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Tariq Sethi

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Alison C Mackinnon; Mark R Miller; David E Newby; Patrick Wf Hadoke; Xiaojun Liu; Tariq Sethi
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice.
Alison C Mackinnon; Ulf J Nilsson; A John Simpson; Tamara Delaine; Sarah L Farnworth; Stuart J Forbes; Jack Gauldie; Michael A Gibbons; Nik Hirani; Hakon Leffler; Tariq Sethi
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.
Brian J McHugh; Amanda Murdoch; Christopher Haslett; Tariq Sethi
Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration.

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All Publications

2013: Alison C Mackinnon; Mark R Miller; David E Newby; Patrick Wf Hadoke; Xiaojun Liu; Tariq Sethi
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice.
Glycobiology 2013;23(6):654-63.
2012: Alison C Mackinnon; Ulf J Nilsson; A John Simpson; Tamara Delaine; Sarah L Farnworth; Stuart J Forbes; Jack Gauldie; Michael A Gibbons; Nik Hirani; Hakon Leffler; Tariq Sethi
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.
American journal of respiratory and critical care medicine 2012;185(5):537-46.
2012: Brian J McHugh; Amanda Murdoch; Christopher Haslett; Tariq Sethi
Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration.
PloS one 2012;7(7):e40346.
2010: Alison C Mackinnon; Jens Kopatz; Tariq Sethi
The molecular and cellular biology of lung cancer: identifying novel therapeutic strategies.
British medical bulletin 2010;95():47-61.
2010: Brian J McHugh; Robert C Buttery; Yatish Lad; Stephen Banks; Christopher Haslett; Tariq Sethi
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum.
Journal of cell science 2010;123(Pt 1):51-61.
2009: Neil C Henderson; Tariq Sethi
The regulation of inflammation by galectin-3.
Immunological reviews 2009;230(1):160-71.
2009: Ingrid E Dumitriu; Donald R Dunbar; Sarah E M Howie; Tariq Sethi; Christopher D Gregory
Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2795-807.
2009: Alison C Mackinnon; Uzma Tufail-Hanif; Mark Wheatley; Adriano G Rossi; Christopher Haslett; Michael Seckl; Tariq Sethi
Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.
British journal of pharmacology 2009;156(1):36-47.
2008: Philip S Hodkinson; Alison Mackinnon; Tariq Sethi
Targeting growth factors in lung cancer.
Chest 2008;133(5):1209-16.
2008: Alison C Mackinnon; Sarah L Farnworth; Philip S Hodkinson; Neil C Henderson; Kirsten M Atkinson; Hakon Leffler; Ulf J Nilsson; Christopher Haslett; Stuart J Forbes; Tariq Sethi
Regulation of alternative macrophage activation by galectin-3.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2650-8.
2008: Sarah L Farnworth; Neil C Henderson; Alison C Mackinnon; Kirsten M Atkinson; Tom Wilkinson; Kevin Dhaliwal; Katsutoshi Hayashi; A John Simpson; Adriano G Rossi; Christopher Haslett; Tariq Sethi
Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.
The American journal of pathology 2008;172(2):395-405.
2008: Neil C Henderson; Alison C Mackinnon; Sarah L Farnworth; Tiina Kipari; Christopher Haslett; John P Iredale; Fu-Tong Liu; Jeremy Hughes; Tariq Sethi
Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.
The American journal of pathology 2008;172(2):288-98.
2007: Philip S Hodkinson; Alison C Mackinnon; Tariq Sethi
Extracellular matrix regulation of drug resistance in small-cell lung cancer.
International journal of radiation biology 2007;83(11-12):733-41.
2007: Philip S Hodkinson; Paul A Elliott; Yatish Lad; Brian J McHugh; Alison C Mackinnon; Christopher Haslett; Tariq Sethi
Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
The Journal of biological chemistry 2007;282(39):28991-9001.
2007: Neil C Henderson; Katharine J Pollock; John Frew; Alison C Mackinnon; Richard A Flavell; Roger J Davis; Tariq Sethi; Kenneth J Simpson
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Gut 2007;56(7):982-90.
2006: Yatish Lad; Brian McHugh; Philip S Hodkinson; Alison C Mackinnon; Christopher Haslett; Mark H Ginsberg; Tariq Sethi
Phospholipase C epsilon suppresses integrin activation.
The Journal of biological chemistry 2006;281(40):29501-12.
2006: Philip S Hodkinson; T Elliott; W S Wong; Robert C Rintoul; Alison C Mackinnon; Christopher Haslett; Tariq Sethi
ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase.
Cell death and differentiation 2006;13(10):1776-88.
2006: Neil C Henderson; Alison C Mackinnon; Sarah L Farnworth; Francoise Poirier; Francesco P Russo; John P Iredale; Christopher Haslett; Kenneth J Simpson; Tariq Sethi
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):5060-5.
2005: Alison C Mackinnon; Uzma Tufail-Hanif; C D Lucas; Duncan I Jodrell; Christopher Haslett; Tariq Sethi
Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition.
British journal of cancer 2005;92(3):522-31.
2004: Neil C Henderson; Elizabeth A Collis; Alison C Mackinnon; Kenneth J Simpson; Christopher Haslett; Roy Zent; Mark Ginsberg; Tariq Sethi
CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.
The Journal of biological chemistry 2004;279(52):54731-41.
2004: Philip N Newsome; John Tsiaoussis; Steven Masson; Robert C Buttery; Cameron Livingston; Ian Ansell; James A Ross; Tariq Sethi; Peter C Hayes; john plevris
Serum from patients with fulminant hepatic failure causes hepatocyte detachment and apoptosis by a beta(1)-integrin pathway.
Hepatology (Baltimore, Md.) 2004;40(3):636-45.
2004: Robert C Buttery; Robert C Rintoul; Tariq Sethi
Small cell lung cancer: the importance of the extracellular matrix.
The international journal of biochemistry & cell biology 2004;36(7):1154-60.
2004: Robert C Buttery; Hannah Monaghan; Donald Salter; Tariq Sethi
Galectin-3: differential expression between small-cell and non-small-cell lung cancer.
Histopathology 2004;44(4):339-44.
2003: C M Waters; Alison C Mackinnon; Jeff Cummings; Uzma Tufail-Hanif; Duncan I Jodrell; Christopher Haslett; Tariq Sethi
Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition.
British journal of cancer 2003;88(11):1808-16.
2003: Alison MacKinnon; Tariq Sethi
[D-Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism.
Methods in molecular medicine 2003;74():299-307.
2002: Alison C Mackinnon; Avril Buckley; Edwin R Chilvers; Adriano G Rossi; Christopher Haslett; Tariq Sethi
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6394-400.
2002: Tariq Sethi
Lung cancer. Introduction.
Thorax 2002;57(11):992-3.
2002: Robert C Rintoul; Tariq Sethi
The lung cancer paradox: time for action.
Thorax 2002;57 Suppl 2():II57-II63.
2002: Tony Elliott; Tariq Sethi
Integrins and extracellular matrix: a novel mechanism of multidrug resistance.
Expert review of anticancer therapy 2002;2(4):449-59.
2002: Robert C Rintoul; Robert C Buttery; Alison C Mackinnon; Weng Sie Wong; Deane Mosher; Christopher Haslett; Tariq Sethi
Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth.
Molecular biology of the cell 2002;13(8):2841-52.
2002: Robert C Rintoul; Tariq Sethi
Extracellular matrix regulation of drug resistance in small-cell lung cancer.
Clinical science (London, England : 1979) 2002;102(4):417-24.
2001: Alison C Mackinnon; C Waters; Duncan I Jodrell; Christopher Haslett; Tariq Sethi
Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism.
The Journal of biological chemistry 2001;276(30):28083-91.
2001: Robert C Rintoul; Tariq Sethi
The role of extracellular matrix in small-cell lung cancer.
The lancet oncology 2001;2(7):437-42.
2000: Beat Oertli; Jiahuai Han; B M Marte; Tariq Sethi; J Downward; M Ginsberg; Paul E Hughes
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oncogene 2000;19(43):4961-9.
2000: Alison C Mackinnon; C Waters; I Rahman; N Harani; Robert C Rintoul; Christopher Haslett; Tariq Sethi
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
British journal of cancer 2000;83(7):941-8.
1999: Tariq Sethi; Robert C Rintoul; SM Moore; Alison C Mackinnon; Donald Salter; C Choo; Edwin R Chilvers; Ian Dransfield; Seamas C Donnelly; R Strieter; Christopher Haslett
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo.
Nature medicine 1999;5(6):662-8.
1999: Alison C Mackinnon; R A Armstrong; C M Waters; Jeff Cummings; John F Smyth; Christopher Haslett; Tariq Sethi
[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism.
British journal of cancer 1999;80(7):1026-34.
1999: Tariq Sethi; Mark H Ginsberg; J Downward; Paul E Hughes
The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway.
Molecular biology of the cell 1999;10(6):1799-809.
1998: SM Moore; Robert C Rintoul; Trevor R Walker; Edwin R Chilvers; Christopher Haslett; Tariq Sethi
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.
Cancer research 1998;58(22):5239-47.
1997: Csilla Anne Fenczik; Tariq Sethi; Joe W Ramos; Paul E Hughes; Mark H Ginsberg
Complementation of dominant suppression implicates CD98 in integrin activation.
Nature 1997;390(6655):81-5.
1997: Tariq Sethi
Science, medicine, and the future. Lung cancer.
BMJ (Clinical research ed.) 1997;314(7081):652-5.
1996: A Tallett; Edwin R Chilvers; S Hannah; Ian Dransfield; M F Lawson; C Haslett; Tariq Sethi
Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.
Cancer research 1996;56(18):4255-63.
1996: A Tallett; Edwin R Chilvers; Alison C Mackinnon; C Haslett; Tariq Sethi
Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines.
Peptides 1996;17(4):665-73.
1994: Edwin R Chilvers; Tariq Sethi
How receptors work: mechanisms of signal transduction.
Postgraduate medical journal 1994;70(829):813-7.