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Juanita Shaffer

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G Andreola; T Bonnefoix; M Chittenden; A Benedict Cosimi; P Cotter; B R Dey; K Kattleman; Tatsuo Kawai; S A Locascio; Tatsuaki Morokata; F Preffer; David H Sachs; Juanita Shaffer; Thomas R Spitzer; N T Tolkoff-Rubin; Megan Sykes
Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation.
F Porcheray; W Wong; Susan Saidman; J De Vito; T C Girouard; M Chittenden; Juanita Shaffer; Nina Tolkoff-Rubin; Bimalangshu R Dey; Thomas R Spitzer; Robert B Colvin; A Benedict Cosimi; Tatsuo Kawai; David H Sachs; Megan Sykes; E Zorn
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
Tatsuo Kawai; A Benedict Cosimi; Thomas R Spitzer; Nina Tolkoff-Rubin; Manikkam Suthanthiran; Susan Saidman; Juanita Shaffer; Frederic Preffer; Ruchuang Ding; Vijay Sharma; Jay A Fishman; Bimalangshu R Dey; Dicken S. C. Ko; Martin Hertl; Nelson Bahia Goes; Waichi Wong; Winfred W Williams; Robert B Colvin; Megan Sykes; David H Sachs
HLA-mismatched renal transplantation without maintenance immunosuppression.

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All Publications

2011: G Andreola; T Bonnefoix; M Chittenden; A Benedict Cosimi; P Cotter; B R Dey; K Kattleman; Tatsuo Kawai; S A Locascio; Tatsuaki Morokata; F Preffer; David H Sachs; Juanita Shaffer; Thomas R Spitzer; N T Tolkoff-Rubin; Megan Sykes
Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(6):1236-47.
2009: F Porcheray; W Wong; Susan Saidman; J De Vito; T C Girouard; M Chittenden; Juanita Shaffer; Nina Tolkoff-Rubin; Bimalangshu R Dey; Thomas R Spitzer; Robert B Colvin; A Benedict Cosimi; Tatsuo Kawai; David H Sachs; Megan Sykes; E Zorn
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(9):2126-35.
2008: Tatsuo Kawai; A Benedict Cosimi; Thomas R Spitzer; Nina Tolkoff-Rubin; Manikkam Suthanthiran; Susan Saidman; Juanita Shaffer; Frederic Preffer; Ruchuang Ding; Vijay Sharma; Jay A Fishman; Bimalangshu R Dey; Dicken S. C. Ko; Martin Hertl; Nelson Bahia Goes; Waichi Wong; Winfred W Williams; Robert B Colvin; Megan Sykes; David H Sachs
HLA-mismatched renal transplantation without maintenance immunosuppression.
The New England journal of medicine 2008;358(4):353-61.
2007: Juanita Shaffer; Jean Villard; Terry K Means; Stephen Alexander; David Dombkowski; Bimalangshu R Dey; Steven McAfee; Karen K Ballen; Susan Saidman; Frederic Preffer; David H Sachs; Thomas R Spitzer; Megan Sykes
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine.
Experimental hematology 2007;35(7):1140-52.
2007: Bimalangshu R Dey; Juanita Shaffer; Andrew J Yee; Steven McAfee; M Caron; K Power; D T Ting; Christine Colby; Frederic Preffer; Karen K Ballen; Eyal C Attar; Susan Saidman; Nancy J Tarbell; David Sachs; Megan Sykes; Thomas R Spitzer
Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen.
Bone marrow transplantation 2007;40(1):19-27.
2006: Yasuhiro Fudaba; Thomas R Spitzer; Juanita Shaffer; Tatsuo Kawai; Thomas Fehr; Francis L Delmonico; Frederic Preffer; Nina Tolkoff-Rubin; Bimalangshu R Dey; Susan Saidman; A Kraus; T Bonnefoix; Steven McAfee; K Power; K Kattleman; Robert B Colvin; David H Sachs; A Benedict Cosimi; Megan Sykes
Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):2121-33.
2006: Hiroshi Ito; Yasuo Takeuchi; Juanita Shaffer; Megan Sykes
Anti-CD40L monoclonal antibodies can replace anti-CD4 monoclonal antibodies for the nonmyeloablative induction of mixed xenogeneic chimerism.
Transplantation 2006;82(2):251-7.
2005: Marie-Therese Rubio; Terry K Means; Ronjon Chakraverty; Juanita Shaffer; Yasuhiro Fudaba; Meredith Chittenden; Andrew D Luster; Megan Sykes
Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs.
International immunology 2005;17(12):1561-72.
2005: Bimalangshu R Dey; Steven McAfee; Christine Colby; Kathy Cieply; Martin Caron; Susan Saidman; Frederic Preffer; Juanita Shaffer; Nancy J Tarbell; Robert Sackstein; David Sachs; Megan Sykes; Thomas R Spitzer
Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation.
British journal of haematology 2005;128(3):351-9.
2004: Josef Kurtz; Juanita Shaffer; Ariadne Lie; Natalie Anosova; Gilles Benichou; Megan Sykes
Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells.
Blood 2004;103(11):4336-43.
2004: Hiroshi Ito; Yasuo Takeuchi; Juanita Shaffer; Megan Sykes
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites.
Blood 2004;103(5):1949-54.
2003: Christian Koenecke; Juanita Shaffer; Stephen I Alexander; Frederic Preffer; David Dombkowski; Susan Saidman; Bimalangshu R Dey; Steven McAfee; Thomas R Spitzer; Megan Sykes
NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507.
Experimental hematology 2003;31(10):911-23.
2003: Annette B Kraus; Juanita Shaffer; Han Chong Toh; Frederic Preffer; David Dombkowski; Susan Saidman; Christine Colby; Richard George; Steven McAfee; Robert Sackstein; Bimalangshu R Dey; Thomas R Spitzer; Megan Sykes
Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation.
Experimental hematology 2003;31(7):609-21.
2003: Josef Kurtz; Ariadne Lie; Mathew Griffith; Shannon Eysaman; Juanita Shaffer; Natalie Anosova; Laurence A Turka; Gilles Benichou; Megan Sykes
Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):804-16.
2003: Thomas R Spitzer; Steven McAfee; Bimalangshu R Dey; Christine Colby; James Hope; Howard Grossberg; Frederic Preffer; Juanita Shaffer; Stephen I Alexander; David H Sachs; Megan Sykes
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.
Transplantation 2003;75(10):1748-51.
2001: Paul S Russell; Catharine M Chase; Megan Sykes; Hiroshi Ito; Juanita Shaffer; Robert B Colvin
Tolerance, mixed chimerism, and chronic transplant arteriopathy.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5731-40.
2001: Josef Kurtz; Hiroshi Ito; Thomas Wekerle; Juanita Shaffer; Megan Sykes
Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(4):339-49.
2001: Hiroshi Ito; Josef Kurtz; Juanita Shaffer; Megan Sykes
CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):2970-81.
2001: Thomas Wekerle; Josef Kurtz; Mohamed H Sayegh; Hiroshi Ito; A Wells; S Bensinger; Juanita Shaffer; Laurence A Turka; Megan Sykes
Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2311-6.
2001: Yong Zhao; Jose-Ignacio Rodriguez-Barbosa; Guiling Zhao; Juanita Shaffer; J Scott Arn; Megan Sykes
Maturation and function of mouse T-cells with a transgenic TCR positively selected by highly disparate xenogeneic porcine MHC.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(1):217-28.
2000: Thomas Wekerle; Josef Kurtz; Hiroshi Ito; J V Ronquillo; Victor M Dong; Guiling Zhao; Juanita Shaffer; Mohamed H Sayegh; Megan Sykes
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.
Nature medicine 2000;6(4):464-9.