Raquel Seruca

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Ferreira Ana Monteiro; Westers Helga; Albergaria André; Seruca Raquel; Hofstra Robert M W
Estrogens, MSI and Lynch syndrome-associated tumors.
Borie Claire; Colas Chrystelle; Dartigues Peggy; Lazure Thierry; Rince Patricia; Buhard Olivier; Folliot Patrick; Chalastanis Alexandra; Muleris Martine; Hamelin Richard; Mercier Dominique; Oliveira Carla; Seruca Raquel; Chadburn Amy; Leblond Véronique; Barete Stéphane; Gaïdano Gianluca; Martin Antoine; Gaulard Philippe; Fléjou Jean-François; Raphael Martine; Duval Alex
The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.
Viana-Pereira Marta; Almeida Inês; Sousa Sónia; Mahler-Araújo Bethânia; Seruca Raquel; Pimentel José; Reis Rui Manuel
Analysis of microsatellite instability in medulloblastoma.

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All Publications

2009: Ferreira Ana Monteiro; Westers Helga; Albergaria André; Seruca Raquel; Hofstra Robert M W
Estrogens, MSI and Lynch syndrome-associated tumors.
Biochimica et biophysica acta 2009;1796(2):194-200.
2009: Borie Claire; Colas Chrystelle; Dartigues Peggy; Lazure Thierry; Rince Patricia; Buhard Olivier; Folliot Patrick; Chalastanis Alexandra; Muleris Martine; Hamelin Richard; Mercier Dominique; Oliveira Carla; Seruca Raquel; Chadburn Amy; Leblond Véronique; Barete Stéphane; Gaïdano Gianluca; Martin Antoine; Gaulard Philippe; Fléjou Jean-François; Raphael Martine; Duval Alex
The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.
International journal of cancer. Journal international du cancer 2009;125(10):2360-6.
2009: Viana-Pereira Marta; Almeida Inês; Sousa Sónia; Mahler-Araújo Bethânia; Seruca Raquel; Pimentel José; Reis Rui Manuel
Analysis of microsatellite instability in medulloblastoma.
Neuro-oncology 2009;11(5):458-67.
2009: Oliveira Maria Jose; Costa Angela Margarida; Costa Ana Catarina; Ferreira Rui Manuel; Sampaio Paula; Machado Jose Carlos; Seruca Raquel; Mareel Marc; Figueiredo Ceu
CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype.
The Journal of infectious diseases 2009;200(5):745-55.
2009: Ferreira Ana M; Westers Helga; Sousa Sónia; Wu Ying; Niessen Renée C; Olderode-Berends Maran; van der Sluis Tineke; Reuvekamp Peter T W; Seruca Raquel; Kleibeuker Jan H; Hollema Harry; Sijmons Rolf H; Hofstra Robert M W
Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients.
The Journal of pathology 2009;219(1):96-102.
2009: Xavier Cristina P R; Lima Cristovao F; Preto Ana; Seruca Raquel; Fernandes-Ferreira Manuel; Pereira-Wilson Cristina
Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.
Cancer letters 2009;281(2):162-70.
2009: Pinho Salomé S; Reis Celso A; Paredes Joana; Magalhães Ana Maria; Ferreira António Carlos; Figueiredo Joana; Xiaogang Wen; Carneiro Fátima; Gärtner Fátima; Seruca Raquel
The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.
Human molecular genetics 2009;18(14):2599-608.
2009: Oliveira Carla; Sousa Sónia; Pinheiro Hugo; Karam Rachid; Bordeira-Carriço Renata; Senz Janine; Kaurah Pardeep; Carvalho Joana; Pereira Rui; Gusmão Leonor; Wen Xiaogang; Cipriano Maria Augusta; Yokota Jun; Carneiro Fátima; Huntsman David; Seruca Raquel
Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression.
Gastroenterology 2009;136(7):2137-48.
2009: Machado Ana Manuel Dantas; Figueiredo Ceu; Touati Eliette; Máximo Valdemar; Sousa Sonia; Michel Valérie; Carneiro Fátima; Nielsen Finn Cilius; Seruca Raquel; Rasmussen Lene Juel
Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(9):2995-3002.
2009: Mateus Ana Rita; Simões-Correia Joana; Figueiredo Joana; Heindl Stefan; Alves Catarina Castro; Suriano Gianpaolo; Luber Birgit; Seruca Raquel
E-cadherin mutations and cell motility: a genotype-phenotype correlation.
Experimental cell research 2009;315(8):1393-402.
2009: Oliveira Carla; Senz Janine; Kaurah Pardeep; Pinheiro Hugo; Sanges Remo; Haegert Anne; Corso Giovanni; Schouten Jan; Fitzgerald Rebecca; Vogelsang Holger; Keller Gisela; Dwerryhouse Sarah; Grimmer Donna; Chin Suet-Feung; Yang Han-Kwang; Jackson Charles E; Seruca Raquel; Roviello Franco; Stupka Elia; Caldas Carlos; Huntsman David
Germline CDH1 deletions in hereditary diffuse gastric cancer families.
Human molecular genetics 2009;18(9):1545-55.
2009: Seruca Raquel; Velho Sérgia; Oliveira Carla; Leite Marina; Matos Paulo; Jordan Peter
Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors.
Expert review of gastroenterology & hepatology 2009;3(1):5-9.
2009: Velho Sérgia; Oliveira Carla; Seruca Raquel
KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(1):158-9; author reply 159.
2009: Preto Ana; Gonçalves Joana; Rebocho Ana P; Figueiredo Joana; Meireles Ana M; Rocha Ana S; Vasconcelos Helena M; Seca Hugo; Seruca Raquel; Soares Paula; Sobrinho-Simões Manuel
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.
BMC cancer 2009;9():387.
2009: Pinto Carla; Veiga Isabel; Pinheiro Manuela; Peixoto Ana; Pinto Armando; Lopes José M; Reis Rui M; Oliveira Carla; Baptista Manuela; Roque Lúcia; Regateiro Fernando; Cirnes Luís; Hofstra Robert M W; Seruca Raquel; Castedo Sérgio; Teixeira Manuel R
TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset.
Familial cancer 2009;8(4):383-90.
2009: Oliveira Carla; Seruca Raquel; Carneiro Fátima
Hereditary gastric cancer.
Best practice & research. Clinical gastroenterology 2009;23(2):147-57.
2009: Pedrazzani Corrado; Corso Giovanni; Velho Sérgia; Leite Marina; Pascale Valeria; Bettarini Francesca; Marrelli Daniele; Seruca Raquel; Roviello Franco
Evidence of tumor microsatellite instability in gastric cancer with familial aggregation.
Familial cancer 2009;8(3):215-20.
2008: Carneiro Fátima; Oliveira Carla; Leite Marina; Seruca Raquel
Molecular targets and biological modifiers in gastric cancer.
Seminars in diagnostic pathology 2008;25(4):274-87.
2008: Simões-Correia Joana; Figueiredo Joana; Oliveira Carla; van Hengel Jolanda; Seruca Raquel; van Roy Frans; Suriano Gianpaolo
Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer.
Human molecular genetics 2008;17(22):3566-76.
2008: Canedo Paulo; Durães Cecília; Pereira Fábio; Regalo Gonçalo; Lunet Nuno; Barros Henrique; Carneiro Fátima; Seruca Raquel; Rocha Jorge; Machado José C
Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(9):2416-20.
2008: Matos Paulo; Oliveira Carla; Velho Sérgia; Gonçalves Vânia; da Costa Luís Teixiera; Moyer Mary Pat; Seruca Raquel; Jordan Peter
B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival.
Gastroenterology 2008;135(3):899-906.
2008: Karam R; Carvalho J; Bruno I; Graziadio C; Senz J; Huntsman D; Carneiro F; Seruca R; Wilkinson M F; Oliveira C
The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.
Oncogene 2008;27(30):4255-60.
2008: Preto A; Figueiredo J; Velho S; Ribeiro A S; Soares P; Oliveira C; Seruca R
BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.
The Journal of pathology 2008;214(3):320-7.
2008: Canedo Paulo; Castanheira-Vale Abel J; Lunet Nuno; Pereira Fábio; Figueiredo Céu; Gioia-Patricola Lydie; Canzian Federico; Moreira Herculano; Suriano Gianpaolo; Barros Henrique; Carneiro Fátima; Seruca Raquel; Machado José C
The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2008;17(1):28-32.
2008: Pinto Mafalda; Wu Ying; Mensink Rob G J; Cirnes Luís; Seruca Raquel; Hofstra Robert M W
Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype.
Cancer genetics and cytogenetics 2008;180(2):110-4.
2008: Carneiro F; Oliveira C; Suriano G; Seruca R
Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer.
Journal of clinical pathology 2008;61(1):25-30.
2008: Velho Sérgia; Moutinho Cátia; Cirnes Luís; Albuquerque Cristina; Hamelin Richard; Schmitt Fernando; Carneiro Fátima; Oliveira Carla; Seruca Raquel
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
BMC cancer 2008;8():255.
2008: Moutinho Cátia; Mateus Ana R; Milanezi Fernanda; Carneiro Fátima; Seruca Raquel; Suriano Gianpaolo
Epidermal growth factor receptor structural alterations in gastric cancer.
BMC cancer 2008;8():10.
2007: Svrcek Magali; El-Bchiri Jamila; Chalastanis Alexandra; Capel Emilie; Dumont Sylvie; Buhard Olivier; Oliveira Carla; Seruca Raquel; Bossard Céline; Mosnier Jean-François; Berger Françoise; Leteurtre Emmanuelle; Lavergne-Slove Anne; Chenard Marie-Pierre; Hamelin Richard; Cosnes Jacques; Beaugerie Laurent; Tiret Emmanuel; Duval Alex; Fléjou Jean-François
Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(27):4231-8.
2007: Suriano Gianpaolo; Azevedo Luisa; Novais Marta; Boscolo Barbara; Seruca Raquel; Amorim Antonio; Ghibaudi Elena Maria
In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model.
Human molecular genetics 2007;16(18):2209-14.
2007: Mateus Ana Rita; Seruca Raquel; Machado José Carlos; Keller Gisela; Oliveira Maria José; Suriano Gianpaolo; Luber Birgit
EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells.
Human molecular genetics 2007;16(13):1639-47.
2007: Preto Ana; Moutinho Cátia; Velho Sérgia; Oliveira Carla; Rebocho Ana Paula; Figueiredo Joana; Soares Paula; Lopes José Manuel; Seruca Raquel
A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation.
Virchows Archiv : an international journal of pathology 2007;450(6):619-26.
2007: Seixas Susana; Suriano Gianpaolo; Carvalho Filipa; Seruca Raquel; Rocha Jorge; Di Rienzo Anna
Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.
Molecular biology and evolution 2007;24(2):587-98.
2007: Oliveira C; Velho S; Moutinho C; Ferreira A; Preto A; Domingo E; Capelinha A F; Duval A; Hamelin R; Machado J C; Schwartz S; Carneiro F; Seruca R
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
Oncogene 2007;26(1):158-63.
2007: Alazzouzi Hafid; Suriano Gianpaolo; Guerra Angel; Plaja Alberto; Espín Eloi; Armengol Manel; Alhopuro Pia; Velho Sergia; Shinomura Yasuhisa; González-Aguilera Juan José; Yamamoto Hiroyuki; Aaltonen Lauri A; Moreno Víctor; Capellà Gabriel; Peinado Miguel Angel; Seruca Raquel; Arango Diego; Schwartz Simó
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.
Journal of medical genetics 2007;44(1):75-80.
2007: Davalos V; Dopeso H; Velho S; Ferreira A M; Cirnes L; Díaz-Chico N; Bilbao C; Ramírez R; Rodríguez G; Falcón O; León L; Niessen R C; Keller G; Dallenbach-Hellweg G; Espín E; Armengol M; Plaja A; Perucho M; Imai K; Yamamoto H; Gebert J F; Díaz-Chico J C; Hofstra R M; Woerner S M; Seruca R; Schwartz S; Arango D
High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.
Oncogene 2007;26(2):308-11.
2007: Roviello Franco; Corso Giovanni; Pedrazzani Corrado; Marrelli Daniele; De Falco Giulia; Suriano Gianpaolo; Vindigni Carla; Berardi Anna; Garosi Lorenzo; De Stefano Alfonso; Leoncini Lorenzo; Seruca Raquel; Pinto Enrico
High incidence of familial gastric cancer in Tuscany, a region in Italy.
Oncology 2007;72(3-4):243-7.
2006: Regalo G; Canedo P; Suriano G; Resende C; Campos M L; Oliveira M J; Figueiredo C; Rodrigues-Pereira P; Blin N; Seruca R; Carneiro F; Machado J C
C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression.
The Journal of pathology 2006;210(4):398-404.
2006: Suriano Gianpaolo; Seixas Susana; Rocha Jorge; Seruca Raquel
A model to infer the pathogenic significance of CDH1 germline missense variants.
Journal of molecular medicine (Berlin, Germany) 2006;84(12):1023-31.
2006: Oliveira Maria J; Costa Ana C; Costa Angela M; Henriques Lara; Suriano Gianpaolo; Atherton John C; Machado Jose C; Carneiro Fatima; Seruca Raquel; Mareel Marc; Leroy Ancy; Figueiredo Ceu
Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.
The Journal of biological chemistry 2006;281(46):34888-96.
2006: Castro P; Soares P; Gusmão L; Seruca R; Sobrinho-Simões M
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
Oncogene 2006;25(33):4620-7.
2006: Suriano Gianpaolo; Ferreira Paulo; Mateus Ana Rita; Correia Joana; Henriques Lara; Seruca Raquel
Genetics of hereditary diffuse gastric cancer: progress and future challenges.
Future oncology (London, England) 2006;2(3):363-70.
2006: Pereira Paulo S; Teixeira Alexandra; Pinho Sofia; Ferreira Paulo; Fernandes Joana; Oliveira Carla; Seruca Raquel; Suriano Gianpaolo; Casares Fernando
E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia.
Human molecular genetics 2006;15(10):1704-12.
2006: Frebourg T; Oliveira C; Hochain P; Karam R; Manouvrier S; Graziadio C; Vekemans M; Hartmann A; Baert-Desurmont S; Alexandre C; Lejeune Dumoulin S; Marroni C; Martin C; Castedo S; Lovett M; Winston J; Machado J C; Attié T; Jabs E W; Cai J; Pellerin Ph; Triboulet J P; Scotte M; Le Pessot F; Hedouin A; Carneiro F; Blayau M; Seruca R
Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer.
Journal of medical genetics 2006;43(2):138-42.
2006: Oliveira Carla; Seruca Raquel; Carneiro Fátima
Genetics, pathology, and clinics of familial gastric cancer.
International journal of surgical pathology 2006;14(1):21-33.
2005: Oliveira Carla; Velho Sérgia; Domingo Enric; Preto Ana; Hofstra Robert M W; Hamelin Richard; Yamamoto Hiroyuki; Seruca Raquel; Schwartz Simo
Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer.
Oncogene 2005;24(51):7630-4.
2005: Ferreira Paulo; Oliveira Maria José; Beraldi Eliana; Mateus Ana Rita; Nakajima Takashi; Gleave Martin; Yokota Jun; Carneiro Fátima; Huntsman David; Seruca Raquel; Suriano Gianpaolo
Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro.
Experimental cell research 2005;310(1):99-104.
2005: Velho Sérgia; Oliveira Carla; Ferreira Ana; Ferreira António Carlos; Suriano Gianpaolo; Schwartz Simó; Duval Alex; Carneiro Fátima; Machado José Carlos; Hamelin Richard; Seruca Raquel
The prevalence of PIK3CA mutations in gastric and colon cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(11):1649-54.
2005: Domingo Enric; Niessen Renée C; Oliveira Carla; Alhopuro Pia; Moutinho Catia; Espín Eloi; Armengol Manel; Sijmons Rolf H; Kleibeuker Jan H; Seruca Raquel; Aaltonen Lauri A; Imai Kohzoh; Yamamoto Hiroyuki; Schwartz Simó; Hofstra Robert M W
BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.
Oncogene 2005;24(24):3995-8.
2005: Ferreira António Carlos; Almeida Susana; Tavares Marta; Canedo Paulo; Pereira Fábio; Regalo Gonçalo; Figueiredo Céu; Trindade Eunice; Seruca Raquel; Carneiro Fátima; Amil Jorge; Machado José Carlos; Tavarela-Veloso Fernando
NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease.
Inflammatory bowel diseases 2005;11(4):331-9.
2005: Suriano Gianpaolo; Vrcelj Nikoleta; Senz Janine; Ferreira Paulo; Masoudi Hamid; Cox Kelley; Nabais Sergio; Lopes Carlos; Machado José Carlos; Seruca Raquel; Carneiro Fatima; Huntsman David G
beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer.
Genes, chromosomes & cancer 2005;42(3):238-46.
2005: Oliveira Carla; Moreira Herculano; Seruca Raquel; de Oliveira Manuel Cardoso; Carneiro Fátima
Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family.
Virchows Archiv : an international journal of pathology 2005;446(2):181-4.
2004: Oliveira Carla; Westra Jantine L; Arango Diego; Ollikainen Miina; Domingo Enric; Ferreira Ana; Velho Sérgia; Niessen Renee; Lagerstedt Kristina; Alhopuro Pia; Laiho Paivi; Veiga Isabel; Teixeira Manuel R; Ligtenberg Marjolijn; Kleibeuker Jan H; Sijmons Rolf H; Plukker John T; Imai Kohzoh; Lage Pedro; Hamelin Richard; Albuquerque Cristina; Schwartz Simo; Lindblom Annika; Peltomaki Päivi; Yamamoto Hiroyuki; Aaltonen Lauri A; Seruca Raquel; Hofstra Robert M W
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.
Human molecular genetics 2004;13(19):2303-11.
2004: Domingo E; Laiho P; Ollikainen M; Pinto M; Wang L; French A J; Westra J; Frebourg T; Espín E; Armengol M; Hamelin R; Yamamoto H; Hofstra R M W; Seruca R; Lindblom A; Peltomäki P; Thibodeau S N; Aaltonen L A; Schwartz S
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Journal of medical genetics 2004;41(9):664-8.
2004: Oliveira Carla; Ferreira Paulo; Nabais Sérgio; Campos Luisa; Ferreira Ana; Cirnes Luís; Alves Catarina Castro; Veiga Isabel; Fragoso Maria; Regateiro Fernando; Dias Luis Moreira; Moreira Herculano; Suriano Gianpaolo; Machado José Carlos; Lopes Carlos; Castedo Sérgio; Carneiro Fátima; Seruca Raquel
E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.
European journal of cancer (Oxford, England : 1990) 2004;40(12):1897-903.
2004: Keller G; Vogelsang H; Becker I; Plaschke S; Ott K; Suriano G; Mateus A R; Seruca R; Biedermann K; Huntsman D; Döring C; Holinski-Feder E; Neutzling A; Siewert J R; Höfler H
Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients.
Journal of medical genetics 2004;41(6):e89.
2004: Carneiro Fátima; Huntsman David G; Smyrk Thomas C; Owen David A; Seruca Raquel; Pharoah Paul; Caldas Carlos; Sobrinho-Simões Manuel
Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening.
The Journal of pathology 2004;203(2):681-7.
2004: Oliveira Carla; de Bruin Joyce; Nabais Sérgio; Ligtenberg Marjolijn; Moutinho Cátia; Nagengast Fokko M; Seruca Raquel; van Krieken Han; Carneiro Fátima
Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour.
Oncogene 2004;23(12):2236-40.
2004: Domingo Enric; Espín Eloi; Armengol Manel; Oliveira Carla; Pinto Mafalda; Duval Alex; Brennetot Caroline; Seruca Raquel; Hamelin Richard; Yamamoto Hiroyuki; Schwartz Simó
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.
Genes, chromosomes & cancer 2004;39(2):138-42.
2003: Oliveira Carla; Pinto Mafalda; Duval Alex; Brennetot Caroline; Domingo Enric; Espín Eloi; Armengol Manel; Yamamoto Hiroyuki; Hamelin Richard; Seruca Raquel; Schwartz Simó
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Oncogene 2003;22(57):9192-6.
2003: Suriano Gianpaolo; Oliveira Maria José; Huntsman David; Mateus Ana Rita; Ferreira Paulo; Casares Fernando; Oliveira Carla; Carneiro Fátima; Machado Josée Carlos; Mareel Marc; Seruca Raquel
E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells.
Human molecular genetics 2003;12(22):3007-16.
2003: Brennetot Caroline; Duval Alex; Hamelin Richard; Pinto Mafalda; Oliveira Carla; Seruca Raquel; Schwartz Simo
Frequent Ki-ras mutations in gastric tumors of the MSI phenotype.
Gastroenterology 2003;125(4):1282.
2003: Pinto Mafalda; Wu Ying; Suriano Gianpaolo; Mensink Rob G J; Duval Alex; Oliveira Carla; Carvalho Beatriz; Hamelin Richard; Seruca Raquel; Hofstra Robert M W
MBD4 mutations are rare in gastric carcinomas with microsatellite instability.
Cancer genetics and cytogenetics 2003;145(2):103-7.
2003: Suriano Gianpaolo; Mulholland David; de Wever Olivier; Ferreira Paulo; Mateus Ana Rita; Bruyneel Eric; Nelson Colleen C; Mareel Marc M; Yokota Jun; Huntsman David; Seruca Raquel
The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion.
Oncogene 2003;22(36):5716-9.
2003: Machado José Carlos; Figueiredo Céu; Canedo Paulo; Pharoah Paul; Carvalho Ralph; Nabais Sérgio; Castro Alves Catarina; Campos Maria Luisa; Van Doorn Leen-Jan; Caldas Carlos; Seruca Raquel; Carneiro Fátima; Sobrinho-Simões Manuel
A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma.
Gastroenterology 2003;125(2):364-71.
2003: Soares Paula; Trovisco Vítor; Rocha Ana Sofia; Lima Jorge; Castro Patrícia; Preto Ana; Máximo Valdemar; Botelho Tiago; Seruca Raquel; Sobrinho-Simões Manuel
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC.
Oncogene 2003;22(29):4578-80.
2003: Carvalho B; Pinto M; Cirnes L; Oliveira C; Machado J C; Suriano G; Hamelin R; Carneiro F; Seruca R
Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas.
European journal of cancer (Oxford, England : 1990) 2003;39(9):1222-7.
2003: Pinto Mafalda; Oliveira Carla; Cirnes Luis; Carlos Machado José; Ramires Maria; Nogueira Ana; Carneiro Fátima; Seruca Raquel
Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas.
The Journal of pathology 2003;200(1):32-8.
2003: Oliveira Carlo; Seruca Raquel; Caldas Carlos
Genetic screening for hereditary diffuse gastric cancer.
Expert review of molecular diagnostics 2003;3(2):201-15.
2003: Suriano Gianpaolo; Oliveira Carla; Ferreira Paulo; Machado José C; Bordin Maria C; De Wever Olivier; Bruyneel Erik A; Moguilevsky Nicole; Grehan Nicola; Porter Timothy R; Richards Frances M; Hruban Ralph H; Roviello Franco; Huntsman David; Mareel Marc; Carneiro Fátima; Caldas Carlos; Seruca Raquel
Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands.
Human molecular genetics 2003;12(5):575-82.
2003: Nabais Sérgio; Machado José Carlos; Lopes Carlos; Seruca Raquel; Carneiro Fátima; Sobrinho-Simões Manuel
Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis.
International journal of surgical pathology 2003;11(1):1-9.
2003: Thorstensen Lin; Holm Ruth; Lothe Ragnhild A; Tropé Claes; Carvalho Beatriz; Sobrinho-Simoes Manuel; Seruca Raquel
WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas.
Gastroenterology 2003;124(1):270-1.
2003: Mesquita Patrícia; Peixoto António J; Seruca Raquel; Hanski Christoph; Almeida Raquel; Silva Filipe; Reis Celso; David Leonor
Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas.
Cancer letters 2003;189(2):129-36.
2002: Suraweera Nirosha; Duval Alex; Reperant Maryline; Vaury Christelle; Furlan Daniela; Leroy Karen; Seruca Raquel; Iacopetta Barry; Hamelin Richard
Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.
Gastroenterology 2002;123(6):1804-11.
2002: Figueiredo Céu; Machado José Carlos; Pharoah Paul; Seruca Raquel; Sousa Sónia; Carvalho Ralph; Capelinha Ana Filipa; Quint Wim; Caldas Carlos; van Doorn Leen-Jan; Carneiro Fátima; Sobrinho-Simões Manuel
Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma.
Journal of the National Cancer Institute 2002;94(22):1680-7.
2002: Carvalho Ralph; Kayademir Tuncay; Soares Paula; Canedo Paulo; Sousa Sónia; Oliveira Carla; Leistenschneider Peter; Seruca Raquel; Gött Peter; Blin Nikolaus; Carneiro Fátima; Machado José Carlos
Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2002;82(10):1319-26.
2002: Carvalho B; Seruca R; Buys C H C M; Kok K
Novel expressed sequences obtained by means of a suppression subtractive hybridisation analysis from the 6q21 region that is frequently deleted in gastric cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(8):1126-32.
2002: Oliveira Carla; Bordin Maria Cristina; Grehan Nicola; Huntsman David; Suriano Gianpaolo; Machado José Carlos; Kiviluoto Tuula; Aaltonen Lauri; Jackson Charles E; Seruca Raquel; Caldas Carlos
Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.
Human mutation 2002;19(5):510-7.
2002: Duval Alex; Reperant Maryline; Compoint Aurore; Seruca Raquel; Ranzani Guglielmina N; Iacopetta Barry; Hamelin Richard
Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency.
Cancer research 2002;62(6):1609-12.
2001: Nabais S; Carneiro F; Nogueira A M; Machado J C; Seruca R; Sobrinho-Simões M
Re. 'Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways'.
The Journal of pathology 2001;195(5):636-7.
2001: Carvalho B; van der Veen A; Gärtner F; Carneiro F; Seruca R; Buys C H; Kok K
Allelic gains and losses in distinct regions of chromosome 6 in gastric carcinoma.
Cancer genetics and cytogenetics 2001;131(1):54-9.
2001: Huntsman D; Carneiro F; Lewis F; MacLeod P; Hayashi A; Monaghan K; Maung R; Seruca R; Jackson C; Caldas C
[Prophylactic gastrectomy in patients with deleterious E-cadherin gene mutation]
Gastroentérologie clinique et biologique 2001;25(10):931-2.
2001: Machado J C; Pharoah P; Sousa S; Carvalho R; Oliveira C; Figueiredo C; Amorim A; Seruca R; Caldas C; Carneiro F; Sobrinho-Simões M
Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma.
Gastroenterology 2001;121(4):823-9.
2001: Máximo V; Soares P; Seruca R; Rocha A S; Castro P; Sobrinho-Simões M
Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma.
Genes, chromosomes & cancer 2001;32(2):136-43.
2001: Rocha A S; Soares P; Seruca R; Máximo V; Matias-Guiu X; Cameselle-Teijeiro J; Sobrinho-Simões M
Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant.
The Journal of pathology 2001;194(3):358-66.
2001: Huntsman D G; Carneiro F; Lewis F R; MacLeod P M; Hayashi A; Monaghan K G; Maung R; Seruca R; Jackson C E; Caldas C
Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations.
The New England journal of medicine 2001;344(25):1904-9.
2001: Machado J C; Oliveira C; Carvalho R; Soares P; Berx G; Caldas C; Seruca R; Carneiro F; Sobrinho-Simöes M
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma.
Oncogene 2001;20(12):1525-8.
2001: Barroca H; Carvalho J L; da Costa M J; Cirnes L; Seruca R; Schmitt F C
Detection of N-myc amplification in neuroblastomas using Southern blotting on fine needle aspirates.
Acta cytologica 2001;45(2):169-72.
2000: Máximo V; Soares P; Machado J C; Seruca R; Sobrinho-Simões M
Mitochondrial DNA alteration in gastric cancer.
Gastroenterology 2000;119(6):1808-9.
2000: Pinto M; Oliveira C; Machado J C; Cirnes L; Tavares J; Carneiro F; Hamelin R; Hofstra R; Seruca R; Sobrinho-Simões M
MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile.
Laboratory investigation; a journal of technical methods and pathology 2000;80(12):1915-23.
2000: Alves C; Silva F; Gusmão L; Seruca R; Soares P; Reis R M; Amorim A
Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours.
European journal of human genetics : EJHG 2000;8(7):540-4.
1999: Caldas C; Carneiro F; Lynch H T; Yokota J; Wiesner G L; Powell S M; Lewis F R; Huntsman D G; Pharoah P D; Jankowski J A; MacLeod P; Vogelsang H; Keller G; Park K G; Richards F M; Maher E R; Gayther S A; Oliveira C; Grehan N; Wight D; Seruca R; Roviello F; Ponder B A; Jackson C E
Familial gastric cancer: overview and guidelines for management.
Journal of medical genetics 1999;36(12):873-80.
1999: Carneiro F; Machado J C; Seruca R; Sobrinho-Simões M
E-cadherin changes in gastric carcimona.
Histopathology 1999;35(5):477-8.
1999: Nogueira A M; Carneiro F; Seruca R; Cirnes L; Veiga I; Machado J C; Sobrinho-Simões M
Microsatellite instability in hyperplastic and adenomatous polyps of the stomach.
Cancer 1999;86(9):1649-56.
1999: Máximo V; Soares P; Seruca R; Sobrinho-Simões M
Comments on: mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319.
European journal of cancer (Oxford, England : 1990) 1999;35(9):1407-8.
1999: Carvalho B; Seruca R; Carneiro F; Buys C H; Kok K
Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1.
Genes, chromosomes & cancer 1999;26(1):29-34.
1999: Schmitt F C; Soares R; Gobbi H; Milanezzi F; Santos-Silva F; Cirnes L; Costa C; Seruca R
Microsatellite instability in medullary breast carcinomas.
International journal of cancer. Journal international du cancer 1999;82(5):644-7.
1998: Schmitt F C; Soares R; Seruca R
Bilateral apocrine carcinoma of the breast. Molecular and immunocytochemical evidence for two independent primary tumours.
Virchows Archiv : an international journal of pathology 1998;433(6):505-9.
1998: Schmitt F C; Soares R; Cirnes L; Seruca R
PCR amplification of DNA obtained from archived hematoxylin-eosin--and giemsa-stained breast cancer aspirates.
Diagnostic cytopathology 1998;19(5):395-7.
1998: Oliveira C; Seruca R; Seixas M; Sobrinho-Simões M
The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes.
The American journal of pathology 1998;153(4):1211-9.
1998: Peixoto A; dos Santos M R; Seruca R; Amorim A; Castedo S
Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: evidence for a "protector" haplotype.
European journal of human genetics : EJHG 1998;6(5):518-22.
1998: Gayther S A; Gorringe K L; Ramus S J; Huntsman D; Roviello F; Grehan N; Machado J C; Pinto E; Seruca R; Halling K; MacLeod P; Powell S M; Jackson C E; Ponder B A; Caldas C
Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.
Cancer research 1998;58(18):4086-9.
1998: Zhou X P; Hoang J M; Li Y J; Seruca R; Carneiro F; Sobrinho-Simoes M; Lothe R A; Gleeson C M; Russell S E; Muzeau F; Fléjou J F; Hoang-Xuan K; Lidereau R; Thomas G; Hamelin R
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites.
Genes, chromosomes & cancer 1998;21(2):101-7.
1998: Schmitt F C; Soares R; Cirnes L; Seruca R
P53 in breast carcinomas: association between presence of mutation and immunohistochemical expression using a semiquantitative approach.
Pathology, research and practice 1998;194(12):815-9.
1997: Silva F; Gusmão L; Alves C; Seruca R; David L; Amorim A
Tetra- and pentanucleotide short tandem repeat instability in gastric cancer.
Electrophoresis 1997;18(9):1633-6.
1997: Carvalho F; Seruca R; David L; Amorim A; Seixas M; Bennett E; Clausen H; Sobrinho-Simões M
MUC1 gene polymorphism and gastric cancer--an epidemiological study.
Glycoconjugate journal 1997;14(1):107-11.
1996: Gärtner F; David L; Seruca R; Machado J C; Sobrinho-Simões M
Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice.
Virchows Archiv : an international journal of pathology 1996;428(2):91-8.
1996: dos Santos N R; Seruca R; Constância M; Seixas M; Sobrinho-Simões M
Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis.
Gastroenterology 1996;110(1):38-44.
1995: Queimado L; Seruca R; Costa-Pereira A; Castedo S
Identification of two distinct regions of deletion at 6q in gastric carcinoma.
Genes, chromosomes & cancer 1995;14(1):28-34.
1995: Seruca R; Suijkerbuijk R F; Gärtner F; Criado B; Veiga I; Olde-Weghuis D; David L; Castedo S; Sobrinho-Simões M
Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer.
Cancer genetics and cytogenetics 1995;82(2):140-5.
1995: Criado B; Barros A; Suijkerbuijk R F; Weghuis D O; Seruca R; Fonseca E; Castedo S
Detection of numerical alterations for chromosomes 7 and 12 in benign thyroid lesions by in situ hybridization. Histological implications.
The American journal of pathology 1995;147(1):136-44.
1995: Seruca R; Santos N R; David L; Constância M; Barroca H; Carneiro F; Seixas M; Peltomäki P; Lothe R; Sobrinho-Simões M
Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile.
International journal of cancer. Journal international du cancer 1995;64(1):32-6.
1994: Constância M; Seruca R; Carneiro F; Silva F; Castedo S
Retinoblastoma gene structure and product expression in human gastric carcinomas.
British journal of cancer 1994;70(5):1018-24.
1994: Seruca R; David L; Castedo S; Veiga I; Børresen A L; Sobrinho-Simões M
p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases.
Cancer genetics and cytogenetics 1994;75(1):45-50.
1994: de Leeuw B; Balemans M; Weghuis D O; Seruca R; Janz M; Geraghty M T; Gilgenkrantz S; Ropers H H; Geurts van Kessel A
Molecular cloning of the synovial sarcoma-specific translocation (X;18)(p11.2;q11.2) breakpoint.
Human molecular genetics 1994;3(5):745-9.
1994: Carneiro F; Seruca R; Ribeiro A C; Sobrinho-Simões M
An immunohistochemical study of ras oncoprotein expression in gastric carcinoma.
Cancer 1994;73(7):2010-2.
1993: Peltomäki P; Lothe R A; Aaltonen L A; Pylkkänen L; Nyström-Lahti M; Seruca R; David L; Holm R; Ryberg D; Haugen A
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.
Cancer research 1993;53(24):5853-5.
1993: Seruca R; Castedo S; Correia C; Gomes P; Carneiro F; Soares P; de Jong B; Sobrinho-Simões M
Cytogenetic findings in eleven gastric carcinomas.
Cancer genetics and cytogenetics 1993;68(1):42-8.
1993: Carneiro F; David L; Seruca R; Castedo S; Nesland J M; Sobrinho-Simões M
Hyperplastic polyposis and diffuse carcinoma of the stomach. A study of a family.
Cancer 1993;72(2):323-9.
1992: Seruca R; Carneiro F; Soares P; Fonseca E; Castedo S
Clonal cytogenetic abnormalities and telomeric associations in a fibroxanthoma of the stomach.
Genes, chromosomes & cancer 1992;5(4):407-9.
1992: Castedo S; Correia C; Gomes P; Seruca R; Soares P; Carneiro F; Sobrinho-Simões M
Loss of Y chromosome in gastric carcinoma. Fact or artifact?
Cancer genetics and cytogenetics 1992;61(1):39-41.
1992: David L; Seruca R; Nesland J M; Soares P; Sansonetty F; Holm R; Børresen A L; Sobrinho-Simões M
c-erbB-2 expression in primary gastric carcinomas and their metastases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1992;5(4):384-90.
1992: Seruca R; David L; Holm R; Nesland J M; Fangan B M; Castedo S; Sobrinho-Simões M; Børresen A L
P53 mutations in gastric carcinomas.
British journal of cancer 1992;65(5):708-10.
1991: Seruca R; Carneiro F; Castedo S; David L; Lopes C; Sobrinho-Simões M
Familial gastric polyposis revisited. Autosomal dominant inheritance confirmed.
Cancer genetics and cytogenetics 1991;53(1):97-100.
1990: Lopes J M; Seruca R; Hall A P; Branco P; Castedo S M
Cytogenetic study of a sclerosing stromal tumor of the ovary.
Cancer genetics and cytogenetics 1990;49(1):103-6.
1989: Castedo S M; de Jong B; Oosterhuis J W; Seruca R; Idenburg V J; Dam A; te Meerman G; Koops H S; Sleijfer D T
Chromosomal changes in human primary testicular nonseminomatous germ cell tumors.
Cancer research 1989;49(20):5696-701.
1989: Oosterhuis J W; Castedo S M; de Jong B; Seruca R; Dam A; Vos A; de Koning J; Schraffordt Koops H; Sleijfer D T
A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases.
Cancer genetics and cytogenetics 1989;41(1):105-14.
1989: Castedo S M; de Jong B; Oosterhuis J W; Idenburg V J; Seruca R; Buist J; te Meerman G J; Schraffordt Koops H; Sleijfer D T
Chromosomal changes in mature residual teratomas following polychemotherapy.
Cancer research 1989;49(3):672-6.
1989: Molenaar W M; DeJong B; Buist J; Idenburg V J; Seruca R; Vos A M; Hoekstra H J
Chromosomal analysis and the classification of soft tissue sarcomas.
Laboratory investigation; a journal of technical methods and pathology 1989;60(2):266-74.
1989: Castedo S M; de Jong B; Oosterhuis J W; Seruca R; te Meerman G J; Dam A; Schraffordt Koops H
Cytogenetic analysis of ten human seminomas.
Cancer research 1989;49(2):439-43.
1988: Oosterhuis J W; Castedo S M; de Jong B; Seruca R; Buist J; Schraffordt Koops H; Leeuw J B
Karyotyping and DNA flow cytometry of an orchidoblastoma.
Cancer genetics and cytogenetics 1988;36(1):7-11.
1988: Castedo S M; de Jong B; Oosterhuis J W; Seruca R; Idenburg V J; Buist J; Sleijfer D T
i(12p)-negative testicular germ cell tumors. A different group?
Cancer genetics and cytogenetics 1988;35(2):171-8.
1988: Castedo S M; de Jong B; Oosterhuis J W; Seruca R; Buist J; Koops H S
Cytogenetic study of a combined germ cell tumor of the testis.
Cancer genetics and cytogenetics 1988;35(2):159-65.
1988: Castedo S M; Seruca R; Oosterhuis J W; de Jong B; Schraffordt Koops H; Leeuw J A
Cytogenetics of a case of osteosarcoma.
Cancer genetics and cytogenetics 1988;32(1):149-51.
1988: Castedo S M; Oosterhuis J W; de Jong B; Seruca R; Dam A; Buist J; Schraffordt Koops H; Sleijfer D T
A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma?
Cancer genetics and cytogenetics 1988;32(1):51-7.

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