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Ajay Shah

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Husain Shabeeh; Barbara Casadei; Phil Chowienczyk; Rafal Dworakowski; Narbeh Melikian; Ajay M Shah
Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload.
Husain Shabeeh; Ajay M Shah; Sally Brett; Barbara Casadei; Narbeh Melikian; Michael Seddon; Phil Chowienczyk
Sympathetic activation increases NO release from eNOS but neither eNOS nor nNOS play an essential role in exercise hyperemia in the human forearm.
Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.

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All Publications

2013: Husain Shabeeh; Barbara Casadei; Phil Chowienczyk; Rafal Dworakowski; Narbeh Melikian; Ajay M Shah
Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload.
American journal of physiology. Heart and circulatory physiology 2013;304(9):H1277-82.
2013: Husain Shabeeh; Ajay M Shah; Sally Brett; Barbara Casadei; Narbeh Melikian; Michael Seddon; Phil Chowienczyk
Sympathetic activation increases NO release from eNOS but neither eNOS nor nNOS play an essential role in exercise hyperemia in the human forearm.
American journal of physiology. Heart and circulatory physiology 2013;304(9):H1225-30.
2013: Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
The Journal of biological chemistry 2013;288(14):10176-87.
2013: Emre Ozkumur; Sudarshana Sengupta; Lecia V Sequist; Ajay M Shah; Alice T Shaw; Kyle Smith; Philipp S Spuhler; Shannon L Stott; James P Sullivan; David T Ting; Julie Trautwein; John R Walsh; Min Yu; Thomas A Barber; Aditya Bardia; Elena Brachtel; Pin-i Chen; Jordan C Ciciliano; Benjamin L Emmink; Daniel A Haber; Ravi Kapur; Nezihi Murat Karabacak; Anya Kimura; Richard J Lee; David N Louis; Xi Luo; Shyamala Maheswaran; David T Miyamoto; Bailey Morgan; Mehmet Toner
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.
Science translational medicine 2013;5(179):179ra47.
2013: Narayana Anilkumar; Alison C Brewer; Gorka San Jose; Claire Sand; Celio X C Santos; Iain Sawyer; Derek Warren; Ajay M Shah
A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):e104-12.
2013: David A Kass; Ajay M Shah
Redox and nitrosative regulation of cardiac remodeling.
Antioxidants & redox signaling 2013;18(9):1021-3.
2013: Min Zhang; Alessandra Ghigo; Emilio Hirsch; Alessia Perino; Ajay M Shah
NADPH oxidases in heart failure: poachers or gamekeepers?
Antioxidants & redox signaling 2013;18(9):1024-41.
2013: Min Yu; Aditya Bardia; Jose Baselga; Elena F Brachtel; Jordan C Ciciliano; Kyle F Concannon; Maria C Donaldson; Daniel A Haber; Steven J Isakoff; Sridhar Ramaswamy; Lecia V Sequist; Dennis Sgroi; Ajay M Shah; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Marissa N Wells; Ben S Wittner; Shyamala Maheswaran
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Science (New York, N.Y.) 2013;339(6119):580-4.
2013: Xiaoke Yin; Ignat Drozdov; Joseph Dwyer; Lindsay M Edwards; John Griffiths; Sarah R Langley; Basetti Madhu; Ursula Mayr; Adam Nabeebaccus; Ajay M Shah; Qiuru Xing; Manuel Mayr
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.
Journal of molecular and cellular cardiology 2013;55():27-30.
2013: Joseph R Burgoyne; Heloise Mongue Din; Philip Eaton; Ajay M Shah
Response to "Detailed aspects of redox signaling in cardiac physiology and pathology".
Circulation research 2013;112(1):e2.
2013: Sanjay Chaubey; Gareth E Jones; Ajay M Shah; Alison C Cave; claire wells
Nox2 is required for macrophage chemotaxis towards CSF-1.
PloS one 2013;8(2):e54869.
2012: Alkystis Phinikaridou; Ajay M Shah; Marcelo E Andia; René M Botnar
Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology.
American journal of physiology. Heart and circulatory physiology 2012;303(12):H1397-410.
2012: Sanjay Chaubey; Ian Judson; Habib Khan; Mark Monaghan; Ajay M Shah; Charlotte Benson; Olaf Wendler
Six-year survival of a patient with pulmonary artery angiosarcoma.
Asian cardiovascular & thoracic annals 2012;20(6):728-30.
2012: Rafal Dworakowski; Emma Alcock; Amit Bhan; Beth Brickham; Jonathan Byrne; TK Dew; Mark J Monaghan; Peter Pearson; Kailasam Rajagopal; Ajay M Shah; Roy Sherwood; Lindsay Smith; Olaf Wendler; Philip A MacCarthy
Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction.
Heart (British Cardiac Society) 2012;98(22):1641-6.
2012: Joseph R Burgoyne; Philip Eaton; Héloïse Mongue-Din; Ajay M Shah
Redox signaling in cardiac physiology and pathology.
Circulation research 2012;111(8):1091-106.
2012: Manling Zhang; Djahida Bedja; Philip Eaton; Steven Hsu; Aiyang Jiang; Dong-ik Lee; Takahiro Nagayama; Taishi Nakamura; Celio X C Santos; Ajay M Shah; Eiki Takimoto; Yuan Yuan; David A Kass
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.
Circulation 2012;126(8):942-51.
2012: Andrea Babelova; Janet Beckmann; Narayana Anilkumar; Despina Avaniadi; Christian Fork; Oliver Jung; Judith Kosowski; Liliana Schaefer; Katrin Schröder; Ajay M Shah; Norbert Weissmann; Ralf P Brandes
Role of Nox4 in murine models of kidney disease.
Free radical biology & medicine 2012;53(4):842-53.
2012: Andrea Protti; René M Botnar; Xuebin Dong; Alexander Sirker; Ajay M Shah
MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2012;303(3):H309-14.
2012: Wiebke Kallenborn-Gerhardt; Judith Kosowski; Katharina Kynast; Ruirui Lu; Ellen Niederberger; Ralf P Brandes; Domenico Del Turco; Gerd Geisslinger; Katrin Schröder; Ajay M Shah; Achim Schmidtko
NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(30):10136-45.
2012: Katrin Schröder; Ajay M Shah; Norbert Weissmann; Min Zhang; Stefanie Dimmeler; Judith Kosowski; Christoph Kruse; Peter Luedike; U Ruth Michaelis; Anja Mieth; Rainer Pliquett; Sebastian Benkhoff; Ralf P Brandes
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.
Circulation research 2012;110(9):1217-25.
2012: Ajay M Shah; Shannon L Stott; Matthew Ulman; Min Yu; Jordan Ciciliano; Daniel A Haber; Kenneth Kotz; Shyamala Maheswaran; Zev Nakamura; Mehmet Toner
Biopolymer system for cell recovery from microfluidic cell capture devices.
Analytical chemistry 2012;84(8):3682-8.
2012: Adil Rajwani; Jaswinder K Sethi; Ajay M Shah; Jessica Smith; Piruthivi Sukumar; antonio vidal-puig; Hema Viswambharan; Afroze Abbas; Amir Aziz; Richard M Cubbon; Edward R Duncan; Vivienne Ezzat; Matthew Gage; Peter J Grant; Helen Imrie; Matthew B Kahn; Mark T Kearney; Karen E Porter; Shouhong Xuan; Nadira Y Yuldasheva; Stephen B Wheatcroft
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.
Diabetes 2012;61(4):915-24.
2012: Javier Barallobre-Barreiro; ATHANASIOS DIDANGELOS; Nieves Doménech; Ignat Drozdov; Mariana Fernández-Caggiano; Valentina O Puntmann; Friedrich A Schoendube; Ajay M Shah; Peter Willeit; Xiaoke Yin; Guillermo Aldama-López; Manuel Mayr
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.
Circulation 2012;125(6):789-802.
2012: Shazia T Hussain; Masaki Ishida; Philip A MacCarthy; Michael S Marber; Gerry P McCann; Geraint Morton; Matthias Paul; Divaka Perera; Sven Plein; Simon Redwood; Andreas Schuster; Ajay M Shah; Mark A Westwood; Amedeo Chiribiri; Eike Nagel
Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2012;14():65.
2012: Norbert Weissmann; Michael Mederos y Schnitzler; Ralf P Brandes; Alison C Brewer; Marc Freichel; Beate Fuchs; Hossein A Ghofrani; Friedrich Grimminger; Thomas Gudermann; Hermann Kalwa; Karl-Heinz Krause; Marcel Meissner; Stefan Offermanns; Oleg Pak; Ralph Theo Schermuly; Harald H H W Schmidt; Werner Seeger; Ajay M Shah; Ursula Storch; Akylbek Sydykov; Florian Veit; Alexander Dietrich
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Nature communications 2012;3():649.
2011: Alexander Sirker; Min Zhang; Ajay M Shah
NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies.
Basic research in cardiology 2011;106(5):735-47.
2011: Ajay M Shah; Douglas L Mann
In search of new therapeutic targets and strategies for heart failure: recent advances in basic science.
Lancet 2011;378(9792):704-12.
2011: Richard M Cubbon; Anthony C Fisher; Keith A A Fox; Chris Gale; David Groves; Matthew B Kahn; Lorraine C Kearney; SJ Lindsay; Jim Nolan; Adil Rajwani; Robert J Sapsford; Clyde Schechter; Ajay M Shah; Stephen B Wheatcroft; Klaus K A Witte; Azfar G Zaman; Wazir Baig; Pauline Barlow; Philip D Batin; W Paul Brooksby; Jon A Byrne; Mark T Kearney
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.
Circulation. Heart failure 2011;4(4):396-403.
2011: Alison C Brewer; Thomas V A Murray; Matthew Arno; Min Zhang; Narayana P Anilkumar; Giovanni E Mann; Ajay M Shah
Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.
Free radical biology & medicine 2011;51(1):205-15.
2011: Partheeban Karuppasamy; Sanjay Chaubey; TK Dew; Rebecca Musto; Roy Sherwood; Jatin Desai; Lindsay John; Ajay M Shah; Michael S Marber; Gudrun Kunst
Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation?
Basic research in cardiology 2011;106(4):511-9.
2011: Colin E Murdoch; Sara P Alom-Ruiz; Minshu Wang; Min Zhang; Simon Walker; Bin Yu; Alison Brewer; Ajay M Shah
Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction.
Basic research in cardiology 2011;106(4):527-38.
2011: Robin Ray; Colin E Murdoch; Minshu Wang; Celio X Santos; Min Zhang; Sara Alom-Ruiz; Narayana Anilkumar; Alexandre Ouattara; Alison C Cave; Simon J Walker; David J Grieve; Rebecca L Charles; Philip Eaton; Alison C Brewer; Ajay M Shah
Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(6):1368-76.
2011: Ina Takac; Katrin Schröder; Leilei Zhang; Bernard Lardy; Narayana Anilkumar; J David Lambeth; Ajay M Shah; Francoise Morel; Ralf P Brandes
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4.
The Journal of biological chemistry 2011;286(15):13304-13.
2011: Celio X C Santos; Narayana Anilkumar; Min Zhang; Alison C Brewer; Ajay M Shah
Redox signaling in cardiac myocytes.
Free radical biology & medicine 2011;50(7):777-93.
2011: Netanya Y Spencer; Ziying Yan; Ryan L Boudreau; Yulong Zhang; Meihui Luo; Qiang Li; Xin Tian; Ajay M Shah; Robin L Davisson; Beverly Davidson; Botond Banfi; John F Engelhardt
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.
The Journal of biological chemistry 2011;286(11):8977-87.
2011: Beatriz S Stolf; Alcione Vendramin; Ioannis Smyrnias; Ajay M Shah; Hiro Goto; Francisco R M Laurindo; Lucia Rossetti Lopes; CX Santos
Protein disulfide isomerase and host-pathogen interaction.
TheScientificWorldJournal 2011;11():1749-61.
2011: Ignat Drozdov; Christos Ouzounis; Ajay M Shah; Sophia Tsoka
Functional Genomics Assistant (FUGA): a toolbox for the analysis of complex biological networks.
BMC research notes 2011;4():462.
2011: Thomas Eschenhagen; Thomas Force; Michael S Ewer; Gilles W De Keulenaer; Thomas M Suter; Stefan D Anker; Metin Avkiran; Evandro de Azambuja; Jean-Luc Balligand; Dirk L Brutsaert; Gianluigi Condorelli; Arne Hansen; Stephane Heymans; Joseph A Hill; Emilio Hirsch; Denise Hilfiker-Kleiner; Stefan Janssens; Steven de Jong; Gitte Neubauer; Burkert Pieske; Piotr Ponikowski; Munir Pirmohamed; Mathias Rauchhaus; Douglas Sawyer; Peter H Sugden; Johann Wojta; Faiez Zannad; Ajay M Shah
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.
European journal of heart failure 2011;13(1):1-10.
2011: Adam Nabeebaccus; Min Zhang; Ajay M Shah
NADPH oxidases and cardiac remodelling.
Heart failure reviews 2011;16(1):5-12.
2010: Youyou Zhao; Declan McLaughlin; Emma Robinson; Adam P Harvey; Michelle B Hookham; Ajay M Shah; Barbara J McDermott; David J Grieve
Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy.
Cancer research 2010;70(22):9287-97.
2010: Shannon L Stott; Chia-Hsien Hsu; Dina Tsukrov; Min Yu; David T Miyamoto; Belinda A Waltman; S Michael Rothenberg; Ajay M Shah; Malgorzata E Smas; George K Korir; Frederick P Floyd; Anna J Gilman; Jenna B Lord; Daniel Winokur; Simeon Springer; daniel irimia; Sunitha Nagrath; Lecia V Sequist; Richard J Lee; Kurt J Isselbacher; Shyamala Maheswaran; Daniel A Haber; Mehmet Toner
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18392-7.
2010: Min Zhang; Alison C Brewer; Katrin Schröder; Celio X C Santos; David J Grieve; Minshu Wang; Narayana Anilkumar; Bin Yu; Xuebin Dong; Simon J Walker; Ralf P Brandes; Ajay M Shah
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18121-6.
2010: Andrea Protti; Alexander Sirker; Ajay M Shah; René M Botnar
Late gadolinium enhancement of acute myocardial infarction in mice at 7T: cine-FLASH versus inversion recovery.
Journal of magnetic resonance imaging : JMRI 2010;32(4):878-86.
2010: Wenbin Liang; Gavin Y Oudit; Mikin M Patel; Ajay M Shah; James R Woodgett; Robert G Tsushima; Michael E Ward; Peter H Backx
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.
Hypertension 2010;56(3):422-9.
2010: Sven Wind; Knut Beuerlein; Melanie E Armitage; Ashraf Taye; Arun H S Kumar; Daniel Janowitz; Christina Neff; Ajay M Shah; Kirstin Wingler; Harald Schmidt
Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition.
Hypertension 2010;56(3):490-7.
2010: Ian G Webb; Yasuhiro Nishino; James E Clark; Colin Murdoch; Simon J Walker; Marcus R Makowski; Rene M Botnar; Simon R Redwood; Ajay M Shah; Michael S Marber
Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.
Cardiovascular research 2010;87(3):494-503.
2010: Rudolf A de Boer; Ajay M Shah; Herman H W Silljé
Meeting highlights from the 2010 European society of cardiology heart failure association winter meeting: translational heart failure research.
European journal of heart failure 2010;12(5):417-9.
2010: Mingyi Wang; Jing Zhang; Simon J Walker; Rafal Dworakowski; Edward G Lakatta; Ajay M Shah
Involvement of NADPH oxidase in age-associated cardiac remodeling.
Journal of molecular and cellular cardiology 2010;48(4):765-72.
2010: Ignat Drozdov; Sophia Tsoka; Christos Ouzounis; Ajay M Shah
Genome-wide expression patterns in physiological cardiac hypertrophy.
BMC genomics 2010;11():557.
2010: Christoph Kleinschnitz; Henrike Grund; Kirstin Wingler; Melanie E Armitage; Emma Jones; Manish Mittal; David Barit; Tobias Schwarz; Christian Geis; Peter Kraft; Konstanze Barthel; Michael K Schuhmann; Alexander M Herrmann; Sven G Meuth; Guido Stoll; Sabine Meurer; Anja Schrewe; Lore Becker; Valérie Gailus-Durner; Helmut Fuchs; Thomas Klopstock; Martin Hrabé De Angelis; Karin Jandeleit-Dahm; Ajay M Shah; Norbert Weissmann; Harald Schmidt
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
PLoS biology 2010;8(9):.
2009: Narbeh Melikian; Michael D Seddon; Barbara Casadei; Philip J Chowienczyk; Ajay M Shah
Neuronal nitric oxide synthase and human vascular regulation.
Trends in cardiovascular medicine 2009;19(8):256-62.
2009: Ashwin Akki; Min Zhang; Colin Murdoch; Alison Brewer; Ajay M Shah
NADPH oxidase signaling and cardiac myocyte function.
Journal of molecular and cellular cardiology 2009;47(1):15-22.
2009: Alison C Brewer; Ajay M Shah
Redox signalling and miRNA function in cardiomyocytes.
Journal of molecular and cellular cardiology 2009;47(1):2-4.
2009: Adrienn Kis; Colin Murdoch; Min Zhang; Anjana Siva; Sergio Rodriguez-Cuenca; stefania carobbio; Agnes Lukasik; Margaret Blount; Steve O'Rahilly; Sarah L Gray; Ajay M Shah; antonio vidal-puig
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.
European journal of heart failure 2009;11(6):533-41.
2009: Michael Seddon; Narbeh Melikian; Rafal Dworakowski; Husain Shabeeh; Benyu Jiang; Jonathan Byrne; Barbara Casadei; Philip J Chowienczyk; Ajay M Shah
Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.
Circulation 2009;119(20):2656-62.
2009: Melanie Marshall; Narayana Anilkumar; Joanne Layland; Simon J Walker; Jonathan C Kentish; Ajay M Shah; Alison C Cave
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Cardiovascular research 2009;82(1):67-76.
2009: Stephane Heymans; Emilio Hirsch; Stefan D Anker; Pal Aukrust; Jean-Luc Balligand; Jan Willem Cohen-Tervaert; Helmut Drexler; Gerasimos Filippatos; Stephan B Felix; Lars Gullestad; Denise Hilfiker-Kleiner; Stefan Janssens; Roberto Latini; Gitte Neubauer; Walter J Paulus; Burkert Pieske; Piotr Ponikowski; Blanche Schroen; Heinz-Peter Schultheiss; Carsten Tschöpe; Marc van Bilsen; Faiez Zannad; John McMurray; Ajay M Shah
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
European journal of heart failure 2009;11(2):119-29.
2009: Narayana Anilkumar; Alexander Sirker; Ajay M Shah
Redox sensitive signaling pathways in cardiac remodeling, hypertrophy and failure.
Frontiers in bioscience : a journal and virtual library 2009;14():3168-87.
2008: Edward R Duncan; Paul A Crossey; Simon Walker; Narayana Anilkumar; Lucilla Poston; Gillian Douglas; Vivienne A Ezzat; Stephen B Wheatcroft; Ajay M Shah; Mark T Kearney; Mark I Kearney
Effect of endothelium-specific insulin resistance on endothelial function in vivo.
Diabetes 2008;57(12):3307-14.
2008: Li Zhang; Olivia R Sheppard; Ajay M Shah; Alison C Brewer
Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F.
Free radical biology & medicine 2008;45(5):679-85.
2008: Yasuhiro Nishino; Ian G Webb; Sean Davidson; Aminul I Ahmed; James E Clark; Sebastien Jacquet; Ajay M Shah; Tetsuji Miura; Derek M Yellon; Metin Avkiran; Michael S Marber
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.
Circulation research 2008;103(3):307-14.
2008: Narayana Anilkumar; Roberta Weber; Min Zhang; Alison Brewer; Ajay M Shah
Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1347-54.
2008: Xavier LOYER; Ana Gomez; Paul Milliez; Maria Fernandez-Velasco; Peter Vangheluwe; Laurent Vinet; Dominique Charue; Emilie Vaudin; Wei Zhang; Yannis Sainte-Marie; Estelle Robidel; Isabelle Marty; Bernd Mayer; Frédéric Jaisser; Jean-Jacques Mercadier; Sylvain Richard; Ajay M Shah; Jean-Pierre Benitah; Jane-Lise Samuel; Christophe Heymes
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Circulation 2008;117(25):3187-98.
2008: Sara P Alom-Ruiz; Narayana Anilkumar; Ajay M Shah
Reactive oxygen species and endothelial activation.
Antioxidants & redox signaling 2008;10(6):1089-100.
2008: Greta J Sawyer; Aidan Grehan; Xuebin Dong; Michael Whitehorne; Michael Seddon; Ajay M Shah; Xiaohong Zhang; Siamak Salehi; John W Fabre
Low-volume hydrodynamic gene delivery to the rat liver via an isolated segment of the inferior vena cava: efficiency, cardiovascular response and intrahepatic vascular dynamics.
The journal of gene medicine 2008;10(5):540-50.
2008: Michael D Seddon; Philip J Chowienczyk; Sally E Brett; Barbara Casadei; Ajay M Shah
Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo.
Circulation 2008;117(15):1991-6.
2008: Rafal Dworakowski; Simon Walker; Aziz Momin; Jatin Desai; Ahmed El-Gamel; Olaf Wendler; Mark T Kearney; Ajay M Shah
Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure.
Journal of the American College of Cardiology 2008;51(14):1349-56.
2008: Anna Starr; Rabea Graepel; Julie Keeble; Sabine Schmidhuber; Natalie Clark; Andrew Grant; Ajay M Shah; Susan D Brain
A reactive oxygen species-mediated component in neurogenic vasodilatation.
Cardiovascular research 2008;78(1):139-47.
2008: John W Fabre; A Grehan; M Whitehorne; Greta J Sawyer; Xuebin Dong; S Salehi; L Eckley; Xiaohong Zhang; M Seddon; Ajay M Shah; M Davenport; M Rela
Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava.
Gene therapy 2008;15(6):452-62.
2008: Narbeh Melikian; Philip J Chowienczyk; Philip A MacCarthy; Ian L Williams; Stephen B Wheatcroft; Roy Sherwood; Christopher Gale; Ajay M Shah; Mark T Kearney
Determinants of endothelial function in asymptomatic subjects with and without the metabolic syndrome.
Atherosclerosis 2008;197(1):375-82.
2008: Alexander Alexandrovich; Ali Qureishi; Amélie E Coudert; Li Zhang; Agamemnon E Grigoriadis; Ajay M Shah; Alison C Brewer; John Pizzey
A role for GATA-6 in vertebrate chondrogenesis.
Developmental biology 2008;314(2):457-70.
2008: Yee H Looi; David J Grieve; Anjana Siva; Simon J Walker; Narayana Anilkumar; Alison C Cave; Michael S Marber; Mark J Monaghan; Ajay M Shah
Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction.
Hypertension 2008;51(2):319-25.
2008: Rafal Dworakowski; Sara P Alom-Ruiz; Ajay M Shah
NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.
Pharmacological reports : PR 2008;60(1):21-8.
2007: Edward R Duncan; Simon J Walker; Vivienne A Ezzat; Stephen B Wheatcroft; Jian-Mei Li; Ajay M Shah; Mark T Kearney
Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1311-9.
2007: Narbeh Melikian; Mark T Kearney; Martyn R Thomas; Bernard De Bruyne; Ajay M Shah; Philip A MacCarthy
A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve.
European heart journal 2007;28(18):2188-94.
2007: Aziz U Momin; Narbeh Melikian; Stephen B Wheatcroft; David J Grieve; Lindsay C John; Ahmed El-Gamel; Michael T Marrinan; Jatin B Desai; Catherine Driver; Roy Sherwood; Ajay M Shah; Mark T Kearney
The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery.
The Journal of thoracic and cardiovascular surgery 2007;134(2):335-41.
2007: Mike Seddon; Yee H Looi; Ajay M Shah
Oxidative stress and redox signalling in cardiac hypertrophy and heart failure.
Heart (British Cardiac Society) 2007;93(8):903-7.
2007: Mike Seddon; Ajay M Shah; Barbara Casadei
Cardiomyocytes as effectors of nitric oxide signalling.
Cardiovascular research 2007;75(2):315-26.
2007: Damien bARRAUD; Valérie Faivre; Thibaud Damy; Stéphane Welschbillig; Etienne Gayat; Christophe Heymes; Didier Payen; Ajay M Shah; Alexandre Mebazaa
Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone.
Critical care medicine 2007;35(5):1376-82.
2007: Narbeh Melikian; Stephen B Wheatcroft; Okechukwu Samuel Ogah; Cliona Murphy; Philip J Chowienczyk; Anthony S Wierzbicki; Thomas Sanders; Benyu Jiang; Edward R Duncan; Ajay M Shah; Mark T Kearney
Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.
Hypertension 2007;49(4):873-7.
2007: Cliona Murphy; Gajen S Kanaganayagam; Benyu Jiang; Philip J Chowienczyk; Rainer Zbinden; Mrinal Saha; Salman Rahman; Ajay M Shah; Michael S Marber; Mark T Kearney
Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):936-42.
2007: Min Zhang; Ajay M Shah
Role of reactive oxygen species in myocardial remodeling.
Current heart failure reports 2007;4(1):26-30.
2007: Stephen B Wheatcroft; Mark T Kearney; Ajay M Shah; Vivienne A Ezzat; John R Miell; Michel Modo; Stephen C R Williams; Will P Cawthorn; Gema Medina-Gomez; Antonio Vidal-Puig; Jaswinder Sethi; Paul A Crossey
IGF-binding protein-2 protects against the development of obesity and insulin resistance.
Diabetes 2007;56(2):285-94.
2007: Alexander Sirker; Min Zhang; Colin E Murdoch; Ajay M Shah
Involvement of NADPH oxidases in cardiac remodelling and heart failure.
American journal of nephrology 2007;27(6):649-60.
2006: Aziz U Momin; Narbeh Melikian; Ajay M Shah; David J Grieve; Stephen B Wheatcroft; Lindsay John; Ahmed El-Gamel; Jatin B Desai; Toby Nelson; Catherine Driver; Roy A Sherwood; Mark T Kearney
Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance.
European heart journal 2006;27(19):2294-9.
2006: Téni G Ebrahimian; Christophe Heymes; Dong You; Olivier Blanc-Brude; Barend Mees; Ludovic Waeckel; Micheline Duriez; José Vilar; Ralph P Brandes; Bernard I Levy; Ajay M Shah; Jean-Sébastien Silvestre
NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes.
The American journal of pathology 2006;169(2):719-28.
2006: Mohamed Bellahcene; Sebastien Jacquet; Xue B Cao; Masaya Tanno; Robert S Haworth; Joanne Layland; Alamgir M N Kabir; Matthias Gaestel; Roger J Davis; Richard A Flavell; Ajay M Shah; Metin Avkiran; Michael S Marber
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.
Journal of the American College of Cardiology 2006;48(3):545-55.
2006: Ajay M Shah; Heinrich Sauer
Transmitting biological information using oxygen: reactive oxygen species as signalling molecules in cardiovascular pathophysiology.
Cardiovascular research 2006;71(2):191-4.
2006: Colin E Murdoch; Min Zhang; Alison C Cave; Ajay M Shah
NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure.
Cardiovascular research 2006;71(2):208-15.
2006: Sofian Johar; Alison C Cave; Anilkumar Narayanapanicker; David J Grieve; Ajay M Shah
Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1546-8.
2006: Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet Patel; Roy A Sherwood; Ajay M Shah; Mark T Kearney
Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2006;3(1):34-8.
2006: Alison C Cave; Alison C Brewer; Anilkumar Narayanapanicker; Robin Ray; David J Grieve; Simon Walker; Ajay M Shah
NADPH oxidases in cardiovascular health and disease.
Antioxidants & redox signaling 2006;8(5-6):691-728.
2006: Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; A Patel; Roy Sherwood; Aziz U Momin; Ajay M Shah; M T Kearney
Effect of fat distribution on endothelial-dependent and endothelial-independent vasodilatation in healthy humans.
Diabetes, obesity & metabolism 2006;8(3):296-301.
2006: Alexander Alexandrovich; Matthew Arno; Roger Patient; Ajay M Shah; John Pizzey; Alison C Brewer
Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.
Mechanisms of development 2006;123(4):297-311.
2006: Colin E Murdoch; David J Grieve; Alison C Cave; Yee Hoo Looi; Ajay M Shah
NADPH oxidase and heart failure.
Current opinion in pharmacology 2006;6(2):148-53.
2006: Min Zhang; Ay Lin Kho; Narayana Anilkumar; Rakesh Chibber; Patrick J Pagano; Ajay M Shah; Alison C Cave
Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase.
Circulation 2006;113(9):1235-43.
2006: David J Grieve; Jonathan A Byrne; Anjana Siva; Joanne Layland; Sofian Johar; Alison C Cave; Ajay M Shah
Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload.
Journal of the American College of Cardiology 2006;47(4):817-26.
2006: Alison C Brewer; Emma C Sparks; Ajay M Shah
Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: role of GATA-binding factor(s).
Free radical biology & medicine 2006;40(2):260-74.
2005: Alison C Cave; David J Grieve; Sofian Johar; Min Zhang; Ajay M Shah
NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2327-34.
2005: Robert M Bell; Alison C Cave; Sofian Johar; David J Hearse; Ajay M Shah; Michael J Shattock
Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2037-9.
2005: Robin Ray; Ajay M Shah
NADPH oxidase and endothelial cell function.
Clinical science (London, England : 1979) 2005;109(3):217-26.
2005: Edward R Duncan; Ajay M Shah; M T Kearney
Obesity and endothelial function.
Circulation research 2005;97(4):e52.
2005: Alison C Brewer; Alexander Alexandrovich; Corey H Mjaatvedt; Ajay M Shah; Roger Patient; John Pizzey
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
Stem cells and development 2005;14(4):425-39.
2005: Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet Patel; Roy A Sherwood; Aziz U Momin; Ajay M Shah; Mark T Kearney
Endothelial function and weight loss in obese humans.
Obesity surgery 2005;15(7):1055-60.
2005: Joanne Layland; Alison C Cave; Chad Warren; David J Grieve; Emma Sparks; Jonathan C Kentish; R John Solaro; Ajay M Shah
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1137-9.
2005: Ajay M Shah
Divergent roles of endothelial nitric oxide synthase in cardiac hypertrophy and chamber dilatation?
Cardiovascular research 2005;66(3):421-2.
2005: Thuraia Nageh; Roy A Sherwood; Ray J Wainwright; Ajay M Shah; Martyn R Thomas
The clinical relevance of raised cardiac troponin I in the absence of significant angiographic coronary artery disease.
International journal of cardiology 2005;100(2):325-30.
2005: Brian T Noronha; Jian-Mei Li; Stephen B Wheatcroft; Ajay M Shah; Mark T Kearney
Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity.
Diabetes 2005;54(4):1082-9.
2005: Joanne Layland; R John Solaro; Ajay M Shah
Regulation of cardiac contractile function by troponin I phosphorylation.
Cardiovascular research 2005;66(1):12-21.
2005: Jian-Mei Li; Lampson M Fan; Michael R Christie; Ajay M Shah
Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.
Molecular and cellular biology 2005;25(6):2320-30.
2005: A Siva; Ajay M Shah
Moderate mitral stenosis in pregnancy: the haemodynamic impact of diuresis.
Heart (British Cardiac Society) 2005;91(1):e3.
2004: Jian-Mei Li; Ajay M Shah
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(5):R1014-30.
2004: Ziad Mallat; Christophe Heymes; Anne Corbaz; Damien Logeart; Sami Alouani; Alain Cohen-Solal; Tim Seidler; Gerd Hasenfuss; Yolande Chvatchko; Ajay M Shah; Alain Tedgui
Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1752-4.
2004: Stephen B Wheatcroft; Ajay M Shah; Jian-Mei Li; Edward Duncan; Brian T Noronha; Paul A Crossey; Mark T Kearney
Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor.
Diabetes 2004;53(10):2645-52.
2004: Mark T Kearney; Keith A A Fox; A J Lee; W Paul Brooksby; Ajay M Shah; Andrew D Flapan; Robin J Prescott; R Andrews; Philip D Batin; Dwain L Eckberg; Nicholas P Gall; Azfar G Zaman; H S Lindsay; J Nolan
Predicting sudden death in patients with mild to moderate chronic heart failure.
Heart (British Cardiac Society) 2004;90(10):1137-43.
2004: David J Grieve; Alison C Cave; Jonathan A Byrne; Joanne Layland; Ajay M Shah
Analysis of ex vivo left ventricular pressure-volume relations in the isolated murine ejecting heart.
Experimental physiology 2004;89(5):573-82.
2004: Yasin Heidari; Ajay M Shah; Chris Gove
NOX-2S is a new member of the NOX family of NADPH oxidases.
Gene 2004;335():133-40.
2004: David J Grieve; Jonathan A Byrne; Alison C Cave; Ajay M Shah
Role of oxidative stress in cardiac remodelling after myocardial infarction.
Heart, lung & circulation 2004;13(2):132-8.
2004: Ajay M Shah; K M Channon
Free radicals and redox signalling in cardiovascular disease.
Heart (British Cardiac Society) 2004;90(5):486-7.
2004: Joanne Layland; David J Grieve; Alison C Cave; Emma Sparks; R John Solaro; Ajay M Shah
Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically.
The Journal of physiology 2004;556(Pt 3):835-47.
2004: Thibaud Damy; Philippe Ratajczak; Ajay M Shah; Emmanuel Camors; Isabelle Marty; Gerd Hasenfuss; Françoise Marotte; Jane-Lise Samuel; Christophe Heymes
Increased neuronal nitric oxide synthase-derived NO production in the failing human heart.
Lancet 2004;363(9418):1365-7.
2004: Jian-Mei Li; Stephen B Wheatcroft; Lampson M Fan; Mark T Kearney; Ajay M Shah
Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.
Circulation 2004;109(10):1307-13.
2004: Magdi M El-Omar; Zhao-Kang Yang; Aled O Phillips; Ajay M Shah
Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus.
Basic research in cardiology 2004;99(2):133-41.
2003: David J Grieve; Ajay M Shah
Oxidative stress in heart failure. More than just damage.
European heart journal 2003;24(24):2161-3.
2003: Jonathan A Byrne; David J Grieve; Jennifer K Bendall; Jian-Mei Li; Christopher Gove; David J. Lambeth; Alison C Cave; Ajay M Shah
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.
Circulation research 2003;93(9):802-5.
2003: Mark T Kearney; James Nolan; Amanda J Lee; Paul W Brooksby; Robin J Prescott; Ajay M Shah; Azfar G Zaman; Dwain L Eckberg; H Stephen Lindsay; Philip D Batin; Richard Andrews; Keith A A Fox
A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.
European journal of heart failure 2003;5(4):489-97.
2003: Stephen B Wheatcroft; Mark T Kearney; Ajay M Shah; David J Grieve; Ian L Williams; John P Miell; Paul A Crossey
Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.
Diabetes 2003;52(8):2075-82.
2003: Jian-Mei Li; Ajay M Shah
ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S221-6.
2003: Philip A MacCarthy; Mark T Kearney; James Nolan; Amanda J Lee; Robin J Prescott; Ajay M Shah; W Paul Brooksby; Keith A A Fox
Prognosis in heart failure with preserved left ventricular systolic function: prospective cohort study.
BMJ (Clinical research ed.) 2003;327(7406):78-9.
2003: Christophe Heymes; Jennifer K Bendall; Philippe Ratajczak; Alison C Cave; Jane-Lise Samuel; Gerd Hasenfuss; Ajay M Shah
Increased myocardial NADPH oxidase activity in human heart failure.
Journal of the American College of Cardiology 2003;41(12):2164-71.
2003: Magdi M El-Omar; Roger Lord; Nick J Draper; Ajay M Shah
Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy.
European journal of heart failure 2003;5(3):229-39.
2003: Jian-Mei Li; Ajay M Shah
Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.
The Journal of biological chemistry 2003;278(14):12094-100.
2003: Mark T Kearney; Azfar Zaman; Dwain L Eckberg; Amanda J Lee; Keith A A Fox; Ajay M Shah; Robin J Prescott; William E Shell; Elizabeth Charuvastra; Timothy S Callahan; W Paul Brooksby; D Justin Wright; Nicholas P Gall; James Nolan
Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation.
Journal of cardiac failure 2003;9(2):93-9.
2003: Stephen B Wheatcroft; Ian L Williams; Ajay M Shah; M T Kearney
Pathophysiological implications of insulin resistance on vascular endothelial function.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(4):255-68.
2003: Philip A MacCarthy; Ajay M Shah
Oxidative stress and heart failure.
Coronary artery disease 2003;14(2):109-13.
2003: Jonathan A Byrne; David J Grieve; Alison C Cave; Ajay M Shah
Oxidative stress and heart failure.
Archives des maladies du coeur et des vaisseaux 2003;96(3):214-21.
2002: J M Cotton; Mark T Kearney; Ajay M Shah
Nitric oxide and myocardial function in heart failure: friend or foe?
Heart (British Cardiac Society) 2002;88(6):564-6.
2002: Mark T Kearney; Keith A A Fox; Amanda J Lee; Robin J Prescott; Ajay M Shah; Philip D Batin; Wazir Baig; Stephen Lindsay; Timothy S Callahan; William E Shell; Dwain L Eckberg; Azfar G Zaman; Simon Williams; James M M Neilson; James Nolan
Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure.
Journal of the American College of Cardiology 2002;40(10):1801-8.
2002: M G Gunning; IL Williams; David E Jewitt; Ajay M Shah; Ray J Wainwright; Martyn R Thomas
Coronary artery perforation during percutaneous intervention: incidence and outcome.
Heart (British Cardiac Society) 2002;88(5):495-8.
2002: Jennifer K Bendall; Christophe Heymes; Timothy J F Wright; Stephen B Wheatcroft; David J Grieve; Ajay M Shah; Alison C Cave
Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart.
Journal of molecular and cellular cardiology 2002;34(10):1325-33.
2002: Jian-Mei Li; Nick P Gall; David J Grieve; Mingyou Chen; Ajay M Shah
Activation of NADPH oxidase during progression of cardiac hypertrophy to failure.
Hypertension 2002;40(4):477-84.
2002: Ian L Williams; Stephen B Wheatcroft; Ajay M Shah; Mark T Kearney
Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(6):754-64.
2002: Jian-Mei Li; Ajay M Shah
Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells.
The Journal of biological chemistry 2002;277(22):19952-60.
2002: Mark T Kearney; Philip J Chowienczyk; Sally E Brett; Angela Sutcliffe; James M Ritter; Ajay M Shah
Acute haemodynamic effects of lipolysis-induced increase of free fatty acids in healthy men.
Clinical science (London, England : 1979) 2002;102(5):495-500.
2002: Joanne Layland; Jian-Mei Li; Ajay M Shah
Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes.
The Journal of physiology 2002;540(Pt 2):457-67.
2002: Jian-Mei Li; Adrian M Mullen; Sheng Yun; Frans Wientjes; Gabi Y Brouns; Adrian J Thrasher; Ajay M Shah
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.
Circulation research 2002;90(2):143-50.
2002: Jennifer K Bendall; Alison C Cave; Christophe Heymes; Nick P Gall; Ajay M Shah
Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.
Circulation 2002;105(3):293-6.
2001: Philip A MacCarthy; David J Grieve; Jian-Mei Li; Christina Dunster; Frank Kelly; Ajay M Shah
Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase.
Circulation 2001;104(24):2967-74.
2001: Jian-Mei Li; Ajay M Shah
Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase.
Cardiovascular research 2001;52(3):477-86.
2001: J M Cotton; Mark T Kearney; Philip A MacCarthy; RM Grocott-Mason; Dougal R McClean; Christophe Heymes; Peter J Richardson; Ajay M Shah
Effects of nitric oxide synthase inhibition on Basal function and the force-frequency relationship in the normal and failing human heart in vivo.
Circulation 2001;104(19):2318-23.
2001: David J Grieve; Philip A MacCarthy; Nick P Gall; Alison C Cave; Ajay M Shah
Divergent biological actions of coronary endothelial nitric oxide during progression of cardiac hypertrophy.
Hypertension 2001;38(2):267-73.
2001: J M Li; A M Mullen; Ajay M Shah
Phenotypic properties and characteristics of superoxide production by mouse coronary microvascular endothelial cells.
Journal of molecular and cellular cardiology 2001;33(6):1119-31.
2001: B Tavernier; Jian-Mei Li; Magdi M El-Omar; Sophie Lanone; Zhao-Kang Yang; I P Trayer; Alexandre Mebazaa; Ajay M Shah
Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):294-6.
2001: PA MacCarthy; N C Pegge; BD Prendergast; Ajay M Shah; P H Groves
The physiological role of endogenous endothelin in the regulation of human coronary vasomotor tone.
Journal of the American College of Cardiology 2001;37(1):137-43.
2001: Mark T Kearney; J M Cotton; Peter J Richardson; Ajay M Shah
Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management.
Postgraduate medical journal 2001;77(903):4-10.
2000: Joanne Layland; Ajay M Shah
Molecular signalling in cardiovascular biology: from molecules to man. International symposium organized by the centre for cardiovascular biology and medicine, King's College, London.
Molecular medicine today 2000;6(9):342-4.
2000: U Bayraktutan; L Blayney; Ajay M Shah
Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(8):1903-11.
2000: PA MacCarthy; Ajay M Shah
Impaired endothelium-dependent regulation of ventricular relaxation in pressure-overload cardiac hypertrophy.
Circulation 2000;101(15):1854-60.
2000: Ajay M Shah; Philip A MacCarthy
Paracrine and autocrine effects of nitric oxide on myocardial function.
Pharmacology & therapeutics 2000;86(1):49-86.
2000: PA MacCarthy; RM Grocott-Mason; BD Prendergast; Ajay M Shah
Contrasting inotropic effects of endogenous endothelin in the normal and failing human heart: studies with an intracoronary ET(A) receptor antagonist.
Circulation 2000;101(2):142-7.
2000: Ajay M Shah
Inducible nitric oxide synthase and cardiovascular disease.
Cardiovascular research 2000;45(1):148-55.
1999: W J Paulus; Ajay M Shah
NO and cardiac diastolic function.
Cardiovascular research 1999;43(3):595-606.
1999: Peter B Anning; BD Prendergast; PA MacCarthy; Ajay M Shah; D C Buss; Malcolm J Lewis
ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart.
The American journal of physiology 1999;277(2 Pt 2):H818-25.
1999: D Lang; J P Bell; U Bayraktutan; G R Small; Ajay M Shah; Malcolm J Lewis
Phenotypic changes in rat and guinea pig coronary microvascular endothelium after culture: loss of nitric oxide synthase activity.
Cardiovascular research 1999;42(3):794-804.
1999: Zhao-Kang Yang; Nick J Draper; Ajay M Shah
Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts.
The American journal of physiology 1999;276(2 Pt 2):H623-32.
1998: Alexandre Mebazaa; R C Wetzel; Jeffrey M Dodd-o; E M Redmond; Ajay M Shah; K Maeda; Geneviève Maistre; Edward G Lakatta; JL Robotham
Potential paracrine role of the pericardium in the regulation of cardiac function.
Cardiovascular research 1998;40(2):332-42.
1998: BD Prendergast; PA MacCarthy; J F Wilson; Ajay M Shah
Nitric oxide enhances the inotropic response to beta-adrenergic stimulation in the isolated guinea-pig heart.
Basic research in cardiology 1998;93(4):276-84.
1998: Ajay M Shah; STEVEN SOLLOTT; Edward G Lakatta
Physio-pharmacological evaluation of myocardial performance: an integrative approach.
Cardiovascular research 1998;39(1):148-54.
1998: U Bayraktutan; Zhao-Kang Yang; Ajay M Shah
Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat.
Cardiovascular research 1998;38(3):719-26.
1998: U Bayraktutan; Nick J Draper; D Lang; Ajay M Shah
Expression of functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells.
Cardiovascular research 1998;38(1):256-62.
1998: RM Grocott-Mason; Ajay M Shah
Cardiac dysfunction in sepsis: new theories and clinical implications.
Intensive care medicine 1998;24(4):286-95.
1997: BD Prendergast; V F Sagach; Ajay M Shah
Basal release of nitric oxide augments the Frank-Starling response in the isolated heart.
Circulation 1997;96(4):1320-9.
1997: Ajay M Shah; Alexandre Mebazaa; Zhao-Kang Yang; Giovanni Cuda; E B Lankford; C B Pepper; STEVEN SOLLOTT; James R Sellers; JL Robotham; Edward G Lakatta
Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand?
Circulation research 1997;80(5):688-98.
1997: Nick J Draper; Ajay M Shah
Beneficial effects of a nitric oxide donor on recovery of contractile function following brief hypoxia in isolated rat heart.
Journal of molecular and cellular cardiology 1997;29(4):1195-205.
1997: BD Prendergast; Peter B Anning; Malcolm J Lewis; Ajay M Shah
Regulation of left ventricular relaxation in the isolated guinea-pig heart by endogenous endothelin.
Cardiovascular research 1997;33(1):131-8.
1996: Ajay M Shah; RM Grocott-Mason; C B Pepper; A Mebazaa; Andrew H Henderson; Malcolm J Lewis; W J Paulus
The cardiac endothelium: cardioactive mediators.
Progress in cardiovascular diseases 1996;39(3):263-84.
1996: Ajay M Shah
Paracrine modulation of heart cell function by endothelial cells.
Cardiovascular research 1996;31(6):847-67.
1995: Ajay M Shah
Decreased myocardial contractility after damage to endocardial endothelium is caused mainly by loss of endothelin production.
Cardiovascular research 1995;30(5):644-5.
1995: Peter B Anning; RM Grocott-Mason; Malcolm J Lewis; Ajay M Shah
Enhancement of left ventricular relaxation in the isolated heart by an angiotensin-converting enzyme inhibitor.
Circulation 1995;92(9):2660-5.
1995: C B Pepper; D Lang; Malcolm J Lewis; Ajay M Shah
Endothelial inhibition of myofilament calcium response in intact cardiac myocytes.
The American journal of physiology 1995;269(5 Pt 2):H1538-44.
1995: W J Paulus; P J Vantrimpont; Ajay M Shah
Paracrine coronary endothelial control of left ventricular function in humans.
Circulation 1995;92(8):2119-26.
1995: Ajay M Shah; BD Prendergast; RM Grocott-Mason; Malcolm J Lewis; W J Paulus
The influence of endothelium-derived nitric oxide on myocardial contractile function.
International journal of cardiology 1995;50(3):225-31.
1995: Ajay M Shah; HS Silverman; Elinor J Griffiths; Harold A Spurgeon; Edward G Lakatta
cGMP prevents delayed relaxation at reoxygenation after brief hypoxia in isolated cardiac myocytes.
The American journal of physiology 1995;268(6 Pt 2):H2396-204.
1994: H G Evans; Malcolm J Lewis; Ajay M Shah
Modulation of myocardial relaxation by basal release of endothelin from endocardial endothelium.
Cardiovascular research 1994;28(11):1694-9.
1994: RM Grocott-Mason; Peter B Anning; H Evans; Malcolm J Lewis; Ajay M Shah
Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide.
The American journal of physiology 1994;267(5 Pt 2):H1804-13.
1994: Ajay M Shah; Alexandre Mebazaa; R C Wetzel; Edward G Lakatta
Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells.
Circulation 1994;89(6):2492-7.
1994: RM Grocott-Mason; S Fort; Malcolm J Lewis; Ajay M Shah
Myocardial relaxant effect of exogenous nitric oxide in isolated ejecting hearts.
The American journal of physiology 1994;266(5 Pt 2):H1699-705.
1994: Ajay M Shah; Harold A Spurgeon; STEVEN SOLLOTT; A Talo; Edward G Lakatta
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Circulation research 1994;74(5):970-8.
1994: W J Paulus; P J Vantrimpont; Ajay M Shah
Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion.
Circulation 1994;89(5):2070-8.
1993: S Fort; Malcolm J Lewis; Ajay M Shah
The role of endocardial endothelium in the modulation of myocardial contraction in the isolated whole heart.
Cardioscience 1993;4(4):217-23.
1993: Alexandre Mebazaa; E Mayoux; K Maeda; Lynn D Martin; Edward G Lakatta; JL Robotham; Ajay M Shah
Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin.
The American journal of physiology 1993;265(5 Pt 2):H1841-6.
1993: H G Evans; Malcolm J Lewis; Ajay M Shah
Interleukin-1 beta modulates myocardial contraction via dexamethasone sensitive production of nitric oxide.
Cardiovascular research 1993;27(8):1486-90.
1993: Ajay M Shah; Malcolm J Lewis
Modulation of myocardial contraction by endocardial and coronary vascular endothelium.
Trends in cardiovascular medicine 1993;3(3):98-103.
1992: H G Evans; Ajay M Shah; Malcolm J Lewis
Cyclic GMP inhibits the inotropic response to alpha 1-adrenoceptors in the papillary muscle of the ferret.
Cardioscience 1992;3(4):257-64.
1992: Ajay M Shah
Vascular endothelium.
British journal of hospital medicine 1992;48(9):540-9.
1992: Ajay M Shah; M J Shattock; Malcolm J Lewis
Action potential duration and endocardial modulation of myocardial contraction in the ferret.
Cardiovascular research 1992;26(4):376-8.
1992: Andrew H Henderson; Malcolm J Lewis; Ajay M Shah; J A Smith
Endothelium, endocardium, and cardiac contraction.
Cardiovascular research 1992;26(4):305-8.
1992: J A Smith; Ajay M Shah; S Fort; Malcolm J Lewis
The influence of endocardial endothelium on myocardial contraction.
Trends in pharmacological sciences 1992;13(3):113-6.
1992: Ajay M Shah; M J Lewis
Endothelial modulation of myocardial contraction: mechanisms and potential relevance in cardiac disease.
Basic research in cardiology 1992;87 Suppl 2():59-70.
1991: J A Smith; Ajay M Shah; Malcolm J Lewis
Factors released from endocardium of the ferret and pig modulate myocardial contraction.
The Journal of physiology 1991;439():1-14.
1991: Ajay M Shah; Malcolm J Lewis; Andrew H Henderson
Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle.
Journal of molecular and cellular cardiology 1991;23(1):55-64.
1990: Malcolm J Lewis; Ajay M Shah; J A Smith; Andrew H Henderson
Does endocardium modulate myocardial contractile performance?
Cardioscience 1990;1(2):83-7.
1989: Ajay M Shah; Malcolm J Lewis; Andrew H Henderson
Inotropic effects of endothelin in ferret ventricular myocardium.
European journal of pharmacology 1989;163(2-3):365-7.