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Louise Serpell

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Publications

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Kyle L Morris; Alison Rodger; Frederic Rousseau; Joost Schymkowitz; Maya Debulpaep; Matthew R Hicks; Louise C Serpell
Exploring the sequence-structure relationship for amyloid peptides.
Kyle L Morris; Lin Chen; Michel Goedert; Pawel Sikorski; Shahin Zibaee; Louise C Serpell
The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1.
Kyle L Morris; Louise C Serpell
X-ray fibre diffraction studies of amyloid fibrils.

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All Publications

2013: Kyle L Morris; Alison Rodger; Frederic Rousseau; Joost Schymkowitz; Maya Debulpaep; Matthew R Hicks; Louise C Serpell
Exploring the sequence-structure relationship for amyloid peptides.
The Biochemical journal 2013;450(2):275-83.
2013: Kyle L Morris; Lin Chen; Michel Goedert; Pawel Sikorski; Shahin Zibaee; Louise C Serpell
The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1.
Angewandte Chemie (International ed. in English) 2013;52(8):2279-83.
2012: Kyle L Morris; Louise C Serpell
X-ray fibre diffraction studies of amyloid fibrils.
Methods in molecular biology (Clifton, N.J.) 2012;849():121-35.
2011: Thomas L Williams; Louise C Serpell
Membrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity.
The FEBS journal 2011;278(20):3905-17.
2011: Thomas L Williams; Brigita Urbanc; Simon D A Connell; A Toby A Jenkins; Benjamin R G Johnson; Louise C Serpell
Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes.
The Biochemical journal 2011;439(1):67-77.
2011: Karen E Marshall; Kyle L Morris; Deborah Charlton; Nicola O'Reilly; Laurence Lewis; Helen Walden; Louise C Serpell
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability.
Biochemistry 2011;50(12):2061-71.
2011: Beinan Liu; Aileen Moloney; Sarah Meehan; Kyle Morris; Sally E Thomas; Louise C Serpell; Robert Hider; Stefan Marciniak; David A Lomas; Damian C Crowther
Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.
The Journal of biological chemistry 2011;286(6):4248-56.
2010: Shahin Zibaee; Graham Fraser; Ross Jakes; David Owen; Louise C Serpell; R Anthony Crowther; Michel Goedert
Human beta-synuclein rendered fibrillogenic by designed mutations.
The Journal of biological chemistry 2010;285(49):38555-67.
2010: Thomas L Williams; Iain J Day; Louise C Serpell
The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles.
Langmuir : the ACS journal of surfaces and colloids 2010;26(22):17260-8.
2010: Thomas R Jahn; O Sumner Makin; Kyle L Morris; Karen E Marshall; Pei Tian; Pawel Sikorski; Louise C Serpell
The common architecture of cross-beta amyloid.
Journal of molecular biology 2010;395(4):717-27.
2010: Karen E Marshall; Matthew R Hicks; Thomas L Williams; Søren Vrønning Hoffmann; Alison Rodger; Timothy R Dafforn; Louise C Serpell
Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.
Biophysical journal 2010;98(2):330-8.
2009: Benjamin M Bulheller; Alison Rodger; Matthew R Hicks; Timothy R Dafforn; Louise C Serpell; Karen E Marshall; Elizabeth H C Bromley; Patrick J S King; Kevin J Channon; Derek N Woolfson; Jonathan D Hirst
Flow linear dichroism of some prototypical proteins.
Journal of the American Chemical Society 2009;131(37):13305-14.
2009: Karen E Marshall; Louise C Serpell
Structural integrity of beta-sheet assembly.
Biochemical Society transactions 2009;37(Pt 4):671-6.
2009: Eleanor F Banwell; Edgardo Abelardo; Dave J Adams; Martin A Birchall; Adam Corrigan; Athene M Donald; Mark Kirkland; Louise C Serpell; Michael F Butler; Derek N Woolfson
Rational design and application of responsive alpha-helical peptide hydrogels.
Nature materials 2009;8(7):596-600.
2008: Roma N Rambaran; Louise C Serpell
Amyloid fibrils: abnormal protein assembly.
Prion 2008;2(3):112-7.
2008: Michel O Steinmetz; Zrinka Gattin; rene verel; Barbara Ciani; Thusnelda Stromer; Janelle M Green; Peter Tittmann; Clemens Schulze-Briese; Heinz Gross; Wilfred F van Gunsteren; Beat H Meier; Louise C Serpell; Shirley A Müller; Richard A Kammerer
Atomic models of de novo designed cc beta-Met amyloid-like fibrils.
Journal of molecular biology 2008;376(3):898-912.
2007: Shahin Zibaee; Ross Jakes; Graham Fraser; Louise C Serpell; R Anthony Crowther; Michel Goedert
Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.
Journal of molecular biology 2007;374(2):454-64.
2007: Louise C Serpell; Merrill Benson; Juris J Liepnieks; Paul E Fraser
Structural analyses of fibrinogen amyloid fibrils.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2007;14(3):199-203.
2007: David Papapostolou; Andrew M Smith; Edward D T Atkins; Seb J Oliver; Maxim G Ryadnov; Louise C Serpell; Derek N Woolfson
Engineering nanoscale order into a designed protein fiber.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10853-8.
2007: Shahin Zibaee; O Sumner Makin; Michel Goedert; Louise C Serpell
A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone.
Protein science : a publication of the Protein Society 2007;16(5):906-18.
2007: Ute Slotta; Simone Hess; Kristina Spiess; Thusnelda Stromer; Louise C Serpell; Thomas Scheibel
Spider silk and amyloid fibrils: a structural comparison.
Macromolecular bioscience 2007;7(2):183-8.
2006: Peter Stanley; Louise C Serpell; Penelope E Stein
Polymerization of human angiotensinogen: insights into its structural mechanism and functional significance.
The Biochemical journal 2006;400(1):169-78.
2006: Neil A Ranson; Thusnelda Stromer; Luc Bousset; Ronald Melki; Louise C Serpell
Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils.
Protein science : a publication of the Protein Society 2006;15(11):2481-7.
2006: O Sumner Makin; Pawel Sikorski; Louise C Serpell
Diffraction to study protein and peptide assemblies.
Current opinion in chemical biology 2006;10(5):417-22.
2006: Wei Li; Louise C Serpell; Wendy J Carter; David C Rubinsztein; James A Huntington
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein.
The Journal of biological chemistry 2006;281(23):15916-22.
2006: Hirotaka Yoshida; Molly Craxton; Ross Jakes; Shahin Zibaee; Richard Tavaré; Graham Fraser; Louise C Serpell; Bazbek Davletov; R Anthony Crowther; Michel Goedert
Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization.
Biochemistry 2006;45(8):2599-607.
2005: O Sumner Makin; Louise C Serpell
Structures for amyloid fibrils.
The FEBS journal 2005;272(23):5950-61.
2005: Thusnelda Stromer; Louise C Serpell
Structure and morphology of the Alzheimer's amyloid fibril.
Microscopy research and technique 2005;67(3-4):210-7.
2005: O Sumner Makin; Edward D T Atkins; Pawel Sikorski; Jan Johansson; Louise C Serpell
Molecular basis for amyloid fibril formation and stability.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):315-20.
2005: O Sumner Makin; Louise C Serpell
X-ray diffraction studies of amyloid structure.
Methods in molecular biology (Clifton, N.J.) 2005;299():67-80.
2004: Woong Choi; Shahin Zibaee; Ross Jakes; Louise C Serpell; Bazbek Davletov; R Anthony Crowther; Michel Goedert
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.
FEBS letters 2004;576(3):363-8.
2004: O Sumner Makin; Louise C Serpell
Structural characterisation of islet amyloid polypeptide fibrils.
Journal of molecular biology 2004;335(5):1279-88.
2004: Timothy R Dafforn; Jascindra Rajendra; Halsall David; Louise C Serpell; Alison Rodger
Protein fiber linear dichroism for structure determination and kinetics in a low-volume, low-wavelength couette flow cell.
Biophysical journal 2004;86(1 Pt 1):404-10.
2003: Pawel Sikorski; Edward D T Atkins; Louise C Serpell
Structure and texture of fibrous crystals formed by Alzheimer's abeta(11-25) peptide fragment.
Structure (London, England : 1993) 2003;11(8):915-26.
2003: David P Smith; Susan Jones; Louise C Serpell; Margaret Sunde; Sheena E Radford
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation.
Journal of molecular biology 2003;330(5):943-54.
2003: John Berriman; Louise C Serpell; Keith A Oberg; Anthony L Fink; Michel Goedert; R Anthony Crowther
Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):9034-8.
2003: Damian C Crowther; Louise C Serpell; Timothy R Dafforn; Bibek Gooptu; David A Lomas
Nucleation of alpha 1-antichymotrypsin polymerization.
Biochemistry 2003;42(8):2355-63.
2002: Della C David; Robert Layfield; Louise C Serpell; Yolanda Narain; Michel Goedert; Maria Grazia Spillantini
Proteasomal degradation of tau protein.
Journal of neurochemistry 2002;83(1):176-85.
2002: O Sumner Makin; Louise C Serpell
Examining the structure of the mature amyloid fibril.
Biochemical Society transactions 2002;30(4):521-5.
2002: Dean J Derbyshire; Balaku P Basu; Louise C Serpell; Woo S Joo; Takayasu Date; Kuniyoshi Iwabuchi; Aidan J Doherty
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.
The EMBO journal 2002;21(14):3863-72.
2001: Michel Goedert; Maria Grazia Spillantini; Louise C Serpell; John Berriman; MJ Smith; Ross Jakes; R Anthony Crowther
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):213-27.
2000: Louise C Serpell; CC Blake; Paul E Fraser
Molecular structure of a fibrillar Alzheimer's A beta fragment.
Biochemistry 2000;39(43):13269-75.
2000: Louise C Serpell; Margaret Sunde; M D Benson; G A Tennent; Mark B Pepys; Paul E Fraser
The protofilament substructure of amyloid fibrils.
Journal of molecular biology 2000;300(5):1033-9.
2000: H A Lashuel; Louise C Serpell; L Woo; S R Labrenz; Jeffery W Kelly
Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science.
Journal of the American Chemical Society 2000;122(22):5262-77.
2000: Louise C Serpell; J M Smith
Direct visualisation of the beta-sheet structure of synthetic Alzheimer's amyloid.
Journal of molecular biology 2000;299(1):225-31.
2000: Louise C Serpell; John Berriman; Ross Jakes; Michel Goedert; R Anthony Crowther
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4897-902.
1999: Louise C Serpell; Paul E Fraser; Margaret Sunde
X-ray fiber diffraction of amyloid fibrils.
Methods in enzymology 1999;309():526-36.
1997: Louise C Serpell; Margaret Sunde; CC Blake
The molecular basis of amyloidosis.
Cellular and molecular life sciences : CMLS 1997;53(11-12):871-87.
1997: Margaret Sunde; Louise C Serpell; Mark Bartlam; Paul E Fraser; Mark B Pepys; CC Blake
Common core structure of amyloid fibrils by synchrotron X-ray diffraction.
Journal of molecular biology 1997;273(3):729-39.
1996: C Blake; Louise C Serpell
Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous beta-sheet helix.
Structure (London, England : 1993) 1996;4(8):989-98.
1996: AJ Doherty; Louise C Serpell; C P Ponting
The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.
Nucleic acids research 1996;24(13):2488-97.
1996: Mark B Pepys; Glenys A Tennent; David R Booth; Vittorio Bellotti; Laurence Bruce Lovat; S Y Tan; MR Persey; Winston L Hutchinson; Susanne E Booth; S Madhoo; Anne K Soutar; Philip N Hawkins; R Van Zyl-Smit; J M Campistol; Paul E Fraser; S E Radford; Carol V Robinson; Margaret Sunde; Louise C Serpell; CC Blake
Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy.
Ciba Foundation symposium 1996;199():73-81; discussion 81-9.
1996: CC Blake; Louise C Serpell; Margaret Sunde; O Sandgren; E Lundgren
A molecular model of the amyloid fibril.
Ciba Foundation symposium 1996;199():6-15; discussion 15-21, 40-6.
1995: Louise C Serpell; Margaret Sunde; Paul E Fraser; Pradeep Luther; Edward P Morris; O Sangren; E Lundgren; CC Blake
Examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs.
Journal of molecular biology 1995;254(2):113-8.