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Hing Sham

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Bowers Simeon; Probst Gary D; Truong Anh P; Hom Roy K; Konradi Andrei W; Sham Hing L; Garofalo Albert W; Wong Karina; Goldbach Erich; Quinn Kevin P; Sauer John-Michael; Wallace William; Nguyen Lan; Hemphill Susanna S; Bova Michael P; Basi Guriqbal S
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Truong Anh P; Aubele Danielle L; Probst Gary D; Neitzel Martin L; Semko Chris M; Bowers Simeon; Dressen Darren; Hom Roy K; Konradi Andrei W; Sham Hing L; Garofalo Albert W; Keim Pamela S; Wu Jing; Dappen Michael S; Wong Karina; Goldbach Erich; Quinn Kevin P; Sauer John-Michael; Brigham Elizabeth F; Wallace William; Nguyen Lan; Hemphill Susanna S; Bova Michael P; Basi Guriqbal
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Xin Zhili; Zhao Hongyu; Serby Michael D; Liu Bo; Liu Mei; Szczepankiewicz Bruce G; Nelson Lissa T J; Smith Harriet T; Suhar Tom S; Janis Rich S; Cao Ning; Camp Heidi S; Collins Christine A; Sham Hing L; Surowy Teresa K; Liu Gang
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.

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All Publications

2009: Bowers Simeon; Probst Gary D; Truong Anh P; Hom Roy K; Konradi Andrei W; Sham Hing L; Garofalo Albert W; Wong Karina; Goldbach Erich; Quinn Kevin P; Sauer John-Michael; Wallace William; Nguyen Lan; Hemphill Susanna S; Bova Michael P; Basi Guriqbal S
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorganic & medicinal chemistry letters 2009;19(24):6952-6.
2009: Truong Anh P; Aubele Danielle L; Probst Gary D; Neitzel Martin L; Semko Chris M; Bowers Simeon; Dressen Darren; Hom Roy K; Konradi Andrei W; Sham Hing L; Garofalo Albert W; Keim Pamela S; Wu Jing; Dappen Michael S; Wong Karina; Goldbach Erich; Quinn Kevin P; Sauer John-Michael; Brigham Elizabeth F; Wallace William; Nguyen Lan; Hemphill Susanna S; Bova Michael P; Basi Guriqbal
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(17):4920-3.
2008: Xin Zhili; Zhao Hongyu; Serby Michael D; Liu Bo; Liu Mei; Szczepankiewicz Bruce G; Nelson Lissa T J; Smith Harriet T; Suhar Tom S; Janis Rich S; Cao Ning; Camp Heidi S; Collins Christine A; Sham Hing L; Surowy Teresa K; Liu Gang
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(15):4298-302.
2008: Zhao Gang; Souers Andrew J; Voorbach Martin; Falls H Doug; Droz Brian; Brodjian Sevan; Lau Yau Yi; Iyengar Rajesh R; Gao Ju; Judd Andrew S; Wagaw Seble H; Ravn Matthew M; Engstrom Kenneth M; Lynch John K; Mulhern Mathew M; Freeman Jennifer; Dayton Brian D; Wang Xiaojun; Grihalde Nelson; Fry Dennis; Beno David W A; Marsh Kennan C; Su Zhi; Diaz Gilbert J; Collins Christine A; Sham Hing; Reilly Regina M; Brune Michael E; Kym Philip R
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
Journal of medicinal chemistry 2008;51(3):380-3.
2007: Tao Zhi-Fu; Li Gaoquan; Tong Yunsong; Stewart Kent D; Chen Zehan; Bui Mai-Ha; Merta Philip; Park Chang; Kovar Peter; Zhang Haiying; Sham Hing L; Rosenberg Saul H; Sowin Thomas J; Lin Nan-Horng
Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(21):5944-51.
2007: Tong Yunsong; Przytulinska Magdalena; Tao Zhi-Fu; Bouska Jennifer; Stewart Kent D; Park Chang; Li Gaoquan; Claiborne Akiyo; Kovar Peter; Chen Zehan; Merta Philip J; Bui Mai-Ha; Olson Amanda; Osterling Donald; Zhang Haiying; Sham Hing L; Rosenberg Saul H; Sowin Thomas J; Lin Nan-Horng
Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: improving oral biovailability.
Bioorganic & medicinal chemistry letters 2007;17(20):5665-70.
2007: Wang Le; Sullivan Gerard M; Hexamer Laura A; Hasvold Lisa A; Thalji Reema; Przytulinska Magdalena; Tao Zhi-Fu; Li Gaoquan; Chen Zehan; Xiao Zhan; Gu Wen-Zhen; Xue John; Bui Mai-Ha; Merta Philip; Kovar Peter; Bouska Jennifer J; Zhang Haiying; Park Chang; Stewart Kent D; Sham Hing L; Sowin Thomas J; Rosenberg Saul H; Lin Nan-Horng
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
Journal of medicinal chemistry 2007;50(17):4162-76.
2007: Tao Zhi-Fu; Li Gaoquan; Tong Yunsong; Chen Zehan; Merta Philip; Kovar Peter; Zhang Haiying; Rosenberg Saul H; Sham Hing L; Sowin Thomas J; Lin Nan-Horng
Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(15):4308-15.
2007: Tong Yunsong; Claiborne Akiyo; Pyzytulinska Magdalena; Tao Zhi-Fu; Stewart Kent D; Kovar Peter; Chen Zehan; Credo Robert B; Guan Ran; Merta Philip J; Zhang Haiying; Bouska Jennifer; Everitt Elizabeth A; Murry Bernard P; Hickman Dean; Stratton Tim J; Wu Jian; Rosenberg Saul H; Sham Hing L; Sowin Thomas J; Lin Nan-horng
1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: extended exploration on phenyl ring substitutions and preliminary ADME/PK studies.
Bioorganic & medicinal chemistry letters 2007;17(13):3618-23.
2007: Liu Gang; Lynch John K; Freeman Jennifer; Liu Bo; Xin Zhili; Zhao Hongyu; Serby Michael D; Kym Philip R; Suhar Tom S; Smith Harriet T; Cao Ning; Yang Ruojing; Janis Rich S; Krauser Joel A; Cepa Steven P; Beno David W A; Sham Hing L; Collins Christine A; Surowy Teresa K; Camp Heidi S
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
Journal of medicinal chemistry 2007;50(13):3086-100.
2007: Zhao Gang; Iyengar Rajesh R; Judd Andrew S; Cool Barbara; Chiou William; Kifle Lemma; Frevert Ernst; Sham Hing; Kym Philip R
Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.
Bioorganic & medicinal chemistry letters 2007;17(12):3254-7.
2007: Zhao Hongyu; Serby Michael D; Smith Harriet T; Cao Ning; Suhar Tom S; Surowy Teresa K; Camp Heidi S; Collins Christine A; Sham Hing L; Liu Gang
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(12):3388-91.
2007: Pei Zhonghua; Li Xiaofeng; von Geldern Thomas W; Longenecker Kenton; Pireh Daisy; Stewart Kent D; Backes Bradley J; Lai Chunqiu; Lubben Thomas H; Ballaron Stephen J; Beno David W A; Kempf-Grote Anita J; Sham Hing L; Trevillyan James M
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
Journal of medicinal chemistry 2007;50(8):1983-7.
2007: Judd Andrew S; Souers Andrew J; Wodka Dariusz; Zhao Gang; Mulhern Mathew M; Iyengar Rajesh R; Gao Ju; Lynch John K; Freeman Jennifer C; Falls H Douglas; Brodjian Sevan; Dayton Brian D; Reilly Regina M; Gintant Gary; Limberis James T; Mikhail Ann; Leitza Sandra T; Houseman Kathryn A; Diaz Gilbert; Bush Eugene N; Shapiro Robin; Knourek-Segel Victoria; Hernandez Lisa E; Marsh Kennan C; Sham Hing L; Collins Christine A; Kym Philip R
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
Bioorganic & medicinal chemistry letters 2007;17(8):2365-71.
2007: Tong Yunsong; Claiborne Akiyo; Stewart Kent D; Park Chang; Kovar Peter; Chen Zehan; Credo Robert B; Gu Wen-Zhen; Gwaltney Stephen L; Judge Russell A; Zhang Haiying; Rosenberg Saul H; Sham Hing L; Sowin Thomas J; Lin Nan-Horng
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorganic & medicinal chemistry 2007;15(7):2759-67.
2007: Backes Bradley J; Longenecker Kenton; Hamilton Gregory L; Stewart Kent; Lai Chunqiu; Kopecka Hana; von Geldern Thomas W; Madar David J; Pei Zhonghua; Lubben Thomas H; Zinker Bradley A; Tian Zhenping; Ballaron Stephen J; Stashko Michael A; Mika Amanda K; Beno David W A; Kempf-Grote Anita J; Black-Schaefer Candace; Sham Hing L; Trevillyan James M
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorganic & medicinal chemistry letters 2007;17(7):2005-12.
2007: Clark Richard F; Zhang Tianyuan; Wang Xiaojun; Wang Rongqi; Zhang Xiaolin; Camp Heidi S; Beutel Bruce A; Sham Hing L; Gu Yu Gui
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
Bioorganic & medicinal chemistry letters 2007;17(7):1961-5.
2007: Gu Yu Gui; Weitzberg Moshe; Clark Richard F; Xu Xiangdong; Li Qun; Lubbers Nathan L; Yang Yi; Beno David W A; Widomski Deborah L; Zhang Tianyuan; Hansen T Matthew; Keyes Robert F; Waring Jeffrey F; Carroll Sherry L; Wang Xiaojun; Wang Rongqi; Healan-Greenberg Christine H; Blomme Eric A; Beutel Bruce A; Sham Hing L; Camp Heidi S
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
Journal of medicinal chemistry 2007;50(5):1078-82.
2007: Xu Xiangdong; Weitzberg Moshe; Keyes Robert F; Li Qun; Wang Rongqi; Wang Xiaojun; Zhang Xiaolin; Frevert Ernst U; Camp Heidi S; Beutel Bruce A; Sham Hing L; Gu Yu Gui
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Bioorganic & medicinal chemistry letters 2007;17(6):1803-7.
2007: Iyengar Rajesh R; Lynch John K; Mulhern Mathew M; Judd Andrew S; Freeman Jennifer C; Gao Ju; Souers Andrew J; Zhao Gang; Wodka Dariusz; Doug Falls H; Brodjian Sevan; Dayton Brian D; Reilly Regina M; Swanson Sue; Su Zhi; Martin Ruth L; Leitza Sandra T; Houseman Kathryn A; Diaz Gilbert; Collins Christine A; Sham Hing L; Kym Philip R
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(4):874-8.
2007: Souers Andrew J; Iyengar Rajesh R; Judd Andrew S; Beno David W A; Gao Ju; Zhao Gang; Brune Michael E; Napier James J; Mulhern Mathew M; Lynch John K; Freeman Jennifer C; Wodka Dariusz; Chen Chong J; Falls H Doug; Brodjian Sevan; Dayton Brian D; Diaz Gilbert J; Bush Eugene N; Shapiro Robin; Droz Brian A; Knourek-Segel Victoria; Hernandez Lisa E; Marsh Kennan C; Reilly Regina M; Sham Hing L; Collins Christine A; Kym Philip R
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Bioorganic & medicinal chemistry letters 2007;17(4):884-9.
2007: Patel Jyoti R; Shuai Qi; Dinges Jurgen; Winn Marty; Pliushchev Marina; Fung Steven; Monzon Katina; Chiou William; Wang Jiahong; Pan Liping; Wagaw Seble; Engstrom Kenneth; Kerdesky Francis A; Longenecker Kenton; Judge Russell; Qin Wenying; Imade Hovis M; Stolarik Deanne; Beno David W A; Brune Michael; Chovan Linda E; Sham Hing L; Jacobson Peer; Link J T
Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2007;17(3):750-5.
2007: Liu Mei; Wang Sanyi; Clampit Jill E; Gum Rebecca J; Haasch Deanna L; Rondinone Cristina M; Trevillyan James M; Abad-Zapatero Cele; Fry Elizabeth H; Sham Hing L; Liu Gang
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Bioorganic & medicinal chemistry letters 2007;17(3):668-72.
2007: Rohde Jeffrey J; Pliushchev Marina A; Sorensen Bryan K; Wodka Dariusz; Shuai Qi; Wang Jiahong; Fung Steven; Monzon Katina M; Chiou William J; Pan Liping; Deng Xiaoqing; Chovan Linda E; Ramaiya Atul; Mullally Mark; Henry Rodger F; Stolarik DeAnne F; Imade Hovis M; Marsh Kennan C; Beno David W A; Fey Thomas A; Droz Brian A; Brune Michael E; Camp Heidi S; Sham Hing L; Frevert Ernst Uli; Jacobson Peer B; Link J T
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Journal of medicinal chemistry 2007;50(1):149-64.
2007: Liu Gang; Zhao Hongyu; Liu Bo; Xin Zhili; Liu Mei; Serby Michael D; Lubbers Nathan L; Widomski Deborah L; Polakowski James S; Beno David W A; Trevillyan James M; Sham Hing L
Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.
Bioorganic & medicinal chemistry letters 2007;17(2):495-500.
2006: Chen Zehan; Xiao Zhan; Gu Wen-Zhen; Xue John; Bui Mai H; Kovar Peter; Li Gaoquan; Wang Gary; Tao Zhi-Fu; Tong Yunsong; Lin Nan-Horng; Sham Hing L; Wang Jean Y J; Sowin Thomas J; Rosenberg Saul H; Zhang Haiying
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.
International journal of cancer. Journal international du cancer 2006;119(12):2784-94.
2006: Kurukulasuriya Ravi; Rohde Jeffrey J; Szczepankiewicz Bruce G; Basha Fatima; Lai Chunqui; Jae Hwan-Soo; Winn Martin; Stewart Kent D; Longenecker Kenton L; Lubben Thomas W; Ballaron Stephen J; Sham Hing L; von Geldern Thomas W
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(24):6226-30.
2006: Richards Steven; Sorensen Bryan; Jae Hwan-Soo; Winn Marty; Chen Yixian; Wang Jiahong; Fung Steven; Monzon Katina; Frevert Ernst U; Jacobson Peer; Sham Hing; Link J T
Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry letters 2006;16(24):6241-5.
2006: Clark Richard F; Zhang Tianyuan; Xin Zhili; Liu Gang; Wang Ying; Hansen T Matthew; Wang Xiaojun; Wang Rongqi; Zhang Xiaolin; Frevert Ernst U; Camp Heidi S; Beutel Bruce A; Sham Hing L; Gu Yu Gui
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Bioorganic & medicinal chemistry letters 2006;16(23):6078-81.
2006: Pei Zhonghua; Li Xiaofeng; von Geldern Thomas W; Madar David J; Longenecker Kenton; Yong Hong; Lubben Thomas H; Stewart Kent D; Zinker Bradley A; Backes Bradley J; Judd Andrew S; Mulhern Mathew; Ballaron Stephen J; Stashko Michael A; Mika Amanda K; Beno David W A; Reinhart Glenn A; Fryer Ryan M; Preusser Lee C; Kempf-Grote Anita J; Sham Hing L; Trevillyan James M
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(22):6439-42.
2006: Liu Gang; Zhao Hongyu; Liu Bo; Xin Zhili; Liu Mei; Kosogof Christi; Szczepankiewicz Bruce G; Wang Sanyi; Clampit Jill E; Gum Rebecca J; Haasch Deanna L; Trevillyan James M; Sham Hing L
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.
Bioorganic & medicinal chemistry letters 2006;16(22):5723-30.
2006: Yeh Vince S C; Patel Jyoti R; Yong Hong; Kurukulasuriya Ravi; Fung Steven; Monzon Katina; Chiou William; Wang Jiahong; Stolarik Deanne; Imade Hovis; Beno David; Brune Michael; Jacobson Peer; Sham Hing; Link J T
Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5414-9.
2006: Yeh Vince S C; Kurukulasuriya Ravi; Madar David; Patel Jyoti R; Fung Steven; Monzon Katina; Chiou William; Wang Jiahong; Jacobson Peer; Sham Hing L; Link J T
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
Bioorganic & medicinal chemistry letters 2006;16(20):5408-13.
2006: Xin Zhili; Serby Michael D; Zhao Hongyu; Kosogof Christi; Szczepankiewicz Bruce G; Liu Mei; Liu Bo; Hutchins Charles W; Sarris Kathy A; Hoff Ethan D; Falls H Douglas; Lin Chun W; Ogiela Christopher A; Collins Christine A; Brune Michael E; Bush Eugene N; Droz Brian A; Fey Thomas A; Knourek-Segel Victoria E; Shapiro Robin; Jacobson Peer B; Beno David W A; Turner Teresa M; Sham Hing L; Liu Gang
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
Journal of medicinal chemistry 2006;49(15):4459-69.
2006: Zhao Hongyu; Serby Michael D; Xin Zhili; Szczepankiewicz Bruce G; Liu Mei; Kosogof Christi; Liu Bo; Nelson Lissa T J; Johnson Eric F; Wang Sanyi; Pederson Terry; Gum Rebecca J; Clampit Jill E; Haasch Deanna L; Abad-Zapatero Cele; Fry Elizabeth H; Rondinone Cristina; Trevillyan James M; Sham Hing L; Liu Gang
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Journal of medicinal chemistry 2006;49(15):4455-8.
2006: Gu Yu Gui; Weitzberg Moshe; Clark Richard F; Xu Xiangdong; Li Qun; Zhang Tianyuan; Hansen T Matthew; Liu Gang; Xin Zhili; Wang Xiaojun; Wang Rongqi; McNally Teresa; Zinker Bradley A; Frevert Ernst U; Camp Heidi S; Beutel Bruce A; Sham Hing L
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
Journal of medicinal chemistry 2006;49(13):3770-3.
2006: Szczepankiewicz Bruce G; Kosogof Christi; Nelson Lissa T J; Liu Gang; Liu Bo; Zhao Hongyu; Serby Michael D; Xin Zhili; Liu Mei; Gum Rebecca J; Haasch Deanna L; Wang Sanyi; Clampit Jill E; Johnson Eric F; Lubben Thomas H; Stashko Michael A; Olejniczak Edward T; Sun Chaohong; Dorwin Sarah A; Haskins Kristi; Abad-Zapatero Cele; Fry Elizabeth H; Hutchins Charles W; Sham Hing L; Rondinone Cristina M; Trevillyan James M
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Journal of medicinal chemistry 2006;49(12):3563-80.
2006: Pei Zhonghua; Li Xiaofeng; Longenecker Kenton; von Geldern Thomas W; Wiedeman Paul E; Lubben Thomas H; Zinker Bradley A; Stewart Kent; Ballaron Stephen J; Stashko Michael A; Mika Amanda K; Beno David W A; Long Michelle; Wells Heidi; Kempf-Grote Anita J; Madar David J; McDermott Todd S; Bhagavatula Lakshmi; Fickes Michael G; Pireh Daisy; Solomon Larry R; Lake Marc R; Edalji Rohinton; Fry Elizabeth H; Sham Hing L; Trevillyan James M
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Journal of medicinal chemistry 2006;49(12):3520-35.
2006: Liu Mei; Xin Zhili; Clampit Jill E; Wang Sanyi; Gum Rebecca J; Haasch Deanna L; Trevillyan James M; Abad-Zapatero Cele; Fry Elizabeth H; Sham Hing L; Liu Gang
Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2590-4.
2006: Serby Michael D; Zhao Hongyu; Szczepankiewicz Bruce G; Kosogof Christi; Xin Zhili; Liu Bo; Liu Mei; Nelson Lissa T J; Kaszubska Wiweka; Falls H Douglas; Schaefer Verlyn; Bush Eugene N; Shapiro Robin; Droz Brian A; Knourek-Segel Victoria E; Fey Thomas A; Brune Michael E; Beno David W A; Turner Theresa M; Collins Christine A; Jacobson Peer B; Sham Hing L; Liu Gang
2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
Journal of medicinal chemistry 2006;49(8):2568-78.
2006: Kym Philip R; Souers Andrew J; Campbell Thomas J; Lynch John K; Judd Andrew S; Iyengar Rajesh; Vasudevan Anil; Gao Ju; Freeman Jennifer C; Wodka Dariusz; Mulhern Mathew; Zhao Gang; Wagaw Seble H; Napier James J; Brodjian Sevan; Dayton Brian D; Reilly Regina M; Segreti Jason A; Fryer Ryan M; Preusser Lee C; Reinhart Glenn A; Hernandez Lisa; Marsh Kennan C; Sham Hing L; Collins Christine A; Polakowski James S
Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.
Journal of medicinal chemistry 2006;49(7):2339-52.
2006: Li Gaoquan; Hasvold Lisa A; Tao Zhi-Fu; Wang Gary T; Gwaltney Stephen L; Patel Jyoti; Kovar Peter; Credo Robert B; Chen Zehan; Zhang Haiying; Park Chang; Sham Hing L; Sowin Thomas; Rosenberg Saul H; Lin Nan-Horng
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(8):2293-8.
2006: Liu Bo; Liu Mei; Xin Zhili; Zhao Hongyu; Serby Michael D; Kosogof Christi; Nelson Lissa T J; Szczepankiewicz Bruce G; Kaszubska Wiweka; Schaefer Verlyn G; Falls H Douglas; Lin Chun Wel; Collins Christine A; Sham Hing L; Liu Gang
Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration.
Bioorganic & medicinal chemistry letters 2006;16(7):1864-8.
2006: Lin Nan-Horng; Xia Ping; Kovar Peter; Park Chang; Chen Zehan; Zhang Haiying; Rosenberg Saul H; Sham Hing L
Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(2):421-6.
2005: Zhao Chen; Sham Hing L; Sun Minghua; Stoll Vincent S; Stewart Kent D; Lin Shuqun; Mo Hongmei; Vasavanonda Sudthida; Saldivar Ayda; Park Chang; McDonald Edith J; Marsh Kennan C; Klein Larry L; Kempf Dale J; Norbeck Daniel W
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Bioorganic & medicinal chemistry letters 2005;15(24):5499-503.
2005: Gu Wen-Zhen; Joseph Ingrid; Wang Yi-Chun; Frost David; Sullivan Gerard M; Wang Le; Lin Nan-Horng; Cohen Jerry; Stoll Vincent S; Jakob Clarissa G; Muchmore Steven W; Harlan John E; Holzman Tom; Walten Karl A; Ladror Uri S; Anderson Mark G; Kroeger Paul; Rodriguez Luis E; Jarvis Kenneth P; Ferguson Debra; Marsh Kennan; Ng Shichung; Rosenberg Saul H; Sham Hing L; Zhang Haiying
A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.
Anti-cancer drugs 2005;16(10):1059-69.
2005: Vasudevan Anil; LaMarche Matthew J; Blackburn Christopher; Che Jennifer Lee; Luchaco-Cullis Courtney A; Lai Sujen; Marsilje Thomas H; Patane Michael A; Souers Andrew J; Wodka Derek; Geddes Bradley; Chen Sumiao; Brodjian Seven; Falls Doug H; Dayton Brian D; Bush Eugene; Brune Michael; Shapiro Robin D; Marsh Kennan C; Hernandez Lisa E; Sham Hing L; Collins Christine A; Kym Philip R
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(19):4174-9.
2005: Maring Clarence J; Stoll Vincent S; Zhao Chen; Sun Minghua; Krueger Allan C; Stewart Kent D; Madigan Darold L; Kati Warren M; Xu Yibo; Carrick Robert J; Montgomery Debra A; Kempf-Grote Anita; Marsh Kennan C; Molla Akhteruzzaman; Steffy Kevin R; Sham Hing L; Laver W Graeme; Gu Yu-gui; Kempf Dale J; Kohlbrenner William E
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Journal of medicinal chemistry 2005;48(12):3980-90.
2005: Li Qun; Li Tongmei; Woods Keith W; Gu Wen-Zhen; Cohen Jerry; Stoll Vincent S; Galicia Tomas; Hutchins Charles; Frost David; Rosenberg Saul H; Sham Hing L
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
Bioorganic & medicinal chemistry letters 2005;15(11):2918-22.
2005: Souers Andrew J; Gao Ju; Wodka Dariusz; Judd Andrew S; Mulhern Mathew M; Napier James J; Brune Michael E; Bush Eugene N; Brodjian Sevan J; Dayton Brian D; Shapiro Robin; Hernandez Lisa E; Marsh Kennan C; Sham Hing L; Collins Christine A; Kym Philip R
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2005;15(11):2752-7.
2005: Wang Gary T; Li Gaoquan; Mantei Robert A; Chen Zehan; Kovar Peter; Gu Wendy; Xiao Zhan; Zhang Haiying; Sham Hing L; Sowin Thomas; Rosenberg Saul H; Lin Nan-Horng
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Journal of medicinal chemistry 2005;48(9):3118-21.
2005: Ferguson Debra; Rodriguez Luis E; Palma Joann P; Refici Marion; Jarvis Kenneth; O'Connor Jacqueline; Sullivan Gerard M; Frost David; Marsh Kennan; Bauch Joy; Zhang Haiying; Lin Nan-Horng; Rosenberg Saul; Sham Hing L; Joseph Ingrid B J K
Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):3045-54.
2005: Chen Zehan; Merta Philip J; Lin Nan-Hong; Tahir Stephen K; Kovar Peter; Sham Hing L; Zhang Haiying
A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth.
Molecular cancer therapeutics 2005;4(4):562-8.
2005: Li Qun; Woods Keith W; Wang Weibo; Lin Nan-Horng; Claiborne Akiyo; Gu Wen-zhen; Cohen Jerry; Stoll Vincent S; Hutchins Charles; Frost David; Rosenberg Saul H; Sham Hing L
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(8):2033-9.
2005: Zhao Hongyu; Xin Zhili; Patel Jyoti R; Nelson Lissa T J; Liu Bo; Szczepankiewicz Bruce G; Schaefer Verlyn G; Falls H Douglas; Kaszubska Wiweka; Collins Christine A; Sham Hing L; Liu Gang
Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(7):1825-8.
2005: Souers Andrew J; Gao Ju; Brune Michael; Bush Eugene; Wodka Dariusz; Vasudevan Anil; Judd Andrew S; Mulhern Mathew; Brodjian Sevan; Dayton Brian; Shapiro Robin; Hernandez Lisa E; Marsh Kennan C; Sham Hing L; Collins Christine A; Kym Philip R
Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
Journal of medicinal chemistry 2005;48(5):1318-21.
2005: Xin Zhili; Zhao Hongyu; Serby Michael D; Liu Bo; Schaefer Verlyn G; Falls Douglas H; Kaszubska Wiweka; Colins Christine A; Sham Hing L; Liu Gang
Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(4):1201-4.
2005: Wang Gary T; Wang Xilu; Wang Weibo; Hasvold Lisa A; Sullivan Gerry; Hutchins Charles W; O'Conner Steve; Gentiles Robert; Sowin Thomas; Cohen Jerry; Gu Wen-Zhen; Zhang Haiying; Rosenberg Saul H; Sham Hing L
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Bioorganic & medicinal chemistry letters 2005;15(1):153-8.
2004: Zhao Hongyu; Xin Zhili; Liu Gang; Schaefer Verlyn G; Falls H Douglas; Kaszubska Wiweka; Collins Christine A; Sham Hing L
Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation.
Journal of medicinal chemistry 2004;47(27):6655-7.
2004: Li Qun; Wang Gary T; Li Tongmei; Gwaltney Stephen L; Woods Keith W; Claiborne Akiyo; Wang Xilu; Gu Wendy; Cohen Jerry; Stoll Vincent S; Hutchins Charles; Frost David; Rosenberg Saul H; Sham Hing L
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5371-6.
2004: Li Qun; Claiborne Akiyo; Li Tongmei; Hasvold Lisa; Stoll Vincent S; Muchmore Steven; Jakob Clarissa G; Gu Wendy; Cohen Jerry; Hutchins Charles; Frost David; Rosenberg Saul H; Sham Hing L
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5367-70.
2004: Liu Bo; Liu Gang; Xin Zhili; Serby Micheal D; Zhao Hongyu; Schaefer Verlyn G; Falls H Douglas; Kaszubska Wiweka; Collins Christine A; Sham Hing L
Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(20):5223-6.
2004: Lin Nan-Horng; Wang Le; Wang Xilu; Wang Gary T; Cohen Jerry; Gu Wen-Zhen; Zhang Haiying; Rosenberg Saul H; Sham Hing L
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2004;14(20):5057-62.
2004: Kumar Gondi N; Jayanti Venkata K; Johnson Marianne K; Uchic John; Thomas Samuel; Lee Ronald D; Grabowski Brian A; Sham Hing L; Kempf Dale J; Denissen Jon F; Marsh Kennan C; Sun Eugene; Roberts Stanley A
Metabolism and disposition of the HIV-1 protease inhibitor lopinavir (ABT-378) given in combination with ritonavir in rats, dogs, and humans.
Pharmaceutical research 2004;21(9):1622-30.
2004: Wang Le; Lin Nan-Horng; Li Qun; Henry Rodger F; Zhang Haiying; Cohen Jerome; Gu Wen-Zhen; Marsh Kennan C; Bauch Joy L; Rosenberg Saul H; Sham Hing L
Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(18):4603-6.
2004: Segreti Jason A; Polakowski James S; Koch Kristin A; Marsh Kennan C; Bauch Joy L; Rosenberg Saul H; Sham Hing L; Cox Bryan F; Reinhart Glenn A
Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study.
Cancer chemotherapy and pharmacology 2004;54(3):273-81.
2004: Sham Hing L; Betebenner David A; Rosenbrook William; Herrin Thomas; Saldivar Ayda; Vasavanonda Sudthida; Plattner Jacob J; Norbeck Daniel W
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2004;14(10):2643-5.
2004: Wang Le; Wang Gary T; Wang Xilu; Tong Yunsong; Sullivan Gerry; Park David; Leonard Nicholas M; Li Qun; Cohen Jerry; Gu Wen-Zhen; Zhang Haiying; Bauch Joy L; Jakob Clarissa G; Hutchins Charles W; Stoll Vincent S; Marsh Kennan; Rosenberg Saul H; Sham Hing L; Lin Nan-Horng
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
Journal of medicinal chemistry 2004;47(3):612-26.
2003: Hasvold Lisa A; Wang Weibo; Gwaltney Stephen L; Rockway Todd W; Nelson Lissa T J; Mantei Robert A; Fakhoury Stephen A; Sullivan Gerard M; Li Qun; Lin Nan-Horng; Wang Le; Zhang Haiying; Cohen Jerome; Gu Wen-Zhen; Marsh Kennan; Bauch Joy; Rosenberg Saul; Sham Hing L
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2003;13(22):4001-5.
2003: Lin Nan-Horng; Wang Le; Cohen Jerry; Gu Wen-Zhen; Frost David; Zhang Haiying; Rosenberg Saul; Sham Hing
Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2003;13(21):3821-5.
2003: Chen Xiaoqi; Kempf Dale J; Li Lin; Sham Hing L; Vasavanonda Sudthida; Wideburg Norman E; Saldivar Ayda; Marsh Kennan C; McDonald Edith; Norbeck Daniel W
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.
Bioorganic & medicinal chemistry letters 2003;13(21):3657-60.
2003: Chen Zehan; Xiao Zhan; Chen Jun; Ng Shi-Chung; Sowin Thomas; Sham Hing; Rosenberg Saul; Fesik Steve; Zhang Haiying
Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.
Molecular cancer therapeutics 2003;2(6):543-8.
2003: Tong Yunsong; Lin Nan-Horng; Wang Le; Hasvold Lisa; Wang Weibo; Leonard Nicholas; Li Tongmei; Li Qun; Cohen Jerry; Gu Wen-Zhen; Zhang Haiying; Stoll Vincent; Bauch Joy; Marsh Kennan; Rosenberg Saul H; Sham Hing L
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorganic & medicinal chemistry letters 2003;13(9):1571-4.
2003: Curtin Michael L; Florjancic Alan S; Cohen Jerome; Gu Wen-Zhen; Frost David J; Muchmore Steven W; Sham Hing L
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Bioorganic & medicinal chemistry letters 2003;13(7):1367-71.
2003: Gwaltney Stephen L; O'Connor Stephen J; Nelson Lissa T J; Sullivan Gerard M; Imade Hovis; Wang Weibo; Hasvold Lisa; Li Qun; Cohen Jerome; Gu Wen-Zhen; Tahir Stephen K; Bauch Joy; Marsh Kennan; Ng Shi-Chung; Frost David J; Zhang Haiying; Muchmore Steve; Jakob Clarissa G; Stoll Vincent; Hutchins Charles; Rosenberg Saul H; Sham Hing L
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorganic & medicinal chemistry letters 2003;13(7):1363-6.
2003: Gwaltney Stephen L; O'Connor Stephen J; Nelson Lissa T J; Sullivan Gerard M; Imade Hovis; Wang Weibo; Hasvold Lisa; Li Qun; Cohen Jerome; Gu Wen-Zhen; Tahir Stephen K; Bauch Joy; Marsh Kennan; Ng Shi-Chung; Frost David J; Zhang Haiying; Muchmore Steve; Jakob Clarissa G; Stoll Vincent; Hutchins Charles; Rosenberg Saul H; Sham Hing L
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorganic & medicinal chemistry letters 2003;13(7):1359-62.
2003: Lin Nan-Horng; Wang Le; Cohen Jerry; Gu Wen-Zhen; Frost David; Zhang Haiying; Rosenberg Saul; Sham Hing
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2003;13(7):1293-6.
2003: Tahir Stephen K; Nukkala Michael A; Zielinski Mozny Nicolette A; Credo R Bruce; Warner Robert B; Li Qun; Woods Keith W; Claiborne Akiyo; Gwaltney Stephen L; Frost David J; Sham Hing L; Rosenberg Saul H; Ng Shi-Chung
Biological activity of A-289099: an orally active tubulin-binding indolyloxazoline derivative.
Molecular cancer therapeutics 2003;2(3):227-33.
2003: Stoll Vincent; Stewart Kent D; Maring Clarence J; Muchmore Steven; Giranda Vincent; Gu Yu-gui Y; Wang Gary; Chen Yuanwei; Sun Minghua; Zhao Chen; Kennedy April L; Madigan Darold L; Xu Yibo; Saldivar Ayda; Kati Warren; Laver Graeme; Sowin Thomas; Sham Hing L; Greer Jonathan; Kempf Dale
Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.
Biochemistry 2003;42(3):718-27.
2002: Sham Hing L; Zhao Chen; Li Leping; Betebenner David A; Saldivar Ayda; Vasavanonda Sudthida; Kempf Dale J; Plattner Jacob J; Norbeck Daniel W
Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(21):3101-3.
2002: Stoll Vincent; Qin Wenying; Stewart Kent D; Jakob Clarissa; Park Chang; Walter K; Simmer R L; Helfrich Rosalind; Bussiere Dirk; Kao J; Kempf Dale; Sham Hing L; Norbeck Daniel W
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease.
Bioorganic & medicinal chemistry 2002;10(8):2803-6.
2002: Sham Hing L; Betebenner David A; Chen Xiaoqi; Saldivar Ayda; Vasavanonda Sudthida; Kempf Dale J; Plattner Jacob J; Norbeck Daniel W
Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).
Bioorganic & medicinal chemistry letters 2002;12(8):1185-7.
2002: Wang Le; Woods Keith W; Li Qun; Barr Kenneth J; McCroskey Richard W; Hannick Steven M; Gherke Laura; Credo R Bruce; Hui Yu-Hua; Marsh Kennan; Warner Robert; Lee Jang Y; Zielinski-Mozng Nicolette; Frost David; Rosenberg Saul H; Sham Hing L
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Journal of medicinal chemistry 2002;45(8):1697-711.
2002: Li Qun; Woods Keith W; Claiborne Akiyo; Gwaltney Stephen L; Barr Kenneth J; Liu Gang; Gehrke Laura; Credo R Bruce; Hui Yu Hua; Lee Jang; Warner Robert B; Kovar Peter; Nukkala Michael A; Zielinski Nicolette A; Tahir Stephen K; Fitzgerald Michael; Kim Ki H; Marsh Kennan; Frost David; Ng Shi-Chung; Rosenberg Saul; Sham Hing L
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Bioorganic & medicinal chemistry letters 2002;12(3):465-9.
2001: Tahir S K; Han E K; Credo B; Jae H S; Pietenpol J A; Scatena C D; Wu-Wong J R; Frost D; Sham H; Rosenberg S H; Ng S C
A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.
Cancer research 2001;61(14):5480-5.
2001: Gwaltney S L; Imade H M; Li Q; Gehrke L; Credo R B; Warner R B; Lee J Y; Kovar P; Frost D; Ng S C; Sham H L
Novel sulfonate derivatives: potent antimitotic agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1671-3.
2001: Sham H L; Betebenner D A; Herrin T; Kumar G; Saldivar A; Vasavanonda S; Molla A; Kempf D J; Plattner J J; Norbeck D W
Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir).
Bioorganic & medicinal chemistry letters 2001;11(11):1351-3.
2001: Wang G T; Chen Y; Wang S; Gentles R; Sowin T; Kati W; Muchmore S; Giranda V; Stewart K; Sham H; Kempf D; Laver W G
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.
Journal of medicinal chemistry 2001;44(8):1192-201.
2001: Gwaltney S L; Imade H M; Barr K J; Li Q; Gehrke L; Credo R B; Warner R B; Lee J Y; Kovar P; Wang J; Nukkala M A; Zielinski N A; Frost D; Ng S C; Sham H L
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Bioorganic & medicinal chemistry letters 2001;11(7):871-4.
2000: Han E K; Gehrke L; Tahir S K; Credo R B; Cherian S P; Sham H; Rosenberg S H; Ng S
Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 2000;36(12):1565-71.
1999: Henry K J; Wasicak J; Tasker A S; Cohen J; Ewing P; Mitten M; Larsen J J; Kalvin D M; Swenson R; Ng S C; Saeed B; Cherian S; Sham H; Rosenberg S H
Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.
Journal of medicinal chemistry 1999;42(23):4844-52.
1999: O'Connor S J; Barr K J; Wang L; Sorensen B K; Tasker A S; Sham H; Ng S C; Cohen J; Devine E; Cherian S; Saeed B; Zhang H; Lee J Y; Warner R; Tahir S; Kovar P; Ewing P; Alder J; Mitten M; Leal J; Marsh K; Bauch J; Hoffman D J; Sebti S M; Rosenberg S H
Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy.
Journal of medicinal chemistry 1999;42(18):3701-10.
1999: Augeri D J; Janowick D; Kalvin D; Sullivan G; Larsen J; Dickman D; Ding H; Cohen J; Lee J; Warner R; Kovar P; Cherian S; Saeed B; Zhang H; Tahir S; Ng S C; Sham H; Rosenberg S H
Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase.
Bioorganic & medicinal chemistry letters 1999;9(8):1069-74.
1999: Shen W; Fakhoury S; Donner G; Henry K; Lee J; Zhang H; Cohen J; Warner R; Saeed B; Cherian S; Tahir S; Kovar P; Bauch J; Ng S C; Marsh K; Sham H; Rosenberg S
Potent inhibitors of protein farnesyltransferase: heteroarenes as cysteine replacements.
Bioorganic & medicinal chemistry letters 1999;9(5):703-8.
1999: Kati W M; Sham H L; McCall J O; Montgomery D A; Wang G T; Rosenbrook W; Miesbauer L; Buko A; Norbeck D W
Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides.
Archives of biochemistry and biophysics 1999;362(2):363-75.
1999: Kumar G N; Jayanti V; Lee R D; Whittern D N; Uchic J; Thomas S; Johnson P; Grabowski B; Sham H; Betebenner D; Kempf D J; Denissen J F
In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):86-91.
1998: Chen X; Kempf D J; Sham H L; Green B E; Molla A; Korneyeva M; Vasavanonda S; Wideburg N E; Saldivar A; Marsh K C; McDonald E; Norbeck D W
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.
Bioorganic & medicinal chemistry letters 1998;8(24):3531-6.
1998: Sham H L; Kempf D J; Molla A; Marsh K C; Kumar G N; Chen C M; Kati W; Stewart K; Lal R; Hsu A; Betebenner D; Korneyeva M; Vasavanonda S; McDonald E; Saldivar A; Wideburg N; Chen X; Niu P; Park C; Jayanti V; Grabowski B; Granneman G R; Sun E; Japour A J; Leonard J M; Plattner J J; Norbeck D W
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.
Antimicrobial agents and chemotherapy 1998;42(12):3218-24.
1998: Molla A; Vasavanonda S; Kumar G; Sham H L; Johnson M; Grabowski B; Denissen J F; Kohlbrenner W; Plattner J J; Leonard J M; Norbeck D W; Kempf D J
Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus.
Virology 1998;250(2):255-62.
1998: Carrillo A; Stewart K D; Sham H L; Norbeck D W; Kohlbrenner W E; Leonard J M; Kempf D J; Molla A
In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor.
Journal of virology 1998;72(9):7532-41.
1998: Kati W M; Saldivar A S; Mohamadi F; Sham H L; Laver W G; Kohlbrenner W E
GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains.
Biochemical and biophysical research communications 1998;244(2):408-13.
1998: Kempf D J; Sham H L; Marsh K C; Flentge C A; Betebenner D; Green B E; McDonald E; Vasavanonda S; Saldivar A; Wideburg N E; Kati W M; Ruiz L; Zhao C; Fino L; Patterson J; Molla A; Plattner J J; Norbeck D W
Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.
Journal of medicinal chemistry 1998;41(4):602-17.
1996: Sham H L; Zhao C; Marsh K C; Betebenner D A; Lin S; Rosenbrook W; Herrin T; Li L; Madigan D; Vasavanonda S; Molla A; Saldivar A; McDonald E; Wideburg N E; Kempf D; Norbeck D W; Plattner J J
Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.
Biochemical and biophysical research communications 1996;225(2):436-40.
1996: Sham H L; Zhao C; Stewart K D; Betebenner D A; Lin S; Park C H; Kong X P; Rosenbrook W; Herrin T; Madigan D; Vasavanonda S; Lyons N; Molla A; Saldivar A; Marsh K C; McDonald E; Wideburg N E; Denissen J F; Robins T; Kempf D J; Plattner J J; Norbeck D W
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Journal of medicinal chemistry 1996;39(2):392-7.
1995: Sham H L; Zhao C; Marsh K C; Betebenner D A; Lin S; McDonald E; Vasavanonda S; Wideburg N; Saldivar A; Robins T
Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.
Biochemical and biophysical research communications 1995;211(1):159-65.
1994: Kempf D J; Marsh K C; Fino L C; Bryant P; Craig-Kennard A; Sham H L; Zhao C; Vasavanonda S; Kohlbrenner W E; Wideburg N E
Design of orally bioavailable, symmetry-based inhibitors of HIV protease.
Bioorganic & medicinal chemistry 1994;2(9):847-58.
1993: Sham H L; Betebenner D A; Wideburg N; Saldivar A C; Kohlbrenner W E; Craig-Kennard A; Vasavanonda S; Kempf D J; Clement J J; Erickson J E
Pseudo-symmetrical difluoroketones. Highly potent and specific inhibitors of HIV-1 protease.
FEBS letters 1993;329(1-2):144-6.
1993: Kempf D J; Codacovi L; Wang X C; Kohlbrenner W E; Wideburg N E; Saldivar A; Vasavanonda S; Marsh K C; Bryant P; Sham H L
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.
Journal of medicinal chemistry 1993;36(3):320-30.
1991: Sham H L; Betebenner D A; Wideburg N E; Saldivar A C; Kohlbrenner W E; Vasavanonda S; Kempf D J; Norbeck D W; Zhao C; Clement J J
Potent HIV-1 protease inhibitors with antiviral activities in vitro.
Biochemical and biophysical research communications 1991;175(3):914-9.
1990: Rosenberg S H; Woods K W; Sham H L; Kleinert H D; Martin D L; Stein H; Cohen J; Egan D A; Bopp B; Merits I
Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.
Journal of medicinal chemistry 1990;33(7):1962-9.
1990: Norbeck D W; Kern E; Hayashi S; Rosenbrook W; Sham H; Herrin T; Plattner J J; Erickson J; Clement J; Swanson R
Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
Journal of medicinal chemistry 1990;33(5):1281-5.
1988: Plattner J J; Marcotte P A; Kleinert H D; Stein H H; Greer J; Bolis G; Fung A K; Bopp B A; Luly J R; Sham H L
Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.
Journal of medicinal chemistry 1988;31(12):2277-88.
1988: Sham H L; Bolis G; Stein H H; Fesik S W; Marcotte P A; Plattner J J; Rempel C A; Greer J
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.
Journal of medicinal chemistry 1988;31(2):284-95.
1987: Sham H L; Stein H; Rempel C A; Cohen J; Plattner J J
Highly potent and specific inhibitors of human renin.
FEBS letters 1987;220(2):299-301.
1987: Fesik S W; Bolis G; Sham H L; Olejniczak E T
Structure refinement of a cyclic peptide from two-dimensional NMR data and molecular modeling.
Biochemistry 1987;26(7):1851-9.
1986: Plattner J J; Greer J; Fung A K; Stein H; Kleinert H D; Sham H L; Smital J R; Perun T J
Peptide analogues of angiotensinogen. Effect of peptide chain length on renin inhibition.
Biochemical and biophysical research communications 1986;139(3):982-90.

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