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Gregg Semenza

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Guoxiang Yuan; Vaddi Damodara Reddy; Gregg L Semenza; Joseph A Garcia; Shakil A Khan; Ganesh K Kumar; Vladislav V Makarenko; Jayasri Nanduri; Ying-Jie Peng; Nanduri R Prabhakar
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.
Daniele M Gilkes; Maimon E Hubbi; Saumendra Bajpai; Pallavi Chaturvedi; Denis Wirtz; Carmen C Wong; Gregg L Semenza
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.
Maimon E Hubbi; Andre Levchenko; Ishrat Ahmed; Hongxia Hu; Gregg L Semenza
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation.

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All Publications

2013: Guoxiang Yuan; Vaddi Damodara Reddy; Gregg L Semenza; Joseph A Garcia; Shakil A Khan; Ganesh K Kumar; Vladislav V Makarenko; Jayasri Nanduri; Ying-Jie Peng; Nanduri R Prabhakar
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):E1788-96.
2013: Daniele M Gilkes; Maimon E Hubbi; Saumendra Bajpai; Pallavi Chaturvedi; Denis Wirtz; Carmen C Wong; Gregg L Semenza
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.
Molecular cancer research : MCR 2013;11(5):456-66.
2013: Maimon E Hubbi; Andre Levchenko; Ishrat Ahmed; Hongxia Hu; Gregg L Semenza
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation.
The Journal of biological chemistry 2013;288(15):10703-14.
2013: Daniele M Gilkes; Saumendra Bajpai; Pallavi Chaturvedi; Denis Wirtz; Gregg L Semenza
Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts.
The Journal of biological chemistry 2013;288(15):10819-29.
2013: Gregg L Semenza
Advances in cancer biology and therapy.
Journal of molecular medicine (Berlin, Germany) 2013;91(4):409.
2013: Sarah Pisarcik; Gregg L Semenza; Wenju Lu; Julie Maylor; JIM SYLVESTER; Clark Undem; Xin Yun; Larissa A Shimoda
Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.
American journal of physiology. Lung cellular and molecular physiology 2013;304(8):L549-61.
2013: Gregg L Semenza
Blood vessels, disease pathogenesis, and novel therapies.
Journal of molecular medicine (Berlin, Germany) 2013;91(3):283.
2013: Maimon E Hubbi; Deok-Ho Kim; Andre Levchenko; Weibo Luo; Sergio Rey; Chi Dang; Daniele M Gilkes; Carmen C Wong; Gregg L Semenza
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication.
Science signaling 2013;6(262):ra10.
2013: Pallavi Chaturvedi; Daniele M Gilkes; Andre Levchenko; Weibo Luo; Luana Schito; Naoharu Takano; Hong Wei; Carmen Chak Lui Wong; Huafeng Zhang; Gregg L Semenza
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
The Journal of clinical investigation 2013;123(1):189-205.
2012: Weibo Luo; Akhilesh Pandey; Ryan Chang; Jun Zhong; Gregg L Semenza
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(49):E3367-76.
2012: Weibo Luo; Gregg L Semenza
Emerging roles of PKM2 in cell metabolism and cancer progression.
Trends in endocrinology and metabolism: TEM 2012;23(11):560-6.
2012: Luana Schito; Sergio Rey; Andrea Russo; Matteo A Russo; Marco Tafani; Carmen Chak-Lui Wong; Huafeng Zhang; Gregg L Semenza
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):E2707-16.
2012: Gregg L Semenza
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Trends in molecular medicine 2012;18(9):534-43.
2012: Nanduri R Prabhakar; Gregg L Semenza
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Physiological reviews 2012;92(3):967-1003.
2012: Carmen Chak-Lui Wong; Huafeng Zhang; Hong Wei; Pallavi Chaturvedi; Jasper Chen; Daniele M Gilkes; Maimon E Hubbi; Gregg L Semenza
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis.
Journal of molecular medicine (Berlin, Germany) 2012;90(7):803-15.
2012: KAKALI SARKAR; Zheqing Cai; Medha S Darshan; Karen Fox-Talbot; Frank J Gonzalez; RIGU GUPTA; Nirmal Parajuli; Gregg L Semenza
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10504-9.
2012: ROSELLE ABRAHAM; Junaid Afzal; Eun Hyun Ahn; Connie Chang; John Downey; Maimon E Hubbi; Deok-Ho Kim; Arnab Kundu; Sergio Rey; Gregg L Semenza; Andre Levchenko
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors.
Science signaling 2012;5(227):ra41.
2012: Huafeng Zhang; L Zhen; Saraswati Sukumar; H Wei; Paul T Winnard; C C L Wong; P Chaturvedi; J Chen; D M Gilkes; P Korangath; Balaji Krishnamachary; Wayne Mitzner; Venu Raman; L Schito; Gregg L Semenza
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.
Oncogene 2012;31(14):1757-70.
2012: Hong Wei; Dongmei Xing; CHARLES STEENBERGEN; Djahida Bedja; Jasper Chen; Shaoping Chen; Harry C Dietz; Karen Fox-Talbot; Kathleen L Gabrielson; John W Harmon; David A Kass; Norimichi Koitabashi; Rosanne Rouf; Gregg L Semenza
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):E841-50.
2012: Gregg L Semenza
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.
Trends in pharmacological sciences 2012;33(4):207-14.
2012: Gregg L Semenza; Nanduri R Prabhakar
Gas biology: small molecular medicine.
Journal of molecular medicine (Berlin, Germany) 2012;90(3):213-5.
2012: Nanduri R Prabhakar; Gregg L Semenza
Gaseous messengers in oxygen sensing.
Journal of molecular medicine (Berlin, Germany) 2012;90(3):265-72.
2012: Maimon E Hubbi; Jin Hyen Baek; Daniele M Gilkes; Gregg L Semenza
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
The Journal of biological chemistry 2012;287(9):6139-49.
2012: Jayasri Nanduri; Anita Pawar; Ying-Jie Peng; Aaron P Fox; Lucy A Godley; Shakil A Khan; Brian Kinsman; Ganesh K Kumar; Vladislav V Makarenko; Vaddi Damodara Reddy; Gregg L Semenza; Ning Wang; Guoxiang Yuan; Xin Zhang; Nanduri R Prabhakar
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2515-20.
2012: Gregg L Semenza
Hypoxia-inducible factors in physiology and medicine.
Cell 2012;148(3):399-408.
2012: Edsel M Abud; Julie Maylor; Allen C Myers; Arjun Punjabi; Gregg L Semenza; JIM SYLVESTER; Clark Undem; Ari L Zaiman; Larissa A Shimoda
Digoxin inhibits development of hypoxic pulmonary hypertension in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):1239-44.
2012: Gregg L Semenza; Nanduri R Prabhakar
The role of hypoxia-inducible factors in oxygen sensing by the carotid body.
Advances in experimental medicine and biology 2012;758():1-5.
2012: Balaji Krishnamachary; Yelena Mironchik; Sridhar Nimmagadda ; Marie-France Penet; Martin G Pomper; Venu Raman; Gregg L Semenza; Meiyappan Solaiyappan; Zaver M Bhujwalla
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
PloS one 2012;7(8):e44078.
2012: KAKALI SARKAR; Amanda V Cardona; John W Harmon; Lixin Liu; Raul Sebastian; Junkai Du; Karen Fox-Talbot; Yee Sun Tan; Xianjie Zhang; Frank J Gonzalez; Sergio Rey; Guy P Marti; Frank Lay; Gregg L Semenza
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.
Cardiovascular research 2012;93(1):162-9.
2011: Guoxiang Yuan; Gregg L Semenza; Shakil A Khan; Weibo Luo; Jayasri Nanduri; Nanduri R Prabhakar
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Journal of cellular physiology 2011;226(11):2925-33.
2011: Toshio Suda; Keiyo Takubo; Gregg L Semenza
Metabolic regulation of hematopoietic stem cells in the hypoxic niche.
Cell stem cell 2011;9(4):298-310.
2011: Xianjie Zhang; Efstathia Andrikopoulou; Karen Fox-Talbot; Guy P Marti; Sergio Rey; KAKALI SARKAR; Raul Sebastian; Gregg L Semenza; John W Harmon
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.
Journal of molecular medicine (Berlin, Germany) 2011;89(10):985-95.
2011: Carmen Chak-Lui Wong; Chun-Ming Wong; Huafeng Zhang; Hong Wei; Denis Wirtz; Pallavi Chaturvedi; Jasper Chen; Stephanie I Fraley; Daniele M Gilkes; Ui-Soon Khoo; Irene Oi-Lin Ng; Gregg L Semenza
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16369-74.
2011: Hisanori Hattori; Tetsuji Murase; Kosuke Narise; Kensuke Okuda; Gregg L Semenza; Yuki Shigetsura; Hideko Nagasawa
Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis.
Bioorganic & medicinal chemistry 2011;19(18):5392-401.
2011: Eric V Dang; Juan Fu; Dilini Jinasena; Young Kim; Weibo Luo; Joseph Barbi; Zachary Bordman; Chi Dang; Drew M Pardoll; Gregg L Semenza; Larissa A Shimoda; Suzanne Topalian; Huang-Yu Yang; Hung-Rong Yen; Hong Yu; Karen I Zeller; Ying Zheng; Fan Pan
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell 2011;146(5):772-84.
2011: Gregg L Semenza
Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery.
American journal of physiology. Cell physiology 2011;301(3):C550-2.
2011: Gregg L Semenza
Oxygen sensing, homeostasis, and disease.
The New England journal of medicine 2011;365(6):537-47.
2011: Weibo Luo; Gregg L Semenza
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells.
Oncotarget 2011;2(7):551-6.
2011: Tirumalai Rangasamy; Gregg L Semenza; Steve N Georas
What is hypoxia-inducible factor-1 doing in the allergic lung?
Allergy 2011;66(7):815-7.
2011: Gregg L Semenza
Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning.
Biochimica et biophysica acta 2011;1813(7):1263-8.
2011: Maimon E Hubbi; Weibo Luo; Jin Hyen Baek; Gregg L Semenza
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Molecular cell 2011;42(5):700-12.
2011: Xinguo Jiang; Mohammad A Khan; Wen Tian; Joshua Beilke; Ramesh Natarajan; Jon Kosek; Mervin C Yoder; Gregg L Semenza; Mark R Nicolls
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.
The Journal of clinical investigation 2011;121(6):2336-49.
2011: Weibo Luo; Hongxia Hu; Ryan Chang; Jun Zhong; Matthew Knabel; Robert O'Meally; Robert N Cole; Akhilesh Pandey; Gregg L Semenza
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Cell 2011;145(5):732-44.
2011: Sergio Rey; Weibo Luo; Larissa A Shimoda; Gregg L Semenza
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue.
Blood 2011;117(18):4988-98.
2011: Kolenkode B Kannan; Iriana Colorado; Diego Reino; David Palange; Qi Lu; Xiaofa Qin; Billy Abungu; Anthony C Watkins; Francis J Caputo; Da-Zhong Xu; Gregg L Semenza; Edwin A Deitch; Rena Feinman
Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(5):G853-61.
2011: Sanjay C Keswani; MARTA BOSCH; Nicole Reed; Angela Fischer; Gregg L Semenza; Ahmet Höke
Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4986-90.
2011: Gregg L Semenza
A return to cancer metabolism.
Journal of molecular medicine (Berlin, Germany) 2011;89(3):203-4.
2011: Ying-Jie Peng; Jayasri Nanduri; Shakil Khan; Guoxiang Yuan; Ning Wang; Brian Kinsman; Damodara R Vaddi; Ganesh K Kumar; Joseph A Garcia; Gregg L Semenza; Nanduri R Prabhakar
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):3065-70.
2011: Gregg L Semenza
American Journal of Physiology-Cell Physiology theme: hypoxia.
American journal of physiology. Cell physiology 2011;300(2):C225.
2011: Larissa A Shimoda; Gregg L Semenza
HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.
American journal of respiratory and critical care medicine 2011;183(2):152-6.
2011: Gregg L Semenza
Regulation of metabolism by hypoxia-inducible factor 1.
Cold Spring Harbor symposia on quantitative biology 2011;76():347-53.
2010: Rena Feinman; Edwin A Deitch; Anthony C Watkins; Billy Abungu; Iriana Colorado; Kolenkode B Kannan; Sharvil U Sheth; Francis J Caputo; Qi Lu; Madhuri Ramanathan; Shirhan Attan; Chirag D Badami; Danielle Doucet; Dimitrios Barlos; MARTA BOSCH; Gregg L Semenza; Da-Zhong Xu
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G833-43.
2010: Jason S Lee; Yunho Kim; Ik Soo Kim; Bogyou Kim; Hee June Choi; Ji Min Lee; Hi-Jai R Shin; Jung Hwa Kim; Ji-Young Kim; Sang-Beom Seo; Ho Lee; Olivier Binda; Or Gozani; Gregg L Semenza; Minhyung Kim; Keun Il Kim; Daehee Hwang; Sung Hee Baek
Negative regulation of hypoxic responses via induced Reptin methylation.
Molecular cell 2010;39(1):71-85.
2010: Tsunehiko Yoshida; Huafeng Zhang; Takeshi Iwase; Jikui Shen; Gregg L Semenza; Peter A Campochiaro
Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(6):1759-67.
2010: Gregg L Semenza
Oxygen homeostasis.
Wiley interdisciplinary reviews. Systems biology and medicine 2010;2(3):336-61.
2010: Sergio Rey; Gregg L Semenza
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
Cardiovascular research 2010;86(2):236-42.
2010: Donghoon Yoon; David V Okhotin; Bumjun Kim; Yulia Okhotina; Daniel J Okhotin; Galina Y Miasnikova; Adelina I Sergueeva; Lydia A Polyakova; Alexei Maslow; Yonggu Lee; Gregg L Semenza; Josef T Prchal; Victor Roland Gordeuk
Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha.
Journal of molecular medicine (Berlin, Germany) 2010;88(5):523-30.
2010: Gregg L Semenza
Vascular responses to hypoxia and ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):648-52.
2010: Xianjie Zhang; Xiaofei Wei; Lixin Liu; Guy P Marti; Mohammed S Ghanamah; Muhammad J Arshad; Lori Strom; Robert Spence; James Jeng; Stephen M Milner; John W Harmon; Gregg L Semenza
Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells.
Archives of surgery (Chicago, Ill. : 1960) 2010;145(3):259-66.
2010: Xianjie Zhang; Lixin Liu; Xiaofei Wei; Yee Sun Tan; Lana Tong; Ryan Chang; Mohammed S Ghanamah; Maura Reinblatt; Guy P Marti; John W Harmon; Gregg L Semenza
Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2010;18(2):193-201.
2010: Weibo Luo; Jun Zhong; Ryan Chang; Hongxia Hu; Akhilesh Pandey; Gregg L Semenza
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
The Journal of biological chemistry 2010;285(6):3651-63.
2010: Gregg L Semenza
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.
Oncogene 2010;29(5):625-34.
2010: Anne Le; Charles R Cooper; Arvin M Gouw; Ramani Dinavahi; Anirban Maitra; Lorraine M Deck; Robert E Royer; David L Vander Jagt; Gregg L Semenza; Chi Dang
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2037-42.
2010: Gregg L Semenza
HIF-1: upstream and downstream of cancer metabolism.
Current opinion in genetics & development 2010;20(1):51-6.
2010: Peter Ugocsai; Antonia Hohenstatt; György Paragh; Gerhard Liebisch; Thomas Langmann; Zsuzsanna Wolf; Thomas Weiss; Peter Groitl; Thomas Dobner; Piotr Kasprzak; László Göbölös; Andreas Falkert; Birgit Seelbach-Goebel; Alexandra Gellhaus; Elke Winterhager; Markus Schmidt; Gregg L Semenza; Gerd Schmitz
HIF-1beta determines ABCA1 expression under hypoxia in human macrophages.
The international journal of biochemistry & cell biology 2010;42(2):241-52.
2010: Hidefumi Kojima; Ayano Kobayashi; Daisuke Sakurai; Yumiko Kanno; Hidenori Hase; Riichi Takahashi; Yoshikazu Totsuka; Gregg L Semenza; Michail V Sitkovsky; Tetsuji Kobata
Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):154-63.
2010: Yongli Guan; Kavitha Ramasamy Reddy; Qiqing Zhu; Yifei Li; KangAe Lee; Priya Weerasinghe; Josef Prchal; Gregg L Semenza; Naijie Jing
G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(1):188-97.
2010: Jessica Roman; Tirumalai Rangasamy; Jia Guo; Siva Sugunan; Nida Meednu; Gopinath Packirisamy; Larissa A Shimoda; Amit Golding; Gregg L Semenza; Steve N Georas
T-cell activation under hypoxic conditions enhances IFN-gamma secretion.
American journal of respiratory cell and molecular biology 2010;42(1):123-8.
2009: Sergio Rey; KangAe Lee; C Joanne Wang; Kshitiz Gupta; Shaoping Chen; Alexandra McMillan; Nupura Bhise; Andre Levchenko; Gregg L Semenza
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20399-404.
2009: KAKALI SARKAR; Karen Fox-Talbot; CHARLES STEENBERGEN; MARTA BOSCH; Gregg L Semenza
Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18769-74.
2009: Menghang Xia; Ruili Huang; Yi Sun; Gregg L Semenza; Shelley Force Aldred; Kristine L Witt; James Inglese; Raymond R Tice; Christopher P Austin
Identification of chemical compounds that induce HIF-1alpha activity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):153-63.
2009: KangAe Lee; Huafeng Zhang; Zheng (David) Qian; Sergio Rey; Jun O Liu; Gregg L Semenza
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17910-5.
2009: Gregg L Semenza
Regulation of vascularization by hypoxia-inducible factor 1.
Annals of the New York Academy of Sciences 2009;1177():2-8.
2009: Jamie Wikenheiser; Julie A Wolfram; Madhusudhana Gargesha; Ke Yang; Ganga Karunamuni; David L Wilson; Gregg L Semenza; Faton H Agani; Steven Fisher; Nicole Ward; Michiko Watanabe
Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(10):2688-700.
2009: Gregg L Semenza
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
Blood 2009;114(10):2015-9.
2009: Ernestina Schipani; Christa Maes; Geert Carmeliet; Gregg L Semenza
Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(8):1347-53.
2009: Ambreena Siddiq; Leila R Aminova; Carol M Troy; Kyungsun Suh; Zachary Messer; Gregg L Semenza; Rajiv R Ratan
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(27):8828-38.
2009: Gregg L Semenza
Recent advances in vascular biology and their clinical relevance.
Journal of molecular medicine (Berlin, Germany) 2009;87(6):547-8.
2009: Shinae Kizaka-Kondoh; Satoshi Itasaka; Lihua Zeng; Shotaro Tanaka; Tao Zhao; Yumi Takahashi; Keiko Shibuya; Kiichi Hirota; Gregg L Semenza; Masahiro Hiraoka
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3433-41.
2009: Gregg L Semenza
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Physiology (Bethesda, Md.) 2009;24():97-106.
2009: KangAe Lee; Zheng (David) Qian; Sergio Rey; Hong Wei; Jun O Liu; Gregg L Semenza
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2353-8.
2009: Gregg L Semenza
Regulation of cancer cell metabolism by hypoxia-inducible factor 1.
Seminars in cancer biology 2009;19(1):12-6.
2009: Gregg L Semenza
HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery.
Current pharmaceutical design 2009;15(33):3839-43.
2009: Jia Guo; Wenju Lu; Larissa A Shimoda; Gregg L Semenza; Steve N Georas
Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice.
International archives of allergy and immunology 2009;149(2):98-102.
2009: Detlev Ganten; Gregg L Semenza; Christiane Nolte
Fostering trust-- Mol Med's scientific integrity policy.
Journal of molecular medicine (Berlin, Germany) 2009;87(1):1-2.
2008: Huafeng Zhang; Zheng (David) Qian; Yee Sun Tan; Kangae Lee; Ping Gao; yunzhao richard ren; Sergio Rey; Hans-Joerg Hammers; Daniel Chang; Roberto Pili; Chi Dang; Jun O Liu; Gregg L Semenza
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(50):19579-86.
2008: Gregg L Semenza
Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(24):7969-70.
2008: Jayasri Nanduri; Guoxiang Yuan; Ganesh Kumar; Gregg L Semenza; Nanduri R Prabhakar
Transcriptional responses to intermittent hypoxia.
Respiratory physiology & neurobiology 2008;164(1-2):277-81.
2008: Rajiv R Ratan; Ambreena Siddiq; Leila Aminova; Brett Langley; Stephen McConoughey; Ksenia Karpisheva; Hsin-Hwa Lee; Thomas Carmichael; Harley Kornblum; Giovanni Coppola; Daniel Geschwind; Ahmet Hoke; Natalya Smirnova; Cameron Rink; Sashwati Roy; Chandan K Sen; Michael S Beattie; Ron P Hart; Martin Grumet; Dongming Sun; Robert S Freeman; Gregg L Semenza; Irina Gazaryan
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Annals of the New York Academy of Sciences 2008;1147():383-94.
2008: Gregg L Semenza
Tumor metabolism: cancer cells give and take lactate.
The Journal of clinical investigation 2008;118(12):3835-7.
2008: Guoxiang Yuan; Jayasri Nanduri; Shakil Khan; Gregg L Semenza; Nanduri R Prabhakar
Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
Journal of cellular physiology 2008;217(3):674-85.
2008: Lixin Liu; guy marti; Xiaofei Wei; Xianjie Zhang; Huafeng Zhang; Ye V Liu; Manuel Nastai; Gregg L Semenza; John W Harmon
Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells.
Journal of cellular physiology 2008;217(2):319-27.
2008: Gregg L Semenza
Hypoxia-inducible factor 1 and cancer pathogenesis.
IUBMB life 2008;60(9):591-7.
2008: Richard Sullivan; Geneviève C Paré; Lisa J Frederiksen; Gregg L Semenza; Charles H Graham
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity.
Molecular cancer therapeutics 2008;7(7):1961-73.
2008: Huafeng Zhang; Gregg L Semenza
The expanding universe of hypoxia.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):739-46.
2008: Gregg L Semenza
A new weapon for attacking tumor blood vessels.
The New England journal of medicine 2008;358(19):2066-7.
2008: Gregg L Semenza
Mitochondrial autophagy: life and breath of the cell.
Autophagy 2008;4(4):534-6.
2008: Kenichiro Nishi; Tomoyuki Oda; Satoshi Takabuchi; Seiko Oda; Kazuhiko Fukuda; Takehiko Adachi; Gregg L Semenza; Koh Shingu; Kiichi Hirota
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner.
Antioxidants & redox signaling 2008;10(5):983-95.
2008: Gregg L Semenza
O2 sensing: only skin deep?
Cell 2008;133(2):206-8.
2008: Huafeng Zhang; MARTA BOSCH; Larissa A Shimoda; Yee Sun Tan; Jin Hyen Baek; Jacob B Wesley; Frank J Gonzalez; Gregg L Semenza
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
The Journal of biological chemistry 2008;283(16):10892-903.
2008: Motohide Kimura; Satoshi Takabuchi; Tomoharu Tanaka; Miyahiko Murata; Kenichiro Nishi; Seiko Oda; Tomoyuki Oda; Michiyuki Kanai; Kazuhiko Fukuda; Shinae Kizaka-Kondoh; Takehiko Adachi; Arimichi Takabayashi; Gregg L Semenza; Kiichi Hirota
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems.
The Biochemical journal 2008;411(1):97-105.
2008: Mingjia Tan; Q Gu; H He; Deepika Pamarthy; Gregg L Semenza; Yi Sun
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation.
Oncogene 2008;27(10):1404-11.
2008: E Miles Whitman; Sarah Pisarcik; Trevor Luke; Michele Fallon; Jian Wang; JIM SYLVESTER; Gregg L Semenza; Larissa A Shimoda
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes.
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L309-18.
2008: Zheqing Cai; Hua Zhong; MARTA BOSCH; Karen Fox-Talbot; Lei Wang; Chiming Wei; Michael A Trush; Gregg L Semenza
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha.
Cardiovascular research 2008;77(3):463-70.
2008: Seiko Oda; Tomoyuki Oda; Kenichiro Nishi; Satoshi Takabuchi; Takuhiko Wakamatsu; Tomoharu Tanaka; Takehiko Adachi; Kazuhiko Fukuda; Gregg L Semenza; Kiichi Hirota
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner.
PloS one 2008;3(5):e2215.
2007: Ye V Liu; Maimon E Hubbi; Fan Pan; Karin R McDonald; Malini Mansharamani; Robert N Cole; Jun O Liu; Gregg L Semenza
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
The Journal of biological chemistry 2007;282(51):37064-73.
2007: MARTA BOSCH; Hiroaki Okuyama; Jacob B Wesley; KAKALI SARKAR; Hideo Kimura; Ye V Liu; Huafeng Zhang; Marianne Strazza; Sergio Rey; Lindsey Savino; Yi Fu Zhou; Karin R McDonald; Youn Na; Scott Vandiver; Alireza Rabi; Yuval Shaked; Robert S Kerbel; Theresa M Lavallee; Gregg L Semenza
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia.
Circulation research 2007;101(12):1310-8.
2007: Gregg L Semenza
Hypoxia and human disease-and the Journal of Molecular Medicine.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1293-4.
2007: Jin Hyen Baek; Ye V Liu; Karin R McDonald; Jacob B Wesley; Huafeng Zhang; Gregg L Semenza
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
The Journal of biological chemistry 2007;282(46):33358-66.
2007: Gregg L Semenza
Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling.
Journal of cellular biochemistry 2007;102(4):840-7.
2007: Jung-whan Kim; Ping Gao; Yen-Chun Liu; Gregg L Semenza; Chi Dang
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.
Molecular and cellular biology 2007;27(21):7381-93.
2007: Gregg L Semenza
Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.
Experimental physiology 2007;92(6):988-91.
2007: Gregg L Semenza
Hypoxia-inducible factor 1 (HIF-1) pathway.
Science's STKE : signal transduction knowledge environment 2007;2007(407):cm8.
2007: Gregg L Semenza
Life with oxygen.
Science (New York, N.Y.) 2007;318(5847):62-4.
2007: Gregg L Semenza
Evaluation of HIF-1 inhibitors as anticancer agents.
Drug discovery today 2007;12(19-20):853-9.
2007: Ping Gao; Huafeng Zhang; Ramani Dinavahi; Feng Li; Yan Xiang; Venu Raman; Zaver M Bhujwalla; Dean W Felsher; Linzhao Cheng; Jonathan Pevsner; Linda A Lee; Gregg L Semenza; Chi Dang
HIF-dependent antitumorigenic effect of antioxidants in vivo.
Cancer cell 2007;12(3):230-8.
2007: Gregg L Semenza; Nanduri R Prabhakar
HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia.
Antioxidants & redox signaling 2007;9(9):1391-6.
2007: Nanduri R Prabhakar; Ganesh Kumar; Jayasri Nanduri; Gregg L Semenza
ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.
Antioxidants & redox signaling 2007;9(9):1397-403.
2007: Mariko Tomita; Gregg L Semenza; Canine Michiels; Takehiro Matsuda; Jun-Nosuke Uchihara; Taeko Okudaira; Yuetsu Tanaka; Naoya Taira; Kazuiku Ohshiro; Naoki Mori
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells.
The Biochemical journal 2007;406(2):317-23.
2007: Jin Hyen Baek; Ye V Liu; Karin R McDonald; Jacob B Wesley; Maimon E Hubbi; Hweejo Byun; Gregg L Semenza
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
The Journal of biological chemistry 2007;282(32):23572-80.
2007: Gregg L Semenza
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.
The Biochemical journal 2007;405(1):1-9.
2007: Gregg L Semenza
HIF-1 mediates the Warburg effect in clear cell renal carcinoma.
Journal of bioenergetics and biomembranes 2007;39(3):231-4.
2007: Gregg L Semenza
Hypoxia and cancer.
Cancer metastasis reviews 2007;26(2):223-4.
2007: Huafeng Zhang; Ping Gao; Ryo Fukuda; Ganesh Kumar; Balaji Krishnamachary; Karen I Zeller; Chi Dang; Gregg L Semenza
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Cancer cell 2007;11(5):407-20.
2007: Ryo Fukuda; Huafeng Zhang; Jung-whan Kim; Larissa A Shimoda; Chi Dang; Gregg L Semenza
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
Cell 2007;129(1):111-22.
2007: Ye V Liu; Gregg L Semenza
RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
Cell cycle (Georgetown, Tex.) 2007;6(6):656-9.
2007: David E Komatsu; MARTA BOSCH; Gregg L Semenza; michael hadjiargyrou
Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(3):366-74.
2007: Ye V Liu; Jin Hyen Baek; Huafeng Zhang; roberto diez; Robert N Cole; Gregg L Semenza
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.
Molecular cell 2007;25(2):207-17.
2007: Balaji Krishnamachary; Gregg L Semenza
Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis.
Methods in enzymology 2007;435():347-54.
2007: Bing Xu; Yong-Qiu Doughman; Mona Turakhia; Weihong Jiang; Chad E Landsettle; Faton H Agani; Gregg L Semenza; Michiko Watanabe; Yu-Chung Yang
Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity.
Developmental biology 2007;301(1):130-40.
2006: Gregg L Semenza
Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression.
Molecular pharmacology 2006;70(6):1841-3.
2006: Ying-Jie Peng; Guoxiang Yuan; Deviprasadh Ramakrishnan; SURESH SHARMA; MARTA BOSCH; Ganesh Kumar; Gregg L Semenza; Nanduri R Prabhakar
Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.
The Journal of physiology 2006;577(Pt 2):705-16.
2006: Yi Fu Zhou; MARTA BOSCH; Hiroaki Okuyama; Balaji Krishnamachary; Hideo Kimura; Li Zhang; David L Huso; Gregg L Semenza
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells.
Cancer research 2006;66(22):10849-54.
2006: Zheqing Cai; Gregg L Semenza
Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus?
Circulation research 2006;99(10):e86.
2006: Larissa A Shimoda; Michele Fallon; Sarah Pisarcik; Jian Wang; Gregg L Semenza
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L941-9.
2006: James L Tatum; Gary J Kelloff; Robert J Gillies; Jeffrey M Arbeit; J Martin Brown; K.S. Chao; J Donald Chapman; William Eckelman; Anthony W Fyles; Amato J Giaccia; Richard P Hill; Cameron J Koch; Murali K Cherukuri; Kenneth A Krohn; Jason S Lewis; Ralph P Mason; Giovanni Melillo; Anwar R Padhani; Garth Powis; Joseph G Rajendran; Richard Reba; Simon P Robinson; Gregg L Semenza; Harold M Swartz; Peter Vaupel; David Yang; Barbara Croft; John Hoffman; Guoying Liu; Helen Stone; Daniel Sullivan
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.
International journal of radiation biology 2006;82(10):699-757.
2006: Gregg L Semenza
Hypoxia pathway linked to kidney failure.
Nature medicine 2006;12(9):996-7.
2006: Donghoon Yoon; Yves D Pastore; Vladimir Divoky; Enli Liu; Agnieszka E Mlodnicka; Karin Rainey; Prem Ponka; Gregg L Semenza; Armin Schumacher; Josef T Prchal
Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.
The Journal of biological chemistry 2006;281(35):25703-11.
2006: Gregg L Semenza
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.
Experimental physiology 2006;91(5):803-6.
2006: Kiichi Hirota; Gregg L Semenza
Regulation of angiogenesis by hypoxia-inducible factor 1.
Critical reviews in oncology/hematology 2006;59(1):15-26.
2006: Tomoyuki Oda; Kiichi Hirota; Kenichiro Nishi; Satoshi Takabuchi; Seiko Oda; Hiroko Yamada; Toshiyuki Arai; Kazuhiko Fukuda; Toru Kita; Takehiko Adachi; Gregg L Semenza; Ryuji Nohara
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
American journal of physiology. Cell physiology 2006;291(1):C104-13.
2006: Sukhamay Lahiri; Arijit Roy; Santhosh M Baby; Toshinori Hoshi; Gregg L Semenza; Nanduri R Prabhakar
Oxygen sensing in the body.
Progress in biophysics and molecular biology 2006;91(3):249-86.
2006: Jian Wang; Letitia Weigand; Wenju Lu; JIM SYLVESTER; Gregg L Semenza; Larissa A Shimoda
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells.
Circulation research 2006;98(12):1528-37.
2006: Hiroaki Okuyama; Balaji Krishnamachary; Yi Fu Zhou; Hideko Nagasawa; MARTA BOSCH; Gregg L Semenza
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
The Journal of biological chemistry 2006;281(22):15554-63.
2006: Gregg L Semenza
VHL and p53: tumor suppressors team up to prevent cancer.
Molecular cell 2006;22(4):437-9.
2006: Jianguo Li; MARTA BOSCH; Ashika Nanayakkara; VLADIMIR SAVRANSKY; Susan K Fried; Gregg L Semenza; Vsevolod Y Polotsky
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Physiological genomics 2006;25(3):450-7.
2006: Gregg L Semenza
Therapeutic angiogenesis: another passing phase?
Circulation research 2006;98(9):1115-6.
2006: Giovanni Melillo; Gregg L Semenza
Meeting report: exploiting the tumor microenvironment for therapeutics.
Cancer research 2006;66(9):4558-60.
2006: Gregg L Semenza
Development of novel therapeutic strategies that target HIF-1.
Expert opinion on therapeutic targets 2006;10(2):267-80.
2006: Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi Dang
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
Cell metabolism 2006;3(3):177-85.
2006: Balaji Krishnamachary; David Zagzag; Hideko Nagasawa; Karin Rainey; Hiroaki Okuyama; Jin Hyen Baek; Gregg L Semenza
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Cancer research 2006;66(5):2725-31.
2006: Gregg L Semenza; Larissa A Shimoda; Nanduri R Prabhakar
Regulation of gene expression by HIF-1.
Novartis Foundation symposium 2006;272():2-8; discussion 8-14, 33-6.
2005: Zheqing Cai; Gregg L Semenza
PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning.
Circulation research 2005;97(12):1351-9.
2005: Kiichi Hirota; Gregg L Semenza
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.
Biochemical and biophysical research communications 2005;338(1):610-6.
2005: Gregg L Semenza
Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology.
Chest 2005;128(6 Suppl):592S-594S.
2005: Gregg L Semenza
New insights into nNOS regulation of vascular homeostasis.
The Journal of clinical investigation 2005;115(11):2976-8.
2005: Tarak H Patel; Hideo Kimura; Clifford Weiss; Gregg L Semenza; Lawrence Vincent Hofmann
Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia.
Cardiovascular research 2005;68(1):144-54.
2005: Alina Maloyan; Luba Eli-Berchoer; Gregg L Semenza; Gary Gerstenblith; Michael D Stern; Michal Horowitz
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart.
Physiological genomics 2005;23(1):79-88.
2005: Qing Xu; Jon Briggs; Sungman Park; Guilian Niu; Marcin Kortylewski; Shumin Zhang; Tanya Gritsko; James Turkson; Heidi Kay; Gregg L Semenza; Jin Q Cheng; Richard Jove; Hua Yu
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
Oncogene 2005;24(36):5552-60.
2005: Jon R Resar; Ariel Roguin; Jeffery Voner; Khurram Nasir; Thomas A Hennebry; Julie M Miller; Roxann G Ingersoll; Laura M Kasch; Gregg L Semenza
Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease.
Chest 2005;128(2):787-91.
2005: David Zagzag; Balaji Krishnamachary; Herman Yee; Hiroaki Okuyama; Luis Chiriboga; Mehboob Ali; Jonathan Melamed; Gregg L Semenza
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Cancer research 2005;65(14):6178-88.
2005: Astrid E Greijer; Petra van Der Groep; D Kemming; Avi Shvarts; Gregg L Semenza; Gerrit A Meijer; Mark A van de Wiel; Jeroen A M Belien; Paulus van Diest; ELSKEN VAN DER WALL
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).
The Journal of pathology 2005;206(3):291-304.
2005: Michael J Gray; Jing Zhang; Lee M Ellis; Gregg L Semenza; Douglas B Evans; Stephanie S Watowich; Gary E Gallick
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Oncogene 2005;24(19):3110-20.
2005: Jin Hyen Baek; Patrick C Mahon; Jane Oh; Brian Kelly; Balaji Krishnamachary; Mia Pearson; Denise A Chan; Amato J Giaccia; Gregg L Semenza
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Molecular cell 2005;17(4):503-12.
2005: Guoxiang Yuan; Jayasri Nanduri; Raman Bhasker; Gregg L Semenza; Nanduri R Prabhakar
Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
The Journal of biological chemistry 2005;280(6):4321-8.
2005: Dominador J Manalo; Ashley Rowan; Tera Lavoie; Lakshmi Natarajan; Brian D Kelly; Shui Q Ye; Joe G. N. Garcia; Gregg L Semenza
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.
Blood 2005;105(2):659-69.
2005: Gregg L Semenza
Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1.
Proceedings of the American Thoracic Society 2005;2(1):68-70.
2004: Satoshi Takabuchi; Kiichi Hirota; Kenichiro Nishi; Seiko Oda; Tomoyuki Oda; Koh Shingu; Arimichi Takabayashi; Takehiko Adachi; Gregg L Semenza; Kazuhiko Fukuda
The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner.
FEBS letters 2004;577(3):434-8.
2004: Satoshi Takabuchi; Kiichi Hirota; Kenichiro Nishi; Seiko Oda; Tomoyuki Oda; Koh Shingu; Arimichi Takabayashi; Takehiko Adachi; Gregg L Semenza; Kazuhiko Fukuda
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway.
Biochemical and biophysical research communications 2004;324(1):417-23.
2004: Kiichi Hirota; Ryo Fukuda; Satoshi Takabuchi; Shinae Kizaka-Kondoh; Takehiko Adachi; Kazuhiko Fukuda; Gregg L Semenza
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.
The Journal of biological chemistry 2004;279(40):41521-8.
2004: Gregg L Semenza
Hydroxylation of HIF-1: oxygen sensing at the molecular level.
Physiology (Bethesda, Md.) 2004;19():176-82.
2004: Oliver Stoeltzing; Marya F McCarty; Jane S Wey; Fan Fan; Wenbiao Liu; Anna Belcheva; Corazon D Bucana; Gregg L Semenza; Lee M Ellis
Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.
Journal of the National Cancer Institute 2004;96(12):946-56.
2004: Zheqing Cai; Gregg L Semenza
Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury.
Circulation 2004;109(17):2050-3.
2004: Gregg L Semenza
Intratumoral hypoxia, radiation resistance, and HIF-1.
Cancer cell 2004;5(5):405-6.
2004: Bennett Kaufman; Orit Scharf; Jeffrey Arbeit; Margaret Ashcroft; J Martin Brown; Richard K Bruick; J Donald Chapman; Sydney M Evans; Amato J Giaccia; Adrian L Harris; Eric Huang; Randall Johnson; William Kaelin; Cameron J Koch; Patrick Maxwell; James Mitchell; Len Neckers; Garth Powis; Joseph Rajendran; Gregg L Semenza; Jonathan Simons; Erik Storkebaum; Michael J Welch; Murray Whitelaw; Giovanni Melillo; S Percy Ivy
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Cancer research 2004;64(9):3350-6.
2004: Gregg L Semenza
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):1173-7; discussion 1170-2.
2004: Kenji Kasuno; Satoshi Takabuchi; Kazuhiko Fukuda; Shinae Kizaka-Kondoh; Junji Yodoi; Takehiko Adachi; Gregg L Semenza; Kiichi Hirota
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling.
The Journal of biological chemistry 2004;279(4):2550-8.
2004: Hua Zhong; Gregg L Semenza; Jonathan W Simons; Angelo M DeMarzo
Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis.
Cancer detection and prevention 2004;28(2):88-93.
2004: Larissa A Shimoda; Gregg L Semenza
Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension.
Methods in enzymology 2004;381():121-9.
2003: Brian D Kelly; Sean F Hackett; Kiichi Hirota; Yuji Oshima; Zheqing Cai; Shannon Berg-Dixon; Ashley Rowan; Zhijiang Yan; Peter A Campochiaro; Gregg L Semenza
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.
Circulation research 2003;93(11):1074-81.
2003: Gregg L Semenza
Targeting HIF-1 for cancer therapy.
Nature reviews. Cancer 2003;3(10):721-32.
2003: Oliver Stoeltzing; Wenbiao Liu; Niels Reinmuth; Fan Fan; Alexander A Parikh; Corazon D Bucana; Douglas B Evans; Gregg L Semenza; Lee M Ellis
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.
The American journal of pathology 2003;163(3):1001-11.
2003: Zheqing Cai; Dominador J Manalo; Guo Wei; E Rene Rodriguez; Karen Fox-Talbot; Huasheng Lu; Jay L Zweier; Gregg L Semenza
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.
Circulation 2003;108(1):79-85.
2003: Ryo Fukuda; Brian Kelly; Gregg L Semenza
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
Cancer research 2003;63(9):2330-4.
2003: Reinhard Bos; Petra van Der Groep; Astrid E Greijer; Avi Shvarts; Sybren Meijer; HERBERT PINEDO; Gregg L Semenza; Paulus van Diest; ELSKEN VAN DER WALL
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma.
Cancer 2003;97(6):1573-81.
2003: Balaji Krishnamachary; Shannon Berg-Dixon; Brian Kelly; Faton H Agani; David M. Feldser; Gloria C Ferreira; Narayan Iyer; Jessica LaRusch; Brian Pak; Panthea Taghavi; Gregg L Semenza
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.
Cancer research 2003;63(5):1138-43.
2003: Peter Büchler; Howard A Reber; Manuela Büchler; Shailesh Shrinkante; Markus W Büchler; Helmut Friess; Gregg L Semenza; Oscar J Hines
Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer.
Pancreas 2003;26(1):56-64.
2003: Gregg L Semenza
Angiogenesis in ischemic and neoplastic disorders.
Annual review of medicine 2003;54():17-28.
2002: Hilde L K Janssen; Karin Haustermans; Debbie Sprong; Gerard Blommestijn; Ingrid Hofland; Frank J P Hoebers; Elke Blijweert; James Raleigh; Gregg L Semenza; Mahesh Varia; Alfons J M Balm; Marie-Louise F Van Velthuysen; Pierre Delaere; Raf Sciot; Adrian C Begg
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
International journal of radiation oncology, biology, physics 2002;54(5):1537-49.
2002: Sonny O Ang; Hua Chen; Kiichi Hirota; Victor Roland Gordeuk; Jaroslav Jelinek; Yongli Guan; Enli Liu; Adelina I Sergueeva; Galina Y Miasnikova; David Mole; Patrick H Maxwell; David Wayne Stockton; Gregg L Semenza; Josef T Prchal
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.
Nature genetics 2002;32(4):614-21.
2002: Ryo Fukuda; Kiichi Hirota; Fan Fan; Young Do Jung; Lee M Ellis; Gregg L Semenza
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
The Journal of biological chemistry 2002;277(41):38205-11.
2002: Gregg L Semenza
Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11570-2.
2002: Gregg L Semenza
Signal transduction to hypoxia-inducible factor 1.
Biochemical pharmacology 2002;64(5-6):993-8.
2002: Caroline Treins; Sophie Giorgetti-Peraldi; Joseph Murdaca; Gregg L Semenza; Emmanuel Van Obberghen
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.
The Journal of biological chemistry 2002;277(31):27975-81.
2002: Colyn B Cargile; Denise Li-Meng Goh; Barbara K Goodman; Xiao-Ning Chen; Julie R Korenberg; Gregg L Semenza; George H Thomas
Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome.
American journal of medical genetics 2002;109(2):133-8.
2002: Hidefumi Kojima; Hua Gu; Saeko Nomura; Charles C Caldwell; Tetsuji Kobata; Peter Carmeliet; Gregg L Semenza; Michail V Sitkovsky
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2170-4.
2002: Gregg L Semenza
Involvement of hypoxia-inducible factor 1 in human cancer.
Internal medicine (Tokyo, Japan) 2002;41(2):79-83.
2002: David D Kline; Ying-Jie Peng; Dominador J Manalo; Gregg L Semenza; Nanduri R Prabhakar
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):821-6.
2002: Reinhard Bos; Jacobus J M van Der Hoeven; ELSKEN VAN DER WALL; Petra van Der Groep; Paulus van Diest; Emile F I Comans; Urvi Joshi; Gregg L Semenza; Otto S Hoekstra; Adriaan A Lammertsma; Carla F M Molthoff
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(2):379-87.
2002: Gregg L Semenza
HIF-1 and tumor progression: pathophysiology and therapeutics.
Trends in molecular medicine 2002;8(4 Suppl):S62-7.
2001: Takafumi Itoh; Tsunehisa Namba; Kazuhiko Fukuda; Gregg L Semenza; Kiichi Hirota
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.
FEBS letters 2001;509(2):225-9.
2001: Patrick C Mahon; K Hirota; Gregg L Semenza
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
Genes & development 2001;15(20):2675-86.
2001: Gregg L Semenza
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
Cell 2001;107(1):1-3.
2001: Rubin M Tuder; M Chacon; LA Alger; Jian Wang; Laimute Taraseviciene-Stewart; Yasunori Kasahara; Carlyne D Cool; A E Bishop; Mark W Geraci; Gregg L Semenza; M Yacoub; J M Polak; Norbert F Voelkel
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.
The Journal of pathology 2001;195(3):367-74.
2001: Gregg L Semenza
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.
Trends in molecular medicine 2001;7(8):345-50.
2001: Gregg L Semenza
Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance.
The Journal of clinical investigation 2001;108(1):39-40.
2001: Larissa A Shimoda; Dominador J Manalo; James Sham; Gregg L Semenza; JIM SYLVESTER
Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2001;281(1):L202-8.
2001: Kiichi Hirota; Gregg L Semenza
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
The Journal of biological chemistry 2001;276(24):21166-72.
2001: E Laughner; Panthea Taghavi; Kelly A Chiles; Patrick C Mahon; Gregg L Semenza
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.
Molecular and cellular biology 2001;21(12):3995-4004.
2001: Zheng Dong; Manjeri Venkatachalam; J Wang; Y Patel; Pothana Saikumar; Gregg L Semenza; T Force; Junichiro Nishiyama
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.
The Journal of biological chemistry 2001;276(22):18702-9.
2001: Gregg L Semenza
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease.
Pediatric research 2001;49(5):614-7.
2001: Daniel M Aebersold; Peter Burri; Karl T Beer; Jean A Laissue; Valentin Djonov; Richard H Greiner; Gregg L Semenza
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.
Cancer research 2001;61(7):2911-6.
2001: Gregg L Semenza
HIF-1 and mechanisms of hypoxia sensing.
Current opinion in cell biology 2001;13(2):167-71.
2001: Lawrence B Gardner; Q Li; M S Park; W M Flanagan; Gregg L Semenza; Chi Dang
Hypoxia inhibits G1/S transition through regulation of p27 expression.
The Journal of biological chemistry 2001;276(11):7919-26.
2001: R Bos; Hua Zhong; CF Hanrahan; EC Mommers; Gregg L Semenza; HERBERT PINEDO; M D Abeloff; J W Simons; Paulus van Diest; ELSKEN VAN DER WALL
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.
Journal of the National Cancer Institute 2001;93(4):309-14.
2001: Gregg L Semenza; Dmitri Artemov; Atul Bedi; Zaver M Bhujwalla; Kelly A Chiles; David M. Feldser; E Laughner; Rajani Ravi; J Simons; Panthea Taghavi; Hua Zhong
'The metabolism of tumours': 70 years later.
Novartis Foundation symposium 2001;240():251-60; discussion 260-4.
2000: Gregg L Semenza
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.
The Journal of clinical investigation 2000;106(7):809-12.
2000: Alain Rivard; L Berthou-Soulie; Nicole Principe; Marianne Kearney; C Curry; Didier Branellec; Gregg L Semenza; Jeffrey M Isner
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity.
The Journal of biological chemistry 2000;275(38):29643-7.
2000: M Bergeron; J M Gidday; A Y Yu; Gregg L Semenza; Donna M Ferriero; Frank R Sharp
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain.
Annals of neurology 2000;48(3):285-96.
2000: Gregg L Semenza
HIF-1 and human disease: one highly involved factor.
Genes & development 2000;14(16):1983-91.
2000: David Zagzag; David R Friedlander; Benjamin L Margolis; Martin Grumet; Gregg L Semenza; Hua Zhong; Jonathan W Simons; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: David Zagzag; Hua Zhong; Joanne Scalzitti; E Laughner; Jonathan W Simons; Gregg L Semenza
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.
Cancer 2000;88(11):2606-18.
2000: C H Sutter; E Laughner; Gregg L Semenza
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4748-53.
2000: Gregg L Semenza
HIF-1: mediator of physiological and pathophysiological responses to hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(4):1474-80.
2000: Hua Zhong; Kelly A Chiles; David M. Feldser; E Laughner; CF Hanrahan; M M Georgescu; Jonathan W Simons; Gregg L Semenza
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
Cancer research 2000;60(6):1541-5.
2000: Patrice M Becker; A Alcasabas; AY Yu; Gregg L Semenza; Tracie E Bunton
Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs.
American journal of respiratory cell and molecular biology 2000;22(3):272-9.
2000: Gregg L Semenza
Cellular and molecular dissection of reperfusion injury: ROS within and without.
Circulation research 2000;86(2):117-8.
2000: Gregg L Semenza
Oxygen-regulated transcription factors and their role in pulmonary disease.
Respiratory research 2000;1(3):159-62.
2000: Gregg L Semenza
HIF-1: using two hands to flip the angiogenic switch.
Cancer metastasis reviews 2000;19(1-2):59-65.
2000: Gregg L Semenza
Chairman's summary: mechanisms of oxygen homeostasis, circa 1999.
Advances in experimental medicine and biology 2000;475():303-10.
2000: Gregg L Semenza; Faton H Agani; David M. Feldser; Narayan Iyer; Lori E Kotch; E Laughner; A Yu
Hypoxia, HIF-1, and the pathophysiology of common human diseases.
Advances in experimental medicine and biology 2000;475():123-30.
2000: Gregg L Semenza
Hypoxia, clonal selection, and the role of HIF-1 in tumor progression.
Critical reviews in biochemistry and molecular biology 2000;35(2):71-103.
2000: Rajani Ravi; B Mookerjee; Zaver M Bhujwalla; C H Sutter; Dmitri Artemov; Q Zeng; Larry E Dillehay; A Madan; Gregg L Semenza; Atul Bedi
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
Genes & development 2000;14(1):34-44.
2000: Gregg L Semenza
Expression of hypoxia-inducible factor 1: mechanisms and consequences.
Biochemical pharmacology 2000;59(1):47-53.
1999: M Bergeron; A Y Yu; Karen Solway; Gregg L Semenza; Frank R Sharp
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain.
The European journal of neuroscience 1999;11(12):4159-70.
1999: Hua Zhong; Angelo M DeMarzo; E Laughner; M Lim; D A Hilton; David Zagzag; P Buechler; William B Isaacs; Gregg L Semenza; Jonathan W Simons
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Cancer research 1999;59(22):5830-5.
1999: Khalequz Zaman; Hoon Ryu; D Hall; KJ O'Donovan; KI Lin; M P Miller; J C Marquis; Jay M Baraban; Gregg L Semenza; Rajiv R Ratan
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9821-30.
1999: David M. Feldser; Faton H Agani; Narayan Iyer; B Pak; Gloria C Ferreira; Gregg L Semenza
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
Cancer research 1999;59(16):3915-8.
1999: Gregg L Semenza
Perspectives on oxygen sensing.
Cell 1999;98(3):281-4.
1999: A Yu; A Alcasabas; Gregg L Semenza; Patrice M Becker
Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia.
Chest 1999;116(1 Suppl):32S.
1999: Gregg L Semenza; Faton H Agani; Narayan Iyer; Lori E Kotch; E Laughner; S Leung; A Yu
Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.
Annals of the New York Academy of Sciences 1999;874():262-8.
1999: Lori E Kotch; Narayan Iyer; E Laughner; Gregg L Semenza
Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death.
Developmental biology 1999;209(2):254-67.
1999: AY Yu; Larissa A Shimoda; Narayan Iyer; David L Huso; X Sun; Rita McWilliams; Terri H beaty; James Sham; Charles M Wiener; JIM SYLVESTER; Gregg L Semenza
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha.
The Journal of clinical investigation 1999;103(5):691-6.
1999: Chi Dang; Gregg L Semenza
Oncogenic alterations of metabolism.
Trends in biochemical sciences 1999;24(2):68-72.
1999: Gregg L Semenza
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.
Annual review of cell and developmental biology 1999;15():551-78.
1999: H Ozaki; AY Yu; Neil G Della; K Ozaki; JD Luna; Haruhiko Yamada; Sean F Hackett; Naoyuki Okamoto; Donald J Zack; Gregg L Semenza; Peter A Campochiaro
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
Investigative ophthalmology & visual science 1999;40(1):182-9.
1998: Hua Zhong; Faton H Agani; AA Baccala; E Laughner; N Rioseco-Camacho; William B Isaacs; Jonathan W Simons; Gregg L Semenza
Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.
Cancer research 1998;58(23):5280-4.
1998: Faton H Agani; Gregg L Semenza
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Molecular pharmacology 1998;54(5):749-54.
1998: Gregg L Semenza
Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
Current opinion in genetics & development 1998;8(5):588-94.
1998: AY Yu; M G Frid; Larissa A Shimoda; Charles M Wiener; Kurt R Stenmark; Gregg L Semenza
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung.
The American journal of physiology 1998;275(4 Pt 1):L818-26.
1998: Narayan Iyer; Steve W Leung; Gregg L Semenza
The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation.
Genomics 1998;52(2):159-65.
1998: Gregg L Semenza; Faton H Agani; Narayan Iyer; Bing-Hua Jiang; S Leung; Charles M Wiener; A Yu
Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology.
Chest 1998;114(1 Suppl):40S-45S.
1998: Y Liu; Helen Christou; T Morita; E Laughner; Gregg L Semenza; Stella Kourembanas
Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer.
The Journal of biological chemistry 1998;273(24):15257-62.
1998: C Martin; AY Yu; Bing-Hua Jiang; Lowell E Davis; D Kimberly; Alan Roger (Roger) Hohimer; Gregg L Semenza
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1.
American journal of obstetrics and gynecology 1998;178(3):527-34.
1998: Gregg L Semenza
Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis.
The Journal of laboratory and clinical medicine 1998;131(3):207-14.
1998: Lisa A Palmer; Gregg L Semenza; M H Stoler; Roger Johns
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1.
The American journal of physiology 1998;274(2 Pt 1):L212-9.
1998: Narayan Iyer; Lori E Kotch; Faton H Agani; Steve W Leung; E Laughner; R H Wenger; M Gassmann; John D Gearhart; Ann M Lawler; AY Yu; Gregg L Semenza
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.
Genes & development 1998;12(2):149-62.
1997: Bing-Hua Jiang; Faton H Agani; Antonino Passaniti; Gregg L Semenza
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.
Cancer research 1997;57(23):5328-35.
1997: Faton H Agani; D G Kirsch; S L Friedman; Michael B Kastan; Gregg L Semenza
p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
Cancer research 1997;57(20):4474-7.
1997: Bing-Hua Jiang; Jenny Z Zheng; Steve W Leung; R Roe; Gregg L Semenza
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
The Journal of biological chemistry 1997;272(31):19253-60.
1997: Kimberly F Doheny; S A Rasmussen; Julie Rutberg; Gregg L Semenza; J Stamberg; M Schwartz; Denise A S Batista; Gail Stetten; George H Thomas
Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins.
American journal of medical genetics 1997;69(2):188-93.
1997: JM Winograd; M P Reilly; R Roe; J Lutz; E Laughner; X Xu; L Hu; T Asakura; Craig A Vander Kolk; JD Strandberg; Gregg L Semenza
Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.
Human molecular genetics 1997;6(3):369-79.
1997: Patty J Lee; Bing-Hua Jiang; Beek Yoke Chin; Narayan Iyer; Jawed Alam; Gregg L Semenza; Augustine M K Choi
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia.
The Journal of biological chemistry 1997;272(9):5375-81.
1997: Gregg L Semenza; Faton H Agani; GM Booth; J Forsythe; Narayan Iyer; Bing-Hua Jiang; S Leung; R Roe; Charles M Wiener; A Yu
Structural and functional analysis of hypoxia-inducible factor 1.
Kidney international 1997;51(2):553-5.
1996: Gregg L Semenza; Bing-Hua Jiang; Steve W Leung; R Passantino; J P Concordet; Pascal Maire; Agata Giallongo
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
The Journal of biological chemistry 1996;271(51):32529-37.
1996: Bing-Hua Jiang; Gregg L Semenza; C Bauer; Hugo H Marti
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
The American journal of physiology 1996;271(4 Pt 1):C1172-80.
1996: J A Forsythe; Bing-Hua Jiang; Narayan Iyer; Faton H Agani; Steve W Leung; Robert D Koos; Gregg L Semenza
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Molecular and cellular biology 1996;16(9):4604-13.
1996: Charles M Wiener; G Booth; Gregg L Semenza
In vivo expression of mRNAs encoding hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1996;225(2):485-8.
1996: Bing-Hua Jiang; E Rue; G L Wang; R Roe; Gregg L Semenza
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.
The Journal of biological chemistry 1996;271(30):17771-8.
1996: Gregg L Semenza
Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis.
Trends in cardiovascular medicine 1996;6(5):151-7.
1996: Gregg L Semenza; E A Rue; Narayan Iyer; M G Pang; William G Kearns
Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q.
Genomics 1996;34(3):437-9.
1996: G L Wang; Gregg L Semenza
Molecular basis of hypoxia-induced erythropoietin expression.
Current opinion in hematology 1996;3(2):156-62.
1995: G L Wang; Bing-Hua Jiang; Gregg L Semenza
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1995;216(2):669-75.
1995: G L Wang; Bing-Hua Jiang; Gregg L Semenza
Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1995;212(2):550-6.
1995: L Sokol; M Luhovy; Y Guan; JF Prchal; Gregg L Semenza; Josef T Prchal
Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin.
Blood 1995;86(1):15-22.
1995: Josef T Prchal; Gregg L Semenza; J Prchal; L Sokol
Familial polycythemia.
Science (New York, N.Y.) 1995;268(5219):1831-2.
1995: G L Wang; Bing-Hua Jiang; E A Rue; Gregg L Semenza
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5510-4.
1995: Gregg L Semenza; G L Wang; R Kundu
DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2.
Biochemical and biophysical research communications 1995;209(1):257-62.
1995: G L Wang; Gregg L Semenza
Purification and characterization of hypoxia-inducible factor 1.
The Journal of biological chemistry 1995;270(3):1230-7.
1994: Gregg L Semenza
Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis.
Hematology/oncology clinics of North America 1994;8(5):863-84.
1994: Gregg L Semenza; P H Roth; H M Fang; G L Wang
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
The Journal of biological chemistry 1994;269(38):23757-63.
1994: Gregg L Semenza
Erythropoietin gene expression in transgenic mice and human hepatoma cells.
Annals of the New York Academy of Sciences 1994;718():41-7; discussion 47-9.
1994: Gregg L Semenza
Transcriptional regulation of gene expression: mechanisms and pathophysiology.
Human mutation 1994;3(3):180-99.
1993: G L Wang; Gregg L Semenza
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Blood 1993;82(12):3610-5.
1993: G L Wang; Gregg L Semenza
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
The Journal of biological chemistry 1993;268(29):21513-8.
1993: G L Wang; Gregg L Semenza
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4304-8.
1993: Stephen Thomas Koury; M C Bondurant; Gregg L Semenza; Mark J Koury
The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver.
Microscopy research and technique 1993;25(1):29-39.
1992: Gregg L Semenza; G L Wang
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Molecular and cellular biology 1992;12(12):5447-54.
1991: Gregg L Semenza; Stephen Thomas Koury; M K Nejfelt; John D Gearhart; S E Antonarakis
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8725-9.
1991: Gregg L Semenza; M K Nejfelt; S M Chi; S E Antonarakis
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5680-4.
1991: M C Bondurant; Mark J Koury; Stephen Thomas Koury; Gregg L Semenza
Erythropoietin ontogeny and organ distribution in mice.
Seminars in hematology 1991;28(3 Suppl 3):20-5; discussion 26-7.
1991: Stephen Thomas Koury; M C Bondurant; Mark J Koury; Gregg L Semenza
Localization of cells producing erythropoietin in murine liver by in situ hybridization.
Blood 1991;77(11):2497-503.
1990: Gregg L Semenza; R C Dureza; M D Traystman; John D Gearhart; S E Antonarakis
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.
Molecular and cellular biology 1990;10(3):930-8.
1989: Gregg L Semenza; M D Traystman; John D Gearhart; S E Antonarakis
Polycythemia in transgenic mice expressing the human erythropoietin gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2301-5.
1989: Gregg L Semenza; C E Dowling; Haig Kazazian
Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR).
Nucleic acids research 1989;17(6):2376.
1988: Gregg L Semenza; R E Pyeritz
Respiratory complications of mucopolysaccharide storage disorders.
Medicine 1988;67(4):209-19.
1987: Gregg L Semenza; John A A Ladias; S E Antonarakis
An Xba I polymorphism 3' to the human erythropoietin (EPO) gene.
Nucleic acids research 1987;15(16):6768.
1984: Gregg L Semenza; K Delgrosso; Mortimer Poncz; P Malladi; E Schwartz; Saul Surrey
The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions.
Cell 1984;39(1):123-8.
1984: Gregg L Semenza; P Malladi; Saul Surrey; K Delgrosso; Mortimer Poncz; E Schwartz
Detection of a novel DNA polymorphism in the beta-globin gene cluster.
The Journal of biological chemistry 1984;259(10):6045-8.