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Jeffrey Settleman

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Ryan B Corcoran; Dora Dias-Santagata; Hiromichi Ebi; Cyril H Benes; Ronald D Brown; Katherine A Cheng; Erin M Coffee; Travis J Cohoon; Anthony C Faber; Jason T Godfrey; Patricia Greninger; Aaron N Hata; Kenneth E Hung; Eugene Lifshits; Mari Mino-Kenudson; Jeffrey Settleman; Toshi Shioda; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.
Csilla Hegedüs; György Kéri; Katalin Német; László Őrfi; Csilla Ozvegy-Laczka; Jeffrey Settleman; Gergely Szakács; Krisztina Truta-Feles; András Váradi; György Várady; Géza Antalffy; Balázs Sarkadi
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.
Kristy J Wilson; Timothy R Wilson; Jeffrey Settleman; Laura M C Ades; Jennifer Buchman; Richard M Gallo; Victor Hernandez-Gordillo; Sydney Lambert; Christopher Mill; David J Riese
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.

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All Publications

2013: Ryan B Corcoran; Dora Dias-Santagata; Hiromichi Ebi; Cyril H Benes; Ronald D Brown; Katherine A Cheng; Erin M Coffee; Travis J Cohoon; Anthony C Faber; Jason T Godfrey; Patricia Greninger; Aaron N Hata; Kenneth E Hung; Eugene Lifshits; Mari Mino-Kenudson; Jeffrey Settleman; Toshi Shioda; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.
Cancer cell 2013;23(1):121-8.
2012: Csilla Hegedüs; György Kéri; Katalin Német; László Őrfi; Csilla Ozvegy-Laczka; Jeffrey Settleman; Gergely Szakács; Krisztina Truta-Feles; András Váradi; György Várady; Géza Antalffy; Balázs Sarkadi
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.
Biochemical pharmacology 2012;84(3):260-7.
2012: Kristy J Wilson; Timothy R Wilson; Jeffrey Settleman; Laura M C Ades; Jennifer Buchman; Richard M Gallo; Victor Hernandez-Gordillo; Sydney Lambert; Christopher Mill; David J Riese
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.
Growth factors (Chur, Switzerland) 2012;30(2):107-16.
2012: Kristy J Wilson; Jeffrey Settleman; Henry VanBrocklin; Elizabeth Cameron; Richard M Gallo; Christopher P Mill; David J Riese
The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.
The Biochemical journal 2012;443(1):133-44.
2012: Ryan B Corcoran; Dora Dias-Santagata; Hiromichi Ebi; Ronald D Brown; Erin M Coffee; Alexandria P Cogdill; Keith T Flaherty; Kenneth E Hung; Mari Mino-Kenudson; Michiya Nishino; Adriano Piris; Jeffrey Settleman; Alexa B Turke; Jennifer A Wargo; Patricia Della Pelle; Jeffrey A Engelman
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
Cancer discovery 2012;2(3):227-35.
2012: Valentina Nardi; David P Ryan; Juan A Santamaria-Barria; Vanessa L Scialabba; Jeffrey Settleman; Youngchul Song; Hensin Tsao; Beow Y Yeap; Kristin Bergethon; Atul K Bhan; Genevieve M Boland; Darrell R Borger; Arjola K Cosper; James C Cusack; Jeffrey A Engelman; Anthony C Faber; Mai P Hoang; A John Iafrate; Quynh Lam; Dora Dias-Santagata
Activation of PI3K signaling in Merkel cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1227-36.
2012: Jeffrey Settleman
Oncogene addiction.
Current biology : CB 2012;22(2):R43-4.
2012: Yuting Sun; Bu-Er Wang; Peng Yue; Darrell Chen; Wei-Qiang Gao; Suchit Jhunjhunwala; Kevin G Leong; Li Li; Zora Modrusan; Kyounghee Seo; Jeffrey Settleman; Leisa Johnson
Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy.
Cancer research 2012;72(2):527-36.
2011: B M Heckman-Stoddard; M P Herrick; Michael Lewis; Jeffrey Settleman; Tracy Vargo-Gogola; A P Visbal; Jeffrey M Rosen
P190A RhoGAP is required for mammary gland development.
Developmental biology 2011;360(1):1-10.
2011: Hiromichi Ebi; Cyril Benes; Lewis C Cantley; Zhao Chen; Ryan B Corcoran; Eugene Lifshits; Jeffrey A Meyerhardt; David P Ryan; Jeffrey Settleman; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
The Journal of clinical investigation 2011;121(11):4311-21.
2011: Meng Wang; Michael Baumann; Cyril Benes; Jochen Dahm-Daphi; Ekkehard Dikomey; Liliana Gheorghiu; Mechthild Krause; Malte Kriegs; Fabian Morsbach; Akash Nanda; David Sander; Jeffrey Settleman; Henning Willers
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.
Cancer research 2011;71(19):6261-9.
2011: Christopher P Mill; S Michael Rothenberg; Jeffrey Settleman; Michael D Zordan; James F Leary; David J Riese
ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer.
Genes & cancer 2011;2(8):792-804.
2011: Ryan B Corcoran; Vikram Deshpande; Jeffrey A Engelman; David E Levy; Jeffrey Settleman; Alexandros Tzatsos; Cyril H Benes; Claudius Conrad; Gianmarco Contino; Nabeel Bardeesy
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.
Cancer research 2011;71(14):5020-9.
2011: Erik A Nelson; Jeffrey Settleman; Sreenath V Sharma; David A Frank
A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation.
Oncotarget 2011;2(6):518-24.
2011: Katrin Tschöp; Andrew R Conery; Larisa Litovchick; James A DeCaprio; Jeffrey Settleman; Ed Harlow; Nicholas J Dyson
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Genes & development 2011;25(8):814-30.
2011: Ryan B Corcoran; Jeffrey Settleman; Jeffrey A Engelman
Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers.
Oncotarget 2011;2(4):336-46.
2011: Hiroyuki Inuzuka; Shavali Shaik; Ichiro Onoyama; Daming Gao; Alan Tseng; richard s maser; Bo Zhai; Lixin Wan; Alejandro Gutierrez; Alan W Lau; Yonghong Xiao; Amanda L Christie; Jon Aster; Jeffrey Settleman; Steven P Gygi; Andrew L Kung; Thomas Look; Keiichi I Nakayama; Ronald A DePinho; Wenyi Wei
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Nature 2011;471(7336):104-9.
2010: Tamás Németh; Krisztina Futosi; Csilla Hably; Madeleine R Brouns; Sascha M Jakob; Miklós Kovács; Zsuzsanna Kertész; Barbara Walzog; Jeffrey Settleman; Attila Mócsai
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):3064-75.
2010: Chan-Young Jeon; Hee-Jun Kim; Hiroshi Morii; Nozomu Mori; Jeffrey Settleman; Jae-Yong Lee; Jaebong Kim; Sung-Chan Kim; Jae-Bong Park
Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3.
Journal of cellular physiology 2010;224(3):786-94.
2010: anurag singh; Jeffrey Settleman
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer.
Oncogene 2010;29(34):4741-51.
2010: Dora Dias-Santagata; Sara Akhavanfard; Serena S David; Kathy Vernovsky; Georgiana Kuhlmann; Susan L Boisvert; Hannah Stubbs; Ultan McDermott; Jeffrey Settleman; Eunice L Kwak; Jeffrey W Clark; Steven J Isakoff; Lecia V Sequist; Jeffrey A Engelman; Thomas J Lynch; Daniel A Haber; David N Louis; Leif W Ellisen; Darrell R Borger; A John Iafrate
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.
EMBO molecular medicine 2010;2(5):146-58.
2010: Sreenath V Sharma; Diana Y Lee; Bihua Li; Margaret P Quinlan; Fumiyuki Takahashi; Shyamala Maheswaran; Ultan McDermott; Nancy Azizian; Lee Zou; Michael A Fischbach; Kwok-Kin Wong; Kathleyn Brandstetter; Ben Wittner; Sridhar Ramaswamy; Marie Classon; Jeffrey Settleman
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Cell 2010;141(1):69-80.
2010: Wenjun Zhou; Wooyoung Hur; Ultan McDermott; Amit Dutt; Wa Xian; Scott B Ficarro; Jianming Zhang; Sreenath V Sharma; Joan Brugge; Matthew Meyerson; Jeffrey Settleman; Nathanael S Gray
A structure-guided approach to creating covalent FGFR inhibitors.
Chemistry & biology 2010;17(3):285-95.
2010: S Michael Rothenberg; Gayatry Mohapatra; Miguel N Rivera; Daniel Winokur; Patricia Greninger; Mai Nitta; Peter M Sadow; Gaya Sooriyakumar; Brian W Brannigan; Matthew J Ulman; Rushika M Perera; Rui Wang; Angela Tam; Xiao-Jun Ma; Mark Erlander; Dennis C Sgroi; James William Rocco; Mark W Lingen; Ezra E W Cohen; David N Louis; Jeffrey Settleman; Daniel A Haber
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer research 2010;70(6):2158-64.
2010: Ultan McDermott; Raju V Pusapati; James G Christensen; Nathanael S Gray; Jeffrey Settleman
Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency.
Cancer research 2010;70(4):1625-34.
2010: Ryan B Corcoran; Dora Dias-Santagata; Kristin Bergethon; A John Iafrate; Jeffrey Settleman; Jeffrey A Engelman
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.
Science signaling 2010;3(149):ra84.
2009: Ultan McDermott; Jeffrey Settleman
Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(33):5650-9.
2009: Haiming Xu; Satyam Eleswarapu; Hartmut Geiger; Kathleen Szczur; Deidre Daria; Yi Zheng; Jeffrey Settleman; Edward F Srour; David A Williams; Marie-Dominique Filippi
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood 2009;114(17):3557-66.
2009: Jeffrey Settleman
A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.
Cancer cell 2009;16(4):278-9.
2009: Magdolna Lévay; Jeffrey Settleman; Erzsébet Ligeti
Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.
Biochemistry 2009;48(36):8615-23.
2009: Alice T Shaw; Beow Y Yeap; Mari Mino-Kenudson; Subba R Digumarthy; Daniel B Costa; C. Rebecca Suk Heist; Benjamin Solomon; Hannah Stubbs; Sonal Admane; Ultan McDermott; Jeffrey Settleman; Susumu Kobayashi; Eugene J Mark; Scott J Rodig; Lucian R Chirieac; Eunice L Kwak; Thomas J Lynch; A John Iafrate
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(26):4247-53.
2009: Ultan McDermott; Rachel Y Ames; A John Iafrate; Shyamala Maheswaran; Hannah Stubbs; Patricia Greninger; Kaitlin McCutcheon; Randy Milano; Angela Tam; Diana Y Lee; Laury Lucien; Brian W Brannigan; Lindsey Ulkus; Xiao-Jun Ma; Mark G Erlander; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.
Cancer research 2009;69(9):3937-46.
2009: Ruben Plentz; Ji-Sun Park; Andrew D Rhim; Daniel Abravanel; Aram F Hezel; Sreenath V Sharma; Sushma Gurumurthy; Vikram Deshpande; Candia Kenific; Jeffrey Settleman; Pradip K Majumder; Ben Z Stanger; Nabeel Bardeesy
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.
Gastroenterology 2009;136(5):1741-9.e6.
2009: Sreenath V Sharma; Jeffrey Settleman
ErbBs in lung cancer.
Experimental cell research 2009;315(4):557-71.
2009: Margaret P Quinlan; Jeffrey Settleman
Isoform-specific ras functions in development and cancer.
Future oncology (London, England) 2009;5(1):105-16.
2009: Brandy M Heckman-Stoddard; Tracy Vargo-Gogola; Peter R McHenry; Vivian Jiang; Matthew P Herrick; Susan G Hilsenbeck; Jeffrey Settleman; Jeffrey M Rosen
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
Breast cancer research : BCR 2009;11(4):R61.
2009: André Bernards; Jeffrey Settleman
Loss of the Ras regulator RASAL1: another route to Ras activation in colorectal cancer.
Gastroenterology 2009;136(1):46-8.
2008: Tan Min Chin; Margaret P Quinlan; Anurag Singh; Lecia V Sequist; Thomas J Lynch; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Reduced Erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6867-76.
2008: Che-Hung Shen; Hsin-Yi Chen; Ming-Shien Lin; Fang-Yen Li; Cheng-Chi Chang; Min-Liang Kuo; Jeffrey Settleman; Ruey-Hwa Chen
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.
Cancer research 2008;68(19):7779-87.
2008: S Michael Rothenberg; Jeffrey A Engelman; Sheila Le; David J Riese; Daniel A Haber; Jeffrey Settleman
Modeling oncogene addiction using RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12480-4.
2008: Wei Jiang; Martha Betson; Roseann Mulloy; Rosemary Foster; Magdolna Lévay; Erzsébet Ligeti; Jeffrey Settleman
p190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration.
The Journal of biological chemistry 2008;283(30):20978-88.
2008: Shyamala Maheswaran; Lecia V Sequist; Sunitha Nagrath; Lindsey Ulkus; Brian Brannigan; Chey V Collura; Elizabeth Inserra; Sven Diederichs; A John Iafrate; Daphne W Bell; Subba R Digumarthy; Alona Muzikansky; daniel irimia; Jeffrey Settleman; Ronald G Tompkins; Thomas J Lynch; Mehmet Toner; Daniel A Haber
Detection of mutations in EGFR in circulating lung-cancer cells.
The New England journal of medicine 2008;359(4):366-77.
2008: Margaret P Quinlan; Jeffrey Settleman
[A Kras-specific function in cancer initiation].
Ai zheng = Aizheng = Chinese journal of cancer 2008;27(7):673-4.
2008: Daphne W Bell; Brian W Brannigan; Keitaro Matsuo; Dianne M Finkelstein; Raffaella Sordella; Jeffrey Settleman; Tetsuya Mitsudomi; Daniel A Haber
Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4079-84.
2008: Mark D Bass; Mark R Morgan; Kirsty A Roach; Jeffrey Settleman; Andrew B Goryachev; Martin J Humphries
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.
The Journal of cell biology 2008;181(6):1013-26.
2008: Clara Montagut; Sreenath V Sharma; Toshi Shioda; Ultan McDermott; Matthew Ulman; Lindsey Ulkus; Dora Dias-Santagata; Hannah Stubbs; Diana Y Lee; Anurag Singh; Lisa Drew; Daniel A Haber; Jeffrey Settleman
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.
Cancer research 2008;68(12):4853-61.
2008: Buzz Baum; Jeffrey Settleman; Margaret P Quinlan
Transitions between epithelial and mesenchymal states in development and disease.
Seminars in cell & developmental biology 2008;19(3):294-308.
2008: Jeffrey Settleman; Buzz Baum
Cell shape and tissue morphogenesis.
Seminars in cell & developmental biology 2008;19(3):213-4.
2008: Pankaj Gupta; Luni Emdad; Irina Lebedeva; Devanand Sarkar; Paul Dent; David T Curiel; Jeffrey Settleman; Paul B Fisher
Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.
Journal of cellular physiology 2008;215(3):827-36.
2008: Lecia V Sequist; Renato G Martins; David Spigel; Steven M Grunberg; Alexander Spira; Pasi A Janne; Victoria A Joshi; David McCollum; Tracey L Evans; Alona Muzikansky; Georgiana L Kuhlmann; Moon Han; Jonathan S Goldberg; Jeffrey Settleman; A John Iafrate; Jeffrey A Engelman; Daniel A Haber; Bruce E Johnson; Thomas J Lynch
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(15):2442-9.
2008: Margaret P Quinlan; Jeffrey Settleman
Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.
Cell cycle (Georgetown, Tex.) 2008;7(10):1332-5.
2008: Ultan McDermott; A John Iafrate; Nathanael S Gray; Toshi Shioda; Marie Classon; Shyamala Maheswaran; Wenjun Zhou; Hwan Geun Choi; Shannon L Smith; Lori Dowell; Lindsey Ulkus; Georgiana Kuhlmann; Patricia Greninger; James G Christensen; Daniel A Haber; Jeffrey Settleman
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research 2008;68(9):3389-95.
2008: Kevin Haigis; Krystle R Kendall; Yufang Wang; Ann Cheung; Marcia C Haigis; Jonathan N Glickman; Michiko Niwa-Kawakita; Eric A. Sweet-Cordero; Judith Leopold; Kevin Shannon; Jeffrey Settleman; Marco Giovannini; Tyler Jacks
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Nature genetics 2008;40(5):600-8.
2008: Nadia Godin-Heymann; Lindsey Ulkus; Brian W Brannigan; Ultan McDermott; Jennifer Lamb; Shyamala Maheswaran; Jeffrey Settleman; Daniel A Haber
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.
Molecular cancer therapeutics 2008;7(4):874-9.
2008: Margaret P Quinlan; Steven E Quatela; Mark R Philips; Jeffrey Settleman
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.
Molecular and cellular biology 2008;28(8):2659-74.
2008: Jeffrey A Engelman; Jeffrey Settleman
Acquired resistance to tyrosine kinase inhibitors during cancer therapy.
Current opinion in genetics & development 2008;18(1):73-9.
2008: Ultan McDermott; Sreenath V Sharma; Jeffrey Settleman
High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.
Methods in enzymology 2008;438():331-41.
2008: Guang-Chao Chen; Janice Y. Lee; Hong-Wen Tang; Jayanta Debnath; Sheila M Thomas; Jeffrey Settleman
Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.
Autophagy 2008;4(1):37-45.
2007: Sreenath V Sharma; Jeffrey Settleman
Oncogene addiction: setting the stage for molecularly targeted cancer therapy.
Genes & development 2007;21(24):3214-31.
2007: Ultan McDermott; Sreenath V Sharma; Lori Dowell; Patricia Greninger; Clara Montagut; Jennifer Lamb; Heidi Archibald; Raul Raudales; Angela Tam; Diana Lee; S Michael Rothenberg; Jeffrey G Supko; Raffaella Sordella; Lindsey Ulkus; A John Iafrate; Shyamala Maheswaran; Ching-Ni Njauw; Hensin Tsao; Lisa Drew; Jeff H Hanke; Xiao-Jun Ma; Mark G Erlander; Nathanael S Gray; Daniel A Haber; Jeffrey Settleman
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19936-41.
2007: Mindan K Sfakianos; Aaron Eisman; Shannon L Gourley; William D Bradley; Alfred Scheetz; Jeffrey Settleman; Jane R Taylor; Charles A Greer; Anne Williamson; Anthony J Koleske
Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10982-92.
2007: Andre Bernards; Jeffrey Settleman
GEFs in growth factor signaling.
Growth factors (Chur, Switzerland) 2007;25(5):355-61.
2007: Brandy M Heckman; Geetika Chakravarty; Tracy Vargo-Gogola; Maria Gonzales-Rimbau; Darryl L Hadsell; Adrian V Lee; Jeffrey Settleman; Jeffrey M Rosen
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Developmental biology 2007;309(1):137-49.
2007: Nadia Godin-Heymann; Ianthe Bryant; Miguel N Rivera; Lindsey Ulkus; Daphne W Bell; David J Riese; Jeffrey Settleman; Daniel A Haber
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.
Cancer research 2007;67(15):7319-26.
2007: Martha Betson; Jeffrey Settleman
A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.
Genetics 2007;176(4):2201-12.
2007: Jeffrey Settleman; Jonathan M Kurie
Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.
Cancer cell 2007;12(1):6-8.
2007: David J Riese; Richard M Gallo; Jeffrey Settleman
Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(6):558-65.
2007: Daniel A Haber; Jeffrey Settleman
Cancer: drivers and passengers.
Nature 2007;446(7132):145-6.
2007: Roseann Mulloy; Audrey Ferrand; Youngjoo Kim; Raffaella Sordella; Daphne W Bell; Daniel A Haber; Karen S Anderson; Jeffrey Settleman
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.
Cancer research 2007;67(5):2325-30.
2007: Sreenath V Sharma; Daphne W Bell; Jeffrey Settleman; Daniel A Haber
Epidermal growth factor receptor mutations in lung cancer.
Nature reviews. Cancer 2007;7(3):169-81.
2007: Luni Emdad; Irina Lebedeva; Zao-Zhong Su; Pankaj Gupta; Devanand Sarkar; Jeffrey Settleman; Paul B Fisher
Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.
Journal of cellular physiology 2007;210(2):549-59.
2007: Jeffrey Settleman
PAK-in' up cGMP for the move.
Cell 2007;128(2):237-8.
2006: Sreenath V Sharma; Jeffrey Settleman
Oncogenic shock: turning an activated kinase against the tumor cell.
Cell cycle (Georgetown, Tex.) 2006;5(24):2878-80.
2006: Gregg A Wildenberg; Michael R. Dohn; Robert H Carnahan; Michael A Davis; Nichole A Lobdell; Jeffrey Settleman; Albert B Reynolds
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
Cell 2006;127(5):1027-39.
2006: Sreenath V Sharma; Patrycja Gajowniczek; Inna P Way; Diana Y Lee; Jane Jiang; Yuki Yuza; Marie Classon; Daniel A Haber; Jeffrey Settleman
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
Cancer cell 2006;10(5):425-35.
2006: William D Bradley; Samuel E Hernández; Jeffrey Settleman; Anthony J Koleske
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Molecular biology of the cell 2006;17(11):4827-36.
2006: Shweta Hakre; Maria Isabel Tussie-Luna; Todd Ashworth; Carl D Novina; Jeffrey Settleman; Phillip A Sharp; Ananda L Roy
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
Molecular cell 2006;24(2):301-8.
2006: Valerie Verdier; James E Johndrow; Martha Betson; Guang-Chao Chen; David A Hughes; Susan M Parkhurst; Jeffrey Settleman
Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.
Developmental biology 2006;297(2):417-32.
2006: Sinto Sebastian; Jeffrey Settleman; Stephan J Reshkin; Amalia Azzariti; Antonia Bellizzi; angelo paradiso
The complexity of targeting EGFR signalling in cancer: from expression to turnover.
Biochimica et biophysica acta 2006;1766(1):120-39.
2006: Sreenath V Sharma; Michael A Fischbach; Daniel A Haber; Jeffrey Settleman
"Oncogenic shock": explaining oncogene addiction through differential signal attenuation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4392s-4395s.
2006: Thomas J Lynch; Alex A. Adjei; Paul A Bunn; Tim G Eisen; Jeffrey A Engelman; Glenwood Goss; Daniel A Haber; John V Heymach; Pasi A Janne; Bruce E Johnson; David H Johnson; Rogerio Lilenbaum; Matthew Meyerson; Alan B Sandler; Lecia V Sequist; Jeffrey Settleman; Kwok-Kin Wong; Carol S Hart
Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4365s-4371s.
2006: Eunice L Kwak; Janusz Jankowski; Sarah P Thayer; Gregory Y Lauwers; Brian W Brannigan; Patricia Neal; Ross A Okimoto; Sara M Haserlat; David R Driscoll; David Ferry; Beth Muir; Jeffrey Settleman; Charlie S Fuchs; Matthew H Kulke; David P Ryan; jeffrey clark; Dennis C Sgroi; Daniel A Haber; Daphne W Bell
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4283-7.
2006: Gromoslaw A Smolen; Raffaella Sordella; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Heidi Archibald; Woo J Kim; Ross A Okimoto; Daphne W Bell; Dennis C Sgroi; James G Christensen; Jeffrey Settleman; Daniel A Haber
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2316-21.
2006: Stephen F Matheson; Kang-Quan Hu; Madeleine R Brouns; Raffaella Sordella; John D VanderHeide; Jeffrey Settleman
Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development.
Developmental neuroscience 2006;28(6):538-50.
2006: Valerie Verdier; Jeffrey Settleman
Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development.
BMC developmental biology 2006;6():38.
2006: Michael A Fischbach; Jeffrey Settleman
Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase.
Methods in enzymology 2006;407():33-45.
2006: Erzsébet Ligeti; Jeffrey Settleman
Regulation of RhoGAP specificity by phospholipids and prenylation.
Methods in enzymology 2006;406():104-17.
2005: Daphne W Bell; Ira Gore; Ross A Okimoto; Nadia Godin-Heymann; Raffaella Sordella; Roseann Mulloy; Sreenath V Sharma; Brian W Brannigan; Gayatry Mohapatra; Jeffrey Settleman; Daniel A Haber
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
Nature genetics 2005;37(12):1315-6.
2005: Davide Barberis; Andrea Casazza; Raffaella Sordella; Simona Corso; Stefania Artigiani; Jeffrey Settleman; paolo comoglio; Luca Tamagnone
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Journal of cell science 2005;118(Pt 20):4689-700.
2005: Daniel A Haber; Jeffrey Settleman
Overcoming acquired resistance to Iressa/Tarceva with inhibitors of a different class.
Cell cycle (Georgetown, Tex.) 2005;4(8):1057-9.
2005: Andre Bernards; Jeffrey Settleman
GAPs in growth factor signalling.
Growth factors (Chur, Switzerland) 2005;23(2):143-9.
2005: Eunice L Kwak; Raffaella Sordella; Daphne W Bell; Nadia Godin-Heymann; Ross A Okimoto; Brian W Brannigan; Patricia Neal; David R Driscoll; Panos Fidias; Thomas J Lynch; Sridhar K Rabindran; John P McGinnis; Allan Wissner; Sreenath V Sharma; Kurt J Isselbacher; Jeffrey Settleman; Daniel A Haber
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7665-70.
2005: Jeffrey Settleman
Intercalating Arabidopsis leaf cells: a jigsaw puzzle of lobes, necks, ROPs, and RICs.
Cell 2005;120(5):570-2.
2005: Guang-Chao Chen; Brian Turano; Paul J Ruest; Margit Hagel; Jeffrey Settleman; Sheila M Thomas
Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.
Molecular and cellular biology 2005;25(3):979-87.
2005: Wei Jiang; Raffaella Sordella; Guang-Chao Chen; Shweta Hakre; Ananda L Roy; Jeffrey Settleman
An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression.
Molecular cell 2005;17(1):23-35.
2005: Daniel A Haber; Daphne W Bell; Raffaella Sordella; Eunice L Kwak; Nadia Godin-Heymann; Sreenath V Sharma; Thomas J Lynch; Jeffrey Settleman
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():419-26.
2004: Jeffrey Settleman
Inhibition of mutant EGF receptors by gefitinib: targeting an Achilles' heel of lung cancer.
Cell cycle (Georgetown, Tex.) 2004;3(12):1496-7.
2004: Raffaella Sordella; Daphne W Bell; Daniel A Haber; Jeffrey Settleman
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.
Science (New York, N.Y.) 2004;305(5687):1163-7.
2004: Young-Han Song; Gladys Mirey; Martha Betson; Daniel A Haber; Jeffrey Settleman
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
Current biology : CB 2004;14(15):1354-9.
2004: Andre Bernards; Jeffrey Settleman
GAP control: regulating the regulators of small GTPases.
Trends in cell biology 2004;14(7):377-85.
2004: Maria I Kontaridis; Seda Eminaga; Mara Fornaro; Christina Ivins Zito; Raffaella Sordella; Jeffrey Settleman; Anton M Bennett
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.
Molecular and cellular biology 2004;24(12):5340-52.
2004: Thomas J Lynch; Daphne W Bell; Raffaella Sordella; Sarada Gurubhagavatula; Ross A Okimoto; Brian W Brannigan; Patricia Neal; Sara M Haserlat; Jeffrey G Supko; Frank G Haluska; David N Louis; David C Christiani; Jeffrey Settleman; Daniel A Haber
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
The New England journal of medicine 2004;350(21):2129-39.
2004: Thomas Barker; Hernan E Grenett; Mark W MacEwen; Samuel G Tilden; Gerald M Fuller; Jeffrey Settleman; Anne Woods; Joanne E Murphy-Ullrich; James Hagood
Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity.
Experimental cell research 2004;295(2):488-96.
2004: Jeffrey Settleman
Tension precedes commitment-even for a stem cell.
Molecular cell 2004;14(2):148-50.
2004: Samuel E Hernández; Jeffrey Settleman; Anthony J Koleske
Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase.
Current biology : CB 2004;14(8):691-6.
2004: Guang-Chao Chen; Patrycja Gajowniczek; Jeffrey Settleman
Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis.
Current biology : CB 2004;14(4):309-13.
2004: Erzsébet Ligeti; Marie-Claire Dagher; Samuel E Hernandez; Anthony J Koleske; Jeffrey Settleman
Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein.
The Journal of biological chemistry 2004;279(7):5055-8.
2003: Michael A Fischbach; Jeffrey Settleman
Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase.
Cancer research 2003;63(14):4089-94.
2003: Krister Wennerberg; Marie-Annick Forget; Shawn M Ellerbroek; William T Arthur; Keith Burridge; Jeffrey Settleman; Channing J Der; Steen H Hansen
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.
Current biology : CB 2003;13(13):1106-15.
2003: Jeffrey Settleman
A memory GAP.
Trends in neurosciences 2003;26(6):285-7.
2003: Geetika Chakravarty; Darryl L Hadsell; William Buitrago; Jeffrey Settleman; Jeffrey M Rosen
p190-B RhoGAP regulates mammary ductal morphogenesis.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1054-65.
2003: Jeffrey Settleman
A nuclear MAL-function links Rho to SRF.
Molecular cell 2003;11(5):1121-3.
2003: Raffaella Sordella; Wei Jiang; Guang-Chao Chen; Marcello Curto; Jeffrey Settleman
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis.
Cell 2003;113(2):147-58.
2003: Vijay Yajnik; Charles A Paulding; Raffaella Sordella; Andrea I McClatchey; Mako Saito; Doke C R Wahrer; Paul Reynolds; Daphne W Bell; Robert Lake; Sander van den Heuvel; Jeffrey Settleman; Daniel A Haber
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Cell 2003;112(5):673-84.
2002: Raffaella Sordella; Marie Classon; Kang-Quan Hu; Stephen F Matheson; Madeleine R Brouns; Barry Fine; Le Zhang; Hiroya Takami; Yoshihiko Yamada; Jeffrey Settleman
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Developmental cell 2002;2(5):553-65.
2001: Gergely Z Molnár; Marie-Claire Dagher; Miklós Geiszt; Jeffrey Settleman; Erzsébet Ligeti
Role of prenylation in the interaction of Rho-family small GTPases with GTPase activating proteins.
Biochemistry 2001;40(35):10542-9.
2001: Madeleine R Brouns; Stephen F Matheson; Jeffrey Settleman
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.
Nature cell biology 2001;3(4):361-7.
2000: Madeleine R Brouns; Stephen F Matheson; Kang-Quan Hu; Ivana Delalle; Verne S Caviness; J Silver; Roderick T Bronson; Jeffrey Settleman
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.
Development (Cambridge, England) 2000;127(22):4891-903.
1999: S Vincent; Jeffrey Settleman
Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization.
European journal of cell biology 1999;78(8):539-48.
1999: Y Lu; Jeffrey Settleman
The role of rho family GTPases in development: lessons from Drosophila melanogaster.
Molecular cell biology research communications : MCBRC 1999;1(2):87-94.
1999: Y Lu; Jeffrey Settleman
The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis.
Genes & development 1999;13(9):1168-80.
1999: Jeffrey Settleman
Rho GTPases in development.
Progress in molecular and subcellular biology 1999;22():201-29.
1998: K M Nolan; K Barrett; Y Lu; Kang-Quan Hu; S Vincent; Jeffrey Settleman
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.
Genes & development 1998;12(21):3337-42.
1998: Y Wang; M Falasca; J Schlessinger; SE Malstrom; Philip Tsichlis; Jeffrey Settleman; W Hu; B Lim; Ron Prywes
Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):513-22.
1998: Shyamala Maheswaran; C Englert; Sean B Lee; R M Ezzel; Jeffrey Settleman; Daniel A Haber
E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.
Oncogene 1998;16(16):2041-50.
1998: S Vincent; Madeleine R Brouns; Matthew J Hart; Jeffrey Settleman
Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2210-5.
1997: K Barrett; Maria Leptin; Jeffrey Settleman
The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation.
Cell 1997;91(7):905-15.
1997: S Vincent; Jeffrey Settleman
The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.
Molecular and cellular biology 1997;17(4):2247-56.
1997: Kang-Quan Hu; Jeffrey Settleman
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation.
The EMBO journal 1997;16(3):473-83.
1996: R Foster; Kang-Quan Hu; Y Lu; K M Nolan; J Thissen; Jeffrey Settleman
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.
Molecular and cellular biology 1996;16(6):2689-99.
1995: Iswar K Hariharan; Kang-Quan Hu; H Asha; A Quintanilla; Robert Ezzell; Jeffrey Settleman
Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.
The EMBO journal 1995;14(2):292-302.
1995: Jeffrey Settleman; R Foster
Purification and GTPase-activating protein activity of baculovirus expressed p190.
Methods in enzymology 1995;256():105-13.
1994: R Foster; Kang-Quan Hu; D A Shaywitz; Jeffrey Settleman
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.
Molecular and cellular biology 1994;14(11):7173-81.