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John Semmes

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Proteomics

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Human T-lymphotropic virus 1

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Cazares Lisa H; Troyer Dean; Mendrinos Savvas; Lance Raymond A; Nyalwidhe Julius O; Beydoun Hind A; Clements Mary Ann; Drake Richard R; Semmes O John
Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue.
Karbassi Izabela D; Nyalwidhe Julius O; Wilkins Christopher E; Cazares Lisa H; Lance Raymond S; Semmes O John; Drake Richard R
Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF.
Kesic Matthew; Ward Michael; Semmes O John; Green Patrick L
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo.

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2009: Cazares Lisa H; Troyer Dean; Mendrinos Savvas; Lance Raymond A; Nyalwidhe Julius O; Beydoun Hind A; Clements Mary Ann; Drake Richard R; Semmes O John
Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5541-51.
2009: Karbassi Izabela D; Nyalwidhe Julius O; Wilkins Christopher E; Cazares Lisa H; Lance Raymond S; Semmes O John; Drake Richard R
Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF.
Journal of proteome research 2009;8(9):4182-92.
2009: Kesic Matthew; Ward Michael; Semmes O John; Green Patrick L
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo.
Journal of virology 2009;83(17):8859-68.
2009: Drake Richard R; White Krista Y; Fuller Thomas W; Igwe Elena; Clements Mary Ann; Nyalwidhe Julius O; Given Robert W; Lance Raymond S; Semmes O John
Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease.
Journal of proteomics 2009;72(6):907-17.
2009: Fryrear Kimberly A; Durkin Sarah S; Gupta Saurabh K; Tiedebohl Jessica B; Semmes O John
Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization.
Journal of virology 2009;83(11):5339-52.
2009: Schaub Nicholas P; Jones Kimberly J; Nyalwidhe Julius O; Cazares Lisa H; Karbassi Izabela D; Semmes O John; Feliberti Eric C; Perry Roger R; Drake Richard R
Serum proteomic biomarker discovery reflective of stage and obesity in breast cancer patients.
Journal of the American College of Surgeons 2009;208(5):970-8; discussion 978-80.
2009: White Krista Y; Rodemich Lucy; Nyalwidhe Julius O; Comunale Mary Ann; Clements Mary Ann; Lance Raymond S; Schellhammer Paul F; Mehta Anand S; Semmes O John; Drake Richard R
Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids.
Journal of proteome research 2009;8(2):620-30.
2009: Kesic Matthew; Doueiri Rami; Ward Michael; Semmes O John; Green Patrick L
Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.
Retrovirology 2009;6():105.
2008: Sturgeon Catharine M; Hoffman Barry R; Chan Daniel W; Ch'ng Soo-Ling; Hammond Elizabeth; Hayes Daniel F; Liotta Lance A; Petricoin Emmanuel F; Schmitt Manfred; Semmes O John; Söletormos Györg; van der Merwe Elena; Diamandis Eleftherios P;
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in clinical practice: quality requirements.
Clinical chemistry 2008;54(8):e1-e10.
2008: Qi Lining; Cazares Lisa; Johnson Cris; de Alarcon Pedro; Kupfer Gary M; Semmes O John
Serum protein expression profiling in pediatric Hodgkin lymphoma: a report from the Children's Oncology Group.
Pediatric blood & cancer 2008;51(2):216-21.
2008: Hair Pamela S; Ward Michael D; Semmes O John; Foster Timothy J; Cunnion Kenji M
Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b.
The Journal of infectious diseases 2008;198(1):125-33.
2008: Shen Weiping; Westgard Elizabeth; Huang Liqun; Ward Michael D; Osborn Jodi L; Chau Nha H; Collins Lindsay; Marcum Benjamin; Koach Margaret A; Bibbs Jennifer; Semmes O John; Kerry Julie A
Nuclear trafficking of the human cytomegalovirus pp71 (ppUL82) tegument protein.
Virology 2008;376(1):42-52.
2008: Tracy Maureen B; Chen Haijian; Weaver Dennis M; Malyarenko Dariya I; Sasinowski Maciek; Cazares Lisa H; Drake Richard R; Semmes O John; Tracy Eugene R; Cooke William E
Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment.
Proteomics 2008;8(8):1530-8.
2008: McLerran Dale F; Feng Ziding; Semmes O John; Cazares Lisa; Randolph Timothy W
Signal detection in high-resolution mass spectrometry data.
Journal of proteome research 2008;7(1):276-85.
2008: Freed Gary L; Cazares Lisa H; Fichandler Craig E; Fuller Thomas W; Sawyer Christopher A; Stack Brendan C; Schraff Scott; Semmes O John; Wadsworth J Trad; Drake Richard R
Differential capture of serum proteins for expression profiling and biomarker discovery in pre- and posttreatment head and neck cancer samples.
The Laryngoscope 2008;118(1):61-8.
2008: McLerran Dale; Grizzle William E; Feng Ziding; Thompson Ian M; Bigbee William L; Cazares Lisa H; Chan Daniel W; Dahlgren Jackie; Diaz Jose; Kagan Jacob; Lin Daniel W; Malik Gunjan; Oelschlager Denise; Partin Alan; Randolph Timothy W; Sokoll Lori; Srivastava Shiv; Srivastava Sudhir; Thornquist Mark; Troyer Dean; Wright George L; Zhang Zhen; Zhu Liu; Semmes O John
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer.
Clinical chemistry 2008;54(1):53-60.
2008: McLerran Dale; Grizzle William E; Feng Ziding; Bigbee William L; Banez Lionel L; Cazares Lisa H; Chan Daniel W; Diaz Jose; Izbicka Elzbieta; Kagan Jacob; Malehorn David E; Malik Gunjan; Oelschlager Denise; Partin Alan; Randolph Timothy; Rosenzweig Nicole; Srivastava Shiv; Srivastava Sudhir; Thompson Ian M; Thornquist Mark; Troyer Dean; Yasui Yutaka; Zhang Zhen; Zhu Liu; Semmes O John
Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.
Clinical chemistry 2008;54(1):44-52.
2008: Ramadan Emad; Ward Michael; Guo Xin; Durkin Sarah S; Sawyer Adam; Vilela Marcelo; Osgood Christopher; Pothen Alex; Semmes Oliver J
Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome.
Retrovirology 2008;5():92.
2008: Cazares Lisa H; Diaz Jose I; Drake Rick R; Semmes O John
MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers.
Methods in molecular biology (Clifton, N.J.) 2008;428():125-40.
2008: Diaz Jose I; Cazares Lisa H; Semmes O John
Tissue sample collection for proteomics analysis.
Methods in molecular biology (Clifton, N.J.) 2008;428():43-53.
2007: Gatlin-Bunai Christine L; Cazares Lisa H; Cooke William E; Semmes Oliver J; Malyarenko Dariya I
Optimization of MALDI-TOF MS detection for enhanced sensitivity of affinity-captured proteins spanning a 100 kDa mass range.
Journal of proteome research 2007;6(11):4517-24.
2007: Malik Gunjan; Rojahn Elizabeth; Ward Michael D; Gretzer Mathew B; Partin Alan W; Semmes O John; Veltri Robert W
SELDI protein profiling of dunning R-3327 derived cell lines: identification of molecular markers of prostate cancer progression.
The Prostate 2007;67(14):1565-75.
2007: Gupta Saurabh K; Guo Xin; Durkin Sarah S; Fryrear Kimberly F; Ward Michael D; Semmes O John
Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.
The Journal of biological chemistry 2007;282(40):29431-40.
2007: Shin Susanna; Cazares Lisa; Schneider Heather; Mitchell Shamina; Laronga Christine; Semmes O John; Perry Roger R; Drake Richard R
Serum biomarkers to differentiate benign and malignant mammographic lesions.
Journal of the American College of Surgeons 2007;204(5):1065-71; discussion 1071-3.
2006: Durkin Sarah S; Ward Michael D; Fryrear Kimberly A; Semmes O John
Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein.
The Journal of biological chemistry 2006;281(42):31705-12.
2006: Drake Richard R; Schwegler E Ellen; Malik Gunjan; Diaz Jose; Block Timothy; Mehta Anand; Semmes O John
Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers.
Molecular & cellular proteomics : MCP 2006;5(10):1957-67.
2006: Semmes O John; Malik Gunjan; Ward Mike
Application of mass spectrometry to the discovery of biomarkers for detection of prostate cancer.
Journal of cellular biochemistry 2006;98(3):496-503.
2006: Semmes O John
Adult T cell leukemia: a tale of two T cells.
The Journal of clinical investigation 2006;116(4):858-60.
2006: Holterman Daniel A; Diaz Jose I; Blackmore Peter F; Davis John W; Schellhammer Paul F; Corica Alberto; Semmes Oliver J; Vlahou Antonia
Overexpression of alpha-defensin is associated with bladder cancer invasiveness.
Urologic oncology 2006;24(2):97-108.
2006: Xie Li; Yamamoto Brenda; Haoudi Abdelali; Semmes O John; Green Patrick L
PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo.
Blood 2006;107(5):1980-8.
2006: Belgnaoui S Mehdi; Gosden Roger G; Semmes O John; Haoudi Abdelali
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells.
Cancer cell international 2006;6():13.
2006: Malyarenko Dariya I; Cooke William E; Tracy Eugene R; Drake Richard R; Shin Susanna; Semmes O John; Sasinowski Maciek; Manos Dennis M
Resampling and deconvolution of linear time-of-flight records for enhanced protein profiling.
Rapid communications in mass spectrometry : RCM 2006;20(11):1670-8.
2006: Malyarenko Dariya I; Cooke William E; Tracy Eugene R; Trosset Michael W; Semmes O John; Sasinowski Maciek; Manos Dennis M
Deconvolution filters to enhance resolution of dense time-of-flight survey spectra in the time-lag optimization range.
Rapid communications in mass spectrometry : RCM 2006;20(11):1661-9.
2005: Semmes O John
The "omics" haystack: defining sources of sample bias in expression profiling.
Clinical chemistry 2005;51(9):1571-2.
2005: Rai Alex J; Stemmer Paul M; Zhang Zhen; Adam Bao-Ling; Morgan William T; Caffrey Rebecca E; Podust Vladimir N; Patel Manisha; Lim Lih-Yin; Shipulina Natalia V; Chan Daniel W; Semmes O John; Leung Hon-Chiu Eastwood
Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: multi-institution correlation of spectra and identification of biomarkers.
Proteomics 2005;5(13):3467-74.
2005: Semmes O J; Cazares L H; Ward M D; Qi L; Moody M; Maloney E; Morris J; Trosset M W; Hisada M; Gygi S; Jacobson S
Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(7):1229-38.
2005: Bensmail Halima; Aruna Buddana; Semmes O John; Haoudi Abdelali
Functional clustering algorithm for high-dimensional proteomics data.
Journal of biomedicine & biotechnology 2005;2005(2):80-6.
2005: Forgacs Eva; Gupta Saurabh K; Kerry Julie A; Semmes O John
The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.
Journal of virology 2005;79(11):6932-9.
2005: Schwegler E Ellen; Cazares Lisa; Steel Laura F; Adam Bao-Ling; Johnson David A; Semmes O John; Block Timothy M; Marrero Jorge A; Drake Richard R
SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2005;41(3):634-42.
2005: Malik Gunjan; Ward Michael D; Gupta Saurabh K; Trosset Michael W; Grizzle William E; Adam Bao-Ling; Diaz Jose I; Semmes O John
Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1073-85.
2005: Drake Richard R; Cazare Lisa H; Semmes O John; Wadsworth J Trad
Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers.
Expert review of molecular diagnostics 2005;5(1):93-100.
2005: Semmes O John; Feng Ziding; Adam Bao-Ling; Banez Lionel L; Bigbee William L; Campos David; Cazares Lisa H; Chan Daniel W; Grizzle William E; Izbicka Elzbieta; Kagan Jacob; Malik Gunjan; McLerran Dale; Moul Judd W; Partin Alan; Prasanna Premkala; Rosenzweig Jason; Sokoll Lori J; Srivastava Shiv; Srivastava Sudhir; Thompson Ian; Welsh Manda J; White Nicole; Winget Marcy; Yasui Yutaka; Zhang Zhen; Zhu Liu
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility.
Clinical chemistry 2005;51(1):102-12.
2005: Malyarenko Dariya I; Cooke William E; Adam Bao-Ling; Malik Gunjan; Chen Haijian; Tracy Eugene R; Trosset Michael W; Sasinowski Maciek; Semmes O John; Manos Dennis M
Enhancement of sensitivity and resolution of surface-enhanced laser desorption/ionization time-of-flight mass spectrometric records for serum peptides using time-series analysis techniques.
Clinical chemistry 2005;51(1):65-74.
2005: Grizzle William E; Semmes O John; Bigbee William; Zhu Liu; Malik Gunjan; Oelschlager Denise K; Manne Barkha; Manne Upender
The Need for Review and Understanding of SELDI/MALDI Mass Spectroscopy Data Prior to Analysis.
Cancer informatics 2005;1():86-97.
2005: Grizzle William E; Semmes O John; Bigbee William; Zhu Liu; Malik Gunjan; Oelschlager Denise K; Manne Barkha; Manne Upender
The Need for Review and Understanding of SELDI/MALDI Mass Spectroscopy Data Prior to Analysis.
Cancer informatics 2005;1():86-97.
2004: Gelmann Edward P; Semmes O John
Expression of genes and proteins specific for prostate cancer.
The Journal of urology 2004;172(5 Pt 2):S23-6; discussion S26-7.
2004: Semmes O John
Defining the role of mass spectrometry in cancer diagnostics.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(10):1555-7.
2004: Becker Stephen; Cazares Lisa H; Watson Patrice; Lynch Henry; Semmes O John; Drake Richard R; Laronga Christine
Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer.
Annals of surgical oncology 2004;11(10):907-14.
2004: Vlahou Antonia; Giannopoulos Aris; Gregory Betsy W; Manousakas Theodoros; Kondylis Filippos I; Wilson Lori L; Schellhammer Paul F; Wright George L; Semmes O John
Protein profiling in urine for the diagnosis of bladder cancer.
Clinical chemistry 2004;50(8):1438-41.
2004: Grizzle William E; Semmes O John; Basler Joseph; Izbicka Elzbieta; Feng Ziding; Kagan Jacob; Adam Bao-Ling; Troyer Dean; Srivastava Sudhir; Thornquist Mark; Zhang Zhen; Thompson Ian M
The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology.
Urologic oncology 2004;22(4):337-43.
2004: Pusztai Lajos; Gregory Betsy W; Baggerly Keith A; Peng Bo; Koomen John; Kuerer Henry M; Esteva Francisco J; Symmans W Fraser; Wagner Peter; Hortobagyi Gabriel N; Laronga Christine; Semmes O John; Wright George L; Drake Richard R; Vlahou Antonia
Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma.
Cancer 2004;100(9):1814-22.
2004: Wagner Michael; Naik Dayanand N; Pothen Alex; Kasukurti Srinivas; Devineni Raghu Ram; Adam Bao-Ling; Semmes O John; Wright George L
Computational protein biomarker prediction: a case study for prostate cancer.
BMC bioinformatics 2004;5():26.
2004: Wadsworth J Trad; Somers Kenneth D; Cazares Lisa H; Malik Gunjan; Adam Bao-Ling; Stack Brendan C; Wright George L; Semmes O John
Serum protein profiles to identify head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1625-32.
2004: Comunale Mary Ann; Mattu Taj S; Lowman Melissa A; Evans Alison A; London W Thomas; Semmes O John; Ward Michael; Drake Richard; Romano Patrick R; Steel Laura F; Block Timothy M; Mehta Anand
Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status.
Proteomics 2004;4(3):826-38.
2004: Wadsworth J Trad; Somers Kenneth D; Stack Brendan C; Cazares Lisa; Malik Gunjan; Adam Bao-Ling; Wright George L; Semmes O John
Identification of patients with head and neck cancer using serum protein profiles.
Archives of otolaryngology--head & neck surgery 2004;130(1):98-104.
2004: Liggett Walter S; Barker Peter E; Semmes O John; Cazares Lisa H
Measurement reproducibility in the early stages of biomarker development.
Disease markers 2004;20(6):295-307.
2003: Twizere Jean-Claude; Kruys Véronique; Lefèbvre Laurent; Vanderplasschen Alain; Collete Delphine; Debacq Christophe; Lai Wi S; Jauniaux Jean-Claude; Bernstein Lori R; Semmes O John; Burny Arsène; Blackshear Perry J; Kettmann Richard; Willems Luc
Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Journal of the National Cancer Institute 2003;95(24):1846-59.
2003: Haoudi Abdelali; Daniels Rodney C; Wong Eric; Kupfer Gary; Semmes O John
Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response.
The Journal of biological chemistry 2003;278(39):37736-44.
2003: Vlahou Antonia; Laronga Christine; Wilson Lori; Gregory Betsy; Fournier Keith; McGaughey Dean; Perry Roger R; Wright George L; Semmes O John
A novel approach toward development of a rapid blood test for breast cancer.
Clinical breast cancer 2003;4(3):203-9.
2003: Haoudi Abdelali; Semmes O John
The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells.
Virology 2003;305(2):229-39.
2003: Laronga Christine; Becker Stephen; Watson Patrice; Gregory Betsy; Cazares Lisa; Lynch Henry; Perry Roger R; Wright George L; Drake Richard R; Semmes O John
SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers.
Disease markers 2003;19(4-5):229-38.
2003: Grizzle William E; Adam Bao-Ling L; Bigbee William L; Conrads Thomas P; Carroll Christopher; Feng Ziding; Izbicka Elzbieta; Jendoubi Moncef; Johnsey Donald; Kagan Jacob; Leach Robin J; McCarthy Diane B; Semmes O John; Srivastava Shiv; Srivastava Sudhir; Thompson Ian M; Thornquist Mark D; Verma Mukesh; Zhang Zhen; Zou Zhiqiang
Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer.
Disease markers 2003;19(4-5):185-95.
2002: Qu Yinsheng; Adam Bao-Ling; Yasui Yutaka; Ward Michael D; Cazares Lisa H; Schellhammer Paul F; Feng Ziding; Semmes O John; Wright George L
Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients.
Clinical chemistry 2002;48(10):1835-43.
2002: Cazares Lisa H; Adam Bao-Ling; Ward Michael D; Nasim Suhail; Schellhammer Paul F; Semmes O John; Wright George L
Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2541-52.
2002: Adam Bao-Ling; Qu Yinsheng; Davis John W; Ward Michael D; Clements Mary Ann; Cazares Lisa H; Semmes O John; Schellhammer Paul F; Yasui Yutaka; Feng Ziding; Wright George L
Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men.
Cancer research 2002;62(13):3609-14.
2001: Adam B L; Vlahou A; Semmes O J; Wright G L
Proteomic approaches to biomarker discovery in prostate and bladder cancers.
Proteomics 2001;1(10):1264-70.
2001: Chen L; Liao G; Fujimuro M; Semmes O J; Hayward S D
Properties of two EBV Mta nuclear export signal sequences.
Virology 2001;288(1):119-28.
1998: Semmes O J; Chen L; Sarisky R T; Gao Z; Zhong L; Hayward S D
Mta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA.
Journal of virology 1998;72(12):9526-34.
1998: Gao Z; Krithivas A; Finan J E; Semmes O J; Zhou S; Wang Y; Hayward S D
The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins.
Journal of virology 1998;72(11):8559-67.

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John Semmes

Research Profile (preview)

Procedures

Chemicals & Drugs

Occupations

Devices

Disorders

Concepts & Ideas

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