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Timo Seppälä

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TOP 3
Sargo Aalto; Jussi Hirvonen; Valtteri Kaasinen; Nora Hagelberg; Jaana Kajander; Kjell Någren; Timo Seppälä; Juha O Rinne; Harry Scheinin; Jarmo Hietala
The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects.
Anu-Katriina Pesonen; Raili Suojaranta-Ylinen; E Hammarén; Pekka Tarkkila; Timo Seppälä; Per H Rosenberg
Comparison of effects and plasma concentrations of opioids between elderly and middle-aged patients after cardiac surgery.
Sanna Kurling; Aino Kankaanpää; Timo Seppälä
Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in rats.

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All Publications

2009: Sargo Aalto; Jussi Hirvonen; Valtteri Kaasinen; Nora Hagelberg; Jaana Kajander; Kjell Någren; Timo Seppälä; Juha O Rinne; Harry Scheinin; Jarmo Hietala
The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects.
European journal of nuclear medicine and molecular imaging 2009;36(3):475-83.
2009: Anu-Katriina Pesonen; Raili Suojaranta-Ylinen; E Hammarén; Pekka Tarkkila; Timo Seppälä; Per H Rosenberg
Comparison of effects and plasma concentrations of opioids between elderly and middle-aged patients after cardiac surgery.
Acta anaesthesiologica Scandinavica 2009;53(1):101-8.
2008: Sanna Kurling; Aino Kankaanpää; Timo Seppälä
Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Behavioural brain research 2008;189(1):191-201.
2006: Esa Meririnne; Miina Kajos; Aino Kankaanpää; Timo Seppälä
Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.
Basic & clinical pharmacology & toxicology 2006;98(4):346-50.
2006: Mikko Salaspuro; Hannu Alho; Ilona Autti-Rämö; Kari Eskola; Erja Halmesmäki; Antti Holopainen; Satu Kivitie-Kallio; Pirjo Lillsunde; Jouko Lönnqvist; Rauno Mäkelä; Risto Roine; Annikki Savolainen; Kaija Seppä; Timo Seppälä; Ulrich Tacke; Juha Teirilä; Helena Vorma
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(19):2352-3.
2005: Esa Meririnne; Miina Kajos; Aino Kankaanpää; Meri Koistinen; Kalervo Kiianmaa; Timo Seppälä
Rewarding properties of the stereoisomers of 4-methylaminorex: involvement of the dopamine system.
Pharmacology, biochemistry, and behavior 2005;81(4):715-24.
2005: Sanna Kurling; Aino Kankaanpää; Satu Ellermaa; Tuomo Karila; Timo Seppälä
The effect of sub-chronic nandrolone decanoate treatment on dopaminergic and serotonergic neuronal systems in the brains of rats.
Brain research 2005;1044(1):67-75.
2004: Aino Kankaanpää; Teemu Gunnar; Kari Ariniemi; Pirjo Lillsunde; Sirpa Mykkänen; Timo Seppälä
Single-step procedure for gas chromatography-mass spectrometry screening and quantitative determination of amphetamine-type stimulants and related drugs in blood, serum, oral fluid and urine samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;810(1):57-68.
2004: Olga Vekovischeva; Teemu Aitta-Aho; O Echenko; Aino Kankaanpää; Timo Seppälä; Aapo Honkanen; Rolf Sprengel; Esa R Korpi
Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice.
Genes, brain, and behavior 2004;3(5):253-65.
2004: Esa Meririnne; Satu Ellermaa; Aino Kankaanpää; Ali Bardy; Timo Seppälä
Pharmacokinetics and tissue distribution of the stereoisomers of 4-methylaminorex in the rat.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1198-205.
2004: Tuomo Karila; O Hovatta; Timo Seppälä
Concomitant abuse of anabolic androgenic steroids and human chorionic gonadotrophin impairs spermatogenesis in power athletes.
International journal of sports medicine 2004;25(4):257-63.
2004: Esa Meririnne; Timo Seppälä
[Neurobiology behind opioid dependence].
Duodecim; lääketieteellinen aikakauskirja 2004;120(8):951-9.
2003: T A M Karila; J E Karjalainen; M J Mäntysaari; Matti Viitasalo; Timo Seppälä
Anabolic androgenic steroids produce dose-dependant increase in left ventricular mass in power atheletes, and this effect is potentiated by concomitant use of growth hormone.
International journal of sports medicine 2003;24(5):337-43.
2002: Erkki Vartiainen; Timo Seppälä; Pirjo Lillsunde; Pekka Puska
Validation of self reported smoking by serum cotinine measurement in a community-based study.
Journal of epidemiology and community health 2002;56(3):167-70.
2002: Aino Kankaanpää; Esa Meririnne; Timo Seppälä
5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat.
Psychopharmacology 2002;159(4):341-50.
2002: Aino Kankaanpää; Satu Ellermaa; Esa Meririnne; Paula Hirsjärvi; Timo Seppälä
Acute neurochemical and behavioral effects of stereoisomers of 4-methylaminorex in relation to brain drug concentrations.
The Journal of pharmacology and experimental therapeutics 2002;300(2):450-9.
2002: Miia Pärssinen; Timo Seppälä
Steroid use and long-term health risks in former athletes.
Sports medicine (Auckland, N.Z.) 2002;32(2):83-94.
2001: Aino Kankaanpää; Esa Meririnne; Satu Ellermaa; Kari Ariniemi; Timo Seppälä
Detection and assay of cis- and trans-isomers of 4-methylaminorex in urine, plasma and tissue samples.
Forensic science international 2001;121(1-2):57-64.
2001: Esa Meririnne; Aino Kankaanpää; Timo Seppälä
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1- and D2-receptor antagonists.
The Journal of pharmacology and experimental therapeutics 2001;298(2):539-50.
2001: Olga Vekovischeva; D Zamanillo; O Echenko; Timo Seppälä; Mikko Uusi-Oukari; Aapo Honkanen; Peter H Seeburg; Rolf Sprengel; Esa R Korpi
Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(12):4451-9.
2001: Aino Kankaanpää; Esa Meririnne; Kari Ariniemi; Timo Seppälä
Oxalic acid stabilizes dopamine, serotonin, and their metabolites in automated liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 2001;753(2):413-9.
2000: Marco Mattila; Petri J Vainio; M L Nurminen; J Vanakoski; Timo Seppälä
Midazolam 12 mg is moderately counteracted by 250 mg caffeine in man.
International journal of clinical pharmacology and therapeutics 2000;38(12):581-7.
2000: J Vanakoski; Marco Mattila; Timo Seppälä
Driving under light and dark conditions: effects of alcohol and diazepam in young and older subjects.
European journal of clinical pharmacology 2000;56(6-7):453-8.
2000: Miia Pärssinen; Tuomo Karila; V Kovanen; Timo Seppälä
The effect of supraphysiological doses of anabolic androgenic steroids on collagen metabolism.
International journal of sports medicine 2000;21(6):406-11.
2000: Miia Pärssinen; U Kujala; E Vartiainen; S Sarna; Timo Seppälä
Increased premature mortality of competitive powerlifters suspected to have used anabolic agents.
International journal of sports medicine 2000;21(3):225-7.
1999: J Kokkonen; Antti Leinonen; J Tuominen; Timo Seppälä
Comparison of sensitivity between gas chromatography-low-resolution mass spectrometry and gas chromatography-high-resolution mass spectrometry for determining metandienone metabolites in urine.
Journal of chromatography. B, Biomedical sciences and applications 1999;734(2):179-89.
1999: Esa Meririnne; Aino Kankaanpää; J Vanakoski; Pirjo Lillsunde; Timo Seppälä
The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats.
Progress in neuro-psychopharmacology & biological psychiatry 1999;23(4):713-30.
1999: Aapo Honkanen; Janne A V Mikkola; Esa R Korpi; Petri Hyytiä; Timo Seppälä; Liisa Ahtee
Enhanced morphine- and cocaine-induced behavioral sensitization in alcohol-preferring AA rats.
Psychopharmacology 1999;142(3):244-52.
1999: A Zharkovsky; J Katajamäki; Timo Seppälä; Liisa Ahtee
Morphine-induced analgesia in rats withdrawn from concurrent nimodipine and morphine treatment.
Pain 1999;79(2-3):217-22.
1999: Esa Meririnne; Aino Kankaanpää; Pirjo Lillsunde; Timo Seppälä
The effects of diazepam and zolpidem on cocaine- and amphetamine-induced place preference.
Pharmacology, biochemistry, and behavior 1999;62(1):159-64.
1998: T Korte; J Pykäläinen; Timo Seppälä
Drug abuse of Finnish male prisoners in 1995.
Forensic science international 1998;97(2-3):171-83.
1998: Tuomo Karila; Hannu Koistinen; Markku Seppala; Riitta Koistinen; Timo Seppälä
Growth hormone induced increase in serum IGFBP-3 level is reversed by anabolic steroids in substance abusing power athletes.
Clinical endocrinology 1998;49(4):459-63.
1998: J Vanakoski; V Kosunen; Esa Meririnne; Timo Seppälä
Creatine and caffeine in anaerobic and aerobic exercise: effects on physical performance and pharmacokinetic considerations.
International journal of clinical pharmacology and therapeutics 1998;36(5):258-62.
1998: Aino Kankaanpää; Esa Meririnne; Pirjo Lillsunde; Timo Seppälä
The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens.
Pharmacology, biochemistry, and behavior 1998;59(4):1003-9.
1998: Marco Mattila; J Vanakoski; Hely Kalska; Timo Seppälä
Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory.
Pharmacology, biochemistry, and behavior 1998;59(4):917-23.
1998: J Vanakoski; Timo Seppälä
Heat exposure and drugs. A review of the effects of hyperthermia on pharmacokinetics.
Clinical pharmacokinetics 1998;34(4):311-22.
1998: Esa R Korpi; Timo Seppälä
[Alcohol--mechanism of action, interactions and treatment of alcohol abuse].
Duodecim; lääketieteellinen aikakauskirja 1998;114(10):1029-36.
1997: J Vanakoski; Timo Seppälä
Renal excretion of tetracycline is transiently decreased during short-term heat exposure.
International journal of clinical pharmacology and therapeutics 1997;35(5):204-7.
1997: T Korte; J Pykäläinen; Pirjo Lillsunde; Timo Seppälä
Comparison of RapiTest with Emit d.a.u. and GC-MS for the analysis of drugs in urine.
Journal of analytical toxicology 1997;21(1):49-53.
1996: T Karila; V Kosunen; A Leinonen; R Tähtelä; Timo Seppälä
High doses of alcohol increase urinary testosterone-to-epitestosterone ratio in females.
Journal of chromatography. B, Biomedical applications 1996;687(1):109-16.
1996: A Lindqvist; Jarmo Jalonen; Lauri A Laitinen; Timo Seppälä; C Strömberg
The effects of midazolam and ephedrine on post-exercise autonomic chronotropic control of the heart in normal subjects.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 1996;6(6):343-9.
1996: J Vanakoski; Timo Seppälä; Eeva Sievi; E Lunell
Exposure to high ambient temperature increases absorption and plasma concentrations of transdermal nicotine.
Clinical pharmacology and therapeutics 1996;60(3):308-15.
1996: T Karila; R Laaksonen; Kalle Jokelainen; Jaakko-Juhani Himberg; Timo Seppälä
The effects of anabolic androgenic steroids on serum ubiquinone and dolichol levels among steroid abusers.
Metabolism: clinical and experimental 1996;45(7):844-7.
1996: J Vanakoski; Juhana J. Idänpään-Heikkilä; Timo Seppälä
Exposure to high environmental temperature in the sauna does not change plasma indocyanine green (ICG) clearance in healthy subjects.
Pharmacology & toxicology 1996;78(2):94-8.
1996: Pirjo Lillsunde; T Korte; L Michelson; M Portman; J Pikkarainen; Timo Seppälä
Drugs usage of drivers suspected of driving under the influence of alcohol and/or drugs. A study of one week's samples in 1979 and 1993 in Finland.
Forensic science international 1996;77(1-2):119-29.
1996: P Leinikki; Pirjo Lillsunde; M L Kantanen; T Korte; Timo Seppälä
[Intravenous drug abuse and the risk of HIV infections].
Duodecim; lääketieteellinen aikakauskirja 1996;112(2):150-5.
1996: Mirja Ruotsalainen; M Heikkilä; Pirjo Lillsunde; Timo Seppälä; Liisa Ahtee
Taurine infused intrastriatally elevates, but intranigrally decreases striatal extracellular dopamine concentration in anaesthetised rats.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(8-9):935-46.
1996: J Vanakoski; Juhana J. Idänpään-Heikkilä; Klaus T Olkkola; Timo Seppälä
Effects of heat exposure in a Finnish sauna on the pharmacokinetics and metabolism of midazolam.
European journal of clinical pharmacology 1996;51(3-4):335-8.
1996: Marco Mattila; A Patat; Timo Seppälä; Hely Kalska; M L Jalava; J Vanakoski; C Lavanant
Single oral doses of amisulpride do not enhance the effects of alcohol on the performance and memory of healthy subjects.
European journal of clinical pharmacology 1996;51(2):161-6.
1996: J Vanakoski; Marco Mattila; Timo Seppälä
Grapefruit juice does not enhance the effects of midazolam and triazolam in man.
European journal of clinical pharmacology 1996;50(6):501-8.
1995: Juhana J. Idänpään-Heikkilä; M Björn; Timo Seppälä
The effects of ethanol in combination with the alpha 2-adrenoceptor agonist dexmedetomidine and the alpha 2-adrenoceptor antagonist atipamezole on brain monoamine metabolites and motor performance of mice.
European journal of pharmacology 1995;292(2):191-9.
1995: J Vanakoski; Timo Seppälä
Effects of a Finnish sauna on the pharmacokinetics and haemodynamic actions of propranolol and captopril in healthy volunteers.
European journal of clinical pharmacology 1995;48(2):133-7.
1994: Juhana J. Idänpään-Heikkilä; Eija Kalso; Timo Seppälä
Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U-50,488H against noxious thermal, mechanical and inflammatory stimuli.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1306-13.
1994: Klaus T Olkkola; Katri Hamunen; Timo Seppälä; Eeva-Liisa Maunuksela
Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.
British journal of clinical pharmacology 1994;38(1):71-6.
1994: A H Bardy; Pirjo Lillsunde; Vilho Hiilesmaa; Timo Seppälä
Objectively measured perinatal exposure to meperidine and benzodiazepines in Finland.
Clinical pharmacology and therapeutics 1994;55(4):471-6.
1994: A H Bardy; Timo Seppälä; Pirjo Lillsunde; P Koskela; C G Gref
Objectively measured tobacco exposure among pregnant women in Finland in 1986 and 1990.
Acta obstetricia et gynecologica Scandinavica 1994;73(1):30-4.
1994: Reino Pöyhiä; Timo Seppälä
Liposolubility and protein binding of oxycodone in vitro.
Pharmacology & toxicology 1994;74(1):23-7.
1994: Timo Seppälä; Juhana J. Idänpään-Heikkilä; C Strömberg; Marco Mattila
Ethanol antagonism by atipamezole on motor performance in mice.
Life sciences 1994;55(3):245-51.
1993: Katri Hamunen; Eeva-Liisa Maunuksela; Timo Seppälä; Klaus T Olkkola
Pharmacokinetics of i.v. and rectal pethidine in children undergoing ophthalmic surgery.
British journal of anaesthesia 1993;71(6):823-6.
1993: A H Bardy; Timo Seppälä; Pirjo Lillsunde; J M Kataja; P Koskela; J Pikkarainen; Vilho Hiilesmaa
Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking.
British journal of obstetrics and gynaecology 1993;100(8):721-6.
1993: Katri Hamunen; Klaus T Olkkola; Timo Seppälä; Eeva-Liisa Maunuksela
Pharmacokinetics and pharmacodynamics of pentazocine in children.
Pharmacology & toxicology 1993;73(2):120-3.
1993: Arvi Yli-Hankala; Tarja Randell; Timo Seppälä; Leena Lindgren
Increases in hemodynamic variables and catecholamine levels after rapid increase in isoflurane concentration.
Anesthesiology 1993;78(2):266-71.
1993: J Vanakoski; C Strömberg; Timo Seppälä
Effects of a sauna on the pharmacokinetics and pharmacodynamics of midazolam and ephedrine in healthy young women.
European journal of clinical pharmacology 1993;45(4):377-81.
1992: Reino Pöyhiä; Timo Seppälä; Klaus T Olkkola; Eija Kalso
The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects.
British journal of clinical pharmacology 1992;33(6):617-21.
1992: C Strömberg; J Vanakoski; Klaus T Olkkola; A Lindqvist; Timo Seppälä; Lauri A Laitinen
Exercise alters the pharmacokinetics of midazolam.
Clinical pharmacology and therapeutics 1992;51(5):527-32.
1991: Reino Pöyhiä; Klaus T Olkkola; Timo Seppälä; Eija Kalso
The pharmacokinetics of oxycodone after intravenous injection in adults.
British journal of clinical pharmacology 1991;32(4):516-8.
1991: Tarja Randell; Timo Seppälä; Leena Lindgren
Isoflurane in nitrous oxide and oxygen increases plasma concentrations of noradrenaline but attenuates the pressor response to intubation.
Acta anaesthesiologica Scandinavica 1991;35(7):600-5.
1991: M L Nurminen; Ilari Paakkari; Timo Seppälä
Serotonergic involvement in the cardiovascular stimulation by thyrotropin-releasing hormone (TRH) in anesthetized rats.
Neuroscience letters 1991;127(2):147-9.
1991: A H Bardy; Timo Seppälä; T Salokorpi; Marja-Liisa Granström; P Santavuori
Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy.
Brain & development 1991;13(3):174-9.
1991: C Strömberg; A Suokas; Timo Seppälä; M Kupari
Echocardiographic and psychometric effects of amitriptyline or imipramine plus alcohol.
European journal of clinical pharmacology 1991;40(4):349-54.
1990: Eija Kalso; A Vainio; M J Mattila; Per H Rosenberg; Timo Seppälä
Morphine and oxycodone in the management of cancer pain: plasma levels determined by chemical and radioreceptor assays.
Pharmacology & toxicology 1990;67(4):322-8.
1990: T Kuitunen; Marco Mattila; Timo Seppälä; K Aranko; M E Mattila
Actions of zopiclone and carbamazepine, alone and in combination, on human skilled performance in laboratory and clinical tests.
British journal of clinical pharmacology 1990;30(3):453-61.
1989: Ulpu Saarialho-Kere; Marco Mattila; Timo Seppälä
Psychomotor, respiratory and neuroendocrinological effects of a mu-opioid receptor agonist (oxycodone) in healthy volunteers.
Pharmacology & toxicology 1989;65(4):252-7.
1988: Ulpu Saarialho-Kere; Heikki Julkunen; Marco Mattila; Timo Seppälä
Psychomotor performance of patients with rheumatoid arthritis: cross-over comparison of dextropropoxyphene, dextropropoxyphene plus amitriptyline, indomethacin, and placebo.
Pharmacology & toxicology 1988;63(4):286-92.
1988: Timo Seppälä; C Strömberg; Marco Mattila
Effects of the novel 5-hydroxytryptamine reuptake inhibitor indalpine and ethanol on psychomotor performance.
Arzneimittel-Forschung 1988;38(1):98-102.
1988: C Strömberg; A Suokas; Timo Seppälä
Interaction of alcohol with maprotiline or nomifensine: echocardiographic and psychometric effects.
European journal of clinical pharmacology 1988;35(6):593-9.
1988: Ulpu Saarialho-Kere; Marco Mattila; Timo Seppälä
Parenteral pentazocine: effects on psychomotor skills and respiration, and interactions with amitriptyline.
European journal of clinical pharmacology 1988;35(5):483-9.
1988: C Strömberg; Timo Seppälä; Marco Mattila
Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers.
Archives internationales de pharmacodynamie et de thérapie 1988;291():217-28.
1987: Ulpu Saarialho-Kere; Marco Mattila; M Paloheimo; Timo Seppälä
Psychomotor, respiratory and neuroendocrinological effects of buprenorphine and amitriptyline in healthy volunteers.
European journal of clinical pharmacology 1987;33(2):139-46.
1987: Timo Seppälä; T Ranta; R C Shrotriya
Serum prolactin levels after buspirone in man.
Medical biology 1987;65(1):61-3.
1985: K Aranko; Timo Seppälä; J Pellinen; Marco Mattila
Interaction of diazepam or lorazepam with alcohol. Psychomotor effects and bioassayed serum levels after single and repeated doses.
European journal of clinical pharmacology 1985;28(5):559-65.
1984: K Aranko; Marco Mattila; Timo Seppälä; S Aranko
The contribution of the active metabolites to the tolerance developing to diazepam in man: relationship to bioassayed serum benzodiazepine levels.
Medical biology 1984;62(5):277-84.
1983: K Aranko; Marco Mattila; Timo Seppälä
Development of tolerance and cross-tolerance to the psychomotor actions of lorazepam and diazepam in man.
British journal of clinical pharmacology 1983;15(5):545-52.
1982: Timo Seppälä; K Aranko; Marco Mattila; R C Shrotriya
Effects of alcohol on buspirone and lorazepam actions.
Clinical pharmacology and therapeutics 1982;32(2):201-7.
1980: Timo Seppälä; E Palva; Marco Mattila; K Korttila; R C Shrotriya
Tofisopam, a novel 3,4-benzodiazepine: multiple-dose effects on psychomotor skills and memory. Comparison with diazepam and interactions with ethanol.
Psychopharmacology 1980;69(2):209-18.