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John Blenis

Research Profile

Chemicals & Drugs

Physiology

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Alfredo Csibi; Jamie M Dempsey; Sarah-Maria Fendt; Marcia Haigis; Elizabeth P Henske; Seung Min Jeong; Chenggang Li; Tasha Morrison; Andrey Parkhitko; George Poulogiannis; Gregory Stephanopoulos; Jane Yu; Lewis C Cantley; Douglas J Chapski; Andrew Y Choo; John Blenis
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4.
Gwen R Buel; Sang Gyun Kim; John Blenis
mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis.
Seung Min Jeong; Alec C Kimmelman; Tyler Lahusen; Gaëlle Laurent; Jaewon Lee; Cuiling Li; Ying-Hua Li; Kerry Pierce; Amanda L Souza; Rui-Hong Wang; Xiaoxu Wang; Cuiying Xiao; Xiaoling Xu; John Blenis; Richard Cerione; Clary B Clish; Alfredo Csibi; Chu-Xia Deng; Lydia W S Finley; Natalie J German; Marcia Haigis
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism.

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All Publications

2013: Alfredo Csibi; Jamie M Dempsey; Sarah-Maria Fendt; Marcia Haigis; Elizabeth P Henske; Seung Min Jeong; Chenggang Li; Tasha Morrison; Andrey Parkhitko; George Poulogiannis; Gregory Stephanopoulos; Jane Yu; Lewis C Cantley; Douglas J Chapski; Andrew Y Choo; John Blenis
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4.
Cell 2013;153(4):840-54.
2013: Gwen R Buel; Sang Gyun Kim; John Blenis
mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis.
Cell metabolism 2013;17(5):633-5.
2013: Seung Min Jeong; Alec C Kimmelman; Tyler Lahusen; Gaëlle Laurent; Jaewon Lee; Cuiling Li; Ying-Hua Li; Kerry Pierce; Amanda L Souza; Rui-Hong Wang; Xiaoxu Wang; Cuiying Xiao; Xiaoling Xu; John Blenis; Richard Cerione; Clary B Clish; Alfredo Csibi; Chu-Xia Deng; Lydia W S Finley; Natalie J German; Marcia Haigis
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism.
Cancer cell 2013;23(4):450-63.
2013: Sang Gyun Kim; Ki Won Lee; George Poulogiannis; Gwen R Buel; Lewis C Cantley; Andrew Y Choo; Raymond L Erikson; Gregory R Hoffman; Young Jin Jang; Bo-Yeon Kim; John Blenis
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Molecular cell 2013;49(1):172-85.
2012: Alfred Csibi; John Blenis
Hippo-YAP and mTOR pathways collaborate to regulate organ size.
Nature cell biology 2012;14(12):1244-5.
2012: Rana Anjum; John Blenis; Eunice Pae; Bryan A Ballif
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues.
FEBS letters 2012;586(19):3471-6.
2012: Wenjuan Zhang; Yingmei Zhang; John Blenis; Didem Ilter; Dalong Ma; Sarah J Mahoney; Michelle C Mendoza; Xiaolei Pei; Ying Wang
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.
The Journal of biological chemistry 2012;287(15):11850-8.
2011: Sejeong Shin; Laura Wolgamott; John Blenis; Yonghao Yu; Sang-Oh Yoon
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):E1204-13.
2011: Yonghao Yu; Lewis C Cantley; Steven P Gygi; Gregory R Hoffman; Neil Kubica; Xiaoju Max Ma; George Poulogiannis; Judit Villén; Qian Yang; Sang-Oh Yoon; John Blenis
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Science (New York, N.Y.) 2011;332(6035):1322-6.
2011: Michelle C Mendoza; E Emrah Er; John Blenis
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.
Trends in biochemical sciences 2011;36(6):320-8.
2011: Michelle C Mendoza; E Emrah Er; Wenjuan Zhang; Bryan A Ballif; Hunter L Elliott; Gaudenz Danuser; John Blenis
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
Molecular cell 2011;41(6):661-71.
2011: Alfredo Csibi; John Blenis
Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors.
BMC biology 2011;9():69.
2010: Sang Gyun Kim; Andrew Y Choo; John Blenis
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.
Molecular cell 2010;40(4):501-2.
2010: Sejeong Shin; John Blenis
ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition.
Cell cycle (Georgetown, Tex.) 2010;9(13):2483-4.
2010: Marta Lipinski; Greg Hoffman; Aylwin Ng; Wen Zhou; Benedicte F Py; Emily Hsu; Xuxin Liu; Jason Eisenberg; Jun Liu; John Blenis; Ramnik J Xavier; Junying Yuan
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.
Developmental cell 2010;18(6):1041-52.
2010: Andrew Y Choo; Sang Gyun Kim; Matthew G Vander Heiden; Sarah J Mahoney; Hieu Vu; Sang-Oh Yoon; Lewis C Cantley; John Blenis
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.
Molecular cell 2010;38(4):487-99.
2010: Sejeong Shin; Christopher A Dimitri; Sang-Oh Yoon; William Dowdle; John Blenis
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.
Molecular cell 2010;38(1):114-27.
2010: Gregory R Hoffman; Nathan J Moerke; Max Hsia; CE Shamu; John Blenis
A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique.
Assay and drug development technologies 2010;8(2):186-99.
2010: Michelle C Mendoza; Ekrem Emrah Er; John Blenis
ERK-MAP Kinase signaling in the cytoplasm.
Methods in molecular biology (Clifton, N.J.) 2010;661():185-203.
2009: Yuki Abe; Sang-Oh Yoon; Kazuishi Kubota; Michelle C Mendoza; Steven P Gygi; John Blenis
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
The Journal of biological chemistry 2009;284(22):14939-48.
2009: Xiaoju Max Ma; John Blenis
Molecular mechanisms of mTOR-mediated translational control.
Nature reviews. Molecular cell biology 2009;10(5):307-18.
2009: Andrew Y Choo; John Blenis
Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy.
Cell cycle (Georgetown, Tex.) 2009;8(4):567-72.
2009: Sarah J Mahoney; Jamie M Dempsey; John Blenis
Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation.
Progress in molecular biology and translational science 2009;90():53-107.
2009: Rod A Rahimi; Mahefatiana Andrianifahanana; Mark C Wilkes; Maryanne Edens; Theodore J Kottom; John Blenis; Edward B Leof
Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta.
Cancer research 2009;69(1):84-93.
2008: Andrew Y Choo; Sang-Oh Yoon; Sang Gyun Kim; Philippe Roux; John Blenis
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17414-9.
2008: Rana Anjum; John Blenis
The RSK family of kinases: emerging roles in cellular signalling.
Nature reviews. Molecular cell biology 2008;9(10):747-58.
2008: Jidong Zhu; John Blenis; Junying Yuan
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6584-9.
2008: Xiaoju Max Ma; Sang-Oh Yoon; Celeste J Richardson; Kristina Jülich; John Blenis
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.
Cell 2008;133(2):303-13.
2008: Sang-Oh Yoon; Sejeong Shin; Yuzhen Liu; Bryan A Ballif; Michele S Woo; Steven P Gygi; John Blenis
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport.
Molecular cell 2008;29(3):362-75.
2008: Audrey Carriere; Hind Ray; John Blenis; Philippe Roux
The RSK factors of activating the Ras/MAPK signaling cascade.
Frontiers in bioscience : a journal and virtual library 2008;13():4258-75.
2007: Philippe Roux; David Shahbazian; Hieu Vu; Marina K Holz; Michael S Cohen; Jack Taunton; Nahum Sonenberg; John Blenis
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
The Journal of biological chemistry 2007;282(19):14056-64.
2007: Michelle C Mendoza; John Blenis
PHLPPing it off: phosphatases get in the Akt.
Molecular cell 2007;25(6):798-800.
2007: Christina Ivins Zito; Hui Qin; John Blenis; Anton M Bennett
SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway.
The Journal of biological chemistry 2007;282(10):6946-53.
2006: Andrew Y Choo; Philippe Roux; John Blenis
Mind the GAP: Wnt steps onto the mTORC1 train.
Cell 2006;126(5):834-6.
2006: Myungjin Kim; Jun Hee Lee; Hyongjong Koh; Soo Young Lee; Cholsoon Jang; Cecilia J Chung; Jung Hwan Sung; John Blenis; Jongkyeong Chung
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.
The EMBO journal 2006;25(13):3056-67.
2006: David Shahbazian; Philippe Roux; Virginie Mieulet; Michael S Cohen; Brian Raught; Jack Taunton; John W B Hershey; John Blenis; Mario Pende; Nahum Sonenberg
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
The EMBO journal 2006;25(12):2781-91.
2006: Leon O Murphy; John Blenis
MAPK signal specificity: the right place at the right time.
Trends in biochemical sciences 2006;31(5):268-75.
2006: Jo C Lewthwaite; Edward R Bastow; Katherine J Lamb; John Blenis; Caroline P D Wheeler-Jones; Andrew A Pitsillides
A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation.
The Journal of biological chemistry 2006;281(16):11011-8.
2006: Andrew Y Choo; John Blenis
TORgeting oncogene addiction for cancer therapy.
Cancer cell 2006;9(2):77-9.
2006: Jessie Hanrahan; John Blenis
Rheb activation of mTOR and S6K1 signaling.
Methods in enzymology 2006;407():542-55.
2005: Marina K Holz; Bryan A Ballif; Steven P Gygi; John Blenis
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
Cell 2005;123(4):569-80.
2005: Rana Anjum; Philippe Roux; Bryan A Ballif; Steven P Gygi; John Blenis
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
Current biology : CB 2005;15(19):1762-7.
2005: Andrew R Tee; John Blenis; Christopher G Proud
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
FEBS letters 2005;579(21):4763-8.
2005: Christopher A Dimitri; William Dowdle; Jeffrey P MacKeigan; John Blenis; Leon O Murphy
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
Current biology : CB 2005;15(14):1319-24.
2005: Marina K Holz; John Blenis
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
The Journal of biological chemistry 2005;280(28):26089-93.
2005: Jeffrey P MacKeigan; Leon O Murphy; Christopher A Dimitri; John Blenis
Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.
Molecular and cellular biology 2005;25(11):4676-82.
2005: Jeffrey P MacKeigan; Leon O Murphy; John Blenis
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.
Nature cell biology 2005;7(6):591-600.
2005: Stefanie S Schalm; Andrew R Tee; John Blenis
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation.
The Journal of biological chemistry 2005;280(12):11101-6.
2005: Andrew R Tee; John Blenis
mTOR, translational control and human disease.
Seminars in cell & developmental biology 2005;16(1):29-37.
2005: Bryan A Ballif; Philippe Roux; Scott A Gerber; Jeffrey P MacKeigan; John Blenis; Steven P Gygi
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):667-72.
2004: Philippe Roux; Bryan A Ballif; Rana Anjum; Steven P Gygi; John Blenis
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13489-94.
2004: Celeste J Richardson; Mark Bröenstrup; Diane C Fingar; Kristina Jülich; Bryan A Ballif; Steven P Gygi; John Blenis
SKAR is a specific target of S6 kinase 1 in cell growth control.
Current biology : CB 2004;14(17):1540-9.
2004: Julie R McMullen; Tetsuo Shioi; Li Zhang; Oleg Tarnavski; Megan C Sherwood; Adam L Dorfman; Sarah Longnus; Mario Pende; Kathleen A Martin; John Blenis; George Thomas; Seigo Izumo
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.
Molecular and cellular biology 2004;24(14):6231-40.
2004: Philippe Roux; John Blenis
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
Microbiology and molecular biology reviews : MMBR 2004;68(2):320-44.
2004: Andrew R Tee; Jennifer A Tee; John Blenis
Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.
FEBS letters 2004;564(1-2):58-62.
2004: Diane C Fingar; John Blenis
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
Oncogene 2004;23(18):3151-71.
2004: Celeste J Richardson; Stefanie S Schalm; John Blenis
PI3-kinase and TOR: PIKTORing cell growth.
Seminars in cell & developmental biology 2004;15(2):147-59.
2004: Michele S Woo; Yasutaka Ohta; Isaac Rabinovitz; Thomas P Stossel; John Blenis
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.
Molecular and cellular biology 2004;24(7):3025-35.
2004: Diane C Fingar; Celeste J Richardson; Andrew R Tee; Lynn Cheatham; Christina Tsou; John Blenis
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.
Molecular and cellular biology 2004;24(1):200-16.
2004: Leon O Murphy; Jeffrey P MacKeigan; John Blenis
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.
Molecular and cellular biology 2004;24(1):144-53.
2004: Yong Qian; Linda Corum; Qiao Meng; John Blenis; Jenny Z Zheng; Xianglin Shi; Daniel C Flynn; Bing-Hua Jiang
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration.
American journal of physiology. Cell physiology 2004;286(1):C153-63.
2003: Sudhanshu Agrawal; Anshu Agrawal; Barbara Doughty; Andrew Gerwitz; John Blenis; Thomas Van Dyke; Bali Pulendran
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):4984-9.
2003: Andrew R Tee; Rana Anjum; John Blenis
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin.
The Journal of biological chemistry 2003;278(39):37288-96.
2003: Andrew R Tee; Brendan D Manning; Philippe Roux; Lewis C Cantley; John Blenis
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Current biology : CB 2003;13(15):1259-68.
2003: Philippe Roux; Stephanie A Richards; John Blenis
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.
Molecular and cellular biology 2003;23(14):4796-804.
2003: Stefanie S Schalm; Diane C Fingar; David M Sabatini; John Blenis
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.
Current biology : CB 2003;13(10):797-806.
2002: Angela Romanelli; Valley C Dreisbach; John Blenis
Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.
The Journal of biological chemistry 2002;277(43):40281-9.
2002: Andrew R Tee; Diane C Fingar; Brendan D Manning; David J Kwiatkowski; Lewis C Cantley; John Blenis
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13571-6.
2002: Leon O Murphy; Sallie Smith; Rey-Huei Chen; Diane C Fingar; John Blenis
Molecular interpretation of ERK signal duration by immediate early gene products.
Nature cell biology 2002;4(8):556-64.
2002: Brendan D Manning; Andrew R Tee; M Nicole Logsdon; John Blenis; Lewis C Cantley
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Molecular cell 2002;10(1):151-62.
2002: Diane C Fingar; Sofie Salama; Christina Tsou; Ed Harlow; John Blenis
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.
Genes & development 2002;16(12):1472-87.
2002: Stefanie S Schalm; John Blenis
Identification of a conserved motif required for mTOR signaling.
Current biology : CB 2002;12(8):632-9.
2002: Kathleen A Martin; John Blenis
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways.
Advances in cancer research 2002;86():1-39.
2001: Stephanie A Richards; Valley C Dreisbach; Leon O Murphy; John Blenis
Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1.
Molecular and cellular biology 2001;21(21):7470-80.
2001: Daniela Siegmund; D Mauri; Nathalie Peters; Peter Juo; M Thome; Monica Reichwein; John Blenis; Peter Scheurich; Jürg Tschopp; Harald Wajant
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
The Journal of biological chemistry 2001;276(35):32585-90.
2001: Bryan A Ballif; John Blenis
Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(8):397-408.
2001: Chang-Yan Chen; Peter Juo; James S Liou; C Q Li; Q Yu; John Blenis; Douglas V Faller
The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(6):297-306.
2001: Bryan A Ballif; A Shimamura; E Pae; John Blenis
Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone.
The Journal of biological chemistry 2001;276(15):12466-75.
2001: Kathleen A Martin; Stefanie S Schalm; Angela Romanelli; K L Keon; John Blenis
Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation.
The Journal of biological chemistry 2001;276(11):7892-8.
2001: Kathleen A Martin; Stefanie S Schalm; C Richardson; Angela Romanelli; K L Keon; John Blenis
Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway.
The Journal of biological chemistry 2001;276(11):7884-91.
2001: Kristen J Verhey; D Meyer; R Deehan; John Blenis; Bruce J Schnapp; Tom A Rapoport; Benjamin L Margolis
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.
The Journal of cell biology 2001;152(5):959-70.
2000: Hanfei Ding; Y L Lin; Gaël G McGill; Peter Juo; H Zhu; John Blenis; Junying Yuan; David E Fisher
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53.
The Journal of biological chemistry 2000;275(49):38905-11.
2000: Martin Sprick; Markus A Weigand; Eva Rieser; C T Rauch; Peter Juo; John Blenis; Peter H Krammer; Henning Walczak
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
Immunity 2000;12(6):599-609.
2000: Jean-Luc Bodmer; Nils Holler; S Reynard; Patrizia Vinciguerra; Pascal Schneider; Peter Juo; John Blenis; Jürg Tschopp
TRAIL receptor-2 signals apoptosis through FADD and caspase-8.
Nature cell biology 2000;2(4):241-3.
2000: A Shimamura; Bryan A Ballif; Stephanie A Richards; John Blenis
Rsk1 mediates a MEK-MAP kinase cell survival signal.
Current biology : CB 2000;10(3):127-35.
1999: Peter Juo; M S Woo; CJ Kuo; P Signorelli; H P Biemann; Yusuf A Hannun; John Blenis
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(12):797-804.
1999: K K Lee-Fruman; C J Kuo; J Lippincott; N Terada; John Blenis
Characterization of S6K2, a novel kinase homologous to S6K1.
Oncogene 1999;18(36):5108-14.
1999: Stephanie A Richards; J Fu; Angela Romanelli; A Shimamura; John Blenis
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.
Current biology : CB 1999;9(15):810-20.
1999: Angela Romanelli; Kathleen A Martin; Alex Toker; John Blenis
p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex.
Molecular and cellular biology 1999;19(4):2921-8.
1999: Anne Brunet; Azad Bonni; Michael Zigmond; Michael Z Lin; Peter Juo; Linda S Hu; Michael Anderson; K C Arden; John Blenis; Michael E Greenberg
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Cell 1999;96(6):857-68.
1999: Ivelisse Sanchez; C J Xu; Peter Juo; A Kakizaka; John Blenis; Junying Yuan
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
Neuron 1999;22(3):623-33.
1998: Peter Juo; CJ Kuo; Junying Yuan; John Blenis
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.
Current biology : CB 1998;8(18):1001-8.
1998: P B Joel; jeffrey smith; Thomas W Sturgill; T L Fisher; John Blenis; Deborah A Lannigan
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.
Molecular and cellular biology 1998;18(4):1978-84.
1997: K Schinkmann; John Blenis
Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.
The Journal of biological chemistry 1997;272(45):28695-703.
1997: J Chung; E Uchida; T C Grammer; John Blenis
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
Molecular and cellular biology 1997;17(11):6508-16.
1997: T C Grammer; John Blenis
Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases.
Oncogene 1997;14(14):1635-42.
1997: Mario Pende; T L Fisher; PB Simpson; James T Russell; John Blenis; Vittorio Gallo
Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(4):1291-301.
1997: R M Tung; John Blenis
A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase.
Oncogene 1997;14(6):653-9.
1997: Peter Juo; CJ Kuo; S E Reynolds; R F Konz; J Raingeaud; R J Davis; H P Biemann; John Blenis
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases.
Molecular and cellular biology 1997;17(1):24-35.
1996: K L Watson; M M Chou; John Blenis; William M Gelbart; Raymond L. Erikson
A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13694-8.
1996: T C Grammer; John Blenis
The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation.
The Journal of biological chemistry 1996;271(39):23650-2.
1996: M Monfar; John Blenis
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.
Molecular endocrinology (Baltimore, Md.) 1996;10(9):1107-15.
1996: T Nakajima; A Fukamizu; J Takahashi; F H Gage; T Fisher; John Blenis; M R Montminy
The signal-dependent coactivator CBP is a nuclear target for pp90RSK.
Cell 1996;86(3):465-74.
1996: Martin G Myers Jr; Y Zhang; G A Aldaz; T Grammer; E M Glasheen; Lynne Yenush; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.
Molecular and cellular biology 1996;16(8):4147-55.
1996: J Dahl; R Freund; John Blenis; Thomas L Benjamin
Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase.
Molecular and cellular biology 1996;16(6):2728-35.
1996: M M Chou; John Blenis
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.
Cell 1996;85(4):573-83.
1996: Lynne Yenush; R Fernandez; Martin G Myers Jr; T C Grammer; Xiao Jian Sun; John Blenis; J H Pierce; J Schlessinger; Morris F White
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.
Molecular and cellular biology 1996;16(5):2509-17.
1996: R H Chen; Peter Juo; T Curran; John Blenis
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity.
Oncogene 1996;12(7):1493-502.
1996: T L Fisher; John Blenis
Evidence for two catalytically active kinase domains in pp90rsk.
Molecular and cellular biology 1996;16(3):1212-9.
1996: T C Grammer; L Cheatham; M M Chou; John Blenis
The p70S6K signalling pathway: a novel signalling system involved in growth regulation.
Cancer surveys 1996;27():271-92.
1995: L Cheatham; M Monfar; M M Chou; John Blenis
Structural and functional analysis of pp70S6k.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11696-700.
1995: M M Chou; John Blenis
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling.
Current opinion in cell biology 1995;7(6):806-14.
1995: Francis J Dumont; Mary Jo Staruch; T Grammer; John Blenis; C A Kastner; Kathleen M Rupprecht
Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma.
Cellular immunology 1995;163(1):70-9.
1995: Martin G Myers Jr; T C Grammer; J Brooks; E M Glasheen; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
The Journal of biological chemistry 1995;270(20):11715-8.
1995: M Monfar; K P Lemon; T C Grammer; L Cheatham; J Chung; C J Vlahos; John Blenis
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.
Molecular and cellular biology 1995;15(1):326-37.
1994: Martin G Myers Jr; T C Grammer; L M Wang; Xiao Jian Sun; J H Pierce; John Blenis; Morris F White
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
The Journal of biological chemistry 1994;269(46):28783-9.
1994: J Chung; T C Grammer; K P Lemon; Andrius Kazlauskas; John Blenis
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.
Nature 1994;370(6484):71-5.
1994: Bentley Cheatham; C J Vlahos; L Cheatham; L Wang; John Blenis; C Ronald Kahn
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
Molecular and cellular biology 1994;14(7):4902-11.
1994: Francis J Dumont; A Altmeyer; C Kastner; P A Fischer; K P Lemon; J Chung; John Blenis; Mary Jo Staruch
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):992-1003.
1993: R H Chen; C Abate; John Blenis
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10952-6.
1993: John Blenis; Marilyn D Resh
Subcellular localization specified by protein acylation and phosphorylation.
Current opinion in cell biology 1993;5(6):984-9.
1993: R H Chen; R Tung; C Abate; John Blenis
Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase.
Biochemical Society transactions 1993;21(4):895-900.
1993: V M Rivera; Cindy Miranti; R P Misra; David D Ginty; R H Chen; John Blenis; Michael E Greenberg
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
Molecular and cellular biology 1993;13(10):6260-73.
1993: John Blenis
Signal transduction via the MAP kinases: proceed at your own RSK.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):5889-92.
1993: Diane C Fingar; S F Hausdorff; John Blenis; Morris J Birnbaum
Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.
The Journal of biological chemistry 1993;268(4):3005-8.
1992: C J Kuo; J Chung; D F Fiorentino; W M Flanagan; John Blenis; Gerald R Crabtree
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.
Nature 1992;358(6381):70-3.
1992: J Chung; C J Kuo; Gerald R Crabtree; John Blenis
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.
Cell 1992;69(7):1227-36.
1992: K W Wood; C Sarnecki; Thomas M Roberts; John Blenis
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK.
Cell 1992;68(6):1041-50.
1992: R H Chen; C Sarnecki; John Blenis
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
Molecular and cellular biology 1992;12(3):915-27.
1991: John Blenis
Growth-regulated signal transduction by the MAP kinases and RSKs.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(11):445-9.
1991: J Chung; S L Pelech; John Blenis
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4981-5.
1991: John Blenis; J Chung; E Erikson; D A Alcorta; Raymond L. Erikson
Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(6):279-85.
1991: R H Chen; J Chung; John Blenis
Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.
Molecular and cellular biology 1991;11(4):1861-7.
1991: J Chung; R H Chen; John Blenis
Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro.
Molecular and cellular biology 1991;11(4):1868-74.
1988: David A Talmage; John Blenis; Thomas L Benjamin
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways.
Molecular and cellular biology 1988;8(6):2309-15.
1988: S W Jones; E Erikson; John Blenis; J L Maller; Raymond L. Erikson
A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3377-81.
1988: Raymond L. Erikson; D Alcorta; P A Bedard; John Blenis; H P Biemann; E Erikson; S W Jones; J L Maller; T J Martins; D L Simmons
Molecular analyses of gene products associated with the response of cells to mitogenic stimulation.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():143-51.
1987: John Blenis; C J Kuo; Raymond L. Erikson
Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli.
The Journal of biological chemistry 1987;262(30):14373-6.
1987: John Blenis; C J Kuo; D A Alcorta; Raymond L. Erikson
Role of second messengers in regulating the growth-associated S6 protein kinase activity.
Progress in clinical and biological research 1987;249():181-92.