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Georgia Sfyroera

Research Profile

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

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Protein Binding

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Enzyme-Linked Immunosorbent Assay

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Publications

TOP 3
Edimara S Reis; Daniel Ricklin; Georgia Sfyroera; Hui Chen; Jörg Köhl; Peter N Monk; John D Lambris
C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.
You-Qiang Wu; Hongchang Qu; Georgia Sfyroera; Apostolia Tzekou; Brian Kay; Bo Nilsson; Kristina Nilsson-Ekdahl; Daniel Ricklin; John D Lambris
Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine.
H Chen; Daniel Ricklin; Michal Hammel; Brandon L Garcia; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; Apostolia Tzekou; Sheng Li; Brian V Geisbrecht; Virgil L Woods; John D Lambris
Allosteric inhibition of complement function by a staphylococcal immune evasion protein.

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All Publications

2012: Edimara S Reis; Daniel Ricklin; Georgia Sfyroera; Hui Chen; Jörg Köhl; Peter N Monk; John D Lambris
C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4797-805.
2011: You-Qiang Wu; Hongchang Qu; Georgia Sfyroera; Apostolia Tzekou; Brian Kay; Bo Nilsson; Kristina Nilsson-Ekdahl; Daniel Ricklin; John D Lambris
Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4269-77.
2010: H Chen; Daniel Ricklin; Michal Hammel; Brandon L Garcia; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; Apostolia Tzekou; Sheng Li; Brian V Geisbrecht; Virgil L Woods; John D Lambris
Allosteric inhibition of complement function by a staphylococcal immune evasion protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17621-6.
2010: Robert Silasi-Mansat; Hua Zhu; Narcis I Popescu; Glenn Peer; Georgia Sfyroera; Paola Magotti; Lacramioara Ivanciu; Cristina Lupu; Tom E Mollnes; Fletcher B Taylor; Gary T Kinasewitz; John D Lambris; Florea Lupu
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis.
Blood 2010;116(6):1002-10.
2010: Ebbe Billmann Thorgersen; Judith K Ludviksen; John D Lambris; Georgia Sfyroera; Erik Waage Nielsen; Tom Eirik Mollnes
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity.
Innate immunity 2010;16(4):254-64.
2009: Daniel Ricklin; Apostolia Tzekou; Brandon L Garcia; Michal Hammel; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; V Michael Holers; Andrew Herbert; Paul N Barlow; Brian V Geisbrecht; John D Lambris
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2565-74.
2009: Ebbe Billmann Thorgersen; Anne Pharo; Karin Haverson; Anne K Axelsen; Peter Gaustad; Girish J Kotwal; Georgia Sfyroera; Tom Eirik Mollnes
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
Infection and immunity 2009;77(2):725-32.
2008: Michael C Schuster; Daniel Ricklin; Krisztián Papp; Kathleen S Molnar; Stephen J Coales; Yoshitomo Hamuro; Georgia Sfyroera; Hui Chen; Michael S Winters; John D Lambris
Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry.
Molecular immunology 2008;45(11):3142-51.
2008: Hui Chen; Michael C Schuster; Georgia Sfyroera; Brian V Geisbrecht; John D Lambris
Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2008;19(1):55-65.
2007: Michal Hammel; Georgia Sfyroera; Serapion Pyrpassopoulos; Daniel Ricklin; Kasra X Ramyar; Mihai Pop; Zhongmin Jin; John D Lambris; Brian V Geisbrecht
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus.
The Journal of biological chemistry 2007;282(41):30051-61.
2007: Xinhua Zhang; Yuko Kimura; Chongyun Fang; Lin Zhou; Georgia Sfyroera; John D Lambris; Rick A Wetsel; Takashi Miwa; Wen-Chao Song
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.
Blood 2007;110(1):228-36.
2007: Michal Hammel; Georgia Sfyroera; Daniel Ricklin; Paola Magotti; John D Lambris; Brian V Geisbrecht
A structural basis for complement inhibition by Staphylococcus aureus.
Nature immunology 2007;8(4):430-7.
2007: Erik Waage Nielsen; Christian Waage; Hilde Fure; Ole-Lars Brekke; Georgia Sfyroera; John D Lambris; Tom Eirik Mollnes
Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement.
Molecular immunology 2007;44(8):1819-26.
2007: Maria Rosaria Pinto; Daniela Melillo; Stefano Giacomelli; Georgia Sfyroera; John D Lambris
Ancient origin of the complement system: emerging invertebrate models.
Advances in experimental medicine and biology 2007;598():372-88.
2006: Daniela Melillo; Georgia Sfyroera; Rosaria De Santis; Rita Graziano; Rita Marino; John D Lambris; Maria Rosaria Pinto
First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):4132-40.
2006: Madan Katragadda; Paola Magotti; Georgia Sfyroera; John D Lambris
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.
Journal of medicinal chemistry 2006;49(15):4616-22.
2006: Athena Soulika; M Claire H Holland; Georgia Sfyroera; Arvind Sahu; John D Lambris
Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3.
Molecular immunology 2006;43(12):2023-9.
2006: Scott M Drouin; Meenal Sinha; Georgia Sfyroera; John D Lambris; Rick A Wetsel
A protective role for the fifth complement component (c5) in allergic airway disease.
American journal of respiratory and critical care medicine 2006;173(8):852-7.
2006: Jörg Köhl; Ralf Baelder; Ian Lewkowich; Manoj K Pandey; Heiko Hawlisch; Lihua Wang; Jennifer Best; Nancy S Herman; Alyssa A Sproles; Jörg Zwirner; Jeffrey A Whitsett; Craig Gerard; Georgia Sfyroera; John D Lambris; MARSHA WILLS-KARP
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
The Journal of clinical investigation 2006;116(3):783-96.
2005: Petros A Kokkinos; Alexandra Kazantzi; Georgia Sfyroera; Ioannis K Zarkadis
Molecular cloning of leukocyte cell-derived chemotaxin 2 in rainbow trout.
Fish & shellfish immunology 2005;18(5):371-80.
2005: Georgia Sfyroera; Madan Katragadda; Dimitrios Morikis; Stuart N Isaacs; John D Lambris
Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2143-51.
2004: Edward Bell; Mohammad Shamim; J Charles Whitbeck; Georgia Sfyroera; John D Lambris; Stuart N Isaacs
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin.
Virology 2004;325(2):425-31.
2004: Jung-Won Park; Christian Taube; Anthony Joetham; Katsuyuki Takeda; Taku Kodama; Azzeddine Dakhama; Glen McConville; Corrie B Allen; Georgia Sfyroera; Leonard D Shultz; John D Lambris; Patricia C Giclas; V Michael Holers; Erwin W Gelfand
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
American journal of respiratory and critical care medicine 2004;169(6):726-32.
2003: Stuart N Isaacs; Emelia Argyropoulos; Georgia Sfyroera; Shamim Mohammad; John D Lambris
Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein.
Journal of virology 2003;77(15):8256-62.
2003: Alexandra Kazantzi; Georgia Sfyroera; M Claire H Holland; John D Lambris; Ioannis K Zarkadis
Molecular cloning of the beta subunit of complement component eight of rainbow trout.
Developmental and comparative immunology 2003;27(3):167-74.
2001: Silvia Franchini; Ioannis K Zarkadis; Georgia Sfyroera; Arvind Sahu; WT Moore; Dimitrios Mastellos; Scott E LaPatra; John D Lambris
Cloning and purification of the rainbow trout fifth component of complement (C5).
Developmental and comparative immunology 2001;25(5-6):419-30.
2001: Ioannis K Zarkadis; Maria-Rosa Sarrias; Georgia Sfyroera; J Oriol Sunyer; John D Lambris
Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity.
Developmental and comparative immunology 2001;25(1):11-24.