Gregg Semenza

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Disorders

Physiology

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Sarkar Kakali; Fox-Talbot Karen; Steenbergen Charles; Bosch-Marcé Marta; Semenza Gregg L
Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.
Xia Menghang; Huang Ruili; Sun Yi; Semenza Gregg L; Aldred Shelley Force; Witt Kristine L; Inglese James; Tice Raymond R; Austin Christopher P
Identification of chemical compounds that induce HIF-1alpha activity.
Semenza Gregg L
Regulation of vascularization by hypoxia-inducible factor 1.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Gregg Semenza (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Sarkar Kakali; Fox-Talbot Karen; Steenbergen Charles; Bosch-Marcé Marta; Semenza Gregg L
Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18769-74.
2009: Xia Menghang; Huang Ruili; Sun Yi; Semenza Gregg L; Aldred Shelley Force; Witt Kristine L; Inglese James; Tice Raymond R; Austin Christopher P
Identification of chemical compounds that induce HIF-1alpha activity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):153-63.
2009: Semenza Gregg L
Regulation of vascularization by hypoxia-inducible factor 1.
Annals of the New York Academy of Sciences 2009;1177():2-8.
2009: Lee KangAe; Zhang Huafeng; Qian David Z; Rey Sergio; Liu Jun O; Semenza Gregg L
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17910-5.
2009: Wikenheiser Jamie; Wolfram Julie A; Gargesha Madhusudhana; Yang Ke; Karunamuni Ganga; Wilson David L; Semenza Gregg L; Agani Faton; Fisher Steven A; Ward Nicole; Watanabe Michiko
Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(10):2688-700.
2009: Semenza Gregg L
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
Blood 2009;114(10):2015-9.
2009: Schipani Ernestina; Maes Christa; Carmeliet Geert; Semenza Gregg L
Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(8):1347-53.
2009: Siddiq Ambreena; Aminova Leila R; Troy Carol M; Suh Kyungsun; Messer Zachary; Semenza Gregg L; Ratan Rajiv R
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(27):8828-38.
2009: Semenza Gregg
Recent advances in vascular biology and their clinical relevance.
Journal of molecular medicine (Berlin, Germany) 2009;87(6):547-8.
2009: Kizaka-Kondoh Shinae; Itasaka Satoshi; Zeng Lihua; Tanaka Shotaro; Zhao Tao; Takahashi Yumi; Shibuya Keiko; Hirota Kiichi; Semenza Gregg L; Hiraoka Masahiro
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3433-41.
2009: Semenza Gregg L
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Physiology (Bethesda, Md.) 2009;24():97-106.
2009: Lee KangAe; Qian David Z; Rey Sergio; Wei Hong; Liu Jun O; Semenza Gregg L
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2353-8.
2009: Semenza Gregg L
Regulation of cancer cell metabolism by hypoxia-inducible factor 1.
Seminars in cancer biology 2009;19(1):12-6.
2009: Ganten Detlev; Semenza Gregg L; Nolte Christiane
Fostering trust-- Mol Med's scientific integrity policy.
Journal of molecular medicine (Berlin, Germany) 2009;87(1):1-2.
2009: Guo Jia; Lu Wenju; Shimoda Larissa A; Semenza Gregg L; Georas Steve N
Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice.
International archives of allergy and immunology 2009;149(2):98-102.
2008: Semenza Gregg L
Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(24):7969-70.
2008: Ratan Rajiv R; Siddiq Ambreena; Aminova Leila; Langley Brett; McConoughey Stephen; Karpisheva Ksenia; Lee Hsin-Hwa; Carmichael Thomas; Kornblum Harley; Coppola Giovanni; Geschwind Daniel H; Hoke Ahmet; Smirnova Natalya; Rink Cameron; Roy Sashwati; Sen Chandan; Beattie Michael S; Hart Ron P; Grumet Martin; Sun Dongming; Freeman Robert S; Semenza Gregg L; Gazaryan Irina
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Annals of the New York Academy of Sciences 2008;1147():383-94.
2008: Semenza Gregg L
Tumor metabolism: cancer cells give and take lactate.
The Journal of clinical investigation 2008;118(12):3835-7.
2008: Zhang Huafeng; Qian David Z; Tan Yee Sun; Lee Kangae; Gao Ping; Ren Yunzhao R; Rey Sergio; Hammers Hans; Chang Daniel; Pili Roberto; Dang Chi V; Liu Jun O; Semenza Gregg L
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(50):19579-86.
2008: Nanduri Jayasri; Yuan Guoxiang; Kumar Ganesh K; Semenza Gregg L; Prabhakar Nanduri R
Transcriptional responses to intermittent hypoxia.
Respiratory physiology & neurobiology 2008;164(1-2):277-81.
2008: Yuan Guoxiang; Nanduri Jayasri; Khan Shakil; Semenza Gregg L; Prabhakar Nanduri R
Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
Journal of cellular physiology 2008;217(3):674-85.
2008: Liu Lixin; Marti Guy P; Wei Xiaofei; Zhang Xianjie; Zhang Huafeng; Liu Ye V; Nastai Manuel; Semenza Gregg L; Harmon John W
Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells.
Journal of cellular physiology 2008;217(2):319-27.
2008: Semenza Gregg L
Hypoxia-inducible factor 1 and cancer pathogenesis.
IUBMB life 2008;60(9):591-7.
2008: Sullivan Richard; Paré Geneviève C; Frederiksen Lisa J; Semenza Gregg L; Graham Charles H
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity.
Molecular cancer therapeutics 2008;7(7):1961-73.
2008: Zhang Huafeng; Semenza Gregg L
The expanding universe of hypoxia.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):739-46.
2008: Semenza Gregg L
A new weapon for attacking tumor blood vessels.
The New England journal of medicine 2008;358(19):2066-7.
2008: Semenza Gregg L
Mitochondrial autophagy: life and breath of the cell.
Autophagy 2008;4(4):534-6.
2008: Nishi Kenichiro; Oda Tomoyuki; Takabuchi Satoshi; Oda Seiko; Fukuda Kazuhiko; Adachi Takehiko; Semenza Gregg L; Shingu Koh; Hirota Kiichi
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner.
Antioxidants & redox signaling 2008;10(5):983-95.
2008: Semenza Gregg L
O2 sensing: only skin deep?
Cell 2008;133(2):206-8.
2008: Zhang Huafeng; Bosch-Marce Marta; Shimoda Larissa A; Tan Yee Sun; Baek Jin Hyen; Wesley Jacob B; Gonzalez Frank J; Semenza Gregg L
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
The Journal of biological chemistry 2008;283(16):10892-903.
2008: Kimura Motohide; Takabuchi Satoshi; Tanaka Tomoharu; Murata Miyahiko; Nishi Kenichiro; Oda Seiko; Oda Tomoyuki; Kanai Michiyuki; Fukuda Kazuhiko; Kizaka-Kondoh Shinae; Adachi Takehiko; Takabayashi Arimichi; Semenza Gregg L; Hirota Kiichi
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems.
The Biochemical journal 2008;411(1):97-105.
2008: Whitman E Miles; Pisarcik Sarah; Luke Trevor; Fallon Michele; Wang Jian; Sylvester J T; Semenza Gregg L; Shimoda Larissa A
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes.
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L309-18.
2008: Cai Zheqing; Zhong Hua; Bosch-Marce Marta; Fox-Talbot Karen; Wang Lei; Wei Chiming; Trush Michael A; Semenza Gregg L
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha.
Cardiovascular research 2008;77(3):463-70.
2008: Tan M; Gu Q; He H; Pamarthy D; Semenza G L; Sun Y
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation.
Oncogene 2008;27(10):1404-11.
2008: Oda Seiko; Oda Tomoyuki; Nishi Kenichiro; Takabuchi Satoshi; Wakamatsu Takuhiko; Tanaka Tomoharu; Adachi Takehiko; Fukuda Kazuhiko; Semenza Gregg L; Hirota Kiichi
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner.
PloS one 2008;3(5):e2215.
2007: Semenza G L
Hypoxia and human disease-and the Journal of Molecular Medicine.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1293-4.
2007: Liu Ye V; Hubbi Maimon E; Pan Fan; McDonald Karin R; Mansharamani Malini; Cole Robert N; Liu Jun O; Semenza Gregg L
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
The Journal of biological chemistry 2007;282(51):37064-73.
2007: Bosch-Marce Marta; Okuyama Hiroaki; Wesley Jacob B; Sarkar Kakali; Kimura Hideo; Liu Ye V; Zhang Huafeng; Strazza Marianne; Rey Sergio; Savino Lindsey; Zhou Yi Fu; McDonald Karin R; Na Youn; Vandiver Scott; Rabi Alireza; Shaked Yuval; Kerbel Robert; Lavallee Theresa; Semenza Gregg L
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia.
Circulation research 2007;101(12):1310-8.
2007: Semenza Gregg L
Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling.
Journal of cellular biochemistry 2007;102(4):840-7.
2007: Baek Jin H; Liu Ye V; McDonald Karin R; Wesley Jacob B; Zhang Huafeng; Semenza Gregg L
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
The Journal of biological chemistry 2007;282(46):33358-66.
2007: Kim Jung-whan; Gao Ping; Liu Yen-Chun; Semenza Gregg L; Dang Chi V
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.
Molecular and cellular biology 2007;27(21):7381-93.
2007: Semenza Gregg L
Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.
Experimental physiology 2007;92(6):988-91.
2007: Semenza Gregg L
Evaluation of HIF-1 inhibitors as anticancer agents.
Drug discovery today 2007;12(19-20):853-9.
2007: Semenza Gregg L
Hypoxia-inducible factor 1 (HIF-1) pathway.
Science's STKE : signal transduction knowledge environment 2007;2007(407):cm8.
2007: Semenza Gregg L
Life with oxygen.
Science (New York, N.Y.) 2007;318(5847):62-4.
2007: Gao Ping; Zhang Huafeng; Dinavahi Ramani; Li Feng; Xiang Yan; Raman Venu; Bhujwalla Zaver M; Felsher Dean W; Cheng Linzhao; Pevsner Jonathan; Lee Linda A; Semenza Gregg L; Dang Chi V
HIF-dependent antitumorigenic effect of antioxidants in vivo.
Cancer cell 2007;12(3):230-8.
2007: Semenza Gregg L; Prabhakar Nanduri R
HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia.
Antioxidants & redox signaling 2007;9(9):1391-6.
2007: Prabhakar Nanduri R; Kumar Ganesh K; Nanduri Jayasri; Semenza Gregg L
ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.
Antioxidants & redox signaling 2007;9(9):1397-403.
2007: Tomita Mariko; Semenza Gregg L; Michiels Canine; Matsuda Takehiro; Uchihara Jun-Nosuke; Okudaira Taeko; Tanaka Yuetsu; Taira Naoya; Ohshiro Kazuiku; Mori Naoki
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells.
The Biochemical journal 2007;406(2):317-23.
2007: Baek Jin Hyen; Liu Ye V; McDonald Karin R; Wesley Jacob B; Hubbi Maimon E; Byun Hweejo; Semenza Gregg L
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
The Journal of biological chemistry 2007;282(32):23572-80.
2007: Semenza Gregg L
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.
The Biochemical journal 2007;405(1):1-9.
2007: Semenza Gregg L
HIF-1 mediates the Warburg effect in clear cell renal carcinoma.
Journal of bioenergetics and biomembranes 2007;39(3):231-4.
2007: Semenza Gregg L
Hypoxia and cancer.
Cancer metastasis reviews 2007;26(2):223-4.
2007: Zhang Huafeng; Gao Ping; Fukuda Ryo; Kumar Ganesh; Krishnamachary Balaji; Zeller Karen I; Dang Chi V; Semenza Gregg L
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Cancer cell 2007;11(5):407-20.
2007: Fukuda Ryo; Zhang Huafeng; Kim Jung-whan; Shimoda Larissa; Dang Chi V; Semenza Gregg L
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
Cell 2007;129(1):111-22.
2007: Liu Ye V; Semenza Gregg L
RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
Cell cycle (Georgetown, Tex.) 2007;6(6):656-9.
2007: Komatsu David E; Bosch-Marce Marta; Semenza Gregg L; Hadjiargyrou Michael
Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(3):366-74.
2007: Liu Ye V; Baek Jin H; Zhang Huafeng; Diez Roberto; Cole Robert N; Semenza Gregg L
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.
Molecular cell 2007;25(2):207-17.
2007: Xu Bing; Doughman Yongqiu; Turakhia Mona; Jiang Weihong; Landsettle Chad E; Agani Faton H; Semenza Gregg L; Watanabe Michiko; Yang Yu-Chung
Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity.
Developmental biology 2007;301(1):130-40.
2007: Krishnamachary Balaji; Semenza Gregg L
Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis.
Methods in enzymology 2007;435():347-54.
2006: Semenza Gregg L
Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression.
Molecular pharmacology 2006;70(6):1841-3.
2006: Peng Ying-Jie; Yuan Guoxiang; Ramakrishnan Deviprasadh; Sharma Suresh D; Bosch-Marce Marta; Kumar Ganesh K; Semenza Gregg L; Prabhakar Nanduri R
Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.
The Journal of physiology 2006;577(Pt 2):705-16.
2006: Zhou Yi Fu; Bosch-Marce Marta; Okuyama Hiroaki; Krishnamachary Balaji; Kimura Hideo; Zhang Li; Huso David L; Semenza Gregg L
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells.
Cancer research 2006;66(22):10849-54.
2006: Cai Zheqing; Semenza Gregg L
Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus?
Circulation research 2006;99(10):e86.
2006: Shimoda Larissa A; Fallon Michele; Pisarcik Sarah; Wang Jian; Semenza Gregg L
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L941-9.
2006: Tatum James L; Kelloff Gary J; Gillies Robert J; Arbeit Jeffrey M; Brown J Martin; Chao K S Clifford; Chapman J Donald; Eckelman William C; Fyles Anthony W; Giaccia Amato J; Hill Richard P; Koch Cameron J; Krishna Murali Cherukuri; Krohn Kenneth A; Lewis Jason S; Mason Ralph P; Melillo Giovanni; Padhani Anwar R; Powis Garth; Rajendran Joseph G; Reba Richard; Robinson Simon P; Semenza Gregg L; Swartz Harold M; Vaupel Peter; Yang David; Croft Barbara; Hoffman John; Liu Guoying; Stone Helen; Sullivan Daniel
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.
International journal of radiation biology 2006;82(10):699-757.
2006: Semenza Gregg L
Hypoxia pathway linked to kidney failure.
Nature medicine 2006;12(9):996-7.
2006: Yoon Donghoon; Pastore Yves D; Divoky Vladimir; Liu Enli; Mlodnicka Agnieszka E; Rainey Karin; Ponka Premysl; Semenza Gregg L; Schumacher Armin; Prchal Josef T
Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.
The Journal of biological chemistry 2006;281(35):25703-11.
2006: Semenza Gregg L
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.
Experimental physiology 2006;91(5):803-6.
2006: Hirota Kiichi; Semenza Gregg L
Regulation of angiogenesis by hypoxia-inducible factor 1.
Critical reviews in oncology/hematology 2006;59(1):15-26.
2006: Oda Tomoyuki; Hirota Kiichi; Nishi Kenichiro; Takabuchi Satoshi; Oda Seiko; Yamada Hiroko; Arai Toshiyuki; Fukuda Kazuhiko; Kita Toru; Adachi Takehiko; Semenza Gregg L; Nohara Ryuji
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
American journal of physiology. Cell physiology 2006;291(1):C104-13.
2006: Lahiri S; Roy A; Baby S M; Hoshi T; Semenza G L; Prabhakar N R
Oxygen sensing in the body.
Progress in biophysics and molecular biology 2006;91(3):249-86.
2006: Wang Jian; Weigand Letitia; Lu Wenju; Sylvester J T; Semenza Gregg L; Shimoda Larissa A
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells.
Circulation research 2006;98(12):1528-37.
2006: Okuyama Hiroaki; Krishnamachary Balaji; Zhou Yi Fu; Nagasawa Hideko; Bosch-Marce Marta; Semenza Gregg L
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
The Journal of biological chemistry 2006;281(22):15554-63.
2006: Semenza Gregg L
VHL and p53: tumor suppressors team up to prevent cancer.
Molecular cell 2006;22(4):437-9.
2006: Semenza Gregg L
Therapeutic angiogenesis: another passing phase?
Circulation research 2006;98(9):1115-6.
2006: Melillo Giovanni; Semenza Gregg L
Meeting report: exploiting the tumor microenvironment for therapeutics.
Cancer research 2006;66(9):4558-60.
2006: Li Jianguo; Bosch-Marce Marta; Nanayakkara Ashika; Savransky Vladimir; Fried Susan K; Semenza Gregg L; Polotsky Vsevolod Y
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Physiological genomics 2006;25(3):450-7.
2006: Semenza Gregg L
Development of novel therapeutic strategies that target HIF-1.
Expert opinion on therapeutic targets 2006;10(2):267-80.
2006: Kim Jung-whan; Tchernyshyov Irina; Semenza Gregg L; Dang Chi V
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
Cell metabolism 2006;3(3):177-85.
2006: Krishnamachary Balaji; Zagzag David; Nagasawa Hideko; Rainey Karin; Okuyama Hiroaki; Baek Jin H; Semenza Gregg L
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Cancer research 2006;66(5):2725-31.
2006: Semenza Gregg L; Shimoda Larissa A; Prabhakar Nanduri R
Regulation of gene expression by HIF-1.
Novartis Foundation symposium 2006;272():2-8; discussion 8-14, 33-6.
2005: Semenza Gregg L
Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology.
Chest 2005;128(6 Suppl):592S-594S.
2005: Cai Zheqing; Semenza Gregg L
PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning.
Circulation research 2005;97(12):1351-9.
2005: Hirota Kiichi; Semenza Gregg L
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.
Biochemical and biophysical research communications 2005;338(1):610-6.
2005: Semenza Gregg L
New insights into nNOS regulation of vascular homeostasis.
The Journal of clinical investigation 2005;115(11):2976-8.
2005: Patel Tarak H; Kimura Hideo; Weiss Clifford R; Semenza Gregg L; Hofmann Lawrence V
Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia.
Cardiovascular research 2005;68(1):144-54.
2005: Maloyan Alina; Eli-Berchoer Luba; Semenza Gregg L; Gerstenblith Gary; Stern Michael D; Horowitz Michal
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart.
Physiological genomics 2005;23(1):79-88.
2005: Resar Jon R; Roguin Ariel; Voner Jeffery; Nasir Khurram; Hennebry Thomas A; Miller Julie M; Ingersoll Roxann; Kasch Laura M; Semenza Gregg L
Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease.
Chest 2005;128(2):787-91.
2005: Xu Qing; Briggs Jon; Park Sungman; Niu Guilian; Kortylewski Marcin; Zhang Shumin; Gritsko Tanya; Turkson James; Kay Heidi; Semenza Gregg L; Cheng Jin Q; Jove Richard; Yu Hua
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
Oncogene 2005;24(36):5552-60.
2005: Zagzag David; Krishnamachary Balaji; Yee Herman; Okuyama Hiroaki; Chiriboga Luis; Ali M Aktar; Melamed Jonathan; Semenza Gregg L
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Cancer research 2005;65(14):6178-88.
2005: Greijer A E; van der Groep P; Kemming D; Shvarts A; Semenza G L; Meijer G A; van de Wiel M A; Belien J A M; van Diest P J; van der Wall E
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).
The Journal of pathology 2005;206(3):291-304.
2005: Gray Michael J; Zhang Jing; Ellis Lee M; Semenza Gregg L; Evans Douglas B; Watowich Stephanie S; Gallick Gary E
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Oncogene 2005;24(19):3110-20.
2005: Baek Jin Hyen; Mahon Patrick C; Oh Jane; Kelly Brian; Krishnamachary Balaji; Pearson Mia; Chan Denise A; Giaccia Amato J; Semenza Gregg L
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Molecular cell 2005;17(4):503-12.
2005: Yuan Guoxiang; Nanduri Jayasri; Bhasker C Raman; Semenza Gregg L; Prabhakar Nanduri R
Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
The Journal of biological chemistry 2005;280(6):4321-8.
2005: Manalo Dominador J; Rowan Ashley; Lavoie Tera; Natarajan Lakshmi; Kelly Brian D; Ye Shui Q; Garcia Joe G N; Semenza Gregg L
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.
Blood 2005;105(2):659-69.
2005: Semenza Gregg L
Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1.
Proceedings of the American Thoracic Society 2005;2(1):68-70.
2004: Takabuchi Satoshi; Hirota Kiichi; Nishi Kenichiro; Oda Seiko; Oda Tomoyuki; Shingu Koh; Takabayashi Arimichi; Adachi Takehiko; Semenza Gregg L; Fukuda Kazuhiko
The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner.
FEBS letters 2004;577(3):434-8.
2004: Takabuchi Satoshi; Hirota Kiichi; Nishi Kenichiro; Oda Seiko; Oda Tomoyuki; Shingu Koh; Takabayashi Arimichi; Adachi Takehiko; Semenza Gregg L; Fukuda Kazuhiko
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway.
Biochemical and biophysical research communications 2004;324(1):417-23.
2004: Hirota Kiichi; Fukuda Ryo; Takabuchi Satoshi; Kizaka-Kondoh Shinae; Adachi Takehiko; Fukuda Kazuhiko; Semenza Gregg L
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.
The Journal of biological chemistry 2004;279(40):41521-8.
2004: Semenza Gregg L
Hydroxylation of HIF-1: oxygen sensing at the molecular level.
Physiology (Bethesda, Md.) 2004;19():176-82.
2004: Stoeltzing Oliver; McCarty Marya F; Wey Jane S; Fan Fan; Liu Wenbiao; Belcheva Anna; Bucana Corazon D; Semenza Gregg L; Ellis Lee M
Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.
Journal of the National Cancer Institute 2004;96(12):946-56.
2004: Semenza Gregg L
Intratumoral hypoxia, radiation resistance, and HIF-1.
Cancer cell 2004;5(5):405-6.
2004: Kaufman Bennett; Scharf Orit; Arbeit Jeffrey; Ashcroft Margaret; Brown J Martin; Bruick Richard K; Chapman J Donald; Evans Sydney M; Giaccia Amato J; Harris Adrian L; Huang Eric; Johnson Randall; Kaelin William; Koch Cameron J; Maxwell Patrick; Mitchell James; Neckers Len; Powis Garth; Rajendran Joseph; Semenza Gregg L; Simons Jonathan; Storkebaum Erik; Welch Michael J; Whitelaw Murray; Melillo Giovanni; Ivy S Percy
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Cancer research 2004;64(9):3350-6.
2004: Cai Zheqing; Semenza Gregg L
Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury.
Circulation 2004;109(17):2050-3.
2004: Semenza Gregg L
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):1173-7; discussion 1170-2.
2004: Kasuno Kenji; Takabuchi Satoshi; Fukuda Kazuhiko; Kizaka-Kondoh Shinae; Yodoi Junji; Adachi Takehiko; Semenza Gregg L; Hirota Kiichi
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling.
The Journal of biological chemistry 2004;279(4):2550-8.
2004: Zhong Hua; Semenza Gregg L; Simons Jonathan W; De Marzo Angelo M
Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis.
Cancer detection and prevention 2004;28(2):88-93.
2004: Shimoda Larissa A; Semenza Gregg L
Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension.
Methods in enzymology 2004;381():121-9.
2003: Kelly Brian D; Hackett Sean F; Hirota Kiichi; Oshima Yuji; Cai Zheqing; Berg-Dixon Shannon; Rowan Ashley; Yan Zhijiang; Campochiaro Peter A; Semenza Gregg L
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.
Circulation research 2003;93(11):1074-81.
2003: Semenza Gregg L
Targeting HIF-1 for cancer therapy.
Nature reviews. Cancer 2003;3(10):721-32.
2003: Stoeltzing Oliver; Liu Wenbiao; Reinmuth Niels; Fan Fan; Parikh Alexander A; Bucana Corazon D; Evans Douglas B; Semenza Gregg L; Ellis Lee M
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.
The American journal of pathology 2003;163(3):1001-11.
2003: Cai Zheqing; Manalo Dominador J; Wei Guo; Rodriguez E Rene; Fox-Talbot Karen; Lu Huasheng; Zweier Jay L; Semenza Gregg L
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.
Circulation 2003;108(1):79-85.
2003: Fukuda Ryo; Kelly Brian; Semenza Gregg L
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
Cancer research 2003;63(9):2330-4.
2003: Bos Reinhard; van der Groep Petra; Greijer Astrid E; Shvarts Avi; Meijer Sybren; Pinedo Herbert M; Semenza Gregg L; van Diest Paul J; van der Wall Elsken
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma.
Cancer 2003;97(6):1573-81.
2003: Krishnamachary Balaji; Berg-Dixon Shannon; Kelly Brian; Agani Faton; Feldser David; Ferreira Gloria; Iyer Narayan; LaRusch Jessica; Pak Brian; Taghavi Panthea; Semenza Gregg L
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.
Cancer research 2003;63(5):1138-43.
2003: Büchler Peter; Reber Howard A; Büchler Manuela; Shrinkante Shailesh; Büchler Markus W; Friess Helmut; Semenza Gregg L; Hines Oscar J
Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer.
Pancreas 2003;26(1):56-64.
2003: Semenza Gregg L
Angiogenesis in ischemic and neoplastic disorders.
Annual review of medicine 2003;54():17-28.
2002: Janssen Hilde L K; Haustermans Karin M G; Sprong Debbie; Blommestijn Gerard; Hofland Ingrid; Hoebers Frank J; Blijweert Elke; Raleigh James A; Semenza Gregg L; Varia Mahesh A; Balm Alfons J; van Velthuysen Marie Louise F; Delaere Pierre; Sciot Raf; Begg Adrian C
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
International journal of radiation oncology, biology, physics 2002;54(5):1537-49.
2002: Ang Sonny O; Chen Hua; Hirota Kiichi; Gordeuk Victor R; Jelinek Jaroslav; Guan Yongli; Liu Enli; Sergueeva Adelina I; Miasnikova Galina Y; Mole David; Maxwell Patrick H; Stockton David W; Semenza Gregg L; Prchal Josef T
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.
Nature genetics 2002;32(4):614-21.
2002: Fukuda Ryo; Hirota Kiichi; Fan Fan; Jung Young Do; Ellis Lee M; Semenza Gregg L
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
The Journal of biological chemistry 2002;277(41):38205-11.
2002: Semenza Gregg
Signal transduction to hypoxia-inducible factor 1.
Biochemical pharmacology 2002;64(5-6):993-8.
2002: Semenza Gregg L
Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11570-2.
2002: Treins Caroline; Giorgetti-Peraldi Sophie; Murdaca Joseph; Semenza Gregg L; Van Obberghen Emmanuel
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.
The Journal of biological chemistry 2002;277(31):27975-81.
2002: Cargile Colyn B; Goh Denise L-M; Goodman Barbara K; Chen Xiao-Ning; Korenberg Julie R; Semenza Gregg L; Thomas George H
Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome.
American journal of medical genetics 2002;109(2):133-8.
2002: Semenza Gregg L
Involvement of hypoxia-inducible factor 1 in human cancer.
Internal medicine (Tokyo, Japan) 2002;41(2):79-83.
2002: Kojima Hidefumi; Gu Hua; Nomura Saeko; Caldwell Charles C; Kobata Tetsuji; Carmeliet Peter; Semenza Gregg L; Sitkovsky Michail V
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2170-4.
2002: Kline David D; Peng Ying-Jie; Manalo Dominador J; Semenza Gregg L; Prabhakar Nanduri R
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):821-6.
2002: Bos Reinhard; van Der Hoeven Jacobus J M; van Der Wall Elsken; van Der Groep Petra; van Diest Paul J; Comans Emile F I; Joshi Urvi; Semenza Gregg L; Hoekstra Otto S; Lammertsma Adriaan A; Molthoff Carla F M
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(2):379-87.
2002: Semenza Gregg L
HIF-1 and tumor progression: pathophysiology and therapeutics.
Trends in molecular medicine 2002;8(4 Suppl):S62-7.
2001: Itoh T; Namba T; Fukuda K; Semenza G L; Hirota K
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.
FEBS letters 2001;509(2):225-9.
2001: Tuder R M; Chacon M; Alger L; Wang J; Taraseviciene-Stewart L; Kasahara Y; Cool C D; Bishop A E; Geraci M; Semenza G L; Yacoub M; Polak J M; Voelkel N F
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.
The Journal of pathology 2001;195(3):367-74.
2001: Mahon P C; Hirota K; Semenza G L
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
Genes & development 2001;15(20):2675-86.
2001: Semenza G L
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
Cell 2001;107(1):1-3.
2001: Semenza G L
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.
Trends in molecular medicine 2001;7(8):345-50.
2001: Semenza G L
Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance.
The Journal of clinical investigation 2001;108(1):39-40.
2001: Shimoda L A; Manalo D J; Sham J S; Semenza G L; Sylvester J T
Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2001;281(1):L202-8.
2001: Laughner E; Taghavi P; Chiles K; Mahon P C; Semenza G L
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.
Molecular and cellular biology 2001;21(12):3995-4004.
2001: Hirota K; Semenza G L
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
The Journal of biological chemistry 2001;276(24):21166-72.
2001: Dong Z; Venkatachalam M A; Wang J; Patel Y; Saikumar P; Semenza G L; Force T; Nishiyama J
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.
The Journal of biological chemistry 2001;276(22):18702-9.
2001: Semenza G L
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease.
Pediatric research 2001;49(5):614-7.
2001: Aebersold D M; Burri P; Beer K T; Laissue J; Djonov V; Greiner R H; Semenza G L
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.
Cancer research 2001;61(7):2911-6.
2001: Semenza G L
HIF-1 and mechanisms of hypoxia sensing.
Current opinion in cell biology 2001;13(2):167-71.
2001: Gardner L B; Li Q; Park M S; Flanagan W M; Semenza G L; Dang C V
Hypoxia inhibits G1/S transition through regulation of p27 expression.
The Journal of biological chemistry 2001;276(11):7919-26.
2001: Bos R; Zhong H; Hanrahan C F; Mommers E C; Semenza G L; Pinedo H M; Abeloff M D; Simons J W; van Diest P J; van der Wall E
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.
Journal of the National Cancer Institute 2001;93(4):309-14.
2001: Semenza G L; Artemov D; Bedi A; Bhujwalla Z; Chiles K; Feldser D; Laughner E; Ravi R; Simons J; Taghavi P; Zhong H
'The metabolism of tumours': 70 years later.
Novartis Foundation symposium 2001;240():251-60; discussion 260-4.
2000: Semenza G L
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.
The Journal of clinical investigation 2000;106(7):809-12.
2000: Bergeron M; Gidday J M; Yu A Y; Semenza G L; Ferriero D M; Sharp F R
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain.
Annals of neurology 2000;48(3):285-96.
2000: Rivard A; Berthou-Soulie L; Principe N; Kearney M; Curry C; Branellec D; Semenza G L; Isner J M
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity.
The Journal of biological chemistry 2000;275(38):29643-7.
2000: Semenza G L
HIF-1 and human disease: one highly involved factor.
Genes & development 2000;14(16):1983-91.
2000: Zagzag D; Friedlander D R; Margolis B; Grumet M; Semenza G L; Zhong H; Simons J W; Holash J; Wiegand S J; Yancopoulos G D
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: Zagzag D; Zhong H; Scalzitti J M; Laughner E; Simons J W; Semenza G L
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.
Cancer 2000;88(11):2606-18.
2000: Sutter C H; Laughner E; Semenza G L
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4748-53.
2000: Semenza G L
HIF-1: mediator of physiological and pathophysiological responses to hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(4):1474-80.
2000: Zhong H; Chiles K; Feldser D; Laughner E; Hanrahan C; Georgescu M M; Simons J W; Semenza G L
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
Cancer research 2000;60(6):1541-5.
2000: Becker P M; Alcasabas A; Yu A Y; Semenza G L; Bunton T E
Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs.
American journal of respiratory cell and molecular biology 2000;22(3):272-9.
2000: Semenza G L
Cellular and molecular dissection of reperfusion injury: ROS within and without.
Circulation research 2000;86(2):117-8.
2000: Ravi R; Mookerjee B; Bhujwalla Z M; Sutter C H; Artemov D; Zeng Q; Dillehay L E; Madan A; Semenza G L; Bedi A
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
Genes & development 2000;14(1):34-44.
2000: Semenza G L
Expression of hypoxia-inducible factor 1: mechanisms and consequences.
Biochemical pharmacology 2000;59(1):47-53.
2000: Semenza G L
Oxygen-regulated transcription factors and their role in pulmonary disease.
Respiratory research 2000;1(3):159-62.
2000: Semenza G L
HIF-1: using two hands to flip the angiogenic switch.
Cancer metastasis reviews 2000;19(1-2):59-65.
2000: Semenza G L
Chairman's summary: mechanisms of oxygen homeostasis, circa 1999.
Advances in experimental medicine and biology 2000;475():303-10.
2000: Semenza G L; Agani F; Feldser D; Iyer N; Kotch L; Laughner E; Yu A
Hypoxia, HIF-1, and the pathophysiology of common human diseases.
Advances in experimental medicine and biology 2000;475():123-30.
2000: Semenza G L
Hypoxia, clonal selection, and the role of HIF-1 in tumor progression.
Critical reviews in biochemistry and molecular biology 2000;35(2):71-103.
1999: Bergeron M; Yu A Y; Solway K E; Semenza G L; Sharp F R
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain.
The European journal of neuroscience 1999;11(12):4159-70.
1999: Zhong H; De Marzo A M; Laughner E; Lim M; Hilton D A; Zagzag D; Buechler P; Isaacs W B; Semenza G L; Simons J W
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Cancer research 1999;59(22):5830-5.
1999: Zaman K; Ryu H; Hall D; O'Donovan K; Lin K I; Miller M P; Marquis J C; Baraban J M; Semenza G L; Ratan R R
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9821-30.
1999: Feldser D; Agani F; Iyer N V; Pak B; Ferreira G; Semenza G L
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
Cancer research 1999;59(16):3915-8.
1999: Semenza G L
Perspectives on oxygen sensing.
Cell 1999;98(3):281-4.
1999: Yu A; Alcasabas A; Semenza G; Becker P
Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia.
Chest 1999;116(1 Suppl):32S.
1999: Semenza G L; Agani F; Iyer N; Kotch L; Laughner E; Leung S; Yu A
Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.
Annals of the New York Academy of Sciences 1999;874():262-8.
1999: Kotch L E; Iyer N V; Laughner E; Semenza G L
Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death.
Developmental biology 1999;209(2):254-67.
1999: Yu A Y; Shimoda L A; Iyer N V; Huso D L; Sun X; McWilliams R; Beaty T; Sham J S; Wiener C M; Sylvester J T; Semenza G L
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha.
The Journal of clinical investigation 1999;103(5):691-6.
1999: Dang C V; Semenza G L
Oncogenic alterations of metabolism.
Trends in biochemical sciences 1999;24(2):68-72.
1999: Ozaki H; Yu A Y; Della N; Ozaki K; Luna J D; Yamada H; Hackett S F; Okamoto N; Zack D J; Semenza G L; Campochiaro P A
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
Investigative ophthalmology & visual science 1999;40(1):182-9.
1999: Semenza G L
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.
Annual review of cell and developmental biology 1999;15():551-78.
1998: Zhong H; Agani F; Baccala A A; Laughner E; Rioseco-Camacho N; Isaacs W B; Simons J W; Semenza G L
Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.
Cancer research 1998;58(23):5280-4.
1998: Agani F; Semenza G L
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Molecular pharmacology 1998;54(5):749-54.
1998: Semenza G L
Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
Current opinion in genetics & development 1998;8(5):588-94.
1998: Yu A Y; Frid M G; Shimoda L A; Wiener C M; Stenmark K; Semenza G L
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung.
The American journal of physiology 1998;275(4 Pt 1):L818-26.
1998: Iyer N V; Leung S W; Semenza G L
The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation.
Genomics 1998;52(2):159-65.
1998: Semenza G L; Agani F; Iyer N; Jiang B H; Leung S; Wiener C; Yu A
Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology.
Chest 1998;114(1 Suppl):40S-45S.
1998: Liu Y; Christou H; Morita T; Laughner E; Semenza G L; Kourembanas S
Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer.
The Journal of biological chemistry 1998;273(24):15257-62.
1998: Martin C; Yu A Y; Jiang B H; Davis L; Kimberly D; Hohimer A R; Semenza G L
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1.
American journal of obstetrics and gynecology 1998;178(3):527-34.
1998: Semenza G L
Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis.
The Journal of laboratory and clinical medicine 1998;131(3):207-14.
1998: Palmer L A; Semenza G L; Stoler M H; Johns R A
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1.
The American journal of physiology 1998;274(2 Pt 1):L212-9.
1998: Iyer N V; Kotch L E; Agani F; Leung S W; Laughner E; Wenger R H; Gassmann M; Gearhart J D; Lawler A M; Yu A Y; Semenza G L
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.
Genes & development 1998;12(2):149-62.
1997: Jiang B H; Agani F; Passaniti A; Semenza G L
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.
Cancer research 1997;57(23):5328-35.
1997: Agani F; Kirsch D G; Friedman S L; Kastan M B; Semenza G L
p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
Cancer research 1997;57(20):4474-7.
1997: Jiang B H; Zheng J Z; Leung S W; Roe R; Semenza G L
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
The Journal of biological chemistry 1997;272(31):19253-60.
1997: Winograd J; Reilly M P; Roe R; Lutz J; Laughner E; Xu X; Hu L; Asakura T; vander Kolk C; Strandberg J D; Semenza G L
Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.
Human molecular genetics 1997;6(3):369-79.
1997: Doheny K F; Rasmussen S A; Rutberg J; Semenza G L; Stamberg J; Schwartz M; Batista D A; Stetten G; Thomas G H
Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins.
American journal of medical genetics 1997;69(2):188-93.
1997: Lee P J; Jiang B H; Chin B Y; Iyer N V; Alam J; Semenza G L; Choi A M
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia.
The Journal of biological chemistry 1997;272(9):5375-81.
1997: Semenza G L; Agani F; Booth G; Forsythe J; Iyer N; Jiang B H; Leung S; Roe R; Wiener C; Yu A
Structural and functional analysis of hypoxia-inducible factor 1.
Kidney international 1997;51(2):553-5.
1996: Semenza G L; Jiang B H; Leung S W; Passantino R; Concordet J P; Maire P; Giallongo A
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
The Journal of biological chemistry 1996;271(51):32529-37.
1996: Jiang B H; Semenza G L; Bauer C; Marti H H
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
The American journal of physiology 1996;271(4 Pt 1):C1172-80.
1996: Forsythe J A; Jiang B H; Iyer N V; Agani F; Leung S W; Koos R D; Semenza G L
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Molecular and cellular biology 1996;16(9):4604-13.
1996: Wiener C M; Booth G; Semenza G L
In vivo expression of mRNAs encoding hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1996;225(2):485-8.
1996: Jiang B H; Rue E; Wang G L; Roe R; Semenza G L
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.
The Journal of biological chemistry 1996;271(30):17771-8.
1996: Semenza G L; Rue E A; Iyer N V; Pang M G; Kearns W G
Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q.
Genomics 1996;34(3):437-9.
1995: Wang G L; Jiang B H; Semenza G L
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1995;216(2):669-75.
1995: Sokol L; Luhovy M; Guan Y; Prchal J F; Semenza G L; Prchal J T
Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin.
Blood 1995;86(1):15-22.
1995: Wang G L; Jiang B H; Semenza G L
Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.
Biochemical and biophysical research communications 1995;212(2):550-6.
1995: Prchal J T; Semenza G L; Prchal J; Sokol L
Familial polycythemia.
Science (New York, N.Y.) 1995;268(5219):1831-2.
1995: Wang G L; Jiang B H; Rue E A; Semenza G L
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5510-4.
1995: Semenza G L; Wang G L; Kundu R
DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2.
Biochemical and biophysical research communications 1995;209(1):257-62.
1995: Wang G L; Semenza G L
Purification and characterization of hypoxia-inducible factor 1.
The Journal of biological chemistry 1995;270(3):1230-7.
1994: Semenza G L
Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis.
Hematology/oncology clinics of North America 1994;8(5):863-84.
1994: Semenza G L; Roth P H; Fang H M; Wang G L
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
The Journal of biological chemistry 1994;269(38):23757-63.
1994: Semenza G L
Erythropoietin gene expression in transgenic mice and human hepatoma cells.
Annals of the New York Academy of Sciences 1994;718():41-7; discussion 47-9.
1994: Semenza G L
Transcriptional regulation of gene expression: mechanisms and pathophysiology.
Human mutation 1994;3(3):180-99.
1993: Wang G L; Semenza G L
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Blood 1993;82(12):3610-5.
1993: Wang G L; Semenza G L
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
The Journal of biological chemistry 1993;268(29):21513-8.
1993: Wang G L; Semenza G L
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4304-8.
1993: Koury S T; Bondurant M C; Semenza G L; Koury M J
The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver.
Microscopy research and technique 1993;25(1):29-39.
1992: Semenza G L; Wang G L
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Molecular and cellular biology 1992;12(12):5447-54.
1991: Semenza G L; Koury S T; Nejfelt M K; Gearhart J D; Antonarakis S E
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8725-9.
1991: Semenza G L; Nejfelt M K; Chi S M; Antonarakis S E
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5680-4.
1991: Bondurant M C; Koury M J; Koury S T; Semenza G
Erythropoietin ontogeny and organ distribution in mice.
Seminars in hematology 1991;28(3 Suppl 3):20-5; discussion 26-7.
1991: Koury S T; Bondurant M C; Koury M J; Semenza G L
Localization of cells producing erythropoietin in murine liver by in situ hybridization.
Blood 1991;77(11):2497-503.
1990: Semenza G L; Dureza R C; Traystman M D; Gearhart J D; Antonarakis S E
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.
Molecular and cellular biology 1990;10(3):930-8.
1989: Semenza G L; Traystman M D; Gearhart J D; Antonarakis S E
Polycythemia in transgenic mice expressing the human erythropoietin gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2301-5.
1989: Semenza G L; Dowling C E; Kazazian H H
Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR).
Nucleic acids research 1989;17(6):2376.
1988: Semenza G L; Pyeritz R E
Respiratory complications of mucopolysaccharide storage disorders.
Medicine 1988;67(4):209-19.
1987: Semenza G L; Ladias J A; Antonarakis S E
An Xba I polymorphism 3' to the human erythropoietin (EPO) gene.
Nucleic acids research 1987;15(16):6768.
1984: Semenza G L; Delgrosso K; Poncz M; Malladi P; Schwartz E; Surrey S
The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions.
Cell 1984;39(1):123-8.
1984: Semenza G L; Malladi P; Surrey S; Delgrosso K; Poncz M; Schwartz E
Detection of a novel DNA polymorphism in the beta-globin gene cluster.
The Journal of biological chemistry 1984;259(10):6045-8.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Gregg Semenza

Research Profile (preview)

Chemicals & Drugs

Living Beings

Disorders

Physiology

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Gregg Semenza (preview)

All Publications