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Gautam Sethi

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Rahul Checker; S Jayakumar; Vineet Kohli; Raghavendra S Patwardhan; Santosh K Sandur; Gautam Sethi; Deepak Sharma; Bharat B Aggarwal; Krishna B Sainis
Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.
Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Gautam Sethi; Parmeswaran Diagaradjane; Preetha Anand; Manoj Pandey; Juri G Gelovani; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Preetha Anand; Sushovan Guha; Bharat B Aggarwal
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.

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All Publications

2012: Rahul Checker; S Jayakumar; Vineet Kohli; Raghavendra S Patwardhan; Santosh K Sandur; Gautam Sethi; Deepak Sharma; Bharat B Aggarwal; Krishna B Sainis
Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.
PloS one 2012;7(2):e31318.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Gautam Sethi; Parmeswaran Diagaradjane; Preetha Anand; Manoj Pandey; Juri G Gelovani; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
International journal of cancer. Journal international du cancer 2010;127(2):257-68.
2009: Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Preetha Anand; Sushovan Guha; Bharat B Aggarwal
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Molecular cancer therapeutics 2009;8(4):959-70.
2009: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Advances in experimental medicine and biology 2009;647():207-15.
2009: Gautam Sethi; Bokyung Sung; Ajaikumar B Kunnumakkara; Bharat B Aggarwal
Targeting TNF for Treatment of Cancer and Autoimmunity.
Advances in experimental medicine and biology 2009;647():37-51.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Kwang Seok Ahn; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2008;123(8):1733-40.
2008: Manoj Pandey; Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Chandra Iyer; Astrid Kosters; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal; James Versalovic
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
Cellular microbiology 2008;10(7):1442-52.
2008: Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.
Molecular cancer research : MCR 2008;6(6):1059-70.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Bharat B Aggarwal
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Molecular cancer therapeutics 2008;7(6):1604-14.
2008: Kwang Seok Ahn; Gautam Sethi; Bokyung Sung; Ajay Goel; Ranju Ralhan; Bharat B Aggarwal
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Cancer research 2008;68(11):4406-15.
2008: Yasunari Takada; Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Molecular pharmacology 2008;73(5):1549-57.
2008: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.
Biochemical pharmacology 2008;75(4):907-13.
2008: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
TNF: a master switch for inflammation to cancer.
Frontiers in bioscience : a journal and virtual library 2008;13():5094-107.
2007: Gautam Sethi; Kwang Seok Ahn; Madan M Chaturvedi; Bharat B Aggarwal
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Oncogene 2007;26(52):7324-32.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Nuclear factor-kappa B: from clone to clinic.
Current molecular medicine 2007;7(7):619-37.
2007: Amit Deorukhkar; Sunil Krishnan; Gautam Sethi; Bharat B Aggarwal
Back to basics: how natural products can provide the basis for new therapeutics.
Expert opinion on investigational drugs 2007;16(11):1753-73.
2007: Kwang Seok Ahn; Xing Gong; Gautam Sethi; Madan M Chaturvedi; Anil K Jaiswal; Bharat B Aggarwal
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Cancer research 2007;67(20):10004-11.
2007: Bharat B Aggarwal; Gautam Sethi; Veera Baladandayuthapani; Sunil Krishnan; Shishir Shishodia
Targeting cell signaling pathways for drug discovery: an old lock needs a new key.
Journal of cellular biochemistry 2007;102(3):580-92.
2007: Yasunari Takada; Bokyung Sung; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
Biochemical pharmacology 2007;74(7):1057-64.
2007: Kwang Seok Ahn; Gautam Sethi; Ta-Hsiang Chao; Saskia T C Neuteboom; Madan M Chaturvedi; Michael A Palladino; Anas Younes; Bharat B Aggarwal
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood 2007;110(7):2286-95.
2007: Ashutosh K Pathak; Manisha Bhutani; Asha S Nair; Kwang Seok Ahn; Arup Chakraborty; Humam Kadara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Molecular cancer research : MCR 2007;5(9):943-55.
2007: Santosh K Sandur; Haruyo Ichikawa; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Gautam Sethi; Bharat B Aggarwal
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Free radical biology & medicine 2007;43(4):568-80.
2007: Gautam Sethi; Kwang Seok Ahn; Dianren Xia; Jonathan M Kurie; Bharat B Aggarwal
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1926-33.
2007: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Akira Murakami; Gautam Sethi; Pornngarm Limtrakul; Vladimir Badmaev; Bharat B Aggarwal
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Carcinogenesis 2007;28(8):1765-73.
2007: Gautam Sethi; Bharat B Aggarwal
Mending the bones with natural products.
Chemistry & biology 2007;14(7):738-40.
2007: Shishir Shishodia; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Biochemical pharmacology 2007;74(1):118-30.
2007: Manoj Pandey; Santosh K Sandur; Bokyung Sung; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
The Journal of biological chemistry 2007;282(24):17340-50.
2007: Dinesh Khanna; Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Amita Aggarwal; Bharat B Aggarwal
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Manisha Bhutani; Ashutosh K Pathak; Asha S Nair; Ajaikumar Kunnumakkara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3024-32.
2007: Sunil K Manna; Rishi S Aggarwal; Gautam Sethi; Bharat B Aggarwal; Govindarajan T Ramesh
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2290-7.
2007: Bharat B Aggarwal; Sanjeev Banerjee; Uddalak Bharadwaj; Bokyung Sung; Shishir Shishodia; Gautam Sethi
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Biochemical pharmacology 2007;73(7):1024-32.
2007: Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Bharat B Aggarwal
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
Blood 2007;109(7):2727-35.
2007: Anjana Bhardwaj; Gautam Sethi; Saroj Vadhan-Raj; Carlos E Bueso-Ramos; Yasunari Takada; Upasna Gaur; Asha S Nair; Shishir Shishodia; Bharat B Aggarwal
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Blood 2007;109(6):2293-302.
2007: Ashish M Kamat; Gautam Sethi; Bharat B Aggarwal
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
Molecular cancer therapeutics 2007;6(3):1022-30.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2507-16.
2007: Kwang Seok Ahn; Gautam Sethi; Koyamangalath Krishnan; Bharat B Aggarwal
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
The Journal of biological chemistry 2007;282(1):809-20.
2007: Santosh K Sandur; Kwang Seok Ahn; Haruyo Ichikawa; Gautam Sethi; Shishir Shishodia; Robert A Newman; Bharat B Aggarwal
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
Nutrition and cancer 2007;57(1):78-87.
2007: Prachi Garodia; Haruyo Ichikawa; Nikita Malani; Gautam Sethi; Bharat B Aggarwal
From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.
Journal of the Society for Integrative Oncology 2007;5(1):25-37.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology 2007;71(1):209-19.
2006: Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Bharat B Aggarwal; Shishir Shishodia; Santosh K Sandur; Manoj Pandey; Gautam Sethi
Inflammation and cancer: how hot is the link?
Biochemical pharmacology 2006;72(11):1605-21.
2006: Asha S Nair; Shishir Shishodia; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Gautam Sethi; Bharat B Aggarwal
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5612-22.
2006: Kwang Seok Ahn; Gautam Sethi; Shishir Shishodia; Bokyung Sung; Jack L Arbiser; Bharat B Aggarwal
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Molecular cancer research : MCR 2006;4(9):621-33.
2006: Aman P Mann; Amit Verma; Gautam Sethi; Bramanandam Manavathi; Huamin Wang; Jansina Y Fok; Ajaikumar Kunnumakkara; Rakesh Kumar; Bharat B Aggarwal; Kapil Mehta
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
Cancer research 2006;66(17):8788-95.
2006: Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Xin Lin; Madan M Chaturvedi; Bharat B Aggarwal
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
The Journal of biological chemistry 2006;281(33):23425-35.
2006: Kwang Seok Ahn; Gautam Sethi; Abhinav K Jain; Anil K Jaiswal; Bharat B Aggarwal
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
The Journal of biological chemistry 2006;281(29):19798-808.
2006: Santosh K Sandur; Haruyo Ichikawa; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
The Journal of biological chemistry 2006;281(25):17023-33.
2006: Shishir Shishodia; Gautam Sethi; Marina Konopleva; Michael Andreeff; Bharat B Aggarwal
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1828-38.
2006: Bharat B Aggarwal; Haruyo Ichikawa; Prachi Garodia; Priya Weerasinghe; Gautam Sethi; Indra D Bhatt; Manoj Pandey; Shishir Shishodia; Muraleedharan G Nair
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.
Expert opinion on therapeutic targets 2006;10(1):87-118.
2005: Shishir Shishodia; Gautam Sethi; Bharat B Aggarwal
Curcumin: getting back to the roots.
Annals of the New York Academy of Sciences 2005;1056():206-17.