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Kevin Shannon

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Catherine Hartzell; Richard C Harvey; Olga Ksionda; Ed Lemmens; Tineke L Lenstra; Mignon Loh; Kristin Ammon; Jeroen Bakker; Anne Boeter; Arup K Chakraborty; Kristen Coakley; Monique Dail; Christopher Govern; Kevin Shannon; Matthias Wabl; Stuart S Winter; Ming Yang; Jeroen P Roose
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Tiffany Chang; Scott Kogan; Kimberly Krisman; Jennifer O Lauchle; Jon Akutagawa; Benjamin S Braun; Emily Harding Theobald; Jin Xu; Kevin Shannon
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
Neil P Shah; Kevin Shannon
Advancing the STATus of MPN pathogenesis.

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All Publications

2013: Catherine Hartzell; Richard C Harvey; Olga Ksionda; Ed Lemmens; Tineke L Lenstra; Mignon Loh; Kristin Ammon; Jeroen Bakker; Anne Boeter; Arup K Chakraborty; Kristen Coakley; Monique Dail; Christopher Govern; Kevin Shannon; Matthias Wabl; Stuart S Winter; Ming Yang; Jeroen P Roose
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Science signaling 2013;6(268):ra21.
2013: Tiffany Chang; Scott Kogan; Kimberly Krisman; Jennifer O Lauchle; Jon Akutagawa; Benjamin S Braun; Emily Harding Theobald; Jin Xu; Kevin Shannon
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation 2013;123(1):335-9.
2012: Neil P Shah; Kevin Shannon
Advancing the STATus of MPN pathogenesis.
Blood 2012;119(15):3374-6.
2012: Jin Xu; Herbert Waldmann; Frank J Dekker; Kevin M Haigis; Christian Hedberg; Eugene Hwang; Qing Li; Kevin Shannon
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.
Blood 2012;119(4):1032-5.
2011: Natalya Lyubynska; Matthew F Gorman; Jennifer O Lauchle; Wan Xing Hong; Jon K Akutagawa; Kevin Shannon; Benjamin S Braun
A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice.
Science translational medicine 2011;3(76):76ra27.
2011: Qing Li; Kevin M Haigis; Andrew McDaniel; Emily Harding-Theobald; Scott C Kogan; Keiko Akagi; Jasmine C Y Wong; Benjamin S Braun; Linda Wolff; Tyler Jacks; Kevin Shannon
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
Blood 2011;117(6):2022-32.
2011: Jean Lee Nakamura; Connie Phong; Emile Pinarbasi; Scott C Kogan; Scott Vandenberg; Andrew E Horvai; Bruce A Faddegon; Dorothea Fiedler; Kevan Shokat; Benjamin T Houseman; Richard Chao; Russell O Pieper; Kevin Shannon
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
Cancer research 2011;71(1):106-15.
2010: Jamil Aboulhosn; Ryan Williams; Kalyanam Shivkumar; Rakhi Barkowski; Mark Plunkett; Pamela Miner; Linda Houser; Hillel Laks; Brian Reemtsen; Kevin Shannon; John Child
Arrhythmia recurrence in adult patients with single ventricle physiology following surgical Fontan conversion.
Congenital heart disease 2010;5(5):430-4.
2010: David Buchbinder; Daniel S Levi; Alan Ikeda; Kevin Shannon; Theodore Moore
Inappropriate sinus tachycardia after hematopoietic stem cell transplantation.
Journal of pediatric hematology/oncology 2010;32(1):15-8.
2009: Jennifer O Lauchle; Doris Kim; Doan T Le; Keiko Akagi; Michael Crone; Kimberly Krisman; Kegan Warner; Jeannette M Bonifas; Qing Li; Kristen M Coakley; Ernesto Diaz-Flores; Matthew Gorman; Sally Przybranowski; Mary Tran; Scott C Kogan; Jeroen P Roose; Neal G Copeland; Nancy A Jenkins; Luis F Parada; Linda Wolff; Judith Leopold; Kevin Shannon
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Nature 2009;461(7262):411-4.
2009: Mignon L Loh; Debbie S Sakai; Christian Flotho; Michelle Kang; Manfred Fliegauf; Sophie Archambeault; Charles G Mullighan; Leslie Chen; Eva Bergstraesser; Carlos E Bueso-Ramos; Peter D Emanuel; Henrik Hasle; Jean-Pierre J Issa; Marry M van den Heuvel-Eibrink; Franco Locatelli; Jan Stary; Monika M Trebo; Marcin Wlodarski; Marco Zecca; Kevin Shannon; Charlotte M Niemeyer
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Blood 2009;114(9):1859-63.
2009: Kevin Shannon; Mignon L Loh
Cancer: More than kin and less than kind.
Nature 2009;460(7257):804-7.
2009: Benjamin S Braun; Kevin Shannon
The SPS affair: a complex tale of illicit proliferation.
Cancer cell 2009;16(2):87-8.
2009: Amit J Sabnis; Laurene S Cheung; Monique Dail; Hio Chung Kang; Marianne Santaguida; Michelle L Hermston; Emmanuelle Passegué; Kevin Shannon; Benjamin S Braun
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
PLoS biology 2009;7(3):e59.
2009: Yan Zhang; Jasmine Wong; Mark Klinger; Mary T Tran; Kevin Shannon; Nigel Killeen
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
Blood 2009;113(7):1455-63.
2009: Bin Yin; Ruud Delwel; Peter J Valk; Margaret R Wallace; Mignon L Loh; Kevin Shannon; David Largaespada
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
Blood 2009;113(5):1075-85.
2009: Oddmund Søvik; Solrun J Steine; Bernt Engelsen; Gunnar Houge; Pål R Njølstad; Gunnar Norgård; Suzanne Schubbert; Kevin Shannon; Anders Molven
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.
BMJ case reports 2009;2009():.
2008: Jasmine C Wong; Michelle M Le Beau; Kevin Shannon
Tumor suppressor gene inactivation in myeloid malignancies.
Best practice & research. Clinical haematology 2008;21(4):601-14.
2008: Nikesh Kotecha; Nikki J Flores; Jonathan Irish; Erin F Simonds; Debbie S Sakai; Sophie Archambeault; Ernesto Diaz-Flores; Marc Coram; Kevin Shannon; Garry P Nolan; Mignon L Loh
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Cancer cell 2008;14(4):335-43.
2008: Kevin Haigis; Krystle R Kendall; Yufang Wang; Ann Cheung; Marcia C Haigis; Jonathan N Glickman; Michiko Niwa-Kawakita; Eric A. Sweet-Cordero; Judith Leopold; Kevin Shannon; Jeffrey Settleman; Marco Giovannini; Tyler Jacks
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Nature genetics 2008;40(5):600-8.
2008: Benjamin S Braun; Kevin Shannon
Targeting Ras in myeloid leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2249-52.
2008: Beverly J Lange; Franklin O Smith; James Feusner; Dorothy R Barnard; Patricia A Dinndorf; Stephen Feig; Nyla A Heerema; Carola Arndt; Robert J Arceci; Nita L Seibel; Margie Weiman; Kathryn E Dusenbery; Kevin Shannon; Sandra Luna-Fineman; Robert B Gerbing; Todd A Alonzo
Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children's oncology group.
Blood 2008;111(3):1044-53.
2008: Ellen Denayer; Annabel Parret; Magdalena Chmara; Suzanne Schubbert; Annick Vogels; koenraad devriendt; JP Frijns; Vladimir Rybin; T J L de Ravel; Kevin Shannon; Jan Cools; Klaus Scheffzek; Eric Legius
Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.
Human mutation 2008;29(2):232-9.
2008: Kevin Shannon; Michelle M Le Beau
Cancer: hay in a haystack.
Nature 2008;451(7176):252-3.
2007: Suzanne Schubbert; Gideon Bollag; Natalya Lyubynska; Hoa Nguyen; Christian P Kratz; Martin Zenker; Charlotte M Niemeyer; Anders Molven; Kevin Shannon
Biochemical and functional characterization of germ line KRAS mutations.
Molecular and cellular biology 2007;27(22):7765-70.
2007: Ernesto Diaz-Flores; Kevin Shannon
Targeting oncogenic Ras.
Genes & development 2007;21(16):1989-92.
2007: Oddmund Søvik; Suzanne Schubbert; Gunnar Houge; Solrun J Steine; Gunnar Norgård; Bernt Engelsen; Pål R Njølstad; Kevin Shannon; Anders Molven
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.
Journal of medical genetics 2007;44(7):e84.
2007: Yi Zhang; Ernesto Diaz-Flores; Geqiang Li; Zhengqi Wang; Zizhen Kang; Eleonora Haviernikova; Sara Rowe; Cheng-Kui Qu; William Tse; Kevin Shannon; Kevin D Bunting
Abnormal hematopoiesis in Gab2 mutant mice.
Blood 2007;110(1):116-24.
2007: Margaret E M Van Meter; Ernesto Díaz-Flores; Joehleen A Archard; Emmanuelle Passegué; Jonathan Irish; Nikesh Kotecha; Garry P Nolan; Kevin Shannon; Benjamin S Braun
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Blood 2007;109(9):3945-52.
2007: Suzanne Schubbert; Kevin Shannon; Gideon Bollag
Hyperactive Ras in developmental disorders and cancer.
Nature reviews. Cancer 2007;7(4):295-308.
2007: Andrew Kim; Kelly Morgan; Diane E Hasz; Stephen M Wiesner; Jennifer O Lauchle; Jennifer L Geurts; Miechaleen D Diers; Doan T Le; Scott C Kogan; Luis F Parada; Kevin Shannon; David Largaespada
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Blood 2007;109(4):1687-91.
2007: Suzanne Schubbert; Gideon Bollag; Kevin Shannon
Deregulated Ras signaling in developmental disorders: new tricks for an old dog.
Current opinion in genetics & development 2007;17(1):15-22.
2007: Kevin Shannon; Gideon Bollag
Sending out an SOS.
Nature genetics 2007;39(1):8-9.
2006: Benjamin S Braun; Joehleen A Archard; Jessica Van Ziffle; David A Tuveson; Tyler Jacks; Kevin Shannon
Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
Blood 2006;108(6):2041-4.
2006: Karen Stephens; Molly Weaver; Kathleen A Leppig; Kyoko Maruyama; Peter D Emanuel; Michelle M Le Beau; Kevin Shannon
Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies.
Blood 2006;108(5):1684-9.
2006: Christian P Kratz; Suzanne Schubbert; Gideon Bollag; Charlotte M Niemeyer; Kevin Shannon; Martin Zenker
Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders.
Cell cycle (Georgetown, Tex.) 2006;5(15):1607-11.
2006: Mignon L Loh; Meredith A Goldwasser; Lewis B Silverman; Wing-Man Poon; Shashaank Vattikuti; Angelo A Cardoso; Donna Neuberg; Kevin Shannon; Stephen E Sallan; D Gary Gilliland
Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01.
Blood 2006;107(11):4508-13.
2006: Jennifer O Lauchle; Benjamin S Braun; Mignon L Loh; Kevin Shannon
Inherited predispositions and hyperactive Ras in myeloid leukemogenesis.
Pediatric blood & cancer 2006;46(5):579-85.
2006: David H Gutmann; Kim Hunter-Schaedle; Kevin Shannon
Harnessing preclinical mouse models to inform human clinical cancer trials.
The Journal of clinical investigation 2006;116(4):847-52.
2006: Suzanne Schubbert; Martin Zenker; Sara L Rowe; Silke Böll; Cornelia Klein; Gideon Bollag; Ineke van der Burgt; Luciana Musante; Vera Kalscheuer; Lars-Erik Wehner; Hoa Nguyen; Brian West; Kam Y J Zhang; Erik A Sistermans; Anita Rauch; Charlotte M Niemeyer; Kevin Shannon; Christian P Kratz
Germline KRAS mutations cause Noonan syndrome.
Nature genetics 2006;38(3):331-6.
2005: Richard C Chao; Urszula Pyzel; Jane Fridlyand; Yien-Ming Kuo; Lewis Teel; Jennifer Haaga; Alexander D Borowsky; Andrew Horvai; Scott C Kogan; Jeannette Bonifas; Bing Huey; Tyler Jacks; Donna G Albertson; Kevin Shannon
Therapy-induced malignant neoplasms in Nf1 mutant mice.
Cancer cell 2005;8(4):337-48.
2005: Robert J Arceci; Jane Sande; Beverly Lange; Kevin Shannon; Janet Franklin; Raymond J Hutchinson; Terry A Vik; David A Flowers; Richard Aplenc; Mark S Berger; Matthew L Sherman; Franklin O Smith; Irwin D Bernstein; Eric L Sievers
Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia.
Blood 2005;106(4):1183-8.
2005: Suzanne Schubbert; Kenneth Lieuw; Sara L Rowe; Connie M Lee; Xiaxin Li; Mignon L Loh; D Wade Clapp; Kevin Shannon
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.
Blood 2005;106(1):311-7.
2005: Nicole P Curtiss; Jeannette Bonifas; Jennifer O Lauchle; Jason D Balkman; Christian P Kratz; Brooke M Emerling; Eric Green; Michelle M Le Beau; Kevin Shannon
Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.
Genomics 2005;85(5):600-7.
2005: Kevin Shannon; Richard A Van Etten
JAKing up hematopoietic proliferation.
Cancer cell 2005;7(4):291-3.
2005: Manuela Germeshausen; Harald Schulze; C Kratz; Ludwig Wilkens; R Repp; Kevin Shannon; Karl Welte; Matthias Ballmaier
An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia.
Leukemia 2005;19(4):611-7.
2005: Tamiko R Katsumoto; Jennifer L.H. Duda; Andrew Kim; Zabihullah Wardak; Glenn Dranoff; D Wade Clapp; Kevin Shannon
Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells.
The Journal of experimental medicine 2005;201(6):853-8.
2004: Richard A Van Etten; Kevin Shannon
Focus on myeloproliferative diseases and myelodysplastic syndromes.
Cancer cell 2004;6(6):547-52.
2004: Doan T Le; Namie Kong; Yuan Zhu; Jennifer O Lauchle; Abigail Aiyigari; Benjamin S Braun; Endi Wang; Scott C Kogan; Michelle M Le Beau; Luis F Parada; Kevin Shannon
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
Blood 2004;103(11):4243-50.
2004: Mignon L Loh; Shashaank Vattikuti; Suzanne Schubbert; Melissa G Reynolds; Elaine Carlson; Kenneth Lieuw; Jennifer W Cheng; Connie M Lee; David Stokoe; Jeannette Bonifas; Nicole P Curtiss; Jason Gotlib; Soheil Meshinchi; Michelle M Le Beau; Peter D Emanuel; Kevin Shannon
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
Blood 2004;103(6):2325-31.
2004: Benjamin S Braun; Kevin Shannon
The sum is greater than the FGFR1 partner.
Cancer cell 2004;5(3):203-4.
2004: Lucy E Side; Nicole P Curtiss; Kathryn Teel; Christian P Kratz; Pauline W Wang; Richard A Larson; Michelle M Le Beau; Kevin Shannon
RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of chromosomes 5 and 7.
Genes, chromosomes & cancer 2004;39(3):217-23.
2004: Benjamin S Braun; David A Tuveson; Namie Kong; Doan T Le; Scott C Kogan; Jacob Rozmus; Michelle M Le Beau; Tyler Jacks; Kevin Shannon
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):597-602.
2004: Marco Tartaglia; Charlotte M Niemeyer; Kevin Shannon; Mignon L Loh
SHP-2 and myeloid malignancies.
Current opinion in hematology 2004;11(1):44-50.
2003: Christian P Kratz; Letizia Antonietti; Kevin Shannon; Mukund G Dole; Sarah E Friebert
Acute myeloid leukemia associated with t(8;21) or trisomy 8 in children with neurofibromatosis, type 1.
Journal of pediatric hematology/oncology 2003;25(4):343.
2003: Abigail L Aiyagari; Brigit R Taylor; Vikas Aurora; Stephen G Young; Kevin Shannon
Hematologic effects of inactivating the Ras processing enzyme Rce1.
Blood 2003;101(6):2250-2.
2003: David A Ingram; Mary Jo Wenning; Kevin Shannon; D Wade Clapp
Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.
Blood 2003;101(5):1984-6.
2003: Brian Weiss; Kevin Shannon
Mouse cancer models as a platform for performing preclinical therapeutic trials.
Current opinion in genetics & development 2003;13(1):84-9.
2002: Shane Donovan; Wendy See; Jeannette Bonifas; David Stokoe; Kevin Shannon
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells.
Cancer cell 2002;2(6):507-14.
2002: James R Downing; Kevin Shannon
Acute leukemia: a pediatric perspective.
Cancer cell 2002;2(6):437-45.
2002: Peter J Houghton; Peter Charles Adamson; Susan Blaney; Howard A Fine; Richard Gorlick; Michelle Haber; Lee Helman; Steve Hirschfeld; Melinda G Hollingshead; Mark Israel; Richard B Lock; John M Maris; Glenn Merlino; Wendy Patterson; Charles Patrick Reynolds; Kevin Shannon; Alice L Yu; John Yu; Malcolm A Smith
Testing of new agents in childhood cancer preclinical models: meeting summary.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3646-57.
2002: Kevin Shannon
Resistance in the land of molecular cancer therapeutics.
Cancer cell 2002;2(2):99-102.
2002: Brooke M Emerling; Jeannette Bonifas; Christian P Kratz; Shane Donovan; Brigit R Taylor; Eric Green; Michelle M Le Beau; Kevin Shannon
MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.
Oncogene 2002;21(31):4849-54.
2002: Yigal Dror; Peter Roy Durie; Hedy H Ginzberg; Rebecca Herman; Anu Banerjee; Martin Champagne; Kevin Shannon; David Malkin; Melvin H Freedman
Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study.
Experimental hematology 2002;30(7):659-69.
2002: Doan Thuy Le; Kevin Shannon
Ras processing as a therapeutic target in hematologic malignancies.
Current opinion in hematology 2002;9(4):308-15.
2002: Shane Donovan; Kevin Shannon; Gideon Bollag
GTPase activating proteins: critical regulators of intracellular signaling.
Biochimica et biophysica acta 2002;1602(1):23-45.
2002: Christian P Kratz; Brooke M Emerling; Jeannette Bonifas; Winfred Wang; Eric Green; Michelle M Le Beau; Kevin Shannon
Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor.
Blood 2002;99(1):372-4.
2001: Anuradha Banerjee; Kevin Shannon
Leukemic transformation in patients with severe congenital neutropenia.
Journal of pediatric hematology/oncology 2001;23(8):487-95.
2001: Christian P Kratz; Brooke M Emerling; Shane Donovan; M Laig-Webster; Brigit R Taylor; P Thompson; S Jensen; A Banerjee; Jeannette Bonifas; W Makalowski; Eric Green; Michelle M Le Beau; Kevin Shannon
Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Genomics 2001;77(3):171-80.
2001: Y Zhang; B R Taylor; Kevin Shannon; D W Clapp
Quantitative effects of Nf1 inactivation on in vivo hematopoiesis.
The Journal of clinical investigation 2001;108(5):709-15.
2001: Kevin Shannon; M M Le Beau; David Largaespada; N Killeen
Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse.
Seminars in cancer biology 2001;11(3):191-200.
2000: L J Cooper; Kevin Shannon; Michael R Loken; Molly Weaver; Karen Stephens; Eric L Sievers
Evidence that juvenile myelomonocytic leukemia can arise from a pluripotential stem cell.
Blood 2000;96(6):2310-3.
2000: David A Ingram; Feng-Chun Yang; Jeff Travers; Mary Jo Wenning; Kelly K Hiatt; S New; Antoinette F Hood; Kevin Shannon; David A Williams; D Wade Clapp
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.
The Journal of experimental medicine 2000;191(1):181-8.
2000: R A Birnbaum; AS O'Marcaigh; Zabihullah Wardak; Y Y Zhang; Glenn Dranoff; Tyler Jacks; D Wade Clapp; Kevin Shannon
Nf1 and Gmcsf interact in myeloid leukemogenesis.
Molecular cell 2000;5(1):189-95.
1999: N Mahgoub; Brigit R Taylor; M Gratiot; Nancy E Kohl; Jackson B Gibbs; Tyler Jacks; Kevin Shannon
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells.
Blood 1999;94(7):2469-76.
1999: E Mantadakis; Kevin Shannon; D A Singer; Jerry Z Finklestein; Ka Wah Chan; J M Hilden; Eric S Sandler
Transient monosomy 7: a case series in children and review of the literature.
Cancer 1999;85(12):2655-61.
1999: N Mahgoub; Brigit R Taylor; Michelle M Le Beau; M Gratiot; K M Carlson; SK Atwater; Tyler Jacks; Kevin Shannon
Myeloid malignancies induced by alkylating agents in Nf1 mice.
Blood 1999;93(11):3617-23.
1999: B Weiss; Gideon Bollag; Kevin Shannon
Hyperactive Ras as a therapeutic target in neurofibromatosis type 1.
American journal of medical genetics 1999;89(1):14-22.
1999: Edward Kim; Patricia Ambroziak; James C Otto; B Taylor; M Ashby; Kevin Shannon; Patrick J Casey; Stephen G Young
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
The Journal of biological chemistry 1999;274(13):8383-90.
1999: M C Fernandez; B Weiss; S Atwater; Kevin Shannon; Katherine K Matthay
Congenital leukemia: successful treatment of a newborn with t(5;11)(q31;q23).
Journal of pediatric hematology/oncology 1999;21(2):152-7.
1999: S Luna-Fineman; Kevin Shannon; SK Atwater; J Davis; Margaret Masterson; J Ortega; J Sanders; Peter G Steinherz; V Weinberg; Beverly J Lange
Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients.
Blood 1999;93(2):459-66.
1998: Lucy E Side; Peter D Emanuel; B Taylor; J Franklin; P Thompson; Robert P Castleberry; Kevin Shannon
Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.
Blood 1998;92(1):267-72.
1998: Kevin Shannon
Genetic predispositions and childhood cancer.
Environmental health perspectives 1998;106 Suppl 3():801-6.
1998: Y Y Zhang; TA Vik; JW Ryder; Edward F Srour; Tyler Jacks; Kevin Shannon; D Wade Clapp
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.
The Journal of experimental medicine 1998;187(11):1893-902.
1998: R W Frenck; Elizabeth H Blackburn; Kevin Shannon
The rate of telomere sequence loss in human leukocytes varies with age.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5607-10.
1998: N Mahgoub; Robert Ingalls Parker; MR Hosler; P Close; Naomi J Winick; Margaret Masterson; Kevin Shannon; Carolyn A Felix
RAS mutations in pediatric leukemias with MLL gene rearrangements.
Genes, chromosomes & cancer 1998;21(3):270-5.
1997: AS O'Marcaigh; Kevin Shannon
Role of the NF1 gene in leukemogenesis and myeloid growth control.
Journal of pediatric hematology/oncology 1997;19(6):551-4.
1997: Lucy E Side; B Taylor; MC Cayouette; ER Conner; P Thompson; M Luce; Kevin Shannon
Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders.
The New England journal of medicine 1997;336(24):1713-20.
1997: Lucy E Side; Kevin Shannon
Myeloid disorders in infants with Noonan syndrome and a resident's "rule" recalled.
The Journal of pediatrics 1997;130(6):857-9.
1997: John M Maris; S R Wiersma; N Mahgoub; P Thompson; R J Geyer; C G Hurwitz; Beverly J Lange; Kevin Shannon
Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.
Cancer 1997;79(7):1438-46.
1996: Gideon Bollag; F Adler; N elMasry; P C McCabe; E Conner; P Thompson; F McCormick; Kevin Shannon
Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.
The Journal of biological chemistry 1996;271(51):32491-4.
1996: D K Miles; M H Freedman; K Stephens; Maria G Pallavicini; E L Sievers; M Weaver; T Grunberger; P Thompson; Kevin Shannon
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.
Blood 1996;88(11):4314-20.
1996: Peter D Emanuel; Kevin Shannon; R P Castleberry
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy.
Molecular medicine today 1996;2(11):468-75.
1996: David H Gutmann; James G Gurney; Kevin Shannon
Juvenile xanthogranuloma, neurofibromatosis 1, and juvenile chronic myeloid leukemia.
Archives of dermatology 1996;132(11):1390-1.
1996: Gideon Bollag; D W Clapp; S Shih; F Adler; Y Y Zhang; P Thompson; B J Lange; M H Freedman; F McCormick; T Jacks; Kevin Shannon
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells.
Nature genetics 1996;12(2):144-8.
1995: R Kalra; D Dale; M Freedman; M A Bonilla; M Weinblatt; Arnold Ganser; P Bowman; S Abish; J Priest; R S Oseas; K Olson; D Paderanga; Kevin Shannon
Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia.
Blood 1995;86(12):4579-86.
1995: Kevin Shannon
Recombinant human erythropoietin in neonatal anemia.
Clinics in perinatology 1995;22(3):627-40.
1995: S Jensen; D C Paderanga; P Chen; K Olson; M Edwards; A Iavorone; Mark Israel; Kevin Shannon
Molecular analysis at the NF1 locus in astrocytic brain tumors.
Cancer 1995;76(4):674-7.
1995: Kevin Shannon
The Ras signaling pathway and the molecular basis of myeloid leukemogenesis.
Current opinion in hematology 1995;2(4):305-8.
1995: S Luna-Fineman; Kevin Shannon; Beverly J Lange
Childhood monosomy 7: epidemiology, biology, and mechanistic implications.
Blood 1995;85(8):1985-99.
1995: Kevin Shannon; J F Keith; W C Mentzer; R A Ehrenkranz; M S Brown; J A Widness; C A Gleason; E M Bifano; D D Millard; C B Davis
Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants.
Pediatrics 1995;95(1):1-8.
1995: M Butcher; R Frenck; J Emperor; D Paderanga; D Maybee; K Olson; Kevin Shannon
Molecular evidence that childhood monosomy 7 syndrome is distinct from juvenile chronic myelogenous leukemia and other childhood myeloproliferative disorders.
Genes, chromosomes & cancer 1995;12(1):50-7.
1994: R Kalra; D C Paderanga; K Olson; Kevin Shannon
Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras.
Blood 1994;84(10):3435-9.
1994: R C Lau; Jeremy Squire; L Brisson; Suzanne Kamel-Reid; T Grunberger; Ian D Dubé; Michelle Letarte; Kevin Shannon; Melvin H Freedman
Lymphoid blast crisis of B-lineage phenotype with monosomy 7 in a patient with juvenile chronic myelogenous leukemia (JCML).
Leukemia 1994;8(5):903-8.
1994: Kevin Shannon; P O'Connell; George Martin; D Paderanga; K Olson; P Dinndorf; F McCormick
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders.
The New England journal of medicine 1994;330(9):597-601.
1994: P Savage; R Frenck; D Paderanga; J Emperor; Kevin Shannon
Parental origins of chromosome 7 loss in childhood monosomy 7 syndrome.
Leukemia 1994;8(3):485-9.
1993: Kevin Shannon
Recombinant erythropoietin in anemia of prematurity: five years later.
Pediatrics 1993;92(4):614-7.
1993: H Kobayashi; Rafael Espinosa; M J Thirman; A A Fernald; Kevin Shannon; Manuel O Diaz; Michelle M Le Beau; Janet D Rowley
Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization.
Genes, chromosomes & cancer 1993;7(4):204-8.
1993: R W Frenck; Kevin Shannon
Hematopoietic growth factors in pediatrics.
Current opinion in pediatrics 1993;5(1):94-102.
1992: Kevin Shannon; A G Turhan; P C Rogers; Y W Kan
Evidence implicating heterozygous deletion of chromosome 7 in the pathogenesis of familial leukemia associated with monosomy 7.
Genomics 1992;14(1):121-5.
1992: Kevin Shannon
Genetic alterations in leukemia: events on a grand scale.
Blood 1992;80(1):1-2.
1992: Kevin Shannon; W C Mentzer; R I Abels; M Wertz; J Thayer-Moriyama; W Y Li; D Thompson; S Decelle; Roderic H Phibbs
Enhancement of erythropoiesis by recombinant human erythropoietin in low birth weight infants: a pilot study.
The Journal of pediatrics 1992;120(4 Pt 1):586-92.
1992: Kevin Shannon; J Watterson; P Johnson; P O'Connell; B Lange; N Shah; Peter G Steinherz; Y W Kan; J R Priest
Monosomy 7 myeloproliferative disease in children with neurofibromatosis, type 1: epidemiology and molecular analysis.
Blood 1992;79(5):1311-8.
1992: Roderic H Phibbs; Kevin Shannon; W C Mentzer
Potential for treatment of anaemia of prematurity with recombinant human erythropoietin: preliminary results.
Acta haematologica 1992;87 Suppl 1():28-33.
1991: Kevin Shannon; W C Mentzer; R I Abels; P Freeman; N Newton; D Thompson; S Sniderman; R Ballard; Roderic H Phibbs
Recombinant human erythropoietin in the anemia of prematurity: results of a placebo-controlled pilot study.
The Journal of pediatrics 1991;118(6):949-55.
1991: A Neubauer; Kevin Shannon; E Liu
Mutations of the ras proto-oncogenes in childhood monosomy 7.
Blood 1991;77(3):594-8.
1991: W C Mentzer; Kevin Shannon; R I Abels; P Freeman; N Newton; D Thompson; Roderic H Phibbs
A randomized, placebo-controlled clinical trial of recombinant human erythropoietin in the anemia of prematurity.
Contributions to nephrology 1991;88():306-12; discussion 313.
1990: J W George; C A Bracco; Kevin Shannon; G J Davis; I L Smith; Roderic H Phibbs; Andrew G Hendrickx
Age-related differences in erythropoietic response to recombinant human erythropoietin: comparison in adult and infant rhesus monkeys.
Pediatric research 1990;28(6):567-71.
1990: Kevin Shannon; D B Ring; L L Houston; V Schaffner; J Naylor; J C Torkildson; S A Reid; J Larrick
Inhibition of hematopoietic progenitor colony growth by a monoclonal antibody against the transferrin receptor: comparison of unconjugated antibody with an immunotoxin containing recombinant ricin A chain.
International journal of cell cloning 1990;8(5):368-76.
1990: Kevin Shannon
Recombinant erythropoietin in pediatrics: a clinical perspective.
Pediatric annals 1990;19(3):197-206.
1990: Kevin Shannon
Anemia of prematurity: progress and prospects.
The American journal of pediatric hematology/oncology 1990;12(1):14-20.
1990: Kevin Shannon; W Koehne; M B Heyman; M A Koerper
Relapsing post-hepatitis aplastic anemia. Immunosuppressive therapy.
Clinical pediatrics 1990;29(1):25-9.
1989: Kevin Shannon; A G Turhan; S S Chang; A M Bowcock; P C Rogers; W L Carroll; M J Cowan; B E Glader; C J Eaves; A C Eaves
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7.
The Journal of clinical investigation 1989;84(3):984-9.
1989: Roderic H Phibbs; Kevin Shannon; W C Mentzer
Rationale for using recombinant human erythropoietin to treat the anemia of prematurity.
Contributions to nephrology 1989;76():324-8; discussion 328-9.
1989: Kevin Shannon; G K Clemons; J C Torkildson; G R Buchanan; W C Mentzer
Spontaneous resolution of primary erythrocytosis in two girls.
Pediatric hematology and oncology 1989;6(4):373-82.
1988: Morton J Cowan; Kevin Shannon; D W Wara; A J Ammann
Rejection of bone marrow transplant and resistance of alloantigen reactive cells to in vivo deoxyadenosine in adenosine deaminase deficiency.
Clinical immunology and immunopathology 1988;49(2):242-50.
1987: Kevin Shannon; G S Naylor; J C Torkildson; G K Clemons; V Schaffner; S L Goldman; K Lewis; P Bryant; Roderic H Phibbs
Circulating erythroid progenitors in the anemia of prematurity.
The New England journal of medicine 1987;317(12):728-33.
1987: D E Hogge; Kevin Shannon; D K Kalousek; S Schonberg; V Schaffner; S Zoger; C J Eaves; A C Eaves
Juvenile monosomy 7 syndrome: evidence that the disease originates in a pluripotent hemopoietic stem cell.
Leukemia research 1987;11(8):705-9.
1986: Kevin Shannon; J W Larrick; S A Fulcher; K B Burck; J Pacely; J C Davis; D B Ring
Selective inhibition of the growth of human erythroid bursts by monoclonal antibodies against transferrin or the transferrin receptor.
Blood 1986;67(6):1631-8.
1986: Kevin Shannon; Gabriel Nunez; L W Dow; A G Weinberg; Y Sato; P Stastny; G R Buchanan
Juvenile chronic myelogenous leukemia: surface antigen phenotyping by monoclonal antibodies and cytogenetic studies.
Pediatrics 1986;77(3):330-5.
1985: Kevin Shannon; M J Cowan; E Ball; D Abrams; P Volberding; A J Ammann
Impaired mononuclear-cell proliferation in patients with the acquired immune deficiency syndrome results from abnormalities of both T lymphocytes and adherent mononuclear cells.
Journal of clinical immunology 1985;5(4):239-45.
1984: Kevin Shannon; G R Buchanan; C W Fink; P Stastny
Lymphocyte populations in childhood idiopathic thrombocytopenic purpura.
American journal of diseases of children (1960) 1984;138(1):64-5.
1983: Kevin Shannon; E Ball; R L Wasserman; F K Murphy; J Luby; G R Buchanan
Transfusion-associated cytomegalovirus infection and acquired immune deficiency syndrome in an infant.
The Journal of pediatrics 1983;103(6):859-63.
1983: Kevin Shannon; C W Fink; G R Buchanan; M Punaro; P Stastny
Lymphocyte subpopulations in Kawasaki disease.
Clinical and experimental rheumatology 1983;1(1):59-62.
1982: Kevin Shannon; G R Buchanan
Severe hemolytic anemia in black children with glucose-6-phosphate dehydrogenase deficiency.
Pediatrics 1982;70(3):364-9.
1982: Kevin Shannon; G R Buchanan; T P Votteler
Multiple hepatic hemangiomas: failure of corticosteroid therapy and successful hepatic artery ligation.
American journal of diseases of children (1960) 1982;136(3):275-6.