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Edgar Serfling

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Matthias Hock; Andris Avots; Friederike Berberich-Siebelt; Tobias Bopp; Sergei Chuvpilo; Khalid Muhammad; Amiya Kumar Patra; Duong Anh Thuy Pham; Tobias Pusch; Rene Rost; Ronald Rudolf; Edgar Schmitt; Edgar Serfling; Dimitri Tyrsin; Martin Vaeth; Stefan Klein-Hessling
NFATc1 induction in peripheral T and B lymphocytes.
Kerstin Mueller; Jasmin Quandt; Edgar Serfling; Martin Vaeth; Petra Weihrich; Thomas Wirth; Melina Claussnitzer; Katja Fiedler; Helmut Laumen; Ralf B Marienfeld; Friederike Berberich-Siebelt; Cornelia Brunner
Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.
Amiya K Patra; Thomas Schüler; Andris Avots; Ursula Bommhardt; Albert Sickmann; René P Zahedi; Edgar Serfling
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.

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All Publications

2013: Matthias Hock; Andris Avots; Friederike Berberich-Siebelt; Tobias Bopp; Sergei Chuvpilo; Khalid Muhammad; Amiya Kumar Patra; Duong Anh Thuy Pham; Tobias Pusch; Rene Rost; Ronald Rudolf; Edgar Schmitt; Edgar Serfling; Dimitri Tyrsin; Martin Vaeth; Stefan Klein-Hessling
NFATc1 induction in peripheral T and B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2345-53.
2013: Kerstin Mueller; Jasmin Quandt; Edgar Serfling; Martin Vaeth; Petra Weihrich; Thomas Wirth; Melina Claussnitzer; Katja Fiedler; Helmut Laumen; Ralf B Marienfeld; Friederike Berberich-Siebelt; Cornelia Brunner
Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.
Nucleic acids research 2013;41(4):2138-54.
2013: Amiya K Patra; Thomas Schüler; Andris Avots; Ursula Bommhardt; Albert Sickmann; René P Zahedi; Edgar Serfling
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.
Nature immunology 2013;14(2):127-35.
2012: Martin Vaeth; Ari Waisman; Helmut Jonuleit; Gerd Müller; Martin R Müller; Sonja Reissig; Kazuki Satoh; Birgit S Sawitzki; Ulrike Schliesser; Edgar Serfling; Andrea Tuettenberg; Friederike Berberich-Siebelt
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16258-63.
2012: Josef Bodor; Christian Becker; Thomas Hünig; Matthias Klein; Hansjörg Schild; Edgar Serfling; Martin Vaeth; Christian Becker; Edgar Schmitt
Cyclic AMP underpins suppression by regulatory T cells.
European journal of immunology 2012;42(6):1375-84.
2012: Thomas F Benkert; Mathias Buttmann; Lena Dietz; Elena M Hartmann; Ellen Leich; Andreas Rosenwald; Edgar Serfling; Friederike Berberich-Siebelt
Natalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis.
PloS one 2012;7(12):e52208.
2012: Edgar Serfling; Martin Vaeth; Andris Avots; Stefan Klein-Hessling; Ronald Rudolf; Friederike Berberich-Siebelt
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes.
Cell communication and signaling : CCS 2012;10(1):16.
2011: Sankar Bhattacharyya; Jolly Deb; Amiya K Patra; Duong Anh Thuy Pham; Wen Chen; Martin Vaeth; Friederike Berberich-Siebelt; Stefan Klein-Hessling; Edward D Lamperti; Kurt Reifenberg; Julia Jellusova; Astrid Schweizer; Lars Nitschke; Ellen Leich; Andreas Rosenwald; Cornelia Brunner; Swen Engelmann; Ursula Bommhardt; Andris Avots; Martin R Müller; Eisaku Kondo; Edgar Serfling
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
The Journal of experimental medicine 2011;208(4):823-39.
2011: Friederike Berberich-Siebelt; Andris Avots; Edgar Serfling
Transcriptional programming in the immune system: report on the International Workshop of the Transregio TR52, November 17-20, 2010 in Würzburg, Germany.
European journal of immunology 2011;41(4):885-8.
2011: Martin Vaeth; Tea Gogishvili; Tobias Bopp; Matthias Klein; Friederike Berberich-Siebelt; Stefan Gattenloehner; Andris Avots; Tim D. Sparwasser; Nadine Grebe; Edgar Schmitt; Thomas Hünig; Edgar Serfling; Josef Bodor
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2480-5.
2009: Arnab Nayak; Judith Glöckner-Pagel; Martin Vaeth; Julia E Schumann; Mathias Buttmann; Tobias Bopp; Edgar Schmitt; Edgar Serfling; Friederike Berberich-Siebelt
Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.
The Journal of biological chemistry 2009;284(16):10935-46.
2009: Stefan Gattenlöhner; Thorsten Stühmer; Ellen Leich; Matthias Reinhard; Benjamin Etschmann; Hans-Ullrich Völker; Andreas Rosenwald; Edgar Serfling; Ralf C Bargou; Georg Ertl; Hermann Einsele; Hans Konrad Müller-Hermelink
Specific detection of CD56 (NCAM) isoforms for the identification of aggressive malignant neoplasms with progressive development.
The American journal of pathology 2009;174(4):1160-71.
2008: Stefan Klein-Hessling; Tobias Bopp; Mithilesh Kumar Jha; Arthur Schmidt; Shoichiro Miyatake; Edgar Schmitt; Edgar Serfling
Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter.
The Journal of biological chemistry 2008;283(45):31030-7.
2008: Askar Akimzhanov; Laszlo Krenacs; Timm Schlegel; Stefan Klein-Hessling; Enikö Bagdi; Eva Stelkovics; Eisaku Kondo; Sergei Chuvpilo; Philipp Wilke; Andris Avots; Stefan Gattenlöhner; Hans Konrad Müller-Hermelink; Alois Palmetshofer; Edgar Serfling
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling.
The American journal of pathology 2008;172(1):215-24.
2007: Stefan Gattenloehner; Sergei Chuvpilo; Claudia Langebrake; Dirk Reinhardt; Hans Konrad Müller-Hermelink; Edgar Serfling; Angela Vincent; Alexander Marx
Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression.
Blood 2007;110(6):2027-33.
2007: Matthias Sieber; Magdalena Karanik; Claudia Brandt; Christian Blex; Miriam Podtschaske; Frank Erdmann; Rene Rost; Edgar Serfling; Jürgen Liebscher; Michael Pätzel; Andreas Radbruch; Gunter Fischer; Ria Baumgrass
Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3.
European journal of immunology 2007;37(9):2617-26.
2007: Edgar Serfling; Friederike Berberich-Siebelt; Andris Avots
NFAT in lymphocytes: a factor for all events?
Science's STKE : signal transduction knowledge environment 2007;2007(398):pe42.
2007: Roza I Nurieva; Sergei Chuvpilo; Eric Wieder; Keith B Elkon; Richard M Locksley; Edgar Serfling; Chen Dong
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1096-103.
2007: Tobias Bopp; Christian Becker; Matthias Klein; Stefan Klein-Hessling; Alois Palmetshofer; Edgar Serfling; Valeska Heib; Marc Becker; Jan Kubach; Steffen Schmitt; Sabine Stoll; Hansjörg Schild; Martin Staege; Michael Stassen; Helmut Jonuleit; Edgar Schmitt
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.
The Journal of experimental medicine 2007;204(6):1303-10.
2007: Stefan Floess; Jennifer Freyer; Christiane Siewert; Udo Baron; Sven Olek; Julia Polansky; Kerstin Schlawe; Hyun-Dong Chang; Tobias Bopp; Edgar Schmitt; Stefan Klein-Hessling; Edgar Serfling; Alf Hamann; Jochen Huehn
Epigenetic control of the foxp3 locus in regulatory T cells.
PLoS biology 2007;5(2):e38.
2007: Michael Stassen; Matthias Klein; Marc Becker; Tobias Bopp; Christine Neudörfl; Christoph Richter; Valeska Heib; Stefan Klein-Hessling; Edgar Serfling; Hansjörg Schild; Edgar Schmitt
p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1.
Molecular immunology 2007;44(5):926-33.
2007: Mathias Buttmann; Friederike Berberich-Siebelt; Edgar Serfling; Peter Rieckmann
Interferon-beta is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells.
Journal of vascular research 2007;44(1):51-60.
2006: Matthias Klein; Stefan Klein-Hessling; Alois Palmetshofer; Edgar Serfling; Christine Tertilt; Tobias Bopp; Valeska Heib; Marc Becker; Christian Taube; Hansjörg Schild; Edgar Schmitt; Michael Stassen
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6667-74.
2006: Edgar Serfling; Stefan Klein-Hessling; Alois Palmetshofer; Tobias Bopp; Michael Stassen; Edgar Schmitt
NFAT transcription factors in control of peripheral T cell tolerance.
European journal of immunology 2006;36(11):2837-43.
2006: Amiya K Patra; Thomas Drewes; Swen Engelmann; Sergei Chuvpilo; Hiroyuki Kishi; Thomas Hünig; Edgar Serfling; Ursula Bommhardt
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4567-76.
2006: Edgar Serfling; Sergei Chuvpilo; Jiming Liu; Thomas Höfer; Alois Palmetshofer
NFATc1 autoregulation: a crucial step for cell-fate determination.
Trends in immunology 2006;27(10):461-9.
2006: Friederike Berberich-Siebelt; Ingolf Berberich; Mindaugas Andrulis; Brigitte Santner-Nanan; Mithilesh Kumar Jha; Stefan Klein-Hessling; Anneliese Schimpl; Edgar Serfling
SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4843-51.
2005: Sys Zoffmann Glud; Annette Balle Sørensen; Mindaugas Andrulis; Bruce Wang; Eisaku Kondo; Randi Jessen; Laszlo Krenacs; Eva Stelkovics; Matthias Wabl; Edgar Serfling; Alois Palmetshofer; Finn Skou Pedersen
A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.
Blood 2005;106(10):3546-52.
2005: Masataka Asagiri; kojiro sato; Takako Usami; Sae Ochi; Hiroshi Nishina; Hiroki Yoshida; Ikuo Morita; Erwin F Wagner; Tak W Mak; Edgar Serfling; Hiroshi Takayanagi
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
The Journal of experimental medicine 2005;202(9):1261-9.
2005: Devapriya Nandini Samanta; Alois Palmetshofer; Dragan Marinkovic; Thomas Wirth; Edgar Serfling; Lars Nitschke
B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4797-802.
2005: Tobias Bopp; Alois Palmetshofer; Edgar Serfling; Valeska Heib; Steffen Schmitt; Christoph Richter; Matthias Klein; Hansjörg Schild; Edgar Schmitt; Michael Stassen
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells.
The Journal of experimental medicine 2005;201(2):181-7.
2004: Edgar Serfling; Friederike Berberich-Siebelt; Andris Avots; Sergei Chuvpilo; Stefan Klein-Hessling; Mithilesh Kumar Jha; Eizaku Kondo; Philipp Pagel; Jan Schulze-Luehrmann; Alois Palmetshofer
NFAT and NF-kappaB factors-the distant relatives.
The international journal of biochemistry & cell biology 2004;36(7):1166-70.
2004: A Meyer-Bahlburg; S Greil; Niels Kruse; Ralf B Marienfeld; Edgar Serfling; HI Huppertz
Yersinia enterocolitica leads to transient induction of TNF-alpha and activates NF-kappaB in synovial fibroblasts.
Clinical and experimental rheumatology 2004;22(3):278-84.
2003: Klaus J Erb; Thomas Twardzik; Alois Palmetshofer; Gisela Wohlleben; Ursula Tatsch; Edgar Serfling
Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infection.
Infection and immunity 2003;71(11):6641-7.
2003: Ralf B Marienfeld; Michael May; Ingolf Berberich; Edgar Serfling; Sankar Ghosh; Manfred Neumann
RelB forms transcriptionally inactive complexes with RelA/p65.
The Journal of biological chemistry 2003;278(22):19852-60.
2003: Stefan Klein-Hessling; Mithilesh Kumar Jha; Brigitte Santner-Nanan; Friederike Berberich-Siebelt; Thomas Baumruker; Anneliese Schimpl; Edgar Serfling
Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2956-61.
2003: Martin Leverkus; Martin Sprick; Tina Wachter; Thilo Mengling; Bernd Baumann; Edgar Serfling; Eva-B Bröcker; Matthias Goebeler; Manfred Neumann; Henning Walczak
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation.
Molecular and cellular biology 2003;23(3):777-90.
2003: Nadezhda Romanchikova; Victorija Ivanova; Carsten Scheller; Eriks Jankevics; Christian Jassoy; Edgar Serfling
NFAT transcription factors control HIV-1 expression through a binding site downstream of TAR region.
Immunobiology 2003;208(4):361-5.
2002: Christian Kneitz; Martin Goller; Hans-Peter Tony; Andreas Simon; Corinne Stibbe; Thomas König; Edgar Serfling; Andris Avots
The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.
Biochimica et biophysica acta 2002;1588(1):41-7.
2002: Cornelia Brunner; Andris Avots; Hans Wolfgang Kreth; Edgar Serfling; Volker Schuster
Bruton's tyrosine kinase is activated upon CD40 stimulation in human B lymphocytes.
Immunobiology 2002;206(4):432-40.
2002: Jan Schulze-Luehrmann; Brigitte Santner-Nanan; Mithilesh Kumar Jha; Anneliese Schimpl; Andris Avots; Edgar Serfling
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes.
Blood 2002;100(3):954-60.
2002: Sean A Diehl; Chi-Wing Chow; Linda Weiss; Alois Palmetshofer; Thomas Twardzik; Laura Rounds; Edgar Serfling; Roger J Davis; Juan Anguita; Mercedes Rincón
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.
The Journal of experimental medicine 2002;196(1):39-49.
2002: Sergei Chuvpilo; Eriks Jankevics; Dimitri Tyrsin; Askar Akimzhanov; Denis Moroz; Mithilesh Kumar Jha; Jan Schulze-Luehrmann; Brigitte Santner-Nanan; Elizaveta Feoktistova; Thomas König; Andris Avots; Edgar Schmitt; Friederike Berberich-Siebelt; Anneliese Schimpl; Edgar Serfling
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.
Immunity 2002;16(6):881-95.
2001: Ralf B Marienfeld; Friederike Berberich-Siebelt; Ingolf Berberich; Andrea Denk; Edgar Serfling; Manfred Neumann
Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control.
Oncogene 2001;20(56):8142-7.
2001: Michael Stassen; Christian Müller; M Arnold; Lothar Hültner; Stefan Klein-Hessling; Christine Neudörfl; T Reineke; Edgar Serfling; Edgar Schmitt
IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4391-8.
2000: Edgar Serfling; Friederike Berberich-Siebelt; Sergei Chuvpilo; Eriks Jankevics; Stefan Klein-Hessling; Thomas Twardzik; Andris Avots
The role of NF-AT transcription factors in T cell activation and differentiation.
Biochimica et biophysica acta 2000;1498(1):1-18.
2000: Friederike Berberich-Siebelt; Stefan Klein-Hessling; N Hepping; Brigitte Santner-Nanan; D Lindemann; Anneliese Schimpl; Ingolf Berberich; Edgar Serfling
C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells.
European journal of immunology 2000;30(9):2576-85.
2000: Heike Bömmel; M Li-Weber; Edgar Serfling; Albert Duschl
The environmental pollutant pyrene induces the production of IL-4.
The Journal of allergy and clinical immunology 2000;105(4):796-802.
2000: Christian Kneitz; Martin Goller; Ruth Seggewiss; A Yaman; Edgar Serfling; Hans-Peter Tony
STAT6 and the regulation of CD23 expression in B-chronic lymphocytic leukemia.
Leukemia research 2000;24(4):331-7.
2000: Manfred Neumann; HW Fries; C Scheicher; Petra Keikavoussi; Annette Kolb-Mäurer; Eva-B Bröcker; Edgar Serfling; Eckhart Kämpgen
Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells.
Blood 2000;95(1):277-85.
1999: Narendra Chirmule; Andris Avots; S M LakshmiTamma; Savita Pahwa; Edgar Serfling
CD4-mediated signals induce T cell dysfunction in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):644-9.
1999: Sergei Chuvpilo; Andris Avots; Friederike Berberich-Siebelt; J Glöckner; C Fischer; Andreas Kerstan; C Escher; I Inashkina; Falk Hlubek; Eriks Jankevics; T Brabletz; Edgar Serfling
Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7294-301.
1999: Andris Avots; Mathias Buttmann; Sergei Chuvpilo; C Escher; U Smola; A J Bannister; Ulf R Rapp; T Kouzarides; Edgar Serfling
CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.
Immunity 1999;10(5):515-24.
1999: Norbert Bannert; Andris Avots; M Baier; Edgar Serfling; Reinhard Kurth
GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1541-6.
1999: Sergei Chuvpilo; M Zimmer; Andreas Kerstan; J Glöckner; Andris Avots; C Escher; C Fischer; I Inashkina; Eriks Jankevics; Friederike Berberich-Siebelt; Edgar Schmitt; Edgar Serfling
Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.
Immunity 1999;10(2):261-9.
1998: Kai Schuh; Thomas Twardzik; Burkhard Kneitz; Joerg Heyer; Anneliese Schimpl; Edgar Serfling
The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells.
The Journal of experimental medicine 1998;188(7):1369-73.
1998: R Siefken; Stefan Klein-Hessling; Edgar Serfling; R Kurrle; Reinhard Schwinzer
A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1645-51.
1998: Kai Schuh; Burkhard Kneitz; Joerg Heyer; Ursula Bommhardt; Eriks Jankevics; Friederike Berberich-Siebelt; K Pfeffer; Hans Konrad Müller-Hermelink; Anneliese Schimpl; Edgar Serfling
Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice.
European journal of immunology 1998;28(8):2456-66.
1998: A Hoffmeyer; Andris Avots; Egbert Flory; Christoph K Weber; Edgar Serfling; Ulf R Rapp
The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes.
The Journal of biological chemistry 1998;273(17):10112-9.
1997: Joerg Heyer; Burkhard Kneitz; Kai Schuh; Eriks Jankevics; F Siebelt; Anneliese Schimpl; Edgar Serfling
Inefficient termination of antigen responses in NF-ATp-deficient mice.
Immunobiology 1997;198(1-3):162-9.
1997: F Siebelt; Ingolf Berberich; G Shu; Edgar Serfling; E A Clark
Role for CD40-mediated activation of c-Rel and maintenance of c-myc RNA levels in mitigating anti-IgM-induced growth arrest.
Cellular immunology 1997;181(1):13-22.
1997: Andris Avots; A Hoffmeyer; Egbert Flory; A Cimanis; Ulf R Rapp; Edgar Serfling
GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
Molecular and cellular biology 1997;17(8):4381-9.
1997: Ralf B Marienfeld; Manfred Neumann; Sergei Chuvpilo; C Escher; Burkhard Kneitz; Andris Avots; Anneliese Schimpl; Edgar Serfling
Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells.
European journal of immunology 1997;27(7):1601-9.
1997: Kai Schuh; Burkhard Kneitz; Joerg Heyer; F Siebelt; C Fischer; Eriks Jankevics; E Rüde; Edgar Schmitt; Anneliese Schimpl; Edgar Serfling
NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines.
Immunology letters 1997;57(1-3):171-5.
1996: S Klein-Hessling; G Schneider; A Heinfling; Sergei Chuvpilo; Edgar Serfling
HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15311-6.
1996: Manfred Neumann; Gisela Wohlleben; Sergei Chuvpilo; B Kistler; Thomas Wirth; Edgar Serfling; Anneliese Schimpl
CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):4862-9.
1996: Kai Schuh; Andris Avots; Hans-Peter Tony; Edgar Serfling; C Kneitz
Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients.
Leukemia & lymphoma 1996;23(5-6):583-92.
1996: Manfred Neumann; A Wilisch; B C Ma; Brian J Druker; Edgar Serfling; B R Franza
BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells.
Anticancer research 1996;16(3A):1075-83.
1995: Edgar Serfling; Andris Avots; Manfred Neumann
The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation.
Biochimica et biophysica acta 1995;1263(3):181-200.
1995: A Mouzaki; Edgar Serfling; Rudolf H Zubler
Interleukin-2 promoter activity in Epstein-Barr virus-transformed B lymphocytes is controlled by nuclear factor-chi B.
European journal of immunology 1995;25(8):2177-82.
1995: G Schneider; A Heinfling; S Klein-Hessling; C Schomberg; Sergei Chuvpilo; Edgar Serfling
The inducible transcription factor NF-AT plays an important role in the activation of the murine interleukin-4 promoter.
Immunobiology 1995;193(2-4):268-72.
1995: Andris Avots; C Escher; SM Müller-Deubert; Manfred Neumann; Edgar Serfling
The interplay between lymphoid-specific and ubiquitous transcription factors controls the expression of interleukin 2 gene in T lymphocytes.
Immunobiology 1995;193(2-4):254-8.
1995: Manfred Neumann; T Grieshammer; Sergei Chuvpilo; Burkhard Kneitz; Michael Lohoff; Anneliese Schimpl; B R Franza; Edgar Serfling
RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.
The EMBO journal 1995;14(9):1991-2004.
1994: I Pfeuffer; S Klein-Hessling; A Heinfling; Sergei Chuvpilo; C Escher; Thomas Brabletz; B Hentsch; H Schwarzenbach; Patrick Matthias; Edgar Serfling
Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5572-85.
1994: N Hauf; Werner Goebel; Edgar Serfling; Michael Kuhn
Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells.
Infection and immunity 1994;62(7):2740-7.
1993: Sergei Chuvpilo; C Schomberg; R Gerwig; A Heinfling; R Reeves; Friedrich Grummt; Edgar Serfling
Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter.
Nucleic acids research 1993;21(24):5694-704.
1993: Thomas Brabletz; I Pfeuffer; E Schorr; F Siebelt; Thomas Wirth; Edgar Serfling
Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site.
Molecular and cellular biology 1993;13(2):1155-62.
1992: B Hentsch; A Mouzaki; I Pfeuffer; D Rungger; Edgar Serfling
The weak, fine-tuned binding of ubiquitous transcription factors to the Il-2 enhancer contributes to its T cell-restricted activity.
Nucleic acids research 1992;20(11):2657-65.
1991: Karoline J Briegel; B Hentsch; I Pfeuffer; Edgar Serfling
One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.
Nucleic acids research 1991;19(21):5929-36.
1991: B Maurer; Edgar Serfling; Volker ter Meulen; Axel Rethwilm
Transcription factor AP-1 modulates the activity of the human foamy virus long terminal repeat.
Journal of virology 1991;65(11):6353-7.
1991: Thomas Brabletz; I Pietrowski; Edgar Serfling
The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer.
Nucleic acids research 1991;19(1):61-7.
1990: C Randak; Thomas Brabletz; M Hergenröther; I Sobotta; Edgar Serfling
Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.
The EMBO journal 1990;9(8):2529-36.
1990: A Radler-Pohl; I Pfeuffer; Michael Karin; Edgar Serfling
A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.
The New biologist 1990;2(6):566-73.
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