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Najam Sharif

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Najam A Sharif; Julie Y Crider
Human choroidal melanocyte signal transduction responses to various pharmacological agents: focus on endothelin receptors.
Najam A Sharif; Julie Y Crider
Intracellular signaling in human iridial fibroblasts and iridial melanocytes in response to prostaglandins, endothelin, isoproterenol, and other pharmacological agents.
Charanya Ramachandran; Rajkumar V Patil; Najam A Sharif; Sangly P Srinivas
Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells.

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All Publications

2011: Najam A Sharif; Julie Y Crider
Human choroidal melanocyte signal transduction responses to various pharmacological agents: focus on endothelin receptors.
Current eye research 2011;36(5):462-8.
2011: Najam A Sharif; Julie Y Crider
Intracellular signaling in human iridial fibroblasts and iridial melanocytes in response to prostaglandins, endothelin, isoproterenol, and other pharmacological agents.
Current eye research 2011;36(4):310-20.
2011: Charanya Ramachandran; Rajkumar V Patil; Najam A Sharif; Sangly P Srinivas
Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells.
Investigative ophthalmology & visual science 2011;52(3):1474-85.
2010: Dorette Z Ellis; Najam A Sharif; William M Dismuke
Endogenous regulation of human Schlemm's canal cell volume by nitric oxide signaling.
Investigative ophthalmology & visual science 2010;51(11):5817-24.
2010: Najam A Sharif
Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action.
Current drug targets 2010;11(8):978-93.
2010: Robert Faulkner; Najam A Sharif; Susan Orr; Kenneth Sall; Harvey Dubiner; Jess T Whitson; Marlene Moster; E Randy Craven; Michael Curtis; Cynthia Pailliotet; Kimberly Martens; David Dahlin
Aqueous humor concentrations of bimatoprost free acid, bimatoprost and travoprost free acid in cataract surgical patients administered multiple topical ocular doses of LUMIGAN or TRAVATAN.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2010;26(2):147-56.
2010: Najam A Sharif; Terry K Wiernas
Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2010;26(1):21-9.
2010: Parvaneh Katoli; Najam A Sharif; Anupam Sule; Slobodan D Dimitrijevich
NPR-B natriuretic peptide receptors in human corneal epithelium: mRNA, immunohistochemistochemical, protein, and biochemical pharmacology studies.
Molecular vision 2010;16():1241-52.
2010: Adnan Dibas; Hidehiro Oku; Masayuki Fukuhara; Takuji Kurimoto; Tsunehiko Ikeda; Rajkumar V Patil; Najam A Sharif; Thomas Yorio
Changes in ocular aquaporin expression following optic nerve crush.
Molecular vision 2010;16():330-40.
2009: William M Dismuke; Najam A Sharif; Dorette Z Ellis
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Investigative ophthalmology & visual science 2009;50(7):3353-9.
2009: Najam A Sharif; Marsha A McLaughlin; Curtis R Kelly; Parvaneh Katoli; Colene Drace; Shahid Husain; Craig E Crosson; Carol Toris; Gui-Lin Zhan; Carl Camras
Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes.
Experimental eye research 2009;88(3):386-97.
2009: Zixia Feng; Mark R Hellberg; Najam A Sharif; Marsha A McLaughlin; Gary W Williams; Daniel Scott; Tony Wallace
Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.
Bioorganic & medicinal chemistry 2009;17(2):576-84.
2009: Najam A Sharif; Shouxi Xu; Peggy E Hellberg; Iok-Hou Pang; Daniel A Gamache; John M Yanni
Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines.
Molecular vision 2009;15():1153-61.
2008: Najam A Sharif; Ismail Kaddour-Djebbar; Ata A Abdel-Latif
Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2008;24(2):152-63.
2008: Najam A Sharif
Synthetic FP-prostaglandin-induced contraction of rat uterus smooth muscle in vitro.
Prostaglandins, leukotrienes, and essential fatty acids 2008;78(3):199-207.
2007: Zixia Feng; Suchismita Mohapatra; Peter G Klimko; Mark R Hellberg; Jesse A May; Curtis Kelly; Gary Williams; Marsha A McLaughlin; Najam A Sharif
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Bioorganic & medicinal chemistry letters 2007;17(11):2998-3002.
2007: Najam A Sharif; Marsha A McLaughlin; Curtis R Kelly
AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(1):1-13.
2006: Najam A Sharif; Curtis R Kelly; Julie Y Crider; Terry L Davis
Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2006;22(6):389-401.
2006: Najam A Sharif; Marsha A McLaughlin; Curtis R Kelly; Shouxi Xu; Julie Y Crider; Gary W Williams; Janet L Parker
Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2006;22(5):291-309.
2006: Najam A Sharif; Curtis R Kelly; Marsha McLaughlin
Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction.
Investigative ophthalmology & visual science 2006;47(9):4001-10.
2006: Curtis R Kelly; Najam A Sharif
Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1254-61.
2006: Jesse A May; Anura P Dantanarayana; Paul W Zinke; Marsha A McLaughlin; Najam A Sharif
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Journal of medicinal chemistry 2006;49(1):318-28.
2006: Najam A Sharif; Michelle Senchyna
Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR.
Molecular vision 2006;12():1040-7.
2005: Najam A Sharif; Terry L Davis; Gary W Williams
Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005;21(2):121-32.
2004: Najam A Sharif; Gary W Williams; Julie Y Crider; Shouxi X Xu; Terry L Davis
Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2004;20(6):489-508.
2004: Richard A Glennon; Mikhail L Bondarev; Nantaka Khorana; Richard Young; Jesse A May; Mark R Hellberg; Marsha A McLaughlin; Najam A Sharif
Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Journal of medicinal chemistry 2004;47(24):6034-41.
2004: Najam A Sharif; Colene D Drace; Gary W Williams; Julie Y Crider
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation.
The Journal of pharmacy and pharmacology 2004;56(10):1267-74.
2004: Robert D Selliah; Mark R Hellberg; Najam A Sharif; Marsha A McLaughlin; Gary W Williams; Daniel A Scott; David Earnest; Karen Haggard; W Dennis Dean; Pete Delgado; Michael S Gaines; Raymond E Conrow; Peter G Klimko
AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.
Bioorganic & medicinal chemistry letters 2004;14(17):4525-8.
2004: Peter G Klimko; Mark R Hellberg; Marsha McLaughlin; Najam A Sharif; Bryon Severns; Gary Williams; Karen Haggard; John Liao
15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives.
Bioorganic & medicinal chemistry 2004;12(13):3451-69.
2004: Najam A Sharif; S X Xu
Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates.
The Journal of pharmacy and pharmacology 2004;56(2):197-203.
2003: Sunny E Ohia; Sunday O Awe; Catherine A Opere; Angela M LeDay; Lydia C Harris; Kaustubh H Kulkarni; Najam A Sharif
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2003;19(6):599-609.
2003: Najam A Sharif; Curtis R Kelly; Julie Y Crider; Gary W Williams; Shouxi X Xu
Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2003;19(6):501-15.
2003: Julie Y Crider; Gary W Williams; Colene D Drace; Parvaneh Katoli; Michelle Senchyna; Najam A Sharif
Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells.
Investigative ophthalmology & visual science 2003;44(11):4837-44.
2003: Najam A Sharif; Julie Y Crider; Shahid Husain; Ismail Kaddour-Djebbar; Habib R Ansari; Ata A Abdel-Latif
Human ciliary muscle cell responses to FP-class prostaglandin analogs: phosphoinositide hydrolysis, intracellular Ca2+ mobilization and MAP kinase activation.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2003;19(5):437-55.
2003: Jesse A May; Hwang-Hsing Chen; Andrew Rusinko; Vincent M Lynch; Najam A Sharif; Marsha A McLaughlin
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Journal of medicinal chemistry 2003;46(19):4188-95.
2003: Jesse A May; Marsha A McLaughlin; Najam A Sharif; Mark R Hellberg; Tom R Dean
Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys.
The Journal of pharmacology and experimental therapeutics 2003;306(1):301-9.
2003: Najam A Sharif; Curtis R Kelly; Julie Y Crider
Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues.
Investigative ophthalmology & visual science 2003;44(2):715-21.
2003: Najam A Sharif; Curtis R Kelly; Gary W Williams
Bimatoprost (Lumigan((R))) is an agonist at the cloned human ocular FP prostaglandin receptor: real-time FLIPR-based intracellular Ca(2+) mobilization studies.
Prostaglandins, leukotrienes, and essential fatty acids 2003;68(1):27-33.
2003: Curtis R Kelly; Gary W Williams; Najam A Sharif
Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.
The Journal of pharmacology and experimental therapeutics 2003;304(1):238-45.
2002: Lydia C Harris; Sunday O Awe; Catherine A Opere; Angela M LeDay; Sunny E Ohia; Najam A Sharif
Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(4):339-48.
2002: Najam A Sharif; Curtis R Kelly; Julie Y Crider
Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(4):313-24.
2002: Mark R Hellberg; Marsha A McLaughlin; Najam A Sharif; Louis DeSantis; Tom R Dean; Evan P Kyba; John E Bishop; Peter G Klimko; Paul W Zinke; Robert D Selliah; George Barnes; Joseph DeFaller; Angela Kothe; Theresa A Landry; E Kenneth Sullivan; Russell Andrew; Alberta A Davis; Lewis Silver; Michael V W Bergamini; Stella Robertson; Alan L Weiner; Verney L Sallee
Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.
Survey of ophthalmology 2002;47 Suppl 1():S13-33.
2002: Julie Y Crider; Najam A Sharif
Adenylyl cyclase activity mediated by beta-adrenoceptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(3):221-30.
2002: Mark R Hellberg; Raymond E Conrow; Najam A Sharif; Marsha A McLaughlin; John E Bishop; Julie Y Crider; W Dennis Dean; Kevin A DeWolf; David R Pierce; Verney L Sallee; Robert D Selliah; Bryon S Severns; Steven J Sproull; Gary W Williams; Paul W Zinke; Peter G Klimko
3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.
Bioorganic & medicinal chemistry 2002;10(6):2031-49.
2002: Najam A Sharif; Michelle Senchyna; S X Xu
Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(2):141-62.
2002: Najam A Sharif; Terry L Davis
Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques.
The Journal of pharmacy and pharmacology 2002;54(4):539-47.
2001: Najam A Sharif; Gary W Williams; Curtis R Kelly
Bimatoprost and its free acid are prostaglandin FP receptor agonists.
European journal of pharmacology 2001;432(2-3):211-3.
2001: Julie Y Crider; Shouxi X Xu; Najam A Sharif
Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: comparison with binding data from human platelets.
Prostaglandins, leukotrienes, and essential fatty acids 2001;65(5-6):253-8.
2001: Sunny E Ohia; O S Awe; Catherine A Opere; Angela M LeDay; Lydia C Harris; Najam A Sharif
Hypoxia-induced [(3)H]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists.
Current eye research 2001;23(5):386-92.
2001: Mark R Hellberg; Verney L Sallee; Marsha A McLaughlin; Najam A Sharif; L Desantis; Tom R Dean; Paul W Zinke
Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(5):421-32.
2001: Jagadeesh B Rangisetty; Malgorzata Dukat; C S Dowd; Katharine Herrick-Davis; A DuPre; S Gadepalli; Milt Teitler; C R Kelley; Najam A Sharif; Richard A Glennon
1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.
Journal of medicinal chemistry 2001;44(20):3283-91.
2001: Najam A Sharif; Shouxi X Xu; Julie Y Crider; M McLaughlin; Terry L Davis
Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(4):305-17.
2001: Lydia C Harris; Sunday O Awe; Catherine A Opere; Angela M LeDay; Sunny E Ohia; Najam A Sharif
[(3)H]-serotonin release from bovine iris-ciliary body: pharmacology of prejunctional serotonin (5-HT(7)) autoreceptors.
Experimental eye research 2001;73(1):59-67.
2001: Julie Y Crider; Najam A Sharif
Functional pharmacological evidence for EP2 and EP4 prostanoid receptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(1):35-46.
2001: Najam A Sharif; Julie Y Crider; Shouxi X Xu; M McLaughlin; Terry L Davis
Levobetaxolol (Betaxon): in vitro pharmacology, intraocular pressure lowering activity and autoradiographic localization of beta-adrenoceptors in human eyes.
Proceedings of the Western Pharmacology Society 2001;44():65-8.
2000: Najam A Sharif; Julie Y Crider; Terry L Davis
AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists.
The Journal of pharmacy and pharmacology 2000;52(12):1529-39.
2000: Najam A Sharif; Gary W Williams; Terry L Davis
Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand.
British journal of pharmacology 2000;131(6):1025-38.
2000: Peter G Klimko; Terry L Davis; BW Griffin; Najam A Sharif
Synthesis and biological activity of a novel 11a-homo (cyclohexyl) prostaglandin.
Journal of medicinal chemistry 2000;43(18):3400-7.
2000: Terry L Davis; Najam A Sharif
Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor.
British journal of pharmacology 2000;130(8):1919-26.
2000: Sunny E Ohia; Catherine A Opere; Sunday O Awe; L Adams; Najam A Sharif
Human, bovine, and rabbit retinal glutamate-induced [3H]D-aspartate release: role in excitotoxicity.
Neurochemical research 2000;25(6):853-60.
2000: Najam A Sharif; Julie Y Crider; Shouxi X Xu; Gary W Williams
Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids.
The Journal of pharmacology and experimental therapeutics 2000;293(2):321-8.
2000: Julie Y Crider; BW Griffin; Najam A Sharif
Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization.
Prostaglandins, leukotrienes, and essential fatty acids 2000;62(1):21-6.
1999: BW Griffin; Peter G Klimko; Julie Y Crider; Najam A Sharif
AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1278-84.
1999: Terry L Davis; Najam A Sharif
Quantitative autoradiographic visualization and pharmacology of FP-prostaglandin receptors in human eyes using the novel phosphor-imaging technology.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1999;15(4):323-36.
1999: Najam A Sharif; Terry L Davis; Gary W Williams
[3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor.
The Journal of pharmacy and pharmacology 1999;51(6):685-94.
1999: Najam A Sharif; Shouxi X Xu
Pharmacological characterization of [3H]-Ifenprodil binding to polyamine binding sites on rabbit and rat retinal homogenates: role in neuroprotection?
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1999;15(3):271-81.
1999: Julie Y Crider; BW Griffin; Najam A Sharif
Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists.
British journal of pharmacology 1999;127(1):204-10.
1999: John M Yanni; Lori K Weimer; Najam A Sharif; S X Xu; Daniel A Gamache; Joan M Spellman
Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs.
Archives of ophthalmology 1999;117(5):643-7.
1999: Elizabeth A Offord; Najam A Sharif; Katherine Macé; Y Tromvoukis; E A Spillare; Ornella Avanti; WE Howe; Andrea M A Pfeifer
Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.
Investigative ophthalmology & visual science 1999;40(6):1091-101.
1999: Najam A Sharif; Shouxi X Xu
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection?
The British journal of ophthalmology 1999;83(2):236-40.
1999: John M Yanni; Najam A Sharif; Daniel A Gamache; Steven T Miller; Lori K Weimer; Joan M Spellman
A current appreciation of sites for pharmacological intervention in allergic conjunctivitis: effects of new topical ocular drugs.
Acta ophthalmologica Scandinavica. Supplement 1999;(228):33-7.
1998: Najam A Sharif; TK Wiernas; WE Howe; BW Griffin; Elizabeth A Offord; Andrea M A Pfeifer
Human corneal epithelial cell functional responses to inflammatory agents and their antagonists.
Investigative ophthalmology & visual science 1998;39(13):2562-71.
1998: Najam A Sharif; TK Wiernas; BW Griffin; Terry L Davis
Pharmacology of [3H]-pyrilamine binding and of the histamine-induced inositol phosphates generation, intracellular Ca2+ -mobilization and cytokine release from human corneal epithelial cells.
British journal of pharmacology 1998;125(6):1336-44.
1998: Julie Y Crider; BW Griffin; Najam A Sharif
Prostaglandin-stimulated adenylyl cyclase activity via a pharmacologically defined EP2 receptor in human nonpigmented ciliary epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1998;14(4):293-304.
1998: Najam A Sharif; Shouxi X Xu; Gary W Williams; Julie Y Crider; BW Griffin; Terry L Davis
Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1094-102.
1998: Julie Y Crider; BW Griffin; Shouxi X Xu; Najam A Sharif
Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types.
Prostaglandins, leukotrienes, and essential fatty acids 1998;59(1):77-82.
1998: BW Griffin; PE Magnino; Iok-Hou Pang; Najam A Sharif
Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization.
The Journal of pharmacology and experimental therapeutics 1998;286(1):411-8.
1998: TK Wiernas; Terry L Davis; BW Griffin; Najam A Sharif
Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells.
British journal of pharmacology 1998;123(6):1127-37.
1997: John M Yanni; Steven T Miller; Daniel A Gamache; Joan M Spellman; S Xu; Najam A Sharif
Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1997;79(6):541-5.
1997: David BenEzra; BW Griffin; G Maftzir; Najam A Sharif; A F Clark
Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization.
Investigative ophthalmology & visual science 1997;38(10):1954-62.
1997: Julie Y Crider; Thomas Yorio; Najam A Sharif; BW Griffin
The effects of elevated glucose on Na+/K(+)-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1997;13(4):337-52.
1997: Najam A Sharif; Julie Y Crider; BW Griffin; Terry L Davis; WE Howe
Pharmacological analysis of mast cell mediator and neurotransmitter receptors coupled to adenylate cyclase and phospholipase C on immunocytochemically-defined human conjunctival epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1997;13(4):321-36.
1997: TK Wiernas; BW Griffin; Najam A Sharif
The expression of functionally-coupled B2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists.
British journal of pharmacology 1997;121(4):649-56.
1997: BW Griffin; Gary W Williams; Julie Y Crider; Najam A Sharif
FP prostaglandin receptors mediating inositol phosphates generation and calcium mobilization in Swiss 3T3 cells: a pharmacological study.
The Journal of pharmacology and experimental therapeutics 1997;281(2):845-54.
1997: Julie Y Crider; Gary W Williams; Thomas Yorio; Najam A Sharif; BW Griffin
A new chromatographic method for measurement of rubidium transport activities in cultured bovine retinal pigment epithelial cells.
Ophthalmic research 1997;29(3):117-23.
1996: Najam A Sharif; Shouxi X Xu
Pharmacological characterization of bradykinin receptors coupled to phosphoinositide turnover in SV40-immortalized human trabecular meshwork cells.
Experimental eye research 1996;63(6):631-7.
1996: Najam A Sharif; Shouxi X Xu; Steven T Miller; Daniel A Gamache; John M Yanni
Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1252-61.
1996: Najam A Sharif; Shouxi X Xu; P E Magnino; Iok-Hou Pang
Human conjunctival epithelial cells express histamine-1 receptors coupled to phosphoinositide turnover and intracellular calcium mobilization: role in ocular allergic and inflammatory diseases.
Experimental eye research 1996;63(2):169-78.
1996: Najam A Sharif; Shouxi X Xu; John M Yanni
Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1996;12(4):401-7.
1994: Najam A Sharif; S X Su; John M Yanni
Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies.
Journal of ocular pharmacology 1994;10(4):653-64.