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Mohammad Reza Ahmadian
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Research Profile (preview)
Chemicals & Drugs
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21
Wittinghofer, Alfred
12
Scheffzek, Klaus
9
Dvorsky, Radovan
8
Herbrand, Ulrike
8
Stege, Patricia
7
Blumenstein, Lars
4
Goody, Roger
4
Fiegen, Dennis
4
Haeusler, Lars Christian
3
Hemsath, Lars
3
Eberth, Alexander
3
Vetter, Ingrid
3
Kabsch, W
2
Gremer, Lothar
2
Herrmann, Christian
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Geonetwork of Mohammad Reza Ahmadian (preview)
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All Publications
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2008: Gremer Lothar; Gilsbach Bernd; Ahmadian Mohammad Reza; Wittinghofer Alfred
Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.
Biological chemistry 2008;389(9):1163-71.
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2008: Gasper Raphael; Thomas Christoph; Ahmadian Mohammad Reza; Wittinghofer Alfred
The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.
Journal of molecular biology 2008;379(1):51-63.
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2008: Pena Vladimir; Hothorn Michael; Eberth Alexander; Kaschau Nikolai; Parret Annabel; Gremer Lothar; Bonneau Fabien; Ahmadian Mohammad Reza; Scheffzek Klaus
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.
EMBO reports 2008;9(4):350-5.
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2007: van der Burgt Ineke; Kupsky William; Stassou Stephani; Nadroo Ali; Barroso Cândida; Diem Angelika; Kratz Christian P; Dvorsky Radovan; Ahmadian Mohammad Reza; Zenker Martin
Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.
Journal of medical genetics 2007;44(7):459-62.
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2007: Gotthardt Katja; Ahmadian Mohammad Reza
Asef is a Cdc42-specific guanine nucleotide exchange factor.
Biological chemistry 2007;388(1):67-71.
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2007: Olsen Heidrun; ter Veld Frank; Herbrand Ulrike; Ahmadian Mohammad R; Kinne Rolf K-H; Wehner Frank
Differential regulation of cell volume and shape in confluent rat hepatocytes under hypertonic stress.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;19(5-6):259-68.
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2006: Herbrand Ulrike; Ahmadian Mohammad Reza
p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho.
Biological chemistry 2006;387(3):311-7.
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2006: Haeusler Lars Christian; Hemsath Lars; Fiegen Dennis; Blumenstein Lars; Herbrand Ulrike; Stege Patricia; Dvorsky Radovan; Ahmadian Mohammad Reza
Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b.
Methods in enzymology 2006;406():1-11.
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2005: Scheffzek K; Ahmadian M R
GTPase activating proteins: structural and functional insights 18 years after discovery.
Cellular and molecular life sciences : CMLS 2005;62(24):3014-38.
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2005: Eberth Alexander; Dvorsky Radovan; Becker Christian F W; Beste Andrea; Goody Roger S; Ahmadian Mohammad Reza
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins.
Biological chemistry 2005;386(11):1105-14.
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2005: Guo Zhong; Ahmadian Mohammad Reza; Goody Roger S
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism.
Biochemistry 2005;44(47):15423-9.
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2005: Hemsath Lars; Ahmadian Mohammad R
Fluorescence approaches for monitoring interactions of Rho GTPases with nucleotides, regulators, and effectors.
Methods (San Diego, Calif.) 2005;37(2):173-82.
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2005: Hemsath Lars; Dvorsky Radovan; Fiegen Dennis; Carlier Marie-France; Ahmadian Mohammad Reza
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
Molecular cell 2005;20(2):313-24.
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2005: Rose R; Weyand M; Lammers M; Ishizaki T; Ahmadian M R; Wittinghofer A
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Nature 2005;435(7041):513-8.
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2004: Dvorsky Radovan; Ahmadian Mohammad Reza
Always look on the bright site of Rho: structural implications for a conserved intermolecular interface.
EMBO reports 2004;5(12):1130-6.
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2004: Blumenstein Lars; Ahmadian Mohammad Reza
Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.
The Journal of biological chemistry 2004;279(51):53419-26.
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2004: Blöchl Andrea; Blumenstein Lars; Ahmadian Mohammad R
Inactivation and activation of Ras by the neurotrophin receptor p75.
The European journal of neuroscience 2004;20(9):2321-35.
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2004: Uhlenbrock Katharina; Eberth Alexander; Herbrand Ulrike; Daryab Neda; Stege Patricia; Meier Friedegund; Friedl Peter; Collard John G; Ahmadian Mohammad Reza
The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.
Journal of cell science 2004;117(Pt 20):4863-71.
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2004: Dvorsky Radovan; Blumenstein Lars; Vetter Ingrid R; Ahmadian Mohammad Reza
Structural insights into the interaction of ROCKI with the switch regions of RhoA.
The Journal of biological chemistry 2004;279(8):7098-104.
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2004: Fiegen Dennis; Haeusler Lars-Christian; Blumenstein Lars; Herbrand Ulrike; Dvorsky Radovan; Vetter Ingrid R; Ahmadian Mohammad R
Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase.
The Journal of biological chemistry 2004;279(6):4743-9.
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2003: Haeusler Lars Christian; Blumenstein Lars; Stege Patricia; Dvorsky Radovan; Ahmadian Mohammad Reza
Comparative functional analysis of the Rac GTPases.
FEBS letters 2003;555(3):556-60.
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2003: Fauchereau Fabien; Herbrand Ulrike; Chafey Philippe; Eberth Alexander; Koulakoff Annette; Vinet Marie-Claude; Ahmadian Mohammad Reza; Chelly Jamel; Billuart Pierre
The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.
Molecular and cellular neurosciences 2003;23(4):574-86.
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2003: Ahmadian Mohammad Reza; Kiel Christina; Stege Patricia; Scheffzek Klaus
Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.
Journal of molecular biology 2003;329(4):699-710.
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2003: Tiede Imke; Fritz Gerhard; Strand Susanne; Poppe Daniela; Dvorsky Radovan; Strand Dennis; Lehr Hans Anton; Wirtz Stefan; Becker Christoph; Atreya Raja; Mudter Jonas; Hildner Kai; Bartsch Brigitte; Holtmann Martin; Blumberg Richard; Walczak Henning; Iven Heiko; Galle Peter R; Ahmadian Mohammad Reza; Neurath Markus F
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.
The Journal of clinical investigation 2003;111(8):1133-45.
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2002: Fiegen Dennis; Blumenstein Lars; Stege Patricia; Vetter Ingrid R; Ahmadian Mohammad Reza
Crystal structure of Rnd3/RhoE: functional implications.
FEBS letters 2002;525(1-3):100-4.
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2002: Brinkmann Thilo; Daumke Oliver; Herbrand Ulrike; Kühlmann Dorothee; Stege Patricia; Ahmadian Mohammad Reza; Wittinghofer Alfred
Rap-specific GTPase activating protein follows an alternative mechanism.
The Journal of biological chemistry 2002;277(15):12525-31.
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2002: Karaguni Ioanna-Maria; Herter Peter; Debruyne Philip; Chtarbova Slava; Kasprzynski Alice; Herbrand Ulrike; Ahmadian M-Reza; Glüsenkamp Karl-Heinz; Winde Günther; Mareel Marc; Möröy Tarik; Müller Oliver
The new sulindac derivative IND 12 reverses Ras-induced cell transformation.
Cancer research 2002;62(6):1718-23.
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2002: Ahmadian Mohammad Reza; Wittinghofer Alfred; Schmidt Gudula
The actin filament architecture: tightly regulated by the cells, manipulated by pathogens. International Titisee Conference on the actin cytoskeleton: from signalling to bacterial pathogenesis.
EMBO reports 2002;3(3):214-8.
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2002: Ahmadian Mohammad Reza
Prospects for anti-ras drugs.
British journal of haematology 2002;116(3):511-8.
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2002: Ahmadian Mohammad Reza; Wittinghofer Alfred; Herrmann Christian
Fluorescence methods in the study of small GTP-binding proteins.
Methods in molecular biology (Clifton, N.J.) 2002;189():45-63.
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2001: Gail R; Costisella B; Ahmadian M R; Wittinghofer A
Ras-mediated cleavage of a GTP analogue by a novel mechanism.
Chembiochem : a European journal of chemical biology 2001;2(7-8):570-5.
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2001: Allin C; Ahmadian M R; Wittinghofer A; Gerwert K
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7754-9.
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2001: Demunter A; Ahmadian M R; Libbrecht L; Stas M; Baens M; Scheffzek K; Degreef H; De Wolf-Peeters C; van Den Oord J J
A novel N-ras mutation in malignant melanoma is associated with excellent prognosis.
Cancer research 2001;61(12):4916-22.
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2001: van Horck F P; Ahmadian M R; Haeusler L C; Moolenaar W H; Kranenburg O
Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.
The Journal of biological chemistry 2001;276(7):4948-56.
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2001: Würtele M; Wolf E; Pederson K J; Buchwald G; Ahmadian M R; Barbieri J T; Wittinghofer A
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac.
Nature structural biology 2001;8(1):23-6.
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2000: Klockow B; Ahmadian M R; Block C; Wittinghofer A
Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling.
Oncogene 2000;19(47):5367-76.
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1999: Reid T; Bathoorn A; Ahmadian M R; Collard J G
Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.
The Journal of biological chemistry 1999;274(47):33587-93.
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1999: Ahmadian M R; Zor T; Vogt D; Kabsch W; Selinger Z; Wittinghofer A; Scheffzek K
Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7065-70.
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1998: Scheffzek K; Ahmadian M R; Wiesmüller L; Kabsch W; Stege P; Schmitz F; Wittinghofer A
Structural analysis of the GAP-related domain from neurofibromin and its implications.
The EMBO journal 1998;17(15):4313-27.
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1998: Klose A; Ahmadian M R; Schuelke M; Scheffzek K; Hoffmeyer S; Gewies A; Schmitz F; Kaufmann D; Peters H; Wittinghofer A; Nürnberg P
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.
Human molecular genetics 1998;7(8):1261-8.
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1998: Scheffzek K; Ahmadian M R; Wittinghofer A
GTPase-activating proteins: helping hands to complement an active site.
Trends in biochemical sciences 1998;23(7):257-62.
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1998: Herrmann C; Ahmadian M R; Hofmann F; Just I
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.
The Journal of biological chemistry 1998;273(26):16134-9.
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1997: Ahmadian M R; Stege P; Scheffzek K; Wittinghofer A
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.
Nature structural biology 1997;4(9):686-9.
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1997: Scheffzek K; Ahmadian M R; Kabsch W; Wiesmüller L; Lautwein A; Schmitz F; Wittinghofer A
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science (New York, N.Y.) 1997;277(5324):333-8.
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1997: Wittinghofer A; Scheffzek K; Ahmadian M R
The interaction of Ras with GTPase-activating proteins.
FEBS letters 1997;410(1):63-7.
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1997: Ahmadian M R; Mittal R; Hall A; Wittinghofer A
Aluminum fluoride associates with the small guanine nucleotide binding proteins.
FEBS letters 1997;408(3):315-8.
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1997: Ahmadian M R; Hoffmann U; Goody R S; Wittinghofer A
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy.
Biochemistry 1997;36(15):4535-41.
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1996: Scheffzek K; Lautwein A; Kabsch W; Ahmadian M R; Wittinghofer A
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature 1996;384(6609):591-6.
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1996: Ahmadian M R; Wiesmüller L; Lautwein A; Bischoff F R; Wittinghofer A
Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin.
The Journal of biological chemistry 1996;271(27):16409-15.
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1996: Mittal R; Ahmadian M R; Goody R S; Wittinghofer A
Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins.
Science (New York, N.Y.) 1996;273(5271):115-7.
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