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Andrew Sewell

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John Challier; Denis Bruniquel; Andrew K Sewell; Bruno Laugel
Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity.
Joanne L Welton; Salvador Martí; Matt P Morgan; Bernhard Moser; Andrew K Sewell; Michael D Stone; Jane Turton; Matthias Eberl
Monocytes and γδ T cells control the acute-phase response to intravenous zoledronate: insights from a phase IV safety trial.
Julia Ekeruche-Makinde; Sian Llewellyn-Lacey; John J Miles; Kim M Miles; Mark Peakman; Johanne M Pentier; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Andrea J A Schauenburg; Andrew K Sewell; Ania Skowera; Mai Ping Tan; Andrew Trimby; Hugo A van den Berg; Tamsin Williams; Mick Bailey; Anna M Bulek; Scott R Burrows; Mathew Clement; david cole; Garry Dolton; Linda Wooldridge
Peptide length determines the outcome of TCR/peptide-MHCI engagement.

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2013: John Challier; Denis Bruniquel; Andrew K Sewell; Bruno Laugel
Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity.
Immunology 2013;138(4):402-10.
2013: Joanne L Welton; Salvador Martí; Matt P Morgan; Bernhard Moser; Andrew K Sewell; Michael D Stone; Jane Turton; Matthias Eberl
Monocytes and γδ T cells control the acute-phase response to intravenous zoledronate: insights from a phase IV safety trial.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(3):464-71.
2013: Julia Ekeruche-Makinde; Sian Llewellyn-Lacey; John J Miles; Kim M Miles; Mark Peakman; Johanne M Pentier; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Andrea J A Schauenburg; Andrew K Sewell; Ania Skowera; Mai Ping Tan; Andrew Trimby; Hugo A van den Berg; Tamsin Williams; Mick Bailey; Anna M Bulek; Scott R Burrows; Mathew Clement; david cole; Garry Dolton; Linda Wooldridge
Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Blood 2013;121(7):1112-23.
2013: Weidong Xu; Margaret C Costanzo; Feng Jiao; Shinji Makino; John C Morrill; Clarence J Peters; Alessandro Sette; Andrew K Sewell; John Sidney; Xiaolei Tang; Leon A Venegas; Douglas M Watts; Linda Wooldridge; June Kan-Mitchell
The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses.
PloS one 2013;8(3):e59210.
2013: Robin R Knight; Deborah Kronenberg; Mark Peakman; Andrew K Sewell; Anna Bulek; david cole; Martin Eichmann; Guo Cai Huang; Linda Wooldridge; Min Zhao; Ania Skowera
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.
Diabetes 2013;62(1):205-13.
2012: Julia Ekeruche-Makinde; Anna Fuller; Emma Gostick; Kristin Ladell; Anna Lissina; Katy A Lloyd; Florian Madura; Katherine K Matthews; John J Miles; Johanne Pentier; David A Price; Pierre J Rizkallah; Brian M Baker; Tiffany K Baxter; Mathew Clement; david cole; Garry M Dolton; Emily S J Edwards; Linda Wooldridge; Andrew K Sewell
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
The Journal of biological chemistry 2012;287(44):37269-81.
2012: david cole; Bruno Laugel; David A Price; Mathew Clement; Linda Wooldridge; Andrew K Sewell
The molecular determinants of CD8 co-receptor function.
Immunology 2012;137(2):139-48.
2012: Andrew K Sewell
Why must T cells be cross-reactive?
Nature reviews. Immunology 2012;12(9):669-77.
2012: Anna M Bulek; david cole; Garry Dolton; Jan W Drijfhout; Anna Fuller; Emma Gostick; Stephanie Gras; Guo C Huang; Bent K Jakobsen; Robin R Knight; Nikolai M Lissin; Florian Madura; John J Miles; Peter E Molloy; Mark Peakman; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Ania Skowera; Linda Wooldridge; Andrew K Sewell
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nature immunology 2012;13(3):283-9.
2012: David K Cole; Kathleen Gallagher; Awen M Gallimore; Emma Gostick; Marie-Lise Gougeon; James P Hindley; Christopher J Holland; Sayed Junaid; Kristin Ladell; Brigitte Lemercier; David A Price; Andrew K Sewell; Katherine K Wynn; Andrew Godkin
Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection.
Nature communications 2012;3():665.
2011: Bruno Laugel; David A Price; Mathew Clement; david cole; Linda Wooldridge; Andrew K Sewell
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
Journal of leukocyte biology 2011;90(6):1089-99.
2011: Mathew Clement; david cole; Garry Dolton; Emily S J Edwards; Julia Ekeruche-Makinde; Awen Gallimore; Andrew Godkin; Kristin Ladell; Sarah Lauder; John J Miles; David A Price; Andrea J A Schauenburg; Andrew K Sewell; Tamsin Williams; Scott R Burrows; Linda Wooldridge
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):654-63.
2011: Kim M Miles; John J Miles; Florian Madura; Andrew K Sewell; david cole
Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.
Molecular immunology 2011;48(4):728-32.
2010: Linda Wooldridge; Bruno Laugel; Julia Ekeruche; Mathew Clement; Hugo A van den Berg; David A Price; Andrew K Sewell
CD8 controls T cell cross-reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(8):4625-32.
2010: david cole; Emily S J Edwards; Katherine K Wynn; Mathew Clement; John J Miles; Kristin Ladell; Julia Ekeruche; Emma Gostick; Katherine J Adams; Ania Skowera; Mark Peakman; Linda Wooldridge; David A Price; Andrew K Sewell
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2600-10.
2010: Keri L Schaubert; David A Price; Janelle R Salkowitz; Andrew K Sewell; John Sidney; Tedi E Asher; Sylvie E Blondelle; Sharon Adams; Francesco M Marincola; Aviva Joseph; Alessandro Sette; Daniel C Douek; Velpandi Ayyavoo; Walter Storkus; Ming-Ying Leung; Hwee L Ng; Otto O Yang; Harris Goldstein; Darcy B Wilson; June Kan-Mitchell
Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.
European journal of immunology 2010;40(7):1950-62.
2010: Linda Wooldridge; Mathew Clement; Anna Lissina; Emily S J Edwards; Kristin Ladell; Julia Ekeruche; Rachel E Hewitt; Bruno Laugel; Emma Gostick; david cole; Reno Debets; Cor Berrevoets; John J Miles; Scott R Burrows; David A Price; Andrew K Sewell
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3357-66.
2010: L J Walker; Andrew K Sewell; Paul Klenerman
T cell sensitivity and the outcome of viral infection.
Clinical and experimental immunology 2010;159(3):245-55.
2010: Ji-Li Chen; Anthony J Morgan; Guillaume Stewart-Jones; Dawn Shepherd; Giovanna Bossi; Linda Wooldridge; Sarah L Hutchinson; Andrew K Sewell; Gillian M Griffiths; Philip van der Merwe; E Yvonne Jones; Antony Galione; Vincenzo Cerundolo
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1829-39.
2010: John J Miles; Anna M Bulek; David K Cole; Emma Gostick; Andrea J A Schauenburg; Garry Dolton; Vanessa Venturi; Miles P Davenport; Mai Ping Tan; Scott R Burrows; Linda Wooldridge; David A Price; Pierre J Rizkallah; Andrew K Sewell
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
PLoS pathogens 2010;6(11):e1001198.
2009: Linda Wooldridge; Anna Lissina; david cole; Hugo A van den Berg; David A Price; Andrew K Sewell
Tricks with tetramers: how to get the most from multimeric peptide-MHC.
Immunology 2009;126(2):147-64.
2008: Pratip K Chattopadhyay; J Joseph Melenhorst; Kristin Ladell; Emma Gostick; Phillip Scheinberg; A John Barrett; Linda Wooldridge; Mario Roederer; Andrew K Sewell; David A Price
Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(11):1001-9.
2008: Thomas J Scriba; Sophie Sierro; Eric L Brown; Rodney E Phillips; Andrew K Sewell; Ruth C Massey
The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines.
Infection and immunity 2008;76(5):2164-8.
2008: david cole; Steven M Dunn; malkit sami; Jonathan M Boulter; Bent K Jakobsen; Andrew K Sewell
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.
Molecular immunology 2008;45(9):2700-9.
2007: Ruth C Massey; Thomas J Scriba; Eric L Brown; Rodney E Phillips; Andrew K Sewell
Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells.
Infection and immunity 2007;75(12):5711-5.
2007: Hugo A van den Berg; Linda Wooldridge; Bruno Laugel; Andrew K Sewell
Coreceptor CD8-driven modulation of T cell antigen receptor specificity.
Journal of theoretical biology 2007;249(2):395-408.
2007: Fang Yuan; Theonie Georgiou; Theresa Hillon; Emma Gostick; David A Price; Andrew K Sewell; Ruth Moysey; Jessie Gavarret; Annelise Vuidepot; malkit sami; John I Bell; George F Gao; Pierre J Rizkallah; Bent K Jakobsen
Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 9):758-60.
2007: Bruno Laugel; Hugo A van den Berg; Emma Gostick; david cole; Linda Wooldridge; Jonathan M Boulter; Anita Milicic; David A Price; Andrew K Sewell
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties.
The Journal of biological chemistry 2007;282(33):23799-810.
2007: Marco A Purbhoo; Yi Li; Deborah H Sutton; Joanna E Brewer; Emma Gostick; Giovanna Bossi; Bruno Laugel; Ruth Moysey; Emma Baston; Nathaniel Liddy; Brian Cameron; Alan D Bennett; Rebecca Ashfield; Anita Milicic; David A Price; Brendan J Classon; Andrew K Sewell; Bent K Jakobsen
The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor.
Molecular cancer therapeutics 2007;6(7):2081-91.
2007: Keri L Schaubert; David A Price; Nicole Frahm; Jinzhu Li; Hwee Ng; Aviva Joseph; Elyse Paul; Biswanath Majumder; Velpandi Ayyavoo; Emma Gostick; Sharon Adams; Francesco M Marincola; Andrew K Sewell; Marcus Altfeld; Jason M Brenchley; Daniel C Douek; Otto O Yang; Christian Brander; Harris Goldstein; June Kan-Mitchell
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7756-66.
2007: david cole; Nicholas Pumphrey; Jonathan M Boulter; malkit sami; John I Bell; Emma Gostick; David A Price; George F Gao; Andrew K Sewell; Bent K Jakobsen
Human TCR-binding affinity is governed by MHC class restriction.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5727-34.
2007: Linda Wooldridge; Anna Lissina; Jonathan Vernazza; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Mirza Fareed; P Rod Dunbar; Jonathan M Boulter; Meir Glick; Vincenzo Cerundolo; Hugo A van den Berg; David A Price; Andrew K Sewell
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
European journal of immunology 2007;37(5):1323-33.
2007: Bruno Laugel; David A Price; Anita Milicic; Andrew K Sewell
CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions.
European journal of immunology 2007;37(4):905-13.
2007: Jonathan M Boulter; Nicole Schmitz; Andrew K Sewell; Andrew J Godkin; Martin F Bachmann; Awen Gallimore
Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.
European journal of immunology 2007;37(3):798-806.
2007: Malcolm S Mitchell; Teri A Lund; Andrew K Sewell; Francesco M Marincola; Elyse Paul; Kim Schroder; Darcy B Wilson; June Kan-Mitchell
The cytotoxic T cell response to peptide analogs of the HLA-A*0201-restricted MUC1 signal sequence epitope, M1.2.
Cancer immunology, immunotherapy : CII 2007;56(3):287-301.
2007: Emma Gostick; david cole; Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Anna Lissina; Annette Oxenius; Jonathan M Boulter; David A Price; Andrew K Sewell
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
European journal of immunology 2007;37(2):479-86.
2006: Vicki Fleming; Edward J Feil; Andrew K Sewell; Nicholas Day; Angus Buckling; Ruth C Massey
Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.
Journal of bacteriology 2006;188(21):7686-8.
2006: Linda Wooldridge; Thomas J Scriba; Anita Milicic; Bruno Laugel; Emma Gostick; David A Price; Rodney E Phillips; Andrew K Sewell
Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers.
European journal of immunology 2006;36(7):1847-55.
2006: Bruno Laugel; David A Price; Andrew K Sewell
On the path to TCR-directed therapeutics.
Nature biotechnology 2006;24(6):615-6.
2005: Katayoun Rezvani; Jason M Brenchley; David A Price; Yasemin Kilical; Emma Gostick; Andrew K Sewell; Jongming Li; Stephan Mielke; Daniel C Douek; A John Barrett
T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8799-807.
2005: David A Price; Jason M Brenchley; Laura E Ruff; Michael R Betts; Brenna J Hill; Mario Roederer; Richard A Koup; Stephen A Migueles; Emma Gostick; Linda Wooldridge; Andrew K Sewell; Mark Connors; Daniel C Douek
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.
The Journal of experimental medicine 2005;202(10):1349-61.
2005: Thomas J Scriba; Marco A Purbhoo; Cheryl L Day; Nicola Robinson; Sarah Fidler; Julie Fox; Jonathan N Weber; Paul Klenerman; Andrew K Sewell; Rodney E Phillips
Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6334-43.
2005: Anita Milicic; David A Price; Peter Zimbwa; Bruce L Booth; Helen L Brown; Philippa J Easterbrook; Kara Olsen; Nicola Robinson; Uzi Gileadi; Andrew K Sewell; Vincenzo Cerundolo; Rodney E Phillips
CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4618-26.
2005: Peter Molloy; Andrew K Sewell; Bent K Jakobsen
Soluble T cell receptors: novel immunotherapies.
Current opinion in pharmacology 2005;5(4):438-43.
2005: Linda Wooldridge; Hugo A van den Berg; Meir Glick; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Anita Milicic; Jason M Brenchley; Daniel C Douek; David A Price; Andrew K Sewell
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
The Journal of biological chemistry 2005;280(30):27491-501.
2005: Alasdair Leslie; Daniel Kavanagh; Isobella Honeyborne; Katja Pfafferott; Charles Edwards; Tilly Pillay; Louise Hilton; Christina Thobakgale; Danni Ramduth; Rika Draenert; Sylvie Le Gall; Graz Luzzi; Anne Edwards; Christian Brander; Andrew K Sewell; Sarah Moore; James Mullins; Corey Moore; Simon Mallal; Nina Bhardwaj; Karina Yusim; Rodney Phillips; Paul Klenerman; Bette Korber; Photini Kiepiela; Bruce Walker; Philip J R Goulder
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
The Journal of experimental medicine 2005;201(6):891-902.
2005: Bruno Laugel; Jonathan M Boulter; Nikolai M Lissin; Annelise Vuidepot; Yi Li; Emma Gostick; Laura E Crotty; Daniel C Douek; Joris Hemelaar; David A Price; Bent K Jakobsen; Andrew K Sewell
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
The Journal of biological chemistry 2005;280(3):1882-92.
2005: R E Hewitt; Anna Lissina; A E Green; E S Slay; David A Price; Andrew K Sewell
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins.
Clinical and experimental immunology 2005;139(1):101-11.
2004: A E Green; Anna Lissina; Sarah L Hutchinson; R E Hewitt; B Temple; D James; Jonathan M Boulter; David A Price; Andrew K Sewell
Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin.
Clinical and experimental immunology 2004;136(3):472-82.
2003: Linda Wooldridge; Sarah L Hutchinson; Ed Man-Lik Choi; Anna Lissina; Emma Jones; Mirza Fareed; P Rod Dunbar; David A Price; Vincenzo Cerundolo; Andrew K Sewell
Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6650-60.
2003: Ed Man-Lik Choi; Ji-Li Chen; Linda Wooldridge; Mariolina Salio; Anna Lissina; Nikolai M Lissin; Ian F Hermans; Jonathan Silk; Mirza Fareed; Michael J Palmowski; P Rod Dunbar; Bent K Jakobsen; Andrew K Sewell; Vincenzo Cerundolo
High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5116-23.
2003: Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Meir Glick; Jonathan M Boulter; Bent K Jakobsen; David A Price; Andrew K Sewell
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.
The Journal of biological chemistry 2003;278(27):24285-93.
2002: Annette Oxenius; Andrew K Sewell; Sara J Dawson; Huldrych Günthard; Marek Fischer; Geraldine M Gillespie; Sarah L Rowland-Jones; Catherine Fagard; Bernard Hirschel; Rodney E Phillips; David A Price
Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load.
Journal of clinical immunology 2002;22(6):363-74.
2002: Meir Glick; David A Price; Annelise Vuidepot; Torben B Andersen; Sarah L Hutchinson; Bruno Laugel; Andrew K Sewell; Jonathan M Boulter; P Rod Dunbar; Vincenzo Cerundolo; Annette Oxenius; John I Bell; W Graham Richards; Bent K Jakobsen
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
The Journal of biological chemistry 2002;277(23):20840-6.
2002: Anthony D Kelleher; Andrew K Sewell; David A Price
Dyslipidemia due to retroviral protease inhibitors.
Nature medicine 2002;8(4):308; author reply 308-9.
2002: Andrew K Sewell; Bruce L Booth; Vincenzo Cerundolo; Rodney E Phillips; David A Price
Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.
Viral immunology 2002;15(1):193-6.
2001: Marco A Purbhoo; Jonathan M Boulter; David A Price; Annelise Vuidepot; Christopher Hourigan; P Rod Dunbar; Kara Olson; Sara J Dawson; Rodney E Phillips; Bent K Jakobsen; John I Bell; Andrew K Sewell
The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.
The Journal of biological chemistry 2001;276(35):32786-92.
2001: Anthony D Kelleher; Bruce L Booth; Andrew K Sewell; A Oxenius; Vincenzo Cerundolo; Andrew J McMichael; Rodney E Phillips; David A Price
Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
AIDS research and human retroviruses 2001;17(11):1063-6.
2001: Xiao-Ning Xu; Marco A Purbhoo; N Chen; Juthathip Mongkolsapaya; J H Cox; UC Meier; Sabrina Tafuro; P Rod Dunbar; Andrew K Sewell; Christopher Hourigan; Victor Appay; Vincenzo Cerundolo; S R Burrows; Andrew J McMichael; Gavin Screaton
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.
Immunity 2001;14(5):591-602.
2001: Annette Oxenius; David A Price; Sara J Dawson; Tin Tun; Philippa J Easterbrook; Rodney E Phillips; Andrew K Sewell
Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens.
AIDS (London, England) 2001;15(1):121-2.
2000: C L Lin; Andrew K Sewell; G F Gao; K T Whelan; Rodney E Phillips; Jonathan M Austyn
Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis.
The Journal of experimental medicine 2000;192(4):587-94.
2000: Annette Oxenius; David A Price; Philippa J Easterbrook; Christopher A O'Callaghan; Anthony D Kelleher; JA Whelan; G Sontag; Andrew K Sewell; Rodney E Phillips
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3382-7.
2000: Andrew K Sewell; David A Price; A Oxenius; A D Kelleher; R E Phillips
Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.
Stem cells (Dayton, Ohio) 2000;18(4):230-44.
1999: Uzi Gileadi; HT Moins-Teisserenc; I Correa; Bruce L Booth; P Rod Dunbar; Andrew K Sewell; J Trowsdale; Rodney E Phillips; Vincenzo Cerundolo
Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6045-52.
1999: JA Whelan; P Rod Dunbar; David A Price; Marco A Purbhoo; Franziska Lechner; Graham S Ogg; G Griffiths; Rodney E Phillips; Vincenzo Cerundolo; Andrew K Sewell
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4342-8.
1999: Andrew K Sewell; David A Price; H Teisserenc; Bruce L Booth; Uzi Gileadi; F M Flavin; J Trowsdale; Rodney E Phillips; Vincenzo Cerundolo
IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7075-9.
1999: David A Price; P Klenerman; Bruce L Booth; Rodney E Phillips; Andrew K Sewell
Cytotoxic T lymphocytes, chemokines and antiviral immunity.
Immunology today 1999;20(5):212-6.
1999: Andrew K Sewell; UC Gerth; David A Price; Marco A Purbhoo; Jonathan M Boulter; George F Gao; John I Bell; Rodney E Phillips; Bent K Jakobsen
Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
Nature medicine 1999;5(4):399-404.
1998: David A Price; UC Meier; Paul Klenerman; Marco A Purbhoo; Rodney E Phillips; Andrew K Sewell
The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection.
Journal of molecular medicine (Berlin, Germany) 1998;76(10):699-708.
1998: JD Wilson; Graham S Ogg; Rachel Allen; Philip J R Goulder; Anthony D Kelleher; Andrew K Sewell; Christopher A O'Callaghan; Sarah L Rowland-Jones; Margaret F C Callan; Andrew J McMichael
Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.
The Journal of experimental medicine 1998;188(4):785-90.
1998: Marco A Purbhoo; Andrew K Sewell; Paul Klenerman; P J Goulder; K L Hilyard; John I Bell; Bent K Jakobsen; Rodney E Phillips
Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4527-32.
1998: David A Price; Andrew K Sewell; Tao Dong; R Tan; P J Goulder; Sarah L Rowland-Jones; Rodney E Phillips
Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes.
Current biology : CB 1998;8(6):355-8.
1997: Andrew K Sewell; Gillian Harcourt; Philip J R Goulder; David A Price; Rodney E Phillips
Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides.
European journal of immunology 1997;27(9):2323-9.
1997: Philip J R Goulder; Andrew K Sewell; David Lalloo; David A Price; JA Whelan; J Evans; G P Taylor; Graz Luzzi; P Giangrande; Rodney E Phillips; Andrew J McMichael
Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation.
The Journal of experimental medicine 1997;185(8):1423-33.
1997: David A Price; Philip J R Goulder; Paul Klenerman; Andrew K Sewell; Philippa J Easterbrook; M Troop; Charles R M Bangham; Rodney E Phillips
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1890-5.