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Kenneth Setchell

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Ying Sun; Charles V Vorhees; Michael T Williams; David P Witte; Matt Zamzow; Wujuan Zhang; Sonya Barnes; Brian Quinn; Huimin Ran; Kenneth D R Setchell; Gregory A Grabowski
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.
Kenneth D R Setchell; Sohela Shah; David Suskind; Brian Wolfe; Wujuan Zhang; Mohammed Al-Edreesi; Kevin E Bove; James Heubi; Alan F Hofmann; Pinky Jha; Alex S Knisely; Joel E Lavine; Nancy C O'Connell; Carol Potter; Philip Rosenthal; David W Russell; Laura N Bull
Genetic defects in bile Acid conjugation cause fat-soluble vitamin deficiency.
Ying Sun; You-Hai Xu; Wujuan Zhang; Nupur Dasgupta; Benjamin Liou; Brian Quinn; Kenneth D R Setchell; Gregory A Grabowski
Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease.

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2013: Ying Sun; Charles V Vorhees; Michael T Williams; David P Witte; Matt Zamzow; Wujuan Zhang; Sonya Barnes; Brian Quinn; Huimin Ran; Kenneth D R Setchell; Gregory A Grabowski
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.
Human molecular genetics 2013;22(12):2435-50.
2013: Kenneth D R Setchell; Sohela Shah; David Suskind; Brian Wolfe; Wujuan Zhang; Mohammed Al-Edreesi; Kevin E Bove; James Heubi; Alan F Hofmann; Pinky Jha; Alex S Knisely; Joel E Lavine; Nancy C O'Connell; Carol Potter; Philip Rosenthal; David W Russell; Laura N Bull
Genetic defects in bile Acid conjugation cause fat-soluble vitamin deficiency.
Gastroenterology 2013;144(5):945-955.e6.
2013: Ying Sun; You-Hai Xu; Wujuan Zhang; Nupur Dasgupta; Benjamin Liou; Brian Quinn; Kenneth D R Setchell; Gregory A Grabowski
Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease.
PloS one 2013;8(3):e57560.
2013: Robert M Littleton; Sandra Nelson; Kenneth D R Setchell; Hong Tang; Kevin Haworth; Jay R Hove
Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia.
PloS one 2013;8(1):e52409.
2012: Rama Pai; Emile Plise; Laurent Salphati; Leah Schutt; Kenneth D R Setchell; Joseph Ware; Dorothy French; Dylan Hartley; Kathy Hotzel; Veronique Lauriault; Ning Ma; Donna Dambach
Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):446-56.
2012: Vered Molho-Pessach; Jonathan J Rios; Kenneth D R Setchell; Chao Xing; Jonathan C Cohen; Helen H Hobbs
Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology.
Hepatology (Baltimore, Md.) 2012;55(4):1139-45.
2012: Ying Sun; You-Hai Xu; Wujuan Zhang; Rick Hamler; Benjamin Liou; Brian Quinn; Kenneth D R Setchell; Gregory A Grabowski
Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease.
The Journal of biological chemistry 2012;287(6):4275-87.
2011: Carlo Clerici; Nadia Corazzi; Giorgio Di Matteo; Francesco Galli; Vittorio Giuliano; Stefania Gizzi; Elisabetta Nardi; Gabriele Perriello; Stefania Asciutti; Pier Maria Battezzati; Danilo Castellani; Kenneth D R Setchell
Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetes.
Diabetes care 2011;34(9):1946-8.
2011: Nadine M Brown; Stephanie L Lindley; David P Witte; Kenneth D R Setchell
Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.
Reproductive toxicology (Elmsford, N.Y.) 2011;32(1):33-42.
2011: Stephenson W Nkinin; Kenneth D R Setchell; James R Stringer; José-Luis Giner; Scott Keely; Edna S Kaneshiro
Pneumocystis carinii sterol 14α-demethylase activity in Saccharomyces cerevisiae erg11 knockout mutant: sterol biochemistry.
The Journal of eukaryotic microbiology 2011;58(4):383-92.
2011: Ying Sun; Huimin Ran; Benjamin Liou; Brian Quinn; Matt Zamzow; Wujuan Zhang; Jacek Bielawski; Kazuyuki Kitatani; Kenneth D R Setchell; Yusuf A Hannun; Gregory A Grabowski
Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
PloS one 2011;6(4):e19037.
2010: Carol J Fabian; Bruce F Kimler; Carola M Zalles; Jennifer R Klemp; Brian K Petroff; Qamar J Khan; Priyanka Sharma; Kenneth D R Setchell; Xueheng Zhao; Teresa A Phillips; Trina Metheny; Jennifer R Hughes; Hung-Wen Yeh; Karen A Johnson
Reduction in Ki-67 in benign breast tissue of high-risk women with the lignan secoisolariciresinol diglycoside.
Cancer prevention research (Philadelphia, Pa.) 2010;3(10):1342-50.
2010: Rohit Kohli; Michelle Kirby; Kenneth D R Setchell; Pinky Jha; Kori Klustaitis; Laura A Woollett; Paul Pfluger; William F Balistreri; Patrick Tso; Ronald J Jandacek; Stephen C Woods; James Heubi; Matthias H Tschoep; David A D'Alessio; Noah F Shroyer; Randy J Seeley
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(3):G652-60.
2010: Kenneth D R Setchell; Carlo Clerici
Equol: history, chemistry, and formation.
The Journal of nutrition 2010;140(7):1355S-62S.
2010: Kenneth D R Setchell; Carlo Clerici
Equol: pharmacokinetics and biological actions.
The Journal of nutrition 2010;140(7):1363S-8S.
2010: Nadine M Brown; Carrie A Belles; Stephanie L Lindley; Linda D Zimmer-Nechemias; Xueheng Zhao; David P Witte; Mi-Ok Kim; Kenneth D R Setchell
The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.
Carcinogenesis 2010;31(5):886-93.
2009: Stefania Asciutti; Danilo Castellani; Elisabetta Nardi; Olivia Morelli; Mattia Clementi; Fabio Chistolini; Giorgio Gentili; Kenneth D R Setchell; Nancy O'Connell; Roberto Pellicciari; Carlo Clerici
A new amino acid derivative of ursodeoxycholate, (N-L-Glutamyl)-UDCA (UDCA-Glu), to selectively release UDCA in the colon.
Anticancer research 2009;29(12):4971-9.
2009: Kenneth D R Setchell; Xueheng Zhao; Susan E Shoaf; Karen Ragland
The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.
The Journal of nutrition 2009;139(11):2037-43.
2009: Emmanuel Gonzales; Marie F Gerhardt; Monique Fabre; Kenneth D R Setchell; Anne Davit-Spraul; Isabelle Vincent; James Heubi; Olivier Bernard; Emmanuel Jacquemin
Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy.
Gastroenterology 2009;137(4):1310-1320.e1-3.
2009: Mark Messina; Shaw Watanabe; Kenneth D R Setchell
Report on the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment.
The Journal of nutrition 2009;139(4):796S-802S.
2009: Carey E Gleason; Cynthia M Carlsson; Jodi H Barnet; Sarah A Meade; Kenneth D R Setchell; Craig S Atwood; Sterling C Johnson; Michele L Ries; Sanjay Asthana
A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
Age and ageing 2009;38(1):86-93.
2008: Tamara Frankenberg; Tamir Miloh; Frank Y Chen; Meenakshisundaram Ananthanarayanan; An-Qiang Sun; Natarajan Balasubramaniyan; Irwin Arias; Kenneth D R Setchell; Frederick J Suchy; Benjamin L Shneider
The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.
Hepatology (Baltimore, Md.) 2008;48(6):1896-905.
2008: Russell L Legg; Jessica R Tolman; Cameron T Lovinger; Edwin D Lephart; Kenneth D R Setchell; Merrill J Christensen
Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate.
Reproductive biology and endocrinology : RB&E 2008;6():57.
2007: Julius E Thigpen; Kenneth D R Setchell; Elizabeth Padilla-Banks; Joseph K Haseman; Hannah E Saunders; Gordon F Caviness; Grace E Kissling; Mary G Grant; Diane B Forsythe
Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats.
Environmental health perspectives 2007;115(12):1717-26.
2007: Emily K Thomas; Jose A Cancelas; Hee-Don Chae; Adrienne D Cox; Patricia J. Keller; Danilo Perrotti; Paolo Neviani; Brian J Druker; Kenneth D R Setchell; Yi Zheng; Chad E Harris; David A Williams
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.
Cancer cell 2007;12(5):467-78.
2007: Carlo Clerici; Kenneth D R Setchell; Pier Maria Battezzati; Matteo Pirro; Vittorio Giuliano; Stefania Asciutti; Danilo Castellani; Elisabetta Nardi; Giuseppe Sabatino; Stefano Orlandi; Monia Baldoni; Olivia Morelli; Elmo Mannarino; Antonio Morelli
Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk.
The Journal of nutrition 2007;137(10):2270-8.
2007: James Heubi; Kenneth D R Setchell; Kevin E Bove
Inborn errors of bile acid metabolism.
Seminars in liver disease 2007;27(3):282-94.
2007: Heidi C Shea; Daphne D Head; Kenneth D R Setchell; David W Russell
Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11526-33.
2006: Kenneth D R Setchell; Sidney J Cole
Method of defining equol-producer status and its frequency among vegetarians.
The Journal of nutrition 2006;136(8):2188-93.
2006: Carlo Clerici; Danilo Castellani; Stefania Asciutti; Roberto Pellicciari; Kenneth D R Setchell; Nancy C O'Connell; Bahman M Sadeghpour; Emidio Camaioni; Stefano Fiorucci; Barbara Renga; Elisabetta Nardi; Giuseppe Sabatino; Mattia Clementi; Vittorio Giuliano; Monia Baldoni; Stefano Orlandi; Alessandro Mazzocchi; Antonio Morelli; Olivia Morelli
3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats.
Toxicology and applied pharmacology 2006;214(2):199-208.
2006: Kenneth D R Setchell; James Heubi
Defects in bile acid biosynthesis--diagnosis and treatment.
Journal of pediatric gastroenterology and nutrition 2006;43 Suppl 1():S17-22.
2006: Kenneth D R Setchell
Assessing risks and benefits of genistein and soy.
Environmental health perspectives 2006;114(6):A332-3.
2006: Paul R Gardner; Anne M Gardner; Wayne T Brashear; Tomohiko Suzuki; Angela N Hvitved; Kenneth D R Setchell; John S Olson
Hemoglobins dioxygenate nitric oxide with high fidelity.
Journal of inorganic biochemistry 2006;100(4):542-50.
2006: Laura A Woollett; Y Wang; Donna D Buckley; Lihang Yao; S Chin; Norman A Granholm; Peter J H Jones; Kenneth D R Setchell; Patrick Tso; James Heubi
Micellar solubilisation of cholesterol is essential for absorption in humans.
Gut 2006;55(2):197-204.
2006: Aedin Cassidy; Jonathan E Brown; Anne Hawdon; Marian S Faughnan; Laurence J King; Joe Millward; Linda Zimmer-Nechemias; Brian Wolfe; Kenneth D R Setchell
Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods.
The Journal of nutrition 2006;136(1):45-51.
2005: Paula J Waters; Minesh Khashu; Yolanda Lillquist; Christof Senger; Andre Mattman; Michelle Demos; Kenneth D R Setchell; Anthony Rupar; patrick scott; Nenad Blau; Hilary D Vallance
Neonatal hyperphenylalaninemia, perinatal hemochromatosis, and renal tubulopathy: a unique patient or a novel metabolic disorder?
Molecular genetics and metabolism 2005;86 Suppl 1():S148-52.
2005: Luigi Puglielli; Avi Friedlich; Kenneth D R Setchell; Seiichi Nagano; Carlos Opazo; Robert A Cherny; Kevin J Barnham; John D Wade; Simon Melov; Dora M. Kovacs; Ashley I Bush
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
The Journal of clinical investigation 2005;115(9):2556-63.
2005: Tammy J Stephenson; Kenneth D R Setchell; Cyril W C Kendall; D J A Jenkins; James W Anderson; Paolo Fanti
Effect of soy protein-rich diet on renal function in young adults with insulin-dependent diabetes mellitus.
Clinical nephrology 2005;64(1):1-11.
2005: Joanne M Donovan; K Von Bergmann; Kenneth D R Setchell; Jonathan L Isaacsohn; Anuradha S Pappu; D Roger Illingworth; T Olson; Steven K Burke
Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia.
Digestive diseases and sciences 2005;50(7):1232-8.
2005: Kenneth D R Setchell; Carlo Clerici; Edwin D Lephart; Sidney J Cole; Claire Heenan; Danilo Castellani; Brian E Wolfe; Linda Nechemias-Zimmer; Nadine M Brown; Trent D Lund; Robert J Handa; James Heubi
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.
The American journal of clinical nutrition 2005;81(5):1072-9.
2005: Edwin D Lephart; Kenneth D R Setchell; Trent D Lund
Phytoestrogens: hormonal action and brain plasticity.
Brain research bulletin 2005;65(3):193-8.
2005: Kenneth D R Setchell; Amnon Brzezinski; Nadine M Brown; Pankaj B Desai; Murad Melhem; Trevor Meredith; Linda Zimmer-Nechimias; Brian Wolfe; Yoram Cohen; Yoav Blatt
Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.
Journal of agricultural and food chemistry 2005;53(6):1938-44.
2005: Kenneth D R Setchell; L Galzigna; N O'Connell; Gabriele Brunetti; Horst-Dietmar Tauschel
Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichment.
Alimentary pharmacology & therapeutics 2005;21(6):709-21.
2005: Lihong Bu; Kenneth D R Setchell; Edwin D Lephart
Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats.
Reproductive biology and endocrinology : RB&E 2005;3():58.
2004: Edwin D Lephart; James P Porter; Dawson W Hedges; Trent D Lund; Kenneth D R Setchell
Phytoestrogens: implications in neurovascular research.
Current neurovascular research 2004;1(5):455-64.
2004: Eva Lydeking-Olsen; Jens-Erik Beck-Jensen; Kenneth D R Setchell; Trine Holm-Jensen
Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial.
European journal of nutrition 2004;43(4):246-57.
2004: Kevin E Bove; James Heubi; William F Balistreri; Kenneth D R Setchell
Bile acid synthetic defects and liver disease: a comprehensive review.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2004;7(4):315-34.
2004: Hector Vilca-Melendez; Mohamed Rela; Kenneth D R Setchell; Gerard M Murphy; Nigel D Heaton
Bile acids analysis: a tool to assess graft function in human liver transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(6):286-92.
2004: Jeffery L Smith; Peter J Lewindon; Anita C Hoskins; Tamara N Pereira; Kenneth D R Setchell; Nancy C O'Connell; Ross W Shepherd; Grant A Ramm
Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis.
Hepatology (Baltimore, Md.) 2004;39(6):1673-82.
2004: Jr. John W. Erdman; Thomas M Badger; Johanna W Lampe; Kenneth D R Setchell; Mark Messina
Not all soy products are created equal: caution needed in interpretation of research results.
The Journal of nutrition 2004;134(5):1229S-1233S.
2004: Mark Messina; Jr. John W. Erdman; Kenneth D R Setchell
Introduction to and perspectives from the Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease.
The Journal of nutrition 2004;134(5):1205S-1206S.
2004: Trent D Lund; Daniel J Munson; Megan E Haldy; Kenneth D R Setchell; Edwin D Lephart; Robert J Handa
Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback.
Biology of reproduction 2004;70(4):1188-95.
2004: Edwin D Lephart; Kenneth D R Setchell; Robert J Handa; Trent D Lund
Behavioral effects of endocrine-disrupting substances: phytoestrogens.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(4):443-54.
2004: Julius E Thigpen; Kenneth D R Setchell; Hannah E Saunders; Joseph K Haseman; Mary G Grant; Diane B Forsythe
Selecting the appropriate rodent diet for endocrine disruptor research and testing studies.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(4):401-16.
2003: Julius E Thigpen; Joseph K Haseman; Hannah E Saunders; Kenneth D R Setchell; Mary G Grant; Diane B Forsythe
Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 mice.
Comparative medicine 2003;53(6):607-15.
2003: Srikanth C Nallani; Tracy A Glauser; Niresh Hariparsad; Kenneth D R Setchell; Donna J Buckley; Arthur R Buckley; Pankaj B Desai
Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.
Epilepsia 2003;44(12):1521-8.
2003: David Kritchevsky; Shirley A Tepper; Susanne K Czarnecki; Brian Wolfe; Kenneth D R Setchell
Serum and aortic levels of phytosterols in rabbits fed sitosterol or sitostanol ester preparations.
Lipids 2003;38(11):1115-8.
2003: Amethyst C Kurbegov; Kenneth D R Setchell; Joel E Haas; Gary W Mierau; Michael R Narkewicz; John D Bancroft; Frederick M Karrer; Ronald Sokol
Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile.
Gastroenterology 2003;125(4):1227-34.
2003: Kenneth D R Setchell; Eva Lydeking-Olsen
Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies.
The American journal of clinical nutrition 2003;78(3 Suppl):593S-609S.
2003: Kenneth D R Setchell; Sidney J Cole
Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling.
Journal of agricultural and food chemistry 2003;51(14):4146-55.
2003: Edwin D Lephart; Reuben W Rhees; Kenneth D R Setchell; Lihong Bu; Trent D Lund
Estrogens and phytoestrogens: brain plasticity of sexually dimorphic brain volumes.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):299-309.
2003: Jeffrey B Cheng; Emmanuel Jacquemin; Marie Gerhardt; Hisham Nazer; Danièle Cresteil; James Heubi; Kenneth D R Setchell; David W Russell
Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.
The Journal of clinical endocrinology and metabolism 2003;88(4):1833-41.
2003: Kenneth D R Setchell; Nadine M Brown; Pankaj B Desai; Linda Zimmer-Nechimias; Brian Wolfe; Abhijeet S Jakate; Vivian Creutzinger; James Heubi
Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes.
The Journal of nutrition 2003;133(4):1027-35.
2003: Kenneth D R Setchell; Marian S Faughnan; Tony Avades; Linda Zimmer-Nechemias; Nadine M Brown; Brian E Wolfe; Wayne T Brashear; Panjak Desai; Mark F Oldfield; Nigel P Botting; Aedin Cassidy
Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women.
The American journal of clinical nutrition 2003;77(2):411-9.
2003: Carla Colombo; Kenneth D R Setchell; Andrea Crosignani; Arianna Biffi; Nancy O'Connell; Massimo Agosti; Antonio Marini
Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigs.
Biology of the neonate 2003;83(1):36-41.
2003: Kenneth D R Setchell; James Heubi; Kevin E Bove; Nancy C O'Connell; Tracy Brewsaugh; Steven J Steinberg; Ann B Moser; Robert H Squires
Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy.
Gastroenterology 2003;124(1):217-32.
2002: Kenneth D R Setchell; Nadine M Brown; Eva Lydeking-Olsen
The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones.
The Journal of nutrition 2002;132(12):3577-84.
2002: James Heubi; David A Wiechmann; Vivian Creutzinger; Kenneth D R Setchell; Robert H Squires; Robert Couser; Philip Rhodes
Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease.
The Journal of pediatrics 2002;141(2):237-42.
2002: Kenneth D R Setchell; Nadine M Brown; Linda Zimmer-Nechemias; Wayne T Brashear; Brian E Wolfe; Abby S Kirschner; James Heubi
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.
The American journal of clinical nutrition 2002;76(2):447-53.
2002: Jill Nicholls; Bill L Lasley; Steven T Nakajima; Kenneth D R Setchell; Barbara O Schneeman
Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women.
The Journal of nutrition 2002;132(4):708-14.
2002: Lihang Yao; James Heubi; Donna D Buckley; Humberto Fierra; Kenneth D R Setchell; Norman A Granholm; Patrick Tso; David Y Hui; Laura A Woollett
Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal.
Journal of lipid research 2002;43(4):654-60.
2002: Edwin D Lephart; Timothy W West; K Scott Weber; Reuben W Rhees; Kenneth D R Setchell; Herman Adlercreutz; Trent D Lund
Neurobehavioral effects of dietary soy phytoestrogens.
Neurotoxicology and teratology 2002;24(1):5-16.
2001: Kenneth D R Setchell
Soy isoflavones--benefits and risks from nature's selective estrogen receptor modulators (SERMs).
Journal of the American College of Nutrition 2001;20(5 Suppl):354S-362S; discussion 381S-383S.
2001: Trent D Lund; Reuben W Rhees; Kenneth D R Setchell; Edwin D Lephart
Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens.
Brain research 2001;914(1-2):92-9.
2001: Michael D Scheiber; James Liu; M T Ravi Subbiah; Robert W Rebar; Kenneth D R Setchell
Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women.
Menopause (New York, N.Y.) 2001;8(5):384-92.
2001: K Scott Weber; Kenneth D R Setchell; D M Stocco; Edwin D Lephart
Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats.
The Journal of endocrinology 2001;170(3):591-9.
2001: Nadine M Brown; Kenneth D R Setchell
Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones.
Laboratory investigation; a journal of technical methods and pathology 2001;81(5):735-47.
2001: Kenneth D R Setchell; Nadine M Brown; P Desai; Linda Zimmer-Nechemias; Brian E Wolfe; Wayne T Brashear; A S Kirschner; Aedin Cassidy; James Heubi
Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.
The Journal of nutrition 2001;131(4 Suppl):1362S-75S.
2001: K Scott Weber; Kenneth D R Setchell; Edwin D Lephart
Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens.
Brain research. Developmental brain research 2001;126(2):217-21.
2001: Trent D Lund; T W West; L Y Tian; Lihong Bu; D L Simmons; Kenneth D R Setchell; Herman Adlercreutz; Edwin D Lephart
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens.
BMC neuroscience 2001;2():20.
2000: Edwin D Lephart; J M Thompson; Kenneth D R Setchell; Herman Adlercreutz; K Scott Weber
Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats.
Brain research 2000;859(1):123-31.
2000: Kenneth D R Setchell
Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants.
The Journal of nutrition 2000;130(3):654S-5S.
2000: Kevin E Bove; C C Daugherty; W Tyson; Gary W Mierau; James Heubi; William F Balistreri; Kenneth D R Setchell
Bile acid synthetic defects and liver disease.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2000;3(1):1-16.
1999: Howard G Shertzer; Alvaro Puga; C y Chang; P Smith; Daniel W Nebert; Kenneth D R Setchell; Timothy P Dalton
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Chemico-biological interactions 1999;123(1):31-49.
1999: Julius E Thigpen; Kenneth D R Setchell; K B Ahlmark; Jacqueline Locklear; T Spahr; Gordon F Caviness; MF Goelz; Joseph K Haseman; Retha R Newbold; Diane B Forsythe
Phytoestrogen content of purified, open- and closed-formula laboratory animal diets.
Laboratory animal science 1999;49(5):530-6.
1999: K Scott Weber; NA Jacobson; Kenneth D R Setchell; Edwin D Lephart
Brain aromatase and 5alpha-reductase, regulatory behaviors and testosterone levels in adult rats on phytoestrogen diets.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;221(2):131-5.
1999: Julius E Thigpen; Kenneth D R Setchell; MF Goelz; Diane B Forsythe
The phytoestrogen content of rodent diets.
Environmental health perspectives 1999;107(4):A182-3.
1999: Kenneth D R Setchell; Aedin Cassidy
Dietary isoflavones: biological effects and relevance to human health.
The Journal of nutrition 1999;129(3):758S-767S.
1999: Pietro Invernizzi; Kenneth D R Setchell; Andrea Crosignani; Pier Maria Battezzati; Alberto Larghi; N C O'Connell; Mauro Podda
Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1999;29(2):320-7.
1998: Kenneth D R Setchell; Linda Zimmer-Nechemias; J Cai; James Heubi
Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.
The American journal of clinical nutrition 1998;68(6 Suppl):1453S-1461S.
1998: Kenneth D R Setchell
Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.
The American journal of clinical nutrition 1998;68(6 Suppl):1333S-1346S.
1998: Kenneth D R Setchell; Margrit Schwarz; N C O'Connell; Erik G Lund; D L Davis; Richard Lathe; H R Thompson; R Weslie Tyson; Robert J Sokol; David W Russell
Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.
The Journal of clinical investigation 1998;102(9):1690-703.
1997: M Messina; S Barnes; Kenneth D R Setchell
Phyto-oestrogens and breast cancer.
Lancet 1997;350(9083):971-2.
1997: Kenneth D R Setchell; Linda Zimmer-Nechemias; J Cai; James Heubi
Exposure of infants to phyto-oestrogens from soy-based infant formula.
Lancet 1997;350(9070):23-7.
1997: Pietro Invernizzi; Andrew L Salzman; Csaba Szabó; I Ueta; M O'Connor; Kenneth D R Setchell
Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo.
The American journal of physiology 1997;273(1 Pt 1):G131-8.
1997: Kenneth D R Setchell; C M Rodrigues; Carlo Clerici; A Solinas; Antonio Morelli; C Gartung; J Boyer
Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei.
Gastroenterology 1997;112(1):226-35.
1996: Margrit Schwarz; Erik G Lund; Kenneth D R Setchell; H J Kayden; Joseph E Zerwekh; I Björkhem; Joachim Herz; David W Russell
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
The Journal of biological chemistry 1996;271(30):18024-31.
1996: Carlo Clerici; Kenneth D R Setchell; N O'Connell; Giorgio Gentili; G Rusticali; F Aversa; S Balo'; R Modesto; Antonio Maria Morselli-Labate; M Martelli; Antonio Morelli
Effect of ursodeoxycholic acid on hypertransaminasaemia and bile acid composition in patients undergoing bone marrow transplantation--a double-blind randomized control study.
The Italian journal of gastroenterology 1996;28(4):191-8.
1996: Andrea Crosignani; Kenneth D R Setchell; Pietro Invernizzi; Alberto Larghi; Cecília M P Rodrigues; Mauro Podda
Clinical pharmacokinetics of therapeutic bile acids.
Clinical pharmacokinetics 1996;30(5):333-58.
1996: Andrea Crosignani; Pier Maria Battezzati; Kenneth D R Setchell; Pietro Invernizzi; G Covini; Massimo Zuin; Mauro Podda
Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study.
Digestive diseases and sciences 1996;41(4):809-15.
1996: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Formation of delta 22-bile acids in rats is not gender specific and occurs in the peroxisome.
Journal of lipid research 1996;37(3):540-50.
1996: Kenneth D R Setchell; Cecília M P Rodrigues; Mauro Podda; Andrea Crosignani
Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis.
Gut 1996;38(3):439-46.
1996: Cecília M P Rodrigues; Kenneth D R Setchell
Performance characteristics of reversed-phase bonded silica cartridges for serum bile acid extraction.
Biomedical chromatography : BMC 1996;10(1):1-5.
1995: Betsy T Kren; Cecília M P Rodrigues; Kenneth D R Setchell; Clifford J Steer
Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding.
The American journal of physiology 1995;269(6 Pt 1):G961-73.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation.
Gastroenterology 1995;109(6):1835-44.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate.
Gastroenterology 1995;109(2):564-72.
1995: Kenneth D R Setchell; H Yamashita; Cecília M P Rodrigues; N C O'Connell; Betsy T Kren; Clifford J Steer
delta 22-Ursodeoxycholic acid, a unique metabolite of administered ursodeoxycholic acid in rats, indicating partial beta-oxidation as a major pathway for bile acid metabolism.
Biochemistry 1995;34(13):4169-78.
1994: R Dumaswala; D Berkowitz; Kenneth D R Setchell; James Heubi
Effect of fasting on the enterohepatic circulation of bile acids in rats.
The American journal of physiology 1994;267(5 Pt 1):G836-42.
1993: Carlo Clerici; Giorgio Gentili; G Dozzini; Eleonora Distrutti; A Solinas; A Vedovelli; Maria A Pelli; P Bragetti; Kenneth D R Setchell; Antonio Morelli
[Chronic therapy with ursodeoxycholic acid in a child with Alagille syndrome].
La Pediatria medica e chirurgica : Medical and surgical pediatrics 1993;15(5):521-3.
1993: R Dumaswala; Kenneth D R Setchell; M Susan Moyer; Frederick J Suchy
An anion exchanger mediates bile acid transport across the placental microvillous membrane.
The American journal of physiology 1993;264(6 Pt 1):G1016-23.
1992: C Colombo; Andrea Crosignani; M Assaisso; Pier Maria Battezzati; Mauro Podda; Annamaria Giunta; Linda Zimmer-Nechemias; Kenneth D R Setchell
Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose-response study.
Hepatology (Baltimore, Md.) 1992;16(4):924-30.
1992: James Heubi; N C O'Connell; Kenneth D R Setchell
Ileal resection/dysfunction in childhood predisposes to lithogenic bile only after puberty.
Gastroenterology 1992;103(2):636-40.
1992: David W Russell; Kenneth D R Setchell
Bile acid biosynthesis.
Biochemistry 1992;31(20):4737-49.
1992: Kenneth D R Setchell; P Bragetti; Linda Zimmer-Nechemias; C Daugherty; M A Pelli; R Vaccaro; G Gentili; Eleonora Distrutti; G Dozzini; Antonio Morelli
Oral bile acid treatment and the patient with Zellweger syndrome.
Hepatology (Baltimore, Md.) 1992;15(2):198-207.
1991: Andrea Crosignani; Mauro Podda; Pier Maria Battezzati; E Bertolini; Massimo Zuin; D Watson; Kenneth D R Setchell
Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration.
Hepatology (Baltimore, Md.) 1991;14(6):1000-7.
1991: D Watson; Kenneth D R Setchell; R Ross
Analysis of vitamin D and its metabolites using thermospray liquid chromatography/mass spectrometry.
Biomedical chromatography : BMC 1991;5(4):153-60.
1991: Andrea Crosignani; Mauro Podda; E Bertolini; Pier Maria Battezzati; Massimo Zuin; Kenneth D R Setchell
Failure of ursodeoxycholic acid to prevent a cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: a study of bile acid metabolism.
Hepatology (Baltimore, Md.) 1991;13(6):1076-83.
1991: Andrea Crosignani; Pier Maria Battezzati; Kenneth D R Setchell; M Camisasca; E Bertolini; A Roda; Massimo Zuin; Mauro Podda
Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: a dose-response study.
Hepatology (Baltimore, Md.) 1991;13(2):339-44.
1990: C Colombo; Kenneth D R Setchell; Mauro Podda; Andrea Crosignani; A Roda; L Curcio; M Ronchi; Annamaria Giunta
Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis.
The Journal of pediatrics 1990;117(3):482-9.
1990: M Nakagawa; C Colombo; Kenneth D R Setchell
Comprehensive study of the biliary bile acid composition of patients with cystic fibrosis and associated liver disease before and after UDCA administration.
Hepatology (Baltimore, Md.) 1990;12(2):322-34.
1990: M Nakagawa; Kenneth D R Setchell
Bile acid metabolism in early life: studies of amniotic fluid.
Journal of lipid research 1990;31(6):1089-98.
1989: R J Barbuch; J E Coutant; M B Welsh; Kenneth D R Setchell
The use of thermospray liquid chromatography/tandem mass spectrometry for the class identification and structural verification of phytoestrogens in soy protein preparations.
Biomedical & environmental mass spectrometry 1989;18(11):973-7.
1989: Kenneth D R Setchell; C H Vestal
Thermospray ionization liquid chromatography-mass spectrometry: a new and highly specific technique for the analysis of bile acids.
Journal of lipid research 1989;30(9):1459-69.
1989: R Dumaswala; Kenneth D R Setchell; Linda Zimmer-Nechemias; T Iida; J Goto; T Nambara
Identification of 3 alpha,4 beta,7 alpha-trihydroxy-5 beta-cholanoic acid in human bile: reflection of a new pathway in bile acid metabolism in humans.
Journal of lipid research 1989;30(6):847-56.
1988: Kenneth D R Setchell; Frederick J Suchy; M B Welsh; Linda Zimmer-Nechemias; James Heubi; William F Balistreri
Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis.
The Journal of clinical investigation 1988;82(6):2148-57.
1988: Kenneth D R Setchell; R Dumaswala; C Colombo; M Ronchi
Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile.
The Journal of biological chemistry 1988;263(32):16637-44.
1988: S J Gosselin; D L Loudy; M J Tarr; William F Balistreri; Kenneth D R Setchell; J O Johnston; L W Kramer; B L Dresser
Veno-occlusive disease of the liver in captive cheetah.
Veterinary pathology 1988;25(1):48-57.
1987: Kenneth D R Setchell; S J Gosselin; M B Welsh; J O Johnston; William F Balistreri; L W Kramer; B L Dresser; M J Tarr
Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahs.
Gastroenterology 1987;93(2):225-33.
1987: Kenneth D R Setchell; M B Welsh; C K Lim
High-performance liquid chromatographic analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical and thermospray mass spectrometric detection.
Journal of chromatography 1987;386():315-23.
1987: Kenneth D R Setchell; M B Welsh; M J Klooster; W F Balistreri; C K Lim
Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function.
Journal of chromatography 1987;385():267-74.