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Manohar Sharma

Research Profile

Chemicals & Drugs

Anatomy

Neuromuscular Junction

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Publications

TOP 3
Peter M C Wright; Gerald McCarthy; Janos Szenohradszky; Manohar L Sharma; James E Caldwell
Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium.
Tom Heier; David Clough; Peter M C Wright; Manohar L Sharma; Daniel Sessler; James E Caldwell
The influence of mild hypothermia on the pharmacokinetics and time course of action of neostigmine in anesthetized volunteers.
Janos Szenohradszky; D Fogarty; H Kirkegaard-Nielsen; Ronald Brown; Manohar L Sharma; Dennis M Fisher
Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.

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All Publications

2004: Peter M C Wright; Gerald McCarthy; Janos Szenohradszky; Manohar L Sharma; James E Caldwell
Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium.
Anesthesiology 2004;100(3):626-33.
2002: Tom Heier; David Clough; Peter M C Wright; Manohar L Sharma; Daniel Sessler; James E Caldwell
The influence of mild hypothermia on the pharmacokinetics and time course of action of neostigmine in anesthetized volunteers.
Anesthesiology 2002;97(1):90-5.
2000: Janos Szenohradszky; D Fogarty; H Kirkegaard-Nielsen; Ronald Brown; Manohar L Sharma; Dennis M Fisher
Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Anesthesiology 2000;92(3):708-14.
2000: James E Caldwell; Tom Heier; Peter M C Wright; S Lin; G McCarthy; Janos Szenohradszky; Manohar L Sharma; Jeremy P Hing; M Schroeder; Daniel Sessler
Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium.
Anesthesiology 2000;92(1):84-93.
1998: V Segredo; James E Caldwell; Peter M C Wright; Manohar L Sharma; L D Gruenke; Ronald D Miller
Do the pharmacokinetics of vecuronium change during prolonged administration in critically ill patients?
British journal of anaesthesia 1998;80(6):715-9.
1998: D A Markakis; M Lau; Ronald Brown; AM Luks; Manohar L Sharma; Dennis M Fisher
The pharmacokinetics and steady state pharmacodynamics of mivacurium in children.
Anesthesiology 1998;88(4):978-83.
1995: Janos Szenohradszky; M Lau; Ronald Brown; Manohar L Sharma; Dennis M Fisher
The effect of neostigmine on twitch tension and muscle relaxant concentration during infusion of mivacurium or vecuronium.
Anesthesiology 1995;83(1):83-7.
1995: P S Hart; Peter M C Wright; Ronald Brown; M Lau; Manohar L Sharma; Ronald D Miller; L Gruenke; Dennis M Fisher
Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis.
Anesthesiology 1995;82(4):912-8.
1995: Peter M C Wright; P Hart; M Lau; Ronald Brown; Manohar L Sharma; L Gruenke; Dennis M Fisher
The magnitude and time course of vecuronium potentiation by desflurane versus isoflurane.
Anesthesiology 1995;82(2):404-11.
1995: S D Kelley; C B Cauldwell; Dennis M Fisher; M Lau; Manohar L Sharma; R A Weisiger
Recovery of hepatic drug extraction after hypothermic preservation.
Anesthesiology 1995;82(1):251-8.
1994: James E Caldwell; Janos Szenohradszky; V Segredo; Peter M C Wright; C McLoughlin; Manohar L Sharma; L D Gruenke; Dennis M Fisher; Ronald D Miller
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1216-22.
1994: Peter M C Wright; P Hart; M Lau; Manohar L Sharma; L Gruenke; Dennis M Fisher
Cumulative characteristics of atracurium and vecuronium. A simultaneous clinical and pharmacokinetic study.
Anesthesiology 1994;81(1):59-68; discussion 27A.
1994: Janos Szenohradszky; James E Caldwell; Manohar L Sharma; L D Gruenke; Ronald D Miller
Interaction of rocuronium (ORG 9426) and phenytoin in a patient undergoing cadaver renal transplantation: a possible pharmacokinetic mechanism?
Anesthesiology 1994;80(5):1167-70.
1994: T Heier; James E Caldwell; Manohar L Sharma; L D Gruenke; Ronald D Miller
Mild intraoperative hypothermia does not change the pharmacodynamics (concentration-effect relationship) of vecuronium in humans.
Anesthesia and analgesia 1994;78(5):973-7.
1993: Janos Szenohradszky; A J Trevor; Philip E Bickler; James E Caldwell; Manohar L Sharma; Ira J Rampil; Ronald D Miller
Central nervous system effects of intrathecal muscle relaxants in rats.
Anesthesia and analgesia 1993;76(6):1304-9.
1992: Janos Szenohradszky; Dennis M Fisher; V Segredo; James E Caldwell; P Bragg; Manohar L Sharma; L D Gruenke; Ronald D Miller
Pharmacokinetics of rocuronium bromide (ORG 9426) in patients with normal renal function or patients undergoing cadaver renal transplantation.
Anesthesiology 1992;77(5):899-904.
1992: V Segredo; James E Caldwell; M A Matthay; Manohar L Sharma; L D Gruenke; Ronald D Miller
Persistent paralysis in critically ill patients after long-term administration of vecuronium.
The New England journal of medicine 1992;327(8):524-8.
1991: V Segredo; Y S Shin; Manohar L Sharma; L D Gruenke; James E Caldwell; K S Khuenl-Brady; S Agoston; Ronald D Miller
Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats.
Anesthesiology 1991;74(6):1052-9.
1990: V Segredo; M A Matthay; Manohar L Sharma; L D Gruenke; James E Caldwell; Ronald D Miller
Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients.
Anesthesiology 1990;72(3):566-70.
1988: T Furuta; P C Canfell; K P Castagnoli; Manohar L Sharma; Ronald D Miller
Quantitation of pancuronium, 3-desacetylpancuronium, vecuronium, 3-desacetylvecuronium, pipecuronium and 3-desacetylpipecuronium in biological fluids by capillary gas chromatography using nitrogen-sensitive detection.
Journal of chromatography 1988;427(1):41-53.