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Michelle Blaskovich
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Research Profile (preview)
Chemicals & Drugs
Living Beings
Physiology
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Occupations
Anatomy
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Network (preview)
31
Sebti, Said
21
Hamilton, Andrew
11
Ohkanda, Junko
9
Qian, Yimin
5
Vogt, Andreas
4
Davies, P
4
Bucher, Cynthia
4
Carrico, Dora
4
Coppola, Domenico
3
Delarue, Frederic
3
Pitt, Bruce
3
Lockman, Jeffrey
3
Mcguire, Terence
3
Jove, Richard
2
Wang, De-an
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Geonetwork of Michelle Blaskovich (preview)
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All Publications
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2009: Hong David S; Sebti Said M; Newman Robert A; Blaskovich Michelle A; Ye Lei; Gagel Robert F; Moulder Stacy; Wheler Jennifer J; Naing Aung; Tannir Nizar M; Ng Chaan S; Sherman Steven I; El Naggar Adel K; Khan Rabia; Trent Jon; Wright John J; Kurzrock Razelle
Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):7061-8.
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2009: Kazi Aslamuzzaman; Carie Adam; Blaskovich Michelle A; Bucher Cynthia; Thai Van; Moulder Stacy; Peng Hairuo; Carrico Dora; Pusateri Erin; Pledger Warren J; Berndt Norbert; Hamilton Andrew; Sebti Saïd M
Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.
Molecular and cellular biology 2009;29(8):2254-63.
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2009: Hast Michael A; Fletcher Steven; Cummings Christopher G; Pusateri Erin E; Blaskovich Michelle A; Rivas Kasey; Gelb Michael H; Van Voorhis Wesley C; Sebti Said M; Hamilton Andrew D; Beese Lorena S
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Chemistry & biology 2009;16(2):181-92.
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2008: Epling-Burnette P K; Sokol Lubomir; Chen Xianhong; Bai Fanqi; Zhou Junmin; Blaskovich Michelle A; Zou JianXiang; Painter Jeffrey S; Edwards Todd D; Moscinski Lynn; Yoder Jeffrey A; Djeu Julie Y; Sebti Said; Loughran Thomas P; Wei Sheng
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.
Blood 2008;112(12):4694-8.
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2008: Machida Shinnosuke; Usuba Kakeru; Blaskovich Michelle A; Yano Akiko; Harada Kazuo; Sebti Saïd M; Kato Nobuo; Ohkanda Junko
Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(5):1392-401.
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2007: Siddiquee Khandaker; Zhang Shumin; Guida Wayne C; Blaskovich Michelle A; Greedy Benjamin; Lawrence Harshani R; Yip M L Richard; Jove Richard; McLaughlin Mark M; Lawrence Nicholas J; Sebti Said M; Turkson James
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7391-6.
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2007: Epifano Francesco; Curini Massimo; Genovese Salvatore; Blaskovich Michelle; Hamilton Andrew; Sebti Said M
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
Bioorganic & medicinal chemistry letters 2007;17(9):2639-42.
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2007: Delarue F L; Adnane J; Joshi B; Blaskovich M A; Wang D-A; Hawker J; Bizouarn F; Ohkanda J; Zhu K; Hamilton A D; Chellappan S; Sebti S M
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene 2007;26(5):633-40.
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2006: Peng Hairuo; Carrico Dora; Thai Van; Blaskovich Michelle; Bucher Cynthia; Pusateri Erin E; Sebti Said M; Hamilton Andrew D
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Organic & biomolecular chemistry 2006;4(9):1768-84.
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2006: Ohkanda Junko; Strickland Corey L; Blaskovich Michelle A; Carrico Dora; Lockman Jeffrey W; Vogt Andreas; Bucher Cynthia J; Sun Jiazhi; Qian Yimin; Knowles David; Pusateri Erin E; Sebti Saïd M; Hamilton Andrew D
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
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2005: Nefedova Yulia; Cheng Pingyan; Gilkes Daniele; Blaskovich Michelle; Beg Amer A; Sebti Said M; Gabrilovich Dmitry I
Activation of dendritic cells via inhibition of Jak2/STAT3 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4338-46.
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2005: Sun Jiazhi; Wang De-An; Jain Rishi K; Carie Adam; Paquette Steve; Ennis Eileen; Blaskovich Michelle A; Baldini Laura; Coppola Domenico; Hamilton Andrew D; Sebti Saïd M
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
Oncogene 2005;24(29):4701-9.
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2005: Sun Jiazhi; Blaskovich Michelle A; Jove Richard; Livingston Sandra K; Coppola Domenico; Sebti Saïd M
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.
Oncogene 2005;24(20):3236-45.
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2005: Carrico Dora; Blaskovich Michelle A; Bucher Cynthia J; Sebti Saïd M; Hamilton Andrew D
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry 2005;13(3):677-88.
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2004: Carrico Dora; Ohkanda Junko; Kendrick Howard; Yokoyama Kohei; Blaskovich Michelle A; Bucher Cynthia J; Buckner Frederick S; Van Voorhis Wesley C; Chakrabarti Debopam; Croft Simon L; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
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2004: Gasparetto Maura; Gentry Tracy; Sebti Said; O'Bryan Erica; Nimmanapalli Ramadevi; Blaskovich Michelle A; Bhalla Kapil; Rizzieri David; Haaland Perry; Dunne Jack; Smith Clay
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening.
Journal of immunological methods 2004;292(1-2):59-71.
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2004: Sun Jiazhi; Blaskovich Michelle A; Jain Rishi K; Delarue Frederic; Paris Daniel; Brem Steven; Wotoczek-Obadia Marguerite; Lin Qing; Coppola Domenico; Choi Kihang; Mullan Michael; Hamilton Andrew D; Sebti Saïd M
Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Cancer research 2004;64(10):3586-92.
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2003: Blaskovich Michelle A; Sun Jiazhi; Cantor Alan; Turkson James; Jove Richard; Sebti Saïd M
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
Cancer research 2003;63(6):1270-9.
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2003: Ohkanda Junko; Blaskovich Michelle A; Sebti Saïd M; Hamilton Andrew D
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Progress in cell cycle research 2003;5():211-7.
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2002: Ohkanda Junko; Knowles David B; Blaskovich Michelle A; Sebti Said M; Hamilton Andrew D
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Current topics in medicinal chemistry 2002;2(3):303-23.
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2002: Ohkanda Junko; Lockman Jeffrey W; Kothare Mohit A; Qian Yimin; Blaskovich Michelle A; Sebti Said M; Hamilton Andrew D
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
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2001: Ohkanda J; Lockman J W; Yokoyama K; Gelb M H; Croft S L; Kendrick H; Harrell M I; Feagin J E; Blaskovich M A; Sebti S M; Hamilton A D
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
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2000: Blaskovich M A; Lin Q; Delarue F L; Sun J; Park H S; Coppola D; Hamilton A D; Sebti S M
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
Nature biotechnology 2000;18(10):1065-70.
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2000: Boota A; Johnson B; Lee K L; Blaskovich M A; Liu S X; Kagan V E; Hamilton A; Pitt B; Sebti S M; Davies P
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L329-34.
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1999: Sun J; Blaskovich M A; Knowles D; Qian Y; Ohkanda J; Bailey R D; Hamilton A D; Sebti S M
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer research 1999;59(19):4919-26.
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1999: Vasudevan A; Qian Y; Vogt A; Blaskovich M A; Ohkanda J; Sebti S M; Hamilton A D
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
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1998: Kucich U; Rosenbloom J C; Shen G; Abrams W R; Blaskovich M A; Hamilton A D; Ohkanda J; Sebti S M; Rosenbloom J
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochemical and biophysical research communications 1998;252(1):111-6.
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1998: Stark W W; Blaskovich M A; Johnson B A; Qian Y; Vasudevan A; Pitt B; Hamilton A D; Sebti S M; Davies P
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The American journal of physiology 1998;275(1 Pt 1):L55-63.
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1997: Finder J D; Litz J L; Blaskovich M A; McGuire T F; Qian Y; Hamilton A D; Davies P; Sebti S M
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(21):13484-8.
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1996: Xu X Q; McGuire T F; Blaskovich M A; Sebti S M; Romero G
Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts.
Archives of biochemistry and biophysics 1996;326(2):233-7.
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1995: Lerner E C; Qian Y; Blaskovich M A; Fossum R D; Vogt A; Sun J; Cox A D; Der C J; Hamilton A D; Sebti S M
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
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1995: McGuire T F; Qian Y; Blaskovich M A; Fossum R D; Sun J; Marlowe T; Corey S J; Wathen S P; Vogt A; Hamilton A D
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
Biochemical and biophysical research communications 1995;214(1):295-303.
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1995: Vogt A; Qian Y; Blaskovich M A; Fossum R D; Hamilton A D; Sebti S M
A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
The Journal of biological chemistry 1995;270(2):660-4.
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1994: Weng W; Reynolds I J; Jani J P; Blaskovich M; Sebti S M; Davies P; Pitt B R
Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture.
Microcirculation (New York, N.Y. : 1994) 1994;1(2):129-35.
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1994: Qian Y; Blaskovich M A; Saleem M; Seong C M; Wathen S P; Hamilton A D; Sebti S M
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.
The Journal of biological chemistry 1994;269(17):12410-3.
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