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Avigdor Shafferman

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Shahar Rotem; Avigdor Shafferman; Uri Elia; Erez Bar-Haim; Raphael Ber; Hila Cohen; Ofer Cohen
Consequences of delayed ciprofloxacin and doxycycline treatment regimens against Francisella tularensis airway infection.
Adva Mechaly; Arie Ordentlich; Ronit Rosenfeld; Avigdor Shafferman; Einat Ben-Arie; Eyal Epstein; Haim Levy; Hadar Marcus; Ohad Mazor
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.
Haim Levy; Josef Schlomovitz; Avigdor Shafferman; Assa Sittner; Shay Weiss; Zeev Altboum; Itai Glinert; David Kobiler
Differential contribution of Bacillus anthracis toxins to pathogenicity in two animal models.

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2012: Shahar Rotem; Avigdor Shafferman; Uri Elia; Erez Bar-Haim; Raphael Ber; Hila Cohen; Ofer Cohen
Consequences of delayed ciprofloxacin and doxycycline treatment regimens against Francisella tularensis airway infection.
Antimicrobial agents and chemotherapy 2012;56(10):5406-8.
2012: Adva Mechaly; Arie Ordentlich; Ronit Rosenfeld; Avigdor Shafferman; Einat Ben-Arie; Eyal Epstein; Haim Levy; Hadar Marcus; Ohad Mazor
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.
The Journal of biological chemistry 2012;287(39):32665-73.
2012: Haim Levy; Josef Schlomovitz; Avigdor Shafferman; Assa Sittner; Shay Weiss; Zeev Altboum; Itai Glinert; David Kobiler
Differential contribution of Bacillus anthracis toxins to pathogenicity in two animal models.
Infection and immunity 2012;80(8):2623-31.
2012: Yaron Vagima; Eran Zahavy; Ayelet Zauberman; Avigdor Shafferman; Avital Tidhar; Hagar Abramovich; Moshe Aftalion; Yehuda Flashner; David Gur; Yinon Levy; Emanuelle Mamroud
Early sensing of Yersinia pestis airway infection by bone marrow cells.
Frontiers in cellular and infection microbiology 2012;2():143.
2012: Tomer Israely; Shlomo Lustig; Nir Paran; Boaz Politi; Avigdor Shafferman; Noam Erez; Sharon Melamed
A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease.
Virology journal 2012;9():119.
2012: Anat Zvi; Ofer Cohen; Shahar Rotem; Avigdor Shafferman
Clusters versus affinity-based approaches in F. tularensis whole genome search of CTL epitopes.
PloS one 2012;7(5):e36440.
2011: Yinon Levy; Avigdor Shafferman; Avital Tidhar; Ayelet Zauberman; Moshe Aftalion; Yehuda Flashner; David Gur; Shirley Lazar; Emanuelle Mamroud
T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague.
Vaccine 2011;29(40):6866-73.
2011: Theodor Chitlaru; Ofer Cohen; Sharon Ehrlich; Itzhak Inbar; Galia Zaide; Avigdor Shafferman
HtrA is a major virulence determinant of Bacillus anthracis.
Molecular microbiology 2011;81(6):1542-59.
2011: Galia Zaide; Haim Grosfeld; Sharon Ehrlich; Anat Zvi; Ofer Cohen; Avigdor Shafferman
Identification and characterization of novel and potent transcription promoters of Francisella tularensis.
Applied and environmental microbiology 2011;77(5):1608-18.
2011: Anat Zvi; Shahar Rotem; Erez Bar-Haim; Ofer Cohen; Avigdor Shafferman
Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response.
PloS one 2011;6(5):e20050.
2011: Theodor Chitlaru; Zeev Altboum; Shaul Reuveny; Avigdor Shafferman
Progress and novel strategies in vaccine development and treatment of anthrax.
Immunological reviews 2011;239(1):221-36.
2010: Chanoch Kronman; Ofer Cohen; Ohad Mazor; Arie Ordentlich; Lily Raveh; Baruch Velan; Avigdor Shafferman
Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics.
Chemico-biological interactions 2010;187(1-3):253-8.
2010: Gal Markel; Erez Bar-Haim; Eran Zahavy; Hila Cohen; Ofer Cohen; Avigdor Shafferman; Baruch Velan
The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
PloS one 2010;5(6):e11176.
2009: Theodor Chitlaru; Avigdor Shafferman
Proteomic studies of Bacillus anthracis.
Future microbiology 2009;4(8):983-98.
2009: Sagit Sela-Abramovich; Theodor Chitlaru; Orit Gat; Haim Grosfeld; Ofer Cohen; Avigdor Shafferman
Novel and unique diagnostic biomarkers for Bacillus anthracis infection.
Applied and environmental microbiology 2009;75(19):6157-67.
2009: Shlomo Lustig; Galia Maik-Rachline; Nir Paran; Sharon Melamed; Tomer Israely; Noam Erez; Nadav Orr; Shaul Reuveny; Arie Ordentlich; Orgad Laub; Avigdor Shafferman; Baruch Velan
Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.
Vaccine 2009;27(11):1691-9.
2009: Avital Tidhar; Yehuda Flashner; Sara Cohen; Yinon Levi; Ayelet Zauberman; David Gur; Moshe Aftalion; Eytan Elhanany; Anat Zvi; Avigdor Shafferman; Emanuelle Mamroud
The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague.
PloS one 2009;4(9):e7023.
2009: Ayelet Zauberman; Avital Tidhar; Yinon Levy; Erez Bar-Haim; Gideon Halperin; Yehuda Flashner; Sara Cohen; Avigdor Shafferman; Emanuelle Mamroud
Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.
PloS one 2009;4(6):e5938.
2009: Nir Paran; Yasemin Suezer; Shlomo Lustig; Tomer Israely; Astrid Schwantes; Sharon Melamed; Lior Katz; Thomas Preuss; Kay-Martin Hanschmann; Ulrich Kalinke; Noam Erez; Reuven Levin; Baruch Velan; Johannes Löwer; Avigdor Shafferman; Gerd Sutter
Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox.
The Journal of infectious diseases 2009;199(1):39-48.
2009: Dov Barak; Arie Ordentlich; Dana Stein; Qian-Sheng Yu; Nigel H Greig; Avigdor Shafferman
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.
The Biochemical journal 2009;417(1):213-22.
2008: Erez Bar-Haim; Orit Gat; Gal Markel; Hila Cohen; Avigdor Shafferman; Baruch Velan
Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection.
PLoS pathogens 2008;4(11):e1000211.
2008: Orit Gat; Galia Zaide; Itzhak Inbar; Haim Grosfeld; Theodor Chitlaru; Haim Levy; Avigdor Shafferman
Characterization of Bacillus anthracis iron-regulated surface determinant (Isd) proteins containing NEAT domains.
Molecular microbiology 2008;70(4):983-99.
2008: Avigdor Shafferman; Dov Barak; Dana Stein; Chanoch Kronman; Baruch Velan; Nigel H Greig; Arie Ordentlich
Flexibility versus "rigidity" of the functional architecture of AChE active center.
Chemico-biological interactions 2008;175(1-3):166-72.
2008: Ohad Mazor; Ofer Cohen; Chanoch Kronman; Lily Raveh; Dana Stein; Arie Ordentlich; Avigdor Shafferman
Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Molecular pharmacology 2008;74(3):755-63.
2008: Ayelet Zauberman; Sara Cohen; Yinon Levy; Gideon Halperin; Shirley Lazar; Baruch Velan; Avigdor Shafferman; Yehuda Flashner; Emanuelle Mamroud
Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague.
Vaccine 2008;26(13):1616-25.
2008: Anat Zvi; Naomi Ariel; John Fulkerson; Jerald C Sadoff; Avigdor Shafferman
Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.
BMC medical genomics 2008;1():18.
2007: Ofer Cohen; Chanoch Kronman; Arie Lazar; Baruch Velan; Avigdor Shafferman
Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.
The Journal of biological chemistry 2007;282(49):35491-501.
2007: Theodor Chitlaru; Orit Gat; Haim Grosfeld; Itzhak Inbar; Yael Gozlan; Avigdor Shafferman
Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome.
Infection and immunity 2007;75(6):2841-52.
2007: Chanoch Kronman; Ofer Cohen; Lily Raveh; Ohad Mazor; Arie Ordentlich; Avigdor Shafferman
Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication.
Toxicology 2007;233(1-3):40-6.
2007: Ayelet Zauberman; Baruch Velan; Emanuelle Mamroud; Yehuda Flashner; Avigdor Shafferman; Sara Cohen
Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
Advances in experimental medicine and biology 2007;603():312-20.
2007: Orit Gat; Haim Grosfeld; Avigdor Shafferman
In vitro screen of bioinformatically selected Bacillus anthracis vaccine candidates by coupled transcription, translation, and immunoprecipitation analysis.
Methods in molecular biology (Clifton, N.J.) 2007;375():211-33.
2006: Baruch Velan; Erez Bar-Haim; Ayelet Zauberman; Emanuelle Mamroud; Avigdor Shafferman; Sara Cohen
Discordance in the effects of Yersinia pestis on the dendritic cell functions manifested by induction of maturation and paralysis of migration.
Infection and immunity 2006;74(11):6365-76.
2006: Ofer Cohen; Chanoch Kronman; Lily Raveh; Ohad Mazor; Arie Ordentlich; Avigdor Shafferman
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Molecular pharmacology 2006;70(3):1121-31.
2006: Orit Gat; Haim Grosfeld; Naomi Ariel; Itzhak Inbar; Galia Zaide; Yehoshua Broder; Anat Zvi; Theodor Chitlaru; Zeev Altboum; Dana Stein; Sara Cohen; Avigdor Shafferman
Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.
Infection and immunity 2006;74(7):3987-4001.
2006: Ayelet Zauberman; Sara Cohen; Emanuelle Mamroud; Yehuda Flashner; Avital Tidhar; Raphael Ber; Eytan Elhanany; Avigdor Shafferman; Baruch Velan
Interaction of Yersinia pestis with macrophages: limitations in YopJ-dependent apoptosis.
Infection and immunity 2006;74(6):3239-50.
2006: Theodor Chitlaru; Orit Gat; Yael Gozlan; Naomi Ariel; Avigdor Shafferman
Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities.
Journal of bacteriology 2006;188(10):3551-71.
2006: Weiming Luo; Qian-Sheng Yu; Santosh S Kulkarni; Damon Parrish; Harold W Holloway; David Tweedie; Avigdor Shafferman; Debomoy K Lahiri; Arnold Brossi; Nigel H Greig
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Journal of medicinal chemistry 2006;49(7):2174-85.
2005: Dov Barak; Arie Ordentlich; Dana Kaplan; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.
Chemico-biological interactions 2005;157-158():219-26.
2005: Chanoch Kronman; Ofer Cohen; Baruch Velan; Avigdor Shafferman
Host-regulated disposition of mammalian AChEs.
Chemico-biological interactions 2005;157-158():51-5.
2005: Arie Ordentlich; Dov Barak; Gali Sod-Moriah; Dana Kaplan; Dana Mizrahi; Yoffi Segall; Chanoch Kronman; Yishai Karton; Arie Lazar; Dino Marcus; Baruch Velan; Avigdor Shafferman
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.
Chemico-biological interactions 2005;157-158():191-8.
2005: Avigdor Shafferman; Dov Barak; Dana Kaplan; Arie Ordentlich; Chanoch Kronman; Baruch Velan
Functional requirements for the optimal catalytic configuration of the AChE active center.
Chemico-biological interactions 2005;157-158():123-31.
2005: Gil Zomber; Shaul Reuveny; Nissim Garti; Avigdor Shafferman; Eytan Elhanany
Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.
The Journal of biological chemistry 2005;280(48):39897-906.
2005: Itai Mendelson; Orit Gat; R Aloni-Grinstein; Zeev Altboum; Itzhak Inbar; Chanoch Kronman; Erez Bar-Haim; Sara Cohen; Baruch Velan; Avigdor Shafferman
Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.
Vaccine 2005;23(48-49):5688-97.
2005: Orit Gat; Itai Mendelson; Theodor Chitlaru; Naomi Ariel; Zeev Altboum; Haim Levy; Shay Weiss; Haim Grosfeld; Sara Cohen; Avigdor Shafferman
The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant.
Molecular microbiology 2005;58(2):533-51.
2005: R Aloni-Grinstein; Orit Gat; Zeev Altboum; Baruch Velan; Sara Cohen; Avigdor Shafferman
Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen.
Infection and immunity 2005;73(7):4043-53.
2005: Joel Bozue; Narayanan Parthasarathy; Lawrence R Phillips; Christopher K Cote; Patricia F Fellows; Itai Mendelson; Avigdor Shafferman; Arthur M Friedlander
Construction of a rhamnose mutation in Bacillus anthracis affects adherence to macrophages but not virulence in guinea pigs.
Microbial pathogenesis 2005;38(1):1-12.
2004: Nadav Orr; Moshe Forman; Hadar Marcus; Shlomo Lustig; Nir Paran; Itamar Grotto; Eyal Klement; Yoav Yehezkelli; Guy Robin; Shaul Reuveny; Avigdor Shafferman; Dani Cohen
Clinical and immune responses after revaccination of israeli adults with the Lister strain of vaccinia virus.
The Journal of infectious diseases 2004;190(7):1295-302.
2004: Arie Ordentlich; Dov Barak; Gali Sod-Moriah; Dana Kaplan; Dana Mizrahi; Yoffi Segall; Chanoch Kronman; Yishai Karton; Arie Lazar; Dino Marcus; Baruch Velan; Avigdor Shafferman
Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.
Biochemistry 2004;43(35):11255-65.
2004: Itai Mendelson; Steve Tobery; Angelo Scorpio; Joel Bozue; Avigdor Shafferman; Arthur M Friedlander
The NheA component of the non-hemolytic enterotoxin of Bacillus cereus is produced by Bacillus anthracis but is not required for virulence.
Microbial pathogenesis 2004;37(3):149-54.
2004: Hadar Marcus; Rachel Danieli; Eyal Epstein; Baruch Velan; Avigdor Shafferman; Shaul Reuveny
Contribution of immunological memory to protective immunity conferred by a Bacillus anthracis protective antigen-based vaccine.
Infection and immunity 2004;72(6):3471-7.
2004: Dana Kaplan; Dov Barak; Arie Ordentlich; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?
Biochemistry 2004;43(11):3129-36.
2004: Theodor Chitlaru; Naomi Ariel; Anat Zvi; Menahem Lion; Baruch Velan; Avigdor Shafferman; Eytan Elhanany
Identification of chromosomally encoded membranal polypeptides of Bacillus anthracis by a proteomic analysis: prevalence of proteins containing S-layer homology domains.
Proteomics 2004;4(3):677-91.
2004: Ofer Cohen; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta).
The Biochemical journal 2004;378(Pt 1):117-28.
2004: Yehuda Flashner; Emanuelle Mamroud; Avital Tidhar; Raphael Ber; Moshe Aftalion; David Gur; Shirley Lazar; Anat Zvi; Tamar Bino; Naomi Ariel; Baruch Velan; Avigdor Shafferman; Sara Cohen
Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.
Infection and immunity 2004;72(2):908-15.
2003: Naomi Ariel; Anat Zvi; K S Makarova; Theodor Chitlaru; Eytan Elhanany; Baruch Velan; Sara Cohen; Arthur M Friedlander; Avigdor Shafferman
Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens.
Infection and immunity 2003;71(8):4563-79.
2003: Orit Gat; Itzhak Inbar; R Aloni-Grinstein; Eran Zahavy; Chanoch Kronman; Itai Mendelson; Sara Cohen; Baruch Velan; Avigdor Shafferman
Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines.
Infection and immunity 2003;71(2):801-13.
2003: Emanuelle Mamroud; Yehuda Flashner; Avital Tidhar; Raphael Ber; David Gur; Moshe Aftalion; Shirley Lazar; Baruch Velan; Avigdor Shafferman; Sara Cohen
Evaluation of protective immunity induced by Yersinia enterocolitica type-III secretion system mutants.
Advances in experimental medicine and biology 2003;529():425-30.
2003: Haim Grosfeld; Tamar Bino; Yehuda Flashner; Raphael Ber; Emanuelle Mamroud; Shlomo Lustig; Baruch Velan; Avigdor Shafferman; Sara Cohen
Vaccination with plasmid DNA expressing the Yersinia pestis capsular protein F1 protects mice against plague.
Advances in experimental medicine and biology 2003;529():423-4.
2003: Yehuda Flashner; Emanuelle Mamroud; Avital Tidhar; Raphael Ber; Moshe Aftalion; David Gur; Anat Zvi; Naomi Ariel; Baruch Velan; Avigdor Shafferman; Sara Cohen
Identification of genes involved in Yersinia pestis virulence by signature-tagged mutagenesis.
Advances in experimental medicine and biology 2003;529():31-3.
2003: Haim Grosfeld; Sara Cohen; Tamar Bino; Yehuda Flashner; Raphael Ber; Emanuelle Mamroud; Chanoch Kronman; Avigdor Shafferman; Baruch Velan
Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen.
Infection and immunity 2003;71(1):374-83.
2002: Naomi Ariel; Anat Zvi; Haim Grosfeld; Orit Gat; Y Inbar; Baruch Velan; Sara Cohen; Avigdor Shafferman
Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening.
Infection and immunity 2002;70(12):6817-27.
2002: Cécile Cléry-Barraud; Arie Ordentlich; Haim Grosfeld; Avigdor Shafferman; Patrick Masson
Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability.
European journal of biochemistry / FEBS 2002;269(17):4297-307.
2002: Dov Barak; Dana Kaplan; Arie Ordentlich; Naomi Ariel; Baruch Velan; Avigdor Shafferman
The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.
Biochemistry 2002;41(26):8245-52.
2002: Theodor Chitlaru; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time.
The Biochemical journal 2002;363(Pt 3):619-31.
2001: Ofer Cohen; Chanoch Kronman; Theodor Chitlaru; Arie Ordentlich; Baruch Velan; Avigdor Shafferman
Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.
The Biochemical journal 2001;357(Pt 3):795-802.
2001: Eytan Elhanany; Arie Ordentlich; O Dgany; Dana Kaplan; Yoffi Segall; R Barak; Baruch Velan; Avigdor Shafferman
Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts.
Chemical research in toxicology 2001;14(7):912-8.
2001: Dana Kaplan; Arie Ordentlich; Dov Barak; Naomi Ariel; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Biochemistry 2001;40(25):7433-45.
2001: Shaul Reuveny; M D White; Y Y Adar; Y Kafri; Zeev Altboum; Yehoshua Gozes; David Kobiler; Avigdor Shafferman; Baruch Velan
Search for correlates of protective immunity conferred by anthrax vaccine.
Infection and immunity 2001;69(5):2888-93.
2001: Theodor Chitlaru; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Effect of human acetylcholinesterase subunit assembly on its circulatory residence.
The Biochemical journal 2001;354(Pt 3):613-25.
2000: G Kryger; Michal Harel; K Giles; Lilly Toker; Baruch Velan; A Lazar; Chanoch Kronman; Dov Barak; Naomi Ariel; Avigdor Shafferman; Israel Silman; Joel Sussman
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
2000: Chanoch Kronman; Theodor Chitlaru; Eytan Elhanany; Baruch Velan; Avigdor Shafferman
Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase.
The Journal of biological chemistry 2000;275(38):29488-502.
2000: Sara Cohen; Itai Mendelson; Zeev Altboum; David Kobiler; Eytan Elhanany; Tamar Bino; M Leitner; Itzhak Inbar; H Rosenberg; Yehoshua Gozes; R Barak; Morly Fisher; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax.
Infection and immunity 2000;68(8):4549-58.
2000: Dov Barak; Arie Ordentlich; Dana Kaplan; R Barak; Dana Mizrahi; Chanoch Kronman; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.
Biochemistry 2000;39(5):1156-61.
1999: Charles B Millard; G Kryger; Arie Ordentlich; Harry M Greenblatt; Michal Harel; Maria L Raves; Yoffi Segall; Dov Barak; Avigdor Shafferman; Israel Silman; Joel Sussman
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
1999: S Malany; N Baker; M Verweyst; RA Medhekar; Daniel M Quinn; Baruch Velan; Chanoch Kronman; Avigdor Shafferman
Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition.
Chemico-biological interactions 1999;119-120():99-110.
1999: Israel Silman; Charles B Millard; Arie Ordentlich; Harry M Greenblatt; Michal Harel; Dov Barak; Avigdor Shafferman; Joel Sussman
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
1999: Arie Ordentlich; Dov Barak; Chanoch Kronman; Hendrik P Benschop; L P A de Jong; Naomi Ariel; R Barak; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Biochemistry 1999;38(10):3055-66.
1998: Theodor Chitlaru; Chanoch Kronman; Menachem Mendi Zeevi; M Kam; A Harel; Arie Ordentlich; Baruch Velan; Avigdor Shafferman
Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.
The Biochemical journal 1998;336 ( Pt 3)():647-58.
1998: Naomi Ariel; Arie Ordentlich; Dov Barak; Tamar Bino; Baruch Velan; Avigdor Shafferman
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
The Biochemical journal 1998;335 ( Pt 1)():95-102.
1998: Itai Mendelson; Chanoch Kronman; Naomi Ariel; Avigdor Shafferman; Baruch Velan
Bovine acetylcholinesterase: cloning, expression and characterization.
The Biochemical journal 1998;334 ( Pt 1)():251-9.
1998: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Functional characteristics of the oxyanion hole in human acetylcholinesterase.
The Journal of biological chemistry 1998;273(31):19509-17.
1997: Avigdor Shafferman; Arie Ordentlich; Dov Barak; D Stein; Naomi Ariel; Baruch Velan
Aging of somanyl-acetylcholinesterase adducts: facts and models.
The Biochemical journal 1997;324 ( Pt 3)():996-8.
1997: R Barak; Arie Ordentlich; Dov Barak; M Fischer; Hendrik P Benschop; L P A de Jong; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry.
FEBS letters 1997;407(3):347-52.
1996: Baruch Velan; Dov Barak; Naomi Ariel; M Leitner; T Bino; Arie Ordentlich; Avigdor Shafferman
Structural modifications of the omega loop in human acetylcholinesterase.
FEBS letters 1996;395(1):22-8.
1996: Avigdor Shafferman; Arie Ordentlich; Dov Barak; D Stein; Naomi Ariel; Baruch Velan
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.
The Biochemical journal 1996;318 ( Pt 3)():833-40.
1996: H Grosfeld; Dov Barak; Arie Ordentlich; Baruch Velan; Avigdor Shafferman
Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.
Molecular pharmacology 1996;50(3):639-49.
1996: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
The Journal of biological chemistry 1996;271(20):11953-62.
1996: Y Flashner; J Schlomai; Avigdor Shafferman
Three novel plasmid R6K proteins act in concert to distort DNA within the alpha and beta origins of DNA replication.
Molecular microbiology 1996;19(5):985-96.
1996: Avigdor Shafferman; Shlomo Lustig; Y Inbar; Menachem Halevy; P Schneider; T Bino; M Leitner; H Grosfeld; Baruch Velan; F Schödel; S Cohen
Alphavirus hybrid virion vaccines.
Advances in experimental medicine and biology 1996;397():41-7.
1995: M Urh; Y Flashner; Avigdor Shafferman; Marcin Filutowicz
Altered (copy-up) forms of initiator protein pi suppress the point mutations inactivating the gamma origin of plasmid R6K.
Journal of bacteriology 1995;177(23):6732-9.
1995: Dov Barak; Arie Ordentlich; A Bromberg; Chanoch Kronman; D Marcus; A Lazar; Naomi Ariel; Baruch Velan; Avigdor Shafferman
Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.
Biochemistry 1995;34(47):15444-52.
1995: Chanoch Kronman; Baruch Velan; D Marcus; Arie Ordentlich; S Reuveny; Avigdor Shafferman
Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.
The Biochemical journal 1995;311 ( Pt 3)():959-67.
1995: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
The Journal of biological chemistry 1995;270(5):2082-91.
1994: Chanoch Kronman; Arie Ordentlich; Dov Barak; Baruch Velan; Avigdor Shafferman
The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.
The Journal of biological chemistry 1994;269(45):27819-22.
1994: Baruch Velan; Chanoch Kronman; Y Flashner; Avigdor Shafferman
Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase.
The Journal of biological chemistry 1994;269(36):22719-25.
1994: Avigdor Shafferman; Arie Ordentlich; Dov Barak; Chanoch Kronman; R Ber; T Bino; Naomi Ariel; R Osman; Baruch Velan
Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.
The EMBO journal 1994;13(15):3448-55.
1994: Dov Barak; Chanoch Kronman; Arie Ordentlich; Naomi Ariel; A Bromberg; D Marcus; A Lazar; Baruch Velan; Avigdor Shafferman
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
The Journal of biological chemistry 1994;269(9):6296-305.
1994: Yacov Ashani; J Grunwald; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Molecular pharmacology 1994;45(3):555-60.
1993: Baruch Velan; Chanoch Kronman; Arie Ordentlich; Y Flashner; M Leitner; S Cohen; Avigdor Shafferman
N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
The Biochemical journal 1993;296 ( Pt 3)():649-56.
1993: Arie Ordentlich; Chanoch Kronman; Dov Barak; D Stein; Naomi Ariel; D Marcus; Baruch Velan; Avigdor Shafferman
Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
FEBS letters 1993;334(2):215-20.
1993: Mark G Lewis; W R Elkins; Francine E McCutchan; Raoul E Benveniste; C Y Lai; D C Montefiori; Donald S. Burke; G A Eddy; Avigdor Shafferman
Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.
Vaccine 1993;11(13):1347-55.
1993: Arie Ordentlich; Dov Barak; Chanoch Kronman; Y Flashner; M Leitner; Yoffi Segall; Naomi Ariel; S Cohen; Baruch Velan; Avigdor Shafferman
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
The Journal of biological chemistry 1993;268(23):17083-95.
1993: Carl R Alving; Barbara Detrick; Roberta L Richards; Mark G Lewis; Avigdor Shafferman; G A Eddy
Novel adjuvant strategies for experimental malaria and AIDS vaccines.
Annals of the New York Academy of Sciences 1993;690():265-75.
1993: A Kerem; Chanoch Kronman; S Bar-Nun; Avigdor Shafferman; Baruch Velan
Interrelations between assembly and secretion of recombinant human acetylcholinesterase.
The Journal of biological chemistry 1993;268(1):180-4.
1993: Avigdor Shafferman; Mark G Lewis; Francine E McCutchan; Raoul E Benveniste; Peter B Jahrling; Donald S. Burke; G A Eddy
Prevention of transmission of simian immunodeficiency virus from vaccinated macaques that developed transient virus infection following challenge.
Vaccine 1993;11(8):848-52.
1992: Avigdor Shafferman; Baruch Velan; Arie Ordentlich; Chanoch Kronman; H Grosfeld; M Leitner; Y Flashner; S Cohen; Dov Barak; Naomi Ariel
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
The EMBO journal 1992;11(10):3561-8.
1992: Avigdor Shafferman; Chanoch Kronman; Y Flashner; M Leitner; H Grosfeld; Arie Ordentlich; Y Gozes; S Cohen; Naomi Ariel; Dov Barak
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
The Journal of biological chemistry 1992;267(25):17640-8.
1992: Avigdor Shafferman; Mark G Lewis; Francine E McCutchan; Raoul E Benveniste; Peter B Jahrling; R L Hickman; C Y Lai; Donald S. Burke; G A Eddy
Vaccination of macaques with SIV conserved envelope peptides suppressed infection and prevented disease progression and transmission.
AIDS research and human retroviruses 1992;8(8):1483-7.
1992: YJ Rosenberg; Avigdor Shafferman; B D White; S F Papermaster; E Leon; G A Eddy; Raoul E Benveniste; Donald S. Burke; Mark G Lewis
Variation in the CD4+ and CD8+ populations in lymph nodes does not reflect that in the blood during SIVMNE/E11S infection of macaques.
Journal of medical primatology 1992;21(2-3):131-7.
1992: H Grosfeld; Shlomo Lustig; Y Gozes; Baruch Velan; S Cohen; M Leitner; B Lachmi; D Katz; U Olshevski; Avigdor Shafferman
Divergent envelope E2 alphavirus sequences spanning amino acids 297 to 352 induce in mice virus-specific protective immunity and antibodies with complement-mediated cytolytic activity.
Journal of virology 1992;66(2):1084-90.
1991: Baruch Velan; H Grosfeld; Chanoch Kronman; M Leitner; Y Gozes; A Lazar; Y Flashner; D Marcus; S Cohen; Avigdor Shafferman
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.
The Journal of biological chemistry 1991;266(35):23977-84.
1991: Avigdor Shafferman; Peter B Jahrling; Raoul E Benveniste; Mark G Lewis; T J Phipps; F Eden-McCutchan; J Sadoff; G A Eddy; Donald S. Burke
Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7126-30.
1991: H Grosfeld; Baruch Velan; M Leitner; Shlomo Lustig; B E Lachi; S Cohen; Avigdor Shafferman
Delineation of protective epitopes on the E2-envelope glycoprotein of Semliki Forest virus.
Vaccine 1991;9(6):451-6.
1990: Y Flashner; Avigdor Shafferman
Alpha and beta replication origins of plasmid R6K show similar distortions of the DNA helix in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9123-7.
1989: H Grosfeld; Baruch Velan; M Leitner; S Cohen; Shlomo Lustig; B E Lachmi; Avigdor Shafferman
Semliki Forest virus E2 envelope epitopes induce a nonneutralizing humoral response which protects mice against lethal challenge.
Journal of virology 1989;63(8):3416-22.
1989: A Schwers; J E Severin; M Bublot; M Maenhoudt; Paul-Pierre Pastoret; C Vanden Broecke; P Zilimwabagabo; Baruch Velan; S Cohen; Avigdor Shafferman
Protection of cattle from infection with vaccinia virus by bovine interferon alpha C.
The Veterinary record 1989;125(1):15-6.
1989: Avigdor Shafferman; A Layne; J Sadoff; Donald S. Burke; W R Morton; Raoul E Benveniste
Antibody recognition of SIVmac envelope peptides in plasma from macaques experimentally infected with SIV/Mne.
AIDS research and human retroviruses 1989;5(3):327-36.
1989: David Kobiler; H Grosfeld; M Leitner; R Monzain; C Frist; T Seri; S Cohen; Baruch Velan; Avigdor Shafferman; Y Gozes
Production of monoclonal antibodies toward bovine interferons-alpha suitable for immunopurification.
Journal of interferon research 1989;9(2):189-93.
1989: Avigdor Shafferman; Jeffrey Lennox; H Grosfeld; J Sadoff; Robert R Redfield; Donald S. Burke
Patterns of antibody recognition of selected conserved amino acid sequences from the HIV envelope in sera from different stages of HIV infection.
AIDS research and human retroviruses 1989;5(1):33-9.
1987: Avigdor Shafferman; Y Flashner; I Hertman; Y Olami; S Cohen
Molecular aspects of genetic instability of an artificial 68 bp perfect palindrome in Escherichia coli.
Molecular & general genetics : MGG 1987;208(1-2):294-300.
1987: Avigdor Shafferman; Y Flashner; I Hertman; M Lion
Identification and characterization of the functional alpha origin of DNA replication of the R6K plasmid and its relatedness to the R6K beta and gamma origins.
Molecular & general genetics : MGG 1987;208(1-2):263-70.
1987: Avigdor Shafferman; Baruch Velan; S Cohen; M Leitner; H Grosfeld
Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects.
The Journal of biological chemistry 1987;262(13):6227-37.
1986: S Cohen; Baruch Velan; T Bino; H Rosenberg; Avigdor Shafferman
Induction and characterization of bovine leukocyte interferon.
Methods in enzymology 1986;119():136-44.
1986: Baruch Velan; S Cohen; H Grosfeld; Avigdor Shafferman
Isolation of bovine IFN-alpha genes and their expression in bacteria.
Methods in enzymology 1986;119():464-74.
1985: Baruch Velan; S Cohen; H Grosfeld; M Leitner; Avigdor Shafferman
Bovine interferon alpha genes. Structure and expression.
The Journal of biological chemistry 1985;260(9):5498-504.
1985: H Grosfeld; S Cohen; Baruch Velan; Avigdor Shafferman
Genetic engineering of human interferons from lymphoblastoid cells: III. Purification, physicochemical and biological properties of bacterial IFN-alpha J1.
Advances in biotechnological processes 1985;4():59-78.
1985: Avigdor Shafferman; S Cohen; H Grosfeld; M Leitner; Baruch Velan
Genetic engineering of human interferons from lymphoblastoid cells: II. Construction of trp expression plasmids and their use for efficient expression of IFN-alpha J1.
Advances in biotechnological processes 1985;4():25-57.
1985: Baruch Velan; S Cohen; H Grosfeld; Z Shalita; Avigdor Shafferman
Cloning of a bovine interferon-alpha gene subfamily and comparisons between genetically engineered and leukocyte bovine interferons.
Developments in biological standardization 1985;60():355-69.
1985: S Cohen; Baruch Velan; Avigdor Shafferman
Genetic engineering of human interferons from lymphoblastoid cells: I. Cloning of interferon species expressed in Sendai-induced Namalva cells.
Advances in biotechnological processes 1985;4():1-23.
1985: S Cohen; Baruch Velan; H Grosfeld; Z Shalita; M Leitner; Avigdor Shafferman
Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells.
Developments in biological standardization 1985;60():111-22.
1985: Avigdor Shafferman; Y Flashner; I Hertman; R Rein
DNA repair in the in vivo site specific excision of palindromic sequences.
Progress in clinical and biological research 1985;172A():19-36.
1984: H Grosfeld; S Cohen; Baruch Velan; Z Shalita; Avigdor Shafferman
Mutations not altering the symmetrical sequences in the trp operator yield a constitutive phenotype.
Molecular & general genetics : MGG 1984;195(1-2):358-60.
1983: Avigdor Shafferman; Y Flashner; I Hertman
Genetic instability of an artificial palindrom DNA sequence.
Journal of biomolecular structure & dynamics 1983;1(3):729-42.