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William Sellers

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Tumor Cell Line

Chemicals & Drugs

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Disorders

Living Beings

Mice

Physiology

Concepts & Ideas

Devices

Oligonucleotide Array Sequence Analysis

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Publications

TOP 3
Dutt A; Salvesen H B; Greulich H; Sellers W R; Beroukhim R; Meyerson M
Somatic mutations are present in all members of the AKT family in endometrial carcinoma.
Rabinovsky Rosalia; Pochanard Panisa; McNear Chontelle; Brachmann Saskia M; Duke-Cohan Jonathan S; Garraway Levi A; Sellers William R
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Vasudevan Krishna M; Barbie David A; Davies Michael A; Rabinovsky Rosalia; McNear Chontelle J; Kim Jessica J; Hennessy Bryan T; Tseng Hsiuyi; Pochanard Panisa; Kim So Young; Dunn Ian F; Schinzel Anna C; Sandy Peter; Hoersch Sebastian; Sheng Qing; Gupta Piyush B; Boehm Jesse S; Reiling Jan H; Silver Serena; Lu Yiling; Stemke-Hale Katherine; Dutta Bhaskar; Joy Corwin; Sahin Aysegul A; Gonzalez-Angulo Ana Maria; Lluch Ana; Rameh Lucia E; Jacks Tyler; Root David E; Lander Eric S; Mills Gordon B; Hahn William C; Sellers William R; Garraway Levi A
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

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All Publications

2009: Dutt A; Salvesen H B; Greulich H; Sellers W R; Beroukhim R; Meyerson M
Somatic mutations are present in all members of the AKT family in endometrial carcinoma.
British journal of cancer 2009;101(7):1218-9; author reply 1220-1.
2009: Rabinovsky Rosalia; Pochanard Panisa; McNear Chontelle; Brachmann Saskia M; Duke-Cohan Jonathan S; Garraway Levi A; Sellers William R
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Molecular and cellular biology 2009;29(19):5377-88.
2009: Vasudevan Krishna M; Barbie David A; Davies Michael A; Rabinovsky Rosalia; McNear Chontelle J; Kim Jessica J; Hennessy Bryan T; Tseng Hsiuyi; Pochanard Panisa; Kim So Young; Dunn Ian F; Schinzel Anna C; Sandy Peter; Hoersch Sebastian; Sheng Qing; Gupta Piyush B; Boehm Jesse S; Reiling Jan H; Silver Serena; Lu Yiling; Stemke-Hale Katherine; Dutta Bhaskar; Joy Corwin; Sahin Aysegul A; Gonzalez-Angulo Ana Maria; Lluch Ana; Rameh Lucia E; Jacks Tyler; Root David E; Lander Eric S; Mills Gordon B; Hahn William C; Sellers William R; Garraway Levi A
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Cancer cell 2009;16(1):21-32.
2009: Beroukhim Rameen; Brunet Jean-Philippe; Di Napoli Arianna; Mertz Kirsten D; Seeley Apryle; Pires Maira M; Linhart David; Worrell Robert A; Moch Holger; Rubin Mark A; Sellers William R; Meyerson Matthew; Linehan W Marston; Kaelin William G; Signoretti Sabina
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer research 2009;69(11):4674-81.
2009: Wee Susan; Jagani Zainab; Xiang Kay Xiaoqin; Loo Alice; Dorsch Marion; Yao Yung-Mae; Sellers William R; Lengauer Christoph; Stegmeier Frank
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers.
Cancer research 2009;69(10):4286-93.
2009: Stuart Darrin; Sellers William R
Linking somatic genetic alterations in cancer to therapeutics.
Current opinion in cell biology 2009;21(2):304-10.
2009: Salvesen H B; Carter S L; Mannelqvist M; Dutt A; Getz G; Stefansson I M; Raeder M B; Sos M L; Engelsen I B; Trovik J; Wik E; Greulich H; Bø T H; Jonassen I; Thomas R K; Zander T; Garraway L A; Oyan A M; Sellers W R; Kalland K H; Meyerson M; Akslen L A; Beroukhim R
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4834-9.
2009: Etemadmoghadam Dariush; deFazio Anna; Beroukhim Rameen; Mermel Craig; George Joshy; Getz Gad; Tothill Richard; Okamoto Aikou; Raeder Maria B; Harnett Paul; Lade Stephen; Akslen Lars A; Tinker Anna V; Locandro Bianca; Alsop Kathryn; Chiew Yoke-Eng; Traficante Nadia; Fereday Sian; Johnson Daryl; Fox Stephen; Sellers William; Urashima Mitsuyoshi; Salvesen Helga B; Meyerson Matthew; Bowtell David;
Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(4):1417-27.
2009: Wiederschain Dmitri; Wee Susan; Chen Lin; Loo Alice; Yang Guizhi; Huang Alan; Chen Yan; Caponigro Giordano; Yao Yung-Mae; Lengauer Christoph; Sellers William R; Benson John D
Single-vector inducible lentiviral RNAi system for oncology target validation.
Cell cycle (Georgetown, Tex.) 2009;8(3):498-504.
2008: Garcia-Echeverria C; Sellers W R
Drug discovery approaches targeting the PI3K/Akt pathway in cancer.
Oncogene 2008;27(41):5511-26.
2008: Chiang Derek Y; Villanueva Augusto; Hoshida Yujin; Peix Judit; Newell Philippa; Minguez Beatriz; LeBlanc Amanda C; Donovan Diana J; Thung Swan N; Solé Manel; Tovar Victoria; Alsinet Clara; Ramos Alex H; Barretina Jordi; Roayaie Sasan; Schwartz Myron; Waxman Samuel; Bruix Jordi; Mazzaferro Vincenzo; Ligon Azra H; Najfeld Vesna; Friedman Scott L; Sellers William R; Meyerson Matthew; Llovet Josep M
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.
Cancer research 2008;68(16):6779-88.
2008: Majumder Pradip K; Grisanzio Chiara; O'Connell Fionnuala; Barry Marc; Brito Joseph M; Xu Qing; Guney Isil; Berger Raanan; Herman Paula; Bikoff Rachel; Fedele Giuseppe; Baek Won-Ki; Wang Shunyou; Ellwood-Yen Katharine; Wu Hong; Sawyers Charles L; Signoretti Sabina; Hahn William C; Loda Massimo; Sellers William R
A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.
Cancer cell 2008;14(2):146-55.
2008: Maira Sauveur-Michel; Stauffer Frédéric; Brueggen Josef; Furet Pascal; Schnell Christian; Fritsch Christine; Brachmann Saskia; Chène Patrick; De Pover Alain; Schoemaker Kevin; Fabbro Doriano; Gabriel Daniela; Simonen Marjo; Murphy Leon; Finan Peter; Sellers William; García-Echeverría Carlos
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity.
Molecular cancer therapeutics 2008;7(7):1851-63.
2008: Dutt Amit; Salvesen Helga B; Chen Tzu-Hsiu; Ramos Alex H; Onofrio Robert C; Hatton Charlie; Nicoletti Richard; Winckler Wendy; Grewal Rupinder; Hanna Megan; Wyhs Nicolas; Ziaugra Liuda; Richter Daniel J; Trovik Jone; Engelsen Ingeborg B; Stefansson Ingunn M; Fennell Tim; Cibulskis Kristian; Zody Michael C; Akslen Lars A; Gabriel Stacey; Wong Kwok-Kin; Sellers William R; Meyerson Matthew; Greulich Heidi
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8713-7.
2008: Chang Chun-Ju; Mulholland David J; Valamehr Bahram; Mosessian Sherly; Sellers William R; Wu Hong
PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.
Molecular and cellular biology 2008;28(10):3281-9.
2008: Demichelis Francesca; Greulich Heidi; Macoska Jill A; Beroukhim Rameen; Sellers William R; Garraway Levi; Rubin Mark A
SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines.
Nucleic acids research 2008;36(7):2446-56.
2008: Lin William M; Baker Alissa C; Beroukhim Rameen; Winckler Wendy; Feng Whei; Marmion Jennifer M; Laine Elisabeth; Greulich Heidi; Tseng Hsiuyi; Gates Casey; Hodi F Stephen; Dranoff Glenn; Sellers William R; Thomas Roman K; Meyerson Matthew; Golub Todd R; Dummer Reinhard; Herlyn Meenhard; Getz Gad; Garraway Levi A
Modeling genomic diversity and tumor dependency in malignant melanoma.
Cancer research 2008;68(3):664-73.
2008: Engelsen Ingeborg B; Stefansson Ingunn M; Beroukhim Rameen; Sellers William R; Meyerson Matthew; Akslen Lars A; Salvesen Helga B
HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas.
International journal of oncology 2008;32(2):307-16.
2008: Sawai Ayana; Chandarlapaty Sarat; Greulich Heidi; Gonen Mithat; Ye Qing; Arteaga Carlos L; Sellers William; Rosen Neal; Solit David B
Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.
Cancer research 2008;68(2):589-96.
2008: Li Cheng; Beroukhim Rameen; Weir Barbara A; Winckler Wendy; Garraway Levi A; Sellers William R; Meyerson Matthew
Major copy proportion analysis of tumor samples using SNP arrays.
BMC bioinformatics 2008;9():204.
2007: Gaither Alex; Porter Dale; Yao Yao; Borawski Jason; Yang Guang; Donovan Jerry; Sage David; Slisz Joanna; Tran Mary; Straub Christopher; Ramsey Tim; Iourgenko Vadim; Huang Alan; Chen Yan; Schlegel Robert; Labow Mark; Fawell Stephen; Sellers William R; Zawel Leigh
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.
Cancer research 2007;67(24):11493-8.
2007: Beroukhim Rameen; Getz Gad; Nghiemphu Leia; Barretina Jordi; Hsueh Teli; Linhart David; Vivanco Igor; Lee Jeffrey C; Huang Julie H; Alexander Sethu; Du Jinyan; Kau Tweeny; Thomas Roman K; Shah Kinjal; Soto Horacio; Perner Sven; Prensner John; Debiasi Ralph M; Demichelis Francesca; Hatton Charlie; Rubin Mark A; Garraway Levi A; Nelson Stan F; Liau Linda; Mischel Paul S; Cloughesy Tim F; Meyerson Matthew; Golub Todd A; Lander Eric S; Mellinghoff Ingo K; Sellers William R
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):20007-12.
2007: Xu Qing; Majumder Pradip K; Ross Kenneth; Shim Yeonju; Golub Todd R; Loda Massimo; Sellers William R
Identification of prostate cancer modifier pathways using parental strain expression mapping.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17771-6.
2007: Hill Anthony D; Chang Bernard S; Hill R Sean; Garraway Levi A; Bodell Adria; Sellers William R; Walsh Christopher A
A 2-Mb critical region implicated in the microcephaly associated with terminal 1q deletion syndrome.
American journal of medical genetics. Part A 2007;143A(15):1692-8.
2007: Thomas Roman K; Baker Alissa C; Debiasi Ralph M; Winckler Wendy; Laframboise Thomas; Lin William M; Wang Meng; Feng Whei; Zander Thomas; MacConaill Laura; Lee Jeffrey C; Nicoletti Rick; Hatton Charlie; Goyette Mary; Girard Luc; Majmudar Kuntal; Ziaugra Liuda; Wong Kwok-Kin; Gabriel Stacey; Beroukhim Rameen; Peyton Michael; Barretina Jordi; Dutt Amit; Emery Caroline; Greulich Heidi; Shah Kinjal; Sasaki Hidefumi; Gazdar Adi; Minna John; Armstrong Scott A; Mellinghoff Ingo K; Hodi F Stephen; Dranoff Glenn; Mischel Paul S; Cloughesy Tim F; Nelson Stan F; Liau Linda M; Mertz Kirsten; Rubin Mark A; Moch Holger; Loda Massimo; Catalona William; Fletcher Jonathan; Signoretti Sabina; Kaye Frederic; Anderson Kenneth C; Demetri George D; Dummer Reinhard; Wagner Stephan; Herlyn Meenhard; Sellers William R; Meyerson Matthew; Garraway Levi A
High-throughput oncogene mutation profiling in human cancer.
Nature genetics 2007;39(3):347-51.
2006: Lee Jeffrey C; Vivanco Igor; Beroukhim Rameen; Huang Julie H Y; Feng Whei L; DeBiasi Ralph M; Yoshimoto Koji; King Jennifer C; Nghiemphu Phioanh; Yuza Yuki; Xu Qing; Greulich Heidi; Thomas Roman K; Paez J Guillermo; Peck Timothy C; Linhart David J; Glatt Karen A; Getz Gad; Onofrio Robert; Ziaugra Liuda; Levine Ross L; Gabriel Stacey; Kawaguchi Tomohiro; O'Neill Keith; Khan Haumith; Liau Linda M; Nelson Stanley F; Rao P Nagesh; Mischel Paul; Pieper Russell O; Cloughesy Tim; Leahy Daniel J; Sellers William R; Sawyers Charles L; Meyerson Matthew; Mellinghoff Ingo K
Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.
PLoS medicine 2006;3(12):e485.
2006: Perner Sven; Demichelis Francesca; Beroukhim Rameen; Schmidt Folke H; Mosquera Juan-Miguel; Setlur Sunita; Tchinda Joelle; Tomlins Scott A; Hofer Matthias D; Pienta Kenneth G; Kuefer Rainer; Vessella Robert; Sun Xiao-Wei; Meyerson Matthew; Lee Charles; Sellers William R; Chinnaiyan Arul M; Rubin Mark A
TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.
Cancer research 2006;66(17):8337-41.
2006: Li Andrew G; Piluso Landon G; Cai Xin; Wei Gang; Sellers William R; Liu Xuan
Mechanistic insights into maintenance of high p53 acetylation by PTEN.
Molecular cell 2006;23(4):575-87.
2006: Garraway Levi A; Sellers William R
Lineage dependency and lineage-survival oncogenes in human cancer.
Nature reviews. Cancer 2006;6(8):593-602.
2006: Thomas Roman K; Nickerson Elizabeth; Simons Jan F; Jänne Pasi A; Tengs Torstein; Yuza Yuki; Garraway Levi A; LaFramboise Thomas; Lee Jeffrey C; Shah Kinjal; O'Neill Keith; Sasaki Hidefumi; Lindeman Neal; Wong Kwok-Kin; Borras Ana M; Gutmann Edward J; Dragnev Konstantin H; DeBiasi Ralph; Chen Tzu-Hsiu; Glatt Karen A; Greulich Heidi; Desany Brian; Lubeski Christine K; Brockman William; Alvarez Pablo; Hutchison Stephen K; Leamon J H; Ronan Michael T; Turenchalk Gregory S; Egholm Michael; Sellers William R; Rothberg Jonathan M; Meyerson Matthew
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing.
Nature medicine 2006;12(7):852-5.
2006: Oh William K; Hayes Julia; Evan Carolyn; Manola Judith; George Daniel J; Waldron Helen; Donovan Meaghan; Varner John; Orechia John; Katcher Beth; Lu Diana; Nevins Arthur; Wright Renée L; Tormey Lauren; Talcott James; Rubin Mark A; Loda Massimo; Sellers William R; Richie Jerome P; Kantoff Philip W; Weeks Jane
Development of an integrated prostate cancer research information system.
Clinical genitourinary cancer 2006;5(1):61-6.
2006: Benson John D; Chen Ying-Nan P; Cornell-Kennon Susan A; Dorsch Marion; Kim Sunkyu; Leszczyniecka Magdalena; Sellers William R; Lengauer Christoph
Validating cancer drug targets.
Nature 2006;441(7092):451-6.
2006: Beroukhim Rameen; Lin Ming; Park Yuhyun; Hao Ke; Zhao Xiaojun; Garraway Levi A; Fox Edward A; Hochberg Ephraim P; Mellinghoff Ingo K; Hofer Matthias D; Descazeaud Aurelien; Rubin Mark A; Meyerson Matthew; Wong Wing Hung; Sellers William R; Li Cheng
Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.
PLoS computational biology 2006;2(5):e41.
2006: Alvarez James V; Greulich Heidi; Sellers William R; Meyerson Matthew; Frank David A
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.
Cancer research 2006;66(6):3162-8.
2006: Vazquez Francisca; Matsuoka Satomi; Sellers William R; Yanagida Toshio; Ueda Masahiro; Devreotes Peter N
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3633-8.
2006: Garraway Levi A; Sellers William R
From integrated genomics to tumor lineage dependency.
Cancer research 2006;66(5):2506-8.
2006: Solit David B; Garraway Levi A; Pratilas Christine A; Sawai Ayana; Getz Gad; Basso Andrea; Ye Qing; Lobo Jose M; She Yuhong; Osman Iman; Golub Todd R; Sebolt-Leopold Judith; Sellers William R; Rosen Neal
BRAF mutation predicts sensitivity to MEK inhibition.
Nature 2006;439(7074):358-62.
2005: Mihich Enrico; Sellers William R
Seventeenth Annual Pezcoller Symposium: molecular understanding of solid tumors.
Cancer research 2005;65(24):11251-4.
2005: Koochekpour Shahriar; Zhuang Yu-Jun; Beroukhim Rameen; Hsieh Chia-Ling; Hofer Matthias D; Zhau Haiyen E; Hiraiwa Masao; Pattan Daniel Y; Ware Joy L; Luftig Ronald B; Sandhoff Konrad; Sawyers Charles L; Pienta Kenneth J; Rubin Mark A; Vessella Robert L; Sellers William R; Sartor Oliver
Amplification and overexpression of prosaposin in prostate cancer.
Genes, chromosomes & cancer 2005;44(4):351-64.
2005: LaFramboise Thomas; Weir Barbara A; Zhao Xiaojun; Beroukhim Rameen; Li Cheng; Harrington David; Sellers William R; Meyerson Matthew
Allele-specific amplification in cancer revealed by SNP array analysis.
PLoS computational biology 2005;1(6):e65.
2005: Majumder Pradip K; Sellers William R
Akt-regulated pathways in prostate cancer.
Oncogene 2005;24(50):7465-74.
2005: Mellinghoff Ingo K; Wang Maria Y; Vivanco Igor; Haas-Kogan Daphne A; Zhu Shaojun; Dia Ederlyn Q; Lu Kan V; Yoshimoto Koji; Huang Julie H Y; Chute Dennis J; Riggs Bridget L; Horvath Steve; Liau Linda M; Cavenee Webster K; Rao P Nagesh; Beroukhim Rameen; Peck Timothy C; Lee Jeffrey C; Sellers William R; Stokoe David; Prados Michael; Cloughesy Timothy F; Sawyers Charles L; Mischel Paul S
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
The New England journal of medicine 2005;353(19):2012-24.
2005: Greulich Heidi; Chen Tzu-Hsiu; Feng Whei; Jänne Pasi A; Alvarez James V; Zappaterra Mauro; Bulmer Sara E; Frank David A; Hahn William C; Sellers William R; Meyerson Matthew
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
PLoS medicine 2005;2(11):e313.
2005: Jiang Jingrui; Greulich Heidi; Jänne Pasi A; Sellers William R; Meyerson Matthew; Griffin James D
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
Cancer research 2005;65(19):8968-74.
2005: Signoretti Sabina; Pires Maira M; Lindauer Meghan; Horner James W; Grisanzio Chiara; Dhar Sonya; Majumder Pradip; McKeon Frank; Kantoff Philip W; Sellers William R; Loda Massimo
p63 regulates commitment to the prostate cell lineage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11355-60.
2005: Garraway Levi A; Widlund Hans R; Rubin Mark A; Getz Gad; Berger Aaron J; Ramaswamy Sridhar; Beroukhim Rameen; Milner Danny A; Granter Scott R; Du Jinyan; Lee Charles; Wagner Stephan N; Li Cheng; Golub Todd R; Rimm David L; Meyerson Matthew L; Fisher David E; Sellers William R
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
Nature 2005;436(7047):117-22.
2005: Zhao Xiaojun; Weir Barbara A; LaFramboise Thomas; Lin Ming; Beroukhim Rameen; Garraway Levi; Beheshti Javad; Lee Jeffrey C; Naoki Katsuhiko; Richards William G; Sugarbaker David; Chen Fei; Rubin Mark A; Jänne Pasi A; Girard Luc; Minna John; Christiani David; Li Cheng; Sellers William R; Meyerson Matthew
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis.
Cancer research 2005;65(13):5561-70.
2005: Levine Ross L; Wadleigh Martha; Cools Jan; Ebert Benjamin L; Wernig Gerlinde; Huntly Brian J P; Boggon Titus J; Wlodarska Iwona; Clark Jennifer J; Moore Sandra; Adelsperger Jennifer; Koo Sumin; Lee Jeffrey C; Gabriel Stacey; Mercher Thomas; D'Andrea Alan; Fröhling Stefan; Döhner Konstanze; Marynen Peter; Vandenberghe Peter; Mesa Ruben A; Tefferi Ayalew; Griffin James D; Eck Michael J; Sellers William R; Meyerson Matthew; Golub Todd R; Lee Stephanie J; Gilliland D Gary
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Cancer cell 2005;7(4):387-97.
2005: Krützfeldt Maja; Ellis Mark; Weekes Daniel B; Bull Jonathan J; Eilers Martin; Vivanco Maria D M; Sellers William R; Mittnacht Sibylle
Selective ablation of retinoblastoma protein function by the RET finger protein.
Molecular cell 2005;18(2):213-24.
2005: Sellers William R; Meyerson Matthew
EGFR gene mutations: a call for global x global views of cancer.
Journal of the National Cancer Institute 2005;97(5):326-8.
2005: Thomas R K; Greulich H; Yuza Y; Lee J C; Tengs T; Feng W; Chen T-H; Nickerson E; Simons J; Egholm M; Rothberg J M; Sellers W R; Meyerson M L
Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():73-81.
2005: Garraway L A; Weir B A; Zhao X; Widlund H; Beroukhim R; Berger A; Rimm D; Rubin M A; Fisher D E; Meyerson M L; Sellers W R
"Lineage addiction" in human cancer: lessons from integrated genomics.
Cold Spring Harbor symposia on quantitative biology 2005;70():25-34.
2004: Berger Raanan; Febbo Phillip G; Majumder Pradip K; Zhao Jean J; Mukherjee Shayan; Signoretti Sabina; Campbell K Thirza; Sellers William R; Roberts Thomas M; Loda Massimo; Golub Todd R; Hahn William C
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.
Cancer research 2004;64(24):8867-75.
2004: Bentires-Alj Mohamed; Paez J Guillermo; David Frank S; Keilhack Heike; Halmos Balazs; Naoki Katsuhiko; Maris John M; Richardson Andrea; Bardelli Alberto; Sugarbaker David J; Richards William G; Du Jinyan; Girard Luc; Minna John D; Loh Mignon L; Fisher David E; Velculescu Victor E; Vogelstein Bert; Meyerson Matthew; Sellers William R; Neel Benjamin G
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Cancer research 2004;64(24):8816-20.
2004: Carroll Peter R; Chan June M L; D'Amico Anthony V; Gelmann Edward P; Iversen Peter; Klotz Laurence; Nelson Joel B; Nelson Peter S; Nelson William G; Oh William K; Rosen Neal; Rubin Mark A; Sandler Howard; Sellers William R; Smith Matthew R; Xu Jianfeng; McMann Mary C; Kantoff Philip W
Fourth International Conference on Innovations and Challenges in Prostate Cancer: Prevention, Detection and Treatment.
The Journal of urology 2004;172(5 Pt 2):S3-5.
2004: Krop Ian; Player Audrey; Tablante Ana; Taylor-Parker Michele; Lahti-Domenici Jaana; Fukuoka Junya; Batra Surinder K; Papadopoulos Nickolas; Richards William G; Sugarbaker David J; Wright Renee L; Shim Judy; Stamey Thomas A; Sellers William R; Loda Massimo; Meyerson Matthew; Hruban Ralph; Jen Jin; Polyak Kornelia
Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types.
Molecular cancer research : MCR 2004;2(9):489-94.
2004: Torres-Arzayus Maria I; Font de Mora Jaime; Yuan Jing; Vazquez Francisca; Bronson Roderick; Rue Montserrat; Sellers William R; Brown Myles
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.
Cancer cell 2004;6(3):263-74.
2004: Korkmaz Ceren G; Korkmaz Kemal S; Manola Judith; Xi Zhijun; Risberg Bjørn; Danielsen Håvard; Kung Janet; Sellers William R; Loda Massimo; Saatcioglu Fahri
Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis.
The Journal of urology 2004;172(3):1134-9.
2004: Jiang Jingrui; Paez J Guillermo; Lee Jeffrey C; Bo Ronghai; Stone Richard M; DeAngelo Daniel J; Galinsky Ilene; Wolpin Brian M; Jonasova Anna; Herman Paula; Fox Edward A; Boggon Titus J; Eck Michael J; Weisberg Ellen; Griffin James D; Gilliland D Gary; Meyerson Matthew; Sellers William R
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Blood 2004;104(6):1855-8.
2004: Allinen Minna; Beroukhim Rameen; Cai Li; Brennan Cameron; Lahti-Domenici Jaana; Huang Haiyan; Porter Dale; Hu Min; Chin Lynda; Richardson Andrea; Schnitt Stuart; Sellers William R; Polyak Kornelia
Molecular characterization of the tumor microenvironment in breast cancer.
Cancer cell 2004;6(1):17-32.
2004: Sansal Isabelle; Sellers William R
The biology and clinical relevance of the PTEN tumor suppressor pathway.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2954-63.
2004: Rubin Mark A; Varambally Sooryanarayana; Beroukhim Rameen; Tomlins Scott A; Rhodes Daniel R; Paris Pamela L; Hofer Matthias D; Storz-Schweizer Martina; Kuefer Rainer; Fletcher Jonathan A; Hsi Bae-Li; Byrne Jennifier A; Pienta Kenneth J; Collins Colin; Sellers William R; Chinnaiyan Arul M
Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer.
Cancer research 2004;64(11):3814-22.
2004: Majumder Pradip K; Febbo Phillip G; Bikoff Rachel; Berger Raanan; Xue Qi; McMahon Louis M; Manola Judith; Brugarolas James; McDonnell Timothy J; Golub Todd R; Loda Massimo; Lane Heidi A; Sellers William R
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Nature medicine 2004;10(6):594-601.
2004: Paez J Guillermo; Jänne Pasi A; Lee Jeffrey C; Tracy Sean; Greulich Heidi; Gabriel Stacey; Herman Paula; Kaye Frederic J; Lindeman Neal; Boggon Titus J; Naoki Katsuhiko; Sasaki Hidefumi; Fujii Yoshitaka; Eck Michael J; Sellers William R; Johnson Bruce E; Meyerson Matthew
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
Science (New York, N.Y.) 2004;304(5676):1497-500.
2004: Zhao Xiaojun; Li Cheng; Paez J Guillermo; Chin Koei; Jänne Pasi A; Chen Tzu-Hsiu; Girard Luc; Minna John; Christiani David; Leo Chris; Gray Joe W; Sellers William R; Meyerson Matthew
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays.
Cancer research 2004;64(9):3060-71.
2004: Lin Ming; Wei Lee-Jen; Sellers William R; Lieberfarb Marshall; Wong Wing Hung; Li Cheng
dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data.
Bioinformatics (Oxford, England) 2004;20(8):1233-40.
2004: Paez J Guillermo; Lin Ming; Beroukhim Rameen; Lee Jeffrey C; Zhao Xiaojun; Richter Daniel J; Gabriel Stacey; Herman Paula; Sasaki Hidefumi; Altshuler David; Li Cheng; Meyerson Matthew; Sellers William R
Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification.
Nucleic acids research 2004;32(9):e71.
2004: Hsieh Andrew C; Bo Ronghai; Manola Judith; Vazquez Francisca; Bare Olivia; Khvorova Anastasia; Scaringe Stephen; Sellers William R
A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.
Nucleic acids research 2004;32(3):893-901.
2003: Kau Tweeny R; Schroeder Frank; Ramaswamy Shivapriya; Wojciechowski Cheryl L; Zhao Jean J; Roberts Thomas M; Clardy Jon; Sellers William R; Silver Pamela A
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Cancer cell 2003;4(6):463-76.
2003: Febbo Phillip G; Sellers William R
Use of expression analysis to predict outcome after radical prostatectomy.
The Journal of urology 2003;170(6 Pt 2):S11-9; discussion S19-20.
2003: Carroll Peter R; Benaron David A; Blackledge George; Coakley Fergus V; D'Amico Anthony V; Higano Celestia S; Iversen Peter; Kattan Michael; Nanus David M; Nelson Joel B; Oh William K; Roach Mack; Sellers William R; Smith Matthew R; McMann Mary Carole; Kantoff Philip W
Third international conference on innovations and challenges in prostate cancer: prevention, detection and treatment.
The Journal of urology 2003;170(6 Pt 2):S3-5.
2003: Brugarolas James B; Vazquez Francisca; Reddy Archana; Sellers William R; Kaelin William G
TSC2 regulates VEGF through mTOR-dependent and -independent pathways.
Cancer cell 2003;4(2):147-58.
2003: Lieberfarb Marshall E; Lin Ming; Lechpammer Mirna; Li Cheng; Tanenbaum David M; Febbo Phillip G; Wright Renée L; Shim Judy; Kantoff Philip W; Loda Massimo; Meyerson Matthew; Sellers William R
Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP.
Cancer research 2003;63(16):4781-5.
2003: Majumder Pradip K; Yeh Jen Jen; George Daniel J; Febbo Phillip G; Kum Jennifer; Xue Qi; Bikoff Rachel; Ma Hongfeng; Kantoff Philip W; Golub Todd R; Loda Massimo; Sellers William R
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7841-6.
2003: Paez Juan; Sellers William R
PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling.
Cancer treatment and research 2003;115():145-67.
2002: Bar-Shira Anat; Pinthus Jehonathan H; Rozovsky Uri; Goldstein Myriam; Sellers William R; Yaron Yuval; Eshhar Zelig; Orr-Urtreger Avi
Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft.
Cancer research 2002;62(23):6803-7.
2002: Sellers William R; Loda Massimo
The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer?
Cancer cell 2002;2(5):349-50.
2002: Ramaswamy Shivapriya; Nakamura Noriaki; Sansal Isabelle; Bergeron Louise; Sellers William R
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.
Cancer cell 2002;2(1):81-91.
2002: Gounari Fotini; Signoretti Sabina; Bronson Roderick; Klein Ludger; Sellers William R; Kum Jennifer; Siermann Anja; Taketo Makoto M; von Boehmer Harald; Khazaie Khashayarsha
Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia.
Oncogene 2002;21(26):4099-107.
2002: Singh Dinesh; Febbo Phillip G; Ross Kenneth; Jackson Donald G; Manola Judith; Ladd Christine; Tamayo Pablo; Renshaw Andrew A; D'Amico Anthony V; Richie Jerome P; Lander Eric S; Loda Massimo; Kantoff Philip W; Golub Todd R; Sellers William R
Gene expression correlates of clinical prostate cancer behavior.
Cancer cell 2002;1(2):203-9.
2002: DiRenzo James; Signoretti Sabina; Nakamura Noriaki; Rivera-Gonzalez Ramon; Sellers William; Loda Massimo; Brown Myles
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
Cancer research 2002;62(1):89-98.
2001: Vazquez F; Grossman S R; Takahashi Y; Rokas M V; Nakamura N; Sellers W R
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.
The Journal of biological chemistry 2001;276(52):48627-30.
2000: Nakamura N; Ramaswamy S; Vazquez F; Signoretti S; Loda M; Sellers W R
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
Molecular and cellular biology 2000;20(23):8969-82.
2000: Miyake S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G
Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle.
Molecular and cellular biology 2000;20(23):8889-902.
2000: Gesbert F; Sellers W R; Signoretti S; Loda M; Griffin J D
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
The Journal of biological chemistry 2000;275(50):39223-30.
2000: Siegert J L; Rushton J J; Sellers W R; Kaelin W G; Robbins P D
Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity.
Oncogene 2000;19(50):5703-11.
2000: Vazquez F; Ramaswamy S; Nakamura N; Sellers W R
Phosphorylation of the PTEN tail regulates protein stability and function.
Molecular and cellular biology 2000;20(14):5010-8.
2000: Vazquez F; Sellers W R
The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.
Biochimica et biophysica acta 2000;1470(1):M21-35.
1999: Sellers W R; Fisher D E
Apoptosis and cancer drug targeting.
The Journal of clinical investigation 1999;104(12):1655-61.
1999: McMenamin M E; Soung P; Perera S; Kaplan I; Loda M; Sellers W R
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.
Cancer research 1999;59(17):4291-6.
1999: Ramaswamy S; Nakamura N; Vazquez F; Batt D B; Perera S; Roberts T M; Sellers W R
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2110-5.
1999: Adams P D; Li X; Sellers W R; Baker K B; Leng X; Harper J W; Taya Y; Kaelin W G
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.
Molecular and cellular biology 1999;19(2):1068-80.
1998: Sellers W R; Novitch B G; Miyake S; Heith A; Otterson G A; Kaye F J; Lassar A B; Kaelin W G
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.
Genes & development 1998;12(1):95-106.
1997: Sellers W R; Kaelin W G
Role of the retinoblastoma protein in the pathogenesis of human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(11):3301-12.
1997: Adams P D; Lopez P; Sellers W R; Kaelin W G
Fluorescence-activated cell sorting of transfected cells.
Methods in enzymology 1997;283():59-72.
1996: Adams P D; Sellers W R; Sharma S K; Wu A D; Nalin C M; Kaelin W G
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors.
Molecular and cellular biology 1996;16(12):6623-33.
1996: Neuman E; Sellers W R; McNeil J A; Lawrence J B; Kaelin W G
Structure and partial genomic sequence of the human E2F1 gene.
Gene 1996;173(2):163-9.
1996: Grafi G; Burnett R J; Helentjaris T; Larkins B A; DeCaprio J A; Sellers W R; Kaelin W G
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8962-7.
1996: Sellers W R; Kaelin W G
RB [corrected] as a modulator of transcription.
Biochimica et biophysica acta 1996;1288(1):M1-5.
1995: Sellers W R; Rodgers J W; Kaelin W G
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11544-8.
1995: Neuman E; Flemington E K; Sellers W R; Kaelin W G
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.
Molecular and cellular biology 1995;15(8):4660.
1995: Xiao Z X; Chen J; Levine A J; Modjtahedi N; Xing J; Sellers W R; Livingston D M
Interaction between the retinoblastoma protein and the oncoprotein MDM2.
Nature 1995;375(6533):694-8.
1995: Qin X Q; Livingston D M; Ewen M; Sellers W R; Arany Z; Kaelin W G
The transcription factor E2F-1 is a downstream target of RB action.
Molecular and cellular biology 1995;15(2):742-55.
1994: Neuman E; Flemington E K; Sellers W R; Kaelin W G
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.
Molecular and cellular biology 1994;14(10):6607-15.
1994: Arany Z; Sellers W R; Livingston D M; Eckner R
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators.
Cell 1994;77(6):799-800.
1994: Eckner R; Arany Z; Ewen M; Sellers W; Livingston D M
The adenovirus E1A-associated 300-kD protein exhibits properties of a transcriptional coactivator and belongs to an evolutionarily conserved family.
Cold Spring Harbor symposia on quantitative biology 1994;59():85-95.
1992: Kaelin W G; Krek W; Sellers W R; DeCaprio J A; Ajchenbaum F; Fuchs C S; Chittenden T; Li Y; Farnham P J; Blanar M A
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.
Cell 1992;70(2):351-64.
1991: Meeker T C; Sellers W; Harvey R; Withers D; Carey K; Xiao H; Block A M; Dadey B; Han T
Cloning of the t(11;14)(q13;q32) translocation breakpoints from two human leukemia cell lines.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(9):733-7.
1990: Meeker T C; Loeb J; Ayres M; Sellers W
The human Pim-1 gene is selectively transcribed in different hemato-lymphoid cell lines in spite of a G + C-rich housekeeping promoter.
Molecular and cellular biology 1990;10(4):1680-8.

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