Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
NetworkView
Leonard Seymour
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles
free of charge to researchers worldwide.
Research Profile (preview)
Chemicals & Drugs
Procedures
Living Beings
Physiology
Devices
Anatomy
Concepts & Ideas
Sign-in to see full Profile
Network (preview)
32
Ulbrich, Karel
23
Fisher, Kerry
17
Read, Martin
14
Kerr, David
11
Oupicky, David
11
Green, Nicola
10
Dash, Philip
10
Subr, Vladimir
9
Carlisle, Robert
9
Stevenson, Mark
9
Mautner, Vivien
8
Oupický, David
8
Parker, Alan
8
Duncan, Ruth
8
Wolfert, MA
Sign-in to see all Coauthors
Publications
Sign-in to see all Publications
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
Geonetwork of Leonard Seymour (preview)
Cities where this author has publications
Cities where co-authors of this author have publications
Sign-in to see more
All Publications
-
2009: Liu W-l; Green N; Seymour L W; Stevenson M
Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma.
Cancer gene therapy 2009;16(10):764-75.
-
2009: El-Sherbini Yasser M; Stevenson Mark M; Seymour Leonard W; Wade-Martins Richard
Quantitative characterization of cell transduction by HSV-1 amplicons using flow cytometry and real-time PCR.
Journal of virological methods 2009;159(2):160-6.
-
2009: Seymour Leonard W; Ferry David R; Kerr David J; Rea Daniel; Whitlock Maggie; Poyner Richard; Boivin Christopher; Hesslewood Stuart; Twelves Christopher; Blackie Robert; Schatzlein Andreas; Jodrell Duncan; Bissett Donald; Calvert Hilary; Lind Mike; Robbins Adele; Burtles Sally; Duncan Ruth; Cassidy James
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer.
International journal of oncology 2009;34(6):1629-36.
-
2009: Cawood Ryan; Chen Hannah H; Carroll Fionnadh; Bazan-Peregrino Miriam; van Rooijen Nico; Seymour Leonard W
Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells.
PLoS pathogens 2009;5(5):e1000440.
-
2009: Sims Karen; Ahmed Zubair; Read Martin L; Cooper-Charles Lisa; Gonzalez Ana Maria; Fisher Kerry D; Berry Martin; Seymour Leonard W; Logan Ann
In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones.
The journal of gene medicine 2009;11(4):335-44.
-
2009: Morrison Joanne; Briggs Simon S; Green Nicola K; Thoma Clemens; Fisher Kerry D; Kehoe Sean; Seymour Leonard W
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.
Human gene therapy 2009;20(3):239-51.
-
2009: Carlisle Robert C; Di Ying; Cerny Anna M; Sonnen Andreas F-P; Sim Robert B; Green Nicola K; Subr Vladimir; Ulbrich Karel; Gilbert Robert J C; Fisher Kerry D; Finberg Robert W; Seymour Leonard W
Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.
Blood 2009;113(9):1909-18.
-
2009: Liu Wei-li; Stevenson Mark; Seymour Leonard W; Fisher Kerry D
Quantification of siRNA using competitive qPCR.
Nucleic acids research 2009;37(1):e4.
-
2009: Liu Wei-Li; Owen Douglas P; Fisher Kerry D; Seymour Leonard W; Stevenson Mark
Establishment of a positive-readout reporter system for siRNAs.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 2009;5(1):331-8.
-
2008: Bazan-Peregrino M; Carlisle R C; Hernandez-Alcoceba R; Iggo R; Homicsko K; Fisher K D; Halldén G; Mautner V; Shen Y; Seymour L W
Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus.
Human gene therapy 2008;19(9):873-86.
-
2008: Seymour Leonard W; Cawood Ryan; Fisher Kerry D
Cellular carriers or free viruses?
Current opinion in molecular therapeutics 2008;10(4):321-2.
-
2008: Stevenson Mark; Ramos-Perez Victor; Singh Surjeet; Soliman Mahmoud; Preece Jon A; Briggs Simon S; Read Martin L; Seymour Leonard W
Delivery of siRNA mediated by histidine-containing reducible polycations.
Journal of controlled release : official journal of the Controlled Release Society 2008;130(1):46-56.
-
2008: Nasanit Rujikan; Iqbal Parvez; Soliman Mahmoud; Spencer Neil; Allen Stephanie; Davies Martyn C; Briggs Simon S; Seymour Leonard W; Preece Jon A; Alexander Cameron
Combination dual responsive polypeptide vectors for enhanced gene delivery.
Molecular bioSystems 2008;4(7):741-5.
-
2008: Bazan-Peregrino M; Carlisle R C; Purdie L; Seymour L W
Factors influencing retention of adenovirus within tumours following direct intratumoural injection.
Gene therapy 2008;15(9):688-94.
-
2008: Carlisle Robert C; Benjamin Reuben; Briggs Simon S; Sumner-Jones Stephanie; McIntosh Jenny; Gill Deborah; Hyde Steve; Nathwani Amit; Subr Vladimir; Ulbrich Karel; Seymour Leonard W; Fisher Kerry D
Coating of adeno-associated virus with reactive polymers can ablate virus tropism, enable retargeting and provide resistance to neutralising antisera.
The journal of gene medicine 2008;10(4):400-11.
-
2008: Green Nicola K; Morrison Joanne; Hale Sarah; Briggs Simon S; Stevenson Mark; Subr Vladimir; Ulbrich Karel; Chandler Lois; Mautner Vivien; Seymour Leonard W; Fisher Kerry D
Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer.
The journal of gene medicine 2008;10(3):280-9.
-
2008: Morrison Joanne; Briggs Simon S; Green Nicola; Fisher Kerry; Subr Vladimir; Ulbrich Karel; Kehoe Sean; Seymour Leonard W
Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):244-51.
-
2007: Fisher Kerry D; Green Nicola K; Hale Ashley; Subr Vladimir; Ulbrich Karel; Seymour Leonard W
Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy.
Journal of drug targeting 2007;15(7-8):546-51.
-
2007: Maruta Fukuto; Akita Noriyuki; Nakayama Jun; Miyagawa Shinichi; Ismail Tariq; Rowlands David C; Kerr David J; Fisher Kerry D; Seymour Leonard W; Parker Alan L
Bacteriophage biopanning in human tumour biopsies to identify cancer-specific targeting ligands.
Journal of drug targeting 2007;15(4):311-9.
-
2007: Stevenson M; Hale A B H; Hale S J; Green N K; Black G; Fisher K D; Ulbrich K; Fabra A; Seymour L W
Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins.
Cancer gene therapy 2007;14(4):335-45.
-
2007: Bazan-Peregrino M; Seymour L W; Harris A L
Gene therapy targeting to tumor endothelium.
Cancer gene therapy 2007;14(2):117-27.
-
2006: Carlisle R C; Briggs S S; Hale A B; Green N K; Fisher K D; Etrych T; Ulbrich K; Mautner V; Seymour L W
Use of synthetic vectors for neutralising antibody resistant delivery of replicating adenovirus DNA.
Gene therapy 2006;13(22):1579-86.
-
2006: Akita Noriyuki; Maruta Fukuto; Seymour Leonard W; Kerr David J; Parker Alan L; Asai Tomohiro; Oku Naoto; Nakayama Jun; Miyagawa Shinichi
Identification of oligopeptides binding to peritoneal tumors of gastric cancer.
Cancer science 2006;97(10):1075-81.
-
2006: Seymour Leonard W
The future of gene therapy in the UK.
Trends in biotechnology 2006;24(8):347-9.
-
2006: Lyons Mark; Onion David; Green Nicky K; Aslan Kriss; Rajaratnam Ratna; Bazan-Peregrino Miriam; Phipps Sue; Hale Sarah; Mautner Vivien; Seymour Leonard W; Fisher Kerry D
Adenovirus type 5 interactions with human blood cells may compromise systemic delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(1):118-28.
-
2006: Shimizu Akira; Maruta Fukuto; Akita Noriyuki; Miwa Shiro; Seymour Leonard W; Kerr David J; Parker Alan L; Miyagawa Shinichi
Identification of an oligopeptide binding to hepatocellular carcinoma.
Oncology 2006;71(1-2):136-45.
-
2006: Farrow Paul J; Barrett Lee B; Stevenson Mark; Fisher Kerry D; Finn Jonathan; Spice Rachel; Allan Michael A; Berry Martin; Logan Ann; Seymour Leonard W; Read Martin L
Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons.
Nucleic acids research 2006;34(11):e80.
-
2005: Zhou Qing-Hui; Miller Douglas L; Carlisle Robert C; Seymour Leonard W; Oupicky David
Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.
Journal of controlled release : official journal of the Controlled Release Society 2005;106(3):416-27.
-
2005: Pearce Oliver M T; Fisher Kerry D; Humphries Julia; Seymour Leonard W; Smith Alberto; Davis Benjamin G
Glycoviruses: chemical glycosylation retargets adenoviral gene transfer.
Angewandte Chemie (International ed. in English) 2005;44(7):1057-61.
-
2005: De Winne Katleen; Seymour Leonard W; Schacht Etienne H
Synthesis and in vitro evaluation of macromolecular antitumour derivatives based on phenylenediamine mustard.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(2-3):159-68.
-
2005: Parker Alan L; Fisher Kerry D; Oupicky David; Read Martin L; Nicklin Stuart A; Baker Andrew H; Seymour Leonard W
Enhanced gene transfer activity of peptide-targeted gene-delivery vectors.
Journal of drug targeting 2005;13(1):39-51.
-
2005: Read Martin L; Logan Ann; Seymour Leonard W
Barriers to gene delivery using synthetic vectors.
Advances in genetics 2005;53():19-46.
-
2005: Read Martin L; Singh Surjeet; Ahmed Zubair; Stevenson Mark; Briggs Simon S; Oupicky David; Barrett Lee B; Spice Rachel; Kendall Mark; Berry Martin; Preece Jon A; Logan Ann; Seymour Leonard W
A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.
Nucleic acids research 2005;33(9):e86.
-
2004: Howard Kenneth A; Li Xiong Wei; Somavarapu Satyanarayana; Singh Jasvinder; Green Nicky; Atuah Kwame N; Ozsoy Yildiz; Seymour Leonard W; Alpar H Oya
Formulation of a microparticle carrier for oral polyplex-based DNA vaccines.
Biochimica et biophysica acta 2004;1674(2):149-57.
-
2004: Green N K; Herbert C W; Hale S J; Hale A B; Mautner V; Harkins R; Hermiston T; Ulbrich K; Fisher K D; Seymour L W
Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus.
Gene therapy 2004;11(16):1256-63.
-
2004: Barrett L B; Berry M; Ying W-B; Hodgkin M N; Seymour L W; Gonzalez A-M; Read M L; Baird A; Logan A
CTb targeted non-viral cDNA delivery enhances transgene expression in neurons.
The journal of gene medicine 2004;6(4):429-38.
-
2004: Carlisle Robert C; Etrych Tomas; Briggs Simon S; Preece Jon A; Ulbrich Karel; Seymour Leonard W
Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.
The journal of gene medicine 2004;6(3):337-44.
-
2004: Bremner K Helen; Seymour Leonard W; Logan Ann; Read Martin L
Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery.
Bioconjugate chemistry 2004;15(1):152-61.
-
2003: Kerr D J; Seymour L W; Maruta F
Gene therapy for colorectal cancer.
Expert opinion on biological therapy 2003;3(5):779-88.
-
2003: Read Martin L; Farrow Paul J; Seymour Leonard W
Emerging developments in RNA therapeutics.
Expert opinion on therapeutic targets 2003;7(2):299-303.
-
2003: Read Martin L; Bremner K Helen; Oupický David; Green Nicola K; Searle Peter F; Seymour Leonard W
Vectors based on reducible polycations facilitate intracellular release of nucleic acids.
The journal of gene medicine 2003;5(3):232-45.
-
2003: Maruta Fukuto; Parker Alan L; Fisher Kerry D; Murray Paul G; Kerr David J; Seymour Leonard W
Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veins.
Journal of drug targeting 2003;11(1):53-9.
-
2003: Seymour L W; Fisher K D; Green N K; Hale S J; Lyons M; Mautner V; Nicum S; Onion D; Oupicky D; Stevenson M; Ulbrich K
Adenovirus retargeting and systemic delivery.
Ernst Schering Research Foundation workshop 2003;(43):107-14.
-
2002: Green Nicola K; Seymour Leonard W
Adenoviral vectors: systemic delivery and tumor targeting.
Cancer gene therapy 2002;9(12):1036-42.
-
2002: Ward Christopher M; Pechar Michal; Oupicky David; Ulbrich Karel; Seymour Leonard W
Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo.
The journal of gene medicine 2002;4(5):536-47.
-
2002: Maruta Fukuto; Parker Alan L; Fisher Kerry D; Hallissey Michael T; Ismail Tariq; Rowlands David C; Chandler Lois A; Kerr David J; Seymour Leonard W
Identification of FGF receptor-binding peptides for cancer gene therapy.
Cancer gene therapy 2002;9(6):543-52.
-
2002: Reschel Tomás; Konák Cestmír; Oupický David; Seymour Leonard W; Ulbrich Karel
Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):201-17.
-
2002: Oupicky David; Ogris Manfred; Howard Kenneth A; Dash Philip R; Ulbrich Karel; Seymour Leonard W
Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):463-72.
-
2002: Oupický David; Ogris Manfred; Seymour Leonard W
Development of long-circulating polyelectrolyte complexes for systemic delivery of genes.
Journal of drug targeting 2002;10(2):93-8.
-
2002: Seymour Leonard W; Ferry David R; Anderson David; Hesslewood Stuart; Julyan Peter J; Poyner Richard; Doran Jayne; Young Annie M; Burtles Sally; Kerr David J;
Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1668-76.
-
2002: Parker Alan L; Oupicky David; Dash Philip R; Seymour Leonard W
Methodologies for monitoring nanoparticle formation by self-assembly of DNA with poly(l-lysine).
Analytical biochemistry 2002;302(1):75-80.
-
2002: Oupický David; Parker Alan L; Seymour Leonard W
Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors.
Journal of the American Chemical Society 2002;124(1):8-9.
-
2001: Ogris M; Carlisle R C; Bettinger T; Seymour L W
Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors.
The Journal of biological chemistry 2001;276(50):47550-5.
-
2001: Carlisle R C; Bettinger T; Ogris M; Hale S; Mautner V; Seymour L W
Adenovirus hexon protein enhances nuclear delivery and increases transgene expression of polyethylenimine/plasmid DNA vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(5):473-83.
-
2001: Bettinger T; Carlisle R C; Read M L; Ogris M; Seymour L W
Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells.
Nucleic acids research 2001;29(18):3882-91.
-
2001: Atkinson S F; Bettinger T; Seymour L W; Behr J P; Ward C M
Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells.
The Journal of biological chemistry 2001;276(30):27930-5.
-
2001: Oupický D; Carlisle R C; Seymour L W
Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.
Gene therapy 2001;8(9):713-24.
-
2001: Bremner K H; Seymour L W; Pouton C W
Harnessing nuclear localization pathways for transgene delivery.
Current opinion in molecular therapeutics 2001;3(2):170-7.
-
2001: Ward C M; Read M L; Seymour L W
Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy.
Blood 2001;97(8):2221-9.
-
2001: Fisher K D; Stallwood Y; Green N K; Ulbrich K; Mautner V; Seymour L W
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.
Gene therapy 2001;8(5):341-8.
-
2001: Mulholland P J; Ferry D R; Anderson D; Hussain S A; Young A M; Cook J E; Hodgkin E; Seymour L W; Kerr D J
Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(2):245-8.
-
2000: Fisher K D; Ulbrich K; Subr V; Ward C M; Mautner V; Blakey D; Seymour L W
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression.
Gene therapy 2000;7(15):1337-43.
-
2000: Howard K A; Dash P R; Read M L; Ward K; Tomkins L M; Nazarova O; Ulbrich K; Seymour L W
Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.
Biochimica et biophysica acta 2000;1475(3):245-55.
-
2000: Oupický D; Howard K A; Konák C; Dash P R; Ulbrich K; Seymour L W
Steric stabilization of poly-L-Lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
Bioconjugate chemistry 2000;11(4):492-501.
-
2000: Read M L; Dash P R; Clark A; Howard K A; Oupicky D; Toncheva V; Alpar H O; Schacht E H; Ulbrich K; Seymour L W
Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):169-77.
-
2000: Pechar M; Ulbrich K; Subr V; Seymour L W; Schacht E H
Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin.
Bioconjugate chemistry 2000;11(2):131-9.
-
2000: Dekie L; Toncheva V; Dubruel P; Schacht E H; Barrett L; Seymour L W
Poly-L-glutamic acid derivatives as vectors for gene therapy.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):187-202.
-
2000: Oupický D; Konák C; Ulbrich K; Wolfert M A; Seymour L W
DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):149-71.
-
2000: Dash P R; Read M L; Fisher K D; Howard K A; Wolfert M; Oupicky D; Subr V; Strohalm J; Ulbrich K; Seymour L W
Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin.
The Journal of biological chemistry 2000;275(6):3793-802.
-
2000: Ward C M; Acheson N; Seymour L W
Folic acid targeting of protein conjugates into ascites tumour cells from ovarian cancer patients.
Journal of drug targeting 2000;8(2):119-23.
-
1999: Barrett L B; Logan A; Berry M; Ying W; Gonzalez A M; Baird A; Seymour L W
Targeted transfection of neuronal cells using a poly(D-lysine)-cholera-toxin b chain conjugate.
Biochemical Society transactions 1999;27(6):851-7.
-
1999: Wolfert M A; Dash P R; Nazarova O; Oupicky D; Seymour L W; Smart S; Strohalm J; Ulbrich K
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.
Bioconjugate chemistry 1999;10(6):993-1004.
-
1999: Read M L; Etrych T; Ulbrich K; Seymour L W
Characterisation of the binding interaction between poly(L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors.
FEBS letters 1999;461(1-2):96-100.
-
1999: Oupický D; Konák C; Dash P R; Seymour L W; Ulbrich K
Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block.
Bioconjugate chemistry 1999;10(5):764-72.
-
1999: Anderson D; Ferry D R; Knox R J; Andrews S J; Downes A J; Kerr D J; Seymour L W
High-performance liquid chromatographic method for sensitive determination of the alkylating agent CB1954 in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 1999;731(2):293-8.
-
1999: Dash P R; Read M L; Barrett L B; Wolfert M A; Seymour L W
Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery.
Gene therapy 1999;6(4):643-50.
-
1999: Soyez H; Seymour L W; Schacht E
Macromolecular derivatives of N,N-di-(2-chloroethyl)-4-phenylene diamine mustard. 2. In vitro cytotoxicity and in vivo anticancer efficacy.
Journal of controlled release : official journal of the Controlled Release Society 1999;57(2):187-96.
-
1999: Julyan P J; Seymour L W; Ferry D R; Daryani S; Boivin C M; Doran J; David M; Anderson D; Christodoulou C; Young A M; Hesslewood S; Kerr D J
Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine.
Journal of controlled release : official journal of the Controlled Release Society 1999;57(3):281-90.
-
1998: Seymour L W; Olliff S P; Poole C J; De Takats P G; Orme R; Ferry D R; Maeda H; Konno T; Kerr D J
A novel dosage approach for evaluation of SMANCS [poly-(styrene-co-maleyl-half-n-butylate) - neocarzinostatin] in the treatment of primary hepatocellular carcinoma.
International journal of oncology 1998;12(6):1217-23.
-
1998: Toncheva V; Wolfert M A; Dash P R; Oupicky D; Ulbrich K; Seymour L W; Schacht E H
Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.
Biochimica et biophysica acta 1998;1380(3):354-68.
-
1998: Wolfert M A; Seymour L W
Chloroquine and amphipathic peptide helices show synergistic transfection in vitro.
Gene therapy 1998;5(3):409-14.
-
1997: Anderson D; Kerr D J; Blesing C; Seymour L W
Simultaneous gas chromatographic-mass spectrophotometric determination of alpha-fluoro-beta-alanine and 5-fluorouracil in plasma.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(1):87-93.
-
1996: Wolfert M A; Schacht E H; Toncheva V; Ulbrich K; Nazarova O; Seymour L W
Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers.
Human gene therapy 1996;7(17):2123-33.
-
1996: Seymour L W; Shoaibi M A; Martin A; Ahmed A; Elvin P; Kerr D J; Wakelam M J
Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells.
Laboratory investigation; a journal of technical methods and pathology 1996;75(3):427-37.
-
1996: Seymour L W; Soyez H; De Marre A; Shoaibi M A; Schacht E H
Polymeric prodrugs of mitomycin C designed for tumour tropism and sustained activation.
Anti-cancer drug design 1996;11(5):351-65.
-
1996: Wolfert M A; Seymour L W
Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA.
Gene therapy 1996;3(3):269-73.
-
1995: Seymour L W; Miyamoto Y; Maeda H; Brereton M; Strohalm J; Ulbrich K; Duncan R
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):766-70.
-
1994: Seymour L W; Ulbrich K; Steyger P S; Brereton M; Subr V; Strohalm J; Duncan R
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.
British journal of cancer 1994;70(4):636-41.
-
1991: Seymour L W; Ulbrich K; Wedge S R; Hume I C; Strohalm J; Duncan R
N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
British journal of cancer 1991;63(6):859-66.
-
1991: Yeung T K; Hopewell J W; Simmonds R H; Seymour L W; Duncan R; Bellini O; Grandi M; Spreafico F; Strohalm J; Ulbrich K
Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.
Cancer chemotherapy and pharmacology 1991;29(2):105-11.
-
1991: Seymour L W; Flanagan P A; al-Shamkhani A; Subr V; Ulbrich K; Cassidy J; Duncan R
Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery.
Selective cancer therapeutics 1991;7(2):59-73.
-
1990: Seymour L W; Ulbrich K; Strohalm J; Kopecek J; Duncan R
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
-
1987: Seymour L W; Duncan R; Kopecková P; Kopecek J
Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Cancer treatment reviews 1987;14(3-4):319-27.
-
1987: Seymour L W; Duncan R; Strohalm J; Kopecek J
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Journal of biomedical materials research 1987;21(11):1341-58.
Sign-in to see more
