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Alykhan Shamji

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Physiology

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Saccharomyces cerevisiae

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Publications

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Drew J Adams; Zarko V Boskovic; Alykhan F Shamji; Andrew M Stern; Jimmy R Theriault; Bridget K Wagner; Alex J Wang; Stuart L Schreiber
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.
Drew J Adams; Mingji Dai; Giovanni Pellegrino; Alykhan F Shamji; Andrew M Stern; Bridget K Wagner; Stuart L Schreiber
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.
Yuan Yuan; Alykhan F Shamji; Bridget K Wagner; Qiu Wang; Drew J Adams; Melissa M Kemp; Stefan Kubicek; Joshiawa Paulk; Stuart L Schreiber
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.

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All Publications

2013: Drew J Adams; Zarko V Boskovic; Alykhan F Shamji; Andrew M Stern; Jimmy R Theriault; Bridget K Wagner; Alex J Wang; Stuart L Schreiber
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.
ACS chemical biology 2013;8(5):923-9.
2012: Drew J Adams; Mingji Dai; Giovanni Pellegrino; Alykhan F Shamji; Andrew M Stern; Bridget K Wagner; Stuart L Schreiber
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15115-20.
2012: Yuan Yuan; Alykhan F Shamji; Bridget K Wagner; Qiu Wang; Drew J Adams; Melissa M Kemp; Stefan Kubicek; Joshiawa Paulk; Stuart L Schreiber
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.
ACS chemical biology 2012;7(7):1152-7.
2012: Stefan Kubicek; Timothy A Lewis; Tuoping Luo; Paul A Clemons; Dina Fomina-Yadlin; Joshua C Gilbert; Alexander D Gitlin; Supriya Gupta; Edward B Holson; Alykhan F Shamji; Bradley Taylor; Bridget K Wagner; Florence F Wagner; Yuan Yuan; Stuart L Schreiber
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5364-9.
2012: Deepika Walpita; Paul A Clemons; Nathalie Fiaschi-Taesch; Dina Fomina-Yadlin; Thomas Hasaka; Stuart L Schreiber; Alykhan F Shamji; James Spoonamore; Andrew F Stewart; Karen K Takane; Amedeo Vetere; Bridget K Wagner
A human islet cell culture system for high-throughput screening.
Journal of biomolecular screening 2012;17(4):509-18.
2010: Paul A Clemons; Nicole E Bodycombe; Hyman A Carrinski; J Anthony Wilson; Alykhan F Shamji; Bridget K Wagner; Angela N Koehler; Stuart L Schreiber
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18787-92.
2004: Emily Humphrey-Dixon; Alykhan F Shamji; Bradley E Bernstein; Stuart L Schreiber
Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.
Chemistry & biology 2004;11(3):295-9.
2003: Alykhan F Shamji; Paul X Nghiem; Stuart L Schreiber
Integration of growth factor and nutrient signaling: implications for cancer biology.
Molecular cell 2003;12(2):271-80.
2003: Angela N Koehler; Alykhan F Shamji; Stuart L Schreiber
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.
Journal of the American Chemical Society 2003;125(28):8420-1.
2002: Finny G Kuruvilla; Alykhan F Shamji; Scott M Sternson; Paul J Hergenrother; Stuart L Schreiber
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.
Nature 2002;416(6881):653-7.
2001: Finny G Kuruvilla; Alykhan F Shamji; Stuart L Schreiber
Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7283-8.
2000: Alykhan F Shamji; Finny G Kuruvilla; Stuart L Schreiber
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins.
Current biology : CB 2000;10(24):1574-81.
1999: J S Hardwick; Finny G Kuruvilla; J K Tong; Alykhan F Shamji; Stuart L Schreiber
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14866-70.