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Avigdor Shafferman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

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Anatomy

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Physiology

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Anthrax

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Co-Publications
Name
81
Velan, Baruch
44
Kronman, Chanoch
40
Ordentlich, Arie
30
Barak, Dov
28
Ariel, Naomi
19
Cohen, Sara
14
Chitlaru, Theodor
12
Gat, Orit
11
Mamroud, Emanuelle
11
Segall, Yoffi
10
Flashner, Yehuda
10
Grosfeld, Haim
9
Kaplan, Dana
8
Lustig, Shlomo
8
Elhanany, Eytan

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Publications

TOP 3
Chitlaru Theodor; Shafferman Avigdor
Proteomic studies of Bacillus anthracis.
Sela-Abramovich Sagit; Chitlaru Theodor; Gat Orit; Grosfeld Haim; Cohen Ofer; Shafferman Avigdor
Novel and unique diagnostic biomarkers for Bacillus anthracis infection.
Lustig Shlomo; Maik-Rachline Galia; Paran Nir; Melamed Sharon; Israely Tomer; Erez Noam; Orr Nadav; Reuveny Shaul; Ordentlich Arie; Laub Orgad; Shafferman Avigdor; Velan Baruch
Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.

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All Publications

2009: Chitlaru Theodor; Shafferman Avigdor
Proteomic studies of Bacillus anthracis.
Future microbiology 2009;4():983-98.
2009: Sela-Abramovich Sagit; Chitlaru Theodor; Gat Orit; Grosfeld Haim; Cohen Ofer; Shafferman Avigdor
Novel and unique diagnostic biomarkers for Bacillus anthracis infection.
Applied and environmental microbiology 2009;75(19):6157-67.
2009: Lustig Shlomo; Maik-Rachline Galia; Paran Nir; Melamed Sharon; Israely Tomer; Erez Noam; Orr Nadav; Reuveny Shaul; Ordentlich Arie; Laub Orgad; Shafferman Avigdor; Velan Baruch
Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.
Vaccine 2009;27(11):1691-9.
2009: Paran Nir; Suezer Yasemin; Lustig Shlomo; Israely Tomer; Schwantes Astrid; Melamed Sharon; Katz Lior; Preuss Thomas; Hanschmann Kay-Martin; Kalinke Ulrich; Erez Noam; Levin Reuven; Velan Baruch; Löwer Johannes; Shafferman Avigdor; Sutter Gerd
Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox.
The Journal of infectious diseases 2009;199(1):39-48.
2009: Barak Dov; Ordentlich Arie; Stein Dana; Yu Qian-Sheng; Greig Nigel H; Shafferman Avigdor
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.
The Biochemical journal 2009;417(1):213-22.
2009: Tidhar Avital; Flashner Yehuda; Cohen Sara; Levi Yinon; Zauberman Ayelet; Gur David; Aftalion Moshe; Elhanany Eytan; Zvi Anat; Shafferman Avigdor; Mamroud Emanuelle
The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague.
PloS one 2009;4(9):e7023.
2009: Zauberman Ayelet; Tidhar Avital; Levy Yinon; Bar-Haim Erez; Halperin Gideon; Flashner Yehuda; Cohen Sara; Shafferman Avigdor; Mamroud Emanuelle
Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.
PloS one 2009;4(6):e5938.
2008: Bar-Haim Erez; Gat Orit; Markel Gal; Cohen Hila; Shafferman Avigdor; Velan Baruch
Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection.
PLoS pathogens 2008;4(11):e1000211.
2008: Gat Orit; Zaide Galia; Inbar Izhak; Grosfeld Haim; Chitlaru Theodor; Levy Haim; Shafferman Avigdor
Characterization of Bacillus anthracis iron-regulated surface determinant (Isd) proteins containing NEAT domains.
Molecular microbiology 2008;70(4):983-99.
2008: Mazor Ohad; Cohen Ofer; Kronman Chanoch; Raveh Lily; Stein Dana; Ordentlich Arie; Shafferman Avigdor
Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Molecular pharmacology 2008;74(3):755-63.
2008: Shafferman Avigdor; Barak Dov; Stein Dana; Kronman Chanoch; Velan Baruch; Greig Nigel H; Ordentlich Arie
Flexibility versus "rigidity" of the functional architecture of AChE active center.
Chemico-biological interactions 2008;175(1-3):166-72.
2008: Zauberman Ayelet; Cohen Sara; Levy Yinon; Halperin Gideon; Lazar Shirley; Velan Baruch; Shafferman Avigdor; Flashner Yehuda; Mamroud Emanuelle
Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague.
Vaccine 2008;26(13):1616-25.
2008: Zvi Anat; Ariel Naomi; Fulkerson John; Sadoff Jerald C; Shafferman Avigdor
Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.
BMC medical genomics 2008;1():18.
2007: Cohen Ofer; Kronman Chanoch; Lazar Arie; Velan Baruch; Shafferman Avigdor
Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.
The Journal of biological chemistry 2007;282(49):35491-501.
2007: Chitlaru Theodor; Gat Orit; Grosfeld Haim; Inbar Itzhak; Gozlan Yael; Shafferman Avigdor
Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome.
Infection and immunity 2007;75(6):2841-52.
2007: Kronman Chanoch; Cohen Ofer; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication.
Toxicology 2007;233(1-3):40-6.
2007: Zauberman Ayelet; Velan Baruch; Mamroud Emanuelle; Flashner Yehuda; Shafferman Avigdor; Cohen Sara
Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
Advances in experimental medicine and biology 2007;603():312-20.
2007: Gat Orit; Grosfeld Haim; Shafferman Avigdor
In vitro screen of bioinformatically selected Bacillus anthracis vaccine candidates by coupled transcription, translation, and immunoprecipitation analysis.
Methods in molecular biology (Clifton, N.J.) 2007;375():211-33.
2006: Velan Baruch; Bar-Haim Erez; Zauberman Ayelet; Mamroud Emanuelle; Shafferman Avigdor; Cohen Sara
Discordance in the effects of Yersinia pestis on the dendritic cell functions manifested by induction of maturation and paralysis of migration.
Infection and immunity 2006;74(11):6365-76.
2006: Cohen Ofer; Kronman Chanoch; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Molecular pharmacology 2006;70(3):1121-31.
2006: Gat Orit; Grosfeld Haim; Ariel Naomi; Inbar Itzhak; Zaide Galia; Broder Yehoshua; Zvi Anat; Chitlaru Theodor; Altboum Zeev; Stein Dana; Cohen Sara; Shafferman Avigdor
Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.
Infection and immunity 2006;74(7):3987-4001.
2006: Zauberman Ayelet; Cohen Sara; Mamroud Emanuelle; Flashner Yehuda; Tidhar Avital; Ber Raphael; Elhanany Eytan; Shafferman Avigdor; Velan Baruch
Interaction of Yersinia pestis with macrophages: limitations in YopJ-dependent apoptosis.
Infection and immunity 2006;74(6):3239-50.
2006: Chitlaru Theodor; Gat Orit; Gozlan Yael; Ariel Naomi; Shafferman Avigdor
Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities.
Journal of bacteriology 2006;188(10):3551-71.
2006: Luo Weiming; Yu Qian-Sheng; Kulkarni Santosh S; Parrish Damon A; Holloway Harold W; Tweedie David; Shafferman Avigdor; Lahiri Debomoy K; Brossi Arnold; Greig Nigel H
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Journal of medicinal chemistry 2006;49(7):2174-85.
2005: Barak Dov; Ordentlich Arie; Kaplan Dana; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.
Chemico-biological interactions 2005;157-158():219-26.
2005: Kronman Chanoch; Cohen Ofer; Velan Baruch; Shafferman Avigdor
Host-regulated disposition of mammalian AChEs.
Chemico-biological interactions 2005;157-158():51-5.
2005: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.
Chemico-biological interactions 2005;157-158():191-8.
2005: Shafferman Avigdor; Barak Dov; Kaplan Dana; Ordentlich Arie; Kronman Chanoch; Velan Baruch
Functional requirements for the optimal catalytic configuration of the AChE active center.
Chemico-biological interactions 2005;157-158():123-31.
2005: Zomber Gil; Reuveny Shaul; Garti Nissim; Shafferman Avigdor; Elhanany Eytan
Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.
The Journal of biological chemistry 2005;280(48):39897-906.
2005: Mendelson I; Gat O; Aloni-Grinstein R; Altboum Z; Inbar I; Kronman C; Bar-Haim E; Cohen S; Velan B; Shafferman A
Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.
Vaccine 2005;23(48-49):5688-97.
2005: Gat Orit; Mendelson Itai; Chitlaru Theodor; Ariel Naomi; Altboum Zeev; Levy Haim; Weiss Shay; Grosfeld Haim; Cohen Sara; Shafferman Avigdor
The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant.
Molecular microbiology 2005;58(2):533-51.
2005: Aloni-Grinstein R; Gat O; Altboum Z; Velan B; Cohen S; Shafferman A
Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen.
Infection and immunity 2005;73(7):4043-53.
2005: Bozue Joel A; Parthasarathy Narayanan; Phillips Lawrence R; Cote Christopher K; Fellows Patricia F; Mendelson Itai; Shafferman Avigdor; Friedlander Arthur M
Construction of a rhamnose mutation in Bacillus anthracis affects adherence to macrophages but not virulence in guinea pigs.
Microbial pathogenesis 2005;38(1):1-12.
2004: Orr Nadav; Forman Moshe; Marcus Hadar; Lustig Shlomo; Paran Nir; Grotto Itamar; Klement Eyal; Yehezkelli Yoav; Robin Guy; Reuveny Shaul; Shafferman Avigdor; Cohen Dani;
Clinical and immune responses after revaccination of israeli adults with the Lister strain of vaccinia virus.
The Journal of infectious diseases 2004;190(7):1295-302.
2004: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.
Biochemistry 2004;43(35):11255-65.
2004: Mendelson Itai; Tobery Steve; Scorpio Angelo; Bozue Joel; Shafferman Avigdor; Friedlander Arthur M
The NheA component of the non-hemolytic enterotoxin of Bacillus cereus is produced by Bacillus anthracis but is not required for virulence.
Microbial pathogenesis 2004;37(3):149-54.
2004: Marcus Hadar; Danieli Rachel; Epstein Eyal; Velan Baruch; Shafferman Avigdor; Reuveny Shaul
Contribution of immunological memory to protective immunity conferred by a Bacillus anthracis protective antigen-based vaccine.
Infection and immunity 2004;72(6):3471-7.
2004: Kaplan Dana; Barak Dov; Ordentlich Arie; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?
Biochemistry 2004;43(11):3129-36.
2004: Chitlaru Theodor; Ariel Naomi; Zvi Anat; Lion Menahem; Velan Baruch; Shafferman Avigdor; Elhanany Eytan
Identification of chromosomally encoded membranal polypeptides of Bacillus anthracis by a proteomic analysis: prevalence of proteins containing S-layer homology domains.
Proteomics 2004;4(3):677-91.
2004: Flashner Yehuda; Mamroud Emanuelle; Tidhar Avital; Ber Raphael; Aftalion Moshe; Gur David; Lazar Shirley; Zvi Anat; Bino Tamar; Ariel Naomi; Velan Baruch; Shafferman Avigdor; Cohen Sara
Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.
Infection and immunity 2004;72(2):908-15.
2004: Cohen Ofer; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta).
The Biochemical journal 2004;378(Pt 1):117-28.
2003: Ariel N; Zvi A; Makarova K S; Chitlaru T; Elhanany E; Velan B; Cohen S; Friedlander A M; Shafferman A
Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens.
Infection and immunity 2003;71(8):4563-79.
2003: Gat O; Inbar I; Aloni-Grinstein R; Zahavy E; Kronman C; Mendelson I; Cohen S; Velan B; Shafferman A
Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines.
Infection and immunity 2003;71(2):801-13.
2003: Grosfeld Haim; Cohen Sara; Bino Tamar; Flashner Yehuda; Ber Raphael; Mamroud Emanuelle; Kronman Chanoch; Shafferman Avigdor; Velan Baruch
Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen.
Infection and immunity 2003;71(1):374-83.
2003: Mamroud Emanuelle; Flashner Yehuda; Tidhar Avital; Ber Raphael; Gur David; Aftalion Moshe; Lazar Shirley; Velan Baruch; Shafferman Avigdor; Cohen Sara
Evaluation of protective immunity induced by Yersinia enterocolitica type-III secretion system mutants.
Advances in experimental medicine and biology 2003;529():425-30.
2003: Grosfeld Haim; Bino Tamar; Flashner Yehuda; Ber Raphael; Mamroud Emanuelle; Lustig Shlomo; Velan Baruch; Shafferman Avigdor; Cohen Sara
Vaccination with plasmid DNA expressing the Yersinia pestis capsular protein F1 protects mice against plague.
Advances in experimental medicine and biology 2003;529():423-4.
2003: Flashner Yehuda; Mamroud Emanuelle; Tidhar Avital; Ber Raphael; Aftalion Moshe; Gur David; Zvi Anat; Ariel Naomi; Velan Baruch; Shafferman Avigdor; Cohen Sara
Identification of genes involved in Yersinia pestis virulence by signature-tagged mutagenesis.
Advances in experimental medicine and biology 2003;529():31-3.
2002: Ariel N; Zvi A; Grosfeld H; Gat O; Inbar Y; Velan B; Cohen S; Shafferman A
Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening.
Infection and immunity 2002;70(12):6817-27.
2002: Cléry-Barraud Cécile; Ordentlich Arie; Grosfeld Haim; Shafferman Avigdor; Masson Patrick
Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability.
European journal of biochemistry / FEBS 2002;269(17):4297-307.
2002: Barak Dov; Kaplan Dana; Ordentlich Arie; Ariel Naomi; Velan Baruch; Shafferman Avigdor
The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.
Biochemistry 2002;41(26):8245-52.
2002: Chitlaru Theodor; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time.
The Biochemical journal 2002;363(Pt 3):619-31.
2001: Cohen O; Kronman C; Chitlaru T; Ordentlich A; Velan B; Shafferman A
Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.
The Biochemical journal 2001;357(Pt 3):795-802.
2001: Elhanany E; Ordentlich A; Dgany O; Kaplan D; Segall Y; Barak R; Velan B; Shafferman A
Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts.
Chemical research in toxicology 2001;14(7):912-8.
2001: Kaplan D; Ordentlich A; Barak D; Ariel N; Kronman C; Velan B; Shafferman A
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Biochemistry 2001;40(25):7433-45.
2001: Reuveny S; White M D; Adar Y Y; Kafri Y; Altboum Z; Gozes Y; Kobiler D; Shafferman A; Velan B
Search for correlates of protective immunity conferred by anthrax vaccine.
Infection and immunity 2001;69(5):2888-93.
2001: Chitlaru T; Kronman C; Velan B; Shafferman A
Effect of human acetylcholinesterase subunit assembly on its circulatory residence.
The Biochemical journal 2001;354(Pt 3):613-25.
2000: Kryger G; Harel M; Giles K; Toker L; Velan B; Lazar A; Kronman C; Barak D; Ariel N; Shafferman A; Silman I; Sussman J L
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
2000: Kronman C; Chitlaru T; Elhanany E; Velan B; Shafferman A
Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase.
The Journal of biological chemistry 2000;275(38):29488-502.
2000: Cohen S; Mendelson I; Altboum Z; Kobiler D; Elhanany E; Bino T; Leitner M; Inbar I; Rosenberg H; Gozes Y; Barak R; Fisher M; Kronman C; Velan B; Shafferman A
Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax.
Infection and immunity 2000;68(8):4549-58.
2000: Barak D; Ordentlich A; Kaplan D; Barak R; Mizrahi D; Kronman C; Segall Y; Velan B; Shafferman A
Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.
Biochemistry 2000;39(5):1156-61.
1999: Millard C B; Kryger G; Ordentlich A; Greenblatt H M; Harel M; Raves M L; Segall Y; Barak D; Shafferman A; Silman I; Sussman J L
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
1999: Malany S; Baker N; Verweyst M; Medhekar R; Quinn D M; Velan B; Kronman C; Shafferman A
Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition.
Chemico-biological interactions 1999;119-120():99-110.
1999: Silman I; Millard C B; Ordentlich A; Greenblatt H M; Harel M; Barak D; Shafferman A; Sussman J L
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
1999: Ordentlich A; Barak D; Kronman C; Benschop H P; De Jong L P; Ariel N; Barak R; Segall Y; Velan B; Shafferman A
Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Biochemistry 1999;38(10):3055-66.
1998: Chitlaru T; Kronman C; Zeevi M; Kam M; Harel A; Ordentlich A; Velan B; Shafferman A
Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.
The Biochemical journal 1998;336 ( Pt 3)():647-58.
1998: Ariel N; Ordentlich A; Barak D; Bino T; Velan B; Shafferman A
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
The Biochemical journal 1998;335 ( Pt 1)():95-102.
1998: Mendelson I; Kronman C; Ariel N; Shafferman A; Velan B
Bovine acetylcholinesterase: cloning, expression and characterization.
The Biochemical journal 1998;334 ( Pt 1)():251-9.
1998: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Functional characteristics of the oxyanion hole in human acetylcholinesterase.
The Journal of biological chemistry 1998;273(31):19509-17.
1997: Shafferman A; Ordentlich A; Barak D; Stein D; Ariel N; Velan B
Aging of somanyl-acetylcholinesterase adducts: facts and models.
The Biochemical journal 1997;324 ( Pt 3)():996-8.
1997: Barak R; Ordentlich A; Barak D; Fischer M; Benschop H P; De Jong L P; Segall Y; Velan B; Shafferman A
Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry.
FEBS letters 1997;407(3):347-52.
1996: Velan B; Barak D; Ariel N; Leitner M; Bino T; Ordentlich A; Shafferman A
Structural modifications of the omega loop in human acetylcholinesterase.
FEBS letters 1996;395(1):22-8.
1996: Shafferman A; Ordentlich A; Barak D; Stein D; Ariel N; Velan B
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.
The Biochemical journal 1996;318 ( Pt 3)():833-40.
1996: Grosfeld H; Barak D; Ordentlich A; Velan B; Shafferman A
Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.
Molecular pharmacology 1996;50(3):639-49.
1996: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
The Journal of biological chemistry 1996;271(20):11953-62.
1996: Flashner Y; Schlomai J; Shafferman A
Three novel plasmid R6K proteins act in concert to distort DNA within the alpha and beta origins of DNA replication.
Molecular microbiology 1996;19(5):985-96.
1996: Shafferman A; Lustig S; Inbar Y; Halevy M; Schneider P; Bino T; Leitner M; Grosfeld H; Velan B; Schödel F; Cohen S
Alphavirus hybrid virion vaccines.
Advances in experimental medicine and biology 1996;397():41-7.
1995: Urh M; Flashner Y; Shafferman A; Filutowicz M
Altered (copy-up) forms of initiator protein pi suppress the point mutations inactivating the gamma origin of plasmid R6K.
Journal of bacteriology 1995;177(23):6732-9.
1995: Barak D; Ordentlich A; Bromberg A; Kronman C; Marcus D; Lazar A; Ariel N; Velan B; Shafferman A
Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.
Biochemistry 1995;34(47):15444-52.
1995: Kronman C; Velan B; Marcus D; Ordentlich A; Reuveny S; Shafferman A
Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.
The Biochemical journal 1995;311 ( Pt 3)():959-67.
1995: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
The Journal of biological chemistry 1995;270(5):2082-91.
1994: Kronman C; Ordentlich A; Barak D; Velan B; Shafferman A
The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.
The Journal of biological chemistry 1994;269(45):27819-22.
1994: Velan B; Kronman C; Flashner Y; Shafferman A
Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase.
The Journal of biological chemistry 1994;269(36):22719-25.
1994: Shafferman A; Ordentlich A; Barak D; Kronman C; Ber R; Bino T; Ariel N; Osman R; Velan B
Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.
The EMBO journal 1994;13(15):3448-55.
1994: Ashani Y; Grunwald J; Kronman C; Velan B; Shafferman A
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Molecular pharmacology 1994;45(3):555-60.
1994: Barak D; Kronman C; Ordentlich A; Ariel N; Bromberg A; Marcus D; Lazar A; Velan B; Shafferman A
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
The Journal of biological chemistry 1994;269(9):6296-305.
1993: Velan B; Kronman C; Ordentlich A; Flashner Y; Leitner M; Cohen S; Shafferman A
N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
The Biochemical journal 1993;296 ( Pt 3)():649-56.
1993: Ordentlich A; Kronman C; Barak D; Stein D; Ariel N; Marcus D; Velan B; Shafferman A
Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
FEBS letters 1993;334(2):215-20.
1993: Lewis M G; Elkins W R; McCutchan F E; Benveniste R E; Lai C Y; Montefiori D C; Burke D S; Eddy G A; Shafferman A
Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.
Vaccine 1993;11(13):1347-55.
1993: Alving C R; Detrick B; Richards R L; Lewis M G; Shafferman A; Eddy G A
Novel adjuvant strategies for experimental malaria and AIDS vaccines.
Annals of the New York Academy of Sciences 1993;690():265-75.
1993: Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
The Journal of biological chemistry 1993;268(23):17083-95.
1993: Kerem A; Kronman C; Bar-Nun S; Shafferman A; Velan B
Interrelations between assembly and secretion of recombinant human acetylcholinesterase.
The Journal of biological chemistry 1993;268(1):180-4.
1993: Shafferman A; Lewis M G; McCutchan F E; Benveniste R E; Jahrling P B; Burke D S; Eddy G A
Prevention of transmission of simian immunodeficiency virus from vaccinated macaques that developed transient virus infection following challenge.
Vaccine 1993;11(8):848-52.
1992: Shafferman A; Velan B; Ordentlich A; Kronman C; Grosfeld H; Leitner M; Flashner Y; Cohen S; Barak D; Ariel N
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
The EMBO journal 1992;11(10):3561-8.
1992: Shafferman A; Kronman C; Flashner Y; Leitner M; Grosfeld H; Ordentlich A; Gozes Y; Cohen S; Ariel N; Barak D
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
The Journal of biological chemistry 1992;267(25):17640-8.
1992: Shafferman A; Lewis M G; McCutchan F E; Benveniste R E; Jahrling P B; Hickman R L; Lai C Y; Burke D S; Eddy G A
Vaccination of macaques with SIV conserved envelope peptides suppressed infection and prevented disease progression and transmission.
AIDS research and human retroviruses 1992;8(8):1483-7.
1992: Rosenberg Y J; Shafferman A; White B D; Papermaster S F; Leon E; Eddy G A; Benveniste R; Burke D S; Lewis M G
Variation in the CD4+ and CD8+ populations in lymph nodes does not reflect that in the blood during SIVMNE/E11S infection of macaques.
Journal of medical primatology 1992;21(2-3):131-7.
1992: Grosfeld H; Lustig S; Gozes Y; Velan B; Cohen S; Leitner M; Lachmi B; Katz D; Olshevski U; Shafferman A
Divergent envelope E2 alphavirus sequences spanning amino acids 297 to 352 induce in mice virus-specific protective immunity and antibodies with complement-mediated cytolytic activity.
Journal of virology 1992;66(2):1084-90.
1991: Velan B; Grosfeld H; Kronman C; Leitner M; Gozes Y; Lazar A; Flashner Y; Marcus D; Cohen S; Shafferman A
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.
The Journal of biological chemistry 1991;266(35):23977-84.
1991: Shafferman A; Jahrling P B; Benveniste R E; Lewis M G; Phipps T J; Eden-McCutchan F; Sadoff J; Eddy G A; Burke D S
Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7126-30.
1991: Grosfeld H; Velan B; Leitner M; Lustig S; Lachi B E; Cohen S; Shafferman A
Delineation of protective epitopes on the E2-envelope glycoprotein of Semliki Forest virus.
Vaccine 1991;9(6):451-6.
1990: Flashner Y; Shafferman A
Alpha and beta replication origins of plasmid R6K show similar distortions of the DNA helix in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9123-7.
1989: Grosfeld H; Velan B; Leitner M; Cohen S; Lustig S; Lachmi B E; Shafferman A
Semliki Forest virus E2 envelope epitopes induce a nonneutralizing humoral response which protects mice against lethal challenge.
Journal of virology 1989;63(8):3416-22.
1989: Schwers A; Severin J E; Bublot M; Maenhoudt M; Pastoret P P; Vanden Broecke C; Zilimwabagabo P; Velan B; Cohen S; Shafferman A
Protection of cattle from infection with vaccinia virus by bovine interferon alpha C.
The Veterinary record 1989;125(1):15-6.
1989: Shafferman A; Layne A; Sadoff J; Burke D S; Morton W R; Benveniste R E
Antibody recognition of SIVmac envelope peptides in plasma from macaques experimentally infected with SIV/Mne.
AIDS research and human retroviruses 1989;5(3):327-36.
1989: Kobiler D; Grosfeld H; Leitner M; Monzain R; Frist C; Seri T; Cohen S; Velan B; Shafferman A; Gozes Y
Production of monoclonal antibodies toward bovine interferons-alpha suitable for immunopurification.
Journal of interferon research 1989;9(2):189-93.
1989: Shafferman A; Lennox J; Grosfeld H; Sadoff J; Redfield R R; Burke D S
Patterns of antibody recognition of selected conserved amino acid sequences from the HIV envelope in sera from different stages of HIV infection.
AIDS research and human retroviruses 1989;5(1):33-9.
1987: Shafferman A; Flashner Y; Hertman I; Olami Y; Cohen S
Molecular aspects of genetic instability of an artificial 68 bp perfect palindrome in Escherichia coli.
Molecular & general genetics : MGG 1987;208(1-2):294-300.
1987: Shafferman A; Flashner Y; Hertman I; Lion M
Identification and characterization of the functional alpha origin of DNA replication of the R6K plasmid and its relatedness to the R6K beta and gamma origins.
Molecular & general genetics : MGG 1987;208(1-2):263-70.
1987: Shafferman A; Velan B; Cohen S; Leitner M; Grosfeld H
Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects.
The Journal of biological chemistry 1987;262(13):6227-37.
1986: Cohen S; Velan B; Bino T; Rosenberg H; Shafferman A
Induction and characterization of bovine leukocyte interferon.
Methods in enzymology 1986;119():136-44.
1986: Velan B; Cohen S; Grosfeld H; Shafferman A
Isolation of bovine IFN-alpha genes and their expression in bacteria.
Methods in enzymology 1986;119():464-74.
1985: Velan B; Cohen S; Grosfeld H; Leitner M; Shafferman A
Bovine interferon alpha genes. Structure and expression.
The Journal of biological chemistry 1985;260(9):5498-504.
1985: Grosfeld H; Cohen S; Velan B; Shafferman A
Genetic engineering of human interferons from lymphoblastoid cells: III. Purification, physicochemical and biological properties of bacterial IFN-alpha J1.
Advances in biotechnological processes 1985;4():59-78.
1985: Shafferman A; Cohen S; Grosfeld H; Leitner M; Velan B
Genetic engineering of human interferons from lymphoblastoid cells: II. Construction of trp expression plasmids and their use for efficient expression of IFN-alpha J1.
Advances in biotechnological processes 1985;4():25-57.
1985: Velan B; Cohen S; Grosfeld H; Shalita Z; Shafferman A
Cloning of a bovine interferon-alpha gene subfamily and comparisons between genetically engineered and leukocyte bovine interferons.
Developments in biological standardization 1985;60():355-69.
1985: Cohen S; Velan B; Shafferman A
Genetic engineering of human interferons from lymphoblastoid cells: I. Cloning of interferon species expressed in Sendai-induced Namalva cells.
Advances in biotechnological processes 1985;4():1-23.
1985: Cohen S; Velan B; Grosfeld H; Shalita Z; Leitner M; Shafferman A
Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells.
Developments in biological standardization 1985;60():111-22.
1985: Shafferman A; Flashner Y; Hertman I; Rein R
DNA repair in the in vivo site specific excision of palindromic sequences.
Progress in clinical and biological research 1985;172A():19-36.
1984: Grosfeld H; Cohen S; Velan B; Shalita Z; Shafferman A
Mutations not altering the symmetrical sequences in the trp operator yield a constitutive phenotype.
Molecular & general genetics : MGG 1984;195(1-2):358-60.
1983: Shafferman A; Flashner Y; Hertman I
Genetic instability of an artificial palindrom DNA sequence.
Journal of biomolecular structure & dynamics 1983;1(3):729-42.

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