; Shepardson Nina E; Smith Imelda; Brett Francesca M; Farrell Michael A; Rowan Michael J; Lemere Cynthia A; Regan Ciaran M; Walsh Dominic M; Sabatini Bernardo L; Selkoe Dennis J
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Nature medicine 2008;14(8):837-42.
2008: Osenkowski Pamela; Ye Wenjuan; Wang Rong; Wolfe Michael S; Selkoe Dennis J
Direct and potent regulation of gamma-secretase by its lipid microenvironment.
The Journal of biological chemistry 2008;283(33):22529-40.
2008: Neant-Fery Marie; Garcia-Ordoñez Rubén D; Logan Todd P; Selkoe Dennis J; Li Lilin; Reinstatler Lael; Leissring Malcolm A
Molecular basis for the thiol sensitivity of insulin-degrading enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9582-7.
2008: Okereke Olivia I; Pollak Michael N; Hu Frank B; Hankinson Susan E; Selkoe Dennis J; Grodstein Francine
Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes.
Psychoneuroendocrinology 2008;33(4):455-61.
2008: Klyubin Igor; Betts Vicki; Welzel Alfred T; Blennow Kaj; Zetterberg Henrik; Wallin Anders; Lemere Cynthia A; Cullen William K; Peng Ying; Wisniewski Thomas; Selkoe Dennis J; Anwyl Roger; Walsh Dominic M; Rowan Michael J
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4231-7.
2008: Nazer Babak; Hong Soyon; Selkoe Dennis J
LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model.
Neurobiology of disease 2008;30(1):94-102.
2008: Weihofen Andreas; Ostaszewski Beth; Minami Yasufumi; Selkoe Dennis J
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Human molecular genetics 2008;17(4):602-16.
2008: Cacquevel Matthias; Aeschbach Lorene; Osenkowski Pamela; Li Dongyang; Ye Wenjuan; Wolfe Michael S; Li Huilin; Selkoe Dennis J; Fraering Patrick C
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.
Journal of neurochemistry 2008;104(1):210-20.
2008: Selkoe Dennis J
Biochemistry and Molecular Biology of Amyloid beta-Protein and the Mechanism of Alzheimer's Disease.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2008;89():245-60.
2008: Young-Pearse Tracy L; Chen Allen C; Chang Rui; Marquez Cesar; Selkoe Dennis J
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.
Neural development 2008;3():15.
2007: Selkoe Dennis J
Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease.
Nutrition reviews 2007;65(12 Pt 2):S239-43.
2007: Young-Pearse Tracy L; Bai Jilin; Chang Rui; Zheng Jessica B; LoTurco Joseph J; Selkoe Dennis J
A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(52):14459-69.
2007: Assayag Karen; Yakunin Evgenia; Loeb Virginie; Selkoe Dennis J; Sharon Ronit
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.
The American journal of pathology 2007;171(6):2000-11.
2007: Townsend Matthew; Mehta Tapan; Selkoe Dennis J
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
The Journal of biological chemistry 2007;282(46):33305-12.
2007: Selkoe Dennis J; Wolfe Michael S
Presenilin: running with scissors in the membrane.
Cell 2007;131(2):215-21.
2007: Hemming Matthew L; Patterson Michaela; Reske-Nielsen Casper; Lin Ling; Isacson Ole; Selkoe Dennis J
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.
PLoS medicine 2007;4(8):e262.
2007: Farris Wesley; Schütz Sonja G; Cirrito John R; Shankar Ganesh M; Sun Xiaoyan; George Ana; Leissring Malcolm A; Walsh Dominic M; Qiu Wei Qiao; Holtzman David M; Selkoe Dennis J
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
The American journal of pathology 2007;171(1):241-51.
2007: Walsh Dominic M; Selkoe Dennis J
A beta oligomers - a decade of discovery.
Journal of neurochemistry 2007;101(5):1172-84.
2007: Qiu Wei Qiao; Sun Xiaoyan; Selkoe Dennis J; Mwamburi D Mkaya; Huang Tina; Bhadela Refeeque; Bergethon Peter; Scott Tammy M; Summergrad Paul; Wang Lixia; Rosenberg Irwin; Folstein Marshal
Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.
International journal of geriatric psychiatry 2007;22(6):536-42.
2007: Walsh D M; Minogue A M; Sala Frigerio C; Fadeeva J V; Wasco W; Selkoe D J
The APP family of proteins: similarities and differences.
Biochemical Society transactions 2007;35(Pt 2):416-20.
2007: Hemming Matthew L; Selkoe Dennis J; Farris Wesley
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease.
Neurobiology of disease 2007;26(1):273-81.
2007: Shankar Ganesh M; Bloodgood Brenda L; Townsend Matthew; Walsh Dominic M; Selkoe Dennis J; Sabatini Bernardo L
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(11):2866-75.
2007: Kim Minji; Hersh Louis B; Leissring Malcolm A; Ingelsson Martin; Matsui Toshifumi; Farris Wesley; Lu Alice; Hyman Bradley T; Selkoe Dennis J; Bertram Lars; Tanzi Rudolph E
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Chen Allen C; Selkoe Dennis J
Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554.
Neuron 2007;53(4):479-83.
2007: Haass Christian; Selkoe Dennis J
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Nature reviews. Molecular cell biology 2007;8(2):101-12.
2006: Townsend Matthew; Cleary James P; Mehta Tapan; Hofmeister Jacki; Lesne Sylvain; O'Hare Eugene; Walsh Dominic M; Selkoe Dennis J
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
Annals of neurology 2006;60(6):668-76.
2006: Leissring Malcolm A; Selkoe Dennis J
Structural biology: enzyme target to latch on to.
Nature 2006;443(7113):761-2.
2006: Celone Kim A; Calhoun Vince D; Dickerson Bradford C; Atri Alireza; Chua Elizabeth F; Miller Saul L; DePeau Kristina; Rentz Doreen M; Selkoe Dennis J; Blacker Deborah; Albert Marilyn S; Sperling Reisa A
Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10222-31.
2006: Selkoe Dennis J
The ups and downs of Abeta.
Nature medicine 2006;12(7):758-9; discussion 759.
2006: Lazarov Vlado K; Fraering Patrick C; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J; Li Huilin
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6889-94.
2006: Townsend Matthew; Shankar Ganesh M; Mehta Tapan; Walsh Dominic M; Selkoe Dennis J
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
The Journal of physiology 2006;572(Pt 2):477-92.
2006: Réchards Marloes; Xia Weiming; Oorschot Viola; van Dijk Suzanne; Annaert Willem; Selkoe Dennis J; Klumperman Judith
Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Traffic (Copenhagen, Denmark) 2006;7(3):354-64.
2006: Selkoe Dennis J
Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):163-8.
2005: Fraering Patrick C; Ye Wenjuan; LaVoie Matthew J; Ostaszewski Beth L; Selkoe Dennis J; Wolfe Michael S
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
The Journal of biological chemistry 2005;280(51):41987-96.
2005: Walsh D M; Klyubin I; Shankar G M; Townsend M; Fadeeva J V; Betts V; Podlisny M B; Cleary J P; Ashe K H; Rowan M J; Selkoe D J
The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.
Biochemical Society transactions 2005;33(Pt 5):1087-90.
2005: Whalen Brian M; Selkoe Dennis J; Hartley Dean M
Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration.
Neurobiology of disease 2005;20(2):254-66.
2005: LaVoie Matthew J; Ostaszewski Beth L; Weihofen Andreas; Schlossmacher Michael G; Selkoe Dennis J
Dopamine covalently modifies and functionally inactivates parkin.
Nature medicine 2005;11(11):1214-21.
2005: Hemming Matthew L; Selkoe Dennis J
Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.
The Journal of biological chemistry 2005;280(45):37644-50.
2005: Selkoe Dennis J
By the way, doctor. Is there a brain scan that can specifically diagnose Alzheimer's disease?
Harvard health letter / from Harvard Medical School 2005;30(12):8.
2005: Kimberly W Taylor; Zheng Jessica B; Town Terrence; Flavell Richard A; Selkoe Dennis J
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5533-43.
2005: Farris Wesley; Leissring Malcolm A; Hemming Matthew L; Chang Alice Y; Selkoe Dennis J
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
Biochemistry 2005;44(17):6513-25.
2005: Klyubin Igor; Walsh Dominic M; Lemere Cynthia A; Cullen William K; Shankar Ganesh M; Betts Vicki; Spooner Edward T; Jiang Liying; Anwyl Roger; Selkoe Dennis J; Rowan Michael J
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
Nature medicine 2005;11(5):556-61.
2005: Walsh Dominic M; Townsend Matthew; Podlisny Marcia B; Shankar Ganesh M; Fadeeva Julia V; El Agnaf Omar; Hartley Dean M; Selkoe Dennis J
Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2455-62.
2005: Selkoe Dennis J
Defining molecular targets to prevent Alzheimer disease.
Archives of neurology 2005;62(2):192-5.
2005: Chyung Jay H; Raper Daniel M; Selkoe Dennis J
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
The Journal of biological chemistry 2005;280(6):4383-92.
2005: Cleary James P; Walsh Dominic M; Hofmeister Jacki J; Shankar Ganesh M; Kuskowski Michael A; Selkoe Dennis J; Ashe Karen H
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.
Nature neuroscience 2005;8(1):79-84.
2004: Selkoe Dennis J
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases.
Nature cell biology 2004;6(11):1054-61.
2004: Leissring Malcolm A; Farris Wesley; Wu Xining; Christodoulou Danos C; Haigis Marcia C; Guarente Leonard; Selkoe Dennis J
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.
The Biochemical journal 2004;383(Pt. 3):439-46.
2004: Walsh Dominic M; Selkoe Dennis J
Deciphering the molecular basis of memory failure in Alzheimer's disease.
Neuron 2004;44(1):181-93.
2004: Ye Chianping; Walsh Dominic M; Selkoe Dennis J; Hartley Dean M
Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation.
Neuroscience letters 2004;366(3):320-5.
2004: Fraering Patrick C; Ye Wenjuan; Strub Jean-Marc; Dolios Georgia; LaVoie Matthew J; Ostaszewski Beth L; van Dorsselaer Alain; Wang Rong; Selkoe Dennis J; Wolfe Michael S
Purification and characterization of the human gamma-secretase complex.
Biochemistry 2004;43(30):9774-89.
2004: Lemere Cynthia A; Beierschmitt Amy; Iglesias Melitza; Spooner Edward T; Bloom Jeanne K; Leverone Jodi F; Zheng Jessica B; Seabrook Timothy J; Louard Dora; Li Diana; Selkoe Dennis J; Palmour Roberta M; Ervin Frank R
Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet.
The American journal of pathology 2004;165(1):283-97.
2004: Walsh Dominic M; Selkoe Dennis J
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration.
Protein and peptide letters 2004;11(3):213-28.
2004: Hayashi Hideki; Kimura Nobuyuki; Yamaguchi Haruyasu; Hasegawa Kazuhiro; Yokoseki Tatsuki; Shibata Masao; Yamamoto Naoki; Michikawa Makoto; Yoshikawa Yasuhiro; Terao Keiji; Matsuzaki Katsumi; Lemere Cynthia A; Selkoe Dennis J; Naiki Hironobu; Yanagisawa Katsuhiko
A seed for Alzheimer amyloid in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4894-902.
2004: Klyubin Igor; Walsh Dominic M; Cullen William K; Fadeeva Julia V; Anwyl Roger; Selkoe Dennis J; Rowan Michael J
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.
The European journal of neuroscience 2004;19(10):2839-46.
2004: Selkoe Dennis J;
Alzheimer disease: mechanistic understanding predicts novel therapies.
Annals of internal medicine 2004;140(8):627-38.
2004: Farris Wesley; Mansourian Stefan; Leissring Malcolm A; Eckman Elizabeth A; Bertram Lars; Eckman Christopher B; Tanzi Rudolph E; Selkoe Dennis J
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2004: Wang Qinwen; Walsh Dominic M; Rowan Michael J; Selkoe Dennis J; Anwyl Roger
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(13):3370-8.
2004: Fraering Patrick C; LaVoie Matthew J; Ye Wenjuan; Ostaszewski Beth L; Kimberly W Taylor; Selkoe Dennis J; Wolfe Michael S
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Biochemistry 2004;43(2):323-33.
2003: Leissring Malcolm A; Farris Wesley; Chang Alice Y; Walsh Dominic M; Wu Xining; Sun Xiaoyan; Frosch Matthew P; Selkoe Dennis J
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
Neuron 2003;40(6):1087-93.
2003: Selkoe Dennis J
Folding proteins in fatal ways.
Nature 2003;426(6968):900-4.
2003: Chyung Jay H; Selkoe Dennis J
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface.
The Journal of biological chemistry 2003;278(51):51035-43.
2003: Sharon Ronit; Bar-Joseph Ifat; Mirick Gudrun E; Serhan Charles N; Selkoe Dennis J
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.
The Journal of biological chemistry 2003;278(50):49874-81.
2003: Selkoe Dennis J
Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman.
Neurochemical research 2003;28(11):1705-13.
2003: Baulac Stephanie; LaVoie Matthew J; Kimberly W Taylor; Strahle Jennifer; Wolfe Michael S; Selkoe Dennis J; Xia Weiming
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Neurobiology of disease 2003;14(2):194-204.
2003: Lemere Cynthia A; Spooner Edward T; LaFrancois John; Malester Brian; Mori Chica; Leverone Jodi F; Matsuoka Yasuji; Taylor Jennie W; DeMattos Ronald B; Holtzman David M; Clements John D; Selkoe Dennis J; Duff Karen E
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
2003: Leissring Malcolm A; Lu Alice; Condron Margaret M; Teplow David B; Stein Ross L; Farris Wesley; Selkoe Dennis J
Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.
The Journal of biological chemistry 2003;278(39):37314-20.
2003: LaVoie Matthew J; Fraering Patrick C; Ostaszewski Beth L; Ye Wenjuan; Kimberly W Taylor; Wolfe Michael S; Selkoe Dennis J
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The Journal of biological chemistry 2003;278(39):37213-22.
2003: LaVoie Matthew J; Selkoe Dennis J
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
The Journal of biological chemistry 2003;278(36):34427-37.
2003: Ye Chian P; Selkoe Dennis J; Hartley Dean M
Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures.
Neurobiology of disease 2003;13(3):177-90.
2003: Monsonego Alon; Zota Victor; Karni Arnon; Krieger Jeffery I; Bar-Or Amit; Bitan Gal; Budson Andrew E; Sperling Reisa; Selkoe Dennis J; Weiner Howard L
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.
The Journal of clinical investigation 2003;112(3):415-22.
2003: Réchards Marloes; Xia Weiming; Oorschot Viola M J; Selkoe Dennis J; Klumperman Judith
Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.
Traffic (Copenhagen, Denmark) 2003;4(8):553-65.
2003: Walsh Dominic M; Fadeeva Julia V; LaVoie Matthew J; Paliga Krzysztof; Eggert Simone; Kimberly W Taylor; Wasco Wilma; Selkoe Dennis J
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Biochemistry 2003;42(22):6664-73.
2003: Kimberly W Taylor; LaVoie Matthew J; Ostaszewski Beth L; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6382-7.
2003: Farris Wesley; Mansourian Stefan; Chang Yang; Lindsley Loren; Eckman Elizabeth A; Frosch Matthew P; Eckman Christopher B; Tanzi Rudolph E; Selkoe Dennis J; Guenette Suzanne
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4162-7.
2003: Sharon Ronit; Bar-Joseph Ifat; Frosch Matthew P; Walsh Dominic M; Hamilton James A; Selkoe Dennis J
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.
Neuron 2003;37(4):583-95.
2003: Kimberly W Taylor; Esler William P; Ye Wenjuan; Ostaszewski Beth L; Gao Jun; Diehl Thekla; Selkoe Dennis J; Wolfe Michael S
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2003: Selkoe Dennis J
Toward a remembrance of things past: deciphering Alzheimer disease.
Harvey lectures 2003;99():23-45.
2003: Selkoe Dennis; Kopan Raphael
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
Annual review of neuroscience 2003;26():565-97.
2003: Selkoe Dennis J; Schenk Dale
Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics.
Annual review of pharmacology and toxicology 2003;43():545-84.
2002: Weiner Howard L; Selkoe Dennis J
Inflammation and therapeutic vaccination in CNS diseases.
Nature 2002;420(6917):879-84.
2002: Selkoe Dennis J
Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
The Journal of clinical investigation 2002;110(10):1375-81.
2002: Selkoe Dennis J
Alzheimer's disease is a synaptic failure.
Science (New York, N.Y.) 2002;298(5594):789-91.
2002: Craft David L; Wein Lawrence M; Selkoe Dennis J
A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma.
Bulletin of mathematical biology 2002;64(5):1011-31.
2002: Selkoe Dennis
Alzheimer's disease: Conversation with an expert.
Harvard health letter / from Harvard Medical School 2002;27(11):5.
2002: Kimberly W Taylor; LaVoie Matthew J; Ostaszewski Beth L; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
The Journal of biological chemistry 2002;277(38):35113-7.
2002: Walsh D M; Klyubin I; Fadeeva J V; Rowan M J; Selkoe D J
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition.
Biochemical Society transactions 2002;30(4):552-7.
2002: Hardy John; Selkoe Dennis J
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science (New York, N.Y.) 2002;297(5580):353-6.
2002: Mori Chica; Spooner Edward T; Wisniewsk Krystyna E; Wisniewski Thomas M; Yamaguch Haruyasu; Saido Takaom C; Tolan Dean R; Selkoe Dennis J; Lemere Cynthia A
Intraneuronal Abeta42 accumulation in Down syndrome brain.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(2):88-102.
2002: Wolfe Michael S; Selkoe Dennis J
Biochemistry. Intramembrane proteases--mixing oil and water.
Science (New York, N.Y.) 2002;296(5576):2156-7.
2002: Schlossmacher Michael G; Frosch Matthew P; Gai Wei Ping; Medina Miguel; Sharma Nutan; Forno Lysia; Ochiishi Tomoyo; Shimura Hideki; Sharon Ronit; Hattori Nobutaka; Langston J William; Mizuno Yoshikuni; Hyman Bradley T; Selkoe Dennis J; Kosik Kenneth S
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: Esler William P; Das Chittaranjan; Campbell William A; Kimberly W Taylor; Kornilova Anna Y; Diehl Thekla S; Ye Wenjuan; Ostaszewski Beth L; Xia Weiming; Selkoe Dennis J; Wolfe Michael S
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: Walsh Dominic M; Klyubin Igor; Fadeeva Julia V; Cullen William K; Anwyl Roger; Wolfe Michael S; Rowan Michael J; Selkoe Dennis J
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Nature 2002;416(6880):535-9.
2002: Zhang Jimin; Ye Wenjuan; Wang Rong; Wolfe Michael S; Greenberg Barry D; Selkoe Dennis J
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
The Journal of biological chemistry 2002;277(17):15069-75.
2002: Esler William P; Kimberly W Taylor; Ostaszewski Beth L; Ye Wenjuan; Diehl Thekla S; Selkoe Dennis J; Wolfe Michael S
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2002: Selkoe Dennis J
Introducing transglutaminase into the study of Alzheimer's disease. A personal look back.
Neurochemistry international 2002;40(1):13-6.
2002: Selkoe Dennis J; Podlisny Marcia B
Deciphering the genetic basis of Alzheimer's disease.
Annual review of genomics and human genetics 2002;3():67-99.
2002: Wang H; Wolosker H; Morris John F; Pevsner J; Snyder S H; Selkoe D J
Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system.
Neuroscience 2002;109(1):1-4.
2001: Lemere C A; Maron R; Selkoe D J; Weiner H L
Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease.
DNA and cell biology 2001;20(11):705-11.
2001: Selkoe D J
Clearing the brain's amyloid cobwebs.
Neuron 2001;32(2):177-80.
2001: Kimberly W T; Zheng J B; Guénette S Y; Selkoe D J
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
The Journal of biological chemistry 2001;276(43):40288-92.
2001: Selkoe D J
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11039-41.
2001: Monsonego A; Maron R; Zota V; Selkoe D J; Weiner H L
Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10273-8.
2001: Sharon R; Goldberg M S; Bar-Josef I; Betensky R A; Shen J; Selkoe D J
alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9110-5.
2001: Shimura H; Schlossmacher M G; Hattori N; Frosch M P; Trockenbacher A; Schneider R; Mizuno Y; Kosik K S; Selkoe D J
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
Science (New York, N.Y.) 2001;293(5528):263-9.
2001: Walsh D M; Hartley D M; Condron M M; Selkoe D J; Teplow D B
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.
The Biochemical journal 2001;355(Pt 3):869-77.
2001: Selkoe D J
Alzheimer's disease: genes, proteins, and therapy.
Physiological reviews 2001;81(2):741-66.
2000: Bertram L; Blacker D; Mullin K; Keeney D; Jones J; Basu S; Yhu S; McInnis M G; Go R C; Vekrellis K; Selkoe D J; Saunders A J; Tanzi R E
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Science (New York, N.Y.) 2000;290(5500):2302-3.
2000: Xia W; Ostaszewski B L; Kimberly W T; Rahmati T; Moore C L; Wolfe M S; Selkoe D J
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiology of disease 2000;7(6 Pt B):673-81.
2000: Fezoui Y; Hartley D M; Walsh D M; Selkoe D J; Osterhout J J; Teplow D B
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
Nature structural biology 2000;7(12):1095-9.
2000: Selkoe D J
The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins.
Neurologic clinics 2000;18(4):903-22.
2000: Wang H; Wolosker H; Pevsner J; Snyder S H; Selkoe D J
Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammals.
The Journal of endocrinology 2000;167(2):247-52.
2000: Weiner H L; Lemere C A; Maron R; Spooner E T; Grenfell T J; Mori C; Issazadeh S; Hancock W W; Selkoe D J
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.
Annals of neurology 2000;48(4):567-79.
2000: Chesneau V; Vekrellis K; Rosner M R; Selkoe D J
Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
The Biochemical journal 2000;351 Pt 2():509-16.
2000: Fezoui Y; Hartley D M; Harper J D; Khurana R; Walsh D M; Condron M M; Selkoe D J; Lansbury P T; Fink A L; Teplow D B
An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(3):166-78.
2000: Moore C L; Leatherwood D D; Diehl T S; Selkoe D J; Wolfe M S
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
Journal of medicinal chemistry 2000;43(18):3434-42.
2000: Walsh D M; Tseng B P; Rydel R E; Podlisny M B; Selkoe D J
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain.
Biochemistry 2000;39(35):10831-9.
2000: Selkoe D J
Imaging Alzheimer's amyloid.
Nature biotechnology 2000;18(8):823-4.
2000: Xia W; Ray W J; Ostaszewski B L; Rahmati T; Kimberly W T; Wolfe M S; Zhang J; Goate A M; Selkoe D J
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9299-304.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Kimberly W T; Weinmaster G; Selkoe D J; Hyman B T
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Esler W P; Kimberly W T; Ostaszewski B L; Diehl T S; Moore C L; Tsai J Y; Rahmati T; Xia W; Selkoe D J; Wolfe M S
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
2000: Selkoe D J; Wolfe M S
In search of gamma-secretase: presenilin at the cutting edge.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5690-2.
2000: Selkoe D J
The origins of Alzheimer disease: a is for amyloid.
JAMA : the journal of the American Medical Association 2000;283(12):1615-7.
2000: Vekrellis K; Ye Z; Qiu W Q; Walsh D; Hartley D; Chesneau V; Rosner M R; Selkoe D J
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(5):1657-65.
2000: Selkoe D J
Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.
Current opinion in neurobiology 2000;10(1):50-7.
2000: Stoltzner S E; Grenfell T J; Mori C; Wisniewski K E; Wisniewski T M; Selkoe D J; Lemere C A
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.
The American journal of pathology 2000;156(2):489-99.
2000: Kimberly W T; Xia W; Rahmati T; Wolfe M S; Selkoe D J
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
The Journal of biological chemistry 2000;275(5):3173-8.
2000: Selkoe D J
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.
Annals of the New York Academy of Sciences 2000;924():17-25.
2000: Lemere C A; Maron R; Spooner E T; Grenfell T J; Mori C; Desai R; Hancock W W; Weiner H L; Selkoe D J
Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice.
Annals of the New York Academy of Sciences 2000;920():328-31.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Weinmaster G; Selkoe D J; Hyman B T
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: Moore C L; Diehl T S; Selkoe D J; Wolfe M S
Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.
Annals of the New York Academy of Sciences 2000;920():197-205.
1999: Ray W J; Yao M; Mumm J; Schroeter E H; Saftig P; Wolfe M; Selkoe D J; Kopan R; Goate A M
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
The Journal of biological chemistry 1999;274(51):36801-7.
1999: Hartley D M; Walsh D M; Ye C P; Diehl T; Vasquez S; Vassilev P M; Teplow D B; Selkoe D J
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8876-84.
1999: Walsh D M; Hartley D M; Kusumoto Y; Fezoui Y; Condron M M; Lomakin A; Benedek G B; Selkoe D J; Teplow D B
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
The Journal of biological chemistry 1999;274(36):25945-52.
1999: Wolfe M S; De Los Angeles J; Miller D D; Xia W; Selkoe D J
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Biochemistry 1999;38(35):11223-30.
1999: Lemere C A; Grenfell T J; Selkoe D J
The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome.
The American journal of pathology 1999;155(1):29-37.
1999: Perez R G; Soriano S; Hayes J D; Ostaszewski B; Xia W; Selkoe D J; Chen X; Stokin G B; Koo E H
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
The Journal of biological chemistry 1999;274(27):18851-6.
1999: Poduslo J F; Curran G L; Sanyal B; Selkoe D J
Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier.
Neurobiology of disease 1999;6(3):190-9.
1999: Selkoe D J
Translating cell biology into therapeutic advances in Alzheimer's disease.
Nature 1999;399(6738 Suppl):A23-31.
1999: Watson D J; Selkoe D J; Teplow D B
Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.
The Biochemical journal 1999;340 ( Pt 3)():703-9.
1999: Querfurth H W; Jiang J; Xia W; Selkoe D J
Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.
Gene 1999;232(1):125-41.
1999: Wolfe M S; Xia W; Ostaszewski B L; Diehl T S; Kimberly W T; Selkoe D J
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature 1999;398(6727):513-7.
1999: Wolfe M S; Xia W; Moore C L; Leatherwood D D; Ostaszewski B; Rahmati T; Donkor I O; Selkoe D J
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry 1999;38(15):4720-7.
1999: Westermark P; Araki S; Benson M D; Cohen A S; Frangione B; Masters C L; Saraiva M J; Sipe J D; Husby G; Kyle R A; Selkoe D
Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(1):63-6.
1998: Qiu W Q; Walsh D M; Ye Z; Vekrellis K; Zhang J; Podlisny M B; Rosner M R; Safavi A; Hersh L B; Selkoe D J
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
The Journal of biological chemistry 1998;273(49):32730-8.
1998: Selkoe D J
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Trends in cell biology 1998;8(11):447-53.
1998: Xia W; Zhang J; Ostaszewski B L; Kimberly W T; Seubert P; Koo E H; Shen J; Selkoe D J
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Biochemistry 1998;37(47):16465-71.
1998: Steiner H; Capell A; Pesold B; Citron M; Kloetzel P M; Selkoe D J; Romig H; Mendla K; Haass C
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
The Journal of biological chemistry 1998;273(48):32322-31.
1998: Citron M; Eckman C B; Diehl T S; Corcoran C; Ostaszewski B L; Xia W; Levesque G; St George Hyslop P; Younkin S G; Selkoe D J
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: Xia M Q; Berezovska O; Kim T W; Xia W M; Liao A; Tanzi R E; Selkoe D; Hyman B T
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Zhang J; Kang D E; Xia W; Okochi M; Mori H; Selkoe D J; Koo E H
Subcellular distribution and turnover of presenilins in transfected cells.
The Journal of biological chemistry 1998;273(20):12436-42.
1998: Podlisny M B; Walsh D M; Amarante P; Ostaszewski B L; Stimson E R; Maggio J E; Teplow D B; Selkoe D J
Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.
Biochemistry 1998;37(11):3602-11.
1998: Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe D J; Haass C
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Haass C; Selkoe D J
Alzheimer's disease. A technical KO of amyloid-beta peptide.
Nature 1998;391(6665):339-40.
1998: Wolfe M S; Citron M; Diehl T S; Xia W; Donkor I O; Selkoe D J
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Journal of medicinal chemistry 1998;41(1):6-9.
1997: Watson D J; Lander A D; Selkoe D J
Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.
The Journal of biological chemistry 1997;272(50):31617-24.
1997: Querfurth H W; Jiang J; Geiger J D; Selkoe D J
Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells.
Journal of neurochemistry 1997;69(4):1580-91.
1997: Selkoe D J
Images in neuroscience. Alzheimer's disease: from genes to pathogenesis.
The American journal of psychiatry 1997;154(9):1198.
1997: Xia W; Zhang J; Perez R; Koo E H; Selkoe D J
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8208-13.
1997: Shen J; Bronson R T; Chen D F; Xia W; Selkoe D J; Tonegawa S
Skeletal and CNS defects in Presenilin-1-deficient mice.
Cell 1997;89(4):629-39.
1997: Walter J; Grünberg J; Capell A; Pesold B; Schindzielorz A; Citron M; Mendla K; George-Hyslop P S; Multhaup G; Selkoe D J; Haass C
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: Xia W; Zhang J; Kholodenko D; Citron M; Podlisny M B; Teplow D B; Haass C; Seubert P; Koo E H; Selkoe D J
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
The Journal of biological chemistry 1997;272(12):7977-82.
1997: Qiu W Q; Ye Z; Kholodenko D; Seubert P; Selkoe D J
Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells.
The Journal of biological chemistry 1997;272(10):6641-6.
1997: Yamazaki T; Koo E H; Selkoe D J
Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(3):1004-10.
1997: Selkoe D J
Alzheimer's disease: genotypes, phenotypes, and treatments.
Science (New York, N.Y.) 1997;275(5300):630-1.
1997: Walter J; Capell A; Hung A Y; Langen H; Schnölzer M; Thinakaran G; Sisodia S S; Selkoe D J; Haass C
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: Citron M; Westaway D; Xia W; Carlson G; Diehl T; Levesque G; Johnson-Wood K; Lee M; Seubert P; Davis A; Kholodenko D; Motter R; Sherrington R; Perry B; Yao H; Strome R; Lieberburg I; Rommens J; Kim S; Schenk D; Fraser P; St George Hyslop P; Selkoe D J
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Nature medicine 1997;3(1):67-72.
1997: Poduslo J F; Curran G L; Haggard J J; Biere A L; Selkoe D J
Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier.
Neurobiology of disease 1997;4(1):27-34.
1997: Podlisny M B; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo E H; Seubert P; St George-Hyslop P; Teplow D B; Selkoe D J
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1996: Lalowski M; Golabek A; Lemere C A; Selkoe D J; Wisniewski H M; Beavis R C; Frangione B; Wisniewski T
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
The Journal of biological chemistry 1996;271(52):33623-31.
1996: Biere A L; Ostaszewski B; Stimson E R; Hyman B T; Maggio J E; Selkoe D J
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma.
The Journal of biological chemistry 1996;271(51):32916-22.
1996: Walter J; Capell A; Grünberg J; Pesold B; Schindzielorz A; Prior R; Podlisny M B; Fraser P; Hyslop P S; Selkoe D J; Haass C
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Molecular medicine (Cambridge, Mass.) 1996;2(6):673-91.
1996: Doan A; Thinakaran G; Borchelt D R; Slunt H H; Ratovitsky T; Podlisny M; Selkoe D J; Seeger M; Gandy S E; Price D L; Sisodia S S
Protein topology of presenilin 1.
Neuron 1996;17(5):1023-30.
1996: Citron M; Diehl T S; Gordon G; Biere A L; Seubert P; Selkoe D J
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13170-5.
1996: Lemere C A; Lopera F; Kosik K S; Lendon C L; Ossa J; Saido T C; Yamaguchi H; Ruiz A; Martinez A; Madrigal L; Hincapie L; Arango J C; Anthony D C; Koo E H; Goate A M; Selkoe D J; Arango J C
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Calingasan N Y; Gandy S E; Baker H; Sheu K F; Smith J D; Lamb B T; Gearhart J D; Buxbaum J D; Harper C; Selkoe D J; Price D L; Sisodia S S; Gibson G E
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
The American journal of pathology 1996;149(3):1063-71.
1996: Selkoe D J
Amyloid beta-protein and the genetics of Alzheimer's disease.
The Journal of biological chemistry 1996;271(31):18295-8.
1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Cummings B J; Satou T; Head E; Milgram N W; Cole G M; Savage M J; Podlisny M B; Selkoe D J; Siman R; Greenberg B D; Cotman C W
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.
Neurobiology of aging 1996;17(4):653-9.
1996: Citron M; Diehl T S; Capell A; Haass C; Teplow D B; Selkoe D J
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Neuron 1996;17(1):171-9.
1996: Yamazaki T; Koo E H; Selkoe D J
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.
Journal of cell science 1996;109 ( Pt 5)():999-1008.
1996: Koo E H; Squazzo S L; Selkoe D J; Koo C H
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.
Journal of cell science 1996;109 ( Pt 5)():991-8.
1996: Tamaoka A; Endoh R; Shoji S; Takahashi H; Hirokawa K; Teplow D B; Selkoe D J; Mori H
Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Neurobiology of aging 1996;17(3):405-14.
1996: Qiu W Q; Borth W; Ye Z; Haass C; Teplow D B; Selkoe D J
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.
The Journal of biological chemistry 1996;271(14):8443-51.
1996: Stephenson D T; Lemere C A; Selkoe D J; Clemens J A
Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain.
Neurobiology of disease 1996;3(1):51-63.
1996: Lemere C A; Blusztajn J K; Yamaguchi H; Wisniewski T; Saido T C; Selkoe D J
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1996: Selkoe D J; Yamazaki T; Citron M; Podlisny M B; Koo E H; Teplow D B; Haass C
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.
Annals of the New York Academy of Sciences 1996;777():57-64.
1996: Selkoe D J
Cell biology of the beta-amyloid precursor protein and the genetics of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():587-96.
1995: Haass C; Lemere C A; Capell A; Citron M; Seubert P; Schenk D; Lannfelt L; Selkoe D J
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine 1995;1(12):1291-6.
1995: Munger J S; Haass C; Lemere C A; Shi G P; Wong W S; Teplow D B; Selkoe D J; Chapman H A
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
The Biochemical journal 1995;311 ( Pt 1)():299-305.
1995: Selkoe D J
Alzheimer's amyloid of another flavour.
Nature medicine 1995;1(10):998-9.
1995: Greenberg S M; Qiu W Q; Selkoe D J; Ben-Itzhak A; Kosik K S
Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.
Neuroscience letters 1995;198(1):52-6.
1995: Biere A L; Ostaszewski B; Zhao H; Gillespie S; Younkin S G; Selkoe D J
Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing.
Neurobiology of disease 1995;2(3):177-87.
1995: Selkoe D J
Alzheimer's disease. Missense on the membrane.
Nature 1995;375(6534):734-5.
1995: Yamazaki T; Selkoe D J; Koo E H
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.
The Journal of cell biology 1995;129(2):431-42.
1995: Podlisny M B; Ostaszewski B L; Squazzo S L; Koo E H; Rydell R E; Teplow D B; Selkoe D J
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.
The Journal of biological chemistry 1995;270(16):9564-70.
1995: Lemere C A; Munger J S; Shi G P; Natkin L; Haass C; Chapman H A; Selkoe D J
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
The American journal of pathology 1995;146(4):848-60.
1995: Qiu W Q; Ferreira A; Miller C; Koo E H; Selkoe D J
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(3 Pt 2):2157-67.
1995: Haass C; Capell A; Citron M; Teplow D B; Selkoe D J
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(11):6186-92.
1995: Haas C; Hung A Y; Citron M; Teplow D B; Selkoe D J
beta-Amyloid, protein processing and Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):398-402.
1995: Citron M; Teplow D B; Selkoe D J
Generation of amyloid beta protein from its precursor is sequence specific.
Neuron 1995;14(3):661-70.
1995: Haass C; Koo E H; Capell A; Teplow D B; Selkoe D J
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
The Journal of cell biology 1995;128(4):537-47.
1995: Querfurth H W; Wijsman E M; St George-Hyslop P H; Selkoe D J
Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.
Brain research. Molecular brain research 1995;28(2):319-37.
1994: Citron M; Vigo-Pelfrey C; Teplow D B; Miller C; Schenk D; Johnston J; Winblad B; Venizelos N; Lannfelt L; Selkoe D J
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11993-7.
1994: Selkoe D J
Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease.
Current opinion in neurobiology 1994;4(5):708-16.
1994: Selkoe D J
Alzheimer's disease: a central role for amyloid.
Journal of neuropathology and experimental neurology 1994;53(5):438-47.
1994: Greenberg S M; Koo E H; Selkoe D J; Qiu W Q; Kosik K S
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7104-8.
1994: Haass C; Hung A Y; Selkoe D J; Teplow D B
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
The Journal of biological chemistry 1994;269(26):17741-8.
1994: Querfurth H W; Selkoe D J
Calcium ionophore increases amyloid beta peptide production by cultured cells.
Biochemistry 1994;33(15):4550-61.
1994: Bons N; Mestre N; Ritchie K; Petter A; Podlisny M; Selkoe D
Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus.
Neurobiology of aging 1994;15(2):215-20.
1994: Hung A Y; Selkoe D J
Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein.
The EMBO journal 1994;13(3):534-42.
1994: Haass C; Koo E H; Teplow D B; Selkoe D J
Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1564-8.
1994: Askanas V; Engel W K; Bilak M; Alvarez R B; Selkoe D J
Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.
The American journal of pathology 1994;144(1):177-87.
1994: Selkoe D J
Normal and abnormal biology of the beta-amyloid precursor protein.
Annual review of neuroscience 1994;17():489-517.
1994: Maness L M; Banks W A; Podlisny M B; Selkoe D J; Kastin A J
Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier.
Life sciences 1994;55(21):1643-50.
1994: Selkoe D J
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.
Annual review of cell biology 1994;10():373-403.
1994: Selkoe D J
Alzheimer's disease beyond 1994: the path to therapeutics.
Neurobiology of aging 1994;15 Suppl 2():S131-3.
1993: Haass C; Selkoe D J
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.
Cell 1993;75(6):1039-42.
1993: Citron M; Haass C; Selkoe D J
Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Neurobiology of aging 1993;14(6):571-3.
1993: Hung A Y; Haass C; Nitsch R M; Qiu W Q; Citron M; Wurtman R J; Growdon J H; Selkoe D J
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
The Journal of biological chemistry 1993;268(31):22959-62.
1993: Selkoe D J
Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease.
Trends in neurosciences 1993;16(10):403-9.
1993: Haass C; Hung A Y; Schlossmacher M G; Oltersdorf T; Teplow D B; Selkoe D J
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Annals of the New York Academy of Sciences 1993;695():109-16.
1993: Koo E H; Park L; Selkoe D J
Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4748-52.
1993: Hanley M R; Selkoe D J
Alzheimer's disease. Amyloid precursor on the G(o)
Nature 1993;362(6415):14-5.
1993: Haass C; Hung A Y; Schlossmacher M G; Teplow D B; Selkoe D J
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
The Journal of biological chemistry 1993;268(5):3021-4.
1993: Podlisny M B; Stephenson D T; Frosch M P; Tolan D R; Lieberburg I; Clemens J A; Selkoe D J
Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.
The American journal of pathology 1993;142(1):17-24.
1992: Citron M; Oltersdorf T; Haass C; McConlogue L; Hung A Y; Seubert P; Vigo-Pelfrey C; Lieberburg I; Selkoe D J
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature 1992;360(6405):672-4.
1992: Fraser P E; Nguyen J T; Inouye H; Surewicz W K; Selkoe D J; Podlisny M B; Kirschner D A
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.
Biochemistry 1992;31(44):10716-23.
1992: Hung A Y; Koo E H; Haass C; Selkoe D J
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9439-43.
1992: Selkoe D J
Aging brain, aging mind.
Scientific American 1992;267(3):134-42.
1992: Podlisny M B; Stephenson D T; Frosch M P; Lieberburg I; Clemens J A; Selkoe D J
Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex.
Neurobiology of aging 1992;13(5):561-7.
1992: Mori H; Takio K; Ogawara M; Selkoe D J
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
The Journal of biological chemistry 1992;267(24):17082-6.
1992: Yamaguchi H; Yamazaki T; Lemere C A; Frosch M P; Selkoe D J
Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.
The American journal of pathology 1992;141(1):249-59.
1992: Haass C; Koo E H; Mellon A; Hung A Y; Selkoe D J
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Nature 1992;357(6378):500-3.
1992: Schlossmacher M G; Ostaszewski B L; Hecker L I; Celi A; Haass C; Chin D; Lieberburg I; Furie B C; Furie B; Selkoe D J
Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Neurobiology of aging 1992;13(3):421-34.
1992: Golde T E; Estus S; Younkin L H; Selkoe D J; Younkin S G
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science (New York, N.Y.) 1992;255(5045):728-30.
1992: Tamaoka A; Kalaria R N; Lieberburg I; Selkoe D J
Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1345-9.
1992: Joachim C L; Selkoe D J
The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease.
Alzheimer disease and associated disorders 1992;6(1):7-34.
1991: Haass C; Hung A Y; Selkoe D J
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(12):3783-93.
1991: Selkoe D J
Alzheimer's disease. In the beginning...
Nature 1991;354(6353):432-3.
1991: Selkoe D J
Amyloid protein and Alzheimer's disease.
Scientific American 1991;265(5):68-71, 74-6, 78.
1991: Podlisny M B; Tolan D R; Selkoe D J
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
The American journal of pathology 1991;138(6):1423-35.
1991: Selkoe D J
The molecular pathology of Alzheimer's disease.
Neuron 1991;6(4):487-98.
1991: Joachim C; Games D; Morris J; Ward P; Frenkel D; Selkoe D
Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.
The American journal of pathology 1991;138(2):373-84.
1990: Bodmer S; Podlisny M B; Selkoe D J; Heid I; Fontana A
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Biochemical and biophysical research communications 1990;171(2):890-7.
1990: Selkoe D J
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
Science (New York, N.Y.) 1990;248(4959):1058-60.
1990: Mori H; Selkoe D J
[Biochemistry of Alzheimer's disease]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(7 Suppl):1353-61.
1990: Podlisny M B; Mammen A L; Schlossmacher M G; Palmert M R; Younkin S G; Selkoe D J
Detection of soluble forms of the beta-amyloid precursor protein in human plasma.
Biochemical and biophysical research communications 1990;167(3):1094-101.
1990: Selkoe D J; Podlisny M B; Gronbeck A; Mammen A; Kosik K S
Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease.
Advances in neurology 1990;51():171-9.
1989: Palmert M R; Siedlak S L; Podlisny M B; Greenberg B; Shelton E R; Chan H W; Usiak M; Selkoe D J; Perry G; Younkin S G
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Biochemical and biophysical research communications 1989;165(1):182-8.
1989: Itagaki S; McGeer P L; Akiyama H; Zhu S; Selkoe D
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.
Journal of neuroimmunology 1989;24(3):173-82.
1989: Joachim C L; Mori H; Selkoe D J
Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease.
Nature 1989;341(6239):226-30.
1989: Selkoe D J
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease.
Neurobiology of aging 1989;10(5):387-95.
1989: Joachim C L; Morris J H; Selkoe D J
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.
The American journal of pathology 1989;135(2):309-19.
1989: Selkoe D J
Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease.
Cell 1989;58(4):611-2.
1989: Palmert M R; Podlisny M B; Witker D S; Oltersdorf T; Younkin L H; Selkoe D J; Younkin S G
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6338-42.
1989: Joachim C L; Selkoe D J
Amyloid protein in Alzheimer's disease.
Journal of gerontology 1989;44(4):B77-82.
1989: Selkoe D J
Aging, amyloid, and Alzheimer's disease.
The New England journal of medicine 1989;320(22):1484-7.
1989: Whitson J S; Selkoe D J; Cotman C W
Amyloid beta protein enhances the survival of hippocampal neurons in vitro.
Science (New York, N.Y.) 1989;243(4897):1488-90.
1989: Abraham C R; Selkoe D J; Potter H; Price D L; Cork L C
Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits.
Neuroscience 1989;32(3):715-20.
1989: Selkoe D J
Biochemistry of altered brain proteins in Alzheimer's disease.
Annual review of neuroscience 1989;12():463-90.
1989: Forno L S; Eng L F; Selkoe D J
Pick bodies in the locus ceruleus.
Acta neuropathologica 1989;79(1):10-7.
1989: Selkoe D J
The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease.
Annals of medicine 1989;21(2):73-6.
1988: Joachim C L; Duffy L K; Morris J H; Selkoe D J
Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.
Brain research 1988;474(1):100-11.
1988: Cork L C; Powers R E; Selkoe D J; Davies P; Geyer J J; Price D L
Neurofibrillary tangles and senile plaques in aged bears.
Journal of neuropathology and experimental neurology 1988;47(6):629-41.
1988: Palmert M R; Podlisny M B; Witker D S; Oltersdorf T; Younkin L H; Selkoe D J; Younkin S G
Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques.
Biochemical and biophysical research communications 1988;156(1):432-7.
1988: Selkoe D J; Podlisny M B; Joachim C L; Vickers E A; Lee G; Fritz L C; Oltersdorf T
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7341-5.
1988: Joachim C L; Morris J H; Selkoe D J
Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases.
Annals of neurology 1988;24(1):50-6.
1988: Nukina N; Kosik K S; Selkoe D J
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain.
Neuroscience letters 1988;87(3):240-6.
1988: Abraham C R; Selkoe D J; Potter H
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
Cell 1988;52(4):487-501.
1988: Munoz D G; Greene C; Perl D P; Selkoe D J
Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.
Journal of neuropathology and experimental neurology 1988;47(1):9-18.
1987: Joachim C L; Morris J H; Selkoe D J; Kosik K S
Tau epitopes are incorporated into a range of lesions in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1987;46(6):611-22.
1987: Kirschner D A; Inouye H; Duffy L K; Sinclair A; Lind M; Selkoe D J
Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6953-7.
1987: Joachim C L; Morris J H; Kosik K S; Selkoe D J
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.
Annals of neurology 1987;22(4):514-20.
1987: Podlisny M B; Lee G; Selkoe D J
Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):669-71.
1987: Eidelberg D; Sotrel A; Joachim C; Selkoe D; Forman A; Pendlebury W W; Perl D P
Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity.
Brain : a journal of neurology 1987;110 ( Pt 4)():993-1013.
1987: Nukina N; Kosik K S; Selkoe D J
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3415-9.
1987: Selkoe D J; Bell D S; Podlisny M B; Price D L; Cork L C
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Science (New York, N.Y.) 1987;235(4791):873-7.
1986: Selkoe D J
Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?
Neurobiology of aging 1986;7(6):425-32.
1986: Neve R L; Selkoe D J; Kurnit D M; Kosik K S
A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle.
Brain research 1986;387(2):193-6.
1986: Rasool C G; Svendsen C N; Selkoe D J
Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease.
Annals of neurology 1986;20(4):482-8.
1986: Selkoe D J; Abraham C R; Podlisny M B; Duffy L K
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.
Journal of neurochemistry 1986;46(6):1820-34.
1986: Kosik K S; Joachim C L; Selkoe D J
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):4044-8.
1986: Perry G; Selkoe D J; Block B R; Stewart D; Autilio-Gambetti L; Gambetti P
Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments.
Journal of neuropathology and experimental neurology 1986;45(2):161-8.
1986: Kirschner D A; Abraham C; Selkoe D J
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):503-7.
1986: Selkoe D J; Abraham C R
Isolation of paired helical filaments and amyloid fibers from human brain.
Methods in enzymology 1986;134():388-404.
1986: Kosik K S; Bakalis S; Galibert L; Selkoe D J; Duffy L K
Age-related modifications of MAP-2.
Annals of the New York Academy of Sciences 1986;466():420-2.
1986: Kosik K S; Bakalis S F; Selkoe D J; Pierce M W; Duffy L K
High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions.
Journal of neuroscience research 1986;15(4):543-51.
1985: Rasool C G; Selkoe D J
Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease.
The New England journal of medicine 1985;312(11):700-5.
1985: Selkoe D J; Abraham C; Rasool C G; McCluskey A; Kosik K S; Duffy L K
Paired helical filaments in human neurons: relationship to neurofilaments.
Annals of the New York Academy of Sciences 1985;455():583-96.
1985: Kosik K S; McCluskey A H; Walsh F X; Selkoe D J
Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport.
Neurochemical pathology 1985;3(2):99-108.
1984: Kosik K S; Duffy L K; Dowling M M; Abraham C; McCluskey A; Selkoe D J
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7941-5.
1984: Rasool C G; Selkoe D J
Alzheimer's disease: exposure of neurofilament immunoreactivity in SDS-insoluble paired helical filaments.
Brain research 1984;322(1):194-8.
1984: Kosik K S; Selkoe D J; Sapirstein V
Possible modifications of vimentin following acquisition of triton insolubility.
Biochemistry international 1984;9(4):483-90.
1984: Rasool C G; Abraham C; Anderton B H; Haugh M; Kahn J; Selkoe D J
Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies.
Brain research 1984;310(2):249-60.
1984: Bignami A; Selkoe D J; Dahl D
Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex.
Acta neuropathologica 1984;64(3):243-50.
1983: Ihara Y; Abraham C; Selkoe D J
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.
Nature 1983;304(5928):727-30.
1983: Kosik K S; Bradley W G; Good P F; Rasool C G; Selkoe D J
Cholinergic function in lumbar aluminum myelopathy.
Journal of neuropathology and experimental neurology 1983;42(4):365-75.
1982: Kosik K S; Gilbert J M; Selkoe D J; Strocchi P
Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis.
Journal of neurochemistry 1982;39(6):1529-38.
1982: Selkoe D J; Abraham C; Ihara Y
Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(19):6070-4.
1982: Selkoe D J; Salazar F J; Abraham C; Kosik K S
Huntington's disease: changes in striatal proteins reflect astrocytic gliosis.
Brain research 1982;245(1):117-25.
1982: Selkoe D J; Ihara Y; Salazar F J
Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.
Science (New York, N.Y.) 1982;215(4537):1243-5.
1982: Dahl D; Selkoe D J; Pero R T; Bignami A
Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(1):113-9.
1981: Breuer A C; Cuervo H; Selkoe D J
Hyperpathia and sensory level due to parietal lobe arteriovenous malformation.
Archives of neurology 1981;38(11):722-4.
1981: Selkoe D J; Brown B A; Salazar F J; Marotta C A
Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.
Annals of neurology 1981;10(5):429-36.
1981: Borges L F; Hallett M; Selkoe D J; Welch K
The anterior tarsal tunnel syndrome. Report of two cases.
Journal of neurosurgery 1981;54(1):89-92.
1981: Rothenberg S J; Selkoe D
Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements.
Psychopharmacology 1981;74(3):237-40.
1981: Rothenberg S J; Selkoe D
Specific oculomotor deficit after diazepam. I. Saccadic eye movements.
Psychopharmacology 1981;74(3):232-6.
1980: Selkoe D J
Altered protein composition of isolated human cortical neurons in Alzheimer disease.
Annals of neurology 1980;8(5):468-78.
1980: Rothenberg S; Schottenfeld S; Selkoe D; Gross K
Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements.
Psychopharmacology 1980;67(3):229-34.
1980: Rothenberg S; Schottenfeld S; Gross K; Selkoe D
Specific oculomotor deficit after acute methadone. I. Saccadic eye movements.
Psychopharmacology 1980;67(3):221-7.
1979: Selkoe D J
Nucleotide dependence of successive cycles of tubulin assembly.
Brain research 1979;172(2):382-6.
1979: Selkoe D J; Liem R K; Yen S H; Shelanski M L
Biochemical and immunological characterization of neurofilaments in experimental neurofibrillary degeneration induced by aluminum.
Brain research 1979;163(2):235-52.
1979: Selkoe D J; Myers R E
Neurologic and cardiovascular effects of hypotension in the monkey.
Stroke; a journal of cerebral circulation 1979;10(2):147-57.
1979: Liem R K; Selkoe D J; Yen S H; Salomon G; Shelanski M L
New insights on the composition of neurofilaments.
Research publications - Association for Research in Nervous and Mental Disease 1979;57():145-52.
1979: Selkoe D J
Disease-related protein changes in purified neurons from Alzheimer's and Huntington's diseases.
Transactions of the American Neurological Association 1979;104():70-4.
1978: Selkoe D J; Luckenbill-Edds L; Shelanski M L
Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives.
Journal of neuropathology and experimental neurology 1978;37(6):768-89.
1975: Levitt L P; Selkoe D J; Frankenfield B; Schoene W
Pure motor hemiplegia secondary to brain-stem tumour.
Journal of neurology, neurosurgery, and psychiatry 1975;38(12):1240-3.
1970: Shein H M; Britva A; Hess H H; Selkoe D J
Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA.
Brain research 1970;19(3):497-501.
1969: Selkoe D J
Familial hyperprolinemia and mental retardation. A second metabolic type.
Neurology 1969;19(5):494-502.

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