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Alan Sharp

Research Profile

Chemicals & Drugs

Disorders

Huntington's Disease

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Anatomy

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Publications

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Daniel Goti; Scott M Katzen; Jesse Mez; Noam Kurtis; Jennifer Kiluk; Lea Ben-Haïem; Nancy A Jenkins; Neal G Copeland; Akira Kakizuka; Alan H Sharp; Christopher A Ross; Peter R Mouton; Veronica F Colomer Gould
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Seth Blackshaw; Akira Sawa; Alan H Sharp; Christopher A Ross; Solomon H Snyder; A A Khan
Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death.
Susan E Holmes; Elizabeth O'Hearn; Melvin G McInnis; D A Gorelick-Feldman; John Kleiderlein; Colleen Callahan; N G Kwak; R G Ingersoll-Ashworth; M Sherr; A J Sumner; Alan H Sharp; U Ananth; William K Seltzer; MA Boss; A M Vieria-Saecker; J T Epplen; Olaf Riess; Christopher A Ross; Russell L Margolis
Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12.

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All Publications

2004: Daniel Goti; Scott M Katzen; Jesse Mez; Noam Kurtis; Jennifer Kiluk; Lea Ben-Haïem; Nancy A Jenkins; Neal G Copeland; Akira Kakizuka; Alan H Sharp; Christopher A Ross; Peter R Mouton; Veronica F Colomer Gould
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(45):10266-79.
2000: Seth Blackshaw; Akira Sawa; Alan H Sharp; Christopher A Ross; Solomon H Snyder; A A Khan
Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1375-9.
1999: Susan E Holmes; Elizabeth O'Hearn; Melvin G McInnis; D A Gorelick-Feldman; John Kleiderlein; Colleen Callahan; N G Kwak; R G Ingersoll-Ashworth; M Sherr; A J Sumner; Alan H Sharp; U Ananth; William K Seltzer; MA Boss; A M Vieria-Saecker; J T Epplen; Olaf Riess; Christopher A Ross; Russell L Margolis
Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12.
Nature genetics 1999;23(4):391-2.
1999: Akira Sawa; GW Wiegand; J Cooper; Russell L Margolis; Alan H Sharp; Joseph F Lawler; J Timothy Greenamyre; Solomon H Snyder; Christopher A Ross
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization.
Nature medicine 1999;5(10):1194-8.
1999: Christopher A Ross; Jonathan D Wood; Gabriele Schilling; Matthew F Peters; Frederick C Nucifora; Jillian K Cooper; Alan H Sharp; Russell L Margolis; David R Borchelt
Polyglutamine pathogenesis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1005-11.
1999: Simone Engelender; Z Kaminsky; X Guo; Alan H Sharp; R K Amaravi; John Kleiderlein; Russell L Margolis; Juan C Troncoso; Anthony A Lanahan; Paul F Worley; Valina Dawson; Ted M Dawson; Christopher A Ross
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.
Nature genetics 1999;22(1):110-4.
1999: Alan H Sharp; Frederick C Nucifora; O Blondel; CA Sheppard; C Zhang; Solomon H Snyder; James T Russell; David Ryugo; Christopher A Ross
Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain.
The Journal of comparative neurology 1999;406(2):207-20.
1999: Gabriele Schilling; Mark W Becher; Alan H Sharp; Hyder A Jinnah; K Duan; JA Kotzuk; Hilda H Slunt; TAMARA RATOVITSKI; Jillian K Cooper; Nancy A Jenkins; Neal G Copeland; Donald L Price; Christopher A Ross; David R Borchelt
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
Human molecular genetics 1999;8(3):397-407.
1998: Jonathan D Wood; J Yuan; Russell L Margolis; Veronica F Colomer Gould; K Duan; J Kushi; Z Kaminsky; John Kleiderlein; Alan H Sharp; Christopher A Ross
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
Molecular and cellular neurosciences 1998;11(3):149-60.
1998: Jillian K Cooper; Gabriele Schilling; Matthew F Peters; William Joseph Herring; Alan H Sharp; Z Kaminsky; J Masone; F A Khan; M Delanoy; David R Borchelt; Valina Dawson; Ted M Dawson; Christopher A Ross
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.
Human molecular genetics 1998;7(5):783-90.
1998: Mark W Becher; JA Kotzuk; Alan H Sharp; SW Davies; Gillian P Bates; Donald L Price; Christopher A Ross
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length.
Neurobiology of disease 1998;4(6):387-97.
1998: Christopher A Ross; Russell L Margolis; Mark W Becher; Jonathan D Wood; Simone Engelender; Jillian K Cooper; Alan H Sharp
Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions.
Progress in brain research 1998;117():397-419.
1997: Simone Engelender; Alan H Sharp; Veronica F Colomer Gould; Mariko Tokito; Anthony A Lanahan; Paul F Worley; Erika L F Holzbaur; Christopher A Ross
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Human molecular genetics 1997;6(13):2205-12.
1997: Veronica F Colomer Gould; Simone Engelender; Alan H Sharp; K Duan; Jillian K Cooper; Anthony A Lanahan; Gregory Lyford; Paul F Worley; Christopher A Ross
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
Human molecular genetics 1997;6(9):1519-25.
1997: SW Davies; Mark Turmaine; B A Cozens; Marian DiFiglia; Alan H Sharp; Christopher A Ross; Eberhard Scherzinger; Erich E Wanker; L Mangiarini; Gillian P Bates
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
Cell 1997;90(3):537-48.
1997: Christopher A Ross; Mark W Becher; Veronica F Colomer Gould; Simone Engelender; Jonathan D Wood; Alan H Sharp
Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology.
Brain pathology (Zurich, Switzerland) 1997;7(3):1003-16.
1997: CA Sheppard; PB Simpson; Alan H Sharp; Frederick C Nucifora; Christopher A Ross; G D Lange; James T Russell
Comparison of type 2 inositol 1,4,5-trisphosphate receptor distribution and subcellular Ca2+ release sites that support Ca2+ waves in cultured astrocytes.
Journal of neurochemistry 1997;68(6):2317-27.
1996: A A Khan; Mark J Soloski; Alan H Sharp; Gabriele Schilling; DM Sabatini; S H Li; Christopher A Ross; Solomon H Snyder
Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor.
Science (New York, N.Y.) 1996;273(5274):503-7.
1996: Frederick C Nucifora; Alan H Sharp; Sharon L Milgram; Christopher A Ross
Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.
Molecular biology of the cell 1996;7(6):949-60.
1996: J Bao; Alan H Sharp; M V Wagster; Mark W Becher; Gabriele Schilling; Christopher A Ross; Valina Dawson; Ted M Dawson
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5037-42.
1996: Xiao-Jiang Li; Alan H Sharp; S H Li; Ted M Dawson; Solomon H Snyder; Christopher A Ross
Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4839-44.
1996: F A Khan; Russell L Margolis; S L Loev; Alan H Sharp; S H Li; Christopher A Ross
cDNA cloning and characterization of an atrophin-1 (DRPLA disease gene)-related protein.
Neurobiology of disease 1996;3(2):121-8.
1996: Alan H Sharp; Christopher A Ross
Neurobiology of Huntington's disease.
Neurobiology of disease 1996;3(1):3-15.
1995: Xiao-Jiang Li; S H Li; Alan H Sharp; Frederick C Nucifora; Gabriele Schilling; Anthony A Lanahan; Paul F Worley; Solomon H Snyder; Christopher A Ross
A huntingtin-associated protein enriched in brain with implications for pathology.
Nature 1995;378(6555):398-402.
1995: Gabriele Schilling; Alan H Sharp; S J Loev; M V Wagster; S H Li; O Colin Stine; Christopher A Ross
Expression of the Huntington's disease (IT15) protein product in HD patients.
Human molecular genetics 1995;4(8):1365-71.
1995: David Ryugo; Tan Pongstaporn; D D Wright; Alan H Sharp
Inositol 1,4,5-trisphosphate receptors: immunocytochemical localization in the dorsal cochlear nucleus.
The Journal of comparative neurology 1995;358(1):102-18.
1995: Alan H Sharp; S J Loev; Gabriele Schilling; S H Li; Xiao-Jiang Li; J Bao; M V Wagster; J A Kotzuk; Joseph P Steiner; A Lo
Widespread expression of Huntington's disease gene (IT15) protein product.
Neuron 1995;14(5):1065-74.
1994: O Blondel; M M Moody; A M Depaoli; Alan H Sharp; Christopher A Ross; Hewson H Swift; Graeme I Bell
Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7777-81.
1993: A M Cunningham; David Ryugo; Alan H Sharp; Randall R Reed; Solomon H Snyder; Gabriele V Ronnett
Neuronal inositol 1,4,5-trisphosphate receptor localized to the plasma membrane of olfactory cilia.
Neuroscience 1993;57(2):339-52.
1993: MAJID FOTUHI; Ted M Dawson; Alan H Sharp; Lee J Martin; Ann M Graybiel; Solomon H Snyder
Phosphoinositide second messenger system is enriched in striosomes: immunohistochemical demonstration of inositol 1,4,5-trisphosphate receptors and phospholipase C beta and gamma in primate basal ganglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(8):3300-8.
1993: Alan H Sharp; P S McPherson; Ted M Dawson; C Aoki; K P Campbell; Solomon H Snyder
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):3051-63.
1993: MAJID FOTUHI; Alan H Sharp; C E Glatt; PAUL HWANG; M von Krosigk; Solomon H Snyder; Ted M Dawson
Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(5):2001-12.
1993: Alan H Sharp; Ted M Dawson; Christopher A Ross; MAJID FOTUHI; R J Mourey; Solomon H Snyder
Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system.
Neuroscience 1993;53(4):927-42.
1992: Alan H Sharp; Solomon H Snyder; S K Nigam
Inositol 1,4,5-trisphosphate receptors. Localization in epithelial tissue.
The Journal of biological chemistry 1992;267(11):7444-9.
1991: Maureen W McEnery; Adele M Snowman; Alan H Sharp; M E Adams; Solomon H Snyder
Purified omega-conotoxin GVIA receptor of rat brain resembles a dihydropyridine-sensitive L-type calcium channel.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11095-9.
1991: Y W Peng; Alan H Sharp; Solomon H Snyder; King-Wai Yau
Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina.
Neuron 1991;6(4):525-31.
1991: S D Jay; Alan H Sharp; Steven D Kahl; Thomas Vedvick; Michael M Harpold; Kevin P Campbell
Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides.
The Journal of biological chemistry 1991;266(5):3287-93.
1989: Alan H Sharp; Kevin P Campbell
Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies. Evidence for a 32,000-Da subunit.
The Journal of biological chemistry 1989;264(5):2816-25.
1989: C M Knudson; Nirupa Chaudhari; Alan H Sharp; J A Powell; Kurt G Beam; Kevin P Campbell
Specific absence of the alpha 1 subunit of the dihydropyridine receptor in mice with muscular dysgenesis.
The Journal of biological chemistry 1989;264(3):1345-8.
1989: Kevin P Campbell; Alan H Sharp; A T Leung
32,000-Dalton subunit of the 1,4-dihydropyridine receptor.
Annals of the New York Academy of Sciences 1989;560():251-7.
1988: Kevin P Campbell; A T Leung; Alan H Sharp
The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel.
Trends in neurosciences 1988;11(10):425-30.
1988: SB Ellis; Mark E Williams; N R Ways; R Brenner; Alan H Sharp; A T Leung; Kevin P Campbell; E McKenna; W J Koch; A Hui
Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.
Science (New York, N.Y.) 1988;241(4873):1661-4.
1987: Alan H Sharp; Kevin P Campbell
Affinity purification of antibodies specific for 1,4-dihydropyridine Ca2+ channel blockers.
Circulation research 1987;61(4 Pt 2):I37-45.
1987: Alan H Sharp; T Imagawa; A T Leung; Kevin P Campbell
Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.
The Journal of biological chemistry 1987;262(25):12309-15.