FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Gerald Shadel

Research Profile

Anatomy

Mitochondrion

Chemicals & Drugs

Living Beings

Physiology

Co-author Network

Publications

TOP 3
Yulia V Surovtseva; Gerald S Shadel
Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.
Anthony D D'Souza; Susan M Kaech; Diane S Krause; Ian A Parish; Gerald S Shadel
Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.
Elizabeth A Schroeder; Gerald S Shadel
Alternative mitochondrial fuel extends life span.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Gerald Shadel (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Yulia V Surovtseva; Gerald S Shadel
Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.
Nucleic acids research 2013;41(4):2479-88.
2013: Anthony D D'Souza; Susan M Kaech; Diane S Krause; Ian A Parish; Gerald S Shadel
Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(1):42-8.
2012: Elizabeth A Schroeder; Gerald S Shadel
Alternative mitochondrial fuel extends life span.
Cell metabolism 2012;15(4):417-8.
2012: Nuno Raimundo; Joseph Santos-Sacchi; Timothy E Shutt; Lei Song; Justin Cotney; Thomas C Gilliland; Min-Xin Guan; David Hohuan; Sharen E McKay; Gerald S Shadel
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
Cell 2012;148(4):716-26.
2012: Christopher Scott Malarkey; Gerald S Shadel; Megan Bestwick; Jane E Kuhlwilm; Mair E A Churchill
Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA.
Nucleic acids research 2012;40(2):614-24.
2011: Lijun Liu; Masato Sanosaka; Gerald S Shadel; Yulia V Surovtseva; Megan L Bestwick; Joseph H Frey; Shi Lei; Marcus P Cooper
LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.
The Journal of biological chemistry 2011;286(48):41253-64.
2011: Bora E Baysal; Tae Hoon Kim; Yoon Jung Kim; Sharen E McKay; Karel Pacak; Joan E Willett-Brozick; Zimei Zhang; Linda Alila; Gerald S Shadel
Genomic imprinting at a boundary element flanking the SDHD locus.
Human molecular genetics 2011;20(22):4452-61.
2011: Yulia V Surovtseva; Timothy E Shutt; Sophia Y Chen; Huseyin Cimen; Justin Cotney; Emine C Koc; Gerald S Shadel
Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(44):17921-6.
2011: Nuno Raimundo; Bora E Baysal; Gerald S Shadel
Revisiting the TCA cycle: signaling to tumor formation.
Trends in molecular medicine 2011;17(11):641-9.
2011: Yong Pan; Elizabeth A Schroeder; Alejandro Ocampo; Antoni Barrientos; Gerald S Shadel
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
Cell metabolism 2011;13(6):668-78.
2011: Anthony D D'Souza; Ian A Parish; Sharen E McKay; Susan M Kaech; Gerald S Shadel
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.
The American journal of pathology 2011;178(6):2740-51.
2011: A Phillip West; Gerald S Shadel; Sankar Ghosh
Mitochondria in innate immune responses.
Nature reviews. Immunology 2011;11(6):389-402.
2011: A Phillip West; Igor E Brodsky; Christoph Rahner; Dong Kyun Woo; Hediye Erdjument-Bromage; Paul Tempst; Matthew C Walsh; Yongwon Choi; Gerald S Shadel; Sankar Ghosh
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
Nature 2011;472(7344):476-80.
2011: Dong Kyun Woo; Gerald S Shadel
Mitochondrial stress signals revise an old aging theory.
Cell 2011;144(1):11-2.
2011: Marc Chatenay-Lapointe; Gerald S Shadel
Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.
PloS one 2011;6(5):e20441.
2010: Hui-Young Lee; Cheol Soo Choi; Andreas L Birkenfeld; Tiago C Alves; François R Jornayvaz; Michael J Jurczak; Dongyan Zhang; Dong Kyun Woo; Gerald S Shadel; Warren Ladiges; Peter S Rabinovitch; Janine H Santos; Kitt F Petersen; Varman T Samuel; Gerald I Shulman
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Cell metabolism 2010;12(6):668-74.
2010: Marc Chatenay-Lapointe; Gerald S Shadel
Stressed-out mitochondria get MAD.
Cell metabolism 2010;12(6):559-60.
2010: Timothy E Shutt; Maria F Lodeiro; Justin Cotney; Craig E Cameron; Gerald S Shadel
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12133-8.
2010: Timothy E Shutt; Gerald S Shadel
A compendium of human mitochondrial gene expression machinery with links to disease.
Environmental and molecular mutagenesis 2010;51(5):360-79.
2009: Maria A Lebedeva; Jana S Eaton; Gerald S Shadel
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis.
Biochimica et biophysica acta 2009;1787(5):328-34.
2009: Nuno Raimundo; Gerald S Shadel
A "radical" mitochondrial view of autophagy-related pathology.
Aging 2009;1(4):354-6.
2009: Michal Caspi Tal; Miwa Sasai; Heung Kyu Lee; Brian Yordy; Gerald S Shadel; Akiko Iwasaki
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2770-5.
2009: Yong Pan; Gerald S Shadel
Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density.
Aging 2009;1(1):131-45.
2009: Lyra M Griffiths; Nicole A Doudican; Gerald S Shadel; Paul W. Doetsch
Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae.
Methods in molecular biology (Clifton, N.J.) 2009;554():267-86.
2008: Gerald S Shadel
Into the wild frontier of mitochondrial disease and aging.
Methods (San Diego, Calif.) 2008;46(4):239-40.
2008: Gerald S Shadel
Debut of MitoMatters.
Mitochondrion 2008;8(4):338.
2008: Nicholas D Bonawitz; Marc Chatenay-Lapointe; Christopher M Wearn; Gerald S Shadel
Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction.
Current genetics 2008;54(2):83-94.
2008: Gerald S Shadel
Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.
The American journal of pathology 2008;172(6):1445-56.
2008: Michael Schleicher; Benjamin R Shepherd; Yajaira Suarez; Carlos Fernandez-Hernando; Jun Yu; Yong Pan; Lisette Acevedo; Gerald S Shadel; William C Sessa
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence.
The Journal of cell biology 2008;180(1):101-12.
2007: Anthony D D'Souza; Neal Parikh; Susan M Kaech; Gerald S Shadel
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation.
Mitochondrion 2007;7(6):374-85.
2007: Jana S Eaton; Z. Ping Lin; Alan C Sartorelli; Nicholas D Bonawitz; Gerald S Shadel
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis.
The Journal of clinical investigation 2007;117(9):2723-34.
2007: Maria A Lebedeva; Gerald S Shadel
Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression.
Cell cycle (Georgetown, Tex.) 2007;6(16):2048-57.
2007: Nicholas D Bonawitz; Gerald S Shadel
Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination.
Cell cycle (Georgetown, Tex.) 2007;6(13):1574-8.
2007: Zhibo Wang; Justin Cotney; Gerald S Shadel
Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.
The Journal of biological chemistry 2007;282(17):12610-8.
2007: Nicholas D Bonawitz; Marc Chatenay-Lapointe; Yong Pan; Gerald S Shadel
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.
Cell metabolism 2007;5(4):265-77.
2007: Z. Ping Lin; Michael F Belcourt; Rocco Carbone; Jana S Eaton; Philip G Penketh; Gerald S Shadel; Joseph G Cory; Alan C Sartorelli
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.
Biochemical pharmacology 2007;73(6):760-72.
2007: Justin Cotney; Zhibo Wang; Gerald S Shadel
Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.
Nucleic acids research 2007;35(12):4042-54.
2007: Gerald S Shadel; Bonnie L Seidel-Rogol
Diagnostic assays for defects in mtDNA replication and transcription in yeast and humans.
Methods in cell biology 2007;80():465-79.
2007: Timothy E Shutt; Gerald S Shadel
Expanding the mitochondrial interactome.
Genome biology 2007;8(2):203.
2006: Nicholas D Bonawitz; David A Clayton; Gerald S Shadel
Initiation and beyond: multiple functions of the human mitochondrial transcription machinery.
Molecular cell 2006;24(6):813-25.
2006: Justin Cotney; Gerald S Shadel
Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.
Journal of molecular evolution 2006;63(5):707-17.
2006: Nicholas D Bonawitz; Matthew S Rodeheffer; Gerald S Shadel
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span.
Molecular and cellular biology 2006;26(13):4818-29.
2005: Thomas W O'Rourke; Nicole A Doudican; Hong Zhang; Jana S Eaton; Paul W. Doetsch; Gerald S Shadel
Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability.
Gene 2005;354():86-92.
2005: Gerald S Shadel
Mitochondrial DNA, aconitase 'wraps' it up.
Trends in biochemical sciences 2005;30(6):294-6.
2005: Nicole A Doudican; Binwei Song; Gerald S Shadel; Paul W. Doetsch
Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.
Molecular and cellular biology 2005;25(12):5196-204.
2005: Sean D Taylor; Hong Zhang; Jana S Eaton; Matthew S Rodeheffer; Maria A Lebedeva; Thomas W O'Rourke; Wolfram Siede; Gerald S Shadel
The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae.
Molecular biology of the cell 2005;16(6):3010-8.
2004: Gerald S Shadel
Coupling the mitochondrial transcription machinery to human disease.
Trends in genetics : TIG 2004;20(10):513-9.
2004: Gerald S Shadel
A dual-function mitochondrial transcription factor tunes out deafness.
Molecular genetics and metabolism 2004;82(1):1-3.
2003: Vicki McCulloch; Gerald S Shadel
Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.
Molecular and cellular biology 2003;23(16):5816-24.
2003: Matthew S Rodeheffer; Gerald S Shadel
Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis.
The Journal of biological chemistry 2003;278(20):18695-701.
2003: Bonnie L Seidel-Rogol; Vicki McCulloch; Gerald S Shadel
Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.
Nature genetics 2003;33(1):23-4.
2002: Paulo S R Coelho; Anthony C Bryan; Anuj Kumar; Gerald S Shadel; Michael Snyder
A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA.
Genes & development 2002;16(21):2755-60.
2002: Thomas W O'Rourke; Nicole A Doudican; Melinda D Mackereth; Paul W. Doetsch; Gerald S Shadel
Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins.
Molecular and cellular biology 2002;22(12):4086-93.
2002: Bonnie L Seidel-Rogol; Gerald S Shadel
Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells.
Nucleic acids research 2002;30(9):1929-34.
2002: Vicki McCulloch; Bonnie L Seidel-Rogol; Gerald S Shadel
A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.
Molecular and cellular biology 2002;22(4):1116-25.
2002: Anthony C Bryan; Matthew S Rodeheffer; Christopher M Wearn; Gerald S Shadel
Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression.
Genetics 2002;160(1):75-82.
2001: Matthew S Rodeheffer; B E Boone; Anthony C Bryan; Gerald S Shadel
Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase.
The Journal of biological chemistry 2001;276(11):8616-22.
2001: Bonnie L Seidel-Rogol; Gerald S Shadel
Diagnostic assays for defects in mitochondrial DNA replication and transcription in yeast and human cells.
Methods in cell biology 2001;65():413-27.
2000: Gerald S Shadel; G A Buckenmeyer; David A Clayton; Mark E Schmitt
Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes.
Gene 2000;245(1):175-84.
1999: Gerald S Shadel
Yeast as a model for human mtDNA replication.
American journal of human genetics 1999;65(5):1230-7.
1999: Yuhuan Wang; Gerald S Shadel
Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8046-51.
1997: Gerald S Shadel; David A Clayton
Mitochondrial DNA maintenance in vertebrates.
Annual review of biochemistry 1997;66():409-35.