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Jeffrey Settleman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Settleman Jeff
A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.
Xu Haiming; Eleswarapu Satyam; Geiger Hartmut; Szczur Kathleen; Daria Deidre; Zheng Yi; Settleman Jeffrey; Srour Edward F; Williams David A; Filippi Marie-Dominique
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Lévay Magdolna; Settleman Jeffrey; Ligeti Erzsébet
Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.

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All Publications

2009: Settleman Jeff
A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.
Cancer cell 2009;16(4):278-9.
2009: Xu Haiming; Eleswarapu Satyam; Geiger Hartmut; Szczur Kathleen; Daria Deidre; Zheng Yi; Settleman Jeffrey; Srour Edward F; Williams David A; Filippi Marie-Dominique
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood 2009;114(17):3557-66.
2009: Lévay Magdolna; Settleman Jeffrey; Ligeti Erzsébet
Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.
Biochemistry 2009;48(36):8615-23.
2009: Shaw Alice T; Yeap Beow Y; Mino-Kenudson Mari; Digumarthy Subba R; Costa Daniel B; Heist Rebecca S; Solomon Benjamin; Stubbs Hannah; Admane Sonal; McDermott Ultan; Settleman Jeffrey; Kobayashi Susumu; Mark Eugene J; Rodig Scott J; Chirieac Lucian R; Kwak Eunice L; Lynch Thomas J; Iafrate A John
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(26):4247-53.
2009: McDermott Ultan; Ames Rachel Y; Iafrate A John; Maheswaran Shyamala; Stubbs Hannah; Greninger Patricia; McCutcheon Kaitlin; Milano Randy; Tam Angela; Lee Diana Y; Lucien Laury; Brannigan Brian W; Ulkus Lindsey E; Ma Xiao-Jun; Erlander Mark G; Haber Daniel A; Sharma Sreenath V; Settleman Jeffrey
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.
Cancer research 2009;69(9):3937-46.
2009: Plentz Ruben; Park Ji-Sun; Rhim Andrew D; Abravanel Daniel; Hezel Aram F; Sharma Sreenath V; Gurumurthy Sushma; Deshpande Vikram; Kenific Candia; Settleman Jeffrey; Majumder Pradip K; Stanger Ben Z; Bardeesy Nabeel
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.
Gastroenterology 2009;136(5):1741-9.e6.
2009: Quinlan Margaret P; Settleman Jeffrey
Isoform-specific ras functions in development and cancer.
Future oncology (London, England) 2009;5(1):105-16.
2009: Sharma Sreenath V; Settleman Jeffrey
ErbBs in lung cancer.
Experimental cell research 2009;315(4):557-71.
2009: Bernards André; Settleman Jeffrey
Loss of the Ras regulator RASAL1: another route to Ras activation in colorectal cancer.
Gastroenterology 2009;136(1):46-8.
2009: Heckman-Stoddard Brandy M; Vargo-Gogola Tracy; McHenry Peter R; Jiang Vivian; Herrick Matthew P; Hilsenbeck Susan G; Settleman Jeffrey; Rosen Jeffrey M
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
Breast cancer research : BCR 2009;11(4):R61.
2008: Chin Tan Min; Quinlan Margaret P; Singh Anurag; Sequist Lecia V; Lynch Thomas J; Haber Daniel A; Sharma Sreenath V; Settleman Jeffrey
Reduced Erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6867-76.
2008: Shen Che-Hung; Chen Hsin-Yi; Lin Ming-Shien; Li Fang-Yen; Chang Cheng-Chi; Kuo Min-Liang; Settleman Jeffrey; Chen Ruey-Hwa
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.
Cancer research 2008;68(19):7779-87.
2008: Rothenberg S Michael; Engelman Jeffrey A; Le Sheila; Riese David J; Haber Daniel A; Settleman Jeffrey
Modeling oncogene addiction using RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12480-4.
2008: Quinlan Margaret P; Settleman Jeffrey
[A Kras-specific function in cancer initiation]
Ai zheng = Aizheng = Chinese journal of cancer 2008;27(7):673-4.
2008: Maheswaran Shyamala; Sequist Lecia V; Nagrath Sunitha; Ulkus Lindsey; Brannigan Brian; Collura Chey V; Inserra Elizabeth; Diederichs Sven; Iafrate A John; Bell Daphne W; Digumarthy Subba; Muzikansky Alona; Irimia Daniel; Settleman Jeffrey; Tompkins Ronald G; Lynch Thomas J; Toner Mehmet; Haber Daniel A
Detection of mutations in EGFR in circulating lung-cancer cells.
The New England journal of medicine 2008;359(4):366-77.
2008: Bell Daphne W; Brannigan Brian W; Matsuo Keitaro; Finkelstein Dianne M; Sordella Raffaella; Settleman Jeff; Mitsudomi Tetsuya; Haber Daniel A
Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4079-84.
2008: Jiang Wei; Betson Martha; Mulloy Roseann; Foster Rosemary; Lévay Magdolna; Ligeti Erzsébet; Settleman Jeffrey
p190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration.
The Journal of biological chemistry 2008;283(30):20978-88.
2008: Montagut Clara; Sharma Sreenath V; Shioda Toshi; McDermott Ultan; Ulman Matthew; Ulkus Lindsey E; Dias-Santagata Dora; Stubbs Hannah; Lee Diana Y; Singh Anurag; Drew Lisa; Haber Daniel A; Settleman Jeffrey
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.
Cancer research 2008;68(12):4853-61.
2008: Bass Mark D; Morgan Mark R; Roach Kirsty A; Settleman Jeffrey; Goryachev Andrew B; Humphries Martin J
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.
The Journal of cell biology 2008;181(6):1013-26.
2008: Baum Buzz; Settleman Jeffrey; Quinlan Margaret P
Transitions between epithelial and mesenchymal states in development and disease.
Seminars in cell & developmental biology 2008;19(3):294-308.
2008: Settleman Jeffrey; Baum Buzz
Cell shape and tissue morphogenesis.
Seminars in cell & developmental biology 2008;19(3):213-4.
2008: Gupta Pankaj; Emdad Luni; Lebedeva Irina V; Sarkar Devanand; Dent Paul; Curiel David T; Settleman Jeffrey; Fisher Paul B
Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.
Journal of cellular physiology 2008;215(3):827-36.
2008: Sequist Lecia V; Martins Renato G; Spigel David; Grunberg Steven M; Spira Alexander; Jänne Pasi A; Joshi Victoria A; McCollum David; Evans Tracey L; Muzikansky Alona; Kuhlmann Georgiana L; Han Moon; Goldberg Jonathan S; Settleman Jeffrey; Iafrate A John; Engelman Jeffrey A; Haber Daniel A; Johnson Bruce E; Lynch Thomas J
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(15):2442-9.
2008: McDermott Ultan; Iafrate A John; Gray Nathanael S; Shioda Toshi; Classon Marie; Maheswaran Shyamala; Zhou Wenjun; Choi Hwan Geun; Smith Shannon L; Dowell Lori; Ulkus Lindsey E; Kuhlmann Georgiana; Greninger Patricia; Christensen James G; Haber Daniel A; Settleman Jeffrey
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research 2008;68(9):3389-95.
2008: Quinlan Margaret P; Settleman Jeffrey
Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.
Cell cycle (Georgetown, Tex.) 2008;7(10):1332-5.
2008: Haigis Kevin M; Kendall Krystle R; Wang Yufang; Cheung Ann; Haigis Marcia C; Glickman Jonathan N; Niwa-Kawakita Michiko; Sweet-Cordero Alejandro; Sebolt-Leopold Judith; Shannon Kevin M; Settleman Jeffrey; Giovannini Marco; Jacks Tyler
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Nature genetics 2008;40(5):600-8.
2008: Godin-Heymann Nadia; Ulkus Lindsey; Brannigan Brian W; McDermott Ultan; Lamb Jennifer; Maheswaran Shyamala; Settleman Jeffrey; Haber Daniel A
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.
Molecular cancer therapeutics 2008;7(4):874-9.
2008: Quinlan Margaret P; Quatela Steven E; Philips Mark R; Settleman Jeffrey
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.
Molecular and cellular biology 2008;28(8):2659-74.
2008: Engelman Jeffrey A; Settleman Jeffrey
Acquired resistance to tyrosine kinase inhibitors during cancer therapy.
Current opinion in genetics & development 2008;18(1):73-9.
2008: Chen Guang-Chao; Lee Janice Y; Tang Hong-Wen; Debnath Jayanta; Thomas Sheila M; Settleman Jeffrey
Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.
Autophagy 2008;4(1):37-45.
2008: McDermott Ultan; Sharma Sreenath V; Settleman Jeffrey
High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.
Methods in enzymology 2008;438():331-41.
2007: Sharma Sreenath V; Settleman Jeffrey
Oncogene addiction: setting the stage for molecularly targeted cancer therapy.
Genes & development 2007;21(24):3214-31.
2007: McDermott Ultan; Sharma Sreenath V; Dowell Lori; Greninger Patricia; Montagut Clara; Lamb Jennifer; Archibald Heidi; Raudales Raul; Tam Angela; Lee Diana; Rothenberg S Michael; Supko Jeffrey G; Sordella Raffaella; Ulkus Lindsey E; Iafrate A John; Maheswaran Shyamala; Njauw Ching Ni; Tsao Hensin; Drew Lisa; Hanke Jeff H; Ma Xiao-Jun; Erlander Mark G; Gray Nathanael S; Haber Daniel A; Settleman Jeffrey
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19936-41.
2007: Bernards André; Settleman Jeffrey
GEFs in growth factor signaling.
Growth factors (Chur, Switzerland) 2007;25(5):355-61.
2007: Sfakianos Mindan K; Eisman Aaron; Gourley Shannon L; Bradley William D; Scheetz Alfred J; Settleman Jeffrey; Taylor Jane R; Greer Charles A; Williamson Anne; Koleske Anthony J
Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10982-92.
2007: Heckman Brandy M; Chakravarty Geetika; Vargo-Gogola Tracy; Gonzales-Rimbau Maria; Hadsell Darryl L; Lee Adrian V; Settleman Jeffrey; Rosen Jeffrey M
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Developmental biology 2007;309(1):137-49.
2007: Godin-Heymann Nadia; Bryant Ianthe; Rivera Miguel N; Ulkus Lindsey; Bell Daphne W; Riese David J; Settleman Jeffrey; Haber Daniel A
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.
Cancer research 2007;67(15):7319-26.
2007: Betson Martha; Settleman Jeffrey
A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.
Genetics 2007;176(4):2201-12.
2007: Settleman Jeffrey; Kurie Jonathan M
Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.
Cancer cell 2007;12(1):6-8.
2007: Riese David J; Gallo Richard M; Settleman Jeffrey
Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(6):558-65.
2007: Haber Daniel A; Settleman Jeff
Cancer: drivers and passengers.
Nature 2007;446(7132):145-6.
2007: Mulloy Roseann; Ferrand Audrey; Kim Youngjoo; Sordella Raffaella; Bell Daphne W; Haber Daniel A; Anderson Karen S; Settleman Jeffrey
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.
Cancer research 2007;67(5):2325-30.
2007: Sharma Sreenath V; Bell Daphne W; Settleman Jeffrey; Haber Daniel A
Epidermal growth factor receptor mutations in lung cancer.
Nature reviews. Cancer 2007;7(3):169-81.
2007: Emdad Luni; Lebedeva Irina V; Su Zao-Zhong; Gupta Pankaj; Sarkar Devanand; Settleman Jeffrey; Fisher Paul B
Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.
Journal of cellular physiology 2007;210(2):549-59.
2007: Settleman Jeffrey
PAK-in' up cGMP for the move.
Cell 2007;128(2):237-8.
2006: Sharma Sreenath V; Settleman Jeffrey
Oncogenic shock: turning an activated kinase against the tumor cell.
Cell cycle (Georgetown, Tex.) 2006;5(24):2878-80.
2006: Wildenberg Gregg A; Dohn Michael R; Carnahan Robert H; Davis Michael A; Lobdell Nichole A; Settleman Jeffrey; Reynolds Albert B
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
Cell 2006;127(5):1027-39.
2006: Sharma Sreenath V; Gajowniczek Patrycja; Way Inna P; Lee Diana Y; Jiang Jane; Yuza Yuki; Classon Marie; Haber Daniel A; Settleman Jeffrey
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
Cancer cell 2006;10(5):425-35.
2006: Bradley William D; Hernández Samuel E; Settleman Jeffrey; Koleske Anthony J
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Molecular biology of the cell 2006;17(11):4827-36.
2006: Hakre Shweta; Tussie-Luna María Isabel; Ashworth Todd; Novina Carl D; Settleman Jeffrey; Sharp Phillip A; Roy Ananda L
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
Molecular cell 2006;24(2):301-8.
2006: Verdier Valerie; Johndrow James E; Betson Martha; Chen Guang-Chao; Hughes David A; Parkhurst Susan M; Settleman Jeffrey
Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.
Developmental biology 2006;297(2):417-32.
2006: Sebastian Sinto; Settleman Jeffrey; Reshkin Stephan J; Azzariti Amalia; Bellizzi Antonia; Paradiso Angelo
The complexity of targeting EGFR signalling in cancer: from expression to turnover.
Biochimica et biophysica acta 2006;1766(1):120-39.
2006: Sharma Sreenath V; Fischbach Michael A; Haber Daniel A; Settleman Jeffrey
"Oncogenic shock": explaining oncogene addiction through differential signal attenuation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4392s-4395s.
2006: Lynch Thomas J; Adjei Alex A; Bunn Paul A; Eisen Tim G; Engelman Jeffrey; Goss Glenwood D; Haber Daniel A; Heymach John V; Jänne Pasi A; Johnson Bruce E; Johnson David H; Lilenbaum Rogerio C; Meyerson Matthew; Sandler Alan B; Sequist Lecia V; Settleman Jeffrey; Wong Kwok-Kin; Hart Carol S
Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4365s-4371s.
2006: Kwak Eunice L; Jankowski Janusz; Thayer Sarah P; Lauwers Gregory Y; Brannigan Brian W; Harris Patricia L; Okimoto Ross A; Haserlat Sara M; Driscoll David R; Ferry David; Muir Beth; Settleman Jeff; Fuchs Charles S; Kulke Matthew H; Ryan David P; Clark Jeff W; Sgroi Dennis C; Haber Daniel A; Bell Daphne W
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4283-7.
2006: Smolen Gromoslaw A; Sordella Raffaella; Muir Beth; Mohapatra Gayatry; Barmettler Anne; Archibald Heidi; Kim Woo J; Okimoto Ross A; Bell Daphne W; Sgroi Dennis C; Christensen James G; Settleman Jeffrey; Haber Daniel A
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2316-21.
2006: Matheson Stephen F; Hu Kang-Quan; Brouns Madeleine R; Sordella Raffaella; VanderHeide John D; Settleman Jeffrey
Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development.
Developmental neuroscience 2006;28(6):538-50.
2006: Verdier Valerie; Guang-Chao-Chen; Settleman Jeffrey
Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development.
BMC developmental biology 2006;6():38.
2006: Fischbach Michael A; Settleman Jeffrey
Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase.
Methods in enzymology 2006;407():33-45.
2006: Ligeti Erzsébet; Settleman Jeffrey
Regulation of RhoGAP specificity by phospholipids and prenylation.
Methods in enzymology 2006;406():104-17.
2005: Bell Daphne W; Gore Ira; Okimoto Ross A; Godin-Heymann Nadia; Sordella Raffaella; Mulloy Roseann; Sharma Sreenath V; Brannigan Brian W; Mohapatra Gayatry; Settleman Jeff; Haber Daniel A
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
Nature genetics 2005;37(12):1315-6.
2005: Barberis Davide; Casazza Andrea; Sordella Raffaella; Corso Simona; Artigiani Stefania; Settleman Jeff; Comoglio Paolo M; Tamagnone Luca
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Journal of cell science 2005;118(Pt 20):4689-700.
2005: Haber Daniel A; Settleman Jeffrey
Overcoming acquired resistance to Iressa/Tarceva with inhibitors of a different class.
Cell cycle (Georgetown, Tex.) 2005;4(8):1057-9.
2005: Bernards Andre; Settleman Jeffrey
GAPs in growth factor signalling.
Growth factors (Chur, Switzerland) 2005;23(2):143-9.
2005: Kwak Eunice L; Sordella Raffaella; Bell Daphne W; Godin-Heymann Nadia; Okimoto Ross A; Brannigan Brian W; Harris Patricia L; Driscoll David R; Fidias Panos; Lynch Thomas J; Rabindran Sridhar K; McGinnis John P; Wissner Allan; Sharma Sreenath V; Isselbacher Kurt J; Settleman Jeffrey; Haber Daniel A
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7665-70.
2005: Settleman Jeffrey
Intercalating Arabidopsis leaf cells: a jigsaw puzzle of lobes, necks, ROPs, and RICs.
Cell 2005;120(5):570-2.
2005: Chen Guang-Chao; Turano Brian; Ruest Paul J; Hagel Margit; Settleman Jeffrey; Thomas Sheila M
Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.
Molecular and cellular biology 2005;25(3):979-87.
2005: Jiang Wei; Sordella Raffaella; Chen Guang-Chao; Hakre Shweta; Roy Ananda L; Settleman Jeffrey
An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression.
Molecular cell 2005;17(1):23-35.
2005: Haber D A; Bell D W; Sordella R; Kwak E L; Godin-Heymann N; Sharma S V; Lynch T J; Settleman J
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():419-26.
2004: Settleman Jeffrey
Inhibition of mutant EGF receptors by gefitinib: targeting an Achilles' heel of lung cancer.
Cell cycle (Georgetown, Tex.) 2004;3(12):1496-7.
2004: Song Young-Han; Mirey Gladys; Betson Martha; Haber Daniel A; Settleman Jeffrey
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
Current biology : CB 2004;14(15):1354-9.
2004: Sordella Raffaella; Bell Daphne W; Haber Daniel A; Settleman Jeffrey
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.
Science (New York, N.Y.) 2004;305(5687):1163-7.
2004: Bernards Andre; Settleman Jeffrey
GAP control: regulating the regulators of small GTPases.
Trends in cell biology 2004;14(7):377-85.
2004: Kontaridis Maria I; Eminaga Seda; Fornaro Mara; Zito Christina Ivins; Sordella Raffaella; Settleman Jeffrey; Bennett Anton M
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.
Molecular and cellular biology 2004;24(12):5340-52.
2004: Lynch Thomas J; Bell Daphne W; Sordella Raffaella; Gurubhagavatula Sarada; Okimoto Ross A; Brannigan Brian W; Harris Patricia L; Haserlat Sara M; Supko Jeffrey G; Haluska Frank G; Louis David N; Christiani David C; Settleman Jeff; Haber Daniel A
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
The New England journal of medicine 2004;350(21):2129-39.
2004: Barker Thomas H; Grenett Hernan E; MacEwen Mark W; Tilden Samuel G; Fuller Gerald M; Settleman Jeffrey; Woods Anne; Murphy-Ullrich Joanne; Hagood James S
Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity.
Experimental cell research 2004;295(2):488-96.
2004: Settleman Jeffrey
Tension precedes commitment-even for a stem cell.
Molecular cell 2004;14(2):148-50.
2004: Hernández Samuel E; Settleman Jeffrey; Koleske Anthony J
Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase.
Current biology : CB 2004;14(8):691-6.
2004: Chen Guang-Chao; Gajowniczek Patrycja; Settleman Jeffrey
Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis.
Current biology : CB 2004;14(4):309-13.
2004: Ligeti Erzsébet; Dagher Marie-Claire; Hernandez Samuel E; Koleske Anthony J; Settleman Jeffrey
Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein.
The Journal of biological chemistry 2004;279(7):5055-8.
2003: Fischbach Michael A; Settleman Jeffrey
Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase.
Cancer research 2003;63(14):4089-94.
2003: Wennerberg Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.
Current biology : CB 2003;13(13):1106-15.
2003: Settleman Jeffrey
A memory GAP.
Trends in neurosciences 2003;26(6):285-7.
2003: Chakravarty Geetika; Hadsell Darryl; Buitrago William; Settleman Jeffrey; Rosen Jeffrey M
p190-B RhoGAP regulates mammary ductal morphogenesis.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1054-65.
2003: Settleman Jeffrey
A nuclear MAL-function links Rho to SRF.
Molecular cell 2003;11(5):1121-3.
2003: Sordella Raffaella; Jiang Wei; Chen Guang-Chao; Curto Marcello; Settleman Jeffrey
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis.
Cell 2003;113(2):147-58.
2003: Yajnik Vijay; Paulding Charles; Sordella Raffaella; McClatchey Andrea I; Saito Mako; Wahrer Doke C R; Reynolds Paul; Bell Daphne W; Lake Robert; van den Heuvel Sander; Settleman Jeff; Haber Daniel A
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Cell 2003;112(5):673-84.
2002: Sordella Raffaella; Classon Marie; Hu Kang Quan; Matheson Stephen F; Brouns Madeleine R; Fine Barry; Zhang Le; Takami Hiroya; Yamada Yoshihiko; Settleman Jeffrey
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Developmental cell 2002;2(5):553-65.
2001: Molnár G; Dagher M C; Geiszt M; Settleman J; Ligeti E
Role of prenylation in the interaction of Rho-family small GTPases with GTPase activating proteins.
Biochemistry 2001;40(35):10542-9.
2001: Brouns M R; Matheson S F; Settleman J
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.
Nature cell biology 2001;3(4):361-7.
2000: Brouns M R; Matheson S F; Hu K Q; Delalle I; Caviness V S; Silver J; Bronson R T; Settleman J
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.
Development (Cambridge, England) 2000;127(22):4891-903.
1999: Vincent S; Settleman J
Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization.
European journal of cell biology 1999;78(8):539-48.
1999: Lu Y; Settleman J
The role of rho family GTPases in development: lessons from Drosophila melanogaster.
Molecular cell biology research communications : MCBRC 1999;1(2):87-94.
1999: Lu Y; Settleman J
The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis.
Genes & development 1999;13(9):1168-80.
1999: Settleman J
Rho GTPases in development.
Progress in molecular and subcellular biology 1999;22():201-29.
1998: Nolan K M; Barrett K; Lu Y; Hu K Q; Vincent S; Settleman J
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.
Genes & development 1998;12(21):3337-42.
1998: Wang Y; Falasca M; Schlessinger J; Malstrom S; Tsichlis P; Settleman J; Hu W; Lim B; Prywes R
Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):513-22.
1998: Maheswaran S; Englert C; Lee S B; Ezzel R M; Settleman J; Haber D A
E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.
Oncogene 1998;16(16):2041-50.
1998: Vincent S; Brouns M; Hart M J; Settleman J
Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2210-5.
1997: Barrett K; Leptin M; Settleman J
The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation.
Cell 1997;91(7):905-15.
1997: Vincent S; Settleman J
The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.
Molecular and cellular biology 1997;17(4):2247-56.
1997: Hu K Q; Settleman J
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation.
The EMBO journal 1997;16(3):473-83.
1996: Foster R; Hu K Q; Lu Y; Nolan K M; Thissen J; Settleman J
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.
Molecular and cellular biology 1996;16(6):2689-99.
1995: Hariharan I K; Hu K Q; Asha H; Quintanilla A; Ezzell R M; Settleman J
Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.
The EMBO journal 1995;14(2):292-302.
1995: Settleman J; Foster R
Purification and GTPase-activating protein activity of baculovirus expressed p190.
Methods in enzymology 1995;256():105-13.
1994: Foster R; Hu K Q; Shaywitz D A; Settleman J
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.
Molecular and cellular biology 1994;14(11):7173-81.

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